                         SEQUENCE LISTING

<110>  Snap Bio, Inc.
 
<120>  PIM kinase inhibitor compositions, methods, and uses thereof

<130>  SNA0003WO

<140>  62/581917
<141>  2018-10-31

<150>  62/581917
<151>  2017-11-06

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  418
<212>  PRT
<213>  Chromobacterium violaceum

<400>  1

Met Lys His Ser Ser Asp Ile Cys Ile Val Gly Ala Gly Ile Ser Gly 
1               5                   10                  15      


Leu Thr Cys Ala Ser His Leu Leu Asp Ser Pro Ala Cys Arg Gly Leu 
            20                  25                  30          


Ser Leu Arg Ile Phe Asp Met Gln Gln Glu Ala Gly Gly Arg Ile Arg 
        35                  40                  45              


Ser Lys Met Leu Asp Gly Lys Ala Ser Ile Glu Leu Gly Ala Gly Arg 
    50                  55                  60                  


Tyr Ser Pro Gln Leu His Pro His Phe Gln Ser Ala Met Gln His Tyr 
65                  70                  75                  80  


Ser Gln Lys Ser Glu Val Tyr Pro Phe Thr Gln Leu Lys Phe Lys Ser 
                85                  90                  95      


His Val Gln Gln Lys Leu Lys Arg Ala Met Asn Glu Leu Ser Pro Arg 
            100                 105                 110         


Leu Lys Glu His Gly Lys Glu Ser Phe Leu Gln Phe Val Ser Arg Tyr 
        115                 120                 125             


Gln Gly His Asp Ser Ala Val Gly Met Ile Arg Ser Met Gly Tyr Asp 
    130                 135                 140                 


Ala Leu Phe Leu Pro Asp Ile Ser Ala Glu Met Ala Tyr Asp Ile Val 
145                 150                 155                 160 


Gly Lys His Pro Glu Ile Gln Ser Val Thr Asp Asn Asp Ala Asn Gln 
                165                 170                 175     


Trp Phe Ala Ala Glu Thr Gly Phe Ala Gly Leu Ile Gln Gly Ile Lys 
            180                 185                 190         


Ala Lys Val Lys Ala Ala Gly Ala Arg Phe Ser Leu Gly Tyr Arg Leu 
        195                 200                 205             


Leu Ser Val Arg Thr Asp Gly Asp Gly Tyr Leu Leu Gln Leu Ala Gly 
    210                 215                 220                 


Asp Asp Gly Trp Lys Leu Glu His Arg Thr Arg His Leu Ile Leu Ala 
225                 230                 235                 240 


Ile Pro Pro Ser Ala Met Ala Gly Leu Asn Val Asp Phe Pro Glu Ala 
                245                 250                 255     


Trp Ser Gly Ala Arg Tyr Gly Ser Leu Pro Leu Phe Lys Gly Phe Leu 
            260                 265                 270         


Thr Tyr Gly Glu Pro Trp Trp Leu Asp Tyr Lys Leu Asp Asp Gln Val 
        275                 280                 285             


Leu Ile Val Asp Asn Pro Leu Arg Lys Ile Tyr Phe Lys Gly Asp Lys 
    290                 295                 300                 


Tyr Leu Phe Phe Tyr Thr Asp Ser Glu Met Ala Asn Tyr Trp Arg Gly 
305                 310                 315                 320 


Cys Val Ala Glu Gly Glu Asp Gly Tyr Leu Glu Gln Ile Arg Thr His 
                325                 330                 335     


Leu Ala Ser Ala Leu Gly Ile Val Arg Glu Arg Ile Pro Gln Pro Leu 
            340                 345                 350         


Ala His Val His Lys Tyr Trp Ala His Gly Val Glu Phe Cys Arg Asp 
        355                 360                 365             


Ser Asp Ile Asp His Pro Ser Ala Leu Ser His Arg Asp Ser Gly Ile 
    370                 375                 380                 


Ile Ala Cys Ser Asp Ala Tyr Thr Glu His Cys Gly Trp Met Glu Gly 
385                 390                 395                 400 


Gly Leu Leu Ser Ala Arg Glu Ala Ser Arg Leu Leu Leu Gln Arg Ile 
                405                 410                 415     


Ala Ala 
        


<210>  2
<211>  998
<212>  PRT
<213>  Chromobacterium violaceum

<400>  2

Met Ser Ile Leu Asp Phe Pro Arg Ile His Phe Arg Gly Trp Ala Arg 
1               5                   10                  15      


