                         SEQUENCE LISTING

<110>  Cincinnati Children's Hospital Medical Center
 
<120>  FUSION PROTEINS FOR USE IN IMPROVING GENE CORRECTION VIA 
       HOMOLOGOUS RECOMBINATION

<130>  C1367.70027WO00

<140>  PCT/US2018/058254
<141>  2018-10-30

<150>  US 62/578,593
<151>  2017-10-30

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1972
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp Phe Ser Gln Gln Asp 
1               5                   10                  15      


Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro Glu Ser Gln Val Leu 
            20                  25                  30          


Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu Ser Arg His Leu Pro 
        35                  40                  45              


Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu Asp Val Val Ser Asn 
    50                  55                  60                  


Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp Gly Asn Ser Gly Phe 
65                  70                  75                  80  


Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp Pro Val Asp Ser Ser 
                85                  90                  95      


Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val Ile Glu Gln Leu Pro 
            100                 105                 110         


Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met Ser Val Glu Ser Ala 
        115                 120                 125             


Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu Glu Gln Lys Glu Lys 
    130                 135                 140                 


Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr His Ser Leu Gly Ala 
145                 150                 155                 160 


Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly Val Leu Glu Leu Ser 
                165                 170                 175     


Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro Tyr Glu Val Asp Lys 
            180                 185                 190         


Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly Tyr Thr Arg Leu Ser 
        195                 200                 205             


Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu Glu Gln Ser Asn Glu 
    210                 215                 220                 


Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp Ile Pro Val Thr Ala 
225                 230                 235                 240 


Gln Pro Ser Lys Asp Val His Val Val Lys Glu Gln Asn Pro Pro Pro 
                245                 250                 255     


Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys Ala Ser Val Ala Ala 
            260                 265                 270         


Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu Leu Met Glu Ser Gly 
        275                 280                 285             


Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val Leu Ser Thr Gln Glu 
    290                 295                 300                 


Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser Ser Asp Gly Cys Ser 
305                 310                 315                 320 


Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu Ala Ser Thr Pro Ala 
                325                 330                 335     


Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln Arg Ser Leu Val Gln 
            340                 345                 350         


Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val Ala Pro Ser Pro Asp 
        355                 360                 365             


Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser Ser Pro Thr Glu Gln 
    370                 375                 380                 


Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser Val Leu Ser Glu Glu 
385                 390                 395                 400 


Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser Gly Glu Pro Val Glu 
                405                 410                 415     


Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr Val Ser Pro Gln Ala 
            420                 425                 430         


Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe Pro Pro Gly Ser Leu 
        435                 440                 445             


Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp Ile Phe Ile Pro Ser 
    450                 455                 460                 


Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys Lys Asp Gly Asp Met 
465                 470                 475                 480 


His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys Thr Ser Glu Ile Glu 
                485                 490                 495     


Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser Leu Thr Gly Asp Ser 
            500                 505                 510         


Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser Gln Ser Pro Lys Met 
        515                 520                 525             


Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp Gly Glu Asn Thr Gln 
    530                 535                 540                 


Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu Asn Ser Lys Phe Val 
545                 550                 555                 560 


Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro Ala Gln Asp Gly Glu 
                565                 570                 575     


Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys Gly Asp Asp Thr Asp 
            580                 585                 590         


Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly Cys Lys Gly Arg Glu 
        595                 600                 605             


Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu Thr Cys Asp Ser Gly 
    610                 615                 620                 


Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser Glu Ala Leu Ser Ser 
625                 630                 635                 640 


Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys Glu His His Pro Glu 
                645                 650                 655     


Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile Pro Glu Thr Pro Cys 
            660                 665                 670         


Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn Met Glu Ser Val Pro 
        675                 680                 685             


Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln Gly Leu Cys Leu Gln 
    690                 695                 700                 


Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala Met Glu Val Glu Thr 
705                 710                 715                 720 


Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu Ala Ile Leu Asp Gln 
                725                 730                 735     


Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu Glu Ala Thr Ser Glu 
            740                 745                 750         


Asp Ser Ser Val Val Ile Val Asp Val Lys Glu Pro Ser Pro Arg Val 
        755                 760                 765             


Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu Lys Cys Ser Asp Ser 
    770                 775                 780                 


Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu Pro Cys Ala Glu Asn 
785                 790                 795                 800 


Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu Tyr Glu Gly Asp Leu 
                805                 810                 815     


Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu Gln Asp Ser Ser Gln 
            820                 825                 830         


Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro Leu Arg Leu Asp Gln 
        835                 840                 845             


Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr Ser Asn Ser Leu Thr 
    850                 855                 860                 


Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu Ser Ser Asp Ala Glu 
865                 870                 875                 880 


Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala Ser Gln Ser Phe Cys 
                885                 890                 895     


Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr Leu Pro Lys Glu Gly 
            900                 905                 910         


Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro Pro Leu Ile Gly His 
        915                 920                 925             


Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro Ile Gly Ile Ser Asn 
    930                 935                 940                 


Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val Met Ser Glu Ser Met 
945                 950                 955                 960 


Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly Lys Gly Asp Ser Gly 
                965                 970                 975     


Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu Arg Met Lys Leu Val 
            980                 985                 990         


Ser Pro Glu Thr Glu Ala Ser Glu  Glu Ser Leu Gln Phe  Asn Leu Glu 
        995                 1000                 1005             


Lys Pro  Ala Thr Gly Glu Arg  Lys Asn Gly Ser Thr  Ala Val Ala 
    1010                 1015                 1020             


Glu Ser  Val Ala Ser Pro Gln  Lys Thr Met Ser Val  Leu Ser Cys 
    1025                 1030                 1035             


Ile Cys  Glu Ala Arg Gln Glu  Asn Glu Ala Arg Ser  Glu Asp Pro 
    1040                 1045                 1050             


Pro Thr  Thr Pro Ile Arg Gly  Asn Leu Leu His Phe  Pro Ser Ser 
    1055                 1060                 1065             


Gln Gly  Glu Glu Glu Lys Glu  Lys Leu Glu Gly Asp  His Thr Ile 
    1070                 1075                 1080             


Arg Gln  Ser Gln Gln Pro Met  Lys Pro Ile Ser Pro  Val Lys Asp 
    1085                 1090                 1095             


Pro Val  Ser Pro Ala Ser Gln  Lys Met Val Ile Gln  Gly Pro Ser 
    1100                 1105                 1110             


Ser Pro  Gln Gly Glu Ala Met  Val Thr Asp Val Leu  Glu Asp Gln 
    1115                 1120                 1125             


Lys Glu  Gly Arg Ser Thr Asn  Lys Glu Asn Pro Ser  Lys Ala Leu 
    1130                 1135                 1140             


Ile Glu  Arg Pro Ser Gln Asn  Asn Ile Gly Ile Gln  Thr Met Glu 
    1145                 1150                 1155             


Cys Ser  Leu Arg Val Pro Glu  Thr Val Ser Ala Ala  Thr Gln Thr 
    1160                 1165                 1170             


Ile Lys  Asn Val Cys Glu Gln  Gly Thr Ser Thr Val  Asp Gln Asn 
    1175                 1180                 1185             


Phe Gly  Lys Gln Asp Ala Thr  Val Gln Thr Glu Arg  Gly Ser Gly 
    1190                 1195                 1200             


Glu Lys  Pro Val Ser Ala Pro  Gly Asp Asp Thr Glu  Ser Leu His 
    1205                 1210                 1215             


Ser Gln  Gly Glu Glu Glu Phe  Asp Met Pro Gln Pro  Pro His Gly 
    1220                 1225                 1230             


His Val  Leu His Arg His Met  Arg Thr Ile Arg Glu  Val Arg Thr 
    1235                 1240                 1245             


Leu Val  Thr Arg Val Ile Thr  Asp Val Tyr Tyr Val  Asp Gly Thr 
    1250                 1255                 1260             


Glu Val  Glu Arg Lys Val Thr  Glu Glu Thr Glu Glu  Pro Ile Val 
    1265                 1270                 1275             


Glu Cys  Gln Glu Cys Glu Thr  Glu Val Ser Pro Ser  Gln Thr Gly 
    1280                 1285                 1290             


Gly Ser  Ser Gly Asp Leu Gly  Asp Ile Ser Ser Phe  Ser Ser Lys 
    1295                 1300                 1305             


Ala Ser  Ser Leu His Arg Thr  Ser Ser Gly Thr Ser  Leu Ser Ala 
    1310                 1315                 1320             


Met His  Ser Ser Gly Ser Ser  Gly Lys Gly Ala Gly  Pro Leu Arg 
    1325                 1330                 1335             


Gly Lys  Thr Ser Gly Thr Glu  Pro Ala Asp Phe Ala  Leu Pro Ser 
    1340                 1345                 1350             


Ser Arg  Gly Gly Pro Gly Lys  Leu Ser Pro Arg Lys  Gly Val Ser 
    1355                 1360                 1365             


Gln Thr  Gly Thr Pro Val Cys  Glu Glu Asp Gly Asp  Ala Gly Leu 
    1370                 1375                 1380             


Gly Ile  Arg Gln Gly Gly Lys  Ala Pro Val Thr Pro  Arg Gly Arg 
    1385                 1390                 1395             


Gly Arg  Arg Gly Arg Pro Pro  Ser Arg Thr Thr Gly  Thr Arg Glu 
    1400                 1405                 1410             


Thr Ala  Val Pro Gly Pro Leu  Gly Ile Glu Asp Ile  Ser Pro Asn 
    1415                 1420                 1425             


Leu Ser  Pro Asp Asp Lys Ser  Phe Ser Arg Val Val  Pro Arg Val 
    1430                 1435                 1440             


Pro Asp  Ser Thr Arg Arg Thr  Asp Val Gly Ala Gly  Ala Leu Arg 
    1445                 1450                 1455             


