                         SEQUENCE LISTING

<110>  Hekele, Armin
       Beard, Clayton
       Jantz, Derek
       Smith, James J
       Bartsevich, Victor
 
<120>  ENGINEERED NUCLEASES THAT TARGET HUMAN AND CANINE FACTOR VIII 
       GENES AS A TREATMENT FOR HEMOPHILIA A

<130>  P1090.70027WO00

<150>  US 62/580,031
<151>  2017-11-01

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  1

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Ala Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Trp Arg Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 
            


<210>  2
<211>  9
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  2

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  3
<211>  9512
<212>  DNA
<213>  Homo sapiens

<400>  3
ttgaacagtc actgagcaac tactatgtcc tgggttctaa ttcaggggtg ggcaaactat       60

agccccagaa tttggcccat agcctgcttt tgtacggact gtgagttaag aatagttttt      120

acacgttgaa aggattgcaa agacaaacat acaaagaaac aaagaagact gtgcaacaga      180

gaccacctgt ggtctgtaaa gactaacaca tttctatccc gcccttgaca gaaagagtct      240

gtgggctgct ggtctcctct aacggtggta gagatgcctg cacggttaac attaatcctt      300

ggcaccagaa tcctcagcac ctaggaacca gatcttgcct aacacgctaa tttcagtctt      360

gaccaccttc ctccggcgta gcggttctca aacgtctttg tctttgtact attcacgtat      420

aaaatattct ttcataagca acatttatcc ttttgggaat acctcacaat ggggagaagg      480

ggaaccccaa cagcctttaa gggttcactg cttcgctgcc accatttccg acggtttaca      540

ctgttttaag tgtgaatttg gaattgtttt caagttaaaa agcaaactaa tcatgtcctc      600

tgaaagtatt tgcttttggc atgctagaaa tcagtgttga cttttgatac tgatgtgata      660

cattacgagg gaattctcaa aactgctgaa atctggcctc ggcccagtta tcactgctct      720

taagcttctg agggagatac atgaatgagc ccacggcaaa tggaaaacga ggagttttag      780

tgtttcctag aattatgctc agatacccac tacctgaccg tctggttatc cttcccctca      840

cctccctgac gcaaggagtt tggaccagag gcctaaggag gcttctcctg aagcccaaat      900

cccaaactgg tcaccagtca tgctccgtaa ctcctgaacc tgacaagaag ccagccggcc      960

aggtctgcag cccgggttaa gaggagcata ccaggaaaga gccaaagagc aaaggagcat     1020

gagcccttca accgctttta caataatttg ggctaggcgt tcagggctcc gtaggaccct     1080

tcctggcagc caagtgagag aaagaggaat gatggtggaa tgggcctctc ctgtgcttcc     1140

cattacttcc acactgtcga aatagaaata gaagcagaaa agaacaccct acaagtccca     1200

cccatttgga ggcactcaac tcacagtgac aaccctccac acctctcccc tgcaaaaaga     1260

cgcaaaacaa aaacacctac tccaaactgt gtccttacat ctcagccccg aagatcagga     1320

ttgtgtgcaa cttcggccca aaggatgcat ttccccaggg ttgaaagttt gagaaagagg     1380

ctatattctg aagagttctt gttgtcacca tcaaaaggat taaaaagacg caataaataa     1440

gaaaacagcg tagttggggg gcatgctcca tttgagccag aaagccttgg aaacttaagt     1500

gttctcaaac ggaacgccat cctgctttgg gggaacacgg aggctgcctt gcagtcacgt     1560

gatcgcacaa caccaaaggg ccacgcactc tgatttcacc tacttaacta aaagttgcag     1620

caaaatccct attacaggcc aggcgtggtg gctcatgcct gtaatcccag cactttggga     1680

ggccgaggag ggtggatcat ttgaggtcag gagttggaga ccagcttggc caacatggtg     1740

agaccccatc tctattaaaa atacaaaaat tagcccagcg tggtggtgca cgcctgtaat     1800

cccaggcacc ctggaggttg aggtaggaga atcgcttgaa cccaggaggc ggaggttgca     1860

gtgagccgag atcacgccac tgcgctcctg cctgggcgac agagtgagac tccatctcgg     1920

ggaaaaaaaa aaaaaaaaaa aaaaaaatcc ctattacaaa taaaagctgt tgtgatccag     1980

actgcatata cctctgcgaa tggaaccaga accgtgaatt ccaatgcaaa tcgatgcatc     2040

ggcaccagac ccgctgcact ggatgtatct gcattgcagt cacccgagta cggagcacat     2100

catagatgat ctctgcaggt tcgttgccca cataggaggc atagcgcaaa tttcaaagga     2160

acgaatacat cctggagccc aaacagctat ctggttctgc tgctggcctc ctgacaagta     2220

ggtaagagag tcacatttta tagacgacgg acaccaaaac cacacatgag gagtacaaga     2280

gtagctttat catggattta gggctgtggt tacaaggaag ctgtaaggaa taaaatgact     2340

cccatgaaga cgtaccgtgc ggacgagtgg aaggagaaat ttggccatta caaagacaca     2400

ggaatatgtt aagaagtgag gggcaggatg aaatcatcta gggtaggtat ttagagggag     2460

ggcgccgtgc aaaataaaat cctcactatg aaacaaaggc ggaggcagga ggctgcgtta     2520

ggtggaagca gcggaggaag gagacgaaag ggattgtcat tttcatgtcg tggcttttta     2580

gaagacagcc atgtcctcta ctctgattct atcaaaatgt gttctcgggg tgctggtaac     2640

gttcagccaa cgaaataatt cctatggcgg cagtaggaat aacaaaacgc agaagcggga     2700

acgatgtctt tttattcctc cccagacgca aacgtggatg catgaggttt ggtaacaggc     2760

aaagtcatct ggttaacgtg actgatgcaa aaagtccagg cctgggcaaa aagaagtcac     2820

tgggtgaatg ggatggatca gactccctgt cctgaggggg agatggtttc ttgcagaacg     2880

aggtgaagga ggtggttctg ctcagcagtc aacagtggcc acatctccac ctgcagcgac     2940

ttgatggctt ccgtgtcctt ttcgtgggta gccatgacca aagactggag cagcagaaag     3000

agctcctcgg gaagctggcc gctgctctcc tgcccgtggc tgtcaaaagc ctcccaggag     3060

tacttctcca gggtctgggc gtgctccggc agcagcttgg cgggcggtgg ttgcaggagg     3120

agcagcagca gcacgcggga cacctcgcag cggaccagca cgtccgagaa ggcgcccagg     3180

gcggcgggag agggcgccgc cgagccggag ttcggaggaa gcagcgcggc cggtagggcg     3240

ggcgtcgccc cgggcccggg ctggggtgcc ggcggcgggg gcggcggcag tgactgcacc     3300

gggtggctgc cgtgctcccg cgccaggcgc tgcatgcgcg tgaagaccgc cagggcgccg     3360

gtgtagtcgc gcgccagcag ctggcaggag gcggcctcgc caagcgcctg cagcgcggcc     3420

aggggcagct ggggcagctg gagctgggcg gcgcgctgga agtgaccggc ggcggcggcc     3480

ggctggccca ggtcgcgcag ggcggcggcc agctcgaggc agagggcggc ggcggcggcc     3540

ggctggccca gctcgaggtg cagacgcacc gcggcgccca gggcgctggc ggcggcctgc     3600

agcggctccc cgtaggcggc ggggcagacc aggcgctggc gcgcgtcgcg ctcctgccgc     3660

aggaagaggc gggcggcctc ggtgagggcc agcgcctccc cgggcccgtg gaagagcgcc     3720

tgctggcagc gcgccaccgc cagctggcac caggccgcgt agggcagaca ctcctgggcg     3780

cgcagctccc ggcccagctg tccgaactgc tcgccggcct ccgccacgtt cggcttccgc     3840

aggaaccgct tcttcagctt gttcgatacc agccggtagc gggccaggaa gtccccggcc     3900

tcgggtcccg ggccggcgcc gccgccgccc aggcctgcag ccgctgccgc catgctcgcc     3960

gccccaagca cttcccgacg cgccgccgca gctggcgggc gggccggggc ggggcgacgt     4020

gccctgcgtc cccctcggcg ggctgccgcc gtgcccgcgc cggctcccca gcccgagcct     4080

gccccttgcc ctgatgaggt gcaaagagcg ggatcggagg cggggcctgg ccgggctgtg     4140

agcggcgtat gcaaatcgag ggtctcgggg atgcggatcc aagaccctgg gaaggtacgc     4200

ggggcctggc ggggcaccag ctgctgctag ctcggctgca atgcaagtgg tctaggttgc     4260

taaaggcatc ccacagcctc tccatctgaa catgacccaa acgaaactcg tgaccctaat     4320

tccatgtctg cgcatttcta gactgttgtc cccccccccc cccgccccga ctactcagtc     4380

ctccgtcttc cggtccaggg ccccttgcca agcaccgggt ccacctctcc gtccccaccc     4440

cggttgcctt agaagtccgt cctgtcgcaa cactgcagtc atggtcttga ggcccacccg     4500