Val Asn Ala Pro Thr Ala Asn Arg Asp Pro His Gly His Ile Asp Met 
            20                  25                  30          


Ala Ser Asn Thr Val Ala Met Ala Gly Glu Pro Phe Asp Leu Ala Arg 
        35                  40                  45              


His Pro Thr Glu Phe His Arg His Leu Arg Ser Leu Gly Pro Arg Phe 
    50                  55                  60                  


Gly Leu Asp Gly Arg Ala Asp Pro Glu Gly Pro Phe Ser Leu Ala Glu 
65                  70                  75                  80  


Gly Tyr Asn Ala Ala Gly Asn Asn His Phe Ser Trp Glu Ser Ala Thr 
                85                  90                  95      


Val Ser His Val Gln Trp Asp Gly Gly Glu Ala Asp Arg Gly Asp Gly 
            100                 105                 110         


Leu Val Gly Ala Arg Leu Ala Leu Trp Gly His Tyr Asn Asp Tyr Leu 
        115                 120                 125             


Arg Thr Thr Phe Asn Arg Ala Arg Trp Val Asp Ser Asp Pro Thr Arg 
    130                 135                 140                 


Arg Asp Ala Ala Gln Ile Tyr Ala Gly Gln Phe Thr Ile Ser Pro Ala 
145                 150                 155                 160 


Gly Ala Gly Pro Gly Thr Pro Trp Leu Phe Thr Ala Asp Ile Asp Asp 
                165                 170                 175     


Ser His Gly Ala Arg Trp Thr Arg Gly Gly His Ile Ala Glu Arg Gly 
            180                 185                 190         


Gly His Phe Leu Asp Glu Glu Phe Gly Leu Ala Arg Leu Phe Gln Phe 
        195                 200                 205             


Ser Val Pro Lys Asp His Pro His Phe Leu Phe His Pro Gly Pro Phe 
    210                 215                 220                 


Asp Ser Glu Ala Trp Arg Arg Leu Gln Leu Ala Leu Glu Asp Asp Asp 
225                 230                 235                 240 


Val Leu Gly Leu Thr Val Gln Tyr Ala Leu Phe Asn Met Ser Thr Pro 
                245                 250                 255     


Pro Gln Pro Asn Ser Pro Val Phe His Asp Met Val Gly Val Val Gly 
            260                 265                 270         


Leu Trp Arg Arg Gly Glu Leu Ala Ser Tyr Pro Ala Gly Arg Leu Leu 
        275                 280                 285             


Arg Pro Arg Gln Pro Gly Leu Gly Asp Leu Thr Leu Arg Val Ser Gly 
    290                 295                 300                 


Gly Arg Val Ala Leu Asn Leu Ala Cys Ala Ile Pro Phe Ser Thr Arg 
305                 310                 315                 320 


Ala Ala Gln Pro Ser Ala Pro Asp Arg Leu Thr Pro Asp Leu Gly Ala 
                325                 330                 335     


Lys Leu Pro Leu Gly Asp Leu Leu Leu Arg Asp Glu Asp Gly Ala Leu 
            340                 345                 350         


Leu Ala Arg Val Pro Gln Ala Leu Tyr Gln Asp Tyr Trp Thr Asn His 
        355                 360                 365             


Gly Ile Val Asp Leu Pro Leu Leu Arg Glu Pro Arg Gly Ser Leu Thr 
    370                 375                 380                 


Leu Ser Ser Glu Leu Ala Glu Trp Arg Glu Gln Asp Trp Val Thr Gln 
385                 390                 395                 400 


Ser Asp Ala Ser Asn Leu Tyr Leu Glu Ala Pro Asp Arg Arg His Gly 
                405                 410                 415     


Arg Phe Phe Pro Glu Ser Ile Ala Leu Arg Ser Tyr Phe Arg Gly Glu 
            420                 425                 430         


Ala Arg Ala Arg Pro Asp Ile Pro His Arg Ile Glu Gly Met Gly Leu 
        435                 440                 445             


Val Gly Val Glu Ser Arg Gln Asp Gly Asp Ala Ala Glu Trp Arg Leu 
    450                 455                 460                 


Thr Gly Leu Arg Pro Gly Pro Ala Arg Ile Val Leu Asp Asp Gly Ala 
465                 470                 475                 480 


Glu Ala Ile Pro Leu Arg Val Leu Pro Asp Asp Trp Ala Leu Asp Asp 
                485                 490                 495     


