                         SEQUENCE LISTING

<110>  Peking University
 
<120>  METHODS AND USE FOR DETECTING AND INHIBITING CELL-FREE MG53

<130>  066467-8002WO02

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  136
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  1

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Arg Asn Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Val Asp Phe Glu Asp Asp Arg Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Ser Ala Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Val Arg Gly Asn Pro Gly Ala Thr Arg Gly Gly Ile Ile Trp Gly Pro 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser 
    130                 135     


<210>  2
<211>  134
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  2

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ile Val Val Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Lys Ser Val Pro Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Ser Asn Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Ile Leu Ala Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Val Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Tyr Lys Tyr Arg Asp Ser Asp Asn Thr Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys 
    130                 


<210>  3
<211>  459
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Leu Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Ala Ser Gly Ile Asp Leu Ser 
        35                  40                  45              


Arg Asn Asp Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Tyr Val Asp Phe Glu Asp Asp Arg Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Val Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Ser Ala Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Val Arg Gly Asn Pro Gly Ala Thr Arg Gly Gly Ile Ile Trp Gly Pro 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val 
            180                 185                 190         


Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr 
        195                 200                 205             


Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr 
225                 230                 235                 240 


Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
        275                 280                 285             


Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
    290                 295                 300                 


Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
305                 310                 315                 320 


Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
            340                 345                 350         


Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
        355                 360                 365             


Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
385                 390                 395                 400 


Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
            420                 425                 430         


Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 


<210>  4
<211>  238
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ile Val Val Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Lys Ser Val Pro Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Ser Asn Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Ile Leu Ala Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Val Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Tyr Lys Tyr Arg Asp Ser Asp Asn Thr Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
    130                 135                 140                 


Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val 
145                 150                 155                 160 


Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val 
                165                 170                 175     


Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln 
            180                 185                 190         


Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln 
    210                 215                 220                 


Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235             


<210>  5
<211>  408
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  5
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagcctctg gaatcgacct cagtaggaat gatataaatt gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg atacgttgat tttgaggatg acagatacta cgcgagctgg      240

gtgaaaggcc gcttcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa gcgcggacac ggccacatat tactgtgtca gaggcaatcc tggcgctact      360

cgtggtggaa tcatctgggg cccaggcacc ctggtcaccg tctcctcg                   408


<210>  6
<211>  402
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  6
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgcca tcgtggtgac ccagactcca tcttccaagt ctgtccctgt gggaggcaca      120

gtcaccatca gttgccagtc cagtcagagt gtttatagta acaatcgctt agcctggtat      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatt atgcatccat tctggcatct      240

ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gatgtggtgt gtgacgatgc tgccacttac tactgtgcag gatataaata tcgtgacagt      360

gataatactg ctttcggcgg agggaccgag gtggtggtca aa                         402


<210>  7
<211>  1380
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  7
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcgctggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagcctctg gaatcgacct cagtaggaat gatataaatt gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg atacgttgat tttgaggatg acagatacta cgcgagctgg      240

gtgaaaggcc gcttcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa gcgcggacac ggccacatat tactgtgtca gaggcaatcc tggcgctact      360

cgtggtggaa tcatctgggg cccaggcacc ctggtcaccg tctcctcggg gcaacctaag      420

gctccatcag tcttcccact ggccccctgc tgcggggaca cacccagctc cacggtgacc      480

ctgggctgcc tggtcaaagg gtacctcccg gagccagtga ccgtgacctg gaactcgggc      540

accctcacca atggggtacg caccttcccg tccgtccggc agtcctcagg cctctactcg      600

ctgagcagcg tggtgagcgt gacctcaagc agccagcccg tcacctgcaa cgtggcccac      660

ccagccacca acaccaaagt ggacaagacc gttgcgccct cgacatgcag caagcccacg      720

tgcccacccc ctgaactcct ggggggaccg tctgtcttca tcttcccccc aaaacccaag      780

gacaccctca tgatctcacg cacccccgag gtcacatgcg tggtggtgga cgtgagccag      840

gatgaccccg aggtgcagtt cacatggtac ataaacaacg agcaggtgcg caccgcccgg      900

ccgccgctac gggagcagca gttcaacagc acgatccgcg tggtcagcac cctccccatc      960

gcgcaccagg actggctgag gggcaaggag ttcaagtgca aagtccacaa caaggcactc     1020

ccggccccca tcgagaaaac catctccaaa gccagagggc agcccctgga gccgaaggtc     1080

tacaccatgg gccctccccg ggaggagctg agcagcaggt cggtcagcct gacctgcatg     1140

atcaacggct tctacccttc cgacatctcg gtggagtggg agaagaacgg gaaggcagag     1200

gacaactaca agaccacgcc ggccgtgctg gacagcgacg gctcctactt cctctacagc     1260

aagctctcag tgcccacgag tgagtggcag cggggcgacg tcttcacctg ctccgtgatg     1320

cacgaggcct tgcacaacca ctacacgcag aagtccatct cccgctctcc gggtaaatga     1380


<210>  8
<211>  717
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  8
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgcca tcgtggtgac ccagactcca tcttccaagt ctgtccctgt gggaggcaca      120

gtcaccatca gttgccagtc cagtcagagt gtttatagta acaatcgctt agcctggtat      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatt atgcatccat tctggcatct      240

ggggtctcat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gatgtggtgt gtgacgatgc tgccacttac tactgtgcag gatataaata tcgtgacagt      360

gataatactg ctttcggcgg agggaccgag gtggtggtca aaggtgatcc agttgcacct      420

actgtcctca tcttcccacc agctgctgat caggtggcaa ctggaacagt caccatcgtg      480

tgtgtggcga ataaatactt tcccgatgtc accgtcacct gggaggtgga tggcaccacc      540

caaacaactg gcatcgagaa cagtaaaaca ccgcagaatt ctgcagattg tacctacaac      600

ctcagcagca ctctgacact gaccagcaca cagtacaaca gccacaaaga gtacacctgc      660

aaggtgaccc agggcacgac ctcagtcgtc cagagcttca ataggggtga ctgttag         717


<210>  9
<211>  136
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  9

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ser Ile Asn Asn Leu Gly Ser Ala Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Gly Ser Gly Gly Thr Ser Asn Ser Tyr Asn Ile Trp Gly Pro 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser 
    130                 135     


<210>  10
<211>  134
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  10

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ile Val Met Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Thr Ile Tyr Asn Asn Asn Gln Leu Ser Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Thr Leu Asp Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Ala Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Val Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Tyr Lys Ser Ser Ser Thr Asp Gly Ser Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys 
    130                 


<210>  11
<211>  459
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  11

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser 
        35                  40                  45              


Arg Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ser Ile Asn Asn Leu Gly Ser Ala Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Ile Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Gly Ser Gly Gly Thr Ser Asn Ser Tyr Asn Ile Trp Gly Pro 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val 
            180                 185                 190         


Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr 
        195                 200                 205             


Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr 
225                 230                 235                 240 


Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr 
        275                 280                 285             


Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg 
    290                 295                 300                 


Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile 
305                 310                 315                 320 


Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg 
            340                 345                 350         


Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu 
        355                 360                 365             


Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu 
385                 390                 395                 400 


Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly 
            420                 425                 430         


Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 


<210>  12
<211>  238
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Ile Val Met Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Asn Cys Gln Ala Ser 
        35                  40                  45              


Gln Thr Ile Tyr Asn Asn Asn Gln Leu Ser Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Thr Leu Asp Ser 
65                  70                  75                  80  


Gly Val Ser Ser Arg Phe Lys Gly Ser Gly Ser Gly Ala Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Val Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Tyr Lys Ser Ser Ser Thr Asp Gly Ser Ala Phe Gly Gly Gly 
        115                 120                 125             


Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile 
    130                 135                 140                 


Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val 
145                 150                 155                 160 


Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val 
                165                 170                 175     


Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln 
            180                 185                 190         


Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln 
    210                 215                 220                 


Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235             


<210>  13
<211>  408
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  13
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tccgtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

accgtctctg gattctccct cagtcgcaat gcaatgagct gggtccgcca ggctccaggg      180

gaggggctgg aatggatcgg aagtattaat aatcttggta gcgcatacta cgcgagctgg      240

gcaaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa tcgaggacac ggccacctat ttctgtgcca gaggtagtgg tggtactagc      360

aattcatata acatctgggg cccaggcacc ctggtcaccg tctcctcg                   408


<210>  14
<211>  402
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  14
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgcca tcgtgatgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccaggc cagtcaaact atttataata acaaccagtt atcgtggttt      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatc tggcatccac tctggattct      240

ggggtctcat cgcggttcaa aggcagtgga tctggggcac agttcactct caccatcagc      300

gatgtggtgt gtgacgatgc tgccacttac tactgtgcag gatataagtc tagtagcact      360

gatggtagtg ctttcggcgg agggaccgag gtggtggtca aa                         402


<210>  15
<211>  1380
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  15
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tccgtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

accgtctctg gattctccct cagtcgcaat gcaatgagct gggtccgcca ggctccaggg      180

gaggggctgg aatggatcgg aagtattaat aatcttggta gcgcatacta cgcgagctgg      240

gcaaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa tcgaggacac ggccacctat ttctgtgcca gaggtagtgg tggtactagc      360

aattcatata acatctgggg cccaggcacc ctggtcaccg tctcctcggg gcaacctaag      420

gctccatcag tcttcccact ggccccctgc tgcggggaca cacccagctc cacggtgacc      480

ctgggctgcc tggtcaaagg gtacctcccg gagccagtga ccgtgacctg gaactcgggc      540

accctcacca atggggtacg caccttcccg tccgtccggc agtcctcagg cctctactcg      600

ctgagcagcg tggtgagcgt gacctcaagc agccagcccg tcacctgcaa cgtggcccac      660

ccagccacca acaccaaagt ggacaagacc gttgcgccct cgacatgcag caagcccacg      720

tgcccacccc ctgaactcct ggggggaccg tctgtcttca tcttcccccc aaaacccaag      780

gacaccctca tgatctcacg cacccccgag gtcacatgcg tggtggtgga cgtgagccag      840

gatgaccccg aggtgcagtt cacatggtac ataaacaacg agcaggtgcg caccgcccgg      900

ccgccgctac gggagcagca gttcaacagc acgatccgcg tggtcagcac cctccccatc      960

gcgcaccagg actggctgag gggcaaggag ttcaagtgca aagtccacaa caaggcactc     1020

ccggccccca tcgagaaaac catctccaaa gccagagggc agcccctgga gccgaaggtc     1080

tacaccatgg gccctccccg ggaggagctg agcagcaggt cggtcagcct gacctgcatg     1140

atcaacggct tctacccttc cgacatctcg gtggagtggg agaagaacgg gaaggcagag     1200

gacaactaca agaccacgcc ggccgtgctg gacagcgacg gctcctactt cctctacagc     1260

aagctctcag tgcccacgag tgagtggcag cggggcgacg tcttcacctg ctccgtgatg     1320

cacgaggcct tgcacaacca ctacacgcag aagtccatct cccgctctcc gggtaaatga     1380


<210>  16
<211>  717
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  16
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgcca tcgtgatgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca attgccaggc cagtcaaact atttataata acaaccagtt atcgtggttt      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatc tggcatccac tctggattct      240

ggggtctcat cgcggttcaa aggcagtgga tctggggcac agttcactct caccatcagc      300

gatgtggtgt gtgacgatgc tgccacttac tactgtgcag gatataagtc tagtagcact      360

gatggtagtg ctttcggcgg agggaccgag gtggtggtca aaggtgatcc agttgcacct      420

actgtcctca tcttcccacc agctgctgat caggtggcaa ctggaacagt caccatcgtg      480

tgtgtggcga ataaatactt tcccgatgtc accgtcacct gggaggtgga tggcaccacc      540

caaacaactg gcatcgagaa cagtaaaaca ccgcagaatt ctgcagattg tacctacaac      600

ctcagcagca ctctgacact gaccagcaca cagtacaaca gccacaaaga gtacacctgc      660

aaggtgaccc agggcacgac ctcagtcgtc cagagcttca ataggggtga ctgttag         717


<210>  17
<211>  134
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  17

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Leu Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Val Thr Cys Thr Ala Ser Gly Phe Asp Leu Ser 
        35                  40                  45              


Arg Tyr Glu Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Arg Thr Ser Gly Asn Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Ala Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Val Arg Gly Gly Pro Gly Ser Gly Ala Ala Asn Trp Gly Pro Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  18
<211>  132
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  18

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asn Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Pro Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Ala Tyr Ser Val Asn Ile Asp Ala Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Arg 
    130         


<210>  19
<211>  457
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  19

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Leu Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Val Thr Cys Thr Ala Ser Gly Phe Asp Leu Ser 
        35                  40                  45              


Arg Tyr Glu Met Ser Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Arg Thr Ser Gly Asn Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Ala Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Val Arg Gly Gly Pro Gly Ser Gly Ala Ala Asn Trp Gly Pro Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser 
        195                 200                 205             


Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro 
225                 230                 235                 240 


Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr 
        275                 280                 285             


Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln 
    290                 295                 300                 


Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His 
305                 310                 315                 320 


Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln 
            340                 345                 350         


Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu 
        355                 360                 365             


Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val 
            420                 425                 430         


Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455         


<210>  20
<211>  236
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  20

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Pro Ser Ser 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Ser Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Val Tyr Asn Asn Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Thr Ser Thr Leu Pro Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Leu Glu Cys Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Ala Gly Ala Tyr Ser Val Asn Ile Asp Ala Phe Gly Gly Gly Thr Glu 
        115                 120                 125             


Val Val Val Arg Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro 
    130                 135                 140                 


Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val 
145                 150                 155                 160 


Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly 
                165                 170                 175     


Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser 
            180                 185                 190         


Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr 
        195                 200                 205             


Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr 
    210                 215                 220                 


Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235     


<210>  21
<211>  402
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  21
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtctg       60

tcggtggagg agtccggggg aggcctggtc cagcctgggg gatccctgaa agtcacctgc      120

acagcctctg gattcgacct cagtagatat gaaatgagct gggtccgcca ggctccaggg      180

gaggggctgg aatggatcgg aatcattcgt actagtggta acacatatta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggcggatct gaaaatgacc      300

agtctgacaa ccgaggacac ggccacctat ttctgtgtca gaggtggtcc tggtagtggt      360

gctgctaatt ggggcccagg caccctggtc accgtctcct ca                         402


<210>  22
<211>  396
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  22
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca gttgccagtc cagtcagagt gtttataata acaactactt atcctggtat      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatt atacatccac tctgccatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gacctggagt gtgacgatgc tgccacttac tactgtgcag gcgcttatag cgttaatatt      360

gatgctttcg gcggagggac cgaggtggtg gtcaga                                396


<210>  23
<211>  1374
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  23
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtctg       60

tcggtggagg agtccggggg aggcctggtc cagcctgggg gatccctgaa agtcacctgc      120

acagcctctg gattcgacct cagtagatat gaaatgagct gggtccgcca ggctccaggg      180

gaggggctgg aatggatcgg aatcattcgt actagtggta acacatatta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggcggatct gaaaatgacc      300

agtctgacaa ccgaggacac ggccacctat ttctgtgtca gaggtggtcc tggtagtggt      360

gctgctaatt ggggcccagg caccctggtc accgtctcct cagggcaacc taaggctcca      420

tcagtcttcc cactggcccc ctgctgcggg gacacaccca gctccacggt gaccctgggc      480

tgcctggtca aagggtacct cccggagcca gtgaccgtga cctggaactc gggcaccctc      540

accaatgggg tacgcacctt cccgtccgtc cggcagtcct caggcctcta ctcgctgagc      600

agcgtggtga gcgtgacctc aagcagccag cccgtcacct gcaacgtggc ccacccagcc      660

accaacacca aagtggacaa gaccgttgcg ccctcgacat gcagcaagcc cacgtgccca      720

ccccctgaac tcctgggggg accgtctgtc ttcatcttcc ccccaaaacc caaggacacc      780

ctcatgatct cacgcacccc cgaggtcaca tgcgtggtgg tggacgtgag ccaggatgac      840

cccgaggtgc agttcacatg gtacataaac aacgagcagg tgcgcaccgc ccggccgccg      900

ctacgggagc agcagttcaa cagcacgatc cgcgtggtca gcaccctccc catcgcgcac      960

caggactggc tgaggggcaa ggagttcaag tgcaaagtcc acaacaaggc actcccggcc     1020

cccatcgaga aaaccatctc caaagccaga gggcagcccc tggagccgaa ggtctacacc     1080

atgggccctc cccgggagga gctgagcagc aggtcggtca gcctgacctg catgatcaac     1140

ggcttctacc cttccgacat ctcggtggag tgggagaaga acgggaaggc agaggacaac     1200

tacaagacca cgccggccgt gctggacagc gacggctcct acttcctcta cagcaagctc     1260

tcagtgccca cgagtgagtg gcagcggggc gacgtcttca cctgctccgt gatgcacgag     1320

gccttgcaca accactacac gcagaagtcc atctcccgct ctccgggtaa atga           1374


<210>  24
<211>  711
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  24
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactcca tcctccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca gttgccagtc cagtcagagt gtttataata acaactactt atcctggtat      180

cagcagaaac cagggcagcc tcccaagctc ctgatctatt atacatccac tctgccatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gacctggagt gtgacgatgc tgccacttac tactgtgcag gcgcttatag cgttaatatt      360

gatgctttcg gcggagggac cgaggtggtg gtcagaggtg atccagttgc acctactgtc      420

ctcatcttcc caccagctgc tgatcaggtg gcaactggaa cagtcaccat cgtgtgtgtg      480

gcgaataaat actttcccga tgtcaccgtc acctgggagg tggatggcac cacccaaaca      540

actggcatcg agaacagtaa aacaccgcag aattctgcag attgtaccta caacctcagc      600

agcactctga cactgaccag cacacagtac aacagccaca aagagtacac ctgcaaggtg      660

acccagggca cgacctcagt cgtccagagc ttcaataggg gtgactgtta g               711


<210>  25
<211>  139
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  25

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Ala Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Ala Val Ser Gly Ile Ser Leu Ser 
        35                  40                  45              


Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Val Ile Tyr Ala Ser Gly Gly Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Leu Ser Tyr Tyr Thr Tyr Gly His Ala Tyr Leu Lys Asp Ile 
        115                 120                 125             


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 


<210>  26
<211>  135
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  26

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Leu Tyr Asn His Asn Ser Leu Ala Trp Phe Gln Gln Lys Ala 
    50                  55                  60                  


Gly Gln Pro Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Ser Tyr Asp Cys Ser Ser Ala Asp Cys Thr Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys 
    130                 135 


<210>  27
<211>  462
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  27

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Ala Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Ala Val Ser Gly Ile Ser Leu Ser 
        35                  40                  45              


Ser Tyr Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Val Ile Tyr Ala Ser Gly Gly Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp 
                85                  90                  95      


Leu Lys Met Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys 
            100                 105                 110         


Ala Arg Leu Ser Tyr Tyr Thr Tyr Gly His Ala Tyr Leu Lys Asp Ile 
        115                 120                 125             


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser 
145                 150                 155                 160 


Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val 
                165                 170                 175     


Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe 
            180                 185                 190         


Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser 
225                 230                 235                 240 


Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp Pro Glu Val 
        275                 280                 285             


Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro 
    290                 295                 300                 


Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr 
305                 310                 315                 320 


Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys 
                325                 330                 335     


Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         


Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro 
        355                 360                 365             


Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile 
    370                 375                 380                 


Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly 
385                 390                 395                 400 


Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp 
                405                 410                 415     


Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp 
            420                 425                 430         


Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             


Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455                 460         


<210>  28
<211>  239
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  28

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Thr Phe Ala Gln Val Leu Thr Gln Thr Ala Ser Pro 
            20                  25                  30          


Val Ser Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ser Ser 
        35                  40                  45              


Gln Ser Leu Tyr Asn His Asn Ser Leu Ala Trp Phe Gln Gln Lys Ala 
    50                  55                  60                  


Gly Gln Pro Pro Lys Arg Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Asp Val Gln Cys Ala Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gly Ser Tyr Asp Cys Ser Ser Ala Asp Cys Thr Ala Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  29
<211>  417
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  29
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggcggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

gcggtctctg gaatatccct cagtagctat gcaatgaact gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg agtcatttat gctagtggtg gcacatacta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa ccgaggacac ggccacctat ttctgtgcaa gattgagtta ctatacttat      360

ggccatgctt atcttaagga catctggggc ccaggcaccc tggtcaccgt ctcctca         417


<210>  30
<211>  405
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  30
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactgca tcgcccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca agtgccagtc cagtcagagt ctttataatc acaactcctt agcctggttt      180

cagcagaaag cagggcagcc tcccaagcgc ctgatctatt ctgcatccac tctggcatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gacgtgcagt gtgccgatgc tgccacttac tactgtcaag gcagttatga ttgtagtagt      360

gctgattgta ctgctttcgg cggagggacc gaggtggtgg tcaaa                      405


<210>  31
<211>  1389
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  31
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggcggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