ccccaacgaa caccatcatg ctgaggactt tcccgggcag gccctgactt gctcagaacc     4560

agcgggggtg tccccttccc acccagggcc actcccctgc actgtcaccc ggagagactg     4620

ctcctctgtg ccatccctgg ctcccaccca accccagacc cccaccacct ctccatccct     4680

ccagctgtgg aggtctcaca accccccaac ccatctcacc gcccccccac ccccacccca     4740

aggcaaagtg actgaagcgg gcagatggct tccttgaaac attttattga cagaattaat     4800

gaaggcccaa gactttgggg cctgggttgt ggggggaggg tgtttaaggc cgggggttca     4860

ggccggggga tttggggccg ggtgggtgga cgagtggacc tgtcaggtcc caggggccgg     4920

gtgtcagaag ctagtcctcg ccaggggcca cttgagagat ggtggtcgtg ttgaaaaggg     4980

tgctcagtag cctgtcgttg tgaaccacca tgtccagcag caggggagtg atgttccgct     5040

ctccgctgtt ctgggcctcg ttgcccgcca gctccgggac cttggccgtc aggtactcaa     5100

taaccgcagc gaggtagacc ggcgccgtgc gactcaggcg ctgagcgtag tggccctccc     5160

gtagactgcg ctccacctgg ctcactgaaa acgaaagctc cgctcggacg gtgcgagagc     5220

aggtccgccc ccggccgcca gcaccggagg accctcggcg tctcctcctc ctcggcatgc     5280

tgggcgttga gtgtgctatc tcggcttggc ccagctaggc aagatggctc tcaagaggac     5340

agttaccgcg tccagtactg tgtatcctag cgaccagggc ccagcccctc attggctagg     5400

gagccgagac caatgggcac gcacatccgg cgacgggcac gcatgtggtg acggcccctc     5460

acaagggaca cacgtccgtc aggtgacctc atcactttcc cattggcctc gagggagcag     5520

gcctgggcct agaagtggct ggagggccgt gggggtgggg tggggcgggg cagggggaat     5580

cgcgctggtg accctctctt tgccagtggg aactttccct ttctactgga tgggaacacc     5640

gtgggaaaga caaaggggtg ggcgagggga ggacgggtac cacgccttca caatgttgca     5700

catccatcac gaccacctag ttccaaaacg ttttcaacac cccgaaaaga aaccgaaacc     5760

cctgtaccta taagcagtca cttgccgcac gcctccttcc acaccaccac taccagcccc     5820

cacaccctcc cacacacacc ccctgccccc gcccatacac acgttcccga tagtccctga     5880

caacccctag tccatctgct ttctgtccat agaggttagc ctgttctgga gatttcctat     5940

agatggaatt atacgaccaa atgtgaggcc gtgtgtgtct ggctgctttc acttagcgta     6000

atggtttcat cagggtgcat ccatgtagag gcatgaatca ctacttcctt cctttgaatg     6060

actgagtacg attctgttgt atgaatagga ggccacattt tgtttaccca ctcgtcagtt     6120

gatggacagg ttatttcccc cttctggcta ttgtgagtgg cactgccatg accatctctc     6180

tacaggtttt tctttgaata tctcttttca gttcttttgg gtctatttct agcagtcaaa     6240

ctgctggctc gtgtggtaat tctgtttaac ttattgagga accaccaaac tgatttccac     6300

agcagctgta atctttcgca ttcccaacag tagtgcatga gagtcccaat ttcttcacag     6360

cctcatcaaa acctgttttc tgtttgcctc attttgtttt gtttacagta gccatcctac     6420

tgggtgtcaa gtgctatctc atggtggttt tcattcgtat ttcccaaatg gctaatgatg     6480

ttgctgtggt ttgagtgcat cccccaaatt gtgtgtcttg gaaacttaat ccccaaattc     6540

acatgttgat tggaggcgca gcctctgaga cggtaattag gattagataa ggtcatcggg     6600

gtgagacccc caggatgcga ctggtggctt tataagaata ggaagagagg cctgaaacga     6660

catacacgct cttgccctct cgccgtgtga taccctctgc cgtccccaga tgccgggtca     6720

cttcccagtc cccagaacgg taagaaataa atttcttttc tttataaatt gttcagtgtc     6780

gggtattcaa ttatggcaac agaaaacaga ctaagacatc ttttcatgtg cttcttggcc     6840

ctctgtacct ctgctttgga ggaatgtcta ttcaagccct ttgcccattt tttaattcgg     6900

ttgattgtat tttggctgtg ggcttctaaa acttattcat atattctgga aaatagactc     6960

ttatcagata tgtgacttgc aaatgtttct cccattcact ttctggatag agccctttgt     7020

tgcccaaaag atttacattt ggatgtagtc caacttgcca aatgaaaaga tatctgtggc     7080

tttgcctttg gtgtcatact gaaggagctg ttgcctaatc caaggtcgtg caaagttaca     7140

tctccgtttt cttcttagag ttttatagtt tcagccctta catttagatc tgtgatccat     7200

tttgaattaa ttctttacat gatgtgaggt aggggtccag gggccttctt ttgcatgtgg     7260

ctatccagtt gtcccagcgc agtttgttga ggggattatt cttcccctcc acccattgag     7320

gggtgccgga actcttactg aaaataaact ttacataaat atatgggttt attcctgact     7380

ctgagttctg taacattgac ctaatgtatc gatcacgatg gcagtaccac ccttttcgga     7440

ttactgcggt tttgtagtac gttttgaaat tgggaagtgt gagtccttca acttttttct     7500

tttctgagat tgttttggct atctgagccc cttacatttt cttatgaatt ttaggatcag     7560

cttgtcagtt tttacaaaga aggcaggttg gattctgaca ggcatcacga tgaatctgta     7620

tattgccttg gagattatgg gcatcttaac aatattaagt gtcccaatcc gttaacacaa     7680

aatgcctttc gatttattta ggtcttcttt aatttatttt agcaacgtct tgaaattttc     7740

agagtataca tcttgtacac ctttagttaa atttattcct cgacatttta ttgtttcgat     7800

gctactgtaa aatgaatcat ttccttaatc ttattttcat gttattcatt gctagggtgt     7860

agaaatacaa ccgactgttg cagattgatc ttggatactg caactttgct gagccgaata     7920

tgctttgctg agcatactca gacagggttg gcatattagt ccgttcctac actgctataa     7980

agaactgcct gagaatgggt aattcctaaa gaaaagaggt ttaattgcct catggttctg     8040

caggctgtac aaggcttctg cttctgggca ggcctcagga aacgtgcaat catggcggaa     8100

ggcgaagggg aagcaagcac cttcttcaca tgttggagca ggaggaagag agagagaacg     8160

cacgcaaagg gggaagcgct gcacattttc aaacaatcat cagatcttgt gagcgctcta     8220

tcagaagaat agcaaggggg aagtccgccc ccatgattca atcacctccc actaggccct     8280

tccttcaaca ggtggggatt acaattcgac atgagatttg ggtggggaca cagagccaaa     8340

ccgtctcagt tttttttttt ttcttttgtt ggactcttta gtgtcctcta tataagaaca     8400

tgccatctat gcatctatga atagagatgg ttttacttgt tcctttccga tctggatgcc     8460

ttttatttct ttttcttgac taattgccct gactagaact ttgagtacga tgttgagtta     8520

caagtggcat tcctgatctt agggggaaat caaccagtct ttcaccatta agtatgatat     8580

tatctctggg tttttcatgg atgccctcta tcaggttgaa gaagtttctt tctgttcctg     8640

gtttgttgaa tttattttca tgaaagggta ctgcgttttg tcaaatgatc ctttttgtac     8700

atgattaaga tgaccatgag ccccctcccc cgcccccgct ccgccatgca ttctgttaat     8760

atggtgtatt atataaattg attttcacat gttgaaccaa ccttacattt gtgggataaa     8820

tcctatttgg tcatagtgta taaagagtgg tcaataaaca tttcgttgaa agaataggag     8880

tggatctggc aagcttcttg gaggacaatg tgtgtgttaa agaatctgta gcatgatgag     8940

aagccaaggc accggtggga ggaggggagt tgcaaccaat tcattaaggc tggagagtac     9000

gatgccagtg gagcagtagt ggttgatgtg gctgggaaag aggtaggcag gagccaagac     9060

atggaggttc tattatgcca tgctcaggtt ttagaatacc ctgtaggcta cactgaaccc     9120

actgtggtct ttcagcttgg gagtgacgtg gtctgatttg cctctagaaa tatcaccctg     9180

gaagctgtgt ggagaataga acagagagga ttgtgtgtgg agaatagaac agagaggact     9240

gagattggaa ttagaaagct gctgtattat accagtcaag aaatgacaga tatctcaact     9300

aagacaatgg cattggtaga taagactagg ggacagagtc cataaaaagt ttaggtagta     9360

aaatggcaca cagtagacac tcactacata ttactcatac tggcgaacct agctggagac     9420

atgataattc atgtgctcat tcttcaaaaa atattgaagg gtagtgccag gtatactgtg     9480

ttaagcattg agacaacacc aacgagaaat at                                   9512


<210>  4
<211>  13008
<212>  DNA
<213>  Canis lupus familiaris

<400>  4
aagattttat ttttatttat ttgaaagaga gcatgagggg atccctgggt ggctcagcgg       60