Ala Thr Val Glu Glu Val Asp Tyr Ala Phe Leu Tyr Arg His Val Met 
            500                 505                 510         


Ala Tyr Tyr Glu Leu Val Tyr Pro Phe Met Ser Asp Lys Val Phe Ser 
        515                 520                 525             


Leu Ala Asp Arg Cys Lys Cys Glu Thr Tyr Ala Arg Leu Met Trp Gln 
    530                 535                 540                 


Met Cys Asp Pro Gln Asn Arg Asn Lys Ser Tyr Tyr Met Pro Ser Thr 
545                 550                 555                 560 


Arg Glu Leu Ser Ala Pro Lys Ala Arg Leu Phe Leu Lys Tyr Leu Ala 
                565                 570                 575     


His Val Glu Gly Gln Ala Arg Leu Gln Ala Pro Pro Pro Ala Gly Pro 
            580                 585                 590         


Ala Arg Ile Glu Ser Lys Ala Gln Leu Ala Ala Glu Leu Arg Lys Ala 
        595                 600                 605             


Val Asp Leu Glu Leu Ser Val Met Leu Gln Tyr Leu Tyr Ala Ala Tyr 
    610                 615                 620                 


Ser Ile Pro Asn Tyr Ala Gln Gly Gln Gln Arg Val Arg Asp Gly Ala 
625                 630                 635                 640 


Trp Thr Ala Glu Gln Leu Gln Leu Ala Cys Gly Ser Gly Asp Arg Arg 
                645                 650                 655     


Arg Asp Gly Gly Ile Arg Ala Ala Leu Leu Glu Ile Ala His Glu Glu 
            660                 665                 670         


Met Ile His Tyr Leu Val Val Asn Asn Leu Leu Met Ala Leu Gly Glu 
        675                 680                 685             


Pro Phe Tyr Ala Gly Val Pro Leu Met Gly Glu Ala Ala Arg Gln Ala 
    690                 695                 700                 


Phe Gly Leu Asp Thr Glu Phe Ala Leu Glu Pro Phe Ser Glu Ser Thr 
705                 710                 715                 720 


Leu Ala Arg Phe Val Arg Leu Glu Trp Pro His Phe Ile Pro Ala Pro 
                725                 730                 735     


Gly Lys Ser Ile Ala Asp Cys Tyr Ala Ala Ile Arg Gln Ala Phe Leu 
            740                 745                 750         


Asp Leu Pro Asp Leu Phe Gly Gly Glu Ala Gly Lys Arg Gly Gly Glu 
        755                 760                 765             


His His Leu Phe Leu Asn Glu Leu Thr Asn Arg Ala His Pro Gly Tyr 
    770                 775                 780                 


Gln Leu Glu Val Phe Asp Arg Asp Ser Ala Leu Phe Gly Ile Ala Phe 
785                 790                 795                 800 


Val Thr Asp Gln Gly Glu Gly Gly Ala Leu Asp Ser Pro His Tyr Glu 
                805                 810                 815     


His Ser His Phe Gln Arg Leu Arg Glu Met Ser Ala Arg Ile Met Ala 
            820                 825                 830         


Gln Ser Ala Pro Phe Glu Pro Ala Leu Pro Ala Leu Arg Asn Pro Val 
        835                 840                 845             


Leu Asp Glu Ser Pro Gly Cys Gln Arg Val Ala Asp Gly Arg Ala Arg 
    850                 855                 860                 


Ala Leu Met Ala Leu Tyr Gln Gly Val Tyr Glu Leu Met Phe Ala Met 
865                 870                 875                 880 


Met Ala Gln His Phe Ala Val Lys Pro Leu Gly Ser Leu Arg Arg Ser 
                885                 890                 895     


Arg Leu Met Asn Ala Ala Ile Asp Leu Met Thr Gly Leu Leu Arg Pro 
            900                 905                 910         


Leu Ser Cys Ala Leu Met Asn Leu Pro Ser Gly Ile Ala Gly Arg Thr 
        915                 920                 925             


Ala Gly Pro Pro Leu Pro Gly Pro Val Asp Thr Arg Ser Tyr Asp Asp 
    930                 935                 940                 


Tyr Ala Leu Gly Cys Arg Met Leu Ala Arg Arg Cys Glu Arg Leu Leu 
945                 950                 955                 960 


Glu Gln Ala Ser Met Leu Glu Pro Gly Trp Leu Pro Asp Ala Gln Met 
                965                 970                 975     


