                         SEQUENCE LISTING

<110>  Tufts Medical Center, Inc.
 
<120>  Bispecific Antibody Constructs and Methods of Use

<130>  00398-0183WO1

<140>  PCT/US2018/058146
<141>  2018-10-30

<150>  US 62/580,079
<151>  2017-11-01

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  1

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  2

Tyr Thr Ser Lys Ile His Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  3

Gln Gln Gly Asn Thr Phe Pro Tyr Thr 
1               5                   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  4

Ser Phe Trp Met His 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  5

Tyr Ile Asn Pro Arg Ser Gly Tyr Thr Glu Tyr Asn Glu Ile Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  6

Phe Leu Gly Arg Gly Ala Met Asp Tyr 
1               5                   


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  7

Thr Ala Ser Ser Ser Val Ser Ser Asn Tyr Leu His 
1               5                   10          


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  8

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  9

His Gln Tyr Leu Arg Ser Pro Pro Thr 
1               5                   


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  10

Gly Phe Ser Leu Thr Asp Tyr Gly Val His 
1               5                   10  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  11

Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys Ser 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  12

His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp Tyr 
1               5                   10                  15      


<210>  13
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  14

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  15
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide;

<400>  15

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  16

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  17
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser 
            20                  25                  30  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  18

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  19

Lys Ala Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  20
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  20

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  21
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  21

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys 
            20              


<210>  22
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  22

Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Asn Leu Trp Ile Tyr 
1               5                   10                  15  


<210>  23
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  23

Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  24

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  25

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser 
            20                  25  


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  26

Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Val 
1               5                   10                  


<210>  27
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  27

Arg Met Thr Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Ile 
1               5                   10                  15      


Met Asn Ser Leu Gln Thr Asp Asp Ser Ala Met Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  28

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  29

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  30

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Thr Arg Cys 
            20  


<210>  31
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  31

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Phe Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Glu Ile Phe Arg Asp Lys Ala Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Phe Leu Gly Arg Gly Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu 
465                 470                 475                 480 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                485                 490                 495     


Thr Ile Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg 
            500                 505                 510         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Val Val Ile Trp Ser Asp 
        515                 520                 525             


Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys Ser Arg Met Thr Ile Arg 
    530                 535                 540                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Ile Met Asn Ser Leu Gln 
545                 550                 555                 560 


Thr Asp Asp Ser Ala Met Tyr Tyr Cys Ala Arg His Gly Thr Tyr Tyr 
                565                 570                 575     


Gly Met Thr Thr Thr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            580                 585                 590         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
    610                 615                 620                 


Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser 
625                 630                 635                 640 


Ser Val Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser 
                645                 650                 655     


Ala Pro Asn Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val 
            660                 665                 670         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        675                 680                 685             


Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln 
    690                 695                 700                 


Tyr Leu Arg Ser Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
705                 710                 715                 720 


Lys 
    


<210>  32
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  32

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Lys Ile His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  33

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  34

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  35

Gln Gln Arg Ser Asn Trp Pro Leu Thr 
1               5                   


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  36

Ser Ser Ser Tyr Trp Gly 
1               5       


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  37

Ser Ile Tyr Tyr Ser Gly Arg Asn Tyr Asn Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  38

His Tyr Tyr Gly Ser Gly Ser Ser Tyr Tyr Tyr Tyr Asp Leu Asp 
1               5                   10                  15  


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  39

Ser Tyr Ala Met His 
1               5   


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  40

Val Ile Ser Phe Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  41

Glu Tyr Trp Gly Thr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10          


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  42

Ser Thr Tyr Ala Met His 
1               5       


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  43

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  44

Arg Glu Ser Pro Pro Ile Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  45

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  46

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  47
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  47

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Leu Ala Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser Phe Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr Glu Tyr Asn 
65                  70                  75                  80  


Glu Ile Phe Arg Asp Lys Ala Thr Met Thr Thr Asp Thr Ser Thr Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Phe Leu Gly Arg Gly Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu 
465                 470                 475                 480 


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys 
                485                 490                 495     


Thr Ile Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg 
            500                 505                 510         


Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Val Val Ile Trp Ser Asp 
        515                 520                 525             


Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys Ser Arg Met Thr Ile Arg 
    530                 535                 540                 


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Ile Met Asn Ser Leu Gln 
545                 550                 555                 560 


Thr Asp Asp Ser Ala Met Tyr Tyr Cys Ala Arg His Gly Thr Tyr Tyr 
                565                 570                 575     


Gly Met Thr Thr Thr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr 
            580                 585                 590         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        595                 600                 605             


Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met 
    610                 615                 620                 


Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser 
625                 630                 635                 640 


Ser Val Ser Ser Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser 
                645                 650                 655     


Ala Pro Asn Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val 
            660                 665                 670         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        675                 680                 685             


Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln 
    690                 695                 700                 


Tyr Leu Arg Ser Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
705                 710                 715                 720 


Lys 
    


<210>  48
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  48

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Thr Ser Lys Ile His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn 
            100                 105                 110         


Thr Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  49
<211>  124
<212>  PRT
<213>  Mus musculus

<400>  49

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Met Thr Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Ile Met Asn Ser Leu Gln Thr Asp Asp Ser Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  50
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ile Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Met Thr Ile Ser Lys Asp Asn Ser Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  51
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ile Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Met Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  52
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  53
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ile Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Met Thr Ile Ser Lys Asp Asn Ser Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  54
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  54

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Ala Ile Ser Gly Phe Ser Leu Thr Asp Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Val Val Ile Trp Ser Asp Gly Ser Ser Thr Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Ser Arg Met Thr Ile Ser Lys Asp Asn Ser Lys Ser Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg His Gly Thr Tyr Tyr Gly Met Thr Thr Thr Gly Asp Ala Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  55
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  55

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Asn Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  56
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  56

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Met Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  57
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  57

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Met Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  58
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  59
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  59

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  60
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  60

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Asn 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  61
<211>  2171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetically generated oligonucleotide

<400>  61
gaattcgcca ccatggagct gggcctgtcc tggatcttcc tgctggccat cctgaagggc       60

