                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc.
       The U.S.A., as represented by the Secretary, Department of 
       Health and Human Services
 
<120>  Compositions and Methods for Treating Cancer with Anti-ROR1 
       Immunotherapy

<130>  42449-0018WO1

<150>  US 62/581,284
<151>  2017-11-03

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of Anti-ROR1 binder: ScFV4

<400>  1
caggtgcagc tgcaggagtc cggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atacccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagacac      300

ctggggggtg atgcttttga tatctggggc caagggacca cggtcaccgt ctcctcagga      360

ggtggcgggt ctggtggtgg cggtagcggt ggaggcggat ccctgcctgt gctgactcag      420

cccccctcgg tgtcagtggc cccaggacag acggccagga ttacctgtgg ggggaacaac      480

attggaagta aaagtgtgca ctggtaccag cagaagccag gccaggcccc tgtgctggtc      540

gtctatgatg atagcgaccg gccctcaggg atccctgagc gattctctgg ctccaactct      600

gggaacacag ccactctgac catcagcggg acccaggcta tggatgaggc tgactacttc      660

tgtcagtctt atgatagcag caatcccgtg gtattcggcg gagggaccca gctcaccgtt      720

tta                                                                    723


<210>  2
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Anti-ROR1 binder: ScFV4

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Pro Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg His Leu Gly Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Leu Pro Val Leu Thr Gln Pro Pro Ser Val 
    130                 135                 140                 


Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn 
145                 150                 155                 160 


Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Phe Cys Gln Ser Tyr 
    210                 215                 220                 


Asp Ser Ser Asn Pro Val Val Phe Gly Gly Gly Thr Gln Leu Thr Val 
225                 230                 235                 240 


Leu 
    


<210>  3
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP-ScFV4-CD8H/CD8TM-41BB-CD3zeta

<400>  3
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag ttcagctgca agaatcagga cctgggcttg tcaaaccatc tgaaaccctc      120

agcttgactt gtaccgtatc aggagggtca atttcaagct catcctacta ttggggatgg      180

atcagacaac cacccgggaa agggctcgag tggatagggt ccatatatta cagcggatct      240

acatactaca acccgtcatt gaagtccagg gtaacgattc cggtggacac tagcaagaat      300

cagtttagcc tcaagttgag cagtgtaact gctgcggaca cggcggtata ttattgtgct      360

cgacacctcg gtggagatgc ttttgacata tggggtcaag ggacaacagt caccgttagc      420

tcaggtggag ggggtagcgg ggggggcgga tctgggggag gcggttcatt gcccgtactt      480

acacagccac cctctgtcag cgtcgcacct ggacaaaccg ctcgcatcac ctgtggcgga      540

aataatatag gttccaagtc tgttcattgg tatcagcaga aaccgggaca ggcccccgtc      600

cttgtggtgt atgatgattc tgataggcca tctggtatcc cagaacggtt ttcaggtagc      660

aattcaggga atactgccac tctcactatt agcggtactc aagctatgga tgaggccgac      720

tatttttgcc agagctacga ctctagtaac ccagtcgtgt tcgggggagg gacccagttg      780

accgtgctgg cggccgcaac taccacccct gcccctcggc cgccgactcc ggccccaacc      840

atcgcaagcc aacccctctc cttgcgcccc gaagcttgcc gcccggccgc gggtggagcc      900

gtgcataccc gggggctgga ctttgcctgc gatatctaca tttgggcccc gctggccggc      960

acttgcggcg tgctcctgct gtcgctggtc atcacccttt actgcaagag gggccggaag     1020

aagctgcttt acatcttcaa gcagccgttc atgcggcccg tgcagacgac tcaggaagag     1080

gacggatgct cgtgcagatt ccctgaggag gaagaggggg gatgcgaact gcgcgtcaag     1140

ttctcacggt ccgccgacgc ccccgcatat caacagggcc agaatcagct ctacaacgag     1200

ctgaacctgg gaaggagaga ggagtacgac gtgctggaca agcgacgcgg acgcgacccg     1260

gagatggggg ggaaaccacg gcggaaaaac cctcaggaag gactgtacaa cgaactccag     1320

aaagacaaga tggcggaagc ctactcagaa atcgggatga agggagagcg gaggagggga     1380

aagggtcacg acgggctgta ccagggactg agcaccgcca ctaaggatac ctacgatgcc     1440

ttgcatatgc aagcactccc accccgg                                         1467


<210>  4
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LP-ScFV4-CD8H/CD8TM-41BB-CD3zeta