Glu Leu Leu Asp Phe Tyr Arg Arg Gln Met Leu Asp Leu Ala Cys Gly 
            980                 985                 990         


Lys Leu Ser Arg Glu Ala 
        995             


<210>  3
<211>  529
<212>  PRT
<213>  Lechevalieria aerocolonigenes

<400>  3

Met Asn Ala Pro Ile Glu Thr Asp Val Leu Ile Leu Gly Gly Gly Pro 
1               5                   10                  15      


Val Gly Met Ala Leu Ala Leu Asp Leu Ala His Arg Gln Val Gly His 
            20                  25                  30          


Leu Val Val Glu Gln Thr Asp Gly Thr Ile Thr His Pro Arg Val Gly 
        35                  40                  45              


Thr Ile Gly Pro Arg Ser Met Glu Leu Phe Arg Arg Trp Gly Val Ala 
    50                  55                  60                  


Lys Gln Ile Arg Thr Ala Gly Trp Pro Gly Asp His Pro Leu Asp Ala 
65                  70                  75                  80  


Ala Trp Val Thr Arg Val Gly Gly His Glu Val Tyr Arg Ile Pro Leu 
                85                  90                  95      


Gly Thr Ala Asp Thr Arg Ala Thr Pro Glu His Thr Pro Glu Pro Asp 
            100                 105                 110         


Ala Ile Cys Pro Gln His Trp Leu Ala Pro Leu Leu Ala Glu Ala Val 
        115                 120                 125             


Gly Glu Arg Leu Arg Thr Arg Ser Arg Leu Asp Ser Phe Glu Gln Arg 
    130                 135                 140                 


Asp Asp His Val Arg Ala Thr Ile Thr Asp Leu Arg Thr Gly Ala Thr 
145                 150                 155                 160 


Arg Ala Val His Ala Arg Tyr Leu Val Ala Cys Asp Gly Ala Ser Ser 
                165                 170                 175     


Pro Thr Arg Lys Ala Leu Gly Ile Asp Ala Pro Pro Arg His Arg Thr 
            180                 185                 190         


Gln Val Phe Arg Asn Ile Leu Phe Arg Ala Pro Glu Leu Arg Ser Leu 
        195                 200                 205             


Leu Gly Glu Arg Ala Ala Leu Phe Phe Phe Leu Met Leu Ser Ser Ser 
    210                 215                 220                 


Leu Arg Phe Pro Leu Arg Ala Leu Asp Gly Arg Gly Leu Tyr Arg Leu 
225                 230                 235                 240 


Thr Val Gly Val Asp Asp Ala Ser Lys Ser Thr Met Asp Ser Phe Glu 
                245                 250                 255     


Leu Val Arg Arg Ala Val Ala Phe Asp Thr Glu Ile Glu Val Leu Ser 
            260                 265                 270         


Asp Ser Glu Trp His Leu Thr His Arg Val Ala Asp Ser Phe Ser Ala 
        275                 280                 285             


Gly Arg Val Phe Leu Thr Gly Asp Ala Ala His Thr Leu Ser Pro Ser 
    290                 295                 300                 


Gly Gly Phe Gly Met Asn Thr Gly Ile Gly Ser Ala Ala Asp Leu Gly 
305                 310                 315                 320 


Trp Lys Leu Ala Ala Thr Leu Arg Gly Trp Ala Gly Pro Gly Leu Leu 
                325                 330                 335     


Ala Thr Tyr Glu Glu Glu Arg Arg Pro Val Ala Ile Thr Ser Leu Glu 
            340                 345                 350         


Glu Ala Asn Val Asn Leu Arg Arg Thr Met Asp Arg Glu Leu Pro Pro 
        355                 360                 365             


Gly Leu His Asp Asp Gly Pro Arg Gly Glu Arg Ile Arg Ala Ala Val 
    370                 375                 380                 


Ala Glu Lys Leu Glu Arg Ser Gly Ala Arg Arg Glu Phe Asp Ala Pro 
385                 390                 395                 400 


Gly Ile His Phe Gly His Thr Tyr Arg Ser Ser Ile Val Cys Gly Glu 
                405                 410                 415     


Pro Glu Thr Glu Val Ala Thr Gly Gly Trp Arg Pro Ser Ala Arg Pro 
            420                 425                 430         


Gly Ala Arg Ala Pro His Ala Trp Leu Thr Pro Thr Thr Ser Thr Leu 
        435                 440                 445             