gtgcagtgcc aggttcagct gcagcagtct ggaggagagc tggctaagcc tggagcttct      120

gtgaaggtga gctgtaaggc ttccggctac acctttagct ccttctggat gcactgggtg      180

cggcaggctc ctggacaggg actggagtgg attggatata tcaatccccg gtccggctac      240

accgagtata atgagatctt tcgggataag gccaccatga ccaccgacac atccacctct      300

accgcttaca tggagctgag cagcctgagg tccgaggata cagctgtgta ttactgtgct      360

tcctttctgg gccggggcgc tatggactat tggggacagg gaaccaccgt gaccgtgtcc      420

tccaccaaag gtccttccgt gtttcccctg gccccttgct ccaggtccac ctccgagtcc      480

accgctgctc tgggatgcct ggtgaaagat tacttccccg agcccgtgac cgtgtcttgg      540

aatagtggcg ctctgaccag cggcgttcac accttccctg ctgttctgca gagctccgga      600

ctgtatagcc tgtccagcgt ggtgaccgtg ccttcctcca attttggcac ccagacctac      660

acctgtaatg tggatcacaa gcccagcaac accaaggtgg acaagaccgt ggagcggaag      720

tgttgtgtgg agtgtccccc atgtcccgct cctcctgtgg ctggaccttc cgtgtttctg      780

ttccccccaa agcccaagga taccctgatg atcagcagga cccctgaggt gacctgtgtg      840

gttgtggacg tgtcccacga ggaccctgaa gttcagttca attggtacgt ggatggcgtg      900

gacgtgcaca acgctaagac caagcctcgg gaggagcagt tcaacagcac ctttagggtg      960

gtgtccgtgt tgaccgtggt gcatcaggat tggctgaacg gcaaggagta caagtgcaag     1020

gtgtccaaca agggcctgcc cgctcctatt gagaagacca tcagcaagac caagggccag     1080

cccagagagc ctcaggtgta tacactgccc ccctctaggg aggagatgac aaagaaccag     1140

gtgagcctga cctgtctggt gaagggattc tatccctccg atatcgccgt ggagtgggag     1200

tccaatggcc agcctgaaaa caactataag accacccctc ctatgctgga tagcgatggc     1260

tcctttttcc tgtacagcaa gctgaccgtg gataagagcc ggtggcagca gggaaatgtg     1320

ttttcctgtt ccgtgatgca cgaggctctg cacaaccact acacccagaa gagcctgagc     1380

ctgagccctg gaaagggagg aggaggaggc ggaggaagcc aggtgcagct gaaggagtct     1440

ggaccaggac tggtggctcc atctcagtct ctgtccatca cctgcaccat ctccggcttt     1500

tccctgaccg actatggcgt gcactgggtt aggcagcctc ctggaaaggg actggagtgg     1560

ttggtggtca tttggagcga tggcagctcc acctataact ccgctctgaa gagccggatg     1620

accatcagga aggacaacag caagagccag gtgttcctga tcatgaatag cctgcagacc     1680

gatgacagcg ccatgtacta ctgtgctagg cacggcacct attatggcat gaccaccacc     1740

ggcgacgctt tggactactg gggacaggga accagcgtga cagtgtctag cggaggagga     1800

ggatctggcg gaggaggaag cggaggagga ggatctcaga tcgtgctgac ccagagccct     1860

gctatcatgt ccgcttctct gggcgagaga gtgaccatga cctgcacagc ttccagctcc     1920

gtgagctcta attacctgca ctggtatcag cagaagcctg gcagcgctcc aaacttgtgg     1980

atctatagca ccagcaatct ggccagcggc gtgcctgcta ggttttccgg atctggatct     2040

ggcaccagct actccctgac catcagctct atggaggccg aggatgctgc cacatactat     2100

tgtcaccagt atctgaggag cccccctacc tttggcggag gaaccaaact ggagatcaag     2160

tgagcggccg c                                                          2171


<210>  62
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetically generated oligonucleotide

<400>  62
gaattcgcca ccatgcgggt gcccgcccag ctgctgggcc tgctgctgct gtggctgccc       60

ggcacccggt gcgacatcca gatgacccag agcccttcct ccctgtctgc ttctgtggga      120

gatcgggtga ccatcacctg cagagcttcc caggatatct ccaattacct ggcttggtat      180

caacagaagc ccggcaaggc tcctaagctg ttgatctact ataccagcaa gatccacagc      240

ggcgtgccct ccaggttttc tggatctgga tctggcaccg attacacctt taccatctcc      300

agcctgcagc ccgaggacat tgctacatac tactgccagc agggcaacac ctttccctac      360

accttcggcc agggcacaaa ggttgagatc aaggtggctg ctccttccgt gtttatcttc      420

ccccctagcg atgagcagct gaagtccgga accgcttccg ttgtgtgtct gctgaacaac      480

ttctatcccc gggaggccaa ggtgcagtgg aaagtggata acgccctgca gtccggcaac      540

tctcaggaat ctgtgaccga gcaggactcc aaggactcca catacagcct gagctccacc      600

ctgaccctgt ctaaggctga ctacgagaag cacaaggtgt acgcttgcga ggtgacccac      660

cagggattgt ctagccctgt gaccaagtcc ttcaatcggg gcgagtgctg aataagcggc      720

cgc                                                                    723


<210>  63
<211>  701
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  63

Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Leu Ala Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Gly Tyr Thr Glu Tyr Asn Glu Ile Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Phe Leu Gly Arg Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly 
    450                 455                 460                 


Leu Val Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Ile Ser Gly 
465                 470                 475                 480 


Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly 
                485                 490                 495     


Lys Gly Leu Glu Trp Leu Val Val Ile Trp Ser Asp Gly Ser Ser Thr 
            500                 505                 510         


Tyr Asn Ser Ala Leu Lys Ser Arg Met Thr Ile Arg Lys Asp Asn Ser 
        515                 520                 525             


Lys Ser Gln Val Phe Leu Ile Met Asn Ser Leu Gln Thr Asp Asp Ser 
    530                 535                 540                 


Ala Met Tyr Tyr Cys Ala Arg His Gly Thr Tyr Tyr Gly Met Thr Thr 
545                 550                 555                 560 