<400>  4

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Pro Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Leu Gly Gly Asp Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Val Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
                165                 170                 175     


Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp 
        195                 200                 205             


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
    210                 215                 220                 


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Ser Tyr Asp Ser Ser Asn Pro Val Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Gln Leu Thr Val Leu Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  5
<211>  1368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP-ScFV4-IgG4H/CD8TM-41BB-CD3zeta

<400>  5
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag ttcagctgca agaatcagga cctgggcttg tcaaaccatc tgaaaccctc      120

agcttgactt gtaccgtatc aggagggtca atttcaagct catcctacta ttggggatgg      180

atcagacaac cacccgggaa agggctcgag tggatagggt ccatatatta cagcggatct      240

acatactaca acccgtcatt gaagtccagg gtaacgattc cggtggacac tagcaagaat      300

cagtttagcc tcaagttgag cagtgtaact gctgcggaca cggcggtata ttattgtgct      360

cgacacctcg gtggagatgc ttttgacata tggggtcaag ggacaacagt caccgttagc      420

tcaggtggag ggggtagcgg ggggggcgga tctgggggag gcggttcatt gcccgtactt      480

acacagccac cctctgtcag cgtcgcacct ggacaaaccg ctcgcatcac ctgtggcgga      540

aataatatag gttccaagtc tgttcattgg tatcagcaga aaccgggaca ggcccccgtc      600

cttgtggtgt atgatgattc tgataggcca tctggtatcc cagaacggtt ttcaggtagc      660

aattcaggga atactgccac tctcactatt agcggtactc aagctatgga tgaggccgac      720

tatttttgcc agagctacga ctctagtaac ccagtcgtgt tcgggggagg gacccagttg      780

accgtgctgg cggccgcaga gtcaaaatac ggtcctccgt gccctccgtg tccgatctac      840

atttgggccc cgctggccgg cacttgcggc gtgctcctgc tgtcgctggt catcaccctt      900

tactgcaaga ggggccggaa gaagctgctt tacatcttca agcagccgtt catgcggccc      960

gtgcagacga ctcaggaaga ggacggatgc tcgtgcagat tccctgagga ggaagagggg     1020

ggatgcgaac tgcgcgtcaa gttctcacgg tccgccgacg cccccgcata tcaacagggc     1080

cagaatcagc tctacaacga gctgaacctg ggaaggagag aggagtacga cgtgctggac     1140

aagcgacgcg gacgcgaccc ggagatgggg gggaaaccac ggcggaaaaa ccctcaggaa     1200

ggactgtaca acgaactcca gaaagacaag atggcggaag cctactcaga aatcgggatg     1260

aagggagagc ggaggagggg aaagggtcac gacgggctgt accagggact gagcaccgcc     1320

actaaggata cctacgatgc cttgcatatg caagcactcc caccccgg                  1368


<210>  6
<211>  455
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LP-ScFV4-IgG4H/CD8TM-41BB-CD3zeta

<400>  6

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Gln Glu Ser Gly Pro Gly 
            20                  25                  30          


Leu Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly 
        35                  40                  45              


Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser 
65                  70                  75                  80  


Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Pro Val Asp 
                85                  90                  95      


Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Leu Gly Gly Asp Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Pro Val Leu 
145                 150                 155                 160 


Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile 
                165                 170                 175     


Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp 
        195                 200                 205             


Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn 
    210                 215                 220                 


Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Phe Cys Gln Ser Tyr Asp Ser Ser Asn Pro Val Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Gln Leu Thr Val Leu Ala Ala Ala Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
        275                 280                 285             


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             


Met Gln Ala Leu Pro Pro Arg 
    450                 455 


<210>  7
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of Anti-ROR1 binder: ScFV9