gcggtctctg gaatatccct cagtagctat gcaatgaact gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg agtcatttat gctagtggtg gcacatacta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgtcgacca cggtggatct gaaaatgacc      300

agtctgacaa ccgaggacac ggccacctat ttctgtgcaa gattgagtta ctatacttat      360

ggccatgctt atcttaagga catctggggc ccaggcaccc tggtcaccgt ctcctcaggg      420

caacctaagg ctccatcagt cttcccactg gccccctgct gcggggacac acccagctcc      480

acggtgaccc tgggctgcct ggtcaaaggg tacctcccgg agccagtgac cgtgacctgg      540

aactcgggca ccctcaccaa tggggtacgc accttcccgt ccgtccggca gtcctcaggc      600

ctctactcgc tgagcagcgt ggtgagcgtg acctcaagca gccagcccgt cacctgcaac      660

gtggcccacc cagccaccaa caccaaagtg gacaagaccg ttgcgccctc gacatgcagc      720

aagcccacgt gcccaccccc tgaactcctg gggggaccgt ctgtcttcat cttcccccca      780

aaacccaagg acaccctcat gatctcacgc acccccgagg tcacatgcgt ggtggtggac      840

gtgagccagg atgaccccga ggtgcagttc acatggtaca taaacaacga gcaggtgcgc      900

accgcccggc cgccgctacg ggagcagcag ttcaacagca cgatccgcgt ggtcagcacc      960

ctccccatcg cgcaccagga ctggctgagg ggcaaggagt tcaagtgcaa agtccacaac     1020

aaggcactcc cggcccccat cgagaaaacc atctccaaag ccagagggca gcccctggag     1080

ccgaaggtct acaccatggg ccctccccgg gaggagctga gcagcaggtc ggtcagcctg     1140

acctgcatga tcaacggctt ctacccttcc gacatctcgg tggagtggga gaagaacggg     1200

aaggcagagg acaactacaa gaccacgccg gccgtgctgg acagcgacgg ctcctacttc     1260

ctctacagca agctctcagt gcccacgagt gagtggcagc ggggcgacgt cttcacctgc     1320

tccgtgatgc acgaggcctt gcacaaccac tacacgcaga agtccatctc ccgctctccg     1380

ggtaaatga                                                             1389


<210>  32
<211>  720
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  32
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

acatttgccc aagtgctgac ccagactgca tcgcccgtgt ctgcagctgt gggaggcaca      120

gtcaccatca agtgccagtc cagtcagagt ctttataatc acaactcctt agcctggttt      180

cagcagaaag cagggcagcc tcccaagcgc ctgatctatt ctgcatccac tctggcatct      240

ggggtcccat cgcggttcaa aggcagtgga tctgggacac agttcactct caccatcagc      300

gacgtgcagt gtgccgatgc tgccacttac tactgtcaag gcagttatga ttgtagtagt      360

gctgattgta ctgctttcgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      420

cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag      720


<210>  33
<211>  133
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  33

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Ser 
        35                  40                  45              


Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Tyr Ala Ser Gly Lys Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Val Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Asp Arg Asp Tyr Tyr Gly Met Asp Pro Trp Gly Pro Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser 
    130             


<210>  34
<211>  135
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  34

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Asp Ile Val Met Thr Gln Thr Pro Ala 
            20                  25                  30          


Ser Val Glu Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
        35                  40                  45              


Ser Gln Ser Ile Ser Asp Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Arg Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr Glu Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Asp Leu Glu Cys Ala Ala Ala Ala Ile Tyr Tyr Cys Gln 
            100                 105                 110         


Thr Thr Tyr Gly Ser Ser Gly Ala Gly Tyr Tyr Asn Val Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys 
    130                 135 


<210>  35
<211>  456
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  35

Met Glu Thr Gly Leu Arg Trp Leu Leu Leu Val Ala Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro 
            20                  25                  30          


Gly Thr Pro Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser Leu Ser 
        35                  40                  45              


Ser Tyr Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Ile Ile Tyr Ala Ser Gly Lys Thr Tyr Tyr Ala Ser Trp 
65                  70                  75                  80  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu 
                85                  90                  95      


Lys Val Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
            100                 105                 110         


Arg Asp Arg Asp Tyr Tyr Gly Met Asp Pro Trp Gly Pro Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
                165                 170                 175     


Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser 
        195                 200                 205             


Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser Gln Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile 
        275                 280                 285             


Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln 
    290                 295                 300                 


Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala His Gln 
305                 310                 315                 320 


Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro 
            340                 345                 350         


Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser 
        355                 360                 365             


Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe 
            420                 425                 430         


Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Ile Ser Arg Ser Pro Gly Lys 
    450                 455     


<210>  36
<211>  239
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  36

Met Asp Thr Arg Ala Pro Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Ala Asp Ile Val Met Thr Gln Thr Pro Ala 
            20                  25                  30          


Ser Val Glu Ala Ala Val Gly Gly Thr Val Thr Ile Lys Cys Gln Ala 
        35                  40                  45              


Ser Gln Ser Ile Ser Asp Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Gln Arg Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr Glu Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Asp Leu Glu Cys Ala Ala Ala Ala Ile Tyr Tyr Cys Gln 
            100                 105                 110         


Thr Thr Tyr Gly Ser Ser Gly Ala Gly Tyr Tyr Asn Val Phe Gly Gly 
        115                 120                 125             


Gly Thr Glu Val Val Val Lys Gly Asp Pro Val Ala Pro Thr Val Leu 
    130                 135                 140                 


Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly Thr Val Thr Ile 
145                 150                 155                 160 


Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr Val Thr Trp Glu 
                165                 170                 175     


Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro 
            180                 185                 190         


Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr Cys Lys Val Thr 
    210                 215                 220                 


Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg Gly Asp Cys 
225                 230                 235                 


<210>  37
<211>  399
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  37
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gattgtccct cagtagctat gcagtgagct gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg aatcatttat gctagtggta aaacatacta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa ggtgaccagt      300

ctgacaaccg aggacacggc cacctatttc tgtgccagag accgagatta ttacggcatg      360

gacccctggg gcccagggac cctcgtcacc gtctcttca                             399


<210>  38
<211>  405
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  38
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgctg acattgtgat gacccagact ccagcctccg tggaggcagc tgtgggaggc      120

acagtcacca tcaagtgcca ggccagtcag agcattagtg actacttatc ctggtatcag      180

cagaaaccag ggcagcgtcc caagctcctg atctatgaag catccaagct ggcctctggg      240

gtcccgtcgc ggttcagcgg cagtggatat gggacagagt tcactctcac catcagcgac      300

ctggagtgtg ccgctgctgc catttactac tgtcaaacca cttatggtag tagtggtgct      360

ggttattata atgtttttgg cggagggacc gaggtggtgg tcaaa                      405


<210>  39
<211>  1371
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  39
atggagactg ggctgcgctg gcttctcctg gtcgctgtgc tcaaaggtgt ccagtgtcag       60