tttagcgcct gcctttggcc cagggcgtga tcctggagac ccgggatcga gtcccacatc      120

aggctccttg catggagctt gcttctccct ctgcctgtgt ctccacctct ctctgtgtgt      180

ttctcatgaa taaataaata aattttcaaa agagagagag agcatgagta agagggagag      240

ggagagatag agaatctaaa gcagactctg tgctgagcag gaacccaaca cagggctcaa      300

tcccacgacc ctgagatcgt gacctgagcc aaaaacaaga gtcagatgct taaccaactg      360

agccacccag gcgcccctgg agttgttttc taactcatta atttctgttc aaaactttaa      420

aattttcttt tactttcttt cggttttgtc tttcctaaaa catggagttg aatgactagt      480

tcatttattt tcagtctttc tcattcagta tgataaaaga gttaactact ctcatgaagg      540

tcattcattt aataaacagt tactgagtaa ctgctatgtt ctagattcta gtacagagat      600

ggggaagcta gagcccatcc ttgaatttgg actaccactt gcttttgtac ggactgtgac      660

ttaagaatgg tttttacagg tttaaagttg caaaaacaaa cattatgcaa cgaagatcat      720

ttgtggcctg aaaagactaa aatattgcca tctggtcctt tacagaaagt ttgcagactg      780

ctggtctggc ctaaaggcag tagagatgcc taggcagtgc catgaagcag gactcttcat      840

ccccacagct tgcctaatgt gcagatttca atcttagtca tcgtccccca gtgtagtgat      900

tctcagatgt ttttatatct ttgttttgct cacagacaaa atcttgttca tcagagatat      960

ttcttatcat ggatgtccca cataaagagg gagaggggaa cctttaagga ccacagctac     1020

actgccaccg ttctcaatag tgtagaataa tgtaaatgtt aactttttta tttttttaag     1080

atttatttat tcacgaaaga cacagagaga gaggcacaga cagaggcaga gggagaagca     1140

ggctccatgc agggagcccg acatgggact ccatcctggg gccccagcat cacgccctgg     1200

actaaaggcg gcgctaaacc gctgagccac ctgggctgcc ctaacttttt tattttttaa     1260

aagattttac ttatttatcc atgagagaca cagagaggca gagacacagg cagagggagg     1320

agcaggcttc atgcagtgag cccgatgcgg gactcgatcc caggacccca ggatcatgac     1380

ctgagccaaa ggcagatgct cagccactga gccacccagg tgcccctgta tatgttaact     1440

ttgatatatc aatgaacatt tcagtgatgt ggctttttct ctctggtttt caagttaaaa     1500

agaagagtat ttttaatgtc ctttaaaaat atttattttt ggttgtgtta gaaatcagtg     1560

ttattttgac ataaagttga taattaccaa gggatttgtc aaagcctatg aaaattgcag     1620

aaatctagcc ttagcccagc tatctatgct ttgaagtttc tgagggagag ctataaagga     1680

gccaatgaca aatggaaaac aactttcatg ttttctaaaa ttatacttgt atacccaaca     1740

ccaggctctc tggcaaaccc tcccctctac atcctcaatg caaggagtta gaccagaggt     1800

ccaagggtgc ttttccttaa gcccaaaccc aaatactgcc accagtcaca tatcaaaact     1860

cctatacatt gttgttgtag tgatgtgatt tgaagtgagg tttgggagcc aatggcgaag     1920

aattcttgag actttttcag tgcaaaaaat gctgttttaa ttacagcaca gggacaggac     1980

ccatgggcag aaagacctgc actggggttg cgaggagtgg ctgattatgt aagattttcc     2040

atcctatgga ggggagggtg atgttaaggt cccaggaaat tgagtatagg gttcgggagg     2100

tctggctatt gatgattgct ttttttcctt gtaaatcatt aagacagttg caaactgatg     2160

gaagattcat gtcgtgcatg actgtgatct ctgtcagtta agcatttgtt tttccccttc     2220

ctttgctctt gggcagccag gagtgcctgc acaacatcac acctttccca cctggtgggt     2280

ggggtgggag gggggcagtt gttgcggagt attagcgtgt gctttaccct cagcttgcct     2340

tttgctccct catcaataag actactggcc agactgaggg gggcacttga cgggatgagc     2400

actgggtgtt actctagatg ttggcaaatt gaacaccaat aaaaaataaa tgtataaaaa     2460

aaaaaaagac tactggccag gcctgtagcc cgggttgaga gtataccaag aaaagtaaaa     2520

ctgcaaagga ccatgcaccc taaccacttt tttaaaaaat gtttttcaaa aattccagta     2580

taattaatgt agtgttacat tagtttcagg tgtacaacat ggtgactcaa cacctctata     2640

catttcccag ggctcatgat gattacgtgc actcttaatc cccatcatgt atttcaccca     2700

tccccacacc tacaccccat ctggtgacca tcagtttctg gtctatattt aggagtctgg     2760

tttttttatc tctttttttt ctttcatctt ttgtttctta aattccacag gagtgaaatc     2820

atacagtatt tgtctttctc tgacttattt cacataacat tatacattct agatccatcc     2880

atgttgcaaa tggcaagatt gaattctttt tcagggctca aaaatactcc attttggatc     2940

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tcttgatcct ttcatctatg     3000