Arg Ser  Asp Ser Pro Glu Ile  Pro Phe Gln Ala Ala  Ala Gly Pro 
    1460                 1465                 1470             


Ser Asp  Gly Leu Asp Ala Ser  Ser Pro Gly Asn Ser  Phe Val Gly 
    1475                 1480                 1485             


Leu Arg  Val Val Ala Lys Trp  Ser Ser Asn Gly Tyr  Phe Tyr Ser 
    1490                 1495                 1500             


Gly Lys  Ile Thr Arg Asp Val  Gly Ala Gly Lys Tyr  Lys Leu Leu 
    1505                 1510                 1515             


Phe Asp  Asp Gly Tyr Glu Cys  Asp Val Leu Gly Lys  Asp Ile Leu 
    1520                 1525                 1530             


Leu Cys  Asp Pro Ile Pro Leu  Asp Thr Glu Val Thr  Ala Leu Ser 
    1535                 1540                 1545             


Glu Asp  Glu Tyr Phe Ser Ala  Gly Val Val Lys Gly  His Arg Lys 
    1550                 1555                 1560             


Glu Ser  Gly Glu Leu Tyr Tyr  Ser Ile Glu Lys Glu  Gly Gln Arg 
    1565                 1570                 1575             


Lys Trp  Tyr Lys Arg Met Ala  Val Ile Leu Ser Leu  Glu Gln Gly 
    1580                 1585                 1590             


Asn Arg  Leu Arg Glu Gln Tyr  Gly Leu Gly Pro Tyr  Glu Ala Val 
    1595                 1600                 1605             


Thr Pro  Leu Thr Lys Ala Ala  Asp Ile Ser Leu Asp  Asn Leu Val 
    1610                 1615                 1620             


Glu Gly  Lys Arg Lys Arg Arg  Ser Asn Val Ser Ser  Pro Ala Thr 
    1625                 1630                 1635             


Pro Thr  Ala Ser Ser Ser Ser  Ser Thr Thr Pro Thr  Arg Lys Ile 
    1640                 1645                 1650             


Thr Glu  Ser Pro Arg Ala Ser  Met Gly Val Leu Ser  Gly Lys Arg 
    1655                 1660                 1665             


Lys Leu  Ile Thr Ser Glu Glu  Glu Arg Ser Pro Ala  Lys Arg Gly 
    1670                 1675                 1680             


Arg Lys  Ser Ala Thr Val Lys  Pro Gly Ala Val Gly  Ala Gly Glu 
    1685                 1690                 1695             


Phe Val  Ser Pro Cys Glu Ser  Gly Asp Asn Thr Gly  Glu Pro Ser 
    1700                 1705                 1710             


Ala Leu  Glu Glu Gln Arg Gly  Pro Leu Pro Leu Asn  Lys Thr Leu 
    1715                 1720                 1725             


Phe Leu  Gly Tyr Ala Phe Leu  Leu Thr Met Ala Thr  Thr Ser Asp 
    1730                 1735                 1740             


Lys Leu  Ala Ser Arg Ser Lys  Leu Pro Asp Gly Pro  Thr Gly Ser 
    1745                 1750                 1755             


Ser Glu  Glu Glu Glu Glu Phe  Leu Glu Ile Pro Pro  Phe Asn Lys 
    1760                 1765                 1770             


Gln Tyr  Thr Glu Ser Gln Leu  Arg Ala Gly Ala Gly  Tyr Ile Leu 
    1775                 1780                 1785             


Glu Asp  Phe Asn Glu Ala Gln  Cys Asn Thr Ala Tyr  Gln Cys Leu 
    1790                 1795                 1800             


Leu Ile  Ala Asp Gln His Cys  Arg Thr Arg Lys Tyr  Phe Leu Cys 
    1805                 1810                 1815             


Leu Ala  Ser Gly Ile Pro Cys  Val Ser His Val Trp  Val His Asp 
    1820                 1825                 1830             


Ser Cys  His Ala Asn Gln Leu  Gln Asn Tyr Arg Asn  Tyr Leu Leu 
    1835                 1840                 1845             


Pro Ala  Gly Tyr Ser Leu Glu  Glu Gln Arg Ile Leu  Asp Trp Gln 
    1850                 1855                 1860             


Pro Arg  Glu Asn Pro Phe Gln  Asn Leu Lys Val Leu  Leu Val Ser 
    1865                 1870                 1875             


Asp Gln  Gln Gln Asn Phe Leu  Glu Leu Trp Ser Glu  Ile Leu Met 
    1880                 1885                 1890             


Thr Gly  Gly Ala Ala Ser Val  Lys Gln His His Ser  Ser Ala His 
    1895                 1900                 1905             


Asn Lys  Asp Ile Ala Leu Gly  Val Phe Asp Val Val  Val Thr Asp 
    1910                 1915                 1920             