tcggtggagg agtccggggg tcgcctggtc acgcctggga cacccctgac actcacctgc      120

acagtctctg gattgtccct cagtagctat gcagtgagct gggtccgcca ggctccaggg      180

aaggggctgg aatggatcgg aatcatttat gctagtggta aaacatacta cgcgagctgg      240

gcgaaaggcc gattcaccat ctccaaaacc tcgaccacgg tggatctgaa ggtgaccagt      300

ctgacaaccg aggacacggc cacctatttc tgtgccagag accgagatta ttacggcatg      360

gacccctggg gcccagggac cctcgtcacc gtctcttcag ggcaacctaa ggctccatca      420

gtcttcccac tggccccctg ctgcggggac acacccagct ccacggtgac cctgggctgc      480

ctggtcaaag ggtacctccc ggagccagtg accgtgacct ggaactcggg caccctcacc      540

aatggggtac gcaccttccc gtccgtccgg cagtcctcag gcctctactc gctgagcagc      600

gtggtgagcg tgacctcaag cagccagccc gtcacctgca acgtggccca cccagccacc      660

aacaccaaag tggacaagac cgttgcgccc tcgacatgca gcaagcccac gtgcccaccc      720

cctgaactcc tggggggacc gtctgtcttc atcttccccc caaaacccaa ggacaccctc      780

atgatctcac gcacccccga ggtcacatgc gtggtggtgg acgtgagcca ggatgacccc      840

gaggtgcagt tcacatggta cataaacaac gagcaggtgc gcaccgcccg gccgccgcta      900

cgggagcagc agttcaacag cacgatccgc gtggtcagca ccctccccat cgcgcaccag      960

gactggctga ggggcaagga gttcaagtgc aaagtccaca acaaggcact cccggccccc     1020

atcgagaaaa ccatctccaa agccagaggg cagcccctgg agccgaaggt ctacaccatg     1080

ggccctcccc gggaggagct gagcagcagg tcggtcagcc tgacctgcat gatcaacggc     1140

ttctaccctt ccgacatctc ggtggagtgg gagaagaacg ggaaggcaga ggacaactac     1200

aagaccacgc cggccgtgct ggacagcgac ggctcctact tcctctacag caagctctca     1260

gtgcccacga gtgagtggca gcggggcgac gtcttcacct gctccgtgat gcacgaggcc     1320

ttgcacaacc actacacgca gaagtccatc tcccgctctc cgggtaaatg a              1371


<210>  40
<211>  720
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  40
atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct cccaggtgcc       60

agatgtgctg acattgtgat gacccagact ccagcctccg tggaggcagc tgtgggaggc      120

acagtcacca tcaagtgcca ggccagtcag agcattagtg actacttatc ctggtatcag      180

cagaaaccag ggcagcgtcc caagctcctg atctatgaag catccaagct ggcctctggg      240

gtcccgtcgc ggttcagcgg cagtggatat gggacagagt tcactctcac catcagcgac      300

ctggagtgtg ccgctgctgc catttactac tgtcaaacca cttatggtag tagtggtgct      360

ggttattata atgtttttgg cggagggacc gaggtggtgg tcaaaggtga tccagttgca      420

cctactgtcc tcatcttccc accagctgct gatcaggtgg caactggaac agtcaccatc      480

gtgtgtgtgg cgaataaata ctttcccgat gtcaccgtca cctgggaggt ggatggcacc      540

acccaaacaa ctggcatcga gaacagtaaa acaccgcaga attctgcaga ttgtacctac      600

aacctcagca gcactctgac actgaccagc acacagtaca acagccacaa agagtacacc      660

tgcaaggtga cccagggcac gacctcagtc gtccagagct tcaatagggg tgactgttag      720


<210>  41
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  42
<211>  477
<212>  PRT
<213>  Macaca mulatta

<400>  42

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Gly Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Ser Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  43
<211>  477
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Met Ser Thr Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Asp Asp 
        35                  40                  45              


Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Ser Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Ala Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Glu Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ala Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Thr Cys Gln Phe Asp Lys Thr Val Ala Val Val Ala 
                325                 330                 335     


Lys Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Thr Phe Tyr Asp Ala Ser Asn Thr 
            420                 425                 430         


Asp Ala Leu Thr Pro Leu Phe Ser Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Met Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Ser Glu Gln Ala 
465                 470                 475         


<210>  44
<211>  477
<212>  PRT
<213>  Mus musculus 

<400>  44

Met Ser Ala Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ser Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala Gln Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Met Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Thr Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Asp Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Thr Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asn Pro 
            420                 425                 430         


Asp Val Leu Thr Pro Ile Phe Ser Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Ile Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gln Glu Gln Ala 
465                 470                 475         


<210>  45
<211>  478
<212>  PRT
<213>  Sus scrofa

<400>  45

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Ser Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Val Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Gly Val Leu Glu Gln Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Leu Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Lys Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Met 
        275                 280                 285             


Gln Glu Leu Thr Phe Asp Pro Ser Thr Ala His Pro Ser Leu Val Leu 
    290                 295                 300                 


Ser Ala Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Thr 
                325                 330                 335     


His Gln Leu Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Gly Ala Gln Ala Gly Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Ser Arg Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Ser Gly Gly Glu Ala 
465                 470                 475             


<210>  46
<211>  477
<212>  PRT
<213>  Canis familaris

<400>  46

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Pro Cys Pro Cys Cys Gln Ala Leu Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Leu Leu Glu His Gln Leu Met Glu 
145                 150                 155                 160 


Val Glu Glu Met Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Val Thr 
        275                 280                 285             


Lys Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Leu 
    290                 295                 300                 


Ser Pro Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Cys Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Val Leu Ser Asp Gly Glu His Tyr Trp Glu Val Gln Val Gly 
            340                 345                 350         


Glu Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Gln Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Pro 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Glu Glu Ala 
465                 470                 475         


<210>  47
<211>  477
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  47

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Asn Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Val Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ser Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Ser 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Thr Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Ser Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Gly Leu His Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Pro Thr Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Asp Asp Ala Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Leu Leu Ser Asp Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ser Glu Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Thr Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Leu Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe Arg Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Gln Glu Ala 
465                 470                 475         


<210>  48
<211>  477
<212>  PRT
<213>  Artificial Sequence

<400>  48

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  49
<211>  477
<212>  PRT
<213>  Artificial Sequence

<400>  49

Met Ser Ala Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ser Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala Gln Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Met Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Thr Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Asp Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Thr Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asn Pro 
            420                 425                 430         


Asp Val Leu Thr Pro Ile Phe Ser Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Ile Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gln Glu Gln Ala 
465                 470                 475         


<210>  50
<211>  477
<212>  PRT
<213>  Artificial Sequence

<400>  50

Met Ser Thr Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Asp Asp 
        35                  40                  45              


Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Ser Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Ala Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Glu Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ala Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Thr Cys Gln Phe Asp Lys Thr Val Ala Val Val Ala 
                325                 330                 335     


Lys Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Thr Phe Tyr Asp Ala Ser Asn Thr 
            420                 425                 430         


Asp Ala Leu Thr Pro Leu Phe Ser Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Met Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Ser Glu Gln Ala 
465                 470                 475         


<210>  51
<211>  477
<212>  PRT
<213>  Artificial Sequence

<400>  51

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Gly Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Ser Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  52
<211>  478
<212>  PRT
<213>  Artificial Sequence

<400>  52

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Ser Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Val Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Gly Val Leu Glu Gln Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Leu Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Lys Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Met 
        275                 280                 285             


