                               SEQUENCE LISTING

<110> MODERNATX, INC.
 
<120> LIPID NANOPARTICLES FOR DELIVERING MODIFIED RNA ENCODING A 
      VEGF-A POLYPEPTIDE

<130> 09963.0092-00304

<140>
<141>

<150> 62/579,671
<151> 2017-10-31

<160> 6     

<170> PatentIn version 3.5

<210> 1
<211> 845
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5' 7MeGppp, wherein Me = methyl and p = inorganic phosphate

<220> 
<221> source
<223> /note="Within this sequence: A = AMP, C = CMP, G = GMP, 
      U = N1-methyl-pseudoUMP"
 
<220>
<221> modified_base 
<222> (1)..(845)
<223> Monophosphate or N1-methyl-pseudo monophosphate nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> G2'OMe, wherein Me is methyl

<220>
<221> modified_base
<222> (845)..(845)
<223> GOH 3'

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 1
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gaacuuucug       60

cugucuuggg ugcauuggag ccuugccuug cugcucuacc uccaccaugc caaguggucc      120

caggcugcac ccauggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucaug      180

gaugucuauc agcgcagcua cugccaucca aucgagaccc ugguggacau cuuccaggag      240

uacccugaug agaucgagua caucuucaag ccauccugug ugccccugau gcgaugcggg      300

ggcugcugca augacgaggg ccuggagugu gugcccacug aggaguccaa caucaccaug      360

cagauuaugc ggaucaaacc ucaccaaggc cagcacauag gagagaugag cuuccuacag      420

cacaacaaau gugaaugcag accaaagaaa gauagagcaa gacaagaaaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaauguucc      540

ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agaugugaca agccgaggcg gugauaauag gcuggagccu cgguggccau gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

ucuag                                                                  845


<210> 2
<211> 191
<212> PRT
<213> Homo sapiens

<400> 2
Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala Ala Pro Met Ala Glu Gly 
            20                  25                  30          


Gly Gly Gln Asn His His Glu Val Val Lys Phe Met Asp Val Tyr Gln 
        35                  40                  45              


Arg Ser Tyr Cys His Pro Ile Glu Thr Leu Val Asp Ile Phe Gln Glu 
    50                  55                  60                  


Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys Pro Ser Cys Val Pro Leu 
65                  70                  75                  80  


Met Arg Cys Gly Gly Cys Cys Asn Asp Glu Gly Leu Glu Cys Val Pro 
                85                  90                  95      


Thr Glu Glu Ser Asn Ile Thr Met Gln Ile Met Arg Ile Lys Pro His 
            100                 105                 110         


Gln Gly Gln His Ile Gly Glu Met Ser Phe Leu Gln His Asn Lys Cys 
        115                 120                 125             


Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg Gln Glu Asn Pro Cys Gly 
    130                 135                 140                 


Pro Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr 
145                 150                 155                 160 


Cys Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln 
                165                 170                 175     


Leu Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
            180                 185                 190     


<210> 3
<211> 846
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5' 7MeGppp, wherein Me = methyl and p = inorganic phosphate

<220> 
<221> source
<223> /note="Within this sequence: A = AMP, C = CMP, G = GMP, 
      U = N1-methyl-pseudoUMP"
 
<220>
<221> modified_base 
<222> (1)..(846)
<223> Monophosphate or N1-methyl-pseudo monophosphate nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> G2'OMe, wherein Me is methyl

<220>
<221> modified_base
<222> (846)..(846)
<223> GOH 3'

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 3
ggaggaaaua agagagaaaa gaagaguaag aagaaauaua agagccacca ugaacuuucu       60

gcugucuugg gugcauugga gccuugccuu gcugcucuac cuccaccaug ccaagugguc      120

ccaggcugca cccauggcag aaggaggagg gcagaaucau cacgaagugg ugaaguucau      180

ggaugucuau cagcgcagcu acugccaucc aaucgagacc cugguggaca ucuuccagga      240

guacccugau gagaucgagu acaucuucaa gccauccugu gugccccuga ugcgaugcgg      300

gggcugcugc aaugacgagg gccuggagug ugugcccacu gaggagucca acaucaccau      360

gcagauuaug cggaucaaac cucaccaagg ccagcacaua ggagagauga gcuuccuaca      420

gcacaacaaa ugugaaugca gaccaaagaa agauagagca agacaagaaa aucccugugg      480

gccuugcuca gagcggagaa agcauuuguu uguacaagau ccgcagacgu guaaauguuc      540

cugcaaaaac acagacucgc guugcaaggc gaggcagcuu gaguuaaacg aacguacuug      600

cagaugugac aagccgaggc ggugauaaua ggcuggagcc ucgguggcca ugcuucuugc      660

cccuugggcc uccccccagc cccuccuccc cuuccugcac ccguaccccc guggucuuug      720

aauaaagucu gagugggcgg caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aucuag                                                                 846