Pro Ser  Cys Pro Ala Ser Val  Leu Lys Cys Ala Glu  Ala Leu Gln 
    1925                 1930                 1935             


Leu Pro  Val Val Ser Gln Glu  Trp Val Ile Gln Cys  Leu Ile Val 
    1940                 1945                 1950             


Gly Glu  Arg Ile Gly Phe Lys  Gln His Pro Lys Tyr  Lys His Asp 
    1955                 1960                 1965             


Tyr Val  Ser His 
    1970         


<210>  2
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Pro His Gly His Val Leu His Arg His Met Arg Thr Ile Arg Glu Val 
1               5                   10                  15      


Arg Thr Leu Val Thr Arg Val Ile Thr Asp Val Tyr Tyr Val Asp Gly 
            20                  25                  30          


Thr Glu Val Glu Arg Lys Val Thr Glu Glu Thr Glu Glu Pro Ile Val 
        35                  40                  45              


Glu Cys Gln Glu Cys Glu Thr Glu Val Ser Pro Ser Gln Thr Gly Gly 
    50                  55                  60                  


Ser Ser Gly Asp Leu Gly Asp Ile Ser Ser Phe Ser Ser Lys Ala Ser 
65                  70                  75                  80  


Ser Leu His Arg Thr Ser Ser Gly Thr Ser Leu Ser Ala Met His Ser 
                85                  90                  95      


Ser Gly Ser Ser Gly Lys Gly Ala Gly Pro Leu Arg Gly Lys Thr Ser 
            100                 105                 110         


Gly Thr Glu Pro Ala Asp Phe Ala Leu Pro Ser Ser Arg Gly Gly Pro 
        115                 120                 125             


Gly Lys Leu Ser Pro Arg Lys Gly Val Ser Gln Thr Gly Thr Pro Val 
    130                 135                 140                 


Cys Glu Glu Asp Gly Asp Ala Gly Leu Gly Ile Arg Gln Gly Gly Lys 
145                 150                 155                 160 


Ala Pro Val Thr Pro Arg Gly Arg Gly Arg Arg Gly Arg Pro Pro Ser 
                165                 170                 175     


Arg Thr Thr Gly Thr Arg Glu Thr Ala Val Pro Gly Pro Leu Gly Ile 
            180                 185                 190         


Glu Asp Ile Ser Pro Asn Leu Ser Pro Asp Asp Lys Ser Phe Ser Arg 
        195                 200                 205             


Val Val Pro Arg Val Pro Asp Ser Thr Arg Arg Thr Asp Val Gly Ala 
    210                 215                 220                 


Gly Ala Leu Arg Arg Ser Asp Ser Pro Glu Ile Pro Phe Gln Ala Ala 
225                 230                 235                 240 


Ala Gly Pro Ser Asp Gly Leu Asp Ala Ser Ser Pro Gly Asn Ser Phe 
                245                 250                 255     


Val Gly Leu Arg Val Val Ala Lys Trp Ser Ser Asn Gly Tyr Phe Tyr 
            260                 265                 270         


Ser Gly Lys Ile Thr Arg Asp Val Gly Ala Gly Lys Tyr Lys Leu Leu 
        275                 280                 285             


Phe Asp Asp Gly Tyr Glu Cys Asp Val Leu Gly Lys Asp Ile Leu Leu 
    290                 295                 300                 


Cys Asp Pro Ile Pro Leu Asp Thr Glu Val Thr Ala Leu Ser Glu Asp 
305                 310                 315                 320 


Glu Tyr Phe Ser Ala Gly Val Val Lys Gly His Arg Lys Glu Ser Gly 
                325                 330                 335     


Glu Leu Tyr Tyr Ser Ile Glu Lys Glu Gly Gln Arg Lys Trp Tyr Lys 
            340                 345                 350         


Arg Met Ala Val Ile Leu Ser Leu Glu Gln Gly Asn Arg Leu Arg Glu 
        355                 360                 365             


Gln Tyr Gly Leu Gly Pro Tyr Glu Ala Val Thr Pro Leu Thr Lys Ala 
    370                 375                 380                 


Ala Asp Ile Ser Leu Asp Asn Leu Val Glu Gly Lys Arg Lys Arg Arg 
385                 390                 395                 400 


Ser Asn Val Ser Ser Pro Ala Thr Pro Thr Ala Ser Ser Ser 
                405                 410                 