Gln Glu Leu Thr Phe Asp Pro Ser Thr Ala His Pro Ser Leu Val Leu 
    290                 295                 300                 


Ser Ala Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Thr 
                325                 330                 335     


His Gln Leu Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Gly Ala Gln Ala Gly Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Ser Arg Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Ala Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Ser Gly Gly Glu Ala 
465                 470                 475             


<210>  53
<211>  477
<212>  PRT
<213>  Artificial Sequence

<400>  53

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Pro Cys Pro Cys Cys Gln Ala Leu Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Leu Leu Glu His Gln Leu Met Glu 
145                 150                 155                 160 


Val Glu Glu Met Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Val Thr 
        275                 280                 285             


Lys Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Leu 
    290                 295                 300                 


Ser Pro Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Cys Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


Gln Gln Val Leu Ser Asp Gly Glu His Tyr Trp Glu Val Gln Val Gly 
            340                 345                 350         


Glu Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Gln Ala Ser Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Ile Gly Ile Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Pro 
            420                 425                 430         


Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Glu Glu Ala 
465                 470                 475         


<210>  54
<211>  477
<212>  PRT
<213>  Artificial Sequence

<400>  54

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Cys 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
            260                 265                 270         


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
        275                 280                 285             


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
    290                 295                 300                 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
305                 310                 315                 320 


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
                325                 330                 335     


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
            340                 345                 350         


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
        355                 360                 365             


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
    370                 375                 380                 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
385                 390                 395                 400 


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
                405                 410                 415     


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
            420                 425                 430         


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
        435                 440                 445             


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
    450                 455                 460                 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
465                 470                 475         


<210>  55
<211>  333
<212>  PRT
<213>  Artificial Sequence

<400>  55

Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
1               5                   10                  15      


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
            20                  25                  30          


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
        35                  40                  45              


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
    50                  55                  60                  


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
65                  70                  75                  80  


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
                85                  90                  95      


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
            100                 105                 110         


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
        115                 120                 125             


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
    130                 135                 140                 


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
145                 150                 155                 160 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 
                165                 170                 175     


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
            180                 185                 190         


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
        195                 200                 205             


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
    210                 215                 220                 


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
225                 230                 235                 240 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
                245                 250                 255     


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
            260                 265                 270         


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
        275                 280                 285             


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
    290                 295                 300                 


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
305                 310                 315                 320 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
                325                 330             


<210>  56
<211>  333
<212>  PRT
<213>  Artificial Sequence

<400>  56

Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
1               5                   10                  15      


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
            20                  25                  30          


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
        35                  40                  45              


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
    50                  55                  60                  


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
65                  70                  75                  80  


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
                85                  90                  95      


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
            100                 105                 110         


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 
        115                 120                 125             


Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 
    130                 135                 140                 


Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 
145                 150                 155                 160 


Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Gly Gln Lys Ala Pro Pro 
                165                 170                 175     


Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 
            180                 185                 190         


His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 
        195                 200                 205             


Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 
    210                 215                 220                 


Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 
225                 230                 235                 240 


Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 
                245                 250                 255     


Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 
            260                 265                 270         


Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 
        275                 280                 285             


Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 
    290                 295                 300                 


Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 
305                 310                 315                 320 


Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 
                325                 330             


<210>  57
<211>  269
<212>  PRT
<213>  Artificial Sequence

<400>  57

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 
        35                  40                  45              


Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 
    50                  55                  60                  


Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 
65                  70                  75                  80  


Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 
                85                  90                  95      


Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 
            100                 105                 110         


Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 
        115                 120                 125             


Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 
    130                 135                 140                 


Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 
145                 150                 155                 160 


Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 
                165                 170                 175     


Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 
            180                 185                 190         


Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 
        195                 200                 205             


Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 
    210                 215                 220                 


Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 
225                 230                 235                 240 


Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ala Pro 
                245                 250                 255     


Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser 
            260                 265                 


<210>  58
<211>  1382
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gly Thr Gly Gly Arg Arg Gly Ala Ala Ala Ala Pro Leu Leu Val 
1               5                   10                  15      


Ala Val Ala Ala Leu Leu Leu Gly Ala Ala Gly His Leu Tyr Pro Gly 
            20                  25                  30          


Glu Val Cys Pro Gly Met Asp Ile Arg Asn Asn Leu Thr Arg Leu His 
        35                  40                  45              


Glu Leu Glu Asn Cys Ser Val Ile Glu Gly His Leu Gln Ile Leu Leu 
    50                  55                  60                  


Met Phe Lys Thr Arg Pro Glu Asp Phe Arg Asp Leu Ser Phe Pro Lys 
65                  70                  75                  80  


Leu Ile Met Ile Thr Asp Tyr Leu Leu Leu Phe Arg Val Tyr Gly Leu 
                85                  90                  95      


Glu Ser Leu Lys Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Ser 
            100                 105                 110         


Arg Leu Phe Phe Asn Tyr Ala Leu Val Ile Phe Glu Met Val His Leu 
        115                 120                 125             


Lys Glu Leu Gly Leu Tyr Asn Leu Met Asn Ile Thr Arg Gly Ser Val 
    130                 135                 140                 


Arg Ile Glu Lys Asn Asn Glu Leu Cys Tyr Leu Ala Thr Ile Asp Trp 
145                 150                 155                 160 


Ser Arg Ile Leu Asp Ser Val Glu Asp Asn Tyr Ile Val Leu Asn Lys 
                165                 170                 175     


Asp Asp Asn Glu Glu Cys Gly Asp Ile Cys Pro Gly Thr Ala Lys Gly 
            180                 185                 190         


Lys Thr Asn Cys Pro Ala Thr Val Ile Asn Gly Gln Phe Val Glu Arg 
        195                 200                 205             


Cys Trp Thr His Ser His Cys Gln Lys Val Cys Pro Thr Ile Cys Lys 
    210                 215                 220                 


Ser His Gly Cys Thr Ala Glu Gly Leu Cys Cys His Ser Glu Cys Leu 
225                 230                 235                 240 


Gly Asn Cys Ser Gln Pro Asp Asp Pro Thr Lys Cys Val Ala Cys Arg 
                245                 250                 255     


Asn Phe Tyr Leu Asp Gly Arg Cys Val Glu Thr Cys Pro Pro Pro Tyr 
            260                 265                 270         


Tyr His Phe Gln Asp Trp Arg Cys Val Asn Phe Ser Phe Cys Gln Asp 
        275                 280                 285             


Leu His His Lys Cys Lys Asn Ser Arg Arg Gln Gly Cys His Gln Tyr 
    290                 295                 300                 


Val Ile His Asn Asn Lys Cys Ile Pro Glu Cys Pro Ser Gly Tyr Thr 
305                 310                 315                 320 


Met Asn Ser Ser Asn Leu Leu Cys Thr Pro Cys Leu Gly Pro Cys Pro 
                325                 330                 335     


Lys Val Cys His Leu Leu Glu Gly Glu Lys Thr Ile Asp Ser Val Thr 
            340                 345                 350         


Ser Ala Gln Glu Leu Arg Gly Cys Thr Val Ile Asn Gly Ser Leu Ile 
        355                 360                 365             


