                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Methods For Determining And Treating Cellular Resistance To 
       ADP-Ribosylating Toxin

<130>  DFS-204.25

<140>  PCT/US2018/058222
<141>  2018-10-30

<150>  US 62/579,583
<151>  2017-10-31

<160>  134   

<170>  PatentIn version 3.5

<210>  1
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcgcaggc aggtgatggc ggcgctggtc gtatccgggg cagcggagca gggcggccga       60

gacggccctg gcagaggtcg ggcccctcgg ggccgcgtgg ccaatcagat cccccctgag      120

atcctgaaga accctcagct gcaggcagca atccgggtcc tgccttccaa ctacaacttt      180

gagatcccca agaccatctg gaggatccaa caagcccagg ccaagaaggt ggccttgcaa      240

atgccggaag gcctcctcct ctttgcctgt accattgtgg atatcttgga aaggttcacg      300

gaggccgaag tgatggtgat gggtgacgtg acctacgggg cttgctgtgt ggatgacttc      360

acagcgaggg ccctgggagc tgacttcttg gtgcactacg gccacagttg cctgattccc      420

atggacacct cggcccaaga cttccgggtg ctgtacgtct ttgtggacat ccggatagac      480

actacacacc tcctggactc tctccgcctc acctttcccc cagccactgc ccttgccctg      540

gtcagcacca ttcagtttgt gtcgaccttg caggcagccg cccaggagct gaaagccgag      600

tatcgtgtga gtgtcccaca gtgcaagccc ctgtcccctg gagagatcct gggctgcaca      660

tccccccgac tgtccaaaga ggtggaggcc gttgtgtatc ttggagatgg ccgcttccat      720

ctggagtctg tcatgattgc caaccccaat gtccccgctt accggtatga cccatatagc      780

aaagtcctat ccagagaaca ctatgaccac cagcgcatgc aggctgctcg ccaagaagcc      840

atagccactg cccgctcagc taagtcctgg ggccttattc tgggcacttt gggccgccag      900

ggcagtccta agatcctgga gcacctggaa tctcgactcc gagccttggg cctttccttt      960

gtgaggctgc tgctctctga gatcttcccc agcaagctta gcctacttcc tgaggtggat     1020

gtgtgggtgc aggtggcatg tccacgtctc tccattgact ggggcacagc cttccccaag     1080

ccgctgctga caccctatga ggcggccgtg gctctgaggg acatttcctg gcagcagccc     1140

tacccgatgg acttctacgc tggcagctcc ttggggccct ggacggtgaa ccacggccag     1200

gaccgccgtc cccacgcccc gggccggccc gcgcggggga aggtgcagga ggggtccgcg     1260

cgtccccctt cggccgtggc ttgcgaggac tgcagctgca gggacgagaa ggtggcgccg     1320

ctggctcctt ga                                                         1332


<210>  2
<211>  1269
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcgcaggc aggtgatggc ggcgctggtc gtatccgggg cagcggagca gggcggccga       60

gacggccctg gcagaggtcg ggcccctcgg ggccgcgtgg ccaatcagat cccccctgag      120

atcctgaaga accctcagct gcaggcagca atccgggtcc tgccttccaa ctacaacttt      180

gagatcccca agaccatctg gaggatccaa caagcccagg ccaagaaggt ggccttgcaa      240

atgccggaag gcctcctcct ctttgcctgt accattgtgg atatcttgga aaggttcacg      300

gaggccgaag tgatggtgat gggtgacgtg acctacgggg cttgctgtgt ggatgacttc      360

acagcgaggg ccctgggagc tgacttcttg gtgcactacg gccacagttg cctgattccc      420

atggacacct cggcccaaga cttccgggtg ctgtacgtct ttgtggacat ccggatagac      480

actacacacc tcctggactc tctccgcctc acctttcccc cagccactgc ccttgccctg      540

gtcagcacca ttcagtttgt gtcgaccttg caggcagccg cccaggagct gaaagccgag      600

tatcgtgtga gtgtcccaca gtgcaagccc ctgtcccctg gagagatcct gggctgcaca      660

tccccccgac tgtccaaaga ggtggaggcc gttgtgtatc ttggagatgg ccgcttccat      720

ctggagtctg tcatgattgc caaccccaat gtccccgctt accggtatga cccatatagc      780

aaagtcctat ccagagaaca ctatgaccac cagcgcatgc aggctgctcg ccaagaagcc      840

atagccactg cccgctcaca cctggaatct cgactccgag ccttgggcct ttcctttgtg      900

aggctgctgc tctctgagat cttccccagc aagcttagcc tacttcctga ggtggatgtg      960

tgggtgcagg tggcatgtcc acgtctctcc attgactggg gcacagcctt ccccaagccg     1020

ctgctgacac cctatgaggc ggccgtggct ctgagggaca tttcctggca gcagccctac     1080

ccgatggact tctacgctgg cagctccttg gggccctgga cggtgaacca cggccaggac     1140

cgccgtcccc acgccccggg ccggcccgcg cgggggaagg tgcaggaggg gtccgcgcgt     1200

cccccttcgg ccgtggcttg cgaggactgc agctgcaggg acgagaaggt ggcgccgctg     1260

gctccttga                                                             1269


<210>  3
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcgcaggc aggtgatggc ggcgctggtc gtatccgggg cagcggagca gggcggccga       60

gacggccctg gcagaggtcg ggcccctcgg ggccgcgtgg ccaatcagat cccccctgag      120

atcctgaaga accctcagct gcaggcagca atccgggtcc tgccttccaa ctacaacttt      180

gagatcccca agaccatctg gaggatccaa caagcccagg ccaagaaggt ggccttgcaa      240

atgccggaag gcctcctcct ctttgcctgt accattgtgg atatcttgga aaggttcacg      300

gaggccgaag tgatggtgat gggtgacgtg acctacgggg cttgctgtgt ggatgacttc      360

acagcgaggg ccctgggagc tgacttcttg gtgcactacg gccacagttg cctgattccc      420

atggacacct cggcccaaga cttccgggtg ctgtacgtct ttgtggacat ccggatagac      480

actacacacc tcctggactc tctccgcctc acctttcccc cagccactgc ccttgccctg      540

gcagccgccc aggagctgaa agccgagtat cgtgtgagtg tcccacagtg caagcccctg      600

tcccctggag agatcctggg ctgcacatcc ccccgactgt ccaaagaggt ggaggccgtt      660

gtgtatcttg gagatggccg cttccatctg gagtctgtca tgattgccaa ccccaatgtc      720

cccgcttacc ggtatgaccc atatagcaaa gtcctatcca gagaacacta tgaccaccag      780

cgcatgcagg ctgctcgcca agaagccata gccactgccc gctcacacct ggaatctcga      840

ctccgagcct tgggcctttc ctttgtgagg ctgctgctct ctgagatctt ccccagcaag      900

cttagcctac ttcctgaggt ggatgtgtgg gtgcaggtgg catgtccacg tctctccatt      960

gactggggca cagccttccc caagccgctg ctgacaccct atgaggcggc cgtggctctg     1020

agggacattt cctggcagca gccctacccg atggacttct acgctggcag ctccttgggg     1080

ccctggacgg tgaaccacgg ccaggaccgc cgtccccacg ccccgggccg gcccgcgcgg     1140

gggaaggtgc aggaggggtc cgcgcgtccc ccttcggccg tggcttgcga ggactgcagc     1200

tgcagggacg agaaggtggc gccgctggct ccttga                               1236


<210>  4
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  4
atggacacct cggcccaaga cttccgggtg ctgtacgtct ttgtggacat ccggatagac       60

actacacacc tcctggactc tctccgcctc acctttcccc cagccactgc ccttgccctg      120

gtcagcacca ttcagtttgt gtcgaccttg caggcagccg cccaggagct gaaagccgag      180

tatcgtgtga gtgtcccaca gtgcaagccc ctgtcccctg gagagatcct gggctgcaca      240

tccccccgac tgtccaaaga ggtggaggcc gttgtgtatc ttggagatgg ccgcttccat      300

ctggagtctg tcatgattgc caaccccaat gtccccgctt accggtatga cccatatagc      360

aaagtcctat ccagagaaca ctatgaccac cagcgcatgc aggctgctcg ccaagaagcc      420

atagccactg cccgctcagc taagtcctgg ggccttattc tgggcacttt gggccgccag      480

ggcagtccta agatcctgga gcacctggaa tctcgactcc gagccttggg cctttccttt      540

gtgaggctgc tgctctctga gatcttcccc agcaagctta gcctacttcc tgaggtggat      600

gtgtgggtgc aggtggcatg tccacgtctc tccattgact ggggcacagc cttccccaag      660

ccgctgctga caccctatga ggcggccgtg gctctgaggg acatttcctg gcagcagccc      720

tacccgatgg acttctacgc tggcagctcc ttggggccct ggacggtgaa ccacggccag      780

gaccgccgtc cccacgcccc gggccggccc gcgcggggga aggtgcagga ggggtccgcg      840

cgtccccctt cggccgtggc ttgcgaggac tgcagctgca gggacgagaa ggtggcgccg      900

ctggctcctt ga                                                          912


<210>  5
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Arg Gln Val Met Ala Ala Leu Val Val Ser Gly Ala Ala Glu 
1               5                   10                  15      


Gln Gly Gly Arg Asp Gly Pro Gly Arg Gly Arg Ala Pro Arg Gly Arg 
            20                  25                  30          


Val Ala Asn Gln Ile Pro Pro Glu Ile Leu Lys Asn Pro Gln Leu Gln 
        35                  40                  45              


Ala Ala Ile Arg Val Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys 
    50                  55                  60                  


Thr Ile Trp Arg Ile Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Met Pro Glu Gly Leu Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu 
                85                  90                  95      


Glu Arg Phe Thr Glu Ala Glu Val Met Val Met Gly Asp Val Thr Tyr 
            100                 105                 110         


Gly Ala Cys Cys Val Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp 
        115                 120                 125             


Phe Leu Val His Tyr Gly His Ser Cys Leu Ile Pro Met Asp Thr Ser 
    130                 135                 140                 


Ala Gln Asp Phe Arg Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp 
145                 150                 155                 160 


Thr Thr His Leu Leu Asp Ser Leu Arg Leu Thr Phe Pro Pro Ala Thr 
                165                 170                 175     


Ala Leu Ala Leu Val Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala 
            180                 185                 190         


Ala Ala Gln Glu Leu Lys Ala Glu Tyr Arg Val Ser Val Pro Gln Cys 
        195                 200                 205             


Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu 
    210                 215                 220                 


Ser Lys Glu Val Glu Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His 
225                 230                 235                 240 


Leu Glu Ser Val Met Ile Ala Asn Pro Asn Val Pro Ala Tyr Arg Tyr 
                245                 250                 255     


Asp Pro Tyr Ser Lys Val Leu Ser Arg Glu His Tyr Asp His Gln Arg 
            260                 265                 270         


Met Gln Ala Ala Arg Gln Glu Ala Ile Ala Thr Ala Arg Ser Ala Lys 
        275                 280                 285             


Ser Trp Gly Leu Ile Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys 
    290                 295                 300                 


Ile Leu Glu His Leu Glu Ser Arg Leu Arg Ala Leu Gly Leu Ser Phe 
305                 310                 315                 320 


Val Arg Leu Leu Leu Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu 
                325                 330                 335     


Pro Glu Val Asp Val Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile 
            340                 345                 350         


Asp Trp Gly Thr Ala Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala 
        355                 360                 365             


Ala Val Ala Leu Arg Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp 
    370                 375                 380                 


Phe Tyr Ala Gly Ser Ser Leu Gly Pro Trp Thr Val Asn His Gly Gln 
385                 390                 395                 400 


Asp Arg Arg Pro His Ala Pro Gly Arg Pro Ala Arg Gly Lys Val Gln 
                405                 410                 415     


Glu Gly Ser Ala Arg Pro Pro Ser Ala Val Ala Cys Glu Asp Cys Ser 
            420                 425                 430         


Cys Arg Asp Glu Lys Val Ala Pro Leu Ala Pro 
        435                 440             


<210>  6
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Arg Gln Val Met Ala Ala Leu Val Val Ser Gly Ala Ala Glu 
1               5                   10                  15      


Gln Gly Gly Arg Asp Gly Pro Gly Arg Gly Arg Ala Pro Arg Gly Arg 
            20                  25                  30          


Val Ala Asn Gln Ile Pro Pro Glu Ile Leu Lys Asn Pro Gln Leu Gln 
        35                  40                  45              


Ala Ala Ile Arg Val Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys 
    50                  55                  60                  


Thr Ile Trp Arg Ile Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Met Pro Glu Gly Leu Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu 
                85                  90                  95      


Glu Arg Phe Thr Glu Ala Glu Val Met Val Met Gly Asp Val Thr Tyr 
            100                 105                 110         


Gly Ala Cys Cys Val Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp 
        115                 120                 125             


Phe Leu Val His Tyr Gly His Ser Cys Leu Ile Pro Met Asp Thr Ser 
    130                 135                 140                 


Ala Gln Asp Phe Arg Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp 
145                 150                 155                 160 


Thr Thr His Leu Leu Asp Ser Leu Arg Leu Thr Phe Pro Pro Ala Thr 
                165                 170                 175     


Ala Leu Ala Leu Val Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala 
            180                 185                 190         


Ala Ala Gln Glu Leu Lys Ala Glu Tyr Arg Val Ser Val Pro Gln Cys 
        195                 200                 205             


Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu 
    210                 215                 220                 


Ser Lys Glu Val Glu Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His 
225                 230                 235                 240 


Leu Glu Ser Val Met Ile Ala Asn Pro Asn Val Pro Ala Tyr Arg Tyr 
                245                 250                 255     


Asp Pro Tyr Ser Lys Val Leu Ser Arg Glu His Tyr Asp His Gln Arg 
            260                 265                 270         


Met Gln Ala Ala Arg Gln Glu Ala Ile Ala Thr Ala Arg Ser His Leu 
        275                 280                 285             


Glu Ser Arg Leu Arg Ala Leu Gly Leu Ser Phe Val Arg Leu Leu Leu 
    290                 295                 300                 


Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu Pro Glu Val Asp Val 
305                 310                 315                 320 


Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Thr Ala 
                325                 330                 335     


Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Arg 
            340                 345                 350         


Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Gly Ser 
        355                 360                 365             


Ser Leu Gly Pro Trp Thr Val Asn His Gly Gln Asp Arg Arg Pro His 
    370                 375                 380                 


Ala Pro Gly Arg Pro Ala Arg Gly Lys Val Gln Glu Gly Ser Ala Arg 
385                 390                 395                 400 


Pro Pro Ser Ala Val Ala Cys Glu Asp Cys Ser Cys Arg Asp Glu Lys 
                405                 410                 415     


Val Ala Pro Leu Ala Pro 
            420         


<210>  7
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Arg Gln Val Met Ala Ala Leu Val Val Ser Gly Ala Ala Glu 
1               5                   10                  15      


Gln Gly Gly Arg Asp Gly Pro Gly Arg Gly Arg Ala Pro Arg Gly Arg 
            20                  25                  30          


Val Ala Asn Gln Ile Pro Pro Glu Ile Leu Lys Asn Pro Gln Leu Gln 
        35                  40                  45              


Ala Ala Ile Arg Val Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys 
    50                  55                  60                  


Thr Ile Trp Arg Ile Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Met Pro Glu Gly Leu Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu 
                85                  90                  95      


Glu Arg Phe Thr Glu Ala Glu Val Met Val Met Gly Asp Val Thr Tyr 
            100                 105                 110         


Gly Ala Cys Cys Val Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp 
        115                 120                 125             


Phe Leu Val His Tyr Gly His Ser Cys Leu Ile Pro Met Asp Thr Ser 
    130                 135                 140                 


Ala Gln Asp Phe Arg Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp 
145                 150                 155                 160 


Thr Thr His Leu Leu Asp Ser Leu Arg Leu Thr Phe Pro Pro Ala Thr 
                165                 170                 175     


Ala Leu Ala Leu Ala Ala Ala Gln Glu Leu Lys Ala Glu Tyr Arg Val 
            180                 185                 190         


Ser Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys 
        195                 200                 205             


Thr Ser Pro Arg Leu Ser Lys Glu Val Glu Ala Val Val Tyr Leu Gly 
    210                 215                 220                 


Asp Gly Arg Phe His Leu Glu Ser Val Met Ile Ala Asn Pro Asn Val 
225                 230                 235                 240 


Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Leu Ser Arg Glu His 
                245                 250                 255     


Tyr Asp His Gln Arg Met Gln Ala Ala Arg Gln Glu Ala Ile Ala Thr 
            260                 265                 270         


Ala Arg Ser His Leu Glu Ser Arg Leu Arg Ala Leu Gly Leu Ser Phe 
        275                 280                 285             


Val Arg Leu Leu Leu Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu 
    290                 295                 300                 


Pro Glu Val Asp Val Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile 
305                 310                 315                 320 


Asp Trp Gly Thr Ala Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala 
                325                 330                 335     


Ala Val Ala Leu Arg Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp 
            340                 345                 350         


Phe Tyr Ala Gly Ser Ser Leu Gly Pro Trp Thr Val Asn His Gly Gln 
        355                 360                 365             


Asp Arg Arg Pro His Ala Pro Gly Arg Pro Ala Arg Gly Lys Val Gln 
    370                 375                 380                 


Glu Gly Ser Ala Arg Pro Pro Ser Ala Val Ala Cys Glu Asp Cys Ser 
385                 390                 395                 400 


Cys Arg Asp Glu Lys Val Ala Pro Leu Ala Pro 
                405                 410     


<210>  8
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Thr Ser Ala Gln Asp Phe Arg Val Leu Tyr Val Phe Val Asp 
1               5                   10                  15      


Ile Arg Ile Asp Thr Thr His Leu Leu Asp Ser Leu Arg Leu Thr Phe 
            20                  25                  30          


Pro Pro Ala Thr Ala Leu Ala Leu Val Ser Thr Ile Gln Phe Val Ser 
        35                  40                  45              


Thr Leu Gln Ala Ala Ala Gln Glu Leu Lys Ala Glu Tyr Arg Val Ser 
    50                  55                  60                  


Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys Thr 
65                  70                  75                  80  


Ser Pro Arg Leu Ser Lys Glu Val Glu Ala Val Val Tyr Leu Gly Asp 
                85                  90                  95      


Gly Arg Phe His Leu Glu Ser Val Met Ile Ala Asn Pro Asn Val Pro 
            100                 105                 110         


Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Leu Ser Arg Glu His Tyr 
        115                 120                 125             


Asp His Gln Arg Met Gln Ala Ala Arg Gln Glu Ala Ile Ala Thr Ala 
    130                 135                 140                 


Arg Ser Ala Lys Ser Trp Gly Leu Ile Leu Gly Thr Leu Gly Arg Gln 
145                 150                 155                 160 


Gly Ser Pro Lys Ile Leu Glu His Leu Glu Ser Arg Leu Arg Ala Leu 
                165                 170                 175     


Gly Leu Ser Phe Val Arg Leu Leu Leu Ser Glu Ile Phe Pro Ser Lys 
            180                 185                 190         


Leu Ser Leu Leu Pro Glu Val Asp Val Trp Val Gln Val Ala Cys Pro 
        195                 200                 205             


Arg Leu Ser Ile Asp Trp Gly Thr Ala Phe Pro Lys Pro Leu Leu Thr 
    210                 215                 220                 


Pro Tyr Glu Ala Ala Val Ala Leu Arg Asp Ile Ser Trp Gln Gln Pro 
225                 230                 235                 240 


Tyr Pro Met Asp Phe Tyr Ala Gly Ser Ser Leu Gly Pro Trp Thr Val 
                245                 250                 255     


Asn His Gly Gln Asp Arg Arg Pro His Ala Pro Gly Arg Pro Ala Arg 
            260                 265                 270         


Gly Lys Val Gln Glu Gly Ser Ala Arg Pro Pro Ser Ala Val Ala Cys 
        275                 280                 285             


Glu Asp Cys Ser Cys Arg Asp Glu Lys Val Ala Pro Leu Ala Pro 
    290                 295                 300             


<210>  9
<211>  1317
<212>  DNA
<213>  Mus musculus

<400>  9
atggcggcgc tggttgtgtc cgagactgcg gagccaggaa gccgagtcgg ccctggcaga       60

ggtcgcatct ctcgggggcg actggccaat cagatccccc ctgaggtcct gaacaacccc      120

cagttacagg ctgctgtcca agttctgcct tctaactaca actttgagat ccccaaaacc      180

atctggagaa tccagcaggc ccaggccaag aaggtggcct tacaaatgcc agaaggcctc      240

ctcctctttg cctgcactat tgtggatatc ttggaaaggt tcacagaggc tgaggtgatg      300

gtgatgggtg atgtcaccta tggggcttgc tgtgtggatg acttcactgc aagggccttg      360

ggagttgact tcctggtgca ctatggtcac agctgtctag tccccatgga cacctccgtt      420

caagacttcc gagtcttgta tgtcttcgtg gatatccgga tagacactgc ccaccttctg      480

gactcggtcc gcctcacctt taccccaggc agctcactcg ctctggtcag caccattcag      540

tttgtgtcaa ccttacaggc agctgcacag gagctgaaag ctgattatca catcagtgtc      600

ccacagtgca agcccctgtc ccctggggag atcctaggct gcacatcccc tcggctatcc      660

aaggaagtgg aagctgttgt gtatcttgga gatggccgct ttcatctgga gtctgtcatg      720

attgccaacc ctaatatacc tgcttaccgg tatgacccat atggcaaagt cctatccaga      780

gaatactatg accatcagcg catgcaggcc actcgccagg aagccattgc tgctgcacgc      840

tcagccaaat cctggggcct tattctggga accttgggcc gccagggcag tcccaagatc      900

ctggagcact tggaatctca gctcagaaac ttgggacttc ctttcgtgag gctgttgctc      960

tctgagatct tccccagcaa gctcagtcta cttcctgagg tggatgtgtg ggtgcaggtg     1020

gcatgtccac gcctctccat tgactggggt tcagcctttc ccaagccact gctgacaccg     1080

tacgaggcag ctgtggccct gaaggacatt tcttggcagc aaccctaccc catggacttc     1140

tactctggca gctccttagg gccatggaca gtgaactacg gtcgggaccg agcacctcgg     1200

ggtctctgcc agcctgcatc tgacaaggtg cagcaagggt ccagaggcgg ctctccagcc     1260

ccagcctgtg agagttgcaa ctgcgcagac cagaaggcta cttcgccggc tccctga        1317


<210>  10
<211>  438
<212>  PRT
<213>  Mus musculus

<400>  10

Met Ala Ala Leu Val Val Ser Glu Thr Ala Glu Pro Gly Ser Arg Val 
1               5                   10                  15      


Gly Pro Gly Arg Gly Arg Ile Ser Arg Gly Arg Leu Ala Asn Gln Ile 
            20                  25                  30          


Pro Pro Glu Val Leu Asn Asn Pro Gln Leu Gln Ala Ala Val Gln Val 
        35                  40                  45              


Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile 
    50                  55                  60                  


Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu 
65                  70                  75                  80  


Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu Glu Arg Phe Thr Glu 
                85                  90                  95      


Ala Glu Val Met Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val 
            100                 105                 110         


Asp Asp Phe Thr Ala Arg Ala Leu Gly Val Asp Phe Leu Val His Tyr 
        115                 120                 125             


Gly His Ser Cys Leu Val Pro Met Asp Thr Ser Val Gln Asp Phe Arg 
    130                 135                 140                 


Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp Thr Ala His Leu Leu 
145                 150                 155                 160 


Asp Ser Val Arg Leu Thr Phe Thr Pro Gly Ser Ser Leu Ala Leu Val 
                165                 170                 175     


Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala Ala Ala Gln Glu Leu 
            180                 185                 190         


Lys Ala Asp Tyr His Ile Ser Val Pro Gln Cys Lys Pro Leu Ser Pro 
        195                 200                 205             


Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu Ser Lys Glu Val Glu 
    210                 215                 220                 


Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His Leu Glu Ser Val Met 
225                 230                 235                 240 


Ile Ala Asn Pro Asn Ile Pro Ala Tyr Arg Tyr Asp Pro Tyr Gly Lys 
                245                 250                 255     


Val Leu Ser Arg Glu Tyr Tyr Asp His Gln Arg Met Gln Ala Thr Arg 
            260                 265                 270         


Gln Glu Ala Ile Ala Ala Ala Arg Ser Ala Lys Ser Trp Gly Leu Ile 
        275                 280                 285             


Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys Ile Leu Glu His Leu 
    290                 295                 300                 


Glu Ser Gln Leu Arg Asn Leu Gly Leu Pro Phe Val Arg Leu Leu Leu 
305                 310                 315                 320 


Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu Pro Glu Val Asp Val 
                325                 330                 335     


Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Ser Ala 
            340                 345                 350         


Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Lys 
        355                 360                 365             


Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ser Gly Ser 
    370                 375                 380                 


Ser Leu Gly Pro Trp Thr Val Asn Tyr Gly Arg Asp Arg Ala Pro Arg 
385                 390                 395                 400 


Gly Leu Cys Gln Pro Ala Ser Asp Lys Val Gln Gln Gly Ser Arg Gly 
                405                 410                 415     


Gly Ser Pro Ala Pro Ala Cys Glu Ser Cys Asn Cys Ala Asp Gln Lys 
            420                 425                 430         


Ala Thr Ser Pro Ala Pro 
        435             


<210>  11
<211>  1332
<212>  DNA
<213>  Pan troglodytes

<400>  11
atgcgcaggc aggtgatggc ggcgctggtt gtatccgggg cagcggagca gggcggccga       60

aacggccctg gcagaggtcg ggcccctcgg ggccgcgtgg ccaatcagat cccccctgag      120

atcctgaaga accctcagct gcaggcagca atgcgggtcc tgccttccaa ctacaacttt      180

gagatcccca agaccatctg gaggatccaa caagcccagg ccaagaaggt ggccttgcag      240

atgccggaag gcctcctcct ctttgcctgt accattgtgg atatcttgga aaggttcacg      300

gaggccgaag tgatggtgat gggtgacgtg acctacgggg cttgctgtgt ggatgacttc      360

acagcgaggg ccctgggagc tgacttcttg gtgcactacg gccacagttg cctgattccc      420

atggacacct cggcccaaga cttccgggtg ctgtacgtct ttgtggacat ccggatagac      480

actacgcacc tcctggactc tctccgcctc acctttcccc cagccactgc ccttgccctg      540

gtcagcacca ttcagtttgt gtcgaccttg caggcagccg cccaggagct gaaagccgag      600

tatcgtgtga gtgtcccaca gtgcaagccc ctgtcccctg gagagatcct gggctgcaca      660

tccccccgac tgtccaaaga ggtggaggcc gttgtgtatc ttggagatgg ccgcttccat      720

ctggagtctg tcatgattgc caaccccaat gtccccgctt accggtatga cccatatagc      780

aaagtcctat ccagagaaca ctatgaccac cagcgcatgc aggctgctcg ccaagaagcc      840

atagccactg cccgctcagc taagtcctgg ggccttattc tgggcacttt gggccgccag      900

ggcagtccta agatcctgga gcacctggaa tctcaactcc gagccttggg cctttccttt      960

gtgaggctgc tgctctctga gatcttcccc agcaagctta gcctacttcc cgaggtggat     1020

gtgtgggtgc aggtggcatg tccacgtctc tccattgact ggggcacagc cttccccaag     1080

ccgctgctga caccctatga ggcggccgtg gctctgaggg acatttcctg gcagcagccc     1140

tacccgatgg acttctacgc tggcagctct ttggggccct ggacggtgaa ccacggccag     1200

gaccgccgtc cccacgcccc gggccggccc gcgcggggga aggtgcagga ggggtccgcg     1260

cgtccccctt cagccgtggc ttgcgaggat tgcagctgca gggacgagaa ggtggcgccg     1320

ctggctcctt ga                                                         1332


<210>  12
<211>  443
<212>  PRT
<213>  Pan troglodytes

<400>  12

Met Arg Arg Gln Val Met Ala Ala Leu Val Val Ser Gly Ala Ala Glu 
1               5                   10                  15      


Gln Gly Gly Arg Asn Gly Pro Gly Arg Gly Arg Ala Pro Arg Gly Arg 
            20                  25                  30          


Val Ala Asn Gln Ile Pro Pro Glu Ile Leu Lys Asn Pro Gln Leu Gln 
        35                  40                  45              


Ala Ala Met Arg Val Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys 
    50                  55                  60                  


Thr Ile Trp Arg Ile Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Met Pro Glu Gly Leu Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu 
                85                  90                  95      


Glu Arg Phe Thr Glu Ala Glu Val Met Val Met Gly Asp Val Thr Tyr 
            100                 105                 110         


Gly Ala Cys Cys Val Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp 
        115                 120                 125             


Phe Leu Val His Tyr Gly His Ser Cys Leu Ile Pro Met Asp Thr Ser 
    130                 135                 140                 


Ala Gln Asp Phe Arg Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp 
145                 150                 155                 160 


Thr Thr His Leu Leu Asp Ser Leu Arg Leu Thr Phe Pro Pro Ala Thr 
                165                 170                 175     


Ala Leu Ala Leu Val Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala 
            180                 185                 190         


Ala Ala Gln Glu Leu Lys Ala Glu Tyr Arg Val Ser Val Pro Gln Cys 
        195                 200                 205             


Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu 
    210                 215                 220                 


Ser Lys Glu Val Glu Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His 
225                 230                 235                 240 


Leu Glu Ser Val Met Ile Ala Asn Pro Asn Val Pro Ala Tyr Arg Tyr 
                245                 250                 255     


Asp Pro Tyr Ser Lys Val Leu Ser Arg Glu His Tyr Asp His Gln Arg 
            260                 265                 270         


Met Gln Ala Ala Arg Gln Glu Ala Ile Ala Thr Ala Arg Ser Ala Lys 
        275                 280                 285             


Ser Trp Gly Leu Ile Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys 
    290                 295                 300                 


Ile Leu Glu His Leu Glu Ser Gln Leu Arg Ala Leu Gly Leu Ser Phe 
305                 310                 315                 320 


Val Arg Leu Leu Leu Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu 
                325                 330                 335     


Pro Glu Val Asp Val Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile 
            340                 345                 350         


Asp Trp Gly Thr Ala Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala 
        355                 360                 365             


Ala Val Ala Leu Arg Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp 
    370                 375                 380                 


Phe Tyr Ala Gly Ser Ser Leu Gly Pro Trp Thr Val Asn His Gly Gln 
385                 390                 395                 400 