<210>  3
<211>  1242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
ccacatggcc atgtcttaca tcgtcacatg agaacaatcc gggaagtacg cacacttgtc       60

actcgtgtca ttacagatgt gtattatgtg gatggaacag aagtagaaag aaaagtaact      120

gaggagactg aagagccaat tgtagagtgt caggagtgtg aaactgaagt ttccccttca      180

cagactgggg gctcctcagg tgacctgggg gatatcagct ccttctcctc caaggcatcc      240

agcttacacc gcacatcaag tgggacaagt ctctcagcta tgcacagcag tggaagctca      300

gggaaaggag ccggaccact cagagggaaa accagcggga cagaacccgc agattttgcc      360

ttacccagct cccgaggagg cccaggaaaa ctgagtccta gaaaaggggt cagtcagaca      420

gggacgccag tgtgtgagga ggatggtgat gcaggccttg gcatcagaca gggagggaag      480

gctccagtca cgcctcgtgg gcgtgggcga aggggccgcc caccttctcg gaccactgga      540

accagagaaa cagctgtgcc tggccccttg ggcatagagg acatttcacc taacttgtca      600

ccagatgata aatccttcag ccgtgtcgtg ccccgagtgc cagactccac cagacgaaca      660

gatgtgggtg ctggtgcttt gcgtcgtagt gactctccag aaattccttt ccaggctgct      720

gctggccctt ctgatggctt agatgcctcc tctccaggaa atagctttgt agggctccgt      780

gttgtagcca agtggtcatc caatggctac ttttactctg ggaaaatcac acgagatgtc      840

ggagctggga agtataaatt gctctttgat gatgggtacg aatgtgatgt gttgggcaaa      900

gacattctgt tatgtgaccc catcccgctg gacactgaag tgacggccct ctcggaggat      960

gagtatttca gtgcaggagt ggtgaaagga cataggaagg agtctgggga actgtactac     1020

agcattgaaa aagaaggcca aagaaagtgg tataagcgaa tggctgtcat cctgtccttg     1080

gagcaaggaa acagactgag agagcagtat gggcttggcc cctatgaagc agtaacacct     1140

cttacaaagg cagcagatat cagcttagac aatttggtgg aagggaagcg gaaacggaga     1200

tctaacgtca gctccccagc cacccctact gcctcctcga gc                        1242


<210>  4
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Ala Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Ala Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Ala Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  5
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  6
<211>  1795
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Asp Lys Lys Tyr Ser Ile Gly Thr Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Thr Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Thr Ile Gly 
        35                  40                  45              


Ala Thr Thr Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Thr Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Thr Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Thr Glu Glu Ser Phe Thr Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Thr Arg Lys Lys Thr Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Thr Arg Thr Ile Tyr Thr Ala Thr Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Thr Ile Glu Gly Asp Thr Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Thr Phe Ile Gln Thr Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Thr Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Thr Ser Ala Arg Thr Ser Lys Ser Arg Arg Thr Glu Asn Thr 
    210                 215                 220                 


Ile Ala Gln Thr Pro Gly Glu Lys Lys Asn Gly Thr Phe Gly Asn Thr 
225                 230                 235                 240 


Ile Ala Thr Ser Thr Gly Thr Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Thr Ala Glu Asp Ala Lys Thr Gln Thr Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Thr Asp Asn Thr Thr Ala Gln Ile Gly Asp Gln Tyr Ala Asp Thr 
        275                 280                 285             


Phe Thr Ala Ala Lys Asn Thr Ser Asp Ala Ile Thr Thr Ser Asp Ile 
    290                 295                 300                 


Thr Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Thr Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Thr Thr Thr Thr Lys Ala 
                325                 330                 335     


Thr Val Arg Gln Gln Thr Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Thr Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Thr Thr Val Lys Thr Asn Arg Glu Asp Thr Thr Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Thr Gly 
                405                 410                 415     


Glu Thr His Ala Ile Thr Arg Arg Gln Glu Asp Phe Tyr Pro Phe Thr 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Thr Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Thr Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Thr Pro Asn Glu Lys Val Thr Pro Lys His Ser Thr 
            500                 505                 510         


Thr Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Thr Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Thr Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Thr Thr Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Thr Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Thr Gly Thr 
            580                 585                 590         


Tyr His Asp Thr Thr Lys Ile Ile Lys Asp Lys Asp Phe Thr Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Thr Glu Asp Ile Val Thr Thr Thr Thr Thr 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Thr Lys Thr Tyr Ala His 
625                 630                 635                 640 


Thr Phe Asp Asp Lys Val Met Lys Gln Thr Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Thr Ser Arg Lys Thr Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Thr Asp Phe Thr Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Thr Ile His Asp Asp Ser Thr Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Thr His 
705                 710                 715                 720 


Glu His Ile Ala Asn Thr Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Thr Gln Thr Val Lys Val Val Asp Glu Thr Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Thr Gly Ser Gln Ile Thr Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Thr Gln Asn Glu Lys Thr Tyr Thr Tyr Tyr Thr Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Thr Asp Ile Asn Arg Thr 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Thr Ala Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Thr Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Thr Thr Asn Ala Lys Thr Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Thr Thr Lys Ala Glu Arg Gly Gly Thr Ser Glu Thr Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Thr Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Thr Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Thr Ile Arg Glu Val Lys Val Ile Thr Thr Lys Ser Lys 
945                 950                 955                 960 


Thr Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Thr Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Thr Ile Lys Lys Tyr  Pro Ala Thr Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Thr Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Ala Pro  Thr Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Thr Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Thr  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Thr Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Thr 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Thr Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Thr Thr Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Thr Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Thr Ile Ile  Lys Thr Pro Lys Tyr  Ser Thr Phe 
    1190                 1195                 1200             