gacacttgga ttgcttccat atattgactg ttgtaaataa tgctgctgta aacatagggg     3060

tgtgtatctt tcttcgaatt agtgttctca ttttcgttgg gtaaataccc agttggggaa     3120

ttacatggtc atatggtggt tctattttta atttttaaag gaacctccat actattttcc     3180

acagtggccg caacagctgg cattcacacc aatagtgcat gaaggctcct ttttctccac     3240

atcctcacca acacctgtgc tttcctgtgg ttttgatttt agccattctg acagatgtga     3300

tatctcattg tggttttcac ttgcatttcc ctgatgatta gtgatgttga gcatcttttc     3360

atgtgtctga taccctaaca cttttgcaat aagttagact aggcttttag ggctccgaaa     3420

gacccttcca ggcagccacg tgagtgcgca ggactggtgg cggagtctgt gtcagatggg     3480

cctcttttgt attttcttac ctactgactg cttccccgtt gctgaaatgg cggcatgagg     3540

actacctaac cgtcccaccc atttacaggc gcttaactca cggtgaccac cgcctacaca     3600

tcccccaaca cacacacaca ctaaaggcaa aacagaactg cccaaccgca tccttaaacc     3660

tcaccccacc agatcagttc cgtacacagc ctcaggctaa agggtgcatt ttccgaaagc     3720

agaaggactg agagggagat tacattctgg agagttctca ctggccctcc caaaccccta     3780

aaggcaagtg gaatgtaaaa acacgcggct agtaacgttt gcacgcgaca tttggaccaa     3840

aaagccttga aaatgtagga ttctgaaaca ggatgctgtc ctcttgggca agaaaggcgc     3900

ggtctcgcag accgaggacc acgcaatagg tcggaagcac gctgattcaa cacatctgag     3960

ttacctacca gtggcgggaa ggcgcccagg acaagtaagt cccagcgtgg cccaggccca     4020

cgtctgagaa tggaacctag gcccacaacc ctgagttcca aggcacgcca gacacctcga     4080

cagtcgaacg tgggcccctg ctttgcgcag gacacattcg ccttggcgcc gaggaaggcc     4140

cacgcggcca aggttgtctg tggattgact gtgcggcaca gcccgagcag caggcgcacg     4200

gaccgctgcg agtgaacgac cacactgcgg cccgaagcac agccacccgc tcttcccctt     4260

gctgcctccc gacaggtgga gcagctattc cgcgttacgg aggaaggcga accgcaggcg     4320

agaggcatca gaacggcttt attgtggatt tagggcagca gccccgaggg cccgtgccat     4380

ctagtgctcc ccaggggtac gcgtggggcg tgggcaacaa aggagaacct gggtgagcac     4440

ctggagagac accggcctgc gctaaagcag atccccgacg aacaaaaaac ggaaccgaga     4500

ggcgtgtgca acatccaacc gtccgacttg caacagaggt gtacgggagg gtgggggtgg     4560

gggtgggggt gggggcccgc aggggagttg ggtgcaagaa gaggccaggg gtaaaggggc     4620

cgctcggtgt cccgtggccc gtcttgggga agagagccaa gtcctccagg ctgaccccgt     4680

gatgctgggg tggttgccgc gccagggacg gcacgaagcc tgtgggatgc gggaggctgc     4740

agtcccgcag cgtccggtgg aggcgggcgg gcgaagagca agacaggtgc gagtgccggg     4800

cccctgcccg tcggtccgtg ggcaccgccg cccgccggcc ggccggccgg ccggccggcc     4860

ggcccgcggt ccaacggcgg ggcagcagca ggccacgggg ccagaggcgg aaagcggctt     4920

cggggctggc gcgcgcgagt ggtcagacgc cctgccccga cggggacacg gcttcctgca     4980

gaacgaggtg cagcaggtgg ttctgctccg cactgagcag cggccacatg tccacctgca     5040

gcgacttgac ggcctccgtg tccttctcgt gggtggccat gaccagggac tggagcagca     5100

ggaacagctc gtcgggaagc tggccggcgc cgtcgggccc gtggccgtcg aaggcctccc     5160

aggagtactt ctccagcgtg tgggcgtgct cgggcagcag cttggcgggc ggcggctgca     5220

gcaggagcag cagcagcacg cgggacacct cgcagcggac cagcacgtcc gagaaggcgc     5280

ccagcgtggc gggcgcgggc gtgggcgtgg gcgcgggcgc ggcaggcagc agggcggcgg     5340

gcagggccgg ggcggcggcg gcggggccca gcggggcgga ggccgacgag gacgaggccg     5400

aggccgacga ggtcgaggcc gaggccgacg aggtcgacgc cgccgccggc ggggccaggg     5460

gcagcggcgg ggcgggcggc ggcggggccg ggggcggctg ccgcagcggg tggctgccgt     5520

gctcccgcgc caggcgctgc atgcgcgtga agacggccag ggcgccgctg tagtcgcgcg     5580

ccagcagctg gcaggaggcg gcgtcgccca gcgcctgcag cgcggccagg ggcagctgcg     5640

gcaggtgcag ctgcgcggcg cgcaggaagt ggccggcggc ggcggccggc tggcccaggt     5700

cgcgcagggc ggcggccagc tcgaggcaca ggccggcggc ggcggccggc tggcccagct     5760

ccaggtgcag gcgcacggcg gcgcccagcg cgctggcggc ggcctgcagc ggctccccgt     5820

aggccgcggg gcaggcgagg cgctggcggg cgtcgcgctc ctgccgcagg aagaggcgcg     5880

cggcctcggt cagcgccagc gcctccccgg gcccgtggaa cagcgcctgc tggcagcgcg     5940

ccacggccag ctggcaccac gcggcgtacg gcaggcactc ctgcgcgcgc agctcccggc     6000

ccagctgcgc gaactgctcg cccgcctccg ccacgttcgg cttccgcagg aaccgcttac     6060

gcagcttgct cgacacctgc cggtagcggg ccaggaagtc cccggcctcg ggccccgggc     6120

ccgcgccgcc gccgccgccg ccgccgccgc cgcccgggcc gccgccgccg ccgccgcccg     6180

ggccgcccgc cgccgccgcc gccatcttgc ccgcacgcgc gcacgcccga cgtgcccgcg     6240

tcccccggcc ccgccccctg cgggccccgc ccccccgcgg accccgcgca tgcgtgcgcc     6300

gccccccgcc gtcccgccgg acggaaccga gcgcgcgggc cggcgcgggg cctgggcggc     6360