Asp Leu Phe Gly Arg Gly Phe Val Leu Leu Ser Phe Gly Thr Thr Asp 
    450                 455                 460                 


Gly Val Glu Ala Val Thr Arg Ala Phe Ala Asp Arg His Val Pro Leu 
465                 470                 475                 480 


Glu Thr Val Thr Cys His Ala Pro Glu Ile His Ala Leu Tyr Glu Arg 
                485                 490                 495     


Ala His Val Leu Val Arg Pro Asp Gly His Val Ala Trp Arg Gly Asp 
            500                 505                 510         


His Leu Pro Ala Glu Leu Gly Gly Leu Val Asp Lys Val Arg Gly Ala 
        515                 520                 525             


Ala 
    


<210>  4
<211>  397
<212>  PRT
<213>  Lechevalieria aerocolonigenes

<400>  4

Met Lys Pro Phe Asp Leu Lys Ala Phe Thr Gly Ala Asp Leu Ala Asp 
1               5                   10                  15      


Pro Tyr Pro Val Tyr Arg Glu Tyr Leu Thr Gly Asp Pro Val His His 
            20                  25                  30          


Asn Gly Glu Ala Trp Tyr Val Phe Gly Tyr Asp Gly Val Ala His Val 
        35                  40                  45              


Leu Thr Ser Arg Asp Tyr Gly Arg Arg Gly Pro Gly Gly Arg Ala Thr 
    50                  55                  60                  


Pro Ile Pro Pro Ser His Asp Thr Leu Ser Arg Ile Val Glu Asn Trp 
65                  70                  75                  80  


Leu Val Phe Leu Asp Pro Pro Arg His Thr Ala Leu Arg Ser Leu Leu 
                85                  90                  95      


Ala Lys Glu Phe Ser Pro Ala Val Val Thr Gly Leu Arg Glu Arg Val 
            100                 105                 110         


Arg Lys Ile Ala Gly Glu Leu Leu Ala Gly Leu Gly Asp Ala Gly Glu 
        115                 120                 125             


Ile Asp Leu Val Glu Asp Phe Ala Ala Pro Leu Pro Ile Leu Val Ile 
    130                 135                 140                 


Ser Glu Leu Leu Gly Val Pro Ala Arg Leu Arg Ser Trp Phe Arg Arg 
145                 150                 155                 160 


Cys Ala Val Asp Leu Gln Glu Ala Ser Thr Ala Arg Ala Thr Arg Asn 
                165                 170                 175     


Pro Gly Ala Leu Ala Arg Ala Asp Gly Ala Ala Ser Glu Leu Val Glu 
            180                 185                 190         


Phe Phe Gly Gly Glu Leu Gly Thr Arg Lys Pro Asp Asp Glu Asp Leu 
        195                 200                 205             


Val Ala Leu Leu Val Asn Ala Gln Arg Arg Gly Glu Ala Leu Thr Asp 
    210                 215                 220                 


Glu Glu Ile Val Ser Thr Cys Val His Leu Leu Thr Ala Gly His Glu 
225                 230                 235                 240 


Thr Thr Thr Asn Leu Ile Ser Lys Ser Val Leu Ala Leu Leu Ala Asn 
                245                 250                 255     


Pro Ala Ala Ala Ala Glu Pro Leu Ala Gly Leu Asp Val Thr Pro Gln 
            260                 265                 270         


Val Val Glu Glu Leu Asn Arg Phe Asp Thr Pro Val Gln Met Val Thr 
        275                 280                 285             


Arg Trp Ala His Gln Asp Thr Ala Leu Gly Gly Lys Pro Ile Arg Arg 
    290                 295                 300                 


Gly Asp Lys Val Val Leu Val Leu Gly Ser Ala Asn Arg Asp Pro Ala 
305                 310                 315                 320 


Ala Phe Ala Glu Pro Asp Arg Leu Asp Leu Arg Arg Asp Ser Arg Arg 
                325                 330                 335     


His Cys Gly Phe Gly Leu Gly Ile His Tyr Cys Leu Gly Ala Ala Leu 
            340                 345                 350         


Ala Arg Thr Glu Ala Glu Ile Gly Leu Ser Val Leu Phe Thr Asn Phe 
        355                 360                 365             


Pro Gly Leu Arg Leu Gly Gly Glu Pro Val Arg Tyr Ala Asp Asp Leu 
    370                 375                 380                 


Val Phe His Gly Pro Ala Arg Leu Pro Met Leu Thr Arg 
385                 390                 395         