Thr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
                565                 570                 575     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            580                 585                 590         


Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Leu 
        595                 600                 605             


Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser 
    610                 615                 620                 


Asn Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Asn Leu 
625                 630                 635                 640 


Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe 
                645                 650                 655     


Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met 
            660                 665                 670         


Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr Leu Arg Ser 
        675                 680                 685             


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    690                 695                 700     


<210>  64
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  64

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Ile His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  S or T

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  S or P or T

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Q or N

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  F or S

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  T or I

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  K or T

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  G or D or S

<400>  65

Thr Leu Xaa Xaa Xaa His Xaa Xaa Tyr Xaa Ile Xaa 
1               5                   10          


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Lor I

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  N or T

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  D or H or S

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  G or S

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  S or L or T

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  H or Y

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  N or K or Q or I

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  K or T

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  G or A

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  D or S or V

<400>  66

Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  G or A

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  S or A or Y

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  S or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  S or A or Y

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  S or Y or T

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  V or I

<400>  67

Xaa Xaa Xaa Tyr Xaa Xaa Gly Tyr Xaa 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  N or A

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  I or V

<400>  68

Gly Phe Thr Phe Ser Xaa Arg Trp Xaa Tyr 
1               5                   10  


<210>  69
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  N or A or T

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  I or R

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  E or Q

<400>  69

Gly Ile Lys Thr Lys Pro Xaa Xaa Tyr Ala Thr Xaa Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  L or V

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  M or K

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  R or K

<400>  70

Xaa Thr Gly Xaa Xaa Tyr Phe Asp Tyr 
1               5                   


<210>  71
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  71

Thr Leu Ser Ser Gln His Ser Thr Tyr Thr Ile 
1               5                   10      


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  72

Leu Asn Ser Asp Ser Ser His Asn Lys Gly Ser Gly Ile Pro Asp 
1               5                   10                  15  


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  73

Ala Ala Tyr Tyr Ala Tyr Gly Tyr Val 
1               5                   


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  74

Gly Phe Thr Phe Ser Ala Arg Trp Ile Tyr 
1               5                   10  


<210>  75
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  75

Gly Ile Lys Thr Lys Pro Ala Ile Tyr Ala Thr Glu Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly Arg Phe Thr 
            20          


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  76

Leu Thr Gly Met Lys Tyr Phe Asp Tyr 
1               5                   


<210>  77
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asp Gln Ser Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  78
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Tyr Ser Asp Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Gly Asp Tyr Gly His His His Gly Leu Ser Gly Ile 
            100                 105                 110         


Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  79
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  79

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Ile Gly Glu Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gly Ser Tyr Thr Leu Thr Asn Thr Ala 
                85                  90                  95      


Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  80
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Tyr Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Glu Phe Gly Phe Met Tyr Ser Thr Leu Val Phe Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  81
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  81

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Ile Gly Glu Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Tyr Ser Ser Asp Ala 
                85                  90                  95      


Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 


<210>  82
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  82

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile His Asp Asn Gly His Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Gly Glu Phe Gly Phe Met Tyr Ser Thr Leu Val Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  83
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Pro Arg Gln Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  84
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Ala Lys Gln Ser Gly Tyr Ala Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Leu Gly Asp Tyr Gly His His His Gly Leu Ser 
            100                 105                 110         


Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  85
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Phe Gly Ile Gln Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  86
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Ala Lys Gln Ser Gly Tyr Ala Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Leu Gly Asp Tyr Gly His His His Gly Leu Ser 
            100                 105                 110         


Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  87
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Asn Pro Gln Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  88
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Phe Ile Glu Pro Lys Trp Arg Gly Gly Ala Thr His Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Leu Gly Asp Tyr Gly His His His Gly Leu Ser 
            100                 105                 110         


Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  89
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Gln Ser Gly Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asp Gln Ser Tyr Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105             


<210>  90
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetically generated peptide

<400>  90

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Arg Ala Lys Gln Ser Gly Tyr Ala Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gly Leu Gly Asp Tyr Gly His His His Gly Leu Ser 
            100                 105                 110         


Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