<400>  7
caggcggccc aggtacagct gcagcagtca ggggctgagg tgaagaagcc tgggtcctcg       60

gtgaaggtct cctgcaaggc ttctggaggc accttcagca gctatgctat cagctgggtg      120

cgacaggccc ctggacaagg gcttgagtgg atgggatgga tcaaccctaa cagtggtggc      180

acaaactatg cacagaggtt tcagggcagg gtcaccatga ccagggacac gtccatcagc      240

acagcctaca tggagctgag caggctgaga tctgacgaca cggccgtgta ttactgtgcg      300

agttataatg atgcttttga tatctggggc caaggcaccc tggtcaccgt ctcctcagga      360

ggtggcgggt ctggtggtgg cggtagcggt ggtggcggat ccaattttat gctgactcag      420

ccccactctg tgtcggagtc tccggggaag acggtaacca tctcctgcac ccgcagcagt      480

ggcagcattg ccagcaacta tgtgcagtgg taccagcagc gcccgggcag tgcccccacc      540

attgtgatct atgaggatga tcaaagaccc tctggggtcc ctgatcggtt ctctggctcc      600

atcgacacct cctccaactc tgcctccctc accatctctg gactgcagag tgaggacgag      660

gctgactact actgtcagtc ttatgagccc ggcaatgggg tattcggcgg agggaccaag      720

gtcaccgtcc ta                                                          732


<210>  8
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of Anti-ROR1 binder: ScFV9

<400>  8

Gln Ala Ala Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys 
1               5                   10                  15      


Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe 
            20                  25                  30          


Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala 
    50                  55                  60                  


Gln Arg Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser 
65                  70                  75                  80  


Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ser Tyr Asn Asp Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln Pro His Ser Val 
    130                 135                 140                 


Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Ser Ser 
145                 150                 155                 160 


Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly 
                165                 170                 175     


Ser Ala Pro Thr Ile Val Ile Tyr Glu Asp Asp Gln Arg Pro Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Thr Ser Ser Asn Ser Ala 
        195                 200                 205             


Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gln Ser Tyr Glu Pro Gly Asn Gly Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Thr Val Leu 
                


<210>  9
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP-ScFV9-CD8H/CD8TM-41BB-CD3zeta

<400>  9
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcagg cggcccaggt acagctgcag cagtcagggg ctgaggtgaa gaagcctggg      120

tcctcggtga aggtctcctg caaggcttct ggaggcacct tcagcagcta tgctatcagc      180

tgggtgcgac aggcccctgg acaagggctt gagtggatgg gatggatcaa ccctaacagt      240

ggtggcacaa actatgcaca gaggtttcag ggcagggtca ccatgaccag ggacacgtcc      300

atcagcacag cctacatgga gctgagcagg ctgagatctg acgacacggc cgtgtattac      360

tgtgcgagtt ataatgatgc ttttgatatc tggggccaag gcaccctggt caccgtctcc      420

tcaggaggtg gcgggtctgg tggtggcggt agcggtggtg gcggatccaa ttttatgctg      480

actcagcccc actctgtgtc ggagtctccg gggaagacgg taaccatctc ctgcacccgc      540

agcagtggca gcattgccag caactatgtg cagtggtacc agcagcgccc gggcagtgcc      600

cccaccattg tgatctatga ggatgatcaa agaccctctg gggtccctga tcggttctct      660

ggctccatcg acacctcctc caactctgcc tccctcacca tctctggact gcagagtgag      720

gacgaggctg actactactg tcagtcttat gagcccggca atggggtatt cggcggaggg      780

accaaggtca ccgtcctagc ggccgcaact accacccctg cccctcggcc gccgactccg      840

gccccaacca tcgcaagcca acccctctcc ttgcgccccg aagcttgccg cccggccgcg      900

ggtggagccg tgcatacccg ggggctggac tttgcctgcg atatctacat ttgggccccg      960

ctggccggca cttgcggcgt gctcctgctg tcgctggtca tcacccttta ctgcaagagg     1020

ggccggaaga agctgcttta catcttcaag cagccgttca tgcggcccgt gcagacgact     1080

caggaagagg acggatgctc gtgcagattc cctgaggagg aagagggggg atgcgaactg     1140

cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc     1200

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga     1260

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac     1320

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg     1380

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc     1440

tacgatgcct tgcatatgca agcactccca ccccgg                               1476


<210>  10
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LP-ScFV9-CD8H/CD8TM-41BB-CD3zeta

<400>  10

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ala Ala Gln Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser 
65                  70                  75                  80  


Gly Gly Thr Asn Tyr Ala Gln Arg Phe Gln Gly Arg Val Thr Met Thr 
                85                  90                  95      


Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
            100                 105                 110         


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Tyr Asn Asp Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu 
145                 150                 155                 160 


Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile 
                165                 170                 175     


Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Val Ile Tyr Glu Asp 
        195                 200                 205             


Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 
    210                 215                 220                 


Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Glu Pro Gly Asn Gly Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  11
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP-ScFV9-IgG4H/CD8TM-41BB-CD3zeta

<400>  11
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcagg cggcccaggt acagctgcag cagtcagggg ctgaggtgaa gaagcctggg      120

tcctcggtga aggtctcctg caaggcttct ggaggcacct tcagcagcta tgctatcagc      180

tgggtgcgac aggcccctgg acaagggctt gagtggatgg gatggatcaa ccctaacagt      240

ggtggcacaa actatgcaca gaggtttcag ggcagggtca ccatgaccag ggacacgtcc      300

atcagcacag cctacatgga gctgagcagg ctgagatctg acgacacggc cgtgtattac      360

tgtgcgagtt ataatgatgc ttttgatatc tggggccaag gcaccctggt caccgtctcc      420

tcaggaggtg gcgggtctgg tggtggcggt agcggtggtg gcggatccaa ttttatgctg      480

actcagcccc actctgtgtc ggagtctccg gggaagacgg taaccatctc ctgcacccgc      540

agcagtggca gcattgccag caactatgtg cagtggtacc agcagcgccc gggcagtgcc      600

cccaccattg tgatctatga ggatgatcaa agaccctctg gggtccctga tcggttctct      660

ggctccatcg acacctcctc caactctgcc tccctcacca tctctggact gcagagtgag      720

gacgaggctg actactactg tcagtcttat gagcccggca atggggtatt cggcggaggg      780

accaaggtca ccgtcctagc ggccgcagag tcaaaatacg gtcctccgtg ccctccgtgt      840

ccgatctaca tttgggcccc gctggccggc acttgcggcg tgctcctgct gtcgctggtc      900

atcacccttt actgcaagag gggccggaag aagctgcttt acatcttcaa gcagccgttc      960

atgcggcccg tgcagacgac tcaggaagag gacggatgct cgtgcagatt ccctgaggag     1020

gaagaggggg gatgcgaact gcgcgtcaag ttctcacggt ccgccgacgc ccccgcatat     1080

caacagggcc agaatcagct ctacaacgag ctgaacctgg gaaggagaga ggagtacgac     1140

gtgctggaca agcgacgcgg acgcgacccg gagatggggg ggaaaccacg gcggaaaaac     1200

cctcaggaag gactgtacaa cgaactccag aaagacaaga tggcggaagc ctactcagaa     1260

atcgggatga agggagagcg gaggagggga aagggtcacg acgggctgta ccagggactg     1320

agcaccgcca ctaaggatac ctacgatgcc ttgcatatgc aagcactccc accccgg        1377


<210>  12
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LP-ScFV9-IgG4H/CD8TM-41BB-CD3zeta

<400>  12

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Ala Ala Gln Val Gln Leu Gln Gln Ser 
            20                  25                  30          


Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val Lys Val Ser Cys Lys 
        35                  40                  45              


Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala Ile Ser Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser 
65                  70                  75                  80  


Gly Gly Thr Asn Tyr Ala Gln Arg Phe Gln Gly Arg Val Thr Met Thr 
                85                  90                  95      


Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg 
            100                 105                 110         


Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ser Tyr Asn Asp Ala Phe 
        115                 120                 125             


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu 
145                 150                 155                 160 


Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile 
                165                 170                 175     


Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp 
            180                 185                 190         


Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Ile Val Ile Tyr Glu Asp 
        195                 200                 205             


Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 
    210                 215                 220                 


Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Glu Pro Gly Asn Gly Val 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Val Thr Val Leu Ala Ala Ala Glu Ser Lys 
            260                 265                 270         


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Tyr Ile Trp Ala Pro Leu 
        275                 280                 285             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    290                 295                 300                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
305                 310                 315                 320 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                325                 330                 335     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  13
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of CONTROL ANTI-ROR1 binder