Glu Thr  Glu Asn Gly Arg Lys  Arg Met Thr Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Thr Gln  Lys Gly Asn Glu Thr  Ala Thr Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Thr  Tyr Thr Ala Ser His  Tyr Glu Lys Thr Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Thr Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Thr  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Thr Ala Asp Ala Asn  Thr Asp Lys Val Thr  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Thr Phe Thr Thr Thr  Asn Thr Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Thr Asp Ala Thr  Thr Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Thr Tyr  Glu Thr Arg Ile Asp  Thr Ser Gln Thr Gly  Gly Asp Thr 
    1355                 1360                 1365             


Gly Ser  Thr Gly Ser Thr Gly  Ser Thr Gly Ser Met  Gly Pro His 
    1370                 1375                 1380             


Gly His  Val Leu His Arg His  Met Arg Thr Ile Arg  Glu Val Arg 
    1385                 1390                 1395             


Thr Thr  Val Thr Arg Val Ile  Thr Asp Val Tyr Tyr  Val Asp Gly 
    1400                 1405                 1410             


Thr Glu  Val Glu Arg Lys Val  Thr Glu Glu Thr Glu  Glu Pro Ile 
    1415                 1420                 1425             


Val Glu  Cys Gln Glu Cys Glu  Thr Glu Val Ser Pro  Ser Gln Thr 
    1430                 1435                 1440             


Gly Gly  Ser Ser Gly Asp Thr  Gly Asp Ile Ser Ser  Phe Ser Ser 
    1445                 1450                 1455             


Lys Ala  Ser Ser Leu His Arg  Thr Ser Ser Gly Thr  Ser Thr Ser 
    1460                 1465                 1470             


Ala Met  His Ser Ser Gly Ser  Ser Gly Lys Gly Ala  Gly Pro Thr 
    1475                 1480                 1485             


Arg Gly  Lys Thr Ser Gly Thr  Glu Pro Ala Asp Phe  Ala Leu Pro 
    1490                 1495                 1500             


Ser Ser  Arg Gly Gly Pro Gly  Lys Thr Ser Pro Arg  Lys Gly Val 
    1505                 1510                 1515             


Ser Gln  Thr Gly Thr Pro Val  Cys Glu Glu Asp Gly  Asp Ala Gly 
    1520                 1525                 1530             


Thr Gly  Ile Arg Gln Gly Gly  Lys Ala Pro Val Thr  Pro Arg Gly 
    1535                 1540                 1545             


Arg Gly  Arg Arg Gly Arg Pro  Pro Ser Arg Thr Thr  Gly Thr Arg 
    1550                 1555                 1560             


Glu Thr  Ala Val Pro Gly Pro  Leu Gly Met Glu Asp  Ile Ser Pro 
    1565                 1570                 1575             


Asn Leu  Ser Pro Asp Asp Lys  Ser Phe Ser Arg Val  Val Pro Arg 
    1580                 1585                 1590             


Val Pro  Asp Ser Thr Arg Arg  Thr Asp Val Gly Ala  Gly Ala Leu 
    1595                 1600                 1605             


Arg Arg  Ser Asp Ser Pro Glu  Ile Pro Phe Gln Ala  Ala Ala Gly 
    1610                 1615                 1620             


Pro Ser  Asp Gly Leu Asp Ala  Ser Ser Pro Gly Asn  Ser Phe Val 
    1625                 1630                 1635             


Gly Thr  Arg Val Val Ala Lys  Trp Ser Ser Asn Gly  Tyr Phe Tyr 
    1640                 1645                 1650             


Ser Gly  Lys Ile Thr Arg Asp  Val Gly Ala Gly Lys  Tyr Lys Leu 
    1655                 1660                 1665             


Thr Phe  Asp Asp Gly Tyr Glu  Cys Asp Val Leu Gly  Lys Asp Ile 
    1670                 1675                 1680             


Thr Leu  Cys Asp Pro Ile Pro  Thr Asp Thr Glu Val  Thr Ala Thr 
    1685                 1690                 1695             


Ser Glu  Asp Glu Tyr Phe Ser  Ala Gly Val Val Lys  Gly His Arg 
    1700                 1705                 1710             


Lys Glu  Ser Gly Glu Thr Tyr  Tyr Ser Ile Glu Lys  Glu Gly Gln 
    1715                 1720                 1725             


Arg Lys  Trp Tyr Lys Arg Met  Ala Val Ile Thr Ser  Leu Glu Gln 
    1730                 1735                 1740             


Gly Asn  Arg Thr Arg Glu Gln  Tyr Gly Thr Gly Pro  Tyr Glu Ala 
    1745                 1750                 1755             


Val Thr  Pro Thr Thr Lys Ala  Ala Asp Ile Ser Leu  Asp Asn Leu 
    1760                 1765                 1770             


Val Glu  Gly Lys Arg Lys Arg  Arg Ser Asn Val Ser  Ser Pro Ala 
    1775                 1780                 1785             