Asp Arg Arg Pro His Ala Pro Gly Arg Pro Ala Arg Gly Lys Val Gln 
                405                 410                 415     


Glu Gly Ser Ala Arg Pro Pro Ser Ala Val Ala Cys Glu Asp Cys Ser 
            420                 425                 430         


Cys Arg Asp Glu Lys Val Ala Pro Leu Ala Pro 
        435                 440             


<210>  13
<211>  1317
<212>  DNA
<213>  Macaca mulatta

<400>  13
atggcggcgc tggttgtgtc ccgggcagcg gagcagggcg gccgaaacgg ccctggcaga       60

gttcgggccc ctcggggccg cgtggccaat cagatccccc ctgagatcct gaagaactcc      120

cagctgcagg cagcaatcca ggtcctgcct tccaactaca actttgagat ccccaagacc      180

atctggagga tccaacaagc ccaggccaag aaggtggcct tgcaaatgcc ggaaggcctc      240

ctcctctttg cctgtaccat cgtggatatc ttggaaaggt tcacggaggc tgaagtgatg      300

gtgatgggtg acgtgaccta tggggcttgc tgtgtggatg acttcacggc gagggccctg      360

ggagctgact tcttggtgca ctatggccac agttgcctgg ttcccatgga cacctcggcc      420

caagacttcc gggtgctgta cgtctttgtg gacatccgga tagacactgc ccacctcctg      480

gactctctcc gcctcacctt tcccccagcc accgcccttg ccctggtcag caccattcag      540

tttgtgtcga ccttgcaggc agccgcccag gagctgaaag ctgagtaccg tgtgagtgtc      600

ccacagtgca agcccctgtc ccctggagag attctgggct gcacatcccc ccgactgccc      660

gaagaggtgg aggccgttgt gtatcttgga gatggccgct tccatctgga gtctgtcatg      720

attgccaacc ccaatgtccc cgcttaccgg tatgacccgt acagcaaagt cctgtccaga      780

gagcactatg accaccagcg catgcgggct gctcgccagg aagccatagc caccgcccgc      840

tccgctaagt cctggggcct tattctgggc actctgggcc gccagggcag tcctaagatc      900

ctggagcacc tggaatctcg actccgagcc ttgggccttt ccttcgtgag gctgctgctc      960

tctgagatct tccccagcaa gcttggccta cttcccgagg tggatgtgtg ggtgcaggtg     1020

gcatgtccac gtctctccat tgactggggc acagccttcc ccaagcctct gctgacaccc     1080

tatgaggcgg ccgtggctct gagggacatt tcctggcagc agccctaccc gatggacttc     1140

tacgctggca gctccttggg gccctggacg gtgaaccacg gcctggaccg gcgtccccag     1200

accccgggcc gacccacgcg ggggaaggtg caggaggggt ccacgcatcc cccttcagcc     1260

gtggcttgcg aggactgcag ctgcagagac aagaaggtgg cgccgcttgc tccttga        1317


<210>  14
<211>  438
<212>  PRT
<213>  Macaca mulatta

<400>  14

Met Ala Ala Leu Val Val Ser Arg Ala Ala Glu Gln Gly Gly Arg Asn 
1               5                   10                  15      


Gly Pro Gly Arg Val Arg Ala Pro Arg Gly Arg Val Ala Asn Gln Ile 
            20                  25                  30          


Pro Pro Glu Ile Leu Lys Asn Ser Gln Leu Gln Ala Ala Ile Gln Val 
        35                  40                  45              


Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile 
    50                  55                  60                  


Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu 
65                  70                  75                  80  


Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu Glu Arg Phe Thr Glu 
                85                  90                  95      


Ala Glu Val Met Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val 
            100                 105                 110         


Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr 
        115                 120                 125             


Gly His Ser Cys Leu Val Pro Met Asp Thr Ser Ala Gln Asp Phe Arg 
    130                 135                 140                 


Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp Thr Ala His Leu Leu 
145                 150                 155                 160 


Asp Ser Leu Arg Leu Thr Phe Pro Pro Ala Thr Ala Leu Ala Leu Val 
                165                 170                 175     


Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala Ala Ala Gln Glu Leu 
            180                 185                 190         


Lys Ala Glu Tyr Arg Val Ser Val Pro Gln Cys Lys Pro Leu Ser Pro 
        195                 200                 205             


Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu Pro Glu Glu Val Glu 
    210                 215                 220                 


Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His Leu Glu Ser Val Met 
225                 230                 235                 240 


Ile Ala Asn Pro Asn Val Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys 
                245                 250                 255     


Val Leu Ser Arg Glu His Tyr Asp His Gln Arg Met Arg Ala Ala Arg 
            260                 265                 270         


Gln Glu Ala Ile Ala Thr Ala Arg Ser Ala Lys Ser Trp Gly Leu Ile 
        275                 280                 285             


Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys Ile Leu Glu His Leu 
    290                 295                 300                 


Glu Ser Arg Leu Arg Ala Leu Gly Leu Ser Phe Val Arg Leu Leu Leu 
305                 310                 315                 320 


Ser Glu Ile Phe Pro Ser Lys Leu Gly Leu Leu Pro Glu Val Asp Val 
                325                 330                 335     


Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Thr Ala 
            340                 345                 350         


Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Arg 
        355                 360                 365             


Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Gly Ser 
    370                 375                 380                 


Ser Leu Gly Pro Trp Thr Val Asn His Gly Leu Asp Arg Arg Pro Gln 
385                 390                 395                 400 


Thr Pro Gly Arg Pro Thr Arg Gly Lys Val Gln Glu Gly Ser Thr His 
                405                 410                 415     


Pro Pro Ser Ala Val Ala Cys Glu Asp Cys Ser Cys Arg Asp Lys Lys 
            420                 425                 430         


Val Ala Pro Leu Ala Pro 
        435             


<210>  15
<211>  1317
<212>  DNA
<213>  Bos taurus

<400>  15
atggcggcgc tggtggcggc cgaggccgca gagtcttgca gccgaaacgg cccgggcaga       60

ggtcgagccc ctcggggccg cttggccaat cagatcccgg ctgagatcct gaacaatccc      120

cagctgcagg cggccatcca agtcctgcct tccaactata actttgaggt tcccaagacc      180

atctggagga tccaacaggc ccaggccaag aaggtggcct tacaaatgcc cgaaggcctc      240

ctcctcttcg cctgtaccat tgtggatatc ttggaaaggt tcacggaggc cgaagtgatg      300

gtgatgggag acgtgaccta cggggcttgc tgtgtggacg acttcactgc aagagccttg      360

ggagctgact tcctggtcca ctatggccac agctgcctgg ttcccatgga cacctcggcc      420

caagacttcc gggtgctgta tgtctttgtg gacatccgga tagacactgc ccacctcctg      480

gactctatcc gcctcacctt tcccccagcc agtgcccttg cgctggtcag caccattcag      540

ttcgtgtcaa ccttgcaggc agctgcccaa gagctgaaag ctgagtatcg tgtgagtgtc      600

ccacagtgca agcccctgtc tcctggggag attctgggct gcacgtctcc ctgcctaccc      660

aaggaggtgg aggctgtggt gtatcttgga gatggccgct tccacctgga gtctgtcatg      720

atcgccaacc ctaacatctc cgcttaccga tacgaccctt acagcaaggt cctgtccaga      780

gagcactatg accaccagcg catgcaggcc aaccgccagg aagccatagc cactgcccgg      840

tcagctaaat cctggggtct catcctgggc actttgggcc gccaaggcag tcccaagatc      900

ctggagcacc tggaatctcg gctccaagcc ttgggacttc ccttcgtgag gctgctgctc      960

tctgagatct tccccagcaa gctcagcctc cttcccgagg tggatgtgtg ggtgcaggtg     1020

gcatgtccac gcctgtccat cgactggggt acagccttcc ccaagccgct gctcacaccc     1080

tatgaggcgg cggtggcctt gagggacatt tcctggcagc agccctaccc tatggacttc     1140

tacgccagca gctccttggg gccgtggacg gtgaaccacg ggcgggatcg gctgctccag     1200

gtcccaggcc ggctggccct ggggaaggtt cagggggggc ccgcgcgccc ctctccagcc     1260

gcggcttgcg aggcttgcag ctgcagagac gaggaggtgt cgccgatcgc tctctga        1317


<210>  16
<211>  438
<212>  PRT
<213>  Bos taurus

<400>  16

Met Ala Ala Leu Val Ala Ala Glu Ala Ala Glu Ser Cys Ser Arg Asn 
1               5                   10                  15      


Gly Pro Gly Arg Gly Arg Ala Pro Arg Gly Arg Leu Ala Asn Gln Ile 
            20                  25                  30          


Pro Ala Glu Ile Leu Asn Asn Pro Gln Leu Gln Ala Ala Ile Gln Val 
        35                  40                  45              


Leu Pro Ser Asn Tyr Asn Phe Glu Val Pro Lys Thr Ile Trp Arg Ile 
    50                  55                  60                  


Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu 
65                  70                  75                  80  


Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu Glu Arg Phe Thr Glu 
                85                  90                  95      


Ala Glu Val Met Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val 
            100                 105                 110         


Asp Asp Phe Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr 
        115                 120                 125             


Gly His Ser Cys Leu Val Pro Met Asp Thr Ser Ala Gln Asp Phe Arg 
    130                 135                 140                 


Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp Thr Ala His Leu Leu 
145                 150                 155                 160 


Asp Ser Ile Arg Leu Thr Phe Pro Pro Ala Ser Ala Leu Ala Leu Val 
                165                 170                 175     


Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala Ala Ala Gln Glu Leu 
            180                 185                 190         


Lys Ala Glu Tyr Arg Val Ser Val Pro Gln Cys Lys Pro Leu Ser Pro 
        195                 200                 205             


Gly Glu Ile Leu Gly Cys Thr Ser Pro Cys Leu Pro Lys Glu Val Glu 
    210                 215                 220                 


Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His Leu Glu Ser Val Met 
225                 230                 235                 240 


Ile Ala Asn Pro Asn Ile Ser Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys 
                245                 250                 255     


Val Leu Ser Arg Glu His Tyr Asp His Gln Arg Met Gln Ala Asn Arg 
            260                 265                 270         


Gln Glu Ala Ile Ala Thr Ala Arg Ser Ala Lys Ser Trp Gly Leu Ile 
        275                 280                 285             


Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys Ile Leu Glu His Leu 
    290                 295                 300                 


Glu Ser Arg Leu Gln Ala Leu Gly Leu Pro Phe Val Arg Leu Leu Leu 
305                 310                 315                 320 


Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu Pro Glu Val Asp Val 
                325                 330                 335     


Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Thr Ala 
            340                 345                 350         


Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Arg 
        355                 360                 365             


Asp Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Ser Ser 
    370                 375                 380                 


Ser Leu Gly Pro Trp Thr Val Asn His Gly Arg Asp Arg Leu Leu Gln 
385                 390                 395                 400 


Val Pro Gly Arg Leu Ala Leu Gly Lys Val Gln Gly Gly Pro Ala Arg 
                405                 410                 415     


Pro Ser Pro Ala Ala Ala Cys Glu Ala Cys Ser Cys Arg Asp Glu Glu 
            420                 425                 430         


Val Ser Pro Ile Ala Leu 
        435             


<210>  17
<211>  1317
<212>  DNA
<213>  Rattus norvegicus

<400>  17
atggcggcgc tggttgtgcc cgagacttcc gagccaggaa gccgagtcgg ccctggcaga       60

ggtcgcatct ctcggggccg actggccaat cagatccccc ctgagatcct gaacagtccc      120

cagctacagg ccgctgtcca tgccctgcct tctaactaca actttgagat ccccaagacc      180

atctggagga tccagcaagc ccaggccaag aaggtggcct tacaaatgcc agaaggcctc      240

ctgctctttg cctgcaccat tgtggatatc ttggaaaggt tcacaaaggc tgaggtgatg      300

gtgatgggcg atgtgaccta cggagcatgc tgtgtggacg acttcactgc aagggccttg      360

ggagttgact tcctggtgca ctatggccac agctgcctag tccccatgga cacctcagtc      420

caagacttcc gtgtgctgta tgtctttgtg gatatccgga tagacactgc ccaccttctg      480

gactcggtcc gcctcacctt caccccaggc agctcgcttg ctctggtcag caccattcag      540

tttgtgtcaa ctttacaggc agctgcccag gagctgaaag ctgattatca catcagtgtc      600

ccacagtgca agcccttgtc ccctggggag atcctaggct gcacgtcccc tcgactaccc      660

aaggaagtgg aagctgttgt gtatcttgga gatggccgct tccatctgga gtctgtcatg      720

atcgccaacc ctaatatacc tagttaccgg tacgacccat atagcaaagt cctatccaga      780

gaatactatg accatcagcg catgcaggcc actcgtcagg aagccatcgc tgctgcacgc      840

tcagccaagt tctggggcct tattctggga actttgggcc gccagggaag tcccaaggtc      900

ctggagcact tggaatctca gctcagaaac ttgggacttc ctttcctgag gctgcttctc      960

tctgagatct tccccagcaa gctcagtcta cttccttcgg tggacgtgtg ggtgcaggtg     1020

gcatgtccac gcctctccat tgactggggc tcagcctttc ccaagccact gctgacaccc     1080

tacgaggcag ctgtggccct gaaagagatt tcttggcagc aaccctaccc tatggacttc     1140

tacgctggca gctccttagg gccatggaca gtgaaccatg gtcgggaccg agcacccagg     1200

ggtctctgcc agcctgcatc cgacaaggtg cagcaggggt ccagaggcca ctctccagtc     1260

ccggcctgtg agggctgcag ctgcgcagac cagaaagcta caccgccagc tccctga        1317


<210>  18
<211>  438
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Ala Ala Leu Val Val Pro Glu Thr Ser Glu Pro Gly Ser Arg Val 
1               5                   10                  15      


Gly Pro Gly Arg Gly Arg Ile Ser Arg Gly Arg Leu Ala Asn Gln Ile 
            20                  25                  30          


Pro Pro Glu Ile Leu Asn Ser Pro Gln Leu Gln Ala Ala Val His Ala 
        35                  40                  45              


Leu Pro Ser Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile 
    50                  55                  60                  


Gln Gln Ala Gln Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu 
65                  70                  75                  80  


Leu Leu Phe Ala Cys Thr Ile Val Asp Ile Leu Glu Arg Phe Thr Lys 
                85                  90                  95      


Ala Glu Val Met Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val 
            100                 105                 110         


Asp Asp Phe Thr Ala Arg Ala Leu Gly Val Asp Phe Leu Val His Tyr 
        115                 120                 125             


Gly His Ser Cys Leu Val Pro Met Asp Thr Ser Val Gln Asp Phe Arg 
    130                 135                 140                 


Val Leu Tyr Val Phe Val Asp Ile Arg Ile Asp Thr Ala His Leu Leu 
145                 150                 155                 160 


Asp Ser Val Arg Leu Thr Phe Thr Pro Gly Ser Ser Leu Ala Leu Val 
                165                 170                 175     


Ser Thr Ile Gln Phe Val Ser Thr Leu Gln Ala Ala Ala Gln Glu Leu 
            180                 185                 190         


Lys Ala Asp Tyr His Ile Ser Val Pro Gln Cys Lys Pro Leu Ser Pro 
        195                 200                 205             


Gly Glu Ile Leu Gly Cys Thr Ser Pro Arg Leu Pro Lys Glu Val Glu 
    210                 215                 220                 


Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His Leu Glu Ser Val Met 
225                 230                 235                 240 


Ile Ala Asn Pro Asn Ile Pro Ser Tyr Arg Tyr Asp Pro Tyr Ser Lys 
                245                 250                 255     


Val Leu Ser Arg Glu Tyr Tyr Asp His Gln Arg Met Gln Ala Thr Arg 
            260                 265                 270         


Gln Glu Ala Ile Ala Ala Ala Arg Ser Ala Lys Phe Trp Gly Leu Ile 
        275                 280                 285             


Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys Val Leu Glu His Leu 
    290                 295                 300                 


Glu Ser Gln Leu Arg Asn Leu Gly Leu Pro Phe Leu Arg Leu Leu Leu 
305                 310                 315                 320 


Ser Glu Ile Phe Pro Ser Lys Leu Ser Leu Leu Pro Ser Val Asp Val 
                325                 330                 335     


Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Ser Ala 
            340                 345                 350         


Phe Pro Lys Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Lys 
        355                 360                 365             


Glu Ile Ser Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Gly Ser 
    370                 375                 380                 


Ser Leu Gly Pro Trp Thr Val Asn His Gly Arg Asp Arg Ala Pro Arg 
385                 390                 395                 400 


Gly Leu Cys Gln Pro Ala Ser Asp Lys Val Gln Gln Gly Ser Arg Gly 
                405                 410                 415     


His Ser Pro Val Pro Ala Cys Glu Gly Cys Ser Cys Ala Asp Gln Lys 
            420                 425                 430         


Ala Thr Pro Pro Ala Pro 
        435             


<210>  19
<211>  1275
<212>  DNA
<213>  Gallus gallus

<400>  19
atggccgcac cgcagcgttc cggcagcgcg gctcttctgc cctccgccaa cggcgcaggc       60

cgagccccac gtcgcactgc ccgccaggtc cccgaggagc tgctgaacaa tgtggagctg      120

cgggaggcga tgggggctct gccctccaac tacaacttcg agatccccaa aaccatctgg      180

cggatccagc aggcgggagc caaaaaggtg gccctgcaga tgccggaggg gctgctcatg      240

tttgcctgca ccatcgcaga tatcattgag cggttcacgg acgccaaggc ggtggtgatg      300

ggcgatgtga cctacggcgc gtgctgcgtg gacgactaca cagcgcgggc tctgggtgct      360

gacttcttgg tgcactatgg acacagctgc ctgatcccca tcgatgccac gcgtgggctg      420

aagatgctct acgtcttcgt ggacatcaag attgacacat cccatttcct cgacaccatc      480

cgcttcaact tcgccgtggg ctcttccctg gccctggtca gcaccatcca gttcgtggca      540

gcagtgcagg cggcctcaca ggagctgcag tcacagtaca aggtgtgcgt gccccagtgc      600

aagccgctgt cccctggtga gatactgggc tgcacatcgc cccggctcgc acgggacacc      660

gatgccattg tctatttggg ggatggccgt ttccacctgg agtccatcat gatcgccaac      720

ccggggatac ccgcctacag gtatgatccc tacagcaagg tcttctcgca ggagcattat      780

gcccatgacc gcatgcgtga agcccggcag gctgccatcc gctccgccgc ccgcgcccgg      840

tgctgggggc tgctgctggg caccctgggg cgacagggat cccccgccat cctacagcac      900

ctggagtcac ggctgcgtgc cctgggccgg ccctttgtgc gggtgctgct gtctgagatc      960

ttccccagca agctgcagct ctttgacagc gtggatgcgt gggtgcagat cgcctgtccc     1020

cggctctcca tcgactgggg ggaggcattc agcaaaccac tgctgacacc ctatgaggca     1080

gcggtggctc ttggggacat cgagtggcaa cagccgtacc ccatggactt ctatgccagt     1140

caatccctgg ggccgtggac ggccaaccac acagcgcggc ccgcccagga gaagccaccc     1200

gcaaccccca gcctgaagaa tggcactgag gggtcccgca gtgcccaccc gcctgaggac     1260

acggccacct cctga                                                      1275


<210>  20
<211>  424
<212>  PRT
<213>  Gallus gallus

<400>  20

Met Ala Ala Pro Gln Arg Ser Gly Ser Ala Ala Leu Leu Pro Ser Ala 
1               5                   10                  15      


Asn Gly Ala Gly Arg Ala Pro Arg Arg Thr Ala Arg Gln Val Pro Glu 
            20                  25                  30          


Glu Leu Leu Asn Asn Val Glu Leu Arg Glu Ala Met Gly Ala Leu Pro 
        35                  40                  45              


Ser Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile Gln Gln 
    50                  55                  60                  


Ala Gly Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu Leu Met 
65                  70                  75                  80  


Phe Ala Cys Thr Ile Ala Asp Ile Ile Glu Arg Phe Thr Asp Ala Lys 
                85                  90                  95      


Ala Val Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val Asp Asp 
            100                 105                 110         


Tyr Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr Gly His 
        115                 120                 125             


Ser Cys Leu Ile Pro Ile Asp Ala Thr Arg Gly Leu Lys Met Leu Tyr 
    130                 135                 140                 


Val Phe Val Asp Ile Lys Ile Asp Thr Ser His Phe Leu Asp Thr Ile 
145                 150                 155                 160 


Arg Phe Asn Phe Ala Val Gly Ser Ser Leu Ala Leu Val Ser Thr Ile 
                165                 170                 175     


Gln Phe Val Ala Ala Val Gln Ala Ala Ser Gln Glu Leu Gln Ser Gln 
            180                 185                 190         


Tyr Lys Val Cys Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile 
        195                 200                 205             


Leu Gly Cys Thr Ser Pro Arg Leu Ala Arg Asp Thr Asp Ala Ile Val 
    210                 215                 220                 


Tyr Leu Gly Asp Gly Arg Phe His Leu Glu Ser Ile Met Ile Ala Asn 
225                 230                 235                 240 


Pro Gly Ile Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Phe Ser 
                245                 250                 255     


Gln Glu His Tyr Ala His Asp Arg Met Arg Glu Ala Arg Gln Ala Ala 
            260                 265                 270         


Ile Arg Ser Ala Ala Arg Ala Arg Cys Trp Gly Leu Leu Leu Gly Thr 
        275                 280                 285             


Leu Gly Arg Gln Gly Ser Pro Ala Ile Leu Gln His Leu Glu Ser Arg 
    290                 295                 300                 


Leu Arg Ala Leu Gly Arg Pro Phe Val Arg Val Leu Leu Ser Glu Ile 
305                 310                 315                 320 


Phe Pro Ser Lys Leu Gln Leu Phe Asp Ser Val Asp Ala Trp Val Gln 
                325                 330                 335     


Ile Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Glu Ala Phe Ser Lys 
            340                 345                 350         


Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Gly Asp Ile Glu 
        355                 360                 365             


Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Ser Gln Ser Leu Gly 
    370                 375                 380                 


Pro Trp Thr Ala Asn His Thr Ala Arg Pro Ala Gln Glu Lys Pro Pro 
385                 390                 395                 400 


Ala Thr Pro Ser Leu Lys Asn Gly Thr Glu Gly Ser Arg Ser Ala His 
                405                 410                 415     


Pro Pro Glu Asp Thr Ala Thr Ser 
            420                 


<210>  21
<211>  1434
<212>  DNA
<213>  Gallus gallus

<400>  21
atgttcgacg gggcggcggt gaataacgga gcgctgcccc ccttcccacc cccccgccgg       60

ctgtggggga gaacgctgct gagtgcccgc tggtgggaag ggggccgagc cccacgtcgc      120

actgcccgcc aggtccccga ggagctgctg aacaatgtgg agctgcggga ggcgatgggg      180

gctctgccct ccaactacaa cttcgagatc cccaaaacca tctggcggat ccagcaggcg      240

ggagccaaaa aggtggccct gcagatgccg gaggggctgc tcatgtttgc ctgcaccatc      300

gcagatatca ttgagcggtt cacggacgcc aaggcggtgg tgatgggcga tgtgacctac      360

ggcgcgtgct gcgtggacga ctacacagcg cgggctctgg gtgctgactt cttggtgcac      420

tatggacaca gctgcctgat ccccatcgat gccacgcgtg ggctgaagat gctctacgtc      480

ttcgtggaca tcaagattga cacatcccat ttcctcgaca ccatccgctt caacttcgcc      540

gtgggctctt ccctggccct ggtcagcacc atccagttcg tggcagcagt gcaggcggcc      600

tcacaggagc tgcagtcaca gtacaaggtg tgcgtgcccc agtgcaagcc gctgtcccct      660

ggtgagatac tgggctgcac atcgccccgg ctcgcacggg acaccgatgc cattgtctat      720

ttgggggatg gccgtttcca cctggagtcc atcatgatcg ccaacccggg gatacccgcc      780

tacaggtatg atccctacag caaggtcttc tcgcaggagc attatgccca tgaccgcatg      840

cgtgaagccc ggcaggctgc catccgctcc gccgcccgcg cccggtgctg ggggctgctg      900

ctgggcaccc tggggcgaca gggatccccc gccatcctac agcacctgga gtcacggctg      960

cgtgccctgg gccggccctt tgtgcgggtg ctgctgtctg agatcttccc cagcaagctg     1020

cagctctttg acagcgtgga tgcgtgggtg cagatcgcct gtccccggct ctccatcgac     1080

tggggggagg cattcagcaa accactgctg acaccctatg aggcagcggt ggctcttggg     1140

gacatcgagt ggcaacagcc gtaccccatg gacttctatg ccagtcaatc cctggggccg     1200

tggacggcca accacacagc gcggcccgcc caggtaggct ctggggggtg gggggggccc     1260

ccctgtgtcc cctggtgctc gctgccatgt ggcacaagcg ccacccagtg gctcgctccc     1320

tggagagcag ggctggcgcc cacccggtgc cctccatcgg ggcacacatg gccccatctt     1380

tgcttacccc atgtctgtcc ctacaggaga agccacccgc aacccccagc ctga           1434


<210>  22
<211>  477
<212>  PRT
<213>  Gallus gallus

<400>  22

Met Phe Asp Gly Ala Ala Val Asn Asn Gly Ala Leu Pro Pro Phe Pro 
1               5                   10                  15      


Pro Pro Arg Arg Leu Trp Gly Arg Thr Leu Leu Ser Ala Arg Trp Trp 
            20                  25                  30          


Glu Gly Gly Arg Ala Pro Arg Arg Thr Ala Arg Gln Val Pro Glu Glu 
        35                  40                  45              


Leu Leu Asn Asn Val Glu Leu Arg Glu Ala Met Gly Ala Leu Pro Ser 
    50                  55                  60                  


Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile Gln Gln Ala 
65                  70                  75                  80  


Gly Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu Leu Met Phe 
                85                  90                  95      


Ala Cys Thr Ile Ala Asp Ile Ile Glu Arg Phe Thr Asp Ala Lys Ala 
            100                 105                 110         


Val Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val Asp Asp Tyr 
        115                 120                 125             


Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr Gly His Ser 
    130                 135                 140                 


Cys Leu Ile Pro Ile Asp Ala Thr Arg Gly Leu Lys Met Leu Tyr Val 
145                 150                 155                 160 


Phe Val Asp Ile Lys Ile Asp Thr Ser His Phe Leu Asp Thr Ile Arg 
                165                 170                 175     


Phe Asn Phe Ala Val Gly Ser Ser Leu Ala Leu Val Ser Thr Ile Gln 
            180                 185                 190         


Phe Val Ala Ala Val Gln Ala Ala Ser Gln Glu Leu Gln Ser Gln Tyr 
        195                 200                 205             


Lys Val Cys Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile Leu 
    210                 215                 220                 


Gly Cys Thr Ser Pro Arg Leu Ala Arg Asp Thr Asp Ala Ile Val Tyr 
225                 230                 235                 240 


Leu Gly Asp Gly Arg Phe His Leu Glu Ser Ile Met Ile Ala Asn Pro 
                245                 250                 255     


Gly Ile Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Phe Ser Gln 
            260                 265                 270         


Glu His Tyr Ala His Asp Arg Met Arg Glu Ala Arg Gln Ala Ala Ile 
        275                 280                 285             


Arg Ser Ala Ala Arg Ala Arg Cys Trp Gly Leu Leu Leu Gly Thr Leu 
    290                 295                 300                 


Gly Arg Gln Gly Ser Pro Ala Ile Leu Gln His Leu Glu Ser Arg Leu 
305                 310                 315                 320 


Arg Ala Leu Gly Arg Pro Phe Val Arg Val Leu Leu Ser Glu Ile Phe 
                325                 330                 335     


Pro Ser Lys Leu Gln Leu Phe Asp Ser Val Asp Ala Trp Val Gln Ile 
            340                 345                 350         


Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Glu Ala Phe Ser Lys Pro 
        355                 360                 365             


Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Gly Asp Ile Glu Trp 
    370                 375                 380                 


Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Ser Gln Ser Leu Gly Pro 
385                 390                 395                 400 


Trp Thr Ala Asn His Thr Ala Arg Pro Ala Gln Val Gly Ser Gly Gly 
                405                 410                 415     


Trp Gly Gly Pro Pro Cys Val Pro Trp Cys Ser Leu Pro Cys Gly Thr 
            420                 425                 430         


Ser Ala Thr Gln Trp Leu Ala Pro Trp Arg Ala Gly Leu Ala Pro Thr 
        435                 440                 445             


Arg Cys Pro Pro Ser Gly His Thr Trp Pro His Leu Cys Leu Pro His 
    450                 455                 460                 


Val Cys Pro Tyr Arg Arg Ser His Pro Gln Pro Pro Ala 
465                 470                 475         


<210>  23
<211>  1389
<212>  DNA
<213>  Gallus gallus

<400>  23
atggccgcac cgcagcgttc cggcagcgcg gctcttctgc cctccgccaa cggcgcaggc       60

cgagccccac gtcgcactgc ccgccaggtc cccgaggagc tgctgaacaa tgtggagctg      120

cgggaggcga tgggggctct gccctccaac tacaacttcg agatccccaa aaccatctgg      180

cggatccagc aggcgggagc caaaaaggtg gccctgcaga tgccggaggg gctgctcatg      240

tttgcctgca ccatcgcaga tatcattgag cggttcacgg acgccaaggc ggtggtgatg      300

ggcgatgtga cctacggcgc gtgctgcgtg gacgactaca cagcgcgggc tctgggtgct      360

gacttcttgg tgcactatgg acacagctgc ctgatcccca tcgatgccac gcgtgggctg      420

aagatgctct acgtcttcgt ggacatcaag attgacacat cccatttcct cgacaccatc      480

cgcttcaact tcgccgtggg ctcttccctg gccctggtca gcaccatcca gttcgtggca      540

gcagtgcagg cggcctcaca ggagctgcag tcacagtaca aggtgtgcgt gccccagtgc      600

aagccgctgt cccctggtga gatactgggc tgcacatcgc cccggctcgc acgggacacc      660

gatgccattg tctatttggg ggatggccgt ttccacctgg agtccatcat gatcgccaac      720

ccggggatac ccgcctacag gtatgatccc tacagcaagg tcttctcgca ggagcattat      780

gcccatgacc gcatgcgtga agcccggcag gctgccatcc gctccgccgc ccgcgcccgg      840

tgctgggggc tgctgctggg caccctgggg cgacagggat cccccgccat cctacagcac      900

ctggagtcac ggctgcgtgc cctgggccgg ccctttgtgc gggtgctgct gtctgagatc      960

ttccccagca agctgcagct ctttgacagc gtggatgcgt gggtgcagat cgcctgtccc     1020

cggctctcca tcgactgggg ggaggcattc agcaaaccac tgctgacacc ctatgaggca     1080

gcggtggctc ttggggacat cgagtggcaa cagccgtacc ccatggactt ctatgccagt     1140

caatccctgg ggccgtggac ggccaaccac acagcgcggc ccgcccaggt aggctctggg     1200

gggtgggggg ggcccccctg tgtcccctgg tgctcgctgc catgtggcac aagcgccacc     1260

cagtggctcg ctccctggag agcagggctg gcgcccaccc ggtgccctcc atcggggcac     1320

acatggcccc atctttgctt accccatgtc tgtccctaca ggagaagcca cccgcaaccc     1380

ccagcctga                                                             1389


<210>  24
<211>  462
<212>  PRT
<213>  Gallus gallus

<400>  24

Met Ala Ala Pro Gln Arg Ser Gly Ser Ala Ala Leu Leu Pro Ser Ala 
1               5                   10                  15      