<400>  13
caagaacagc ttgtagagtc cggcggtaga ttggtgacac cgggggggag ccttaccctg       60

tcttgtaagg catctgggtt cgatttcagt gcgtattata tgagctgggt tcggcaggcg      120

cccgggaagg ggctggaatg gatagccact atatacccgt catccggcaa gacttactac      180

gcgacttggg taaacgggag gtttacgata agctcagata acgcccaaaa cacggttgat      240

ctccaaatga atagcttgac cgccgctgat agggcgacct atttctgtgc gcgggactct      300

tacgctgatg acggggccct cttcaatata tggggaccgg gaacgctcgt aaccatatca      360

tctggaggag gtgggagcgg aggcggaggg tcaggtgggg gcgggagcga actcgtactt      420

acacaatctc caagcgtaag cgcagcgttg gggagtccag caaagatcac ctgcactttg      480

tcaagcgccc acaaaacgga tacgatagat tggtatcagc aactccaagg tgaagcgcca      540

cgatatctca tgcaggtaca gagcgacggg agttatacta agaggcccgg ggtcccagac      600

agattcagtg gcagcagttc aggtgccgac agatacctga taataccctc agttcaagcc      660

gatgatgaag ccgattacta ctgtggggct gactacatag gtgggtatgt tttcgggggc      720

ggcactcaat tgacagttac aggg                                             744


<210>  14
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CONTROL ANTI-ROR1 binder

<400>  14

Gln Glu Gln Leu Val Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly Phe Asp Phe Ser Ala Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr Tyr Tyr Ala Thr Trp Val 
    50                  55                  60                  


Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Gln Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Ala Asp Arg Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala Leu Phe Asn Ile Trp Gly 
            100                 105                 110         


Pro Gly Thr Leu Val Thr Ile Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Val Ser Ala Ala Leu Gly Ser Pro Ala Lys Ile Thr Cys Thr Leu 
145                 150                 155                 160 


Ser Ser Ala His Lys Thr Asp Thr Ile Asp Trp Tyr Gln Gln Leu Gln 
                165                 170                 175     


Gly Glu Ala Pro Arg Tyr Leu Met Gln Val Gln Ser Asp Gly Ser Tyr 
            180                 185                 190         


Thr Lys Arg Pro Gly Val Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val Gln Ala Asp Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly Gly Tyr Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Gln Leu Thr Val Thr Gly 
                245             


<210>  15
<211>  1488
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP-ControlScFv-CD8H/CD8TM-41BB-CD3zeta

<400>  15
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag aacagcttgt agagtccggc ggtagattgg tgacaccggg ggggagcctt      120

accctgtctt gtaaggcatc tgggttcgat ttcagtgcgt attatatgag ctgggttcgg      180

caggcgcccg ggaaggggct ggaatggata gccactatat acccgtcatc cggcaagact      240

tactacgcga cttgggtaaa cgggaggttt acgataagct cagataacgc ccaaaacacg      300

gttgatctcc aaatgaatag cttgaccgcc gctgataggg cgacctattt ctgtgcgcgg      360

gactcttacg ctgatgacgg ggccctcttc aatatatggg gaccgggaac gctcgtaacc      420

atatcatctg gaggaggtgg gagcggaggc ggagggtcag gtgggggcgg gagcgaactc      480

gtacttacac aatctccaag cgtaagcgca gcgttgggga gtccagcaaa gatcacctgc      540

actttgtcaa gcgcccacaa aacggatacg atagattggt atcagcaact ccaaggtgaa      600

gcgccacgat atctcatgca ggtacagagc gacgggagtt atactaagag gcccggggtc      660

ccagacagat tcagtggcag cagttcaggt gccgacagat acctgataat accctcagtt      720

caagccgatg atgaagccga ttactactgt ggggctgact acataggtgg gtatgttttc      780

gggggcggca ctcaattgac agttacaggg gcggccgcaa ctaccacccc tgcccctcgg      840

ccgccgactc cggccccaac catcgcaagc caacccctct ccttgcgccc cgaagcttgc      900

cgcccggccg cgggtggagc cgtgcatacc cgggggctgg actttgcctg cgatatctac      960

atttgggccc cgctggccgg cacttgcggc gtgctcctgc tgtcgctggt catcaccctt     1020

tactgcaaga ggggccggaa gaagctgctt tacatcttca agcagccgtt catgcggccc     1080

gtgcagacga ctcaggaaga ggacggatgc tcgtgcagat tccctgagga ggaagagggg     1140

ggatgcgaac tgcgcgtcaa gttctcacgg tccgccgacg cccccgcata tcaacagggc     1200

cagaatcagc tctacaacga gctgaacctg ggaaggagag aggagtacga cgtgctggac     1260

aagcgacgcg gacgcgaccc ggagatgggg gggaaaccac ggcggaaaaa ccctcaggaa     1320

ggactgtaca acgaactcca gaaagacaag atggcggaag cctactcaga aatcgggatg     1380

aagggagagc ggaggagggg aaagggtcac gacgggctgt accagggact gagcaccgcc     1440

actaaggata cctacgatgc cttgcatatg caagcactcc caccccgg                  1488


<210>  16
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LP-ControlScFv-CD8H/CD8TM-41BB-CD3zeta