<210>  5
<211>  426
<212>  PRT
<213>  Streptomyces longisporoflavus DSM 10189

<400>  5

Met Pro Ser Ala Thr Leu Pro Arg Phe Asp Leu Met Gly Trp Asp Lys 
1               5                   10                  15      


Glu Asp Ile Ala His Pro Tyr Pro Val Tyr Arg Arg Tyr Arg Glu Ala 
            20                  25                  30          


Ala Pro Val His Arg Thr Ala Ala Gly Pro Gly Lys Pro Asp Thr Tyr 
        35                  40                  45              


Tyr Val Phe Thr Tyr Asp Asp Val Val Arg Val Leu Ser Asn Arg Arg 
    50                  55                  60                  


Phe Gly Arg Asn Ala Arg Val Ala Ser Gly Asp Thr Gly Pro Asp Thr 
65                  70                  75                  80  


Ala Pro Val Pro Ile Pro Ala Glu His Arg Ala Leu Arg Thr Val Val 
                85                  90                  95      


Glu Asn Trp Leu Val Phe Leu Asp Pro Pro Arg His Thr Glu Leu Arg 
            100                 105                 110         


Ser Leu Leu Thr Gly Glu Phe Ser Pro Ser Ile Val Thr Gly Leu Arg 
        115                 120                 125             


Pro Arg Ile Ala Glu Leu Ala Ser Glu Leu Leu Asp Arg Leu Arg Ala 
    130                 135                 140                 


His Arg Arg Pro Asp Leu Val Glu Gly Phe Ala Ala Pro Leu Pro Ile 
145                 150                 155                 160 


Leu Val Ile Ser Ala Leu Leu Gly Ile Pro Ala Glu Asp His Thr Trp 
                165                 170                 175     


Leu Arg Ala Asn Ala Val Ala Leu Gln Glu Ala Gly Thr Thr Arg Ser 
            180                 185                 190         


Arg Gly Gly His Gly Tyr Ala Arg Ala Glu Ala Ala Ser Gln Glu Phe 
        195                 200                 205             


Thr Arg Tyr Phe Arg Arg Glu Val Asp Arg Arg Gly Gly Asp Asp Arg 
    210                 215                 220                 


Asp Asp Leu Leu Thr Leu Leu Val Arg Ala Arg Asp Thr Gly Ser Pro 
225                 230                 235                 240 


Leu Ser Val Asp Gly Ile Val Gly Thr Cys Val His Leu Leu Thr Ala 
                245                 250                 255     


Gly His Glu Thr Thr Thr Asn Phe Leu Ala Lys Ala Val Leu Thr Leu 
            260                 265                 270         


Arg Ala His Pro Asp Val Leu Asp Glu Leu Arg Thr Thr Pro Glu Ser 
        275                 280                 285             


Thr Pro Ala Ala Val Glu Glu Leu Met Arg Tyr Asp Pro Pro Val Gln 
    290                 295                 300                 


Ala Val Thr Arg Trp Ala Tyr Glu Asp Ile Arg Leu Gly Asp His Asp 
305                 310                 315                 320 


Ile Pro Arg Gly Ser Arg Val Val Ala Leu Leu Gly Ser Ala Asn Arg 
                325                 330                 335     


Asp Pro Ala Arg Phe Pro Ala Pro Asp Val Leu Asp Val His Arg Ala 
            340                 345                 350         


Ala Glu Arg Gln Val Gly Phe Gly Leu Gly Ile His Tyr Cys Leu Gly 
        355                 360                 365             


Ala Thr Leu Ala Arg Ala Glu Ala Glu Ile Gly Leu Arg Ala Leu Leu 
    370                 375                 380                 


Asp Gly Ile Pro Ala Leu Gly Arg Gly Ala His Glu Val Glu Tyr Ala 
385                 390                 395                 400 


Asp Asp Met Val Phe His Gly Pro Thr Arg Leu Leu Leu Asp Leu Pro 
                405                 410                 415     


Asp Ala Thr Cys Pro Ser Ala Ser His Pro 
            420                 425     


<210>  6
<211>  545
<212>  PRT
<213>  Streptomyces longisporoflavus DSM 10189

<400>  6

Met Thr His Ser Gly Glu Arg Thr Asp Val Leu Ile Val Gly Gly Gly 
1               5                   10                  15      


Pro Val Gly Met Ala Leu Ala Leu Asp Leu Arg Tyr Arg Gly Ile Asp 
            20                  25                  30          