Asn Gly Ala Gly Arg Ala Pro Arg Arg Thr Ala Arg Gln Val Pro Glu 
            20                  25                  30          


Glu Leu Leu Asn Asn Val Glu Leu Arg Glu Ala Met Gly Ala Leu Pro 
        35                  40                  45              


Ser Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile Gln Gln 
    50                  55                  60                  


Ala Gly Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu Leu Met 
65                  70                  75                  80  


Phe Ala Cys Thr Ile Ala Asp Ile Ile Glu Arg Phe Thr Asp Ala Lys 
                85                  90                  95      


Ala Val Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val Asp Asp 
            100                 105                 110         


Tyr Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr Gly His 
        115                 120                 125             


Ser Cys Leu Ile Pro Ile Asp Ala Thr Arg Gly Leu Lys Met Leu Tyr 
    130                 135                 140                 


Val Phe Val Asp Ile Lys Ile Asp Thr Ser His Phe Leu Asp Thr Ile 
145                 150                 155                 160 


Arg Phe Asn Phe Ala Val Gly Ser Ser Leu Ala Leu Val Ser Thr Ile 
                165                 170                 175     


Gln Phe Val Ala Ala Val Gln Ala Ala Ser Gln Glu Leu Gln Ser Gln 
            180                 185                 190         


Tyr Lys Val Cys Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile 
        195                 200                 205             


Leu Gly Cys Thr Ser Pro Arg Leu Ala Arg Asp Thr Asp Ala Ile Val 
    210                 215                 220                 


Tyr Leu Gly Asp Gly Arg Phe His Leu Glu Ser Ile Met Ile Ala Asn 
225                 230                 235                 240 


Pro Gly Ile Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Phe Ser 
                245                 250                 255     


Gln Glu His Tyr Ala His Asp Arg Met Arg Glu Ala Arg Gln Ala Ala 
            260                 265                 270         


Ile Arg Ser Ala Ala Arg Ala Arg Cys Trp Gly Leu Leu Leu Gly Thr 
        275                 280                 285             


Leu Gly Arg Gln Gly Ser Pro Ala Ile Leu Gln His Leu Glu Ser Arg 
    290                 295                 300                 


Leu Arg Ala Leu Gly Arg Pro Phe Val Arg Val Leu Leu Ser Glu Ile 
305                 310                 315                 320 


Phe Pro Ser Lys Leu Gln Leu Phe Asp Ser Val Asp Ala Trp Val Gln 
                325                 330                 335     


Ile Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Glu Ala Phe Ser Lys 
            340                 345                 350         


Pro Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Gly Asp Ile Glu 
        355                 360                 365             


Trp Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Ser Gln Ser Leu Gly 
    370                 375                 380                 


Pro Trp Thr Ala Asn His Thr Ala Arg Pro Ala Gln Val Gly Ser Gly 
385                 390                 395                 400 


Gly Trp Gly Gly Pro Pro Cys Val Pro Trp Cys Ser Leu Pro Cys Gly 
                405                 410                 415     


Thr Ser Ala Thr Gln Trp Leu Ala Pro Trp Arg Ala Gly Leu Ala Pro 
            420                 425                 430         


Thr Arg Cys Pro Pro Ser Gly His Thr Trp Pro His Leu Cys Leu Pro 
        435                 440                 445             


His Val Cys Pro Tyr Arg Arg Ser His Pro Gln Pro Pro Ala 
    450                 455                 460         


<210>  25
<211>  1341
<212>  DNA
<213>  Gallus gallus

<400>  25
atgttcgacg gggcggcggt gaataacgga gcgctgcccc ccttcccacc cccccgccgg       60

ctgtggggga gaacgctgct gagtgcccgc tggtgggaag ggggccgagc cccacgtcgc      120

actgcccgcc aggtccccga ggagctgctg aacaatgtgg agctgcggga ggcgatgggg      180

gctctgccct ccaactacaa cttcgagatc cccaaaacca tctggcggat ccagcaggcg      240

ggagccaaaa aggtggccct gcagatgccg gaggggctgc tcatgtttgc ctgcaccatc      300

gcagatatca ttgagcggtt cacggacgcc aaggcggtgg tgatgggcga tgtgacctac      360

ggcgcgtgct gcgtggacga ctacacagcg cgggctctgg gtgctgactt cttggtgcac      420

tatggacaca gctgcctgat ccccatcgat gccacgcgtg ggctgaagat gctctacgtc      480

ttcgtggaca tcaagattga cacatcccat ttcctcgaca ccatccgctt caacttcgcc      540

gtgggctctt ccctggccct ggtcagcacc atccagttcg tggcagcagt gcaggcggcc      600

tcacaggagc tgcagtcaca gtacaaggtg tgcgtgcccc agtgcaagcc gctgtcccct      660

ggtgagatac tgggctgcac atcgccccgg ctcgcacggg acaccgatgc cattgtctat      720

ttgggggatg gccgtttcca cctggagtcc atcatgatcg ccaacccggg gatacccgcc      780

tacaggtatg atccctacag caaggtcttc tcgcaggagc attatgccca tgaccgcatg      840

cgtgaagccc ggcaggctgc catccgctcc gccgcccgcg cccggtgctg ggggctgctg      900

ctgggcaccc tggggcgaca gggatccccc gccatcctac agcacctgga gtcacggctg      960

cgtgccctgg gccggccctt tgtgcgggtg ctgctgtctg agatcttccc cagcaagctg     1020

cagctctttg acagcgtgga tgcgtgggtg cagatcgcct gtccccggct ctccatcgac     1080

tggggggagg cattcagcaa accactgctg acaccctatg aggtgagcag tccccggtgg     1140

gtttcgggag gacccctccc agccctgcgc gtggcactca gccccttatc ccctcctcac     1200

aggcagcggt ggctcttggg gacatcgagt ggcaacagcc gtaccccatg gacttctatg     1260

ccagtcaatc cctggggccg tggacggcca accacacagc gcggcccgcc caggagaagc     1320

cacccgcaac ccccagcctg a                                               1341


<210>  26
<211>  446
<212>  PRT
<213>  Gallus gallus

<400>  26

Met Phe Asp Gly Ala Ala Val Asn Asn Gly Ala Leu Pro Pro Phe Pro 
1               5                   10                  15      


Pro Pro Arg Arg Leu Trp Gly Arg Thr Leu Leu Ser Ala Arg Trp Trp 
            20                  25                  30          


Glu Gly Gly Arg Ala Pro Arg Arg Thr Ala Arg Gln Val Pro Glu Glu 
        35                  40                  45              


Leu Leu Asn Asn Val Glu Leu Arg Glu Ala Met Gly Ala Leu Pro Ser 
    50                  55                  60                  


Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile Gln Gln Ala 
65                  70                  75                  80  


Gly Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu Leu Met Phe 
                85                  90                  95      


Ala Cys Thr Ile Ala Asp Ile Ile Glu Arg Phe Thr Asp Ala Lys Ala 
            100                 105                 110         


Val Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val Asp Asp Tyr 
        115                 120                 125             


Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr Gly His Ser 
    130                 135                 140                 


Cys Leu Ile Pro Ile Asp Ala Thr Arg Gly Leu Lys Met Leu Tyr Val 
145                 150                 155                 160 


Phe Val Asp Ile Lys Ile Asp Thr Ser His Phe Leu Asp Thr Ile Arg 
                165                 170                 175     


Phe Asn Phe Ala Val Gly Ser Ser Leu Ala Leu Val Ser Thr Ile Gln 
            180                 185                 190         


Phe Val Ala Ala Val Gln Ala Ala Ser Gln Glu Leu Gln Ser Gln Tyr 
        195                 200                 205             


Lys Val Cys Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile Leu 
    210                 215                 220                 


Gly Cys Thr Ser Pro Arg Leu Ala Arg Asp Thr Asp Ala Ile Val Tyr 
225                 230                 235                 240 


Leu Gly Asp Gly Arg Phe His Leu Glu Ser Ile Met Ile Ala Asn Pro 
                245                 250                 255     


Gly Ile Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Phe Ser Gln 
            260                 265                 270         


Glu His Tyr Ala His Asp Arg Met Arg Glu Ala Arg Gln Ala Ala Ile 
        275                 280                 285             


Arg Ser Ala Ala Arg Ala Arg Cys Trp Gly Leu Leu Leu Gly Thr Leu 
    290                 295                 300                 


Gly Arg Gln Gly Ser Pro Ala Ile Leu Gln His Leu Glu Ser Arg Leu 
305                 310                 315                 320 


Arg Ala Leu Gly Arg Pro Phe Val Arg Val Leu Leu Ser Glu Ile Phe 
                325                 330                 335     


Pro Ser Lys Leu Gln Leu Phe Asp Ser Val Asp Ala Trp Val Gln Ile 
            340                 345                 350         


Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Glu Ala Phe Ser Lys Pro 
        355                 360                 365             


Leu Leu Thr Pro Tyr Glu Val Ser Ser Pro Arg Trp Val Ser Gly Gly 
    370                 375                 380                 


Pro Leu Pro Ala Leu Arg Val Ala Leu Ser Pro Leu Ser Pro Pro His 
385                 390                 395                 400 


Arg Gln Arg Trp Leu Leu Gly Thr Ser Ser Gly Asn Ser Arg Thr Pro 
                405                 410                 415     


Trp Thr Ser Met Pro Val Asn Pro Trp Gly Arg Gly Arg Pro Thr Thr 
            420                 425                 430         


Gln Arg Gly Pro Pro Arg Arg Ser His Pro Gln Pro Pro Ala 
        435                 440                 445     


<210>  27
<211>  1319
<212>  DNA
<213>  Gallus gallus

<400>  27
atgttcgacg gggcggcggt gaataacgga gcgctgcccc ccttcccacc cccccgccgg       60

ctgtggggga gaacgctgct gagtgcccgc tggtgggaag ggggccgagc cccacgtcgc      120

actgcccgcc aggtccccga ggagctgctg aacaatgtgg agctgcggga ggcgatgggg      180

gctctgccct ccaactacaa cttcgagatc cccaaaacca tctggcggat ccagcaggcg      240

ggagccaaaa aggtggccct gcagatgccg gaggggctgc tcatgtttgc ctgcaccatc      300

gcagatatca ttgagcggtt cacggacgcc aaggcggtgg tgatgggcga tgtgacctac      360

ggcgcgtgct gcgtggacga ctacacagcg cgggctctgg gtgctgactt cttggtgcac      420

tatggacaca gctgcctgat ccccatcgat gccacgcgtg ggctgaagat gctctacgtc      480

ttcgtggaca tcaagattga cacatcccat ttcctcgaca ccatccgctt caacttcgcc      540

gtgggctctt ccctggccct ggtcagcacc atccagttcg tggcagcagt gcaggcggcc      600

tcacaggagc tgcagtcaca gtacaaggtg tgcgtgcccc agtgcaagcc gctgtcccct      660

ggtgagatac tgggctgcac atcgccccgg ctcgcacggg acaccgatgc cattgtctat      720

ttgggggatg gccgtttcca cctggagtcc atcatgatcg ccaacccggg gatacccgcc      780

tacaggtatg atccctacag caaggtcttc tcgcaggagc attatgccca tgaccgcatg      840

cgtgaagccc ggcaggctgc catccgctcc gccgcccgcg cccggtgctg ggggctgctg      900

ctgggcaccc tggggcgaca gggatccccc gccatcctac agcacctgga gtcacggctg      960

cgtgccctgg gccggccctt tgtgcgggtg ctgctgtctg agatcttccc cagcaagctg     1020

cagctctttg acagcgtgga tgcgtgggtg cagatcgcct gtccccggct ctccatcgac     1080

tggggggagg cattcagcaa accactgctg acaccctatg aggcagcggt ggctcttggg     1140

gacatcgagt ggcaacagcc gtaccccatg gacttctatg ccagtcaatc cctggggccg     1200

tggacggcca accacacagc gcggcccgcc caggagaagc cacccgcaac ccccagcctg     1260

aagaatggca ctgaggggtc ccgcagtgcc cacccgcctg aggacacggc cacctcctg      1319


<210>  28
<211>  439
<212>  PRT
<213>  Gallus gallus

<400>  28

Met Phe Asp Gly Ala Ala Val Asn Asn Gly Ala Leu Pro Pro Phe Pro 
1               5                   10                  15      


Pro Pro Arg Arg Leu Trp Gly Arg Thr Leu Leu Ser Ala Arg Trp Trp 
            20                  25                  30          


Glu Gly Gly Arg Ala Pro Arg Arg Thr Ala Arg Gln Val Pro Glu Glu 
        35                  40                  45              


Leu Leu Asn Asn Val Glu Leu Arg Glu Ala Met Gly Ala Leu Pro Ser 
    50                  55                  60                  


Asn Tyr Asn Phe Glu Ile Pro Lys Thr Ile Trp Arg Ile Gln Gln Ala 
65                  70                  75                  80  


Gly Ala Lys Lys Val Ala Leu Gln Met Pro Glu Gly Leu Leu Met Phe 
                85                  90                  95      


Ala Cys Thr Ile Ala Asp Ile Ile Glu Arg Phe Thr Asp Ala Lys Ala 
            100                 105                 110         


Val Val Met Gly Asp Val Thr Tyr Gly Ala Cys Cys Val Asp Asp Tyr 
        115                 120                 125             


Thr Ala Arg Ala Leu Gly Ala Asp Phe Leu Val His Tyr Gly His Ser 
    130                 135                 140                 


Cys Leu Ile Pro Ile Asp Ala Thr Arg Gly Leu Lys Met Leu Tyr Val 
145                 150                 155                 160 


Phe Val Asp Ile Lys Ile Asp Thr Ser His Phe Leu Asp Thr Ile Arg 
                165                 170                 175     


Phe Asn Phe Ala Val Gly Ser Ser Leu Ala Leu Val Ser Thr Ile Gln 
            180                 185                 190         


Phe Val Ala Ala Val Gln Ala Ala Ser Gln Glu Leu Gln Ser Gln Tyr 
        195                 200                 205             


Lys Val Cys Val Pro Gln Cys Lys Pro Leu Ser Pro Gly Glu Ile Leu 
    210                 215                 220                 


Gly Cys Thr Ser Pro Arg Leu Ala Arg Asp Thr Asp Ala Ile Val Tyr 
225                 230                 235                 240 


Leu Gly Asp Gly Arg Phe His Leu Glu Ser Ile Met Ile Ala Asn Pro 
                245                 250                 255     


Gly Ile Pro Ala Tyr Arg Tyr Asp Pro Tyr Ser Lys Val Phe Ser Gln 
            260                 265                 270         


Glu His Tyr Ala His Asp Arg Met Arg Glu Ala Arg Gln Ala Ala Ile 
        275                 280                 285             


Arg Ser Ala Ala Arg Ala Arg Cys Trp Gly Leu Leu Leu Gly Thr Leu 
    290                 295                 300                 


Gly Arg Gln Gly Ser Pro Ala Ile Leu Gln His Leu Glu Ser Arg Leu 
305                 310                 315                 320 


Arg Ala Leu Gly Arg Pro Phe Val Arg Val Leu Leu Ser Glu Ile Phe 
                325                 330                 335     


Pro Ser Lys Leu Gln Leu Phe Asp Ser Val Asp Ala Trp Val Gln Ile 
            340                 345                 350         


Ala Cys Pro Arg Leu Ser Ile Asp Trp Gly Glu Ala Phe Ser Lys Pro 
        355                 360                 365             


Leu Leu Thr Pro Tyr Glu Ala Ala Val Ala Leu Gly Asp Ile Glu Trp 
    370                 375                 380                 


Gln Gln Pro Tyr Pro Met Asp Phe Tyr Ala Ser Gln Ser Leu Gly Pro 
385                 390                 395                 400 


Trp Thr Ala Asn His Thr Ala Arg Pro Ala Gln Glu Lys Pro Pro Ala 
                405                 410                 415     


Thr Pro Ser Leu Lys Asn Gly Thr Glu Gly Ser Arg Ser Ala His Pro 
            420                 425                 430         


Pro Glu Asp Thr Ala Thr Ser 
        435                 


<210>  29
<211>  1377
<212>  DNA
<213>  Xenopus tropicalis

<400>  29
atgtcagaga tggcggaaga gccggttggg ttggagactg cgactgggac ggatcctcag       60

ctgggaatga tggctccggc gagaagccag tcagtagcac tgacacctgc ggctcccagt      120

aatgcaggcc gtgcacccat ccgtcgcgtg gctaaccaga tccctgatga aatctcccac      180

aatcctcttc tgctggaagc catgaaagtg ctgcccgaaa actacaattt tgaaataccc      240

aagacaatat ggagaattca gcaagcctca gccaaaagag ttgctttgca gatgccagaa      300

gggcttctca tgtttgcctg tactattgct gatatcatag aaaggttcac atcagcagag      360

acagtagtga tgggcgatgt gacgtatgga gcatgctgtg tggatgatta cactgcacaa      420

gcgctaggag ctgactttat ggtacattat ggacacagct gcctcatccc gattgatgcc      480

acgcatgggg tgcgtatgtt atatgttttt gtcgacataa agattgacac gtctcatttt      540

gtggacacca ttcgcttcaa ctttcaaccg ggagcatcac tagcgcttgt cagcacggtg      600

cagtttgtgt cagcacttca ggcagctcac caagccttac gtatggacta caaagtgact      660

gttccacagt gcaagccgct gtcacctgga gaaatcttag gttgcacctc tccaaagctg      720

gacaagtctg tggatgccgt agtgtatctg ggagatggac gctttcacct ggagtctgtt      780

atgatttcca accctgatac aaaagcttac aggtatgatc catacagcaa ggtattctct      840

cgggaatatt atgaccacag tgccatgctt aaacacagag gggaggccat ctcagctgct      900

gccggtgcaa aaacatgggg gcttatcctg ggtactctgg gtcgtcaggg atctcccaaa      960

atcctggagc acctggagtc acgtctgcag gcactcggct gtcgttacgt gcggctgctg     1020

ctgtcggaaa tcttccctaa taaactcaag ctgttcccag aggtggaagt gtgggtgcag     1080

gttgcctgcc caagactatc cattgattgg gggacagcat tctccaggcc tttgcttact     1140

ccatatgagg cctcagtggc tctgaaagaa gcagaatggc agcatactta tccaatggat     1200

ttctacgcca atgagtccct tggtccgtgg accgtgaacc atgaatccca ccgccccacc     1260

cgtgcaacag tccagcgcac acagaaatca gagcagagaa agcttcggag cacagacata     1320

agtgcaaagg ttgaagaatg cccctgtcag gataaaggag agaccaagac tgagtga        1377


<210>  30
<211>  458
<212>  PRT
<213>  Xenopus tropicalis

<400>  30

Met Ser Glu Met Ala Glu Glu Pro Val Gly Leu Glu Thr Ala Thr Gly 
1               5                   10                  15      


Thr Asp Pro Gln Leu Gly Met Met Ala Pro Ala Arg Ser Gln Ser Val 
            20                  25                  30          


Ala Leu Thr Pro Ala Ala Pro Ser Asn Ala Gly Arg Ala Pro Ile Arg 
        35                  40                  45              


Arg Val Ala Asn Gln Ile Pro Asp Glu Ile Ser His Asn Pro Leu Leu 
    50                  55                  60                  


Leu Glu Ala Met Lys Val Leu Pro Glu Asn Tyr Asn Phe Glu Ile Pro 
65                  70                  75                  80  


Lys Thr Ile Trp Arg Ile Gln Gln Ala Ser Ala Lys Arg Val Ala Leu 
                85                  90                  95      


Gln Met Pro Glu Gly Leu Leu Met Phe Ala Cys Thr Ile Ala Asp Ile 
            100                 105                 110         


Ile Glu Arg Phe Thr Ser Ala Glu Thr Val Val Met Gly Asp Val Thr 
        115                 120                 125             


Tyr Gly Ala Cys Cys Val Asp Asp Tyr Thr Ala Gln Ala Leu Gly Ala 
    130                 135                 140                 


Asp Phe Met Val His Tyr Gly His Ser Cys Leu Ile Pro Ile Asp Ala 
145                 150                 155                 160 


Thr His Gly Val Arg Met Leu Tyr Val Phe Val Asp Ile Lys Ile Asp 
                165                 170                 175     


Thr Ser His Phe Val Asp Thr Ile Arg Phe Asn Phe Gln Pro Gly Ala 
            180                 185                 190         


Ser Leu Ala Leu Val Ser Thr Val Gln Phe Val Ser Ala Leu Gln Ala 
        195                 200                 205             


Ala His Gln Ala Leu Arg Met Asp Tyr Lys Val Thr Val Pro Gln Cys 
    210                 215                 220                 


Lys Pro Leu Ser Pro Gly Glu Ile Leu Gly Cys Thr Ser Pro Lys Leu 
225                 230                 235                 240 


Asp Lys Ser Val Asp Ala Val Val Tyr Leu Gly Asp Gly Arg Phe His 
                245                 250                 255     


Leu Glu Ser Val Met Ile Ser Asn Pro Asp Thr Lys Ala Tyr Arg Tyr 
            260                 265                 270         


Asp Pro Tyr Ser Lys Val Phe Ser Arg Glu Tyr Tyr Asp His Ser Ala 
        275                 280                 285             


Met Leu Lys His Arg Gly Glu Ala Ile Ser Ala Ala Ala Gly Ala Lys 
    290                 295                 300                 


Thr Trp Gly Leu Ile Leu Gly Thr Leu Gly Arg Gln Gly Ser Pro Lys 
305                 310                 315                 320 


Ile Leu Glu His Leu Glu Ser Arg Leu Gln Ala Leu Gly Cys Arg Tyr 
                325                 330                 335     


Val Arg Leu Leu Leu Ser Glu Ile Phe Pro Asn Lys Leu Lys Leu Phe 
            340                 345                 350         


Pro Glu Val Glu Val Trp Val Gln Val Ala Cys Pro Arg Leu Ser Ile 
        355                 360                 365             


Asp Trp Gly Thr Ala Phe Ser Arg Pro Leu Leu Thr Pro Tyr Glu Ala 
    370                 375                 380                 


Ser Val Ala Leu Lys Glu Ala Glu Trp Gln His Thr Tyr Pro Met Asp 
385                 390                 395                 400 


Phe Tyr Ala Asn Glu Ser Leu Gly Pro Trp Thr Val Asn His Glu Ser 
                405                 410                 415     


His Arg Pro Thr Arg Ala Thr Val Gln Arg Thr Gln Lys Ser Glu Gln 
            420                 425                 430         


Arg Lys Leu Arg Ser Thr Asp Ile Ser Ala Lys Val Glu Glu Cys Pro 
        435                 440                 445             


Cys Gln Asp Lys Gly Glu Thr Lys Thr Glu 
    450                 455             


<210>  31
<211>  1470
<212>  DNA
<213>  Homo sapiens

<400>  31
atggagtcga tgtttagcag ccctgccgag gcggcgctgc agcgagagac cggggtgcca       60

ggactgctta ctcctcttcc ggacctggac ggagtgtacg agctggagcg agtcgctgga      120

tttgtccgcg acctggggtg tgaacgagtt gccttgcagt tccctgacca gctattggga      180

gatgctgtgg ctgtggctgc acgactggag gagacgacag ggtcaaagat gttcattctg      240

ggtgacacag cctacggcag ctgctgcgtg gatgtgctgg gtgctgagca agctggagct      300

caggctctca tacattttgg ccctgcctgc ttaagccctc cagcccgccc actgcccgtt      360

gccttcgtgc ttcgtcaacg ttctgtggcc ttggagctct gtgtcaaggc ctttgaggcc      420

cagaacccag accccaaagc gcctgtggtg ctgctgagtg agccggcctg tgcccatgcc      480

ctggaggctt tggctactct cctgcgccca cggtacctgg acctgctagt ctccagccca      540

gcttttcccc aaccagtggg ttccctgagt ccagagccta tgcccctaga gcgttttggg      600

cgccgcttcc cccttgcccc agggaggcgt ctagaagagt atggtgcctt ctatgtaggg      660

ggctctaagg ccagccctga cccagacctt gacccagacc tgagtcggct gctcttgggg      720

tgggcaccag gtcaaccctt ctcctcctgc tgtccagata cagggaagac tcaggatgag      780

ggtgcccggg ctggacggct aagggcacga agacgatatc tggtagagag ggccagagat      840

gcccgcgtgg tagggctgct ggcaggcaca ctgggtgtag cccaacaccg tgaggcactg      900

gcccacttgc ggaacctgac tcaggctgct ggcaagcgta gctatgtgtt ggccctgggg      960

cggcccaccc ctgccaagct tgccaacttc cctgaggtgg atgtctttgt gctattagcc     1020

tgtcctctgg gtgctctagc cccccagctt tctggtagct tcttccagcc tatactggca     1080

ccatgtgagc tggaagctgc ctgcaaccct gcctggccac ctccaggcct ggctccccac     1140

ctcacacatt atgcggactt attgcctggc tctcccttcc acgtggctct cccaccacct     1200

gagtcagagc tgtgggaaac cccagacgtg tcactcatta ctggagatct ccgaccccca     1260

cctgcctgga agtcatcaaa tgatcatgga agcttggctc tgaccccacg gccccagctg     1320

gagctggctg agagcagtcc tgcagcctca ttccttagtt cccggagctg gcaagggctg     1380

gagccccgcc tgggtcagac gccagtgaca gaagctgtga gtggaagacg agggattgcc     1440

atcgcctatg aggatgaggg aagcggctga                                      1470


<210>  32
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  32
atggagtcga tgtttagcag ccctgccgag gcggcgctgc agcgagagac cggggtgcca       60

ggactgctta ctcctcttcc ggacctggac ggagtgtacg agctggagcg agtcgctgga      120

tttgtccgcg acctggggtg tgaacgagtt gccttgcagt tccctgacca gctattggga      180

gatgctgtgg ctgtggctgc acgactggag gagacgacag ggtcaaagat gttcattctg      240

ggtgacacag cctacggcag ctgctgcgtg gatgtgctgg gtgctgagca agctggagct      300

caggctctca tacattttgg ccctgcctgc ttaagccctc cagcccgccc actgcccgtt      360

gccttcgtgc ttcgtcaacg ttctgtggcc ttggagctct gtgtcaaggc ctttgaggcc      420

cagaacccag accccaaagc gcctgtggtg ctgctgagtg agccggcctg tgcccatgcc      480

ctgggctctc ccttccacgt ggctctccca ccacctgagt cagagctgtg ggaaacccca      540

gacgtgtcac tcattactgg agatctccga cccccacctg cctggaagtc atcaaatgat      600

catggaagct tggctctgac cccacggccc cagctggagc tggctgagag cagtcctgca      660

gcctcattcc ttagttcccg gagctggcaa gggctggagc cccgcctggg tcagacgcca      720

gtgacagaag ctgtgagtgg aagacgaggg attgccatcg cctatgagga tgagggaagc      780

ggctga                                                                 786


<210>  33
<211>  1242
<212>  DNA
<213>  Homo sapiens

<400>  33
atgttcattc tgggtgacac agcctacggc agctgctgcg tggatgtgct gggtgctgag       60

caagctggag ctcaggctct catacatttt ggccctgcct gcttaagccc tccagcccgc      120

ccactgcccg ttgccttcgt gcttcgtcaa cgttctgtgg ccttggagct ctgtgtcaag      180

gcctttgagg cccagaaccc agaccccaaa gcgcctgtgg tgctgctgag tgagccggcc      240

tgtgcccatg ccctggaggc tttggctact ctcctgcgcc cacggtacct ggacctgcta      300

gtctccagcc cagcttttcc ccaaccagtg ggttccctga gtccagagcc tatgccccta      360

gagcgttttg ggcgccgctt cccccttgcc ccagggaggc gtctagaaga gtatggtgcc      420

ttctatgtag ggggctctaa ggccagccct gacccagacc ttgacccaga cctgagtcgg      480

ctgctcttgg ggtgggcacc aggtcaaccc ttctcctcct gctgtccaga tacagggaag      540

actcaggatg agggtgcccg ggctggacgg ctaagggcac gaagacgata tctggtagag      600

agggccagag atgcccgcgt ggtagggctg ctggcaggca cactgggtgt agcccaacac      660

cgtgaggcac tggcccactt gcggaacctg actcaggctg ctggcaagcg tagctatgtg      720

ttggccctgg ggcggcccac ccctgccaag cttgccaact tccctgaggt ggatgtcttt      780

gtgctattag cctgtcctct gggtgctcta gccccccagc tttctggtag cttcttccag      840

cctatactgg caccatgtga gctggaagct gcctgcaacc ctgcctggcc acctccaggc      900

ctggctcccc acctcacaca ttatgcggac ttattgcctg gctctccctt ccacgtggct      960

ctcccaccac ctgagtcaga gctgtgggaa accccagacg tgtcactcat tactggagat     1020

ctccgacccc cacctgcctg gaagtcatca aatgatcatg gaagcttggc tctgacccca     1080

cggccccagc tggagctggc tgagagcagt cctgcagcct cattccttag ttcccggagc     1140

tggcaagggc tggagccccg cctgggtcag acgccagtga cagaagctgt gagtggaaga     1200

cgagggattg ccatcgccta tgaggatgag ggaagcggct ga                        1242


<210>  34
<211>  1197
<212>  DNA
<213>  Homo sapiens

<400>  34
atggagtcga tgtttagcag ccctgccgag gcggcgctgc agcgagagac cggggtgcca       60