<400>  16

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Glu Gln Leu Val Glu Ser Gly Gly Arg 
            20                  25                  30          


Leu Val Thr Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Asp Phe Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr 
65                  70                  75                  80  


Tyr Tyr Ala Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ala Gln Asn Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp 
            100                 105                 110         


Arg Ala Thr Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala 
        115                 120                 125             


Leu Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser Pro Ala 
                165                 170                 175     


Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
            180                 185                 190         


Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val 
        195                 200                 205             


Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val 
225                 230                 235                 240 


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly 
                245                 250                 255     


Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Ala Ala 
            260                 265                 270         


Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
        275                 280                 285             


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
    290                 295                 300                 


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
305                 310                 315                 320 


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
                325                 330                 335     


Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495     


<210>  17
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LP-ControlScFv-IgG4H/CD8TM-41BB-CD3zeta

<400>  17
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcaag aacagcttgt agagtccggc ggtagattgg tgacaccggg ggggagcctt      120

accctgtctt gtaaggcatc tgggttcgat ttcagtgcgt attatatgag ctgggttcgg      180

caggcgcccg ggaaggggct ggaatggata gccactatat acccgtcatc cggcaagact      240

tactacgcga cttgggtaaa cgggaggttt acgataagct cagataacgc ccaaaacacg      300

gttgatctcc aaatgaatag cttgaccgcc gctgataggg cgacctattt ctgtgcgcgg      360

gactcttacg ctgatgacgg ggccctcttc aatatatggg gaccgggaac gctcgtaacc      420

atatcatctg gaggaggtgg gagcggaggc ggagggtcag gtgggggcgg gagcgaactc      480

gtacttacac aatctccaag cgtaagcgca gcgttgggga gtccagcaaa gatcacctgc      540

actttgtcaa gcgcccacaa aacggatacg atagattggt atcagcaact ccaaggtgaa      600

gcgccacgat atctcatgca ggtacagagc gacgggagtt atactaagag gcccggggtc      660

ccagacagat tcagtggcag cagttcaggt gccgacagat acctgataat accctcagtt      720

caagccgatg atgaagccga ttactactgt ggggctgact acataggtgg gtatgttttc      780

gggggcggca ctcaattgac agttacaggg gcggccgcag agtcaaaata cggtcctccg      840

tgccctccgt gtccgatcta catttgggcc ccgctggccg gcacttgcgg cgtgctcctg      900

ctgtcgctgg tcatcaccct ttactgcaag aggggccgga agaagctgct ttacatcttc      960

aagcagccgt tcatgcggcc cgtgcagacg actcaggaag aggacggatg ctcgtgcaga     1020

ttccctgagg aggaagaggg gggatgcgaa ctgcgcgtca agttctcacg gtccgccgac     1080

gcccccgcat atcaacaggg ccagaatcag ctctacaacg agctgaacct gggaaggaga     1140

gaggagtacg acgtgctgga caagcgacgc ggacgcgacc cggagatggg ggggaaacca     1200

cggcggaaaa accctcagga aggactgtac aacgaactcc agaaagacaa gatggcggaa     1260

gcctactcag aaatcgggat gaagggagag cggaggaggg gaaagggtca cgacgggctg     1320

taccagggac tgagcaccgc cactaaggat acctacgatg ccttgcatat gcaagcactc     1380

ccaccccgg                                                             1389


<210>  18
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LP-ControlScFv-IgG4H/CD8TM-41BB-CD3zeta

<400>  18

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Glu Gln Leu Val Glu Ser Gly Gly Arg 
            20                  25                  30          


Leu Val Thr Pro Gly Gly Ser Leu Thr Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Asp Phe Ser Ala Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Ile Ala Thr Ile Tyr Pro Ser Ser Gly Lys Thr 
65                  70                  75                  80  


Tyr Tyr Ala Thr Trp Val Asn Gly Arg Phe Thr Ile Ser Ser Asp Asn 
                85                  90                  95      


Ala Gln Asn Thr Val Asp Leu Gln Met Asn Ser Leu Thr Ala Ala Asp 
            100                 105                 110         


