                         SEQUENCE LISTING

<110>  Defensin Therapeutics ApS
 
<120>  Maturation of mucosal defense and gut/lung function in the 
       preterm infant

<130>  P4704PC00

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210>  2
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Gly Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His 
1               5                   10                  15      


Pro Val Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu 
            20                  25                  30          


Pro Gly Thr Lys Cys Cys Lys Lys Pro 
        35                  40      


<210>  3
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr Cys Arg Val Arg Gly Gly 
1               5                   10                  15      


Arg Cys Ala Val Leu Ser Cys Leu Pro Lys Glu Glu Gln Ile Gly Lys 
            20                  25                  30          


Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg Arg Lys 
        35                  40                  


<210>  4
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Leu Asp Arg Ile Cys Gly Tyr Gly Thr Ala Arg Cys Arg Lys Lys 
1               5                   10                  15      


Cys Arg Ser Gln Glu Tyr Arg Ile Gly Arg Cys Pro Asn Thr Tyr Ala 
            20                  25                  30          


Cys Cys Leu Arg Lys 
        35          


<210>  5
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Thr Cys Tyr Cys Arg Thr Gly Arg Cys Ala Thr Arg Glu Ser Leu 
1               5                   10                  15      


Ser Gly Val Cys Glu Ile Ser Gly Arg Leu Tyr Arg Leu Cys Cys Arg 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Phe Thr Cys His Cys Arg Arg Ser Cys Tyr Ser Thr Glu Tyr Ser 
1               5                   10                  15      


Tyr Gly Thr Cys Thr Val Met Gly Ile Asn His Arg Phe Cys Cys Leu 
            20                  25                  30          


<210>  7
<211>  40
<212>  PRT
<213>  Mus musculus

<400>  7

Lys Ile Asn Asn Pro Val Ser Cys Leu Arg Lys Gly Gly Arg Cys Trp 
1               5                   10                  15      


Asn Arg Cys Ile Gly Asn Thr Arg Gln Ile Gly Ser Cys Gly Val Pro 
            20                  25                  30          


Phe Leu Lys Cys Cys Lys Arg Lys 
        35                  40  


<210>  8
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210>  9
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  9

Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr Gly 
1               5                   10                  15      


Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  


<210>  10
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210>  11
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Cys Ser Cys Arg Leu Val Phe Cys Arg Arg Thr Glu Leu Arg Val 
1               5                   10                  15      


Gly Asn Cys Leu Ile Gly Gly Val Ser Phe Thr Tyr Cys Cys Thr Arg 
            20                  25                  30          


Val 
    


<210>  12
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  13
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu Ala 
1               5                   10                  15      


Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro 
            20                  25                  30          


Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln Ala 
        35                  40                  45              


Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly Gly Phe Ile 
    50                  55                  60                  


Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val Ala Ala Glu 
65                  70                  75                  80  


Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr Ala Val Ala 
                85                  90                  95      


Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly Leu 
            100                 105                 110         


Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp Asn Val Pro 
        115                 120                 125             


Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro Pro Glu Pro 
    130                 135                 140                 


Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys Val Pro Gly 
145                 150                 155                 160 


Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys Ala Gly Thr 
                165                 170                 175     


Gly Glu Asn Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser Tyr Ser 
            180                 185                 190         


Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp Val Ala Phe Ile 
        195                 200                 205             


Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu Ala Glu Arg Asp 
    210                 215                 220                 


Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys Pro Val Asp Lys 
225                 230                 235                 240 


Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His Ala Val Val Ala 
                245                 250                 255     


Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn Leu Leu Arg Gln 
            260                 265                 270         


Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys Phe Gln Leu Phe 
        275                 280                 285             


Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys Asp Ser Ala Ile 
    290                 295                 300                 


Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly Leu Tyr Leu Gly 
305                 310                 315                 320 


Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys Ser Glu Glu Glu 
                325                 330                 335     


Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala Val Gly Glu Gln 
            340                 345                 350         


Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser Glu Gly Ser Val 
        355                 360                 365             


Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile Ala Leu Val Leu 
    370                 375                 380                 


Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val Tyr Thr 
385                 390                 395                 400 


Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Lys Ser 
                405                 410                 415     


Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro Val Glu 
            420                 425                 430         


Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser Leu Thr 
        435                 440                 445             


Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val Asp Arg 
    450                 455                 460                 


Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln Thr Gly 
465                 470                 475                 480 


Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro Gly Ser 
                485                 490                 495     


Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu Gln Gly 
            500                 505                 510         


Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly Tyr Thr 
        515                 520                 525             


Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala Phe Val 
    530                 535                 540                 


Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn Glu Ala 
545                 550                 555                 560 


Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys Leu Asp 
                565                 570                 575     


Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu Ala Met 
            580                 585                 590         


Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu Arg Leu 
        595                 600                 605             


Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn Gly Ser 
    610                 615                 620                 


Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys Asn Leu 
625                 630                 635                 640 


Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly Lys Thr 
                645                 650                 655     


Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile Thr Asn 
            660                 665                 670         


Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu Phe Leu 
        675                 680                 685             


Arg Lys 
    690 


<210>  14
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln Pro Glu Ala 
1               5                   10                  15      


Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro 
            20                  25                  30          


Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys Ile Gln Ala 
        35                  40                  45              


<210>  15
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg Leu Gly 
1               5                   10                  15      


Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys Leu Ala 
            20                  25                  30          


Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn Ala Gly 
        35                  40                  45              


Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg Tyr Trp 
    50                  55                  60                  


Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His Leu Ser 
65                  70                  75                  80  


Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala Cys Ala 
                85                  90                  95      


Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val Ala Trp 
            100                 105                 110         


Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln Gly Cys 
        115                 120                 125             


Gly Val 
    130 


<210>  16
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  16

Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro Val Phe Cys 
1               5                   10                  15      


Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro Gly Thr Lys 
            20                  25                  30          


Cys Cys Lys Lys Pro 
        35          