Thr Pro  Thr Ala Ser Ser Ser  
    1790                 1795 


<210>  7
<211>  5385
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctggc ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctgcgctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaaggcgcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga cacagggtcc acaggatcca caggcagcac agggagcatg     4140

ggaccacatg gccatgtctt acatcgtcac atgagaacaa tccgggaagt acgcacactt     4200

gtcactcgtg tcattacaga tgtgtattat gtggatggaa cagaagtaga aagaaaagta     4260

actgaggaga ctgaagagcc aattgtagag tgtcaggagt gtgaaactga agtttcccct     4320

tcacagactg ggggctcctc aggtgacctg ggggatatca gctccttctc ctccaaggca     4380

tccagcttac accgcacatc aagtgggaca agtctctcag ctatgcacag cagtggaagc     4440

tcagggaaag gagccggacc actcagaggg aaaaccagcg ggacagaacc cgcagatttt     4500

gccttaccca gctcccgagg aggcccagga aaactgagtc ctagaaaagg ggtcagtcag     4560

acagggacgc cagtgtgtga ggaggatggt gatgcaggcc ttggcatcag acagggaggg     4620

aaggctccag tcacgcctcg tgggcgtggg cgaaggggcc gcccaccttc tcggaccact     4680

ggaaccagag aaacagctgt gcctggcccc ttgggcatag aggacatttc acctaacttg     4740

tcaccagatg ataaatcctt cagccgtgtc gtgccccgag tgccagactc caccagacga     4800

acagatgtgg gtgctggtgc tttgcgtcgt agtgactctc cagaaattcc tttccaggct     4860

gctgctggcc cttctgatgg cttagatgcc tcctctccag gaaatagctt tgtagggctc     4920

cgtgttgtag ccaagtggtc atccaatggc tacttttact ctgggaaaat cacacgagat     4980

gtcggagctg ggaagtataa attgctcttt gatgatgggt acgaatgtga tgtgttgggc     5040

aaagacattc tgttatgtga ccccatcccg ctggacactg aagtgacggc cctctcggag     5100

gatgagtatt tcagtgcagg agtggtgaaa ggacatagga aggagtctgg ggaactgtac     5160

tacagcattg aaaaagaagg ccaaagaaag tggtataagc gaatggctgt catcctgtcc     5220

ttggagcaag gaaacagact gagagagcag tatgggcttg gcccctatga agcagtaaca     5280

cctcttacaa aggcagcaga tatcagctta gacaatttgg tggaagggaa gcggaaacgg     5340

agatctaacg tcagctcccc agccacccct actgcctcct cgagc                     5385


<210>  8
<211>  1796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


Thr Gly  Ser Thr Gly Ser Thr  Gly Ser Thr Gly Ser  Met Gly Pro 
    1370                 1375                 1380             


His Gly  His Val Leu His Arg  His Met Arg Thr Ile  Arg Glu Val 
    1385                 1390                 1395             


Arg Thr  Leu Val Thr Arg Val  Ile Thr Asp Val Tyr  Tyr Val Asp 
    1400                 1405                 1410             


Gly Thr  Glu Val Glu Arg Lys  Val Thr Glu Glu Thr  Glu Glu Pro 
    1415                 1420                 1425             


Ile Val  Glu Cys Gln Glu Cys  Glu Thr Glu Val Ser  Pro Ser Gln 
    1430                 1435                 1440             


Thr Gly  Gly Ser Ser Gly Asp  Leu Gly Asp Ile Ser  Ser Phe Ser 
    1445                 1450                 1455             


Ser Lys  Ala Ser Ser Leu His  Arg Thr Ser Ser Gly  Thr Ser Leu 
    1460                 1465                 1470             


Ser Ala  Met His Ser Ser Gly  Ser Ser Gly Lys Gly  Ala Gly Pro 
    1475                 1480                 1485             


Leu Arg  Gly Lys Thr Ser Gly  Thr Glu Pro Ala Asp  Phe Ala Leu 
    1490                 1495                 1500             


Pro Ser  Ser Arg Gly Gly Pro  Gly Lys Leu Ser Pro  Arg Lys Gly 
    1505                 1510                 1515             


Val Ser  Gln Thr Gly Thr Pro  Val Cys Glu Glu Asp  Gly Asp Ala 
    1520                 1525                 1530             


Gly Leu  Gly Ile Arg Gln Gly  Gly Lys Ala Pro Val  Thr Pro Arg 
    1535                 1540                 1545             


Gly Arg  Gly Arg Arg Gly Arg  Pro Pro Ser Arg Thr  Thr Gly Thr 
    1550                 1555                 1560             


Arg Glu  Thr Ala Val Pro Gly  Pro Leu Gly Ile Glu  Asp Ile Ser 
    1565                 1570                 1575             


Pro Asn  Leu Ser Pro Asp Asp  Lys Ser Phe Ser Arg  Val Val Pro 
    1580                 1585                 1590             