Cys Leu Val Val Asp Ala Gly Asp Gly Thr Val Arg His Pro Lys Val 
        35                  40                  45              


Ser Thr Ile Gly Pro Arg Ser Met Glu Leu Phe Arg Arg Trp Gly Ala 
    50                  55                  60                  


Ala Asp Ala Ile Arg Asn Ala Gly Trp Pro Ala Asp His Pro Leu Asp 
65                  70                  75                  80  


Ile Ala Trp Val Thr Lys Val Gly Gly His Glu Ile Tyr Arg Tyr Arg 
                85                  90                  95      


Arg Gly Thr Ala Ala Asn Arg Pro Ala Phe Val His Thr Pro Glu Pro 
            100                 105                 110         


Asp Gln Ile Cys Pro Ala His Trp Leu Asn Pro Val Leu Ile Glu Ala 
        115                 120                 125             


Val Gly Val His Pro Asp Gly Pro Leu Leu Leu Ser Thr Thr Val Asp 
    130                 135                 140                 


Gly Val Val Gln Thr Asp Asp His Val Glu Ala Thr Leu Thr Asp His 
145                 150                 155                 160 


Ala Thr Gly Thr Thr Gly Thr Val Arg Ala Arg Phe Leu Val Ala Cys 
                165                 170                 175     


Asp Gly Ala Ser Ser Pro Val Arg Arg Ala Cys Gly Ile Glu Ala Pro 
            180                 185                 190         


Ala Arg His Arg Thr Gln Val Phe Arg Asn Ile Leu Phe Arg Ala Pro 
        195                 200                 205             


Glu Leu Lys Asp Arg Leu Gly Glu Arg Ala Ala Leu Val His Phe Leu 
    210                 215                 220                 


Met Leu Ser Ser Thr Leu Arg Phe Pro Leu Arg Ser Leu Asn Gly Ser 
225                 230                 235                 240 


Asp Leu Tyr Asn Leu Val Val Gly Ala Asp Asp Asp Thr Gly Ala Arg 
                245                 250                 255     


Pro Asp Ala Leu Ala Leu Ile Lys Asp Ala Leu Ala Leu Asp Thr Pro 
            260                 265                 270         


Val Glu Leu Leu Gly Asp Ser Ala Trp Arg Leu Thr His Arg Val Ala 
        275                 280                 285             


Asp Arg Tyr Arg Ala Gly Arg Ile Phe Leu Ala Gly Asp Ala Ala His 
    290                 295                 300                 


Thr Leu Ser Pro Ser Gly Gly Phe Gly Leu Asn Thr Gly Ile Gly Asp 
305                 310                 315                 320 


Ala Ala Asp Leu Gly Trp Lys Leu Ala Ala Thr Leu Asp Gly Trp Ala 
                325                 330                 335     


Gly Arg His Leu Leu Asp Thr Tyr Asp Ser Glu Arg Arg Pro Ile Ala 
            340                 345                 350         


Glu Glu Ser Leu Asn Glu Ala His Asp Asn Leu Arg Arg Thr Met Lys 
        355                 360                 365             


Arg Glu Val Pro Pro Glu Ile His Leu Asp Gly Pro Glu Gly Glu Arg 
    370                 375                 380                 


Ala Arg Ala Val Met Ala Arg Arg Leu Glu Asn Ser Gly Ala Arg Arg 
385                 390                 395                 400 


Glu Phe Asp Ala Pro Gln Ile His Phe Gly Leu Arg Tyr Arg Ser Ser 
                405                 410                 415     


Ala Ile Val Asp Asp Pro Asp Val Pro Val Arg Gln Gly Gln Pro Asp 
            420                 425                 430         


Ala Asp Trp Arg Pro Gly Ser Glu Pro Gly Tyr Arg Ala Ala His Ala 
        435                 440                 445             


Trp Trp Asp Ser Thr Thr Ser Thr Leu Asp Leu Phe Gly Arg Gly Phe 
    450                 455                 460                 


Val Leu Leu Arg Phe Ala Asp His Asp Gly Leu Pro Ala Ile Glu Arg 
465                 470                 475                 480 


Ala Phe Ala Glu Arg Gly Val Pro Leu Thr Val His Gln Gly His Asp 
                485                 490                 495     


Thr Glu Ile Ala Lys Leu Tyr Ala Arg Ser Phe Val Leu Val Arg Pro 
            500                 505                 510         