Ile Asn Ile Arg Gly Gly Asn Asn Leu Ala Ala Glu Leu Glu Ala Asn 
    370                 375                 380                 


Leu Gly Leu Ile Glu Glu Ile Ser Gly Tyr Leu Lys Ile Arg Arg Ser 
385                 390                 395                 400 


Tyr Ala Leu Val Ser Leu Ser Phe Phe Arg Lys Leu Arg Leu Ile Arg 
                405                 410                 415     


Gly Glu Thr Leu Glu Ile Gly Asn Tyr Ser Phe Tyr Ala Leu Asp Asn 
            420                 425                 430         


Gln Asn Leu Arg Gln Leu Trp Asp Trp Ser Lys His Asn Leu Thr Ile 
        435                 440                 445             


Thr Gln Gly Lys Leu Phe Phe His Tyr Asn Pro Lys Leu Cys Leu Ser 
    450                 455                 460                 


Glu Ile His Lys Met Glu Glu Val Ser Gly Thr Lys Gly Arg Gln Glu 
465                 470                 475                 480 


Arg Asn Asp Ile Ala Leu Lys Thr Asn Gly Asp Gln Ala Ser Cys Glu 
                485                 490                 495     


Asn Glu Leu Leu Lys Phe Ser Tyr Ile Arg Thr Ser Phe Asp Lys Ile 
            500                 505                 510         


Leu Leu Arg Trp Glu Pro Tyr Trp Pro Pro Asp Phe Arg Asp Leu Leu 
        515                 520                 525             


Gly Phe Met Leu Phe Tyr Lys Glu Ala Pro Tyr Gln Asn Val Thr Glu 
    530                 535                 540                 


Phe Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Thr Val Val Asp 
545                 550                 555                 560 


Ile Asp Pro Pro Leu Arg Ser Asn Asp Pro Lys Ser Gln Asn His Pro 
                565                 570                 575     


Gly Trp Leu Met Arg Gly Leu Lys Pro Trp Thr Gln Tyr Ala Ile Phe 
            580                 585                 590         


Val Lys Thr Leu Val Thr Phe Ser Asp Glu Arg Arg Thr Tyr Gly Ala 
        595                 600                 605             


Lys Ser Asp Ile Ile Tyr Val Gln Thr Asp Ala Thr Asn Pro Ser Val 
    610                 615                 620                 


Pro Leu Asp Pro Ile Ser Val Ser Asn Ser Ser Ser Gln Ile Ile Leu 
625                 630                 635                 640 


Lys Trp Lys Pro Pro Ser Asp Pro Asn Gly Asn Ile Thr His Tyr Leu 
                645                 650                 655     


Val Phe Trp Glu Arg Gln Ala Glu Asp Ser Glu Leu Phe Glu Leu Asp 
            660                 665                 670         


Tyr Cys Leu Lys Gly Leu Lys Leu Pro Ser Arg Thr Trp Ser Pro Pro 
        675                 680                 685             


Phe Glu Ser Glu Asp Ser Gln Lys His Asn Gln Ser Glu Tyr Glu Asp 
    690                 695                 700                 


Ser Ala Gly Glu Cys Cys Ser Cys Pro Lys Thr Asp Ser Gln Ile Leu 
705                 710                 715                 720 


Lys Glu Leu Glu Glu Ser Ser Phe Arg Lys Thr Phe Glu Asp Tyr Leu 
                725                 730                 735     


His Asn Val Val Phe Val Pro Arg Lys Thr Ser Ser Gly Thr Gly Ala 
            740                 745                 750         


Glu Asp Pro Arg Pro Ser Arg Lys Arg Arg Ser Leu Gly Asp Val Gly 
        755                 760                 765             


Asn Val Thr Val Ala Val Pro Thr Val Ala Ala Phe Pro Asn Thr Ser 
    770                 775                 780                 


Ser Thr Ser Val Pro Thr Ser Pro Glu Glu His Arg Pro Phe Glu Lys 
785                 790                 795                 800 


Val Val Asn Lys Glu Ser Leu Val Ile Ser Gly Leu Arg His Phe Thr 
                805                 810                 815     


Gly Tyr Arg Ile Glu Leu Gln Ala Cys Asn Gln Asp Thr Pro Glu Glu 
            820                 825                 830         


Arg Cys Ser Val Ala Ala Tyr Val Ser Ala Arg Thr Met Pro Glu Ala 
        835                 840                 845             


Lys Ala Asp Asp Ile Val Gly Pro Val Thr His Glu Ile Phe Glu Asn 
    850                 855                 860                 


Asn Val Val His Leu Met Trp Gln Glu Pro Lys Glu Pro Asn Gly Leu 
865                 870                 875                 880 


Ile Val Leu Tyr Glu Val Ser Tyr Arg Arg Tyr Gly Asp Glu Glu Leu 
                885                 890                 895     


His Leu Cys Val Ser Arg Lys His Phe Ala Leu Glu Arg Gly Cys Arg 
            900                 905                 910         


Leu Arg Gly Leu Ser Pro Gly Asn Tyr Ser Val Arg Ile Arg Ala Thr 
        915                 920                 925             


Ser Leu Ala Gly Asn Gly Ser Trp Thr Glu Pro Thr Tyr Phe Tyr Val 
    930                 935                 940                 


Thr Asp Tyr Leu Asp Val Pro Ser Asn Ile Ala Lys Ile Ile Ile Gly 
945                 950                 955                 960 


Pro Leu Ile Phe Val Phe Leu Phe Ser Val Val Ile Gly Ser Ile Tyr 
                965                 970                 975     


Leu Phe Leu Arg Lys Arg Gln Pro Asp Gly Pro Leu Gly Pro Leu Tyr 
            980                 985                 990         


Ala Ser Ser Asn Pro Glu Tyr Leu  Ser Ala Ser Asp Val  Phe Pro Cys 
        995                 1000                 1005             


Ser Val  Tyr Val Pro Asp Glu  Trp Glu Val Ser Arg  Glu Lys Ile 
    1010                 1015                 1020             


Thr Leu  Leu Arg Glu Leu Gly  Gln Gly Ser Phe Gly  Met Val Tyr 
    1025                 1030                 1035             


Glu Gly  Asn Ala Arg Asp Ile  Ile Lys Gly Glu Ala  Glu Thr Arg 
    1040                 1045                 1050             


Val Ala  Val Lys Thr Val Asn  Glu Ser Ala Ser Leu  Arg Glu Arg 
    1055                 1060                 1065             


Ile Glu  Phe Leu Asn Glu Ala  Ser Val Met Lys Gly  Phe Thr Cys 
    1070                 1075                 1080             


His His  Val Val Arg Leu Leu  Gly Val Val Ser Lys  Gly Gln Pro 
    1085                 1090                 1095             


Thr Leu  Val Val Met Glu Leu  Met Ala His Gly Asp  Leu Lys Ser 
    1100                 1105                 1110             


Tyr Leu  Arg Ser Leu Arg Pro  Glu Ala Glu Asn Asn  Pro Gly Arg 
    1115                 1120                 1125             


Pro Pro  Pro Thr Leu Gln Glu  Met Ile Gln Met Ala  Ala Glu Ile 
    1130                 1135                 1140             