cgcggccctt ccgaggcgac cccggccccc gggtcggccc gcgccccccg gcccctcccg     6420

gcccctgccg gcccccgagc taacgtcgcg gcgccggccc gcctggcccc gaggccgctt     6480

ggccggagtc aggatggtcc ccgccccccc agccttccgt caaagccctg tcccctcgag     6540

tccgcgccgg cacctgtgtc ccccaacagt ccgcgccggc agctgtgtcc ccccattcac     6600

tccgcgccgg caggtgtgtc cccctccatc ccgcagccag gttgttactg caccggcgtt     6660

caccccatca ccacgccgca ggcatggtcc tgagctccag ccccacacac accatcgtcc     6720

acgggactgg cccgtgcggt gggggggggt cttctatgcc ccagcgtcac tcccagccca     6780

gccaccccct gtcctgaccc cgagcagtcc ccgtccccgc accccagccg gaccccacca     6840

ccacccctgc accccagccg gaccccgcca cagcccccgt ccctgcaccc caacaatgct     6900

ccggaccgca tgaccgaacc ccgcaccaca cccacgaacc cgcgccccac gccacacccc     6960

aaatcctcca tcacccccat cgtgcaccgc cgagggcacc ccaacccccc gtcatccccg     7020

agccccgcac ccccacccca acctcgccca caaccccaaa ccccaacctc ccccccgccc     7080

ccccccgccc tccccccgag gcgcgtcccg cacccagtga gccaggcgca cacgtctggt     7140

tgtctctgcg ccttttattg cggggacgcg ggggtcaccg agcccccccg gcggctcccc     7200

gggcggcggc gggcatcagg ggccgggggc ggctagtacc gggccggggc cacctgggac     7260

acggtggtca tcgtgaacaa gccgctgagc agctcgtggt tgtgcagcgc ccggtccacg     7320

agctccgggg tgatgtacgc ggtgcgcctg tgccgggcct cgtcgcccgc cagccccagc     7380

acggtggccg tcaggaactg gatgacggcc gccaggaaga tgggggcgga cgcgcccagg     7440

cgcttggcgt agcggccggc ccgcaggagg cgctccatct ggcacacgga gaaggccagc     7500

cccgcgcggg cgctgcgcga gcggcacgac ctcgggcggc cggcccgccc tccacggctc     7560

cccctgagcc gcgcgcgggg cctcggcggc gctcggcgcg gggcctcggg ctgcggcccg     7620

gctgcggccc ggctggggac gctcgggcgt cgggccgcgg agccacgggc ctcgggctgc     7680

ggagaccccg ggctgcggac gctcgggcgt cgggccgcgg agccacgggc ctcgggctgc     7740

ggagaccccg ggctgcggac ggtcgggcgt cgggccgcgg ggacatgggg cttgggctgc     7800

agagacatcg ggctgcggac agagagacac cggcctcggg ctgcggagag acggggcaag     7860

ggctgcagac agacgggcct caggctgcag agagaccgac ctcgggctgc agagagaccg     7920

aactcgggct gcagagtgtc tgacctcggg ctgcagagac cgacctcggg ctgcggagag     7980

acgggcctcg ggctgcagaa agtccgacct cgggctgcag agaccgacct caggctgcgg     8040

agagacgggc ctcgcgctgc agagagaccg acctcgggct gtagagagac tgacctcggg     8100

ctgcagagac cgacctcggg ctgcagagag tccgacctcg ggctgcagag agtccgacct     8160

cgggctgcag agagacgggc ctcgggctgc gctgccgaaa cagcgtcggg gcgcagagag     8220

gagcgccggg gtgcaccgcc gtgcggcgcg ctgggccggc tgcacccgag ccctcagcag     8280

cgggcgagga ggccccgctc cgtatccgag ggacacaccc cctccccgcc ccgctgcgca     8340

cgcggtgaca cgcaggcctg atgaggtcac cgcgtcccca ttggcccggc ccggccctcg     8400

cccgccagaa aagccgctgg cgggaagtcg ctggctctgc gccgcgcgga cggcatgggg     8460

cgccaccgac gagcgtgcag gagctcgcgc gcccccacgt gcacccccga catgtcggcc     8520

ctctcggctg cacacgcggc accgccccgc acagacggcc cggccgccgc gcgctcactg     8580

ccccctgcac cccgtcctgc ccccggggac cgaccgctcc tcggcctcct gtccctgccg     8640

cttggcgtcc gctggacacc tgctgcaggg gccaccctgg gaccagtagg tggccgtgtg     8700

cgccggccgc gttccctcgg caccgtgttc tcaggagggc tgttctctga gggagcggga     8760

accggggtcc ctccccccga gagagcagga atcgggcccc tccccctgag ggagcaggaa     8820

tcggggcacc cccccccagg gagcaggaat aacggcctct tccccccccc cagggagcag     8880

gaatcggggc ccctcccctc aagggagcag gagtcggggt ccctcccccc cgagagagca     8940

ggaatcgggc ccctccccct gagggagcag gaatcggggt ccctcctccc gagggagcag     9000

gaatcggggc accccccccc ccagggagca ggaataacgg cctcttcccc cccccccccc     9060

cgggagcagg aatcggggcc cctcccctcg agggagcagg aatccgggac ccccaaggga     9120

gcgggaattg gggtccctcc gcccgaggga gcaaaagacg gacctcgggc tgcagaaaga     9180

cggacctcgg gctgcggaga gaccgacctc gggctgcgga gagaccaacc tcgggctgcg     9240

cttccgaaag acggcgtcgg ggcgcagaga ggagcgccgg ggtgcaccgc cgtgcggcgc     9300

gctgggccgg ctgctcccga gctctgagca gcgggcgagg aggccccgct ccgtataaaa     9360

gcgacacccc ctcccctccc cgctgcgcac gcggtgacac gcagatctga tgaggtcacc     9420

gcgtcctcat tggcccggcc ctcgcccgcc agaaaaggcg ggaagtcgct ggctctgcgc     9480

cgcgcggacg gcatggggcg ccacccacga gcgtgcagga gctcgcgcgc ccccacgtgc     9540

acccccgaca tgtcggccct ctcggctgca cacgcggcag cgccccgcac agacggcccg     9600

gccgccgcgc gctcactgcc ccctgcaccc cgtcctgccc ccggggaccg accgctcctc     9660

ggcctcctgt ccctgccgct tggcgtccgc tggacacctg ctgcaggggc caccctggga     9720

ccagtaggtg gccgtgtgcg ccggccgcgt tccctcggca ccgtgttctc aggagggctg     9780