ggactgctta ctcctcttcc ggacctggac ggagtgtacg agctggagcg agtcgctgga      120

tttgtccgcg acctggggtg tgaacgagtt gccttgcagt tccctgacca gctattggga      180

gatgctgtgg ctgtggctgc acgactggag gagacgacag ggtcaaagat gttcattctg      240

ggtgacacag cctacggcag ctgctgcgtg gatgtgctgg gtgctgagca agctggagct      300

caggctctca tacattttgg ccctgcctgc ttaagccctc cagcccgccc actgcccgtt      360

gccttcgtgc ttcgtcaacg ttctgtggcc ttggagctct gtgtcaaggc ctttgaggcc      420

cagaacccag accccaaagc gcctgtggtg ctgctgagtg agccggcctg tgcccatgcc      480

ctggatacag ggaagactca ggatgagggt gcccgggctg gacggctaag ggcacgaaga      540

cgatatctgg tagagagggc cagagatgcc cgcgtggtag ggctgctggc aggcacactg      600

ggtgtagccc aacaccgtga ggcactggcc cacttgcgga acctgactca ggctgctggc      660

aagcgtagct atgtgttggc cctggggcgg cccacccctg ccaagcttgc caacttccct      720

gaggtggatg tctttgtgct attagcctgt cctctgggtg ctctagcccc ccagctttct      780

ggtagcttct tccagcctat actggcacca tgtgagctgg aagctgcctg caaccctgcc      840

tggccacctc caggcctggc tccccacctc acacattatg cggacttatt gcctggctct      900

cccttccacg tggctctccc accacctgag tcagagctgt gggaaacccc agacgtgtca      960

ctcattactg gagatctccg acccccacct gcctggaagt catcaaatga tcatggaagc     1020

ttggctctga ccccacggcc ccagctggag ctggctgaga gcagtcctgc agcctcattc     1080

cttagttccc ggagctggca agggctggag ccccgcctgg gtcagacgcc agtgacagaa     1140

gctgtgagtg gaagacgagg gattgccatc gcctatgagg atgagggaag cggctga        1197


<210>  35
<211>  891
<212>  DNA
<213>  Homo sapiens

<400>  35
atgcccctag agcgttttgg gcgccgcttc ccccttgccc cagggaggcg tctagaagag       60

tatggtgcct tctatgtagg gggctctaag gccagccctg acccagacct tgacccagac      120

ctgagtcggc tgctcttggg gtgggcacca ggtcaaccct tctcctcctg ctgtccagat      180

acagggaaga ctcaggatga gggtgcccgg gctggacggc taagggcacg aagacgatat      240

ctggtagaga gggccagaga tgcccgcgtg gtagggctgc tggcaggcac actgggtgta      300

gcccaacacc gtgaggcact ggcccacttg cggaacctga ctcaggctgc tggcaagcgt      360

agctatgtgt tggccctggg gcggcccacc cctgccaagc ttgccaactt ccctgaggtg      420

gatgtctttg tgctattagc ctgtcctctg ggtgctctag ccccccagct ttctggtagc      480

ttcttccagc ctatactggc accatgtgag ctggaagctg cctgcaaccc tgcctggcca      540

cctccaggcc tggctcccca cctcacacat tatgcggact tattgcctgg ctctcccttc      600

cacgtggctc tcccaccacc tgagtcagag ctgtgggaaa ccccagacgt gtcactcatt      660

actggagatc tccgaccccc acctgcctgg aagtcatcaa atgatcatgg aagcttggct      720

ctgaccccac ggccccagct ggagctggct gagagcagtc ctgcagcctc attccttagt      780

tcccggagct ggcaagggct ggagccccgc ctgggtcaga cgccagtgac agaagctgtg      840

agtggaagac gagggattgc catcgcctat gaggatgagg gaagcggctg a               891


<210>  36
<211>  1242
<212>  DNA
<213>  Homo sapiens

<400>  36
atgttcattc tgggtgacac agcctacggc agctgctgcg tggatgtgct gggtgctgag       60

caagctggag ctcaggctct catacatttt ggccctgcct gcttaagccc tccagcccgc      120

ccactgcccg ttgccttcgt gcttcgtcaa cgttctgtgg ccttggagct ctgtgtcaag      180

gcctttgagg cccagaaccc agaccccaaa gcgcctgtgg tgctgctgag tgagccggcc      240

tgtgcccatg ccctggaggc tttggctact ctcctgcgcc cacggtacct ggacctgcta      300

gtctccagcc cagcttttcc ccaaccagtg ggttccctga gtccagagcc tatgccccta      360

gagcgttttg ggcgccgctt cccccttgcc ccagggaggc gtctagaaga gtatggtgcc      420

ttctatgtag ggggctctaa ggccagccct gacccagacc ttgacccaga cctgagtcgg      480

ctgctcttgg ggtgggcacc aggtcaaccc ttctcctcct gctgtccaga tacagggaag      540

actcaggatg agggtgcccg ggctggacgg ctaagggcac gaagacgata tctggtagag      600

agggccagag atgcccgcgt ggtagggctg ctggcaggca cactgggtgt agcccaacac      660

cgtgaggcac tggcccactt gcggaacctg actcaggctg ctggcaagcg tagctatgtg      720

ttggccctgg ggcggcccac ccctgccaag cttgccaact tccctgaggt ggatgtcttt      780

gtgctattag cctgtcctct gggtgctcta gccccccagc tttctggtag cttcttccag      840

cctatactgg caccatgtga gctggaagct gcctgcaacc ctgcctggcc acctccaggc      900

ctggctcccc acctcacaca ttatgcggac ttattgcctg gctctccctt ccacgtggct      960

ctcccaccac ctgagtcaga gctgtgggaa accccagacg tgtcactcat tactggagat     1020

ctccgacccc cacctgcctg gaagtcatca aatgatcatg gaagcttggc tctgacccca     1080

cggccccagc tggagctggc tgagagcagt cctgcagcct cattccttag ttcccggagc     1140

tggcaagggc tggagccccg cctgggtcag acgccagtga cagaagctgt gagtggaaga     1200

cgagggattg ccatcgccta tgaggatgag ggaagcggct ga                        1242


<210>  37
<211>  1065
<212>  DNA
<213>  Homo sapiens

<400>  37
atgctgtggc tgtggctgca cgactggagg agacgacagg gtcaaagatg ttcattctgg       60

gtgacacagc ctacggcaga ggctttggct actctcctgc gcccacggta cctggacctg      120

ctagtctcca gcccagcttt tccccaacca gtgggttccc tgagtccaga gcctatgccc      180

ctagagcgtt ttgggcgccg cttccccctt gccccaggga ggcgtctaga agagtatggt      240

gccttctatg tagggggctc taaggccagc cctgacccag accttgaccc agacctgagt      300

cggctgctct tggggtgggc accaggtcaa cccttctcct cctgctgtcc agatacaggg      360

aagactcagg atgagggtgc ccgggctgga cggctaaggg cacgaagacg atatctggta      420

gagagggcca gagatgcccg cgtggtaggg ctgctggcag gcacactggg tgtagcccaa      480

caccgtgagg cactggccca cttgcggaac ctgactcagg ctgctggcaa gcgtagctat      540

gtgttggccc tggggcggcc cacccctgcc aagcttgcca acttccctga ggtggatgtc      600

tttgtgctat tagcctgtcc tctgggtgct ctagcccccc agctttctgg tagcttcttc      660

cagcctatac tggcaccatg tgagctggaa gctgcctgca accctgcctg gccacctcca      720

ggcctggctc cccacctcac acattatgcg gacttattgc ctggctctcc cttccacgtg      780

gctctcccac cacctgagtc agagctgtgg gaaaccccag acgtgtcact cattactgga      840

gatctccgac ccccacctgc ctggaagtca tcaaatgatc atggaagctt ggctctgacc      900

ccacggcccc agctggagct ggctgagagc agtcctgcag cctcattcct tagttcccgg      960

agctggcaag ggctggagcc ccgcctgggt cagacgccag tgacagaagc tgtgagtgga     1020

agacgaggga ttgccatcgc ctatgaggat gagggaagcg gctga                     1065


<210>  38
<211>  891
<212>  DNA
<213>  Homo sapiens

<400>  38
atgcccctag agcgttttgg gcgccgcttc ccccttgccc cagggaggcg tctagaagag       60

tatggtgcct tctatgtagg gggctctaag gccagccctg acccagacct tgacccagac      120

ctgagtcggc tgctcttggg gtgggcacca ggtcaaccct tctcctcctg ctgtccagat      180

acagggaaga ctcaggatga gggtgcccgg gctggacggc taagggcacg aagacgatat      240

ctggtagaga gggccagaga tgcccgcgtg gtagggctgc tggcaggcac actgggtgta      300

gcccaacacc gtgaggcact ggcccacttg cggaacctga ctcaggctgc tggcaagcgt      360

agctatgtgt tggccctggg gcggcccacc cctgccaagc ttgccaactt ccctgaggtg      420

gatgtctttg tgctattagc ctgtcctctg ggtgctctag ccccccagct ttctggtagc      480

ttcttccagc ctatactggc accatgtgag ctggaagctg cctgcaaccc tgcctggcca      540

cctccaggcc tggctcccca cctcacacat tatgcggact tattgcctgg ctctcccttc      600

cacgtggctc tcccaccacc tgagtcagag ctgtgggaaa ccccagacgt gtcactcatt      660

actggagatc tccgaccccc acctgcctgg aagtcatcaa atgatcatgg aagcttggct      720

ctgaccccac ggccccagct ggagctggct gagagcagtc ctgcagcctc attccttagt      780

tcccggagct ggcaagggct ggagccccgc ctgggtcaga cgccagtgac agaagctgtg      840

agtggaagac gagggattgc catcgcctat gaggatgagg gaagcggctg a               891


<210>  39
<211>  1026
<212>  DNA
<213>  Homo sapiens

<400>  39
atgccctggg taaggggttt tgcctgtgta tgcacaaagg aggctttggc tactctcctg       60

cgcccacggt acctggacct gctagtctcc agcccagctt ttccccaacc agtgggttcc      120

ctgagtccag agcctatgcc cctagagcgt tttgggcgcc gcttccccct tgccccaggg      180

aggcgtctag aagagtatgg tgccttctat gtagggggct ctaaggccag ccctgaccca      240

gaccttgacc cagacctgag tcggctgctc ttggggtggg caccaggtca acccttctcc      300

tcctgctgtc cagatacagg gaagactcag gatgagggtg cccgggctgg acggctaagg      360

gcacgaagac gatatctggt agagagggcc agagatgccc gcgtggtagg gctgctggca      420

ggcacactgg gtgtagccca acaccgtgag gcactggccc acttgcggaa cctgactcag      480

gctgctggca agcgtagcta tgtgttggcc ctggggcggc ccacccctgc caagcttgcc      540

aacttccctg aggtggatgt ctttgtgcta ttagcctgtc ctctgggtgc tctagccccc      600

cagctttctg gtagcttctt ccagcctata ctggcaccat gtgagctgga agctgcctgc      660

aaccctgcct ggccacctcc aggcctggct ccccacctca cacattatgc ggacttattg      720

cctggctctc ccttccacgt ggctctccca ccacctgagt cagagctgtg ggaaacccca      780

gacgtgtcac tcattactgg agatctccga cccccacctg cctggaagtc atcaaatgat      840

catggaagct tggctctgac cccacggccc cagctggagc tggctgagag cagtcctgca      900

gcctcattcc ttagttcccg gagctggcaa gggctggagc cccgcctggg tcagacgcca      960

gtgacagaag ctgtgagtgg aagacgaggg attgccatcg cctatgagga tgagggaagc     1020

ggctga                                                                1026


<210>  40
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Ser Met Phe Ser Ser Pro Ala Glu Ala Ala Leu Gln Arg Glu 
1               5                   10                  15      


Thr Gly Val Pro Gly Leu Leu Thr Pro Leu Pro Asp Leu Asp Gly Val 
            20                  25                  30          


Tyr Glu Leu Glu Arg Val Ala Gly Phe Val Arg Asp Leu Gly Cys Glu 
        35                  40                  45              


Arg Val Ala Leu Gln Phe Pro Asp Gln Leu Leu Gly Asp Ala Val Ala 
    50                  55                  60                  


Val Ala Ala Arg Leu Glu Glu Thr Thr Gly Ser Lys Met Phe Ile Leu 
65                  70                  75                  80  


Gly Asp Thr Ala Tyr Gly Ser Cys Cys Val Asp Val Leu Gly Ala Glu 
                85                  90                  95      


Gln Ala Gly Ala Gln Ala Leu Ile His Phe Gly Pro Ala Cys Leu Ser 
            100                 105                 110         


Pro Pro Ala Arg Pro Leu Pro Val Ala Phe Val Leu Arg Gln Arg Ser 
        115                 120                 125             


Val Ala Leu Glu Leu Cys Val Lys Ala Phe Glu Ala Gln Asn Pro Asp 
    130                 135                 140                 


Pro Lys Ala Pro Val Val Leu Leu Ser Glu Pro Ala Cys Ala His Ala 
145                 150                 155                 160 


Leu Glu Ala Leu Ala Thr Leu Leu Arg Pro Arg Tyr Leu Asp Leu Leu 
                165                 170                 175     


Val Ser Ser Pro Ala Phe Pro Gln Pro Val Gly Ser Leu Ser Pro Glu 
            180                 185                 190         


Pro Met Pro Leu Glu Arg Phe Gly Arg Arg Phe Pro Leu Ala Pro Gly 
        195                 200                 205             


Arg Arg Leu Glu Glu Tyr Gly Ala Phe Tyr Val Gly Gly Ser Lys Ala 
    210                 215                 220                 


Ser Pro Asp Pro Asp Leu Asp Pro Asp Leu Ser Arg Leu Leu Leu Gly 
225                 230                 235                 240 


Trp Ala Pro Gly Gln Pro Phe Ser Ser Cys Cys Pro Asp Thr Gly Lys 
                245                 250                 255     


Thr Gln Asp Glu Gly Ala Arg Ala Gly Arg Leu Arg Ala Arg Arg Arg 
            260                 265                 270         


Tyr Leu Val Glu Arg Ala Arg Asp Ala Arg Val Val Gly Leu Leu Ala 
        275                 280                 285             


Gly Thr Leu Gly Val Ala Gln His Arg Glu Ala Leu Ala His Leu Arg 
    290                 295                 300                 


Asn Leu Thr Gln Ala Ala Gly Lys Arg Ser Tyr Val Leu Ala Leu Gly 
305                 310                 315                 320 


Arg Pro Thr Pro Ala Lys Leu Ala Asn Phe Pro Glu Val Asp Val Phe 
                325                 330                 335     


Val Leu Leu Ala Cys Pro Leu Gly Ala Leu Ala Pro Gln Leu Ser Gly 
            340                 345                 350         


Ser Phe Phe Gln Pro Ile Leu Ala Pro Cys Glu Leu Glu Ala Ala Cys 
        355                 360                 365             


Asn Pro Ala Trp Pro Pro Pro Gly Leu Ala Pro His Leu Thr His Tyr 
    370                 375                 380                 


Ala Asp Leu Leu Pro Gly Ser Pro Phe His Val Ala Leu Pro Pro Pro 
385                 390                 395                 400 


Glu Ser Glu Leu Trp Glu Thr Pro Asp Val Ser Leu Ile Thr Gly Asp 
                405                 410                 415     


Leu Arg Pro Pro Pro Ala Trp Lys Ser Ser Asn Asp His Gly Ser Leu 
            420                 425                 430         


Ala Leu Thr Pro Arg Pro Gln Leu Glu Leu Ala Glu Ser Ser Pro Ala 
        435                 440                 445             


Ala Ser Phe Leu Ser Ser Arg Ser Trp Gln Gly Leu Glu Pro Arg Leu 
    450                 455                 460                 


Gly Gln Thr Pro Val Thr Glu Ala Val Ser Gly Arg Arg Gly Ile Ala 
465                 470                 475                 480 


Ile Ala Tyr Glu Asp Glu Gly Ser Gly 
                485                 


<210>  41
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Ser Met Phe Ser Ser Pro Ala Glu Ala Ala Leu Gln Arg Glu 
1               5                   10                  15      


Thr Gly Val Pro Gly Leu Leu Thr Pro Leu Pro Asp Leu Asp Gly Val 
            20                  25                  30          


Tyr Glu Leu Glu Arg Val Ala Gly Phe Val Arg Asp Leu Gly Cys Glu 
        35                  40                  45              


Arg Val Ala Leu Gln Phe Pro Asp Gln Leu Leu Gly Asp Ala Val Ala 
    50                  55                  60                  


Val Ala Ala Arg Leu Glu Glu Thr Thr Gly Ser Lys Met Phe Ile Leu 
65                  70                  75                  80  


Gly Asp Thr Ala Tyr Gly Ser Cys Cys Val Asp Val Leu Gly Ala Glu 
                85                  90                  95      


Gln Ala Gly Ala Gln Ala Leu Ile His Phe Gly Pro Ala Cys Leu Ser 
            100                 105                 110         


Pro Pro Ala Arg Pro Leu Pro Val Ala Phe Val Leu Arg Gln Arg Ser 
        115                 120                 125             


Val Ala Leu Glu Leu Cys Val Lys Ala Phe Glu Ala Gln Asn Pro Asp 
    130                 135                 140                 


Pro Lys Ala Pro Val Val Leu Leu Ser Glu Pro Ala Cys Ala His Ala 
145                 150                 155                 160 


Leu Gly Ser Pro Phe His Val Ala Leu Pro Pro Pro Glu Ser Glu Leu 
                165                 170                 175     


Trp Glu Thr Pro Asp Val Ser Leu Ile Thr Gly Asp Leu Arg Pro Pro 
            180                 185                 190         


Pro Ala Trp Lys Ser Ser Asn Asp His Gly Ser Leu Ala Leu Thr Pro 
        195                 200                 205             


Arg Pro Gln Leu Glu Leu Ala Glu Ser Ser Pro Ala Ala Ser Phe Leu 
    210                 215                 220                 


Ser Ser Arg Ser Trp Gln Gly Leu Glu Pro Arg Leu Gly Gln Thr Pro 
225                 230                 235                 240 


Val Thr Glu Ala Val Ser Gly Arg Arg Gly Ile Ala Ile Ala Tyr Glu 
                245                 250                 255     


Asp Glu Gly Ser Gly 
            260     


<210>  42
<211>  413
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Phe Ile Leu Gly Asp Thr Ala Tyr Gly Ser Cys Cys Val Asp Val 
1               5                   10                  15      


Leu Gly Ala Glu Gln Ala Gly Ala Gln Ala Leu Ile His Phe Gly Pro 
            20                  25                  30          


Ala Cys Leu Ser Pro Pro Ala Arg Pro Leu Pro Val Ala Phe Val Leu 
        35                  40                  45              


Arg Gln Arg Ser Val Ala Leu Glu Leu Cys Val Lys Ala Phe Glu Ala 
    50                  55                  60                  


Gln Asn Pro Asp Pro Lys Ala Pro Val Val Leu Leu Ser Glu Pro Ala 
65                  70                  75                  80  


Cys Ala His Ala Leu Glu Ala Leu Ala Thr Leu Leu Arg Pro Arg Tyr 
                85                  90                  95      


Leu Asp Leu Leu Val Ser Ser Pro Ala Phe Pro Gln Pro Val Gly Ser 
            100                 105                 110         


Leu Ser Pro Glu Pro Met Pro Leu Glu Arg Phe Gly Arg Arg Phe Pro 
        115                 120                 125             


Leu Ala Pro Gly Arg Arg Leu Glu Glu Tyr Gly Ala Phe Tyr Val Gly 
    130                 135                 140                 


Gly Ser Lys Ala Ser Pro Asp Pro Asp Leu Asp Pro Asp Leu Ser Arg 
145                 150                 155                 160 


Leu Leu Leu Gly Trp Ala Pro Gly Gln Pro Phe Ser Ser Cys Cys Pro 
                165                 170                 175     


Asp Thr Gly Lys Thr Gln Asp Glu Gly Ala Arg Ala Gly Arg Leu Arg 
            180                 185                 190         


Ala Arg Arg Arg Tyr Leu Val Glu Arg Ala Arg Asp Ala Arg Val Val 
        195                 200                 205             


Gly Leu Leu Ala Gly Thr Leu Gly Val Ala Gln His Arg Glu Ala Leu 
    210                 215                 220                 


Ala His Leu Arg Asn Leu Thr Gln Ala Ala Gly Lys Arg Ser Tyr Val 
225                 230                 235                 240 


Leu Ala Leu Gly Arg Pro Thr Pro Ala Lys Leu Ala Asn Phe Pro Glu 
                245                 250                 255     


Val Asp Val Phe Val Leu Leu Ala Cys Pro Leu Gly Ala Leu Ala Pro 
            260                 265                 270         


Gln Leu Ser Gly Ser Phe Phe Gln Pro Ile Leu Ala Pro Cys Glu Leu 
        275                 280                 285             


Glu Ala Ala Cys Asn Pro Ala Trp Pro Pro Pro Gly Leu Ala Pro His 
    290                 295                 300                 


Leu Thr His Tyr Ala Asp Leu Leu Pro Gly Ser Pro Phe His Val Ala 
305                 310                 315                 320 


Leu Pro Pro Pro Glu Ser Glu Leu Trp Glu Thr Pro Asp Val Ser Leu 
                325                 330                 335     


Ile Thr Gly Asp Leu Arg Pro Pro Pro Ala Trp Lys Ser Ser Asn Asp 
            340                 345                 350         


His Gly Ser Leu Ala Leu Thr Pro Arg Pro Gln Leu Glu Leu Ala Glu 
        355                 360                 365             


Ser Ser Pro Ala Ala Ser Phe Leu Ser Ser Arg Ser Trp Gln Gly Leu 
    370                 375                 380                 


Glu Pro Arg Leu Gly Gln Thr Pro Val Thr Glu Ala Val Ser Gly Arg 
385                 390                 395                 400 


Arg Gly Ile Ala Ile Ala Tyr Glu Asp Glu Gly Ser Gly 
                405                 410             


<210>  43
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Ser Met Phe Ser Ser Pro Ala Glu Ala Ala Leu Gln Arg Glu 
1               5                   10                  15      


Thr Gly Val Pro Gly Leu Leu Thr Pro Leu Pro Asp Leu Asp Gly Val 
            20                  25                  30          


Tyr Glu Leu Glu Arg Val Ala Gly Phe Val Arg Asp Leu Gly Cys Glu 
        35                  40                  45              


Arg Val Ala Leu Gln Phe Pro Asp Gln Leu Leu Gly Asp Ala Val Ala 
    50                  55                  60                  


Val Ala Ala Arg Leu Glu Glu Thr Thr Gly Ser Lys Met Phe Ile Leu 
65                  70                  75                  80  


Gly Asp Thr Ala Tyr Gly Ser Cys Cys Val Asp Val Leu Gly Ala Glu 
                85                  90                  95      


Gln Ala Gly Ala Gln Ala Leu Ile His Phe Gly Pro Ala Cys Leu Ser 
            100                 105                 110         


Pro Pro Ala Arg Pro Leu Pro Val Ala Phe Val Leu Arg Gln Arg Ser 
        115                 120                 125             


Val Ala Leu Glu Leu Cys Val Lys Ala Phe Glu Ala Gln Asn Pro Asp 
    130                 135                 140                 


Pro Lys Ala Pro Val Val Leu Leu Ser Glu Pro Ala Cys Ala His Ala 
145                 150                 155                 160 


Leu Asp Thr Gly Lys Thr Gln Asp Glu Gly Ala Arg Ala Gly Arg Leu 
                165                 170                 175     


Arg Ala Arg Arg Arg Tyr Leu Val Glu Arg Ala Arg Asp Ala Arg Val 
            180                 185                 190         


Val Gly Leu Leu Ala Gly Thr Leu Gly Val Ala Gln His Arg Glu Ala 
        195                 200                 205             


Leu Ala His Leu Arg Asn Leu Thr Gln Ala Ala Gly Lys Arg Ser Tyr 
    210                 215                 220                 


Val Leu Ala Leu Gly Arg Pro Thr Pro Ala Lys Leu Ala Asn Phe Pro 
225                 230                 235                 240 


Glu Val Asp Val Phe Val Leu Leu Ala Cys Pro Leu Gly Ala Leu Ala 
                245                 250                 255     


Pro Gln Leu Ser Gly Ser Phe Phe Gln Pro Ile Leu Ala Pro Cys Glu 
            260                 265                 270         


Leu Glu Ala Ala Cys Asn Pro Ala Trp Pro Pro Pro Gly Leu Ala Pro 
        275                 280                 285             


His Leu Thr His Tyr Ala Asp Leu Leu Pro Gly Ser Pro Phe His Val 
    290                 295                 300                 


Ala Leu Pro Pro Pro Glu Ser Glu Leu Trp Glu Thr Pro Asp Val Ser 
305                 310                 315                 320 


Leu Ile Thr Gly Asp Leu Arg Pro Pro Pro Ala Trp Lys Ser Ser Asn 
                325                 330                 335     


Asp His Gly Ser Leu Ala Leu Thr Pro Arg Pro Gln Leu Glu Leu Ala 
            340                 345                 350         


Glu Ser Ser Pro Ala Ala Ser Phe Leu Ser Ser Arg Ser Trp Gln Gly 
        355                 360                 365             


Leu Glu Pro Arg Leu Gly Gln Thr Pro Val Thr Glu Ala Val Ser Gly 
    370                 375                 380                 


Arg Arg Gly Ile Ala Ile Ala Tyr Glu Asp Glu Gly Ser Gly 
385                 390                 395             


<210>  44
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Pro Leu Glu Arg Phe Gly Arg Arg Phe Pro Leu Ala Pro Gly Arg 
1               5                   10                  15      


Arg Leu Glu Glu Tyr Gly Ala Phe Tyr Val Gly Gly Ser Lys Ala Ser 
            20                  25                  30          


Pro Asp Pro Asp Leu Asp Pro Asp Leu Ser Arg Leu Leu Leu Gly Trp 
        35                  40                  45              


Ala Pro Gly Gln Pro Phe Ser Ser Cys Cys Pro Asp Thr Gly Lys Thr 
    50                  55                  60                  


Gln Asp Glu Gly Ala Arg Ala Gly Arg Leu Arg Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Leu Val Glu Arg Ala Arg Asp Ala Arg Val Val Gly Leu Leu Ala Gly 
                85                  90                  95      


Thr Leu Gly Val Ala Gln His Arg Glu Ala Leu Ala His Leu Arg Asn 
            100                 105                 110         


Leu Thr Gln Ala Ala Gly Lys Arg Ser Tyr Val Leu Ala Leu Gly Arg 
        115                 120                 125             


Pro Thr Pro Ala Lys Leu Ala Asn Phe Pro Glu Val Asp Val Phe Val 
    130                 135                 140                 


Leu Leu Ala Cys Pro Leu Gly Ala Leu Ala Pro Gln Leu Ser Gly Ser 
145                 150                 155                 160 


Phe Phe Gln Pro Ile Leu Ala Pro Cys Glu Leu Glu Ala Ala Cys Asn 
                165                 170                 175     


Pro Ala Trp Pro Pro Pro Gly Leu Ala Pro His Leu Thr His Tyr Ala 
            180                 185                 190         


Asp Leu Leu Pro Gly Ser Pro Phe His Val Ala Leu Pro Pro Pro Glu 
        195                 200                 205             


Ser Glu Leu Trp Glu Thr Pro Asp Val Ser Leu Ile Thr Gly Asp Leu 
    210                 215                 220                 


Arg Pro Pro Pro Ala Trp Lys Ser Ser Asn Asp His Gly Ser Leu Ala 
225                 230                 235                 240 


Leu Thr Pro Arg Pro Gln Leu Glu Leu Ala Glu Ser Ser Pro Ala Ala 
                245                 250                 255     


Ser Phe Leu Ser Ser Arg Ser Trp Gln Gly Leu Glu Pro Arg Leu Gly 
            260                 265                 270         


Gln Thr Pro Val Thr Glu Ala Val Ser Gly Arg Arg Gly Ile Ala Ile 
        275                 280                 285             


Ala Tyr Glu Asp Glu Gly Ser Gly 
    290                 295     


<210>  45
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Leu Trp Leu Trp Leu His Asp Trp Arg Arg Arg Gln Gly Gln Arg 
1               5                   10                  15      


Cys Ser Phe Trp Val Thr Gln Pro Thr Ala Glu Ala Leu Ala Thr Leu 
            20                  25                  30          


Leu Arg Pro Arg Tyr Leu Asp Leu Leu Val Ser Ser Pro Ala Phe Pro 
        35                  40                  45              


Gln Pro Val Gly Ser Leu Ser Pro Glu Pro Met Pro Leu Glu Arg Phe 
    50                  55                  60                  


Gly Arg Arg Phe Pro Leu Ala Pro Gly Arg Arg Leu Glu Glu Tyr Gly 
65                  70                  75                  80  


Ala Phe Tyr Val Gly Gly Ser Lys Ala Ser Pro Asp Pro Asp Leu Asp 
                85                  90                  95      


Pro Asp Leu Ser Arg Leu Leu Leu Gly Trp Ala Pro Gly Gln Pro Phe 
            100                 105                 110         


Ser Ser Cys Cys Pro Asp Thr Gly Lys Thr Gln Asp Glu Gly Ala Arg 
        115                 120                 125             


Ala Gly Arg Leu Arg Ala Arg Arg Arg Tyr Leu Val Glu Arg Ala Arg 
    130                 135                 140                 


Asp Ala Arg Val Val Gly Leu Leu Ala Gly Thr Leu Gly Val Ala Gln 
145                 150                 155                 160 


His Arg Glu Ala Leu Ala His Leu Arg Asn Leu Thr Gln Ala Ala Gly 
                165                 170                 175     


Lys Arg Ser Tyr Val Leu Ala Leu Gly Arg Pro Thr Pro Ala Lys Leu 
            180                 185                 190         


Ala Asn Phe Pro Glu Val Asp Val Phe Val Leu Leu Ala Cys Pro Leu 
        195                 200                 205             


Gly Ala Leu Ala Pro Gln Leu Ser Gly Ser Phe Phe Gln Pro Ile Leu 
    210                 215                 220                 


Ala Pro Cys Glu Leu Glu Ala Ala Cys Asn Pro Ala Trp Pro Pro Pro 
225                 230                 235                 240 


