                         SEQUENCE LISTING

<110>  QUEEN'S UNIVERSITY AT KINGSTON
       GEORGIA TECH RESEARCH CORPORATION
       EMORY UNIVERSITY
       KINGSTON HEALTH SCIENCES CENTRE
 
<120>  VON WILLEBRAND FACTOR PROTEINS FOR TREATING BLEEDING DISORDERS

<130>  2017-037-02PCT

<150>  62/580,133
<151>  2017-11-01

<160>  69    

<170>  PatentIn version 3.5

<210>  1
<211>  8439
<212>  DNA
<213>  Primate

<400>  1
atgatcccag caaggtttgc acgcgtgctg ctggccctgg ccctgaccct gccaggcacc       60

ctgtgcgcag agggaacccg gggcagaagc tccatggccc ggtgctccct gttcggctct      120

gacttcatca acacattcga cggcagcatg tactccttcg ccggctactg tagctatctg      180

ctggccggcg attgccagaa gcggagcttt tccatcattg gcgacttcca gaatggcaag      240

agagtgtctc tgagcgtgta tctgggcgag ttctttgata tccacctgtt tgtgaacggc      300

accgtgacac agggcgacca gagagtgtcc atgccttacg cctctaaggg cctgtatctg      360

gagacagagg ccggctacta taagctgtcc ggagaggcat acggattcgt ggcaaggatc      420

gatggatccg gcaattttca ggtgctgctg tctgacagat atttcaacaa gacctgtggc      480

ctgtgcggca acttcaatat ctttgccgag gacgacttca tgacacagga gggcaccctg      540

acaagcgacc catacgattt cgccaattcc tgggccctgt ctagcggaga gcagtggtgt      600

gagagggcca gccccccttc ctctagctgc aacatctcct ctggcgagat gcagaagggc      660

ctgtgggagc agtgtcagct gctgaagagc accagcgtgt tcgcaaggtg ccacccactg      720

gtggatccag agcctttcgt ggccctgtgc gagaagacac tgtgcgagtg tgcagagggc      780

ctggagtgcg tgtgccctgc ctttctggag tacgcaagga cctgcgcaca ggagggaatg      840

gtgctgtatg gctggacaga ccactctgcc tgtagccccg tgtgcccagc aggaatggag      900

tacaagcagt gcgtgagccc ttgcaccagg acatgtcaga gcctgcacat caatgaggtg      960

tgccaggagc ggtgcgtgga tggatgcagc tgtccagagg gacagctgct ggacgagggc     1020

ctgtgcgtgg agtccaccga gtgcccttgt atgcactctg gcaagcggta cccaccagga     1080

gccagcctgt ccagggattg taatacatgc atctgtcgca acagccagtg gatctgctcc     1140

aatgaggagt gcccaggaga gtgtctggtg accggccaga gccacttcaa gtcctttgac     1200

aacagatact tcaccttcag cggcatctgt cagtatctgc tggccagaga ctgccaggat     1260

cactctttca gcatcgtgat cgagacagtg cagtgtgccg acgatcctga cgccgtgtgc     1320

accaggtctg tgacagtgcg cctgccaggc ctgcacaaca gcctggtgaa gctgaagcac     1380

ggaggaggag tggcaatgga cggacaggat gtgcagctgc ctctgctgaa gggcgatctg     1440

aggatccagc acaccgtgac agcctctgtg cgcctgagct acggcgagga cctgcagatg     1500

gactgggatg gaaggggccg cctgctggtg aagctgtccc cagtgtacgc cggcaagact     1560

tgcggcctgt gcggcaacta taatggcaac cagggcgacg attttctgac accttctggc     1620

ctggccgagc caagggtgga ggatttcggc aatgcctgga agctgcacgg cgactgtcag     1680

gatctgcaga agcagcacag cgacccatgc gccctgaacc cacggatgac cagattttcc     1740

gaggaggcct gtgccgtgct gacctctccc acattcgagg catgccacag ggccgtgagc     1800

ccactgccat acctgaggaa ttgccgctat gacgtgtgct cctgttctga cggccgcgag     1860

tgcctgtgcg gcgccctggc ctcctacgct gccgcctgcg caggaagggg cgtgagaatc     1920

gcatggaggg agccaggcag atgcgagctg aactgtccta agggacaggt gtacctgcag     1980

tgcggaaccc catgtaatct gacatgccgg agcctgtcct atcccgatga ggagtgtaac     2040

gaggcctgcc tggagggctg cttttgtcct ccaggcctgt acatggatga gagaggcgac     2100

tgcgtgccta aggcccagtg cccatgttac tatgacggcg agatctttca gccagaggat     2160

atcttcagcg accaccacac catgtgctat tgtgaggatg gcttcatgca ctgcacaatg     2220