Arg Ala Thr Tyr Phe Cys Ala Arg Asp Ser Tyr Ala Asp Asp Gly Ala 
        115                 120                 125             


Leu Phe Asn Ile Trp Gly Pro Gly Thr Leu Val Thr Ile Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Leu 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ser Pro Ala 
                165                 170                 175     


Lys Ile Thr Cys Thr Leu Ser Ser Ala His Lys Thr Asp Thr Ile Asp 
            180                 185                 190         


Trp Tyr Gln Gln Leu Gln Gly Glu Ala Pro Arg Tyr Leu Met Gln Val 
        195                 200                 205             


Gln Ser Asp Gly Ser Tyr Thr Lys Arg Pro Gly Val Pro Asp Arg Phe 
    210                 215                 220                 


Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro Ser Val 
225                 230                 235                 240 


Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Tyr Ile Gly 
                245                 250                 255     


Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly Ala Ala 
            260                 265                 270         


Ala Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Tyr Ile 
        275                 280                 285             


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    290                 295                 300                 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
305                 310                 315                 320 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                325                 330                 335     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  19
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of leader/signal peptide sequence (LP)

<400>  19
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of leader/signal peptide sequence (LP)

<400>  20

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  21
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  21
atttgggccc cgctggccgg cacttgcggc gtgctcctgc tgtcgctggt catcaccctt       60

tactgc                                                                  66


<210>  22
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  23
<211>  141
<212>  DNA
<213>  Homo sapiens

<400>  23
actaccaccc ctgcccctcg gccgccgact ccggccccaa ccatcgcaag ccaacccctc       60

tccttgcgcc ccgaagcttg ccgcccggcc gcgggtggag ccgtgcatac ccgggggctg      120

gactttgcct gcgatatcta c                                                141


<210>  24
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  25
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  25

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  26
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  26
aagaggggcc ggaagaagct gctttacatc ttcaagcagc cgttcatgcg gcccgtgcag       60

acgactcagg aagaggacgg atgctcgtgc agattccctg aggaggaaga ggggggatgc      120

gaactg                                                                 126


<210>  27
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  27

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  28
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  28
cgcgtcaagt tctcacggtc cgccgacgcc cccgcatatc aacagggcca gaatcagctc       60

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga      120

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac      180

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg      240

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc      300

tacgatgcct tgcatatgca agcactccca ccccgg                                336


<210>  29
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  30
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of intracellular signaling domain of 
       CD3-zeta, variant

<400>  30
cgcgtcaagt tctcacggtc cgccgacgcc cccgcatata aacagggcca gaatcagctc       60

tacaacgagc tgaacctggg aaggagagag gagtacgacg tgctggacaa gcgacgcgga      120

cgcgacccgg agatgggggg gaaaccacgg cggaaaaacc ctcaggaagg actgtacaac      180

gaactccaga aagacaagat ggcggaagcc tactcagaaa tcgggatgaa gggagagcgg      240

aggaggggaa agggtcacga cgggctgtac cagggactga gcaccgccac taaggatacc      300

tacgatgcct tgcatatgca agcactccca ccccgg                                336


<210>  31
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of CD3-zeta signaling domain, variant

<400>  31

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  32
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of ScFV CD19 (FMC63)

<400>  32
gacattcaga tgactcagac cacctcttcc ttgtccgcgt cactgggaga cagagtgacc       60

atctcgtgtc gcgcaagcca ggatatctcc aagtacctga actggtacca acagaagccc      120

gacgggactg tgaagctgct gatctaccac acctcacgcc tgcacagcgg agtgccaagc      180

agattctccg gctccggctc gggaaccgat tactcgctta ccattagcaa cctcgagcag      240

gaggacatcg ctacctactt ctgccagcaa ggaaataccc tgccctacac cttcggcgga      300

ggaaccaaat tggaaatcac cggcggagga ggctccgggg gaggaggttc cgggggcggg      360

ggttccgaag tgaagctcca ggagtccggc cccggcctgg tggcgccgtc gcaatcactc      420

tctgtgacct gtaccgtgtc gggagtgtcc ctgcctgatt acggcgtgag ctggattcgg      480

cagccgccgc ggaagggcct ggaatggctg ggtgtcatct ggggatccga gactacctac      540

tacaactcgg ccctgaagtc ccgcctgact atcatcaaag acaactcgaa gtcccaggtc      600

tttctgaaga tgaactccct gcaaactgac gacaccgcca tctattactg tgctaagcac      660

tactactacg gtggaagcta tgctatggac tactgggggc aaggcacttc ggtgactgtg      720

tcaagc                                                                 726


<210>  33
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid Sequence of ScFV CD19 (FMC63)