Gly Leu Ala Pro His Leu Thr His Tyr Ala Asp Leu Leu Pro Gly Ser 
                245                 250                 255     


Pro Phe His Val Ala Leu Pro Pro Pro Glu Ser Glu Leu Trp Glu Thr 
            260                 265                 270         


Pro Asp Val Ser Leu Ile Thr Gly Asp Leu Arg Pro Pro Pro Ala Trp 
        275                 280                 285             


Lys Ser Ser Asn Asp His Gly Ser Leu Ala Leu Thr Pro Arg Pro Gln 
    290                 295                 300                 


Leu Glu Leu Ala Glu Ser Ser Pro Ala Ala Ser Phe Leu Ser Ser Arg 
305                 310                 315                 320 


Ser Trp Gln Gly Leu Glu Pro Arg Leu Gly Gln Thr Pro Val Thr Glu 
                325                 330                 335     


Ala Val Ser Gly Arg Arg Gly Ile Ala Ile Ala Tyr Glu Asp Glu Gly 
            340                 345                 350         


Ser Gly 
        


<210>  46
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Pro Trp Val Arg Gly Phe Ala Cys Val Cys Thr Lys Glu Ala Leu 
1               5                   10                  15      


Ala Thr Leu Leu Arg Pro Arg Tyr Leu Asp Leu Leu Val Ser Ser Pro 
            20                  25                  30          


Ala Phe Pro Gln Pro Val Gly Ser Leu Ser Pro Glu Pro Met Pro Leu 
        35                  40                  45              


Glu Arg Phe Gly Arg Arg Phe Pro Leu Ala Pro Gly Arg Arg Leu Glu 
    50                  55                  60                  


Glu Tyr Gly Ala Phe Tyr Val Gly Gly Ser Lys Ala Ser Pro Asp Pro 
65                  70                  75                  80  


Asp Leu Asp Pro Asp Leu Ser Arg Leu Leu Leu Gly Trp Ala Pro Gly 
                85                  90                  95      


Gln Pro Phe Ser Ser Cys Cys Pro Asp Thr Gly Lys Thr Gln Asp Glu 
            100                 105                 110         


Gly Ala Arg Ala Gly Arg Leu Arg Ala Arg Arg Arg Tyr Leu Val Glu 
        115                 120                 125             


Arg Ala Arg Asp Ala Arg Val Val Gly Leu Leu Ala Gly Thr Leu Gly 
    130                 135                 140                 


Val Ala Gln His Arg Glu Ala Leu Ala His Leu Arg Asn Leu Thr Gln 
145                 150                 155                 160 


Ala Ala Gly Lys Arg Ser Tyr Val Leu Ala Leu Gly Arg Pro Thr Pro 
                165                 170                 175     


Ala Lys Leu Ala Asn Phe Pro Glu Val Asp Val Phe Val Leu Leu Ala 
            180                 185                 190         


Cys Pro Leu Gly Ala Leu Ala Pro Gln Leu Ser Gly Ser Phe Phe Gln 
        195                 200                 205             


Pro Ile Leu Ala Pro Cys Glu Leu Glu Ala Ala Cys Asn Pro Ala Trp 
    210                 215                 220                 


Pro Pro Pro Gly Leu Ala Pro His Leu Thr His Tyr Ala Asp Leu Leu 
225                 230                 235                 240 


Pro Gly Ser Pro Phe His Val Ala Leu Pro Pro Pro Glu Ser Glu Leu 
                245                 250                 255     


Trp Glu Thr Pro Asp Val Ser Leu Ile Thr Gly Asp Leu Arg Pro Pro 
            260                 265                 270         


Pro Ala Trp Lys Ser Ser Asn Asp His Gly Ser Leu Ala Leu Thr Pro 
        275                 280                 285             


Arg Pro Gln Leu Glu Leu Ala Glu Ser Ser Pro Ala Ala Ser Phe Leu 
    290                 295                 300                 


Ser Ser Arg Ser Trp Gln Gly Leu Glu Pro Arg Leu Gly Gln Thr Pro 
305                 310                 315                 320 


Val Thr Glu Ala Val Ser Gly Arg Arg Gly Ile Ala Ile Ala Tyr Glu 
                325                 330                 335     


Asp Glu Gly Ser Gly 
            340     


<210>  47
<211>  1470
<212>  DNA
<213>  Mus musculus

<400>  47
atggagtcta cgttcagcag ccctgcggag gcagccctgc aacgggaggc gggcgttcca       60

ggacagttca ctcctcctga agacctggac cgcgtgtatg agctggagcg agttacgaaa      120

tttgtctgcg atttaggttg tcagcgggtg actttgcagt tccctgacca gttactagga      180

gatgcgggag cggtggctgc ccggctggag gaagtcacag gagctaagat gttcatttta      240

ggggacacag cttatggcag ctgctgtgtg gatgtgctgg gcgccgagca ggctggagct      300

caagcccttg tgcacttcgg tcctgcctgc ttaagccccc cagcctcgca gctgcccatc      360

acctttgtcc ttggtcagcg acccgttgct ttagagctct gtgcaaaggc ctttgaagcc      420

cagaacccag atccgacagc cccggtggta ctgctgagtg agccagcttg tgcccatgcc      480

ctagagcctt tggccatgct cctgctccca aagtaccaag atctgctcat ctcccgccca      540

gctcttcccc tgccagtggg atccccgagc tcacagcctg agtccctgga gcgttttggg      600

cgctgcttcc ccctgaatcc agggagacgt ctggaagaat atggtgcctt ctatgtaggg      660

gcttctcaag caagctcgga ctccagcctt gatcccgacc tgagcagact gctcttgggt      720

tggacaccag ggcggccctt cttttcctgt tgtccagata caggacagac acaagaccag      780

ggtgccaagg ctgggagact aagagcacga agactgtatc tcatagagag ggccagagat      840

gcccgtgtgg ttgggctgct ggcaggcaca ttaggtgtgg ctcgacaccg tgaggcactg      900

gcacacttgc ggaaactgac ggaagctgct ggaaaacgta gctatgtgtt agccgtgggg      960

aagcccacac ccgccaagct tgccaacttc cctgagatgg acgtctttgt gctgttagcc     1020

tgtcccctgg gggcactagc cccccagcct tcgggtggct tctttcggcc tgtattgacg     1080

ccatgtgaat tggaggctgc ctgcaaccct gcctggcccc cgccaggcct ggctccccac     1140

ctcacacatt atgcagagct gttgcctggt tctcccttcc atgtgccact ccctccacct     1200

gagtcagagt tgtgggatac cccagatgtg tcactcattt ctggggagct ccgaccacca     1260

cctccttgga agtcatcaga tgacactaga tgttcggcct taattccgag gccccaactg     1320

gagctggcgg agagcagccc tgcagcttca ttccttagtt ctcggaactg gcaggggctg     1380

gagccacgct tgggccagac accagtgaaa gaagccgtca gaggaagacg aggtatcgcc     1440

atcgcctacg aggatgaggg gagcagctga                                      1470


<210>  48
<211>  489
<212>  PRT
<213>  Mus musculus

<400>  48

Met Glu Ser Thr Phe Ser Ser Pro Ala Glu Ala Ala Leu Gln Arg Glu 
1               5                   10                  15      


Ala Gly Val Pro Gly Gln Phe Thr Pro Pro Glu Asp Leu Asp Arg Val 
            20                  25                  30          


Tyr Glu Leu Glu Arg Val Thr Lys Phe Val Cys Asp Leu Gly Cys Gln 
        35                  40                  45              


Arg Val Thr Leu Gln Phe Pro Asp Gln Leu Leu Gly Asp Ala Gly Ala 
    50                  55                  60                  


Val Ala Ala Arg Leu Glu Glu Val Thr Gly Ala Lys Met Phe Ile Leu 
65                  70                  75                  80  


Gly Asp Thr Ala Tyr Gly Ser Cys Cys Val Asp Val Leu Gly Ala Glu 
                85                  90                  95      


Gln Ala Gly Ala Gln Ala Leu Val His Phe Gly Pro Ala Cys Leu Ser 
            100                 105                 110         


Pro Pro Ala Ser Gln Leu Pro Ile Thr Phe Val Leu Gly Gln Arg Pro 
        115                 120                 125             


Val Ala Leu Glu Leu Cys Ala Lys Ala Phe Glu Ala Gln Asn Pro Asp 
    130                 135                 140                 


Pro Thr Ala Pro Val Val Leu Leu Ser Glu Pro Ala Cys Ala His Ala 
145                 150                 155                 160 


Leu Glu Pro Leu Ala Met Leu Leu Leu Pro Lys Tyr Gln Asp Leu Leu 
                165                 170                 175     


Ile Ser Arg Pro Ala Leu Pro Leu Pro Val Gly Ser Pro Ser Ser Gln 
            180                 185                 190         


Pro Glu Ser Leu Glu Arg Phe Gly Arg Cys Phe Pro Leu Asn Pro Gly 
        195                 200                 205             


Arg Arg Leu Glu Glu Tyr Gly Ala Phe Tyr Val Gly Ala Ser Gln Ala 
    210                 215                 220                 


Ser Ser Asp Ser Ser Leu Asp Pro Asp Leu Ser Arg Leu Leu Leu Gly 
225                 230                 235                 240 


Trp Thr Pro Gly Arg Pro Phe Phe Ser Cys Cys Pro Asp Thr Gly Gln 
                245                 250                 255     


Thr Gln Asp Gln Gly Ala Lys Ala Gly Arg Leu Arg Ala Arg Arg Leu 
            260                 265                 270         


Tyr Leu Ile Glu Arg Ala Arg Asp Ala Arg Val Val Gly Leu Leu Ala 
        275                 280                 285             


Gly Thr Leu Gly Val Ala Arg His Arg Glu Ala Leu Ala His Leu Arg 
    290                 295                 300                 


Lys Leu Thr Glu Ala Ala Gly Lys Arg Ser Tyr Val Leu Ala Val Gly 
305                 310                 315                 320 


Lys Pro Thr Pro Ala Lys Leu Ala Asn Phe Pro Glu Met Asp Val Phe 
                325                 330                 335     


Val Leu Leu Ala Cys Pro Leu Gly Ala Leu Ala Pro Gln Pro Ser Gly 
            340                 345                 350         


Gly Phe Phe Arg Pro Val Leu Thr Pro Cys Glu Leu Glu Ala Ala Cys 
        355                 360                 365             


Asn Pro Ala Trp Pro Pro Pro Gly Leu Ala Pro His Leu Thr His Tyr 
    370                 375                 380                 


Ala Glu Leu Leu Pro Gly Ser Pro Phe His Val Pro Leu Pro Pro Pro 
385                 390                 395                 400 


Glu Ser Glu Leu Trp Asp Thr Pro Asp Val Ser Leu Ile Ser Gly Glu 
                405                 410                 415     


Leu Arg Pro Pro Pro Pro Trp Lys Ser Ser Asp Asp Thr Arg Cys Ser 
            420                 425                 430         


Ala Leu Ile Pro Arg Pro Gln Leu Glu Leu Ala Glu Ser Ser Pro Ala 
        435                 440                 445             


Ala Ser Phe Leu Ser Ser Arg Asn Trp Gln Gly Leu Glu Pro Arg Leu 
    450                 455                 460                 


Gly Gln Thr Pro Val Lys Glu Ala Val Arg Gly Arg Arg Gly Ile Ala 
465                 470                 475                 480 


Ile Ala Tyr Glu Asp Glu Gly Ser Ser 
                485                 


<210>  49
<211>  249
<212>  DNA
<213>  Homo sapiens

<400>  49
atggcagtgt ttcatgacga ggtggaaatc gaggacttcc aatatgacga ggactcggag       60

acgtatttct atccctgccc atgtggagat aacttctcca tcaccaagga agatttggag      120

aatggggaag acgtggcaac gtgtcctagc tgctctctca ttataaaagt gatttatgac      180

aaagatcagt ttgtgtgtgg agaaacagtc ccagcccctt cagccaacaa agaattagtt      240

aaatgctga                                                              249


<210>  50
<211>  174
<212>  DNA
<213>  Homo sapiens

<400>  50
atggcagtgt ttcatgacga ggtggaaatc gaggacttcc aatatgacga ggactcggag       60

acgtatttct atccctgccc atgtggagat aacttctcca tcaccaagga tcagtttgtg      120

tgtggagaaa cagtcccagc cccttcagcc aacaaagaat tagttaaatg ctga            174


<210>  51
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp 
1               5                   10                  15      


Glu Asp Ser Glu Thr Tyr Phe Tyr Pro Cys Pro Cys Gly Asp Asn Phe 
            20                  25                  30          


Ser Ile Thr Lys Glu Asp Leu Glu Asn Gly Glu Asp Val Ala Thr Cys 
        35                  40                  45              


Pro Ser Cys Ser Leu Ile Ile Lys Val Ile Tyr Asp Lys Asp Gln Phe 
    50                  55                  60                  


Val Cys Gly Glu Thr Val Pro Ala Pro Ser Ala Asn Lys Glu Leu Val 
65                  70                  75                  80  


Lys Cys 
        


<210>  52
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp 
1               5                   10                  15      


Glu Asp Ser Glu Thr Tyr Phe Tyr Pro Cys Pro Cys Gly Asp Asn Phe 
            20                  25                  30          


Ser Ile Thr Lys Asp Gln Phe Val Cys Gly Glu Thr Val Pro Ala Pro 
        35                  40                  45              


Ser Ala Asn Lys Glu Leu Val Lys Cys 
    50                  55          


<210>  53
<211>  249
<212>  DNA
<213>  Mus musculus

<400>  53
atggcggtgt ttcacgacga ggtggagatc gaggactttc aatatgacga ggactcggag       60

acatatttct acccttgccc ctgtggggat aactttgcca tcaccaagga agatttggaa      120

aatggagaag atgtggccac gtgtcctagc tgctcactca ttataaaagt gatttatgac      180

aaagatcagt tcatgtgtgg agaaacagtc ccagcacctt caaccaacaa ggagttagtt      240

aaatgctga                                                              249


<210>  54
<211>  174
<212>  DNA
<213>  Mus musculus

<400>  54
atggcggtgt ttcacgacga ggtggagatc gaggactttc aatatgacga ggactcggag       60

acatatttct acccttgccc ctgtggggat aactttgcca tcaccaagga tcagttcatg      120

tgtggagaaa cagtcccagc accttcaacc aacaaggagt tagttaaatg ctga            174


<210>  55
<211>  249
<212>  DNA
<213>  Mus musculus

<400>  55
atggcggtgt ttcacgacga ggtggagatc gaggactttc aatatgacga ggactcggag       60

acatatttct acccttgccc ctgtggggat aactttgcca tcaccaagga agatttggaa      120

aatggagaag atgtggccac gtgtcctagc tgctcactca ttataaaagt gatttatgac      180

aaagatcagt tcatgtgtgg agaaacagtc ccagcacctt caaccaacaa ggagttagtt      240

aaatgctga                                                              249


<210>  56
<211>  82
<212>  PRT
<213>  Mus musculus

<400>  56

Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp 
1               5                   10                  15      


Glu Asp Ser Glu Thr Tyr Phe Tyr Pro Cys Pro Cys Gly Asp Asn Phe 
            20                  25                  30          


Ala Ile Thr Lys Glu Asp Leu Glu Asn Gly Glu Asp Val Ala Thr Cys 
        35                  40                  45              


Pro Ser Cys Ser Leu Ile Ile Lys Val Ile Tyr Asp Lys Asp Gln Phe 
    50                  55                  60                  


Met Cys Gly Glu Thr Val Pro Ala Pro Ser Thr Asn Lys Glu Leu Val 
65                  70                  75                  80  


Lys Cys 
        


<210>  57
<211>  57
<212>  PRT
<213>  Mus musculus

<400>  57

Met Ala Val Phe His Asp Glu Val Glu Ile Glu Asp Phe Gln Tyr Asp 
1               5                   10                  15      


Glu Asp Ser Glu Thr Tyr Phe Tyr Pro Cys Pro Cys Gly Asp Asn Phe 
            20                  25                  30          


Ala Ile Thr Lys Asp Gln Phe Met Cys Gly Glu Thr Val Pro Ala Pro 
        35                  40                  45              


Ser Thr Asn Lys Glu Leu Val Lys Cys 
    50                  55          


<210>  58
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  58
atgatggcgg ttgagcagat gccaaaaaag gattggtaca gcatcctggg agcagaccca       60

tctgcaaata tatcagacct aaaacaaaaa tatcaaaaac tcatattaat gtatcatcca      120

gataaacaaa gtacagatgt accagcagga acagtggagg aatgtgtaca gaagttcatc      180

gaaattgatc aagcatggaa aattctagga aatgaagaga caaaaagaga gtatgacctg      240

cagcggtgtg aagatgatct aagaaatgta ggaccagtag atgctcaagt atatcttgaa      300

gaaatgtctt ggaatgaagg tgatcactct ttttatctga gttgcagatg tggtggaaaa      360

tacagtgttt ccaaggatga agcggaagaa gttagcctga tttcttgtga tacatgttca      420

ctaattatag aactccttca ttataactaa                                       450


<210>  59
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Met Ala Val Glu Gln Met Pro Lys Lys Asp Trp Tyr Ser Ile Leu 
1               5                   10                  15      


Gly Ala Asp Pro Ser Ala Asn Ile Ser Asp Leu Lys Gln Lys Tyr Gln 
            20                  25                  30          


Lys Leu Ile Leu Met Tyr His Pro Asp Lys Gln Ser Thr Asp Val Pro 
        35                  40                  45              


Ala Gly Thr Val Glu Glu Cys Val Gln Lys Phe Ile Glu Ile Asp Gln 
    50                  55                  60                  


Ala Trp Lys Ile Leu Gly Asn Glu Glu Thr Lys Arg Glu Tyr Asp Leu 
65                  70                  75                  80  


Gln Arg Cys Glu Asp Asp Leu Arg Asn Val Gly Pro Val Asp Ala Gln 
                85                  90                  95      


Val Tyr Leu Glu Glu Met Ser Trp Asn Glu Gly Asp His Ser Phe Tyr 
            100                 105                 110         


Leu Ser Cys Arg Cys Gly Gly Lys Tyr Ser Val Ser Lys Asp Glu Ala 
        115                 120                 125             


Glu Glu Val Ser Leu Ile Ser Cys Asp Thr Cys Ser Leu Ile Ile Glu 
    130                 135                 140                 


Leu Leu His Tyr Asn 
145                 


<210>  60
<211>  447
<212>  DNA
<213>  Mus musculus

<400>  60
atggctttgg agcagacact caaaaaggat tggtacagca ttctgggtgc agacccatct       60

gcaaatatgt cagacctaaa acaaaaatat cagaaactca tattactgta tcatccagat      120

aaacaaagtg cagatgtgcc agctggaacc atggaggagt gtatgcagaa gtttattgaa      180

attgatcagg catggaaaat tctagggaat gaagaaacca agaaaaagta tgacctgcag      240

cggcatgaag atgagctaag aaatgtgggg ccagtagatg cacaggtgcg ccttgaagag      300

atgtcctgga accaaggtga tgaatctttc tttctgagct gtcgatgtgg tgggaaatac      360

actgtctcca aggatgaagc acaagaagcc accctcatct cctgtgacgc gtgctcgctg      420

attgtggagc tcctccatca gagctga                                          447


<210>  61
<211>  148
<212>  PRT
<213>  Mus musculus

<400>  61

Met Ala Leu Glu Gln Thr Leu Lys Lys Asp Trp Tyr Ser Ile Leu Gly 
1               5                   10                  15      


Ala Asp Pro Ser Ala Asn Met Ser Asp Leu Lys Gln Lys Tyr Gln Lys 
            20                  25                  30          


Leu Ile Leu Leu Tyr His Pro Asp Lys Gln Ser Ala Asp Val Pro Ala 
        35                  40                  45              


Gly Thr Met Glu Glu Cys Met Gln Lys Phe Ile Glu Ile Asp Gln Ala 
    50                  55                  60                  


Trp Lys Ile Leu Gly Asn Glu Glu Thr Lys Lys Lys Tyr Asp Leu Gln 
65                  70                  75                  80  


Arg His Glu Asp Glu Leu Arg Asn Val Gly Pro Val Asp Ala Gln Val 
                85                  90                  95      


Arg Leu Glu Glu Met Ser Trp Asn Gln Gly Asp Glu Ser Phe Phe Leu 
            100                 105                 110         


Ser Cys Arg Cys Gly Gly Lys Tyr Thr Val Ser Lys Asp Glu Ala Gln 
        115                 120                 125             


Glu Ala Thr Leu Ile Ser Cys Asp Ala Cys Ser Leu Ile Val Glu Leu 
    130                 135                 140                 


Leu His Gln Ser 
145             


<210>  62
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  62
atgctttatc tcatcgggtt gggcctggga gatgccaagg acatcacagt caagggcctg       60

gaagttgtta gacgctgcag tcgagtgtat ctggaagcct acacctcagt cctaactgta      120

gggaaggaag ccttggaaga gttttatgga agaaaattgg ttgttgctga tagagaagaa      180

gtggaacaag aagcagataa tattttaaag gatgctgata tcagtgatgt tgcattcctt      240

gtggttggtg atccatttgg ggccacaaca cacagtgatc ttgttctaag agcaacaaag      300

ctgggaattc cttatagagt tattcacaat gcctccataa tgaatgctgt aggctgctgt      360

ggtttacagt tatataagtt tggagagaca gtttctattg ttttttggac agacacttgg      420

agaccagaaa gcttctttga caaagtgaag aagaacagac aaaatggcat gcacacatta      480

tgtttactag acatcaaagt aaaggagcag tctttggaaa atctaatcaa gggaaggaag      540

atctatgaac ctccacggta tatgagtgta aaccaagcag cccagcagct tctggagatt      600

gttcaaaatc aaagaatacg aggagaagaa ccagcagtta ccgaggagac actttgtgtt      660

ggcttagcca gggttggagc cgacgaccag aaaattgcag caggcacttt aaggcaaatg      720

tgcactgtgg acttgggaga accattgcat tccttgatca tcacaggagg cagcatacat      780

ccaatggaga tggagatgct aagtctgttt tccataccag aaaatagctc agaatctcaa      840

agcatcaatg gactttga                                                    858


<210>  63
<211>  858
<212>  DNA
<213>  Homo sapiens

<400>  63
atgctttatc tcatcgggtt gggcctggga gatgccaagg acatcacagt caagggcctg       60

gaagttgtta gacgctgcag tcgagtgtat ctggaagcct acacctcagt cctaactgta      120

gggaaggaag ccttggaaga gttttatgga agaaaattgg ttgttgctga tagagaagaa      180

gtggaacaag aagcagataa tattttaaag gatgctgata tcagtgatgt tgcattcctt      240

gtggttggtg atccatttgg ggccacaaca cacagtgatc ttgttctaag agcaacaaag      300

ctgggaattc cttatagagt tattcacaat gcctccataa tgaatgctgt aggctgctgt      360

ggtttacagt tatataagtt tggagagaca gtttctattg ttttttggac agacacttgg      420

agaccagaaa gcttctttga caaagtgaag aagaacagac aaaatggcat gcacacatta      480

tgtttactag acatcaaagt aaaggagcag tctttggaaa atctaatcaa gggaaggaag      540

atctatgaac ctccacggta tatgagtgta aaccaagcag cccagcagct tctggagatt      600

gttcaaaatc aaagaatacg aggagaagaa ccagcagtta ccgaggagac actttgtgtt      660

ggcttagcca gggttggagc cgacgaccag aaaattgcag caggcacttt aaggcaaatg      720

tgcactgtgg acttgggaga accattgcat tccttgatca tcacaggagg cagcatacat      780

ccaatggaga tggagatgct aagtctgttt tccataccag aaaatagctc agaatctcaa      840

agcatcaatg gactttga                                                    858


<210>  64
<211>  855
<212>  DNA
<213>  Homo sapiens

<400>  64
atgctttatc tcatcgggtt gggcctggga gatgccaagg acatcacagt caagggcctg       60

gaagttgtta gacgctgcag tcgagtgtat ctggaagcct acacctcagt cctaactgta      120

gggaaggaag ccttggaaga gttttatgga agaaaattgg ttgttgctga tagagaagaa      180

gtggaacaag aagcagataa tattttaaag gatgctgata tcagtgatgt tgcattcctt      240

gtggttggtg atccatttgg ggccacaaca cacagtgatc ttgttctaag agcaacaaag      300

ctgggaattc cttatagagt tattcacaat gcctccataa tgaatgctgt aggctgctgt      360

ggtttacagt tatataagtt tggagagaca gtttctattg ttttttggac agacacttgg      420

agaccagaaa gcttctttga caaagtgaag aagaacagac aaaatggcat gcacacatta      480

tgtttactag acatcaaagt aaaggagcag tctttggaaa atctaatcaa gggaaggaag      540

atctatgaac ctccacggta tatgagtgta aaccaagcag cccagcagct tctggagatt      600

gttcaaaatc aaagaatacg aggagaagaa ccagttaccg aggagacact ttgtgttggc      660

ttagccaggg ttggagccga cgaccagaaa attgcagcag gcactttaag gcaaatgtgc      720

actgtggact tgggagaacc attgcattcc ttgatcatca caggaggcag catacatcca      780

atggagatgg agatgctaag tctgttttcc ataccagaaa atagctcaga atctcaaagc      840

atcaatggac tttga                                                       855


<210>  65
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Leu Tyr Leu Ile Gly Leu Gly Leu Gly Asp Ala Lys Asp Ile Thr 
1               5                   10                  15      


Val Lys Gly Leu Glu Val Val Arg Arg Cys Ser Arg Val Tyr Leu Glu 
            20                  25                  30          


Ala Tyr Thr Ser Val Leu Thr Val Gly Lys Glu Ala Leu Glu Glu Phe 
        35                  40                  45              


Tyr Gly Arg Lys Leu Val Val Ala Asp Arg Glu Glu Val Glu Gln Glu 
    50                  55                  60                  


Ala Asp Asn Ile Leu Lys Asp Ala Asp Ile Ser Asp Val Ala Phe Leu 
65                  70                  75                  80  


Val Val Gly Asp Pro Phe Gly Ala Thr Thr His Ser Asp Leu Val Leu 
                85                  90                  95      


Arg Ala Thr Lys Leu Gly Ile Pro Tyr Arg Val Ile His Asn Ala Ser 
            100                 105                 110         


Ile Met Asn Ala Val Gly Cys Cys Gly Leu Gln Leu Tyr Lys Phe Gly 
        115                 120                 125             


Glu Thr Val Ser Ile Val Phe Trp Thr Asp Thr Trp Arg Pro Glu Ser 
    130                 135                 140                 


Phe Phe Asp Lys Val Lys Lys Asn Arg Gln Asn Gly Met His Thr Leu 
145                 150                 155                 160 


Cys Leu Leu Asp Ile Lys Val Lys Glu Gln Ser Leu Glu Asn Leu Ile 
                165                 170                 175     


Lys Gly Arg Lys Ile Tyr Glu Pro Pro Arg Tyr Met Ser Val Asn Gln 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Ile Val Gln Asn Gln Arg Ile Arg Gly 
        195                 200                 205             


Glu Glu Pro Ala Val Thr Glu Glu Thr Leu Cys Val Gly Leu Ala Arg 
    210                 215                 220                 


Val Gly Ala Asp Asp Gln Lys Ile Ala Ala Gly Thr Leu Arg Gln Met 
225                 230                 235                 240 


Cys Thr Val Asp Leu Gly Glu Pro Leu His Ser Leu Ile Ile Thr Gly 
                245                 250                 255     


Gly Ser Ile His Pro Met Glu Met Glu Met Leu Ser Leu Phe Ser Ile 
            260                 265                 270         


Pro Glu Asn Ser Ser Glu Ser Gln Ser Ile Asn Gly Leu 
        275                 280                 285 


<210>  66
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Leu Tyr Leu Ile Gly Leu Gly Leu Gly Asp Ala Lys Asp Ile Thr 
1               5                   10                  15      


Val Lys Gly Leu Glu Val Val Arg Arg Cys Ser Arg Val Tyr Leu Glu 
            20                  25                  30          


Ala Tyr Thr Ser Val Leu Thr Val Gly Lys Glu Ala Leu Glu Glu Phe 
        35                  40                  45              


Tyr Gly Arg Lys Leu Val Val Ala Asp Arg Glu Glu Val Glu Gln Glu 
    50                  55                  60                  


Ala Asp Asn Ile Leu Lys Asp Ala Asp Ile Ser Asp Val Ala Phe Leu 
65                  70                  75                  80  


Val Val Gly Asp Pro Phe Gly Ala Thr Thr His Ser Asp Leu Val Leu 
                85                  90                  95      


Arg Ala Thr Lys Leu Gly Ile Pro Tyr Arg Val Ile His Asn Ala Ser 
            100                 105                 110         


Ile Met Asn Ala Val Gly Cys Cys Gly Leu Gln Leu Tyr Lys Phe Gly 
        115                 120                 125             


Glu Thr Val Ser Ile Val Phe Trp Thr Asp Thr Trp Arg Pro Glu Ser 
    130                 135                 140                 


Phe Phe Asp Lys Val Lys Lys Asn Arg Gln Asn Gly Met His Thr Leu 
145                 150                 155                 160 


Cys Leu Leu Asp Ile Lys Val Lys Glu Gln Ser Leu Glu Asn Leu Ile 
                165                 170                 175     


Lys Gly Arg Lys Ile Tyr Glu Pro Pro Arg Tyr Met Ser Val Asn Gln 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Ile Val Gln Asn Gln Arg Ile Arg Gly 
        195                 200                 205             


Glu Glu Pro Val Thr Glu Glu Thr Leu Cys Val Gly Leu Ala Arg Val 
    210                 215                 220                 


Gly Ala Asp Asp Gln Lys Ile Ala Ala Gly Thr Leu Arg Gln Met Cys 
225                 230                 235                 240 


Thr Val Asp Leu Gly Glu Pro Leu His Ser Leu Ile Ile Thr Gly Gly 
                245                 250                 255     


Ser Ile His Pro Met Glu Met Glu Met Leu Ser Leu Phe Ser Ile Pro 
            260                 265                 270         