Arg Val  Pro Asp Ser Thr Arg  Arg Thr Asp Val Gly  Ala Gly Ala 
    1595                 1600                 1605             


Leu Arg  Arg Ser Asp Ser Pro  Glu Ile Pro Phe Gln  Ala Ala Ala 
    1610                 1615                 1620             


Gly Pro  Ser Asp Gly Leu Asp  Ala Ser Ser Pro Gly  Asn Ser Phe 
    1625                 1630                 1635             


Val Gly  Leu Arg Val Val Ala  Lys Trp Ser Ser Asn  Gly Tyr Phe 
    1640                 1645                 1650             


Tyr Ser  Gly Lys Ile Thr Arg  Asp Val Gly Ala Gly  Lys Tyr Lys 
    1655                 1660                 1665             


Leu Leu  Phe Asp Asp Gly Tyr  Glu Cys Asp Val Leu  Gly Lys Asp 
    1670                 1675                 1680             


Ile Leu  Leu Cys Asp Pro Ile  Pro Leu Asp Thr Glu  Val Thr Ala 
    1685                 1690                 1695             


Leu Ser  Glu Asp Glu Tyr Phe  Ser Ala Gly Val Val  Lys Gly His 
    1700                 1705                 1710             


Arg Lys  Glu Ser Gly Glu Leu  Tyr Tyr Ser Ile Glu  Lys Glu Gly 
    1715                 1720                 1725             


Gln Arg  Lys Trp Tyr Lys Arg  Met Ala Val Ile Leu  Ser Leu Glu 
    1730                 1735                 1740             


Gln Gly  Asn Arg Leu Arg Glu  Gln Tyr Gly Leu Gly  Pro Tyr Glu 
    1745                 1750                 1755             


Ala Val  Thr Pro Leu Thr Lys  Ala Ala Asp Ile Ser  Leu Asp Asn 
    1760                 1765                 1770             


Leu Val  Glu Gly Lys Arg Lys  Arg Arg Ser Asn Val  Ser Ser Pro 
    1775                 1780                 1785             


Ala Thr  Pro Thr Ala Ser Ser  Ser 
    1790                 1795     


<210>  9
<211>  5388
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgacacgggt tcaactggat ctacgggaag taccggcagc     4140

atggggcctc atggccacgt tctgcaccgt cacatgcgca cgattcgtga agtacgcaca     4200

ctggtcaccc gcgttattac agacgtgtac tatgtggatg gaacagaggt agagcgtaaa     4260

gtcaccgagg aaacggaaga gcctatcgtt gaatgtcagg aatgtgaaac tgaagtatcc     4320

cccagtcaga ccggagggtc ttcaggtgat cttggggata tctcgagctt ctcttccaaa     4380

gcaagttcgt tgcatcgcac aagctctgga acgtccttga gtgcaatgca cagttctggt     4440

agttcgggga aaggagccgg accactgcgt ggtaagacct ctggcaccga acctgcagat     4500

tttgcattgc catccagccg cggagggcct ggcaaactgt caccacgtaa gggggtgagc     4560

caaaccggca cacctgtttg tgaggaagat ggagatgctg gtttaggcat ccgccaaggt     4620

ggcaaggcac cagtcacccc ccgtggccgt ggacgccgcg gacgcccccc atctcgcacg     4680

acgggtacgc gtgagactgc cgtcccggga cccttgggca tcgaggatat ttcaccgaac     4740

ttgagcccag acgacaaaag ctttagccgc gtggtacccc gcgtgcccga tagcacacgc     4800

cgtacggacg tcggagctgg tgcattgcgc cgctcggaca gccccgaaat cccattccaa     4860

gcagccgccg gaccttcgga cggcttggat gcatcgtcac cggggaacag ttttgtaggg     4920

cttcgcgtcg tagctaagtg gtcttcgaat ggctactttt atagtggtaa gatcacccgt     4980

gatgttggcg caggtaaata caaactgttg ttcgacgacg gatacgaatg tgatgtctta     5040

gggaaggaca tccttctttg tgatccaatt cctttggaca cggaggtcac cgctttgtcc     5100

gaagacgagt actttagtgc gggagtcgtt aagggtcatc gtaaggaaag tggagagttg     5160

tattactcca tcgaaaaaga gggtcaacgc aagtggtaca agcgcatggc cgtaattctg     5220

tccctggaac aggggaaccg cctgcgtgag cagtacggcc tgggacctta cgaggcagtg     5280

acaccactta cgaaagcagc cgatatctca ttggacaact tggtcgaagg taagcgtaaa     5340

cgtcgttcaa acgtgtcgtc ccccgcgaca cctactgcct catcatcg                  5388


<210>  10
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
ccctccaccc cacacagtgg ggccactagg gacaggattg gtgacagaaa                  50


<210>  11
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
tttctgtcac caatcctgtc cctagtggcc ccactgtggg gtggaggg                    48