ttctccgagg gagcgggaac ccgggtcccc ccccccaagg gagcaggaat tggggtccct     9840

ccccccgagc gatcaggaag cggggtccct ccaccaaggg acaggagtcg gggtccctcc     9900

ccccgaggga tcaggaatcg gggtccctcc accaagggat caggagttgg ggtccctccc     9960

ccaagggaca ggagtcaggg tccctccccc aagggacagg agtcggggtc cctccgccaa    10020

gggacaggag tcggggtccg tccccccgag ggagcaggaa taggcccccc gaggcagcgg    10080

ggatcgccct gcacgtccat cgaggggcac tcgcccccac tgcgcgcccc ccctggcggc    10140

gaggggcacc tgcgggcgga cgtgcgcggc ggcggcggcg gcgaaggtcg cgcggggccc    10200

ctccgggcgc gggatggggg gcccgacggc agggcgacac ccgctgtctg ggcagcgcgc    10260

tgacccggcc ccctgctccc gccgcgccgc cccactggcc ctggcccgcg cctgctcctc    10320

ccggtgcggc ctcgcgagcc cccgcgccgg ctgtgccgcg gcacctggca cctgggggtc    10380

actgtccccc gtgtgtaggg aggggcaggg cggggcccga gggacaggga gctcgggcag    10440

ctgcagcccg ctgacccggg cccccgtgga gcctgcgggc tccccccgcg cccccagggc    10500

tgccgacccg agcccgggct gcaggcgggc gcccagctga tcccccccgc cccccccccc    10560

cccgggctgg gcctgtcgcg cccccgggtc ccgagcgccg ccccgcggtg ccagcagcgg    10620

cgggtcggcg cggcgggagc gctgcaggtg cgccgggacc gggcggggcc ctccctctgg    10680

gtgcccctcc aggcggcccc tgcactcggg ctgcgcaggg cggggcgggg gagcttcccg    10740

gagggggtgc ggcctgtctg tcgcctgggc gcgactcggc gatgggacac gttcaggtcc    10800

tgacaccggg gggggggggg ggagcggggg ggcttcccgc gtattcgggg cctcccgagt    10860

gactttcagc aatgttccgt gactttccgt gcacacgccc tgcacgtcct ccgctacgtg    10920

tattcctagg gatgtaattg cacgtgatcc cgatttgaat aaaattattc aatcagttag    10980

ttaactgatc aattaatcag tttcgtttga ggttcgtcgc cgctgccgcg tggaaaaccc    11040

cctaatttct gcacgttggt ctcatatcct gaagtttgtt gaattcacta actctgccgg    11100

tgtttcgtga attctttagg actttttctg tgtaaggtta tgtcatctga gaacacagat    11160

ggttttcctt cttcctttcc aatttaaata ccctttattt ctttctcttg catcattgct    11220

ctagccagga tttccattac aatgtcggtt agaggcaggg aaagcgcgga ttcttgttcc    11280

tgattagggg aaaagctttc agtcctccac cagtgagtat gaccttagct atgggtattt    11340

cataaatgcc ctttattatg tttggtgatt ccccttctat tcctagtttg ctgagtgttt    11400

tttgtcagga aaaggtggat tttagtcaat gctttttctg catgaatcaa gacagtcatg    11460

tgggtttttc cccctttatt ttattaacgt agagttattt tcttaagttg aagcatcttt    11520

gtattcctgg gacagttcct ttttggacat gaaatgtcac ttttataatg tactgctgga    11580

ttccgtctgc taaaatcatt tgaggatttc tgcacctata ttctttttta aagatttttt    11640

aggtactatt tgagagacca tgaatgatca gggggcggag ggagaggatg aagcagactc    11700

cccactgagc agggagcctg acgcgggcct cgatctcccg acccgggatc atgacctgag    11760

ctgaaagcgg atgcttcacc gactgagcca ccaggcaccc gggcaaaaca atttcttaca    11820

acattctgca cgatactgta atgctgatgt gtcatcatat aacacacact gattcctatt    11880

ctagtgtatt caagcataca caaagcctag gagatcattt taaactttcc gtagcctgta    11940

cgccatggtt taaaccgagg ccttctgagt aggtgttcct tttttattta aagattttat    12000

ttatttattc atgagagaca cagagagaga gagagaggca gagacccagg cagagggaga    12060

agcaggctcc atgcagggag cccgacgcgg ggctcgatcc caggtctcca ggttcatgcc    12120

ctgggccgaa ggcaggtgcc aagccactga gccccccagg gatcccctga ctaggtgttc    12180

ctatcacatt tctcaaactg tgttcccttt cctttgaaga tgccgtgtac tttctctgca    12240

ccctagactg ctcaaggtcc gaacccccac atgttggatg ttaacacgtg tcttacaaat    12300

ccatacacaa ggaatcatta attaaagcct cacagttcat gcacatgtgc acacacacac    12360

acacacagag agagaccaca gtcttggaag attatcctga ggccagggtg gtagggtggt    12420

gcctgccagc accctctcag atgtggaaca gggcccgaca tacaggactt ctagctacga    12480

cggttgtatg tgagcgctgc gtgctgtcga gagaagcaca aagcaaaatt agagggaaga    12540

tgcaatgggg agcaattgct ttgtaccctg tctgcacctg gcatgtacct gtgctaatcc    12600

ctccccacag gtcttctttg gcaacgtgga ttcatctggg atcaaacaca atatttttaa    12660

ccctccgatt attgctcagt acatccgttt gcacccaacc cattacagca tccgcagcac    12720

tcttcgcatg gagctcttgg gctgtgactt caacagtaag tgcccagtca tcacgtgccc    12780

ttccgtgtcc cagccccggg tgggatgaat gactgtccta gtcttctcga gggcagggcg    12840

atgtcccagg acacagaacc acgaatgcta agagcagcgc agtcccgagc aaacgcaggc    12900

cttggtcatt gtaaccatgg gattccctag gggcagccac ctcctccggc actcttaagg    12960

tcaaagtgcc cccgaactga gaagagctga ccagaaggcg cggggcag                 13008


<210>  5
<211>  1116
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcggcag cggctgcagg cctgggcggc ggcggcgccg gcccgggacc cgaggccggg       60