Glu Asn Ser Ser Glu Ser Gln Ser Ile Asn Gly Leu 
        275                 280                 


<210>  67
<211>  846
<212>  DNA
<213>  Mus musculus

<400>  67
atgctttact tgatcggctt gggcctggga gatgccaagg acatcacagt caagggcctg       60

gaagttgtga gacgatgcag tcgcgtgtat ctggaagcct acacctcagt cctgactgta      120

gggaaggaag ccctggaaga gttttatgga agaaaattga ttcttgctga cagagaagaa      180

gtagaacaag aagcagataa tatttttaag gatgcagatg tcagtgatgt tgcgttcctt      240

gtggttggtg atccatttgg ggctacaaca cacagtgatc ttattctgag agcaacaaag      300

ttgggcatcc cttatcaagt tattcacaat gcctccataa tgaacgctgt aggctgctgt      360

ggtttgcagt tgtacaggtt tggagaaaca gtttctattg tgttttggac ggacacttgg      420

cgaccagaga gcttctttga caaggtgaag aggaaccggg ccaatggcat gcacacgctg      480

tgcttactcg atatcaaagt gaaggagcag tctctggaga acctcatcag aggaagaaag      540

atctatgaac cccctcggta catgagtgtg aaccaggcgg cccagcagct tctagagatt      600

gttcagaatc acagagcacg cggggaggaa ccagcaatca ctgaggagac actctgtgtc      660

ggcttagcca gagtgggagc tgaagatcag aaaattgcag caggcacgtt acagcagatg      720

tgcacagtga gcttgggaga accactgcat tctttggtca ttacaggggg caacctgcac      780

ccactggaga tggagatgct aagtctcttc tctataccgg aatcccagag tactgatgga      840

ctctga                                                                 846


<210>  68
<211>  281
<212>  PRT
<213>  Mus musculus

<400>  68

Met Leu Tyr Leu Ile Gly Leu Gly Leu Gly Asp Ala Lys Asp Ile Thr 
1               5                   10                  15      


Val Lys Gly Leu Glu Val Val Arg Arg Cys Ser Arg Val Tyr Leu Glu 
            20                  25                  30          


Ala Tyr Thr Ser Val Leu Thr Val Gly Lys Glu Ala Leu Glu Glu Phe 
        35                  40                  45              


Tyr Gly Arg Lys Leu Ile Leu Ala Asp Arg Glu Glu Val Glu Gln Glu 
    50                  55                  60                  


Ala Asp Asn Ile Phe Lys Asp Ala Asp Val Ser Asp Val Ala Phe Leu 
65                  70                  75                  80  


Val Val Gly Asp Pro Phe Gly Ala Thr Thr His Ser Asp Leu Ile Leu 
                85                  90                  95      


Arg Ala Thr Lys Leu Gly Ile Pro Tyr Gln Val Ile His Asn Ala Ser 
            100                 105                 110         


Ile Met Asn Ala Val Gly Cys Cys Gly Leu Gln Leu Tyr Arg Phe Gly 
        115                 120                 125             


Glu Thr Val Ser Ile Val Phe Trp Thr Asp Thr Trp Arg Pro Glu Ser 
    130                 135                 140                 


Phe Phe Asp Lys Val Lys Arg Asn Arg Ala Asn Gly Met His Thr Leu 
145                 150                 155                 160 


Cys Leu Leu Asp Ile Lys Val Lys Glu Gln Ser Leu Glu Asn Leu Ile 
                165                 170                 175     


Arg Gly Arg Lys Ile Tyr Glu Pro Pro Arg Tyr Met Ser Val Asn Gln 
            180                 185                 190         


Ala Ala Gln Gln Leu Leu Glu Ile Val Gln Asn His Arg Ala Arg Gly 
        195                 200                 205             


Glu Glu Pro Ala Ile Thr Glu Glu Thr Leu Cys Val Gly Leu Ala Arg 
    210                 215                 220                 


Val Gly Ala Glu Asp Gln Lys Ile Ala Ala Gly Thr Leu Gln Gln Met 
225                 230                 235                 240 


Cys Thr Val Ser Leu Gly Glu Pro Leu His Ser Leu Val Ile Thr Gly 
                245                 250                 255     


Gly Asn Leu His Pro Leu Glu Met Glu Met Leu Ser Leu Phe Ser Ile 
            260                 265                 270         


Pro Glu Ser Gln Ser Thr Asp Gly Leu 
        275                 280     


<210>  69
<211>  804
<212>  DNA
<213>  Homo sapiens

<400>  69
atgagggtcg cggctctgat cagtggtggg aaggacagct gctataatat gatgcagtgc       60

attgctgctg ggcatcagat cgttgcttta gcaaatctaa gaccagctga aaaccaagtg      120

gggtctgatg aactggatag ctacatgtat cagacagtgg ggcaccatgc cattgacttg      180

tatgcagaag caatggctct tcccctctat cgccgaacca taagaggaag gagcttggat      240

acaagacaag tgtacaccaa atgtgaaggt gatgaggttg aagatctcta tgagcttttg      300

aaacttgtta aggaaaaaga agaagtagag gggatatcag taggtgctat actttctgac      360

tatcagcgta ttcgagtgga aaatgtgtgt aaaaggctta atctccagcc tttagcttat      420

ctttggcaga gaaaccagga agatttgctc agagagatga tatcatctaa cattcaagca      480

atgatcatca aagtagcagc tttgggttta gatcctgata agcatcttgg gaaaaccctg      540

gatcaaatgg agccttatct catagagctt tctaagaagt atggagtaca tgtttgtgga      600

gaaggtggag agtatgaaac tttcactttg gattgccctc tatttaagaa gaaaataatt      660

gtggattcat cagaagtagt catacattca gctgatgcat ttgcacctgt ggcttatcta      720

cgctttttag aattgcactt ggaggacaag gtgtcctcag tgcctgacaa ctacagaaca      780

tctaattata tatataattt ttga                                             804


<210>  70
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  70
atgagggtcg cggctctgat cagtggtggg aaggacagct gctataatat gatgcagtgc       60

attgctgctg ggcatcagat cgttgcttta gcaaatctaa gaccagctga aaaccaagtg      120

gggtctgatg aactggatag ctacatgtat cagacagtgg ggcaccatgc cattgacttg      180

tatgcagaag caatggctct tcccctctat cgccgaacca taagaggaag gagcttggat      240

acaagacaag tgtacaccaa atgtgaaggt gatgaggttg aagatctcta tgagcttttg      300

aaacttgtta agggcatcac tagaatgacc ttgcttgctg aatatgatgc tctgaatctc      360

caagattttc acatgcattt gaaagtgggc agccaggcga ttgtttacag gactccaaat      420

gaactgtgca ctcacagcaa gtttgataaa cacacatttc ctccttttat cagtgagatt      480

gcaaaatgtg aagtatga                                                    498


<210>  71
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Arg Val Ala Ala Leu Ile Ser Gly Gly Lys Asp Ser Cys Tyr Asn 
1               5                   10                  15      


Met Met Gln Cys Ile Ala Ala Gly His Gln Ile Val Ala Leu Ala Asn 
            20                  25                  30          


Leu Arg Pro Ala Glu Asn Gln Val Gly Ser Asp Glu Leu Asp Ser Tyr 
        35                  40                  45              


Met Tyr Gln Thr Val Gly His His Ala Ile Asp Leu Tyr Ala Glu Ala 
    50                  55                  60                  


Met Ala Leu Pro Leu Tyr Arg Arg Thr Ile Arg Gly Arg Ser Leu Asp 
65                  70                  75                  80  


Thr Arg Gln Val Tyr Thr Lys Cys Glu Gly Asp Glu Val Glu Asp Leu 
                85                  90                  95      


Tyr Glu Leu Leu Lys Leu Val Lys Glu Lys Glu Glu Val Glu Gly Ile 
            100                 105                 110         


Ser Val Gly Ala Ile Leu Ser Asp Tyr Gln Arg Ile Arg Val Glu Asn 
        115                 120                 125             


Val Cys Lys Arg Leu Asn Leu Gln Pro Leu Ala Tyr Leu Trp Gln Arg 
    130                 135                 140                 


Asn Gln Glu Asp Leu Leu Arg Glu Met Ile Ser Ser Asn Ile Gln Ala 
145                 150                 155                 160 


Met Ile Ile Lys Val Ala Ala Leu Gly Leu Asp Pro Asp Lys His Leu 
                165                 170                 175     


Gly Lys Thr Leu Asp Gln Met Glu Pro Tyr Leu Ile Glu Leu Ser Lys 
            180                 185                 190         


Lys Tyr Gly Val His Val Cys Gly Glu Gly Gly Glu Tyr Glu Thr Phe 
        195                 200                 205             


Thr Leu Asp Cys Pro Leu Phe Lys Lys Lys Ile Ile Val Asp Ser Ser 
    210                 215                 220                 


Glu Val Val Ile His Ser Ala Asp Ala Phe Ala Pro Val Ala Tyr Leu 
225                 230                 235                 240 


Arg Phe Leu Glu Leu His Leu Glu Asp Lys Val Ser Ser Val Pro Asp 
                245                 250                 255     


Asn Tyr Arg Thr Ser Asn Tyr Ile Tyr Asn Phe 
            260                 265         


<210>  72
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Arg Val Ala Ala Leu Ile Ser Gly Gly Lys Asp Ser Cys Tyr Asn 
1               5                   10                  15      


Met Met Gln Cys Ile Ala Ala Gly His Gln Ile Val Ala Leu Ala Asn 
            20                  25                  30          


Leu Arg Pro Ala Glu Asn Gln Val Gly Ser Asp Glu Leu Asp Ser Tyr 
        35                  40                  45              


Met Tyr Gln Thr Val Gly His His Ala Ile Asp Leu Tyr Ala Glu Ala 
    50                  55                  60                  


Met Ala Leu Pro Leu Tyr Arg Arg Thr Ile Arg Gly Arg Ser Leu Asp 
65                  70                  75                  80  


Thr Arg Gln Val Tyr Thr Lys Cys Glu Gly Asp Glu Val Glu Asp Leu 
                85                  90                  95      


Tyr Glu Leu Leu Lys Leu Val Lys Gly Ile Thr Arg Met Thr Leu Leu 
            100                 105                 110         


Ala Glu Tyr Asp Ala Leu Asn Leu Gln Asp Phe His Met His Leu Lys 
        115                 120                 125             


Val Gly Ser Gln Ala Ile Val Tyr Arg Thr Pro Asn Glu Leu Cys Thr 
    130                 135                 140                 


His Ser Lys Phe Asp Lys His Thr Phe Pro Pro Phe Ile Ser Glu Ile 
145                 150                 155                 160 


Ala Lys Cys Glu Val 
                165 


<210>  73
<211>  816
<212>  DNA
<213>  Mus musculus

<400>  73
atgagggtcg cggccctgat cagtggtggg aaggacagct gttacaacat gatgcagtgc       60

attgctgagg ggcatcaaat tgttgcatta gcaaatctaa gaccagatga aaaccaagtg      120

gagtcagatg aactggatag ctatatgtat cagacagtgg gtcaccatgc cattgacttg      180

tatgctgaag caatggcgct gcccctgtat cgcagagcca tcagaggaag gagcttggag      240

acaggaagag tttatacgca atgtgaaggt gacgaggttg aagatctcta tgaactgttg      300

aaacttgtta aggaaaaaga agaaatcgaa ggggtatcag taggtgctat actctctgac      360

tatcaacgtg gacgagtaga aaatgtatgt aaacgactca atctccagcc tttagcttat      420

ctttggcaaa gaaaccagga agatttgctc cgagagatga tagcttctaa tatcaaggcc      480

attatcatca aagtagcagc tttgggctta gatcctgata agcatcttgg gaaaaccctg      540

gttgaaatgg agccttatct tttagagctt tctaagaagt acggtgtcca cgtgtgtgga      600

gaaggtggag agtatgagac attcacgttg gactgccctc tattcaagaa gaagattgtt      660

gtggactctt cagaagcagt catgcactca gcggatgcat tcgcacctgt ggcttatctg      720

cggctctccc ggctgcactt ggaagagaaa gtgagtaaag ctcagatggc agagattcca      780

aggcgagtga gaggtgtcgt cagtacctgc ggatga                                816


<210>  74
<211>  804
<212>  DNA
<213>  Mus musculus

<400>  74
atgagggtcg cggccctgat cagtggtggg aaggacagct gttacaacat gatgcagtgc       60

attgctgagg ggcatcaaat tgttgcatta gcaaatctaa gaccagatga aaaccaagtg      120

gagtcagatg aactggatag ctatatgtat cagacagtgg gtcaccatgc cattgacttg      180

tatgctgaag caatggcgct gcccctgtat cgcagagcca tcagaggaag gagcttggag      240

acaggaagag tttatacgca atgtgaaggt gacgaggttg aagatctcta tgaactgttg      300

aaacttgtta aggaaaaaga agaaatcgaa ggggtatcag taggtgctat actctctgac      360

tatcaacgtg gacgagtaga aaatgtatgt aaacgactca atctccagcc tttagcttat      420

ctttggcaaa gaaaccagga agatttgctc cgagagatga tagcttctaa tatcaaggcc      480

attatcatca aagtagcagc tttgggctta gatcctgata agcatcttgg gaaaaccctg      540

gttgaaatgg agccttatct tttagagctt tctaagaagt acggtgtcca cgtgtgtgga      600

gaaggtggag agtatgagac attcacgttg gactgccctc tattcaagaa gaagattgtt      660

gtggactctt cagaagcagt catgcactca gcggatgcat tcgcacctgt ggcttatctg      720

cggctctccc ggctgcactt ggaagagaaa gtgtcgtcag tacctgcgga tgatgaaaca      780

gctaactcta tacacagctc ttaa                                             804


<210>  75
<211>  678
<212>  DNA
<213>  Mus musculus

<400>  75
atgagggtcg cggccctgat cagtggtggg aaggacagct gttacaacat gatgcagtgc       60

attgctgagg ggcatcaaat tgttgcatta gcaaatctaa gaccagatga aaaccaagtg      120

gagtcagatg aactggatag ctatatgtat cagacagtgg gtcaccatgc cattgacttg      180

tatgctgaag caatggcgct gcccctgtat cgcagagcca tcagaggaag gagcttggag      240

acaggaagag tttatacgca atgtgaaggt gacgaggttg aagatctcta tgaactgttg      300

aaacttgtta aggaaaaaga agaaatcgaa ggggtatcag taggtgctat actctctgac      360

tatcaacgtg gacgagtaga aaatgtatgt aaacgactca atctccagcc tttagcttat      420

ctttggcaaa gaaaccagga agatttgctc cgagagatga tagcttctaa tatcaaggcc      480

attatcatca aagtagcagc tttgggctta gatcctgata agcatcttgg gaaaaccctg      540

gttgaaatgg agccttatct tttagaggga ctcttcagaa gcagtcatgc actcagcgga      600

tgcattcgca cctgtggctt atctgcggct ctcccggctg cacttggaag agaaagtgtc      660

gtcagtacct gcggatga                                                    678


<210>  76
<211>  271
<212>  PRT
<213>  Mus musculus

<400>  76

Met Arg Val Ala Ala Leu Ile Ser Gly Gly Lys Asp Ser Cys Tyr Asn 
1               5                   10                  15      


Met Met Gln Cys Ile Ala Glu Gly His Gln Ile Val Ala Leu Ala Asn 
            20                  25                  30          


Leu Arg Pro Asp Glu Asn Gln Val Glu Ser Asp Glu Leu Asp Ser Tyr 
        35                  40                  45              


Met Tyr Gln Thr Val Gly His His Ala Ile Asp Leu Tyr Ala Glu Ala 
    50                  55                  60                  


Met Ala Leu Pro Leu Tyr Arg Arg Ala Ile Arg Gly Arg Ser Leu Glu 
65                  70                  75                  80  


Thr Gly Arg Val Tyr Thr Gln Cys Glu Gly Asp Glu Val Glu Asp Leu 
                85                  90                  95      


Tyr Glu Leu Leu Lys Leu Val Lys Glu Lys Glu Glu Ile Glu Gly Val 
            100                 105                 110         


Ser Val Gly Ala Ile Leu Ser Asp Tyr Gln Arg Gly Arg Val Glu Asn 
        115                 120                 125             


Val Cys Lys Arg Leu Asn Leu Gln Pro Leu Ala Tyr Leu Trp Gln Arg 
    130                 135                 140                 


Asn Gln Glu Asp Leu Leu Arg Glu Met Ile Ala Ser Asn Ile Lys Ala 
145                 150                 155                 160 


Ile Ile Ile Lys Val Ala Ala Leu Gly Leu Asp Pro Asp Lys His Leu 
                165                 170                 175     


Gly Lys Thr Leu Val Glu Met Glu Pro Tyr Leu Leu Glu Leu Ser Lys 
            180                 185                 190         


Lys Tyr Gly Val His Val Cys Gly Glu Gly Gly Glu Tyr Glu Thr Phe 
        195                 200                 205             


Thr Leu Asp Cys Pro Leu Phe Lys Lys Lys Ile Val Val Asp Ser Ser 
    210                 215                 220                 


Glu Ala Val Met His Ser Ala Asp Ala Phe Ala Pro Val Ala Tyr Leu 
225                 230                 235                 240 


Arg Leu Ser Arg Leu His Leu Glu Glu Lys Val Ser Lys Ala Gln Met 
                245                 250                 255     


Ala Glu Ile Pro Arg Arg Val Arg Gly Val Val Ser Thr Cys Gly 
            260                 265                 270     


<210>  77
<211>  267
<212>  PRT
<213>  Mus musculus

<400>  77

Met Arg Val Ala Ala Leu Ile Ser Gly Gly Lys Asp Ser Cys Tyr Asn 
1               5                   10                  15      


Met Met Gln Cys Ile Ala Glu Gly His Gln Ile Val Ala Leu Ala Asn 
            20                  25                  30          


Leu Arg Pro Asp Glu Asn Gln Val Glu Ser Asp Glu Leu Asp Ser Tyr 
        35                  40                  45              


Met Tyr Gln Thr Val Gly His His Ala Ile Asp Leu Tyr Ala Glu Ala 
    50                  55                  60                  


Met Ala Leu Pro Leu Tyr Arg Arg Ala Ile Arg Gly Arg Ser Leu Glu 
65                  70                  75                  80  


Thr Gly Arg Val Tyr Thr Gln Cys Glu Gly Asp Glu Val Glu Asp Leu 
                85                  90                  95      


Tyr Glu Leu Leu Lys Leu Val Lys Glu Lys Glu Glu Ile Glu Gly Val 
            100                 105                 110         


Ser Val Gly Ala Ile Leu Ser Asp Tyr Gln Arg Gly Arg Val Glu Asn 
        115                 120                 125             


Val Cys Lys Arg Leu Asn Leu Gln Pro Leu Ala Tyr Leu Trp Gln Arg 
    130                 135                 140                 


Asn Gln Glu Asp Leu Leu Arg Glu Met Ile Ala Ser Asn Ile Lys Ala 
145                 150                 155                 160 


Ile Ile Ile Lys Val Ala Ala Leu Gly Leu Asp Pro Asp Lys His Leu 
                165                 170                 175     


Gly Lys Thr Leu Val Glu Met Glu Pro Tyr Leu Leu Glu Leu Ser Lys 
            180                 185                 190         


Lys Tyr Gly Val His Val Cys Gly Glu Gly Gly Glu Tyr Glu Thr Phe 
        195                 200                 205             


Thr Leu Asp Cys Pro Leu Phe Lys Lys Lys Ile Val Val Asp Ser Ser 
    210                 215                 220                 


Glu Ala Val Met His Ser Ala Asp Ala Phe Ala Pro Val Ala Tyr Leu 
225                 230                 235                 240 


Arg Leu Ser Arg Leu His Leu Glu Glu Lys Val Ser Ser Val Pro Ala 
                245                 250                 255     


Asp Asp Glu Thr Ala Asn Ser Ile His Ser Ser 
            260                 265         


<210>  78
<211>  225
<212>  PRT
<213>  Mus musculus

<400>  78

Met Arg Val Ala Ala Leu Ile Ser Gly Gly Lys Asp Ser Cys Tyr Asn 
1               5                   10                  15      


Met Met Gln Cys Ile Ala Glu Gly His Gln Ile Val Ala Leu Ala Asn 
            20                  25                  30          


Leu Arg Pro Asp Glu Asn Gln Val Glu Ser Asp Glu Leu Asp Ser Tyr 
        35                  40                  45              


Met Tyr Gln Thr Val Gly His His Ala Ile Asp Leu Tyr Ala Glu Ala 
    50                  55                  60                  


Met Ala Leu Pro Leu Tyr Arg Arg Ala Ile Arg Gly Arg Ser Leu Glu 
65                  70                  75                  80  


Thr Gly Arg Val Tyr Thr Gln Cys Glu Gly Asp Glu Val Glu Asp Leu 
                85                  90                  95      


Tyr Glu Leu Leu Lys Leu Val Lys Glu Lys Glu Glu Ile Glu Gly Val 
            100                 105                 110         


Ser Val Gly Ala Ile Leu Ser Asp Tyr Gln Arg Gly Arg Val Glu Asn 
        115                 120                 125             


Val Cys Lys Arg Leu Asn Leu Gln Pro Leu Ala Tyr Leu Trp Gln Arg 
    130                 135                 140                 


Asn Gln Glu Asp Leu Leu Arg Glu Met Ile Ala Ser Asn Ile Lys Ala 
145                 150                 155                 160 


Ile Ile Ile Lys Val Ala Ala Leu Gly Leu Asp Pro Asp Lys His Leu 
                165                 170                 175     


Gly Lys Thr Leu Val Glu Met Glu Pro Tyr Leu Leu Glu Gly Leu Phe 
            180                 185                 190         


Arg Ser Ser His Ala Leu Ser Gly Cys Ile Arg Thr Cys Gly Leu Ser 
        195                 200                 205             


Ala Ala Leu Pro Ala Ala Leu Gly Arg Glu Ser Val Val Ser Thr Cys 
    210                 215                 220                 


Gly 
225 


<210>  79
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  79
atgatgggct gtttcgccct gcaaacggtg gacaccgagc tgaccgcgga ctcggtggag       60

tggtgcccgc tgcaaggctg caggcacctg ctggcgtgcg ggacctacca gctgcggcgg      120

ccggaggacc ggcctgccgg cccccagaac aagggtggaa tggaagttaa ggagcctcag      180

gtccgtttag gccgtctctt cctgtacagt ttcaatgaca acaactctat tcaccctctg      240

gtcgaggtcc aaagaaaaga tacttctgca atcctggaca tgaaatggtg tcacatcccg      300

gtggctggac atgccctctt gggcttggca gatgccagtg gatccataca actgctccgc      360

ctggtggaat ctgagaagag ccacgtgctg gagccattgt ccagccttgc cctggaggag      420

cagtgtctgg ctttgtccct agattggtcc actgggaaaa ctggaagggc cggggaccag      480

cccttgaaga tcatcagcag tgactccaca gggcagctcc acctcctgat ggtgaatgag      540

acgaggccca ggctgcagaa agtggcctca tggcaggcac atcaattcga ggcctggatt      600

gctgctttca attactggca tccagaaatt gtgtattcag ggggcgacga tggccttctg      660

aggggctggg acaccagggt acccggcaaa tttctcttca ccagcaaaag acacaccatg      720

ggtgtgtgca gcatccagag cagccctcat cgggagcaca tcctggccac gggaagctat      780

gatgaacaca tcctactgtg ggacacacga aacatgaagc agccgttggc agatacgcct      840

gtgcagggtg gggtatggag aatcaagtgg caccctttcc accaccacct gctcctggcc      900

gcctgcatgc acagtggctt taagatcctc aactgccaaa aggcaatgga ggagaggcag      960

gaggcgacgg tcctgacatc tcacacattg cccgactcgc tggtgtatgg agccgactgg     1020

tcctggctgc tcttccgttc tctgcagcgg gccccctcgt ggtcctttcc tagcaaccta     1080

ggaaccaaga cggcagacct gaagggtgca agcgagttgc caacaccctg tcatgaatgc     1140

agagaggata acgatgggga gggccatgcc agaccccaga gtggaatgaa gccactcaca     1200

gagggcatga ggaagaatgg cacctggctg caggctacag cagccaccac acgtgactgt     1260

ggcgtgaacc cagaagaagc agactcagcc ttcagcctcc tggccacctg ctccttctat     1320

gaccatgcgc tccacctctg ggagtgggag gggaactga                            1359


<210>  80
<211>  1293
<212>  DNA
<213>  Homo sapiens

<400>  80
atgatgggct gtttcgccct gcaaacggtg gacaccgagc tgaccgcgga ctcggtggag       60

tggtgcccgc tgcaaggctg caggcacctg ctggcgtgcg ggacctacca gctgcggcgg      120

ccggaggacc ggcctgccgg cccccagaac aagggtggaa tggaagttaa ggagcctcag      180

gtccgtttag gccgtctctt cctgtacagt ttcaatgaca acaactctat tcaccctctg      240

gtcgaggtcc aaagaaaaga tacttctgca atcctggaca tgaaatggtg tcacatcccg      300

gtggctggac atgccctctt gggcttggca gatgccagtg gatccataca actgctccgc      360

ctggtggaat ctgagaagag ccacgtgctg gagccattgt ccagccttgc cctggaggag      420

cagtgtctgg ctttgtccct agattggtcc actgggaaaa ctggaagggc cggggaccag      480

cccttgaaga tcatcagcag tgactccaca gggcagctcc acctcctgat ggtgaatgag      540

acgaggccca ggctgcagaa agtggcctca tggcaggcac atcaattcga ggcctggatt      600

gctgctttca attactggca tccagaaatt gtgtattcag ggggcgacga tggccttctg      660

aggggctggg acaccagggt acccggcaaa tttctcttca ccagcaaaag ctatgatgaa      720

cacatcctac tgtgggacac acgaaacatg aagcagccgt tggcagatac gcctgtgcag      780

ggtggggtat ggagaatcaa gtggcaccct ttccaccacc acctgctcct ggccgcctgc      840

atgcacagtg gctttaagat cctcaactgc caaaaggcaa tggaggagag gcaggaggcg      900

acggtcctga catctcacac attgcccgac tcgctggtgt atggagccga ctggtcctgg      960

ctgctcttcc gttctctgca gcgggccccc tcgtggtcct ttcctagcaa cctaggaacc     1020

aagacggcag acctgaaggg tgcaagcgag ttgccaacac cctgtcatga atgcagagag     1080

gataacgatg gggagggcca tgccagaccc cagagtggaa tgaagccact cacagagggc     1140

atgaggaaga atggcacctg gctgcaggct acagcagcca ccacacgtga ctgtggcgtg     1200

aacccagaag aagcagactc agccttcagc ctcctggcca cctgctcctt ctatgaccat     1260

gcgctccacc tctgggagtg ggaggggaac tga                                  1293


<210>  81
<211>  1011
<212>  DNA
<213>  Homo sapiens

<400>  81
atgatgggct gtttcgccct gcaaacggtg gacaccgagc tgaccgcgga ctcggtggag       60

tggtgcccgc tgcaaggctg caggcacctg ctggcgtgcg ggacctacca gctgcggcgg      120

ccggaggacc ggcctgccgg cccccagaac aagggtggaa tggaagttaa ggagcctcag      180

gtccgtttag gccgtctctt cctgtacagt ttcaatgaca acaactctat tcaccctctg      240

gtcgaggtcc aaagaaaaga tacttctgca atcctggaca tgaaatggtg tcacatcccg      300

gtggctggac atgccctctt gggcttggca gatgccagtg gatccataca actgctccgc      360

ctggtggaat ctgagaagag ccacgtgctg gagccattgt ccagccttgc cctggaggag      420

cagtgtctgg ctttgtccct agattggtcc actgggaaaa ctggaagggc cggggaccag      480

cccttgaaga tcatcagcag tgactccaca gggcagctcc acctcctgat ggtgaatgag      540

acgaggccca ggctgcagaa agtggcctca tggcaggcac atcaattcga ggcctggatt      600

gctgctttca attactggca tccagaaatt gtgtattcag ggggcgacga tggccttctg      660

aggggctggg acaccagggt acccggcaaa tttctcttca ccagcaaaag acacaccatg      720

ggtgtgtgca gcatccagag cagccctcat cgggagcaca tcctggccac gggaagctat      780

gatgaacaca tcctactgtg ggacacacga aacatgaagc agccgttggc agatacgcct      840

gtgcagggtg gggtatggag aatcaagtgg caccctttcc accaccacct gctcctggcc      900

gcctgcatgc acagtggctt taagatcctc aactgccaaa aggcaatggc tgtagaagag      960

gtcctgctgg cccgagtgga cgtgttgagc gattgctgga tgaaagacta g              1011


<210>  82
<211>  972
<212>  DNA
<213>  Homo sapiens

<400>  82
atgatgggct gtttcgccct gcaaacggtg gacaccgagc tgaccgcgga ctcggtggag       60

tggtgcccgc tgcaaggctg caggcacctg ctggcgtgcg ggacctacca gctgcggcgg      120

ccggaggacc ggcctgccgg cccccagaac aagggtggaa tggaagttaa ggagcctcag      180

gtccgtttag gccgtctctt cctgtacagt ttcaatgaca acaactctat tcaccctctg      240

gtcgaggtcc aaagaaaaga tacttctgca atcctggaca tgaaatggtg tcacatcccg      300

gtggctggac atgccctctt gggcttggca gatgccagtg gatccataca actgctccgc      360

ctggtggaat ctgagaagag ccacgtgctg gagccattgt ccagccttgc cctggaggag      420

cagtgtctgg ctttgtccct agattggtcc actgggaaaa ctggaagggc cggggaccag      480

cccttgaaga tcatcagcag tgactccaca gggcagctcc acctcctgat ggtgaatgag      540

acgaggccca ggctgcagaa agtggcctca tggcaggcac atcaattcga ggcctggatt      600

gctgctttca attactggca tccagaaatt gtgtattcag ggggcgacga tggccttctg      660

aggggctggg acaccagggt acccggcaaa tttctcttca ccagcaaaag acacaccatg      720

ggtgtgtgca gcatccagag cagccctcat cgggagcaca tcctggccac gggaagctat      780

gatgaacaca tcctactgtg ggacacacga aacatgaagc agccgttggc agatacgcct      840

gtgcagggtg gggtatggag aatcaagtgg caccctttcc accaccacct gctcctggcc      900

gcctgcatgc acagtggctt taagatcctc aactgccaaa aggcaatggg ctgtggctct      960

ctgagggctt ag                                                          972


<210>  83
<211>  957
<212>  DNA
<213>  Homo sapiens

<400>  83
atgccctctt gggcttggca gatgccagtg gatccataca actgctccgc ctggtggaat       60