<210> 4
<211> 845
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5' 7MeGppp, wherein Me = methyl and p = inorganic phosphate

<220> 
<221> source
<223> /note="Within this sequence: A = AMP, C = CMP, G = GMP, 
      U = N1-methyl-pseudoUMP"
 
<220>
<221> modified_base 
<222> (1)..(845)
<223> Monophosphate or N1-methyl-pseudo monophosphate nucleotide
 
<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 4
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gaacuuucuc       60

cuuucuuggg ugcauuggag ccuugccuug uuacucuacc uccaccacgc caaguggucc      120

caggccgcac ccauggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucaug      180

gacgucuauc agcgcagcua cugccaucca aucgagacac ugguggacau cuuccaggag      240

uacccugaug agaucgagua caucuucaag ccauccugug ugccccugau gcgaugcggc      300

ggcugcugca augacgaggg ccuggagugu gugccuacug aggaguccaa caucaccaug      360

cagauuaugc ggaucaaacc ucaccaaggc cagcacauag gagagaugag cuuccuacag      420

cacaacaaau gugaaugcag accaaagaaa gauagagcaa gacaagagaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaauguucc      540

ugcaagaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agaugugaca agccgaggcg gugauaauag gcuggagccu cgguggccau gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

ucuag                                                                  845


<210> 5
<211> 845
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5' 7MeGppp, wherein Me = methyl and p = inorganic phosphate

<220> 
<221> source
<223> /note="Within this sequence: A = AMP, C = CMP, G = GMP, 
      U = N1-methyl-pseudoUMP"
 
<220>
<221> modified_base 
<222> (1)..(845)
<223> Monophosphate or N1-methyl-pseudo monophosphate nucleotide
 
<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 5
gaggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccau gaacuuucug       60

cugucuuggg ugcauuggag ccuugccuug cugcucuacc uccaccaugc caaguggucc      120

caggcugcac ccauggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucaug      180

gaugucuauc agcgcagcua cugccaucca aucgagaccc ugguggacau cuuccaggag      240

uacccugaug agaucgagua caucuucaag ccauccugug ugccccugau gcgaugcggg      300

ggcugcugca augacgaggg ccuggagugu gugcccacug aggaguccaa caucaccaug      360

cagauuaugc ggaucaaacc ucaccaaggc cagcacauag gagagaugag cuuccuacag      420

cacaacaaau gugaaugcag accaaagaaa gauagagcaa gacaagaaaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaauguucc      540

ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agaugugaca agccgaggcg gugauaauag gcuggagccu cgguggccau gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

ucuag                                                                  845


<210> 6
<211> 840
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(1)
<223> 5' 7MeGppp, wherein Me = methyl and p = inorganic phosphate

<220> 
<221> source
<223> /note="Within this sequence: A = AMP, C = CMP, G = GMP, 
      U = N1-methyl-pseudoUMP"
 
<220>
<221> modified_base 
<222> (1)..(840)
<223> Monophosphate or N1-methyl-pseudo monophosphate nucleotide
 
<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 6
ggggaaauaa gagagaaaag aagaguaaga agaaauauaa gagccaccac gaacuuugug       60

cucucuuggg ugcauuggag ccuugccuug cugcucuacc uccaccacgc caaguggucc      120

caggccgcac ccacggcaga aggaggaggg cagaaucauc acgaaguggu gaaguucacg      180

gacgucuauc agcgcagcua cugccaucca aucgagaccc ucguggacau cuuccaggag      240

uacccucacg agaucgagua caucuucaag ccauccugug ugccccugac gcgacgcggg      300

ggcugcugca acgacgaggg ccucgagugu gugcccaccg aggaguccaa caccaccacg      360

cagauuacgc ggaucaaacc ucaccaaggc cagcacauag gagagacgag cuuccuacag      420

cacaacaaac gugaacgcag accaaagaaa gauagagcaa gacaagaaaa ucccuguggg      480

ccuugcucag agcggagaaa gcauuuguuu guacaagauc cgcagacgug uaaacguucc      540

ugcaaaaaca cagacucgcg uugcaaggcg aggcagcuug aguuaaacga acguacuugc      600

agacgugaca agccgaggcg gugauaauag guuggagccu cgguggccac gcuucuugcc      660

ccuugggccu ccccccagcc ccuccucccc uuccugcacc cguacccccg uggucuuuga      720

auaaagucug agugggcggc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      780

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840