gacttcctgg cccgctaccg gctggtatcg aacaagctga agaagcggtt cctgcggaag      120

ccgaacgtgg cggaggccgg cgagcagttc ggacagctgg gccgggagct gcgcgcccag      180

gagtgtctgc cctacgcggc ctggtgccag ctggcggtgg cgcgctgcca gcaggcgctc      240

ttccacgggc ccggggaggc gctggccctc accgaggccg cccgcctctt cctgcggcag      300

gagcgcgacg cgcgccagcg cctggtctgc cccgccgcct acggggagcc gctgcaggcc      360

gccgccagcg ccctgggcgc cgcggtgcgt ctgcacctcg agctgggcca gccggccgcc      420

gccgccgccc tctgcctcga gctggccgcc gccctgcgcg acctgggcca gccggccgcc      480

gccgccggtc acttccagcg cgccgcccag ctccagctgc cccagctgcc cctggccgcg      540

ctgcaggcgc ttggcgaggc cgcctcctgc cagctgctgg cgcgcgacta caccggcgcc      600

ctggcggtct tcacgcgcat gcagcgcctg gcgcgggagc acggcagcca cccggtgcag      660

tcactgccgc cgcccccgcc gccggcaccc cagcccgggc ccggggcgac gcccgcccta      720

ccggccgcgc tgcttcctcc gaactccggc tcggcggcgc cctctcccgc cgccctgggc      780

gccttctcgg acgtgctggt ccgctgcgag gtgtcccgcg tgctgctgct gctcctcctg      840

caaccaccgc ccgccaagct gctgccggag cacgcccaga ccctggagaa gtactcctgg      900

gaggcttttg acagccacgg gcaggagagc agcggccagc ttcccgagga gctctttctg      960

ctgctccagt ctttggtcat ggctacccac gaaaaggaca cggaagccat caagtcgctg     1020

caggtggaga tgtggccact gttgactgct gagcagaacc acctccttca cctcgttctg     1080

caagaaacca tctccccctc aggacaggga gtctga                               1116


<210>  6
<211>  1349
<212>  DNA
<213>  Canis lupus familiaris

<400>  6
atgcgcgggg tccgcggggg ggcggggccc gcagggggcg gggccggggg acgcgggcac       60

gtcgggcgtg cgcgcgtgcg ggcaagatgg cggcggcggc ggcgggcggc ccgggcggcg      120

gcggcggcgg cggcccgggc ggcggcggcg gcggcggcgg cggcggcgcg ggcccggggc      180

ccgaggccgg ggacttcctg gcccgctacc ggcaggtgtc gagcaagctg cgtaagcggt      240

tcctgcggaa gccgaacgtg gcggaggcgg gcgagcagtt cgcgcagctg ggccgggagc      300

tgcgcgcgca ggagtgcctg ccgtacgccg cgtggtgcca gctggccgtg gcgcgctgcc      360

agcaggcgct gttccacggg cccggggagg cgctggcgct gaccgaggcc gcgcgcctct      420

tcctgcggca ggagcgcgac gcccgccagc gcctcgcctg ccccgcggcc tacggggagc      480

cgctgcaggc cgccgccagc gcgctgggcg ccgccgtgcg cctgcacctg gagctgggcc      540

agccggccgc cgccgccggc ctgtgcctcg agctggccgc cgccctgcgc gacctgggcc      600

agccggccgc cgccgccggc cacttcctgc gcgccgcgca gctgcacctg ccgcagctgc      660

ccctggccgc gctgcaggcg ctgggcgacg ccgcctcctg ccagctgctg gcgcgcgact      720

acagcggcgc cctggccgtc ttcacgcgca tgcagcgcct ggcgcgggag cacggcagcc      780

acccgctgcg gcagccgccc ccggccccgc cgccgcccgc cccgccgctg cccctggccc      840

cgccggcggc ggcgtcgacc tcgtcggcct cggcctcgac ctcgtcggcc tcggcctcgt      900

cctcgtcggc ctccgccccg ctgggccccg ccgccgccgc cccggccctg cccgccgccc      960

tgctgcctgc cgcgcccgcg cccacgccca cgcccgcgcc cgccacgctg ggcgccttct     1020

cggacgtgct ggtccgctgc gaggtgtccc gcgtgctgct gctgctcctg ctgcagccgc     1080

cgcccgccaa gctgctgccc gagcacgccc acacgctgga gaagtactcc tgggaggcct     1140

tcgacggcca cgggcccgac ggcgccggcc agcttcccga cgagctgttc ctgctgctcc     1200

agtccctggt catggccacc cacgagaagg acacggaggc cgtcaagtcg ctgcaggtgg     1260

acatgtggcc gctgctcagt gcggagcaga accacctgct gcacctcgtt ctgcaggaag     1320

ccgtgtcccc gtcggggcag ggcgtctga                                       1349


<210>  7
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n = c or g

<400>  7
ctcccaggag tacttctcca gn                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n = c or g

<400>  8
gagggtcctc atgaagaggt cn                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  9
ctcccaggag tacttctcca gg                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
gagggtcctc atgaagaggt cc                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Canis lupus familiaris

<400>  11
ctcccaggag tacttctcca gc                                                22


<210>  12
<211>  22
<212>  DNA
<213>  Canis lupus familiaris

<400>  12
gagggtcctc atgaagaggt cg                                                22


<210>  13
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  13

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro His Gln Ser 
            20                  25                  30          


Val Lys Phe Lys His Glu Leu Arg Leu Gly Phe Ser Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ala Asp Gly Ser Ile Tyr Ala Ala Ile Gln Pro Glu Gln Ser Ser 
    210                 215                 220                 


Lys Phe Lys His Thr Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ala Gly Ser Val Ser His Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  14
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  14

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro Arg Gln Asp 
            20                  25                  30          


Leu Lys Phe Lys His Glu Leu Arg Leu Gly Phe Ser Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Tyr Ala Cys Ile Glu Pro Gln Gln Arg Met 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Arg Leu Ser Phe Asn Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Asn Gly Ser Val Ser His Tyr Ser Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  15
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  15

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp 
            20                  25                  30          


Ser Lys Phe Lys His Asn Leu Arg Leu Gly Phe Ser Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ala Asp Gly Ser Ile Tyr Ala Thr Ile Gln Pro Glu Gln Ser Gly 
    210                 215                 220                 