ctgagggccg gggaccagcc cttgaagatc atcagcagtg actccacagg gcagctccac      120

ctcctgatgg tgaatgagac gaggcccagg ctgcagaaag tggcctcatg gcaggcacat      180

caattcgagg cctggattgc tgctttcaat tactggcatc cagaaattgt gtattcaggg      240

ggcgacgatg gccttctgag gggctgggac accagggtac ccggcaaatt tctcttcacc      300

agcaaaagac acaccatggg tgtgtgcagc atccagagca gccctcatcg ggagcacatc      360

ctggccacgg gaagctatga tgaacacatc ctactgtggg acacacgaaa catgaagcag      420

ccgttggcag atacgcctgt gcagggtggg gtatggagaa tcaagtggca ccctttccac      480

caccacctgc tcctggccgc ctgcatgcac agtggcttta agatcctcaa ctgccaaaag      540

gcaatggagg agaggcagga ggcgacggtc ctgacatctc acacattgcc cgactcgctg      600

gtgtatggag ccgactggtc ctggctgctc ttccgttctc tgcagcgggc cccctcgtgg      660

tcctttccta gcaacctagg aaccaagacg gcagacctga agggtgcaag cgagttgcca      720

acaccctgtc atgaatgcag agaggataac gatggggagg gccatgccag accccagagt      780

ggaatgaagc cactcacaga gggcatgagg aagaatggca cctggctgca ggctacagca      840

gccaccacac gtgactgtgg cgtgaaccca gaagaagcag actcagcctt cagcctcctg      900

gccacctgct ccttctatga ccatgcgctc cacctctggg agtgggaggg gaactga         957


<210>  84
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  84
atgatgggct gtttcgccct gcaaacggtg gacaccgagc tgaccgcgga ctcggtggag       60

tggtgcccgc tgcaaggctg caggcacctg ctggcgtgcg ggacctacca gctgcggcgg      120

ccggaggacc ggcctgccgg cccccagaac aagggtggaa tggaagttaa ggagcctcag      180

gtccgtttag gccgtctctt cctgtacagt ttcaatgaca acaactctat tcaccctctg      240

gtcgaggtcc aaagaaaaga tacttctgca atcctggaca tgaaatggtg tcacatcccg      300

gtggctggac atgccctctt gggcttggca gatgccagtg gatccataca actgctccgc      360

ctggtggaat ctgagaagag ccacgtgctg gagccattgt ccagccttgc cctggaggag      420

cagtgtctgg ctttgtccct agattggtcc actgggaaaa ctggaagggc cggggaccag      480

cccttgaaga tcatcagcag tgactccaca gggcagctcc acctcctgat ggtgaatgag      540

acgaggccca ggctgcagaa agtggcctca tggcaggcac atcaattcga ggcctggatt      600

gctgctttca attactggca tccagaaatt gtgtattcag ggggcgacga tggccttctg      660

aggggctggg acaccagggt acccggcaaa tttctcttca ccagcaaaag ctatgatgaa      720

cacatcctac tgtgggacac acgaaacatg aagcagccgt tggcagatac gcctgtgcag      780

ggtggggtat ggagaatcaa gtggcaccct ttccaccacc acctgctcct ggccgcctgc      840

atgcacagtg gctttaagat cctcaactgc caaaaggcaa tgggctgtgg ctctctgagg      900

gcttag                                                                 906


<210>  85
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  85
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  86
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  86
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  87
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  87
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  88
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  88
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  89
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  89
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  90
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  90
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  91
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  91
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  92
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  92
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  93
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  93
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  94
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  94
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  95
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  95
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  96
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  96
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  97
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  97
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  98
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  98
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  99
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  99
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  100
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  100
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  101
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  101
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  102
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  102
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agacacacca tgggtgtgtg cagcatccag agcagccctc atcgggagca catcctggcc      240

acgggaagct atgatgaaca catcctactg tgggacacac gaaacatgaa gcagccgttg      300

gcagatacgc ctgtgcaggg tggggtatgg agaatcaagt ggcacccttt ccaccaccac      360

ctgctcctgg ccgcctgcat gcacagtggc tttaagatcc tcaactgcca aaaggcaatg      420

gaggagaggc aggaggcgac ggtcctgaca tctcacacat tgcccgactc gctggtgtat      480

ggagccgact ggtcctggct gctcttccgt tctctgcagc gggccccctc gtggtccttt      540

cctagcaacc taggaaccaa gacggcagac ctgaagggtg caagcgagtt gccaacaccc      600

tgtcatgaat gcagagagga taacgatggg gagggccatg ccagacccca gagtggaatg      660

aagccactca cagagggcat gaggaagaat ggcacctggc tgcaggctac agcagccacc      720

acacgtgact gtggcgtgaa cccagaagaa gcagactcag ccttcagcct cctggccacc      780

tgctccttct atgaccatgc gctccacctc tgggagtggg aggggaactg a               831


<210>  103
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  103
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agctatgatg aacacatcct actgtgggac acacgaaaca tgaagcagcc gttggcagat      240

acgcctgtgc agggtggggt atggagaatc aagtggcacc ctttccacca ccacctgctc      300

ctggccgcct gcatgcacag tggctttaag atcctcaact gccaaaaggc aatggaggag      360

aggcaggagg cgacggtcct gacatctcac acattgcccg actcgctggt gtatggagcc      420

gactggtcct ggctgctctt ccgttctctg cagcgggccc cctcgtggtc ctttcctagc      480

aacctaggaa ccaagacggc agacctgaag ggtgcaagcg agttgccaac accctgtcat      540

gaatgcagag aggataacga tggggagggc catgccagac cccagagtgg aatgaagcca      600

ctcacagagg gcatgaggaa gaatggcacc tggctgcagg ctacagcagc caccacacgt      660

gactgtggcg tgaacccaga agaagcagac tcagccttca gcctcctggc cacctgctcc      720

ttctatgacc atgcgctcca cctctgggag tgggagggga actga                      765


<210>  104
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  104
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agctatgatg aacacatcct actgtgggac acacgaaaca tgaagcagcc gttggcagat      240

acgcctgtgc agggtggggt atggagaatc aagtggcacc ctttccacca ccacctgctc      300

ctggccgcct gcatgcacag tggctttaag atcctcaact gccaaaaggc aatggaggag      360

aggcaggagg cgacggtcct gacatctcac acattgcccg actcgctggt gtatggagcc      420

gactggtcct ggctgctctt ccgttctctg cagcgggccc cctcgtggtc ctttcctagc      480

aacctaggaa ccaagacggc agacctgaag ggtgcaagcg agttgccaac accctgtcat      540

gaatgcagag aggataacga tggggagggc catgccagac cccagagtgg aatgaagcca      600

ctcacagagg gcatgaggaa gaatggcacc tggctgcagg ctacagcagc caccacacgt      660

gactgtggcg tgaacccaga agaagcagac tcagccttca gcctcctggc cacctgctcc      720

ttctatgacc atgcgctcca cctctgggag tgggagggga actga                      765


<210>  105
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  105
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agctatgatg aacacatcct actgtgggac acacgaaaca tgaagcagcc gttggcagat      240

acgcctgtgc agggtggggt atggagaatc aagtggcacc ctttccacca ccacctgctc      300

ctggccgcct gcatgcacag tggctttaag atcctcaact gccaaaaggc aatggaggag      360

aggcaggagg cgacggtcct gacatctcac acattgcccg actcgctggt gtatggagcc      420

gactggtcct ggctgctctt ccgttctctg cagcgggccc cctcgtggtc ctttcctagc      480

aacctaggaa ccaagacggc agacctgaag ggtgcaagcg agttgccaac accctgtcat      540

gaatgcagag aggataacga tggggagggc catgccagac cccagagtgg aatgaagcca      600

ctcacagagg gcatgaggaa gaatggcacc tggctgcagg ctacagcagc caccacacgt      660

gactgtggcg tgaacccaga agaagcagac tcagccttca gcctcctggc cacctgctcc      720

ttctatgacc atgcgctcca cctctgggag tgggagggga actga                      765


<210>  106
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  106
atggtgaatg agacgaggcc caggctgcag aaagtggcct catggcaggc acatcaattc       60

gaggcctgga ttgctgcttt caattactgg catccagaaa ttgtgtattc agggggcgac      120

gatggccttc tgaggggctg ggacaccagg gtacccggca aatttctctt caccagcaaa      180

agctatgatg aacacatcct actgtgggac acacgaaaca tgaagcagcc gttggcagat      240

acgcctgtgc agggtggggt atggagaatc aagtggcacc ctttccacca ccacctgctc      300

ctggccgcct gcatgcacag tggctttaag atcctcaact gccaaaaggc aatggaggag      360

aggcaggagg cgacggtcct gacatctcac acattgcccg actcgctggt gtatggagcc      420

gactggtcct ggctgctctt ccgttctctg cagcgggccc cctcgtggtc ctttcctagc      480

aacctaggaa ccaagacggc agacctgaag ggtgcaagcg agttgccaac accctgtcat      540

gaatgcagag aggataacga tggggagggc catgccagac cccagagtgg aatgaagcca      600

ctcacagagg gcatgaggaa gaatggcacc tggctgcagg ctacagcagc caccacacgt      660

gactgtggcg tgaacccaga agaagcagac tcagccttca gcctcctggc cacctgctcc      720

ttctatgacc atgcgctcca cctctgggag tgggagggga actga                      765


<210>  107
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Met Gly Cys Phe Ala Leu Gln Thr Val Asp Thr Glu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Val Glu Trp Cys Pro Leu Gln Gly Cys Arg His Leu Leu Ala 
            20                  25                  30          


Cys Gly Thr Tyr Gln Leu Arg Arg Pro Glu Asp Arg Pro Ala Gly Pro 
        35                  40                  45              


Gln Asn Lys Gly Gly Met Glu Val Lys Glu Pro Gln Val Arg Leu Gly 
    50                  55                  60                  


Arg Leu Phe Leu Tyr Ser Phe Asn Asp Asn Asn Ser Ile His Pro Leu 
65                  70                  75                  80  


Val Glu Val Gln Arg Lys Asp Thr Ser Ala Ile Leu Asp Met Lys Trp 
                85                  90                  95      


Cys His Ile Pro Val Ala Gly His Ala Leu Leu Gly Leu Ala Asp Ala 
            100                 105                 110         


Ser Gly Ser Ile Gln Leu Leu Arg Leu Val Glu Ser Glu Lys Ser His 
        115                 120                 125             


Val Leu Glu Pro Leu Ser Ser Leu Ala Leu Glu Glu Gln Cys Leu Ala 
    130                 135                 140                 


Leu Ser Leu Asp Trp Ser Thr Gly Lys Thr Gly Arg Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Leu Lys Ile Ile Ser Ser Asp Ser Thr Gly Gln Leu His Leu Leu 
                165                 170                 175     


Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
            180                 185                 190         


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
        195                 200                 205             


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
    210                 215                 220                 


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Arg His Thr Met 
225                 230                 235                 240 


Gly Val Cys Ser Ile Gln Ser Ser Pro His Arg Glu His Ile Leu Ala 
                245                 250                 255     


Thr Gly Ser Tyr Asp Glu His Ile Leu Leu Trp Asp Thr Arg Asn Met 
            260                 265                 270         


Lys Gln Pro Leu Ala Asp Thr Pro Val Gln Gly Gly Val Trp Arg Ile 
        275                 280                 285             


Lys Trp His Pro Phe His His His Leu Leu Leu Ala Ala Cys Met His 
    290                 295                 300                 


Ser Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Met Glu Glu Arg Gln 
305                 310                 315                 320 


Glu Ala Thr Val Leu Thr Ser His Thr Leu Pro Asp Ser Leu Val Tyr 
                325                 330                 335     


Gly Ala Asp Trp Ser Trp Leu Leu Phe Arg Ser Leu Gln Arg Ala Pro 
            340                 345                 350         


Ser Trp Ser Phe Pro Ser Asn Leu Gly Thr Lys Thr Ala Asp Leu Lys 
        355                 360                 365             


Gly Ala Ser Glu Leu Pro Thr Pro Cys His Glu Cys Arg Glu Asp Asn 
    370                 375                 380                 


Asp Gly Glu Gly His Ala Arg Pro Gln Ser Gly Met Lys Pro Leu Thr 
385                 390                 395                 400 


Glu Gly Met Arg Lys Asn Gly Thr Trp Leu Gln Ala Thr Ala Ala Thr 
                405                 410                 415     


Thr Arg Asp Cys Gly Val Asn Pro Glu Glu Ala Asp Ser Ala Phe Ser 
            420                 425                 430         


Leu Leu Ala Thr Cys Ser Phe Tyr Asp His Ala Leu His Leu Trp Glu 
        435                 440                 445             


Trp Glu Gly Asn 
    450         


<210>  108
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Met Gly Cys Phe Ala Leu Gln Thr Val Asp Thr Glu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Val Glu Trp Cys Pro Leu Gln Gly Cys Arg His Leu Leu Ala 
            20                  25                  30          


Cys Gly Thr Tyr Gln Leu Arg Arg Pro Glu Asp Arg Pro Ala Gly Pro 
        35                  40                  45              


Gln Asn Lys Gly Gly Met Glu Val Lys Glu Pro Gln Val Arg Leu Gly 
    50                  55                  60                  


Arg Leu Phe Leu Tyr Ser Phe Asn Asp Asn Asn Ser Ile His Pro Leu 
65                  70                  75                  80  


Val Glu Val Gln Arg Lys Asp Thr Ser Ala Ile Leu Asp Met Lys Trp 
                85                  90                  95      


Cys His Ile Pro Val Ala Gly His Ala Leu Leu Gly Leu Ala Asp Ala 
            100                 105                 110         


Ser Gly Ser Ile Gln Leu Leu Arg Leu Val Glu Ser Glu Lys Ser His 
        115                 120                 125             


Val Leu Glu Pro Leu Ser Ser Leu Ala Leu Glu Glu Gln Cys Leu Ala 
    130                 135                 140                 


Leu Ser Leu Asp Trp Ser Thr Gly Lys Thr Gly Arg Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Leu Lys Ile Ile Ser Ser Asp Ser Thr Gly Gln Leu His Leu Leu 
                165                 170                 175     


Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
            180                 185                 190         


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
        195                 200                 205             


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
    210                 215                 220                 


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Ser Tyr Asp Glu 
225                 230                 235                 240 


His Ile Leu Leu Trp Asp Thr Arg Asn Met Lys Gln Pro Leu Ala Asp 
                245                 250                 255     


Thr Pro Val Gln Gly Gly Val Trp Arg Ile Lys Trp His Pro Phe His 
            260                 265                 270         


His His Leu Leu Leu Ala Ala Cys Met His Ser Gly Phe Lys Ile Leu 
        275                 280                 285             


Asn Cys Gln Lys Ala Met Glu Glu Arg Gln Glu Ala Thr Val Leu Thr 
    290                 295                 300                 


Ser His Thr Leu Pro Asp Ser Leu Val Tyr Gly Ala Asp Trp Ser Trp 
305                 310                 315                 320 


Leu Leu Phe Arg Ser Leu Gln Arg Ala Pro Ser Trp Ser Phe Pro Ser 
                325                 330                 335     


Asn Leu Gly Thr Lys Thr Ala Asp Leu Lys Gly Ala Ser Glu Leu Pro 
            340                 345                 350         


Thr Pro Cys His Glu Cys Arg Glu Asp Asn Asp Gly Glu Gly His Ala 
        355                 360                 365             


Arg Pro Gln Ser Gly Met Lys Pro Leu Thr Glu Gly Met Arg Lys Asn 
    370                 375                 380                 


Gly Thr Trp Leu Gln Ala Thr Ala Ala Thr Thr Arg Asp Cys Gly Val 
385                 390                 395                 400 


Asn Pro Glu Glu Ala Asp Ser Ala Phe Ser Leu Leu Ala Thr Cys Ser 
                405                 410                 415     


Phe Tyr Asp His Ala Leu His Leu Trp Glu Trp Glu Gly Asn 
            420                 425                 430 


<210>  109
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Met Gly Cys Phe Ala Leu Gln Thr Val Asp Thr Glu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Val Glu Trp Cys Pro Leu Gln Gly Cys Arg His Leu Leu Ala 
            20                  25                  30          


Cys Gly Thr Tyr Gln Leu Arg Arg Pro Glu Asp Arg Pro Ala Gly Pro 
        35                  40                  45              


Gln Asn Lys Gly Gly Met Glu Val Lys Glu Pro Gln Val Arg Leu Gly 
    50                  55                  60                  


Arg Leu Phe Leu Tyr Ser Phe Asn Asp Asn Asn Ser Ile His Pro Leu 
65                  70                  75                  80  


Val Glu Val Gln Arg Lys Asp Thr Ser Ala Ile Leu Asp Met Lys Trp 
                85                  90                  95      


Cys His Ile Pro Val Ala Gly His Ala Leu Leu Gly Leu Ala Asp Ala 
            100                 105                 110         


Ser Gly Ser Ile Gln Leu Leu Arg Leu Val Glu Ser Glu Lys Ser His 
        115                 120                 125             


Val Leu Glu Pro Leu Ser Ser Leu Ala Leu Glu Glu Gln Cys Leu Ala 
    130                 135                 140                 


Leu Ser Leu Asp Trp Ser Thr Gly Lys Thr Gly Arg Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Leu Lys Ile Ile Ser Ser Asp Ser Thr Gly Gln Leu His Leu Leu 
                165                 170                 175     


Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
            180                 185                 190         


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
        195                 200                 205             


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
    210                 215                 220                 


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Arg His Thr Met 
225                 230                 235                 240 


Gly Val Cys Ser Ile Gln Ser Ser Pro His Arg Glu His Ile Leu Ala 
                245                 250                 255     


Thr Gly Ser Tyr Asp Glu His Ile Leu Leu Trp Asp Thr Arg Asn Met 
            260                 265                 270         


Lys Gln Pro Leu Ala Asp Thr Pro Val Gln Gly Gly Val Trp Arg Ile 
        275                 280                 285             


Lys Trp His Pro Phe His His His Leu Leu Leu Ala Ala Cys Met His 
    290                 295                 300                 


Ser Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Met Ala Val Glu Glu 
305                 310                 315                 320 


Val Leu Leu Ala Arg Val Asp Val Leu Ser Asp Cys Trp Met Lys Asp 
                325                 330                 335     


<210>  110
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Met Gly Cys Phe Ala Leu Gln Thr Val Asp Thr Glu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Val Glu Trp Cys Pro Leu Gln Gly Cys Arg His Leu Leu Ala 
            20                  25                  30          


Cys Gly Thr Tyr Gln Leu Arg Arg Pro Glu Asp Arg Pro Ala Gly Pro 
        35                  40                  45              


Gln Asn Lys Gly Gly Met Glu Val Lys Glu Pro Gln Val Arg Leu Gly 
    50                  55                  60                  


Arg Leu Phe Leu Tyr Ser Phe Asn Asp Asn Asn Ser Ile His Pro Leu 
65                  70                  75                  80  


Val Glu Val Gln Arg Lys Asp Thr Ser Ala Ile Leu Asp Met Lys Trp 
                85                  90                  95      


Cys His Ile Pro Val Ala Gly His Ala Leu Leu Gly Leu Ala Asp Ala 
            100                 105                 110         


Ser Gly Ser Ile Gln Leu Leu Arg Leu Val Glu Ser Glu Lys Ser His 
        115                 120                 125             


Val Leu Glu Pro Leu Ser Ser Leu Ala Leu Glu Glu Gln Cys Leu Ala 
    130                 135                 140                 


Leu Ser Leu Asp Trp Ser Thr Gly Lys Thr Gly Arg Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Leu Lys Ile Ile Ser Ser Asp Ser Thr Gly Gln Leu His Leu Leu 
                165                 170                 175     


Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
            180                 185                 190         


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
        195                 200                 205             


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
    210                 215                 220                 


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Arg His Thr Met 
225                 230                 235                 240 


Gly Val Cys Ser Ile Gln Ser Ser Pro His Arg Glu His Ile Leu Ala 
                245                 250                 255     


Thr Gly Ser Tyr Asp Glu His Ile Leu Leu Trp Asp Thr Arg Asn Met 
            260                 265                 270         


Lys Gln Pro Leu Ala Asp Thr Pro Val Gln Gly Gly Val Trp Arg Ile 
        275                 280                 285             


Lys Trp His Pro Phe His His His Leu Leu Leu Ala Ala Cys Met His 
    290                 295                 300                 


Ser Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Met Gly Cys Gly Ser 
305                 310                 315                 320 


Leu Arg Ala 
            


<210>  111
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Pro Ser Trp Ala Trp Gln Met Pro Val Asp Pro Tyr Asn Cys Ser 
1               5                   10                  15      


Ala Trp Trp Asn Leu Arg Ala Gly Asp Gln Pro Leu Lys Ile Ile Ser 
            20                  25                  30          


Ser Asp Ser Thr Gly Gln Leu His Leu Leu Met Val Asn Glu Thr Arg 
        35                  40                  45              


Pro Arg Leu Gln Lys Val Ala Ser Trp Gln Ala His Gln Phe Glu Ala 
    50                  55                  60                  


Trp Ile Ala Ala Phe Asn Tyr Trp His Pro Glu Ile Val Tyr Ser Gly 
65                  70                  75                  80  


Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp Thr Arg Val Pro Gly Lys 
                85                  90                  95      


Phe Leu Phe Thr Ser Lys Arg His Thr Met Gly Val Cys Ser Ile Gln 
            100                 105                 110         


Ser Ser Pro His Arg Glu His Ile Leu Ala Thr Gly Ser Tyr Asp Glu 
        115                 120                 125             


His Ile Leu Leu Trp Asp Thr Arg Asn Met Lys Gln Pro Leu Ala Asp 
    130                 135                 140                 


Thr Pro Val Gln Gly Gly Val Trp Arg Ile Lys Trp His Pro Phe His 
145                 150                 155                 160 


His His Leu Leu Leu Ala Ala Cys Met His Ser Gly Phe Lys Ile Leu 
                165                 170                 175     


Asn Cys Gln Lys Ala Met Glu Glu Arg Gln Glu Ala Thr Val Leu Thr 
            180                 185                 190         


Ser His Thr Leu Pro Asp Ser Leu Val Tyr Gly Ala Asp Trp Ser Trp 
        195                 200                 205             


Leu Leu Phe Arg Ser Leu Gln Arg Ala Pro Ser Trp Ser Phe Pro Ser 
    210                 215                 220                 


Asn Leu Gly Thr Lys Thr Ala Asp Leu Lys Gly Ala Ser Glu Leu Pro 
225                 230                 235                 240 


Thr Pro Cys His Glu Cys Arg Glu Asp Asn Asp Gly Glu Gly His Ala 
                245                 250                 255     


Arg Pro Gln Ser Gly Met Lys Pro Leu Thr Glu Gly Met Arg Lys Asn 
            260                 265                 270         


Gly Thr Trp Leu Gln Ala Thr Ala Ala Thr Thr Arg Asp Cys Gly Val 
        275                 280                 285             


Asn Pro Glu Glu Ala Asp Ser Ala Phe Ser Leu Leu Ala Thr Cys Ser 
    290                 295                 300                 


Phe Tyr Asp His Ala Leu His Leu Trp Glu Trp Glu Gly Asn 
305                 310                 315             


<210>  112
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Met Gly Cys Phe Ala Leu Gln Thr Val Asp Thr Glu Leu Thr Ala 
1               5                   10                  15      


Asp Ser Val Glu Trp Cys Pro Leu Gln Gly Cys Arg His Leu Leu Ala 
            20                  25                  30          


Cys Gly Thr Tyr Gln Leu Arg Arg Pro Glu Asp Arg Pro Ala Gly Pro 
        35                  40                  45              


Gln Asn Lys Gly Gly Met Glu Val Lys Glu Pro Gln Val Arg Leu Gly 
    50                  55                  60                  


Arg Leu Phe Leu Tyr Ser Phe Asn Asp Asn Asn Ser Ile His Pro Leu 
65                  70                  75                  80  


Val Glu Val Gln Arg Lys Asp Thr Ser Ala Ile Leu Asp Met Lys Trp 
                85                  90                  95      


Cys His Ile Pro Val Ala Gly His Ala Leu Leu Gly Leu Ala Asp Ala 
            100                 105                 110         


Ser Gly Ser Ile Gln Leu Leu Arg Leu Val Glu Ser Glu Lys Ser His 
        115                 120                 125             


Val Leu Glu Pro Leu Ser Ser Leu Ala Leu Glu Glu Gln Cys Leu Ala 
    130                 135                 140                 


Leu Ser Leu Asp Trp Ser Thr Gly Lys Thr Gly Arg Ala Gly Asp Gln 
145                 150                 155                 160 


Pro Leu Lys Ile Ile Ser Ser Asp Ser Thr Gly Gln Leu His Leu Leu 
                165                 170                 175     


Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
            180                 185                 190         


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
        195                 200                 205             


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
    210                 215                 220                 


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Ser Tyr Asp Glu 
225                 230                 235                 240 


His Ile Leu Leu Trp Asp Thr Arg Asn Met Lys Gln Pro Leu Ala Asp 
                245                 250                 255     


Thr Pro Val Gln Gly Gly Val Trp Arg Ile Lys Trp His Pro Phe His 
            260                 265                 270         


His His Leu Leu Leu Ala Ala Cys Met His Ser Gly Phe Lys Ile Leu 
        275                 280                 285             


Asn Cys Gln Lys Ala Met Gly Cys Gly Ser Leu Arg Ala 
    290                 295                 300     


<210>  113
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
1               5                   10                  15      


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
            20                  25                  30          


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
        35                  40                  45              


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Arg His Thr Met 
    50                  55                  60                  


Gly Val Cys Ser Ile Gln Ser Ser Pro His Arg Glu His Ile Leu Ala 
65                  70                  75                  80  


Thr Gly Ser Tyr Asp Glu His Ile Leu Leu Trp Asp Thr Arg Asn Met 
                85                  90                  95      


Lys Gln Pro Leu Ala Asp Thr Pro Val Gln Gly Gly Val Trp Arg Ile 
            100                 105                 110         


Lys Trp His Pro Phe His His His Leu Leu Leu Ala Ala Cys Met His 
        115                 120                 125             


Ser Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Met Glu Glu Arg Gln 
    130                 135                 140                 


Glu Ala Thr Val Leu Thr Ser His Thr Leu Pro Asp Ser Leu Val Tyr 
145                 150                 155                 160 


Gly Ala Asp Trp Ser Trp Leu Leu Phe Arg Ser Leu Gln Arg Ala Pro 
                165                 170                 175     


Ser Trp Ser Phe Pro Ser Asn Leu Gly Thr Lys Thr Ala Asp Leu Lys 
            180                 185                 190         


Gly Ala Ser Glu Leu Pro Thr Pro Cys His Glu Cys Arg Glu Asp Asn 
        195                 200                 205             


Asp Gly Glu Gly His Ala Arg Pro Gln Ser Gly Met Lys Pro Leu Thr 
    210                 215                 220                 


Glu Gly Met Arg Lys Asn Gly Thr Trp Leu Gln Ala Thr Ala Ala Thr 
225                 230                 235                 240 


Thr Arg Asp Cys Gly Val Asn Pro Glu Glu Ala Asp Ser Ala Phe Ser 
                245                 250                 255     


Leu Leu Ala Thr Cys Ser Phe Tyr Asp His Ala Leu His Leu Trp Glu 
            260                 265                 270         


Trp Glu Gly Asn 
        275     


<210>  114
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Val Asn Glu Thr Arg Pro Arg Leu Gln Lys Val Ala Ser Trp Gln 
1               5                   10                  15      


Ala His Gln Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp His Pro 
            20                  25                  30          


Glu Ile Val Tyr Ser Gly Gly Asp Asp Gly Leu Leu Arg Gly Trp Asp 
        35                  40                  45              


Thr Arg Val Pro Gly Lys Phe Leu Phe Thr Ser Lys Ser Tyr Asp Glu 
    50                  55                  60                  


His Ile Leu Leu Trp Asp Thr Arg Asn Met Lys Gln Pro Leu Ala Asp 
65                  70                  75                  80  


Thr Pro Val Gln Gly Gly Val Trp Arg Ile Lys Trp His Pro Phe His 
                85                  90                  95      


His His Leu Leu Leu Ala Ala Cys Met His Ser Gly Phe Lys Ile Leu 
            100                 105                 110         


Asn Cys Gln Lys Ala Met Glu Glu Arg Gln Glu Ala Thr Val Leu Thr 
        115                 120                 125             


Ser His Thr Leu Pro Asp Ser Leu Val Tyr Gly Ala Asp Trp Ser Trp 
    130                 135                 140                 


Leu Leu Phe Arg Ser Leu Gln Arg Ala Pro Ser Trp Ser Phe Pro Ser 
145                 150                 155                 160 


Asn Leu Gly Thr Lys Thr Ala Asp Leu Lys Gly Ala Ser Glu Leu Pro 
                165                 170                 175     


Thr Pro Cys His Glu Cys Arg Glu Asp Asn Asp Gly Glu Gly His Ala 
            180                 185                 190         


Arg Pro Gln Ser Gly Met Lys Pro Leu Thr Glu Gly Met Arg Lys Asn 
        195                 200                 205             


Gly Thr Trp Leu Gln Ala Thr Ala Ala Thr Thr Arg Asp Cys Gly Val 
    210                 215                 220                 


Asn Pro Glu Glu Ala Asp Ser Ala Phe Ser Leu Leu Ala Thr Cys Ser 
225                 230                 235                 240 


Phe Tyr Asp His Ala Leu His Leu Trp Glu Trp Glu Gly Asn 
                245                 250                 


