                         SEQUENCE LISTING

<110>  Seattle Genetics, Inc.
 
<120>  METHODS OF REDUCING SIDE EFFECTS OF ANTI-CD30 ANTIBODY DRUG 
       CONJUGATE THERAPY

<130>  32850/52570

<150>  US 62/580,261
<151>  2017-11-01

<150>  US 62/739,635
<151>  2018-10-01

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(351)

<400>  1
cag atc cag ctg cag cag tct gga cct gag gtg gtg aag cct ggg gct         48
Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag ata tcc tgc aag gct tct ggc tac acc ttc act gac tac         96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr           
            20                  25                  30                    

tat ata acc tgg gtg aag cag aag cct gga cag gga ctt gag tgg att        144
Tyr Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga tgg att tat cct gga agc ggt aat act aag tac aat gag aag ttc        192
Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe           
    50                  55                  60                            

aag ggc aag gcc aca ttg act gta gac aca tcc tcc agc aca gcc ttc        240
Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe           
65                  70                  75                  80            

atg cag ctc agc agc ctg aca tct gag gac act gct gtc tat ttc tgt        288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys           
                85                  90                  95                

gcg aac tat ggt aac tac tgg ttt gct tac tgg ggc caa ggg act cag        336
Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln           
            100                 105                 110                   

gtc act gtc tct gca                                                    351
Val Thr Val Ser Ala                                                       
        115                                                               


<210>  2
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  2

Gln Ile Gln Leu Gln Gln Ser Gly Pro Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Thr Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Asn Tyr Gly Asn Tyr Trp Phe Ala Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  3
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  3
gactactata taacc                                                        15


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Tyr Tyr Ile Thr 
1               5   


<210>  5
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  5
tggatttatc ctggaagcgg taatactaag tacaatgaga agttcaaggg c                51


<210>  6
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  6

Trp Ile Tyr Pro Gly Ser Gly Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  7
tatggtaact actggtttgc ttac                                              24


<210>  8
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  8

Tyr Gly Asn Tyr Trp Phe Ala Tyr 
1               5               


<210>  9
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(333)

<400>  9
gac att gtg ctg acc caa tct cca gct tct ttg gct gtg tct cta ggg         48
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

cag agg gcc acc atc tcc tgc aag gcc agc caa agt gtt gat ttt gat         96
Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp           
            20                  25                  30                    

ggt gat agt tat atg aac tgg tac caa cag aaa cca gga cag cca ccc        144
Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro           
        35                  40                  45                        

aaa gtc ctc atc tat gct gca tcc aat cta gaa tct ggg atc cca gcc        192
Lys Val Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala           
    50                  55                  60                            

agg ttt agt ggc agt ggg tct ggg aca gac ttc acc ctc aac atc cat        240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His           
65                  70                  75                  80            

cct gtg gag gag gag gat gct gca acc tat tac tgt cag caa agt aat        288
Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn           
                85                  90                  95                

gag gat ccg tgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa            333
Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys               
            100                 105                 110                   


<210>  10
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Phe Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  11
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  11
aaggccagcc aaagtgttga ttttgatggt gatagttata tgaac                       45


<210>  12
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  12

Lys Ala Ser Gln Ser Val Asp Phe Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  13
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  13
gctgcatcca atctagaatc t                                                 21


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  15
cagcaaagta atgaggatcc gtggacg                                           27


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