tctggagtgc caggcagcct gctgcctgac gccgtgctga gctccccact gtcccacagg     2280

tctaagcgga gcctgagctg taggccccct atggtgaagc tggtgtgccc tgcagataat     2340

ccaagggcag agggcctgga gtgtgcaaag acctgccaga actacgacct ggagtgtatg     2400

tccatgggat gcgtgtctgg atgcctgtgc ccaccaggaa tggtgaggca cgagaaccgc     2460

tgcgtggccc tggagcggtg cccatgtttt caccagggca aggagtatgc ccccggcgag     2520

acagtgaaga tcgactgtaa tacatgcgtg tgccgggata gaaagtggaa ctgcaccgat     2580

cacgtgtgcg acgccacctg cagcacaatc ggcatggccc actacctgac atttgatggc     2640

ctgaagtata tgttcccagg cgagtgtcag tacgtgctgg tgcaggacta ttgcggctcc     2700

aatcctggca ccttcaggat cctggtgggc aacgagggct gtagccaccc atccgtgaag     2760

tgcaagaagc gcgtgacaat cctggtggag ggcggcgaga tcgagctgtt tgatggcgaa     2820

gtgaatgtga agaggcccat gaaggacgag acacacttcg aggtggtgga gtctggccgc     2880

tacatcatcc tgctgctggg caaggccctg agcgtggtgt gggacaggca cctgtccatc     2940

tctgtggtgc tgaagcagac ctatcaggag caggtgtgcg gcctgtgcgg aaattttgat     3000

ggcatccaga acaatgacct gacatctagc aatctgcagg tggaggagga ccccgtggat     3060

ttcggcaaca gctggaaggt gtcctctcag tgtgccgaca ccaggaaggt gccactggat     3120

agctcccccg ccacctgcca caacaatatc atgaagcaga caatggtgga ttctagctgt     3180

cgcatcctga catccgatat ctttcaggac tgcaacaagc tggtggaccc tgagccatac     3240

ctggacgtgt gcatctatga cacctgctct tgtgagagca tcggcgattg cgcctgtttc     3300

tgcgacacaa tcgcagcata cgcacacgtg tgcgcacagc acggcaaggt ggtgacctgg     3360

agaaccgcca ccctgtgccc acagtcctgc gaggagcgga atctgagaga gaacggctac     3420

gagtgcgaat ggaggtataa ttcttgtgca ccagcatgca gggtgacctg tcagcaccca     3480

gagcctctgg cctgccctgt gcagtgcgtg gagggatgcc acgcacactg tcctccaggc     3540

aagatcctgg atgagctgct gcagacctgc gtgaaccccg aggactgccc cgtgtgcgag     3600

gtggcaggcc ggagactggc cagcggcaag aaggtgacac tgaatccctc cgatcctgag     3660

cactgccaga tctgtcactg cgacggcgtg aacctgacct gtgaggcctg ccaggagcca     3720

ggaggcctgg tggtgccacc tacagacgcc ccagtgtctc ccaccacacc ttacgtggag     3780

gacatcagcg agccacccct gcacgacttc tactgctcca ggctgctgga tctggtgttc     3840

ctgctggacg gatcctctag gctgagcgag gccgagtttg aggtgctgaa ggccttcgtg     3900

gtggacatga tggagaggct gcgcatcagc cagaagtggg tgcgggtggc agtggtggag     3960

taccacgatg gctcccacgc ctatatcggc ctgaaggaca ggaagcggcc cagcgagctg     4020

aggcgcatcg cctcccaggt gaagtacgca ggctctcagg tggccagcac ctccgaggtg     4080

ctgaagtata cactgttcca gatctttggc aagatcgacc ggccagaggc ctccagaatc     4140

gccctgctgc tgatggccag ccaggagcca cagaggatgt cccgcaactt tgtgagatac     4200

gtgcagggcc tgaagaagaa gaaagtgatc gtgatccctg tgggcatcgg cccacacgcc     4260

aatctgaagc agatcaggct gatcgagaag caggcccccg agaacaaggc cttcgtgctg     4320

tccggagtgg acgagctgga gcagcagagg gatgagatcg tgtcttatct gtgcgatctg     4380

gcaccagagg cacctccacc aaccatgcct ccacacatgg cccaggtgac agtgggacca     4440

ggcctgctgg gcgtgagccc actgggcccc aagcggaatt ccatggtgct ggacgtggcc     4500

ttcgtgctgg agggctccga taagatcggc gaggccgact tcaaccggag caaggagttc     4560

atggaggaag tgatccagag aatggatgtg ggccaggacg gcatccacgt gaccgtgctg     4620

cagtacagct atatggtcac agtggagtac cctttttccg aggcccagtc taagggcgat     4680

atcctgcaga gggtgcgcga gatcaggtac cagggcggca atcgcaccaa cacaggcctg     4740

gccctgcagt atctgtccga