<400>  33

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  34
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of anti-CD33 ScFV (LTG1936)

<400>  34
caggtgcagc tggtgcaatc tggggcagag gtgaaaaagc ccggggagtc tctgaggatc       60

tcctgtaagg gttctggatt cagttttccc acctactgga tcggctgggt gcgccagatg      120

cccgggaaag gcctggagtg gatggggatc atctatcctg gtgactctga taccagatac      180

agcccgtcct tccaaggcca ggtcaccatc tcagccgaca agtccatcag caccgcctac      240

ctgcagtgga gcagcctgaa ggcctcggac accgccatgt attactgtgc gagactagtt      300

ggagatggct acaatacggg ggcttttgat atctggggcc aagggacaat ggtcaccgtc      360

tcttcaggag gtggcgggtc tggtggtggc ggtagcggtg gtggcggatc cgatattgtg      420

atgacccaca ctccactctc tctgtccgtc acccctggac agccggcctc catctcctgc      480

aagtctagtc agagcctcct gcatagtaat ggaaagacct atttgtattg gtacctgcag      540

aagccaggcc agcctccaca gctcctgatc tatggagctt ccaaccggtt ctctggagtg      600

ccagacaggt tcagtggcag cgggtcaggg acagatttca cactgaaaat cagccgggtg      660

gaggctgagg atgttggggt ttattactgc atgcaaagta tacagcttcc tatcaccttc      720

ggccaaggga cacgactgga gattaaa                                          747


<210>  35
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of anti-CD33 ScFV (LTG1936)

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Phe Ser Phe Pro Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Val Gly Asp Gly Tyr Asn Thr Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr His Thr 
    130                 135                 140                 


Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Lys Ser Ser Gln Ser Leu Leu His Ser Asn Gly Lys Thr Tyr Leu Tyr 
                165                 170                 175     


Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile Tyr Gly 
            180                 185                 190         


Ala Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
    210                 215                 220                 


Val Gly Val Tyr Tyr Cys Met Gln Ser Ile Gln Leu Pro Ile Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Arg Leu Glu Ile Lys 
                245                 


<210>  36
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence of anti-mesothelin ScFV (LTG1904)

<400>  36
gaggtccagc tggtacagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct      120

ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat      180

gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat      240

ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaaagattta      300

tcgtcagtgg ctggaccctt taactactgg ggccagggca ccctggtcac cgtctcctca      360

ggaggtggcg ggtctggtgg aggcggtagc ggcggtggcg gatcctcttc tgagctgact      420

caggaccctg ctgtgtctgt ggccttggga cagacagtca ggatcacatg ccaaggagac      480

agcctcagaa gctattatgc aagctggtac cagcagaagc caggacaggc ccctgtactt      540

gtcatctatg gtaaaaacaa ccggccctca gggatcccag accgattctc tggctccagc      600

tcaggaaaca cagcttcctt gaccatcact ggggctcagg cggaggatga ggctgactat      660

tactgtaact cccgggacag cagtggtaac catctggtat tcggcggagg cacccagctg      720

accgtcctcg gt                                                          732


<210>  37
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence of anti-mesothelin ScFV (LTG1904)

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Ser Ser Val Ala Gly Pro Phe Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Ser Ser Glu Leu Thr Gln Asp Pro Ala 
    130                 135                 140                 


Val Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp 
145                 150                 155                 160 


Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln 
                165                 170                 175     


Ala Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile 
            180                 185                 190         


Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Asn Ser 
    210                 215                 220                 


Arg Asp Ser Ser Gly Asn His Leu Val Phe Gly Gly Gly Thr Gln Leu 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  38
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  38
gagtcaaaat acggtcctcc gtgccctccg tgtccg                                 36


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  40
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  40
gagtcaaaat acggtcctcc gtgccctccg tgtccgatct acatttgggc cccgctggcc       60

ggcacttgcg gcgtgctcct gctgtcgctg gtcatcaccc tttactgc                   108


<210>  41
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  41

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ile Tyr Ile Trp 
1               5                   10                  15      


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            20                  25                  30          


Thr Leu Tyr Cys 
        35      