<210>  115
<211>  1434
<212>  DNA
<213>  Mus musculus

<400>  115
atggcgggta gccacgcagg gacgttgcga gtcctgcagg cagtagacac tgagcttacc       60

gcggactcgg tggaatggtg cccagtagaa ggttaccagc atctgctggc ctgcggaacc      120

taccagctgc gagcgcccag ggaccagcct gcactggatg gcagtgagcc tcaagttcgt      180

ttaggtcgtc tctacctgtt cagcttcagt gagcacaaca cggctaaacc tctgcttgag      240

gtccaaagaa gggactcttc tgctgtcctg gacatgaaat ggtgccacat cccagtctct      300

ggccatgtgc ttttaggctt ggcaaacgcc agtggatcca tagggctgct ccgcctgatg      360

gaatgtgaga acaacagtta caccctgcag ccaatatcca gcctcgccct ggatgagaat      420

tgtctgtcct tgtcaatgga ttggtccact gggaaatctg tcagggccag agaacagccc      480

ttgaagatca ttagcagtga ttctaagggg cagttgcacc tcctgatggt gaatgagggc      540

acagctgaac tacagctagt agcatcttgg ccagcccatc actttgaggc ctggattgct      600

gctttcaatt actggcagac agaactcgtg tattcagggg gagatgactg ccttctgaga      660

ggctgggaca ctaggatgct gggcacacct gtcttcacta gcaaaagaca ttgcatgggt      720

gtgtgcagca tccagagcag cccccatcag gagcatatac tggcaactgg aagctatgat      780

gagcatgttc tgctgtggga cactcgaaac ataagacagc cattggcgga tgtaccagtg      840

caaggaggtg tgtggaggct caagtggcac ccagttcacc accatctact cctggcggcc      900

tgcatgcaca atggcttcaa gattctcaac tgccagaagg ccattgagga gaagcaggac      960

ataactgttt taacatccca cgaaatgcct aactcattag tatatggggc tgactggtcc     1020

tggcttttcc attccatgaa gcccactcct acctggttct ttgatcagaa tgacatggga     1080

gtcaaagcag cagaccactc tagcctaaag gtcacagagg agccaccaat acattctcag     1140

gaacaaacca tggatcgcca agtggaaggc cccgctaacg ctcataccag agctgaactg     1200

aaggcttctc tccttccatt aacagaggac atgaaaaaca gcaaagactg ctcctcatcc     1260

tcagtcaaga ctcgtgatct tagccactgc tctggtgggc agagctttga caatagcctc     1320

ctggccacct gctcctttta tgaccatgtt ctccaccttt ggaagtggga gacgaatcaa     1380

gctcgcactc tttgcagtgg cactggatgt gatttgggga gtgctgacca ttga           1434


<210>  116
<211>  1068
<212>  DNA
<213>  Mus musculus

<400>  116
atgaacaaca gttacaccct gcagccaata tccagcctcg ccctggatga gaattgtctg       60

tccttgtcaa tggattggtc cactgggaaa tctgtcaggg ccagagaaca gcccttgaag      120

atcattagca gtgattctaa ggggcagttg cacctcctga tggtgaatga gggcacagct      180

gaactacagc tagtagcatc ttggccagcc catcactttg aggcctggat tgctgctttc      240

aattactggc agacagaact cgtgtattca gggggagatg actgccttct gagaggctgg      300

gacactagga tgctgggcac acctgtcttc actagcaaaa gacattgcat gggtgtgtgc      360

agcatccaga gcagccccca tcaggagcat atactggcaa ctggaagcta tgatgagcat      420

gttctgctgt gggacactcg aaacataaga cagccattgg cggatgtacc agtgcaagga      480

ggtgtgtgga ggctcaagtg gcacccagtt caccaccatc tactcctggc ggcctgcatg      540

cacaatggct tcaagattct caactgccag aaggccattg aggagaagca ggacataact      600

gttttaacat cccacgaaat gcctaactca ttagtatatg gggctgactg gtcctggctt      660

ttccattcca tgaagcccac tcctacctgg ttctttgatc agaatgacat gggagtcaaa      720

gcagcagacc actctagcct aaaggtcaca gaggagccac caatacattc tcaggaacaa      780

accatggatc gccaagtgga aggccccgct aacgctcata ccagagctga actgaaggct      840

tctctccttc cattaacaga ggacatgaaa aacagcaaag actgctcctc atcctcagtc      900

aagactcgtg atcttagcca ctgctctggt gggcagagct ttgacaatag cctcctggcc      960

acctgctcct tttatgacca tgttctccac ctttggaagt gggagacgaa tcaagctcgc     1020

actctttgca gtggcactgg atgtgatttg gggagtgctg accattga                  1068


<210>  117
<211>  999
<212>  DNA
<213>  Mus musculus

<400>  117
atggattggt ccactgggaa atctgtcagg gccagagaac agcccttgaa gatcattagc       60

agtgattcta aggggcagtt gcacctcctg atggtgaatg agggcacagc tgaactacag      120

ctagtagcat cttggccagc ccatcacttt gaggcctgga ttgctgcttt caattactgg      180

cagacagaac tcgtgtattc agggggagat gactgccttc tgagaggctg ggacactagg      240

atgctgggca cacctgtctt cactagcaaa agacattgca tgggtgtgtg cagcatccag      300

agcagccccc atcaggagca tatactggca actggaagct atgatgagca tgttctgctg      360

tgggacactc gaaacataag acagccattg gcggatgtac cagtgcaagg aggtgtgtgg      420

aggctcaagt ggcacccagt tcaccaccat ctactcctgg cggcctgcat gcacaatggc      480

ttcaagattc tcaactgcca gaaggccatt gaggagaagc aggacataac tgttttaaca      540

tcccacgaaa tgcctaactc attagtatat ggggctgact ggtcctggct tttccattcc      600

atgaagccca ctcctacctg gttctttgat cagaatgaca tgggagtcaa agcagcagac      660

cactctagcc taaaggtcac agaggagcca ccaatacatt ctcaggaaca aaccatggat      720

cgccaagtgg aaggccccgc taacgctcat accagagctg aactgaaggc ttctctcctt      780

ccattaacag aggacatgaa aaacagcaaa gactgctcct catcctcagt caagactcgt      840

gatcttagcc actgctctgg tgggcagagc tttgacaata gcctcctggc cacctgctcc      900

ttttatgacc atgttctcca cctttggaag tgggagacga atcaagctcg cactctttgc      960

agtggcactg gatgtgattt ggggagtgct gaccattga                             999


<210>  118
<211>  999
<212>  DNA
<213>  Mus musculus

<400>  118
atggattggt ccactgggaa atctgtcagg gccagagaac agcccttgaa gatcattagc       60

agtgattcta aggggcagtt gcacctcctg atggtgaatg agggcacagc tgaactacag      120

ctagtagcat cttggccagc ccatcacttt gaggcctgga ttgctgcttt caattactgg      180

cagacagaac tcgtgtattc agggggagat gactgccttc tgagaggctg ggacactagg      240

atgctgggca cacctgtctt cactagcaaa agacattgca tgggtgtgtg cagcatccag      300

agcagccccc atcaggagca tatactggca actggaagct atgatgagca tgttctgctg      360

tgggacactc gaaacataag acagccattg gcggatgtac cagtgcaagg aggtgtgtgg      420

aggctcaagt ggcacccagt tcaccaccat ctactcctgg cggcctgcat gcacaatggc      480

ttcaagattc tcaactgcca gaaggccatt gaggagaagc aggacataac tgttttaaca      540

tcccacgaaa tgcctaactc attagtatat ggggctgact ggtcctggct tttccattcc      600

atgaagccca ctcctacctg gttctttgat cagaatgaca tgggagtcaa agcagcagac      660

cactctagcc taaaggtcac agaggagcca ccaatacatt ctcaggaaca aaccatggat      720

cgccaagtgg aaggccccgc taacgctcat accagagctg aactgaaggc ttctctcctt      780

ccattaacag aggacatgaa aaacagcaaa gactgctcct catcctcagt caagactcgt      840

gatcttagcc actgctctgg tgggcagagc tttgacaata gcctcctggc cacctgctcc      900

ttttatgacc atgttctcca cctttggaag tgggagacga atcaagctcg cactctttgc      960

agtggcactg gatgtgattt ggggagtgct gaccattga                             999


<210>  119
<211>  999
<212>  DNA
<213>  Mus musculus

<400>  119
atggattggt ccactgggaa atctgtcagg gccagagaac agcccttgaa gatcattagc       60

agtgattcta aggggcagtt gcacctcctg atggtgaatg agggcacagc tgaactacag      120

ctagtagcat cttggccagc ccatcacttt gaggcctgga ttgctgcttt caattactgg      180

cagacagaac tcgtgtattc agggggagat gactgccttc tgagaggctg ggacactagg      240

atgctgggca cacctgtctt cactagcaaa agacattgca tgggtgtgtg cagcatccag      300

agcagccccc atcaggagca tatactggca actggaagct atgatgagca tgttctgctg      360

tgggacactc gaaacataag acagccattg gcggatgtac cagtgcaagg aggtgtgtgg      420

aggctcaagt ggcacccagt tcaccaccat ctactcctgg cggcctgcat gcacaatggc      480

ttcaagattc tcaactgcca gaaggccatt gaggagaagc aggacataac tgttttaaca      540

tcccacgaaa tgcctaactc attagtatat ggggctgact ggtcctggct tttccattcc      600

atgaagccca ctcctacctg gttctttgat cagaatgaca tgggagtcaa agcagcagac      660

cactctagcc taaaggtcac agaggagcca ccaatacatt ctcaggaaca aaccatggat      720

cgccaagtgg aaggccccgc taacgctcat accagagctg aactgaaggc ttctctcctt      780

ccattaacag aggacatgaa aaacagcaaa gactgctcct catcctcagt caagactcgt      840

gatcttagcc actgctctgg tgggcagagc tttgacaata gcctcctggc cacctgctcc      900

ttttatgacc atgttctcca cctttggaag tgggagacga atcaagctcg cactctttgc      960

agtggcactg gatgtgattt ggggagtgct gaccattga                             999


<210>  120
<211>  999
<212>  DNA
<213>  Mus musculus

<400>  120
atggattggt ccactgggaa atctgtcagg gccagagaac agcccttgaa gatcattagc       60

agtgattcta aggggcagtt gcacctcctg atggtgaatg agggcacagc tgaactacag      120

ctagtagcat cttggccagc ccatcacttt gaggcctgga ttgctgcttt caattactgg      180

cagacagaac tcgtgtattc agggggagat gactgccttc tgagaggctg ggacactagg      240

atgctgggca cacctgtctt cactagcaaa agacattgca tgggtgtgtg cagcatccag      300

agcagccccc atcaggagca tatactggca actggaagct atgatgagca tgttctgctg      360

tgggacactc gaaacataag acagccattg gcggatgtac cagtgcaagg aggtgtgtgg      420

aggctcaagt ggcacccagt tcaccaccat ctactcctgg cggcctgcat gcacaatggc      480

ttcaagattc tcaactgcca gaaggccatt gaggagaagc aggacataac tgttttaaca      540

tcccacgaaa tgcctaactc attagtatat ggggctgact ggtcctggct tttccattcc      600

atgaagccca ctcctacctg gttctttgat cagaatgaca tgggagtcaa agcagcagac      660

cactctagcc taaaggtcac agaggagcca ccaatacatt ctcaggaaca aaccatggat      720

cgccaagtgg aaggccccgc taacgctcat accagagctg aactgaaggc ttctctcctt      780

ccattaacag aggacatgaa aaacagcaaa gactgctcct catcctcagt caagactcgt      840

gatcttagcc actgctctgg tgggcagagc tttgacaata gcctcctggc cacctgctcc      900

ttttatgacc atgttctcca cctttggaag tgggagacga atcaagctcg cactctttgc      960

agtggcactg gatgtgattt ggggagtgct gaccattga                             999


<210>  121
<211>  849
<212>  DNA
<213>  Mus musculus

<400>  121
atgagaattg tctgtccttg tcaatggatt ggtccactgg gaaatctgtc agggggagat       60

gactgccttc tgagaggctg ggacactagg atgctgggca cacctgtctt cactagcaaa      120

agacattgca tgggtgtgtg cagcatccag agcagccccc atcaggagca tatactggca      180

actggaagct atgatgagca tgttctgctg tgggacactc gaaacataag acagccattg      240

gcggatgtac cagtgcaagg aggtgtgtgg aggctcaagt ggcacccagt tcaccaccat      300

ctactcctgg cggcctgcat gcacaatggc ttcaagattc tcaactgcca gaaggccatt      360

gaggagaagc aggacataac tgttttaaca tcccacgaaa tgcctaactc attagtatat      420

ggggctgact ggtcctggct tttccattcc atgaagccca ctcctacctg gttctttgat      480

cagaatgaca tgggagtcaa agcagcagac cactctagcc taaaggtcac agaggagcca      540

ccaatacatt ctcaggaaca aaccatggat cgccaagtgg aaggccccgc taacgctcat      600

accagagctg aactgaaggc ttctctcctt ccattaacag aggacatgaa aaacagcaaa      660

gactgctcct catcctcagt caagactcgt gatcttagcc actgctctgg tgggcagagc      720

tttgacaata gcctcctggc cacctgctcc ttttatgacc atgttctcca cctttggaag      780

tgggagacga atcaagctcg cactctttgc agtggcactg gatgtgattt ggggagtgct      840

gaccattga                                                              849


<210>  122
<211>  524
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: SL-401 DRT88-IL3 
       conjugate amino acid sequence"

<400>  122

Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr Arg Pro His Met Ala Pro Met Thr Gln Thr Thr Ser Leu 
385                 390                 395                 400 


Lys Thr Ser Trp Val Asn Cys Ser Asn Met Ile Asp Glu Ile Ile Thr 
                405                 410                 415     


His Leu Lys Gln Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn 
            420                 425                 430         


Gly Glu Asp Gln Asp Ile Leu Met Glu Asn Asn Leu Arg Arg Pro Asn 
        435                 440                 445             


Leu Glu Ala Phe Asn Arg Ala Val Lys Ser Leu Gln Asn Ala Ser Ala 
    450                 455                 460                 


Ile Glu Ser Ile Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr 
465                 470                 475                 480 


Ala Ala Pro Thr Arg His Pro Ile His Ile Lys Asp Gly Asp Trp Asn 
                485                 490                 495     


Glu Phe Arg Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala 
            500                 505                 510         


Gln Ala Gln Gln Thr Thr Leu Ser Leu Ala Ile Phe 
        515                 520                 


<210>  123
<211>  819
<212>  DNA
<213>  Mus musculus

<400>  123
atggacttct gtcttcccac agggggagat gactgccttc tgagaggctg ggacactagg       60

atgctgggca cacctgtctt cactagcaaa agacattgca tgggtgtgtg cagcatccag      120

agcagccccc atcaggagca tatactggca actggaagct atgatgagca tgttctgctg      180

tgggacactc gaaacataag acagccattg gcggatgtac cagtgcaagg aggtgtgtgg      240

aggctcaagt ggcacccagt tcaccaccat ctactcctgg cggcctgcat gcacaatggc      300

ttcaagattc tcaactgcca gaaggccatt gaggagaagc aggacataac tgttttaaca      360

tcccacgaaa tgcctaactc attagtatat ggggctgact ggtcctggct tttccattcc      420

atgaagccca ctcctacctg gttctttgat cagaatgaca tgggagtcaa agcagcagac      480

cactctagcc taaaggtcac agaggagcca ccaatacatt ctcaggaaca aaccatggat      540

cgccaagtgg aaggccccgc taacgctcat accagagctg aactgaaggc ttctctcctt      600

ccattaacag aggacatgaa aaacagcaaa gactgctcct catcctcagt caagactcgt      660

gatcttagcc actgctctgg tgggcagagc tttgacaata gcctcctggc cacctgctcc      720

ttttatgacc atgttctcca cctttggaag tgggagacga atcaagctcg cactctttgc      780

agtggcactg gatgtgattt ggggagtgct gaccattga                             819


<210>  124
<211>  477
<212>  PRT
<213>  Mus musculus

<400>  124

Met Ala Gly Ser His Ala Gly Thr Leu Arg Val Leu Gln Ala Val Asp 
1               5                   10                  15      


Thr Glu Leu Thr Ala Asp Ser Val Glu Trp Cys Pro Val Glu Gly Tyr 
            20                  25                  30          


Gln His Leu Leu Ala Cys Gly Thr Tyr Gln Leu Arg Ala Pro Arg Asp 
        35                  40                  45              


Gln Pro Ala Leu Asp Gly Ser Glu Pro Gln Val Arg Leu Gly Arg Leu 
    50                  55                  60                  


Tyr Leu Phe Ser Phe Ser Glu His Asn Thr Ala Lys Pro Leu Leu Glu 
65                  70                  75                  80  


Val Gln Arg Arg Asp Ser Ser Ala Val Leu Asp Met Lys Trp Cys His 
                85                  90                  95      


Ile Pro Val Ser Gly His Val Leu Leu Gly Leu Ala Asn Ala Ser Gly 
            100                 105                 110         


Ser Ile Gly Leu Leu Arg Leu Met Glu Cys Glu Asn Asn Ser Tyr Thr 
        115                 120                 125             


Leu Gln Pro Ile Ser Ser Leu Ala Leu Asp Glu Asn Cys Leu Ser Leu 
    130                 135                 140                 


Ser Met Asp Trp Ser Thr Gly Lys Ser Val Arg Ala Arg Glu Gln Pro 
145                 150                 155                 160 


Leu Lys Ile Ile Ser Ser Asp Ser Lys Gly Gln Leu His Leu Leu Met 
                165                 170                 175     


Val Asn Glu Gly Thr Ala Glu Leu Gln Leu Val Ala Ser Trp Pro Ala 
            180                 185                 190         


His His Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp Gln Thr Glu 
        195                 200                 205             


Leu Val Tyr Ser Gly Gly Asp Asp Cys Leu Leu Arg Gly Trp Asp Thr 
    210                 215                 220                 


Arg Met Leu Gly Thr Pro Val Phe Thr Ser Lys Arg His Cys Met Gly 
225                 230                 235                 240 


Val Cys Ser Ile Gln Ser Ser Pro His Gln Glu His Ile Leu Ala Thr 
                245                 250                 255     


Gly Ser Tyr Asp Glu His Val Leu Leu Trp Asp Thr Arg Asn Ile Arg 
            260                 265                 270         


Gln Pro Leu Ala Asp Val Pro Val Gln Gly Gly Val Trp Arg Leu Lys 
        275                 280                 285             


Trp His Pro Val His His His Leu Leu Leu Ala Ala Cys Met His Asn 
    290                 295                 300                 


Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Ile Glu Glu Lys Gln Asp 
305                 310                 315                 320 


Ile Thr Val Leu Thr Ser His Glu Met Pro Asn Ser Leu Val Tyr Gly 
                325                 330                 335     


Ala Asp Trp Ser Trp Leu Phe His Ser Met Lys Pro Thr Pro Thr Trp 
            340                 345                 350         


Phe Phe Asp Gln Asn Asp Met Gly Val Lys Ala Ala Asp His Ser Ser 
        355                 360                 365             


Leu Lys Val Thr Glu Glu Pro Pro Ile His Ser Gln Glu Gln Thr Met 
    370                 375                 380                 


Asp Arg Gln Val Glu Gly Pro Ala Asn Ala His Thr Arg Ala Glu Leu 
385                 390                 395                 400 


Lys Ala Ser Leu Leu Pro Leu Thr Glu Asp Met Lys Asn Ser Lys Asp 
                405                 410                 415     


Cys Ser Ser Ser Ser Val Lys Thr Arg Asp Leu Ser His Cys Ser Gly 
            420                 425                 430         


Gly Gln Ser Phe Asp Asn Ser Leu Leu Ala Thr Cys Ser Phe Tyr Asp 
        435                 440                 445             


His Val Leu His Leu Trp Lys Trp Glu Thr Asn Gln Ala Arg Thr Leu 
    450                 455                 460                 


Cys Ser Gly Thr Gly Cys Asp Leu Gly Ser Ala Asp His 
465                 470                 475         


<210>  125
<211>  355
<212>  PRT
<213>  Mus musculus

<400>  125

Met Asn Asn Ser Tyr Thr Leu Gln Pro Ile Ser Ser Leu Ala Leu Asp 
1               5                   10                  15      


Glu Asn Cys Leu Ser Leu Ser Met Asp Trp Ser Thr Gly Lys Ser Val 
            20                  25                  30          


Arg Ala Arg Glu Gln Pro Leu Lys Ile Ile Ser Ser Asp Ser Lys Gly 
        35                  40                  45              


Gln Leu His Leu Leu Met Val Asn Glu Gly Thr Ala Glu Leu Gln Leu 
    50                  55                  60                  


Val Ala Ser Trp Pro Ala His His Phe Glu Ala Trp Ile Ala Ala Phe 
65                  70                  75                  80  


Asn Tyr Trp Gln Thr Glu Leu Val Tyr Ser Gly Gly Asp Asp Cys Leu 
                85                  90                  95      


Leu Arg Gly Trp Asp Thr Arg Met Leu Gly Thr Pro Val Phe Thr Ser 
            100                 105                 110         


Lys Arg His Cys Met Gly Val Cys Ser Ile Gln Ser Ser Pro His Gln 
        115                 120                 125             


Glu His Ile Leu Ala Thr Gly Ser Tyr Asp Glu His Val Leu Leu Trp 
    130                 135                 140                 


Asp Thr Arg Asn Ile Arg Gln Pro Leu Ala Asp Val Pro Val Gln Gly 
145                 150                 155                 160 


Gly Val Trp Arg Leu Lys Trp His Pro Val His His His Leu Leu Leu 
                165                 170                 175     


Ala Ala Cys Met His Asn Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala 
            180                 185                 190         


Ile Glu Glu Lys Gln Asp Ile Thr Val Leu Thr Ser His Glu Met Pro 
        195                 200                 205             


Asn Ser Leu Val Tyr Gly Ala Asp Trp Ser Trp Leu Phe His Ser Met 
    210                 215                 220                 


Lys Pro Thr Pro Thr Trp Phe Phe Asp Gln Asn Asp Met Gly Val Lys 
225                 230                 235                 240 


Ala Ala Asp His Ser Ser Leu Lys Val Thr Glu Glu Pro Pro Ile His 
                245                 250                 255     


Ser Gln Glu Gln Thr Met Asp Arg Gln Val Glu Gly Pro Ala Asn Ala 
            260                 265                 270         


His Thr Arg Ala Glu Leu Lys Ala Ser Leu Leu Pro Leu Thr Glu Asp 
        275                 280                 285             


Met Lys Asn Ser Lys Asp Cys Ser Ser Ser Ser Val Lys Thr Arg Asp 
    290                 295                 300                 


Leu Ser His Cys Ser Gly Gly Gln Ser Phe Asp Asn Ser Leu Leu Ala 
305                 310                 315                 320 


Thr Cys Ser Phe Tyr Asp His Val Leu His Leu Trp Lys Trp Glu Thr 
                325                 330                 335     


Asn Gln Ala Arg Thr Leu Cys Ser Gly Thr Gly Cys Asp Leu Gly Ser 
            340                 345                 350         


Ala Asp His 
        355 


<210>  126
<211>  332
<212>  PRT
<213>  Mus musculus

<400>  126

Met Asp Trp Ser Thr Gly Lys Ser Val Arg Ala Arg Glu Gln Pro Leu 
1               5                   10                  15      


Lys Ile Ile Ser Ser Asp Ser Lys Gly Gln Leu His Leu Leu Met Val 
            20                  25                  30          


Asn Glu Gly Thr Ala Glu Leu Gln Leu Val Ala Ser Trp Pro Ala His 
        35                  40                  45              


His Phe Glu Ala Trp Ile Ala Ala Phe Asn Tyr Trp Gln Thr Glu Leu 
    50                  55                  60                  


Val Tyr Ser Gly Gly Asp Asp Cys Leu Leu Arg Gly Trp Asp Thr Arg 
65                  70                  75                  80  


Met Leu Gly Thr Pro Val Phe Thr Ser Lys Arg His Cys Met Gly Val 
                85                  90                  95      


Cys Ser Ile Gln Ser Ser Pro His Gln Glu His Ile Leu Ala Thr Gly 
            100                 105                 110         


Ser Tyr Asp Glu His Val Leu Leu Trp Asp Thr Arg Asn Ile Arg Gln 
        115                 120                 125             


Pro Leu Ala Asp Val Pro Val Gln Gly Gly Val Trp Arg Leu Lys Trp 
    130                 135                 140                 


His Pro Val His His His Leu Leu Leu Ala Ala Cys Met His Asn Gly 
145                 150                 155                 160 


Phe Lys Ile Leu Asn Cys Gln Lys Ala Ile Glu Glu Lys Gln Asp Ile 
                165                 170                 175     


Thr Val Leu Thr Ser His Glu Met Pro Asn Ser Leu Val Tyr Gly Ala 
            180                 185                 190         


Asp Trp Ser Trp Leu Phe His Ser Met Lys Pro Thr Pro Thr Trp Phe 
        195                 200                 205             


Phe Asp Gln Asn Asp Met Gly Val Lys Ala Ala Asp His Ser Ser Leu 
    210                 215                 220                 


Lys Val Thr Glu Glu Pro Pro Ile His Ser Gln Glu Gln Thr Met Asp 
225                 230                 235                 240 


Arg Gln Val Glu Gly Pro Ala Asn Ala His Thr Arg Ala Glu Leu Lys 
                245                 250                 255     


Ala Ser Leu Leu Pro Leu Thr Glu Asp Met Lys Asn Ser Lys Asp Cys 
            260                 265                 270         


Ser Ser Ser Ser Val Lys Thr Arg Asp Leu Ser His Cys Ser Gly Gly 
        275                 280                 285             


Gln Ser Phe Asp Asn Ser Leu Leu Ala Thr Cys Ser Phe Tyr Asp His 
    290                 295                 300                 


Val Leu His Leu Trp Lys Trp Glu Thr Asn Gln Ala Arg Thr Leu Cys 
305                 310                 315                 320 


Ser Gly Thr Gly Cys Asp Leu Gly Ser Ala Asp His 
                325                 330         


<210>  127
<211>  282
<212>  PRT
<213>  Mus musculus

<400>  127

Met Arg Ile Val Cys Pro Cys Gln Trp Ile Gly Pro Leu Gly Asn Leu 
1               5                   10                  15      


Ser Gly Gly Asp Asp Cys Leu Leu Arg Gly Trp Asp Thr Arg Met Leu 
            20                  25                  30          


Gly Thr Pro Val Phe Thr Ser Lys Arg His Cys Met Gly Val Cys Ser 
        35                  40                  45              


Ile Gln Ser Ser Pro His Gln Glu His Ile Leu Ala Thr Gly Ser Tyr 
    50                  55                  60                  


Asp Glu His Val Leu Leu Trp Asp Thr Arg Asn Ile Arg Gln Pro Leu 
65                  70                  75                  80  


Ala Asp Val Pro Val Gln Gly Gly Val Trp Arg Leu Lys Trp His Pro 
                85                  90                  95      


Val His His His Leu Leu Leu Ala Ala Cys Met His Asn Gly Phe Lys 
            100                 105                 110         


Ile Leu Asn Cys Gln Lys Ala Ile Glu Glu Lys Gln Asp Ile Thr Val 
        115                 120                 125             


Leu Thr Ser His Glu Met Pro Asn Ser Leu Val Tyr Gly Ala Asp Trp 
    130                 135                 140                 


Ser Trp Leu Phe His Ser Met Lys Pro Thr Pro Thr Trp Phe Phe Asp 
145                 150                 155                 160 


Gln Asn Asp Met Gly Val Lys Ala Ala Asp His Ser Ser Leu Lys Val 
                165                 170                 175     


Thr Glu Glu Pro Pro Ile His Ser Gln Glu Gln Thr Met Asp Arg Gln 
            180                 185                 190         


Val Glu Gly Pro Ala Asn Ala His Thr Arg Ala Glu Leu Lys Ala Ser 
        195                 200                 205             


Leu Leu Pro Leu Thr Glu Asp Met Lys Asn Ser Lys Asp Cys Ser Ser 
    210                 215                 220                 


Ser Ser Val Lys Thr Arg Asp Leu Ser His Cys Ser Gly Gly Gln Ser 
225                 230                 235                 240 


Phe Asp Asn Ser Leu Leu Ala Thr Cys Ser Phe Tyr Asp His Val Leu 
                245                 250                 255     


His Leu Trp Lys Trp Glu Thr Asn Gln Ala Arg Thr Leu Cys Ser Gly 
            260                 265                 270         


Thr Gly Cys Asp Leu Gly Ser Ala Asp His 
        275                 280         


<210>  128
<211>  272
<212>  PRT
<213>  Mus musculus

<400>  128

Met Asp Phe Cys Leu Pro Thr Gly Gly Asp Asp Cys Leu Leu Arg Gly 
1               5                   10                  15      


Trp Asp Thr Arg Met Leu Gly Thr Pro Val Phe Thr Ser Lys Arg His 
            20                  25                  30          


Cys Met Gly Val Cys Ser Ile Gln Ser Ser Pro His Gln Glu His Ile 
        35                  40                  45              


Leu Ala Thr Gly Ser Tyr Asp Glu His Val Leu Leu Trp Asp Thr Arg 
    50                  55                  60                  


Asn Ile Arg Gln Pro Leu Ala Asp Val Pro Val Gln Gly Gly Val Trp 
65                  70                  75                  80  


Arg Leu Lys Trp His Pro Val His His His Leu Leu Leu Ala Ala Cys 
                85                  90                  95      


Met His Asn Gly Phe Lys Ile Leu Asn Cys Gln Lys Ala Ile Glu Glu 
            100                 105                 110         


Lys Gln Asp Ile Thr Val Leu Thr Ser His Glu Met Pro Asn Ser Leu 
        115                 120                 125             


Val Tyr Gly Ala Asp Trp Ser Trp Leu Phe His Ser Met Lys Pro Thr 
    130                 135                 140                 


Pro Thr Trp Phe Phe Asp Gln Asn Asp Met Gly Val Lys Ala Ala Asp 
145                 150                 155                 160 


His Ser Ser Leu Lys Val Thr Glu Glu Pro Pro Ile His Ser Gln Glu 
                165                 170                 175     


Gln Thr Met Asp Arg Gln Val Glu Gly Pro Ala Asn Ala His Thr Arg 
            180                 185                 190         


Ala Glu Leu Lys Ala Ser Leu Leu Pro Leu Thr Glu Asp Met Lys Asn 
        195                 200                 205             


Ser Lys Asp Cys Ser Ser Ser Ser Val Lys Thr Arg Asp Leu Ser His 
    210                 215                 220                 


Cys Ser Gly Gly Gln Ser Phe Asp Asn Ser Leu Leu Ala Thr Cys Ser 
225                 230                 235                 240 


Phe Tyr Asp His Val Leu His Leu Trp Lys Trp Glu Thr Asn Gln Ala 
                245                 250                 255     


Arg Thr Leu Cys Ser Gly Thr Gly Cys Asp Leu Gly Ser Ala Asp His 
            260                 265                 270         


<210>  129
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  129
acggaggcta agcgtcgcaa                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  130
cgcttccgcg gcccgttcaa                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  131
gtcttgaacg gaggtgtcca                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  132
agctgtgacc atagtgcacc                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  133
gttgacttcc tggtgcacta                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       targeting sequence"

<400>  134
gggttgttca ggacctcagg                                                   20