Lys Phe Lys His Thr Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ala Gly Ser Val Ser His Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  16
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  16

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp 
            20                  25                  30          


Ser Lys Phe Lys His Asn Leu Arg Leu Gly Phe Ser Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ala Asp Gly Ser Ile Tyr Ala Thr Ile Glu Pro Glu Gln Asp Val 
    210                 215                 220                 


Lys Phe Lys His Thr Leu Arg Leu Val Phe Asn Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Leu Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Asn Asp Lys Gly Ser Val Ser Ser Tyr Thr Leu Ser Lys Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  17
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  17

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp 
            20                  25                  30          


Ser Lys Phe Lys His Asn Leu Arg Leu Gly Phe Ser Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Glu Tyr Leu Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Tyr Ala Ser Ile Glu Pro Asn Gln Ser Pro 
    210                 215                 220                 


Lys Phe Lys His Tyr Leu Arg Leu Ala Phe Asn Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Gln Gly Ser Val Ser His Tyr Thr Leu Ser Gln Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  18
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  18

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp 
            20                  25                  30          


Ser Lys Phe Lys His Asn Leu Arg Leu Gly Phe Ser Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Lys Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ser Asp Gly Ser Ile Tyr Ala Cys Ile Glu Pro Gln Gln Arg Val 
    210                 215                 220                 


Lys Phe Lys His Ala Leu Arg Leu Ser Phe Asn Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Asn Gly Ser Val Ser His Tyr Gln Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  19
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  19

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro His Gln Asp 
            20                  25                  30          


Leu Lys Phe Lys His Glu Leu Arg Leu Gly Phe Glu Val Ser Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ala Asp Gly Ser Ile Tyr Ala Ala Ile Gln Pro Asp Gln Glu Val 
    210                 215                 220                 


Lys Phe Lys His Val Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ala Ser Ser Val Ser His Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  20
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  20

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro His Gln Asp 
            20                  25                  30          


Leu Lys Phe Lys His Glu Leu Arg Leu Gly Phe Glu Val Ser Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ala Asp Gly Ser Ile Tyr Ala Ala Ile Gln Pro Asp Gln Glu Val 
    210                 215                 220                 


Lys Phe Lys His Val Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ala Gly Ser Val Ser His Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  21
<211>  354
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  21

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Ser Ile Lys Pro His Gln Asp 
            20                  25                  30          


Leu Lys Phe Lys His Glu Leu Arg Leu Gly Phe Glu Val Gly Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser His Tyr Leu Leu Ser Gln 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Ser Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Ala Asp Gly Ser Ile Tyr Ala Ala Ile Gln Pro Asp Gln Lys Val 
    210                 215                 220                 


Lys Phe Lys His Val Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Arg Asp Ala Tyr Pro Cys Ala His Tyr Val Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  22
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  22

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro His Gln Ser Val Lys Phe Lys His Glu 
            20                  25                  30          


Leu Arg Leu Gly Phe Ser Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  23
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  23

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro Arg Gln Asp Leu Lys Phe Lys His Glu 
            20                  25                  30          


Leu Arg Leu Gly Phe Ser Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  24
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  24

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp Ser Lys Phe Lys His Asn 
            20                  25                  30          


Leu Arg Leu Gly Phe Ser Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  25
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  25

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp Ser Lys Phe Lys His Asn 
            20                  25                  30          


Leu Arg Leu Gly Phe Ser Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  26
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  26

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp Ser Lys Phe Lys His Asn 
            20                  25                  30          


Leu Arg Leu Gly Phe Ser Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  27
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  27

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro Ala Gln Asp Ser Lys Phe Lys His Asn 
            20                  25                  30          


Leu Arg Leu Gly Phe Ser Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  28
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  28

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro His Gln Asp Leu Lys Phe Lys His Glu 
            20                  25                  30          


Leu Arg Leu Gly Phe Glu Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  29
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  29

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro His Gln Asp Leu Lys Phe Lys His Glu 
            20                  25                  30          


Leu Arg Leu Gly Phe Glu Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  30
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  30

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Lys Pro His Gln Asp Leu Lys Phe Lys His Glu 
            20                  25                  30          


Leu Arg Leu Gly Phe Glu Val Gly Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Arg 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Leu Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  31
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  31

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ala Ile Gln Pro Glu Gln Ser Ser Lys Phe Lys His Thr 
            20                  25                  30          


Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Ala 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Val Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  32
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  32

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Glu Pro Gln Gln Arg Met Lys Phe Lys His Ala 
            20                  25                  30          


Leu Arg Leu Ser Phe Asn Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Asn 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Ser Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  33
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  33

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Thr Ile Gln Pro Glu Gln Ser Gly Lys Phe Lys His Thr 
            20                  25                  30          


Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Ala 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Val Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  34
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  34

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Thr Ile Glu Pro Glu Gln Asp Val Lys Phe Lys His Thr 
            20                  25                  30          


Leu Arg Leu Val Phe Asn Val Ser Gln Lys Thr Gln Arg Arg Trp Leu 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Asn Asp Lys 
    50                  55                  60                  


Gly Ser Val Ser Ser Tyr Thr Leu Ser Lys Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  35
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  35

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ser Ile Glu Pro Asn Gln Ser Pro Lys Phe Lys His Tyr 
            20                  25                  30          


Leu Arg Leu Ala Phe Asn Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Gln 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Thr Leu Ser Gln Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  36
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  36

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ser Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Cys Ile Glu Pro Gln Gln Arg Val Lys Phe Lys His Ala 
            20                  25                  30          


Leu Arg Leu Ser Phe Asn Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Asn 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Gln Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  37
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  37

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ala Ile Gln Pro Asp Gln Glu Val Lys Phe Lys His Val 
            20                  25                  30          


Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Ala 
    50                  55                  60                  


Ser Ser Val Ser His Tyr Val Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  38
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  38

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ala Ile Gln Pro Asp Gln Glu Val Lys Phe Lys His Val 
            20                  25                  30          


Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Ala 
    50                  55                  60                  


Gly Ser Val Ser His Tyr Val Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  39
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  39

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Ala Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Ala Ile Gln Pro Asp Gln Lys Val Lys Phe Lys His Val 
            20                  25                  30          


Leu Arg Leu Cys Phe Asp Val Ser Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Arg Asp Ala 
    50                  55                  60                  


Tyr Pro Cys Ala His Tyr Val Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  40
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  40
cccttacagt tattaactac tctcatgagg ttcattcc                               38


<210>  41
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  41
ggccctacaa ccattctgcc tttcactttc agtgcaata                              39


<210>  42
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  42
cacaaggggg aagagtgtga gggtgtggga taagaa                                 36


<210>  43
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  43
gagccagttg tgtaccat                                                     18


<210>  44
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  44
acgtgatccc gatttgaata                                                   20


<210>  45
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  45
gcaccttact gtcctgat                                                     18


<210>  46
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  46
ttcccagtag tacttctcca gt                                                22


<210>  47
<211>  17
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  47
tctggatggc aacaagt                                                      17


<210>  48
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  48
tgccaaaga                                                                9


<210>  49
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  49
agaccattaa ggtccc                                                       16


<210>  50
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthesized

<400>  50
tgatcccaga tgaatccac                                                    19