Asp Gly His Val Ala Trp Arg Gly Asp Asp Leu Pro Gly Asp Pro Thr 
        515                 520                 525             


Ala Leu Val Asp Thr Val Arg Gly Glu Ala Ala Pro Arg Glu Pro Arg 
    530                 535                 540                 


Gly 
545 


<210>  7
<211>  445
<212>  PRT
<213>  Uncultured bacterium

<400>  7

Met Leu Ser Ala Glu Asp Asn Lys Leu Leu Thr Glu Val Ala Ala Asp 
1               5                   10                  15      


Thr Arg Met Gly Gln Leu Leu Arg Arg Tyr Trp His Pro Ile Ala Ala 
            20                  25                  30          


Ser Ser Gln Leu Asp Asp Lys His Pro Thr Arg Leu Val His Leu Leu 
        35                  40                  45              


Gly Glu Lys Leu Val Leu Tyr Lys Asp Lys Gln Gly Arg Leu Gly Leu 
    50                  55                  60                  


Ile Asp Glu Arg Cys Pro His Arg Arg Ala Ser Met Leu Tyr Gly Ile 
65                  70                  75                  80  


Pro Glu Gln Glu Gly Leu Arg Cys Ser Tyr His Gly Trp Leu Phe Asn 
                85                  90                  95      


Asn Ala Gly Arg Cys Leu Ala Gln Pro Tyr Glu Gln Met Glu Asp Pro 
            100                 105                 110         


Cys Ser Asn Phe Lys Asp His Val Arg Ile Lys Ser Tyr Pro Val Arg 
        115                 120                 125             


Glu Leu Gly Gly Leu Val Phe Ala Tyr Leu Gly Pro Ala Pro Ala Pro 
    130                 135                 140                 


Glu Leu Pro Ala Trp Asp Leu Leu Val Thr Glu Asn Leu His Arg Asp 
145                 150                 155                 160 


Ile Gly Phe Ala Val Val Pro Cys Asn Trp Leu Gln Ile Met Glu Asn 
                165                 170                 175     


Ala Ala Asp Pro Val His Ala Glu Trp Leu His Gly His Phe Ala Asn 
            180                 185                 190         


Tyr Val Trp Glu Arg Leu Gly Lys Pro Glu Arg Ile Lys Pro Phe Pro 
        195                 200                 205             


Thr His Lys Lys Ile Gly Phe Asp Leu Ser Glu Tyr Gly Ile Ile Lys 
    210                 215                 220                 


Arg Arg Val Leu Glu Gly Glu Thr Glu Glu His Glu Asn Trp Lys Phe 
225                 230                 235                 240 


Gly His Ser Leu Val Phe Pro Asn Leu Gln Lys Gly Gly Gly Leu Gln 
                245                 250                 255     


Trp Arg Val Pro Met Asp Glu Thr Arg Thr Leu His Val Trp Tyr Tyr 
            260                 265                 270         


Thr Tyr Thr Pro Ala Glu Gly Thr Val Val Pro Lys Asp Ala Pro Ile 
        275                 280                 285             


Pro Val Phe Asp Val Pro Val Pro Ala Leu Asp Glu His Gly His Pro 
    290                 295                 300                 


Arg Trp Asp Val Leu Asp Phe Thr Ala Gly Gln Asp Met Val Met Trp 
305                 310                 315                 320 


Tyr Thr Gln Gly Ala Val Ala Glu Arg Trp Lys Glu Thr Leu Gly Arg 
                325                 330                 335     


Ser Asp Arg Gly Val Ile Met Tyr Arg Asn Leu Leu Lys Ala Asn Leu 
            340                 345                 350         


Glu Lys Leu Ala Arg Gly Glu Glu Pro Met Asn Val Phe Arg Asp Pro 
        355                 360                 365             


Ala Lys Ala Ala Phe Ile Gln Leu Asp Thr Glu Glu Ser Ser Gly Arg 
    370                 375                 380                 


Arg Leu Tyr Ser Asp Arg Ala Arg Gln Tyr Gly Pro Ser Ser Ser Asn 
385                 390                 395                 400 


Gly Pro Gly Gly Gly Ala Thr Lys Tyr Ser Pro Val Leu Asn Leu His 
                405                 410                 415     


Lys Gly Ala Glu Thr Val Ser Ala Lys Glu Val Met Pro Glu Thr Ala 
            420                 425                 430         


Leu Pro Ala Ala Pro Pro Ala Ala Arg Lys Glu Thr Ala 
        435                 440                 445 