Ala Asp  Gly Met Ala Tyr Leu  Asn Ala Lys Lys Phe  Val His Arg 
    1145                 1150                 1155             


Asp Leu  Ala Ala Arg Asn Cys  Met Val Ala His Asp  Phe Thr Val 
    1160                 1165                 1170             


Lys Ile  Gly Asp Phe Gly Met  Thr Arg Asp Ile Tyr  Glu Thr Asp 
    1175                 1180                 1185             


Tyr Tyr  Arg Lys Gly Gly Lys  Gly Leu Leu Pro Val  Arg Trp Met 
    1190                 1195                 1200             


Ala Pro  Glu Ser Leu Lys Asp  Gly Val Phe Thr Thr  Ser Ser Asp 
    1205                 1210                 1215             


Met Trp  Ser Phe Gly Val Val  Leu Trp Glu Ile Thr  Ser Leu Ala 
    1220                 1225                 1230             


Glu Gln  Pro Tyr Gln Gly Leu  Ser Asn Glu Gln Val  Leu Lys Phe 
    1235                 1240                 1245             


Val Met  Asp Gly Gly Tyr Leu  Asp Gln Pro Asp Asn  Cys Pro Glu 
    1250                 1255                 1260             


Arg Val  Thr Asp Leu Met Arg  Met Cys Trp Gln Phe  Asn Pro Lys 
    1265                 1270                 1275             


Met Arg  Pro Thr Phe Leu Glu  Ile Val Asn Leu Leu  Lys Asp Asp 
    1280                 1285                 1290             


Leu His  Pro Ser Phe Pro Glu  Val Ser Phe Phe His  Ser Glu Glu 
    1295                 1300                 1305             


Asn Lys  Ala Pro Glu Ser Glu  Glu Leu Glu Met Glu  Phe Glu Asp 
    1310                 1315                 1320             


Met Glu  Asn Val Pro Leu Asp  Arg Ser Ser His Cys  Gln Arg Glu 
    1325                 1330                 1335             


Glu Ala  Gly Gly Arg Asp Gly  Gly Ser Ser Leu Gly  Phe Lys Arg 
    1340                 1345                 1350             


Ser Tyr  Glu Glu His Ile Pro  Tyr Thr His Met Asn  Gly Gly Lys 
    1355                 1360                 1365             


Lys Asn  Gly Arg Ile Leu Thr  Leu Pro Arg Ser Asn  Pro Ser 
    1370                 1375                 1380         


<210>  59
<211>  35
<212>  DNA
<213>  Artificial Sequence

<400>  59
ataggtaccg ccaccatgtc ggctgcaccc ggcct                                  35


<210>  60
<211>  30
<212>  DNA
<213>  Artificial Sequence

<400>  60
atactcgagc ggcctgttcc tgctccggcc                                        30


<210>  61
<211>  609
<212>  PRT
<213>  Callithrix jacchus


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (480)..(480)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 
1               5                   10                  15      


Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 
            20                  25                  30          


Phe Cys His Ile Cys Leu Arg Arg Met Lys Thr Glu Pro Ala Ala Asp 
        35                  40                  45              


Asp Thr Val Pro Xaa Thr Ser Cys Gln Ala Asn Lys Pro Thr Asn Leu 
    50                  55                  60                  


Lys Xaa Xaa Xaa Xaa Xaa Xaa Gly Ala Arg Trp Pro Pro Gly Ser Thr 
65                  70                  75                  80  


Ala Arg Glu His Leu Asp Pro Leu Ser Ile Tyr Cys Glu Gln Asp Arg 
                85                  90                  95      


Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly Ser His Arg Gly His 
            100                 105                 110         


Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg Ser Arg Asp Arg Glu 
        115                 120                 125             


Met Gly Gly Arg Ile Pro Gly Ala Gly Leu Met Gly Gly Ala Glu Pro 
    130                 135                 140                 


Gly Gly Ala Arg Thr Gly Gln Arg Pro Lys Trp Tyr Ser Cys Thr Arg 
145                 150                 155                 160 


Trp Ala Gly Arg Thr Gly Ser Pro Arg Gly Ala Gly Gly Gly Ala Ala 
                165                 170                 175     


Phe Gly Arg Glu Pro Gly Gly Arg Gly Gly Ala Val Leu Met Ser Ser 
            180                 185                 190         


Ala Glu Ala His Ala Pro Leu Lys Leu Arg Asn Leu Gly Arg Pro Asp 
        195                 200                 205             


Gly Leu Gln Ala Gly Leu Thr Gly Arg Glu Ala Gly Trp Pro Gly Arg 
    210                 215                 220                 


Pro Phe Ala Thr Gly Glu Gly Leu Ala Gly Gly Leu Arg Glu Asp Pro 
225                 230                 235                 240 


Arg Arg Glu Pro Glu Gly Gly Gly Arg Pro Glu Gly Ser Gly Arg Asp 
                245                 250                 255     


Pro Ile Pro Gly Ser Leu Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu 
            260                 265                 270         


Gln Glu Ala Cys Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His 
        275                 280                 285             


Gln Leu Val Glu Val Glu Glu Thr Val Arg Gln Phe Arg Ala Ala Val 
    290                 295                 300                 


Gly Asp Gln Leu Gly Lys Met Arg Leu Phe Leu Ala Ala Leu Glu Gly 
305                 310                 315                 320 


Ser Leu Asp Arg Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala 
                325                 330                 335     


Leu Arg Arg Glu Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg 
            340                 345                 350         


Gln Met Glu Lys Val Leu Glu Glu Val Thr Asp Lys Pro Gln Thr Glu 
        355                 360                 365             


Phe Leu Met Lys Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu 
    370                 375                 380                 


Ala Glu Ser Pro Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile 
385                 390                 395                 400 


Ser Asp Asp Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu 
                405                 410                 415     


Met Pro Ala Leu Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro 
            420                 425                 430         


Ser Leu Val Val Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln 
        435                 440                 445             


Lys Ala Pro Pro Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val 
    450                 455                 460                 


Ala Val Val Ala His Gln Arg Leu Ser Glu Gly Glu His Tyr Trp Xaa 
465                 470                 475                 480 


Val Glu Val Gly Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ser Ala 
                485                 490                 495     


Glu Ala Pro Arg Arg Gly Arg Leu His Pro Val Pro Ser Gln Gly Leu 
            500                 505                 510         


Trp Leu Leu Gly Leu Arg Glu Ser Lys Ile Leu Glu Ala His Val Glu 
        515                 520                 525             


Ala Lys Glu Pro Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg 
    530                 535                 540                 


Ile Gly Leu Tyr Met Ser Phe Ser Asp Gly Val Leu Ser Phe Tyr Asp 
545                 550                 555                 560 


Ala Ser Asp Ala Asp Ala Leu Val Leu Leu Phe Ala Phe His Glu Arg 
                565                 570                 575     


Leu Pro Gly Pro Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys 
            580                 585                 590         


Gly Lys Asn Ala Gln Pro Leu Leu Leu Leu Gly Pro Glu Gly Ala Glu 
        595                 600                 605             


Ala 
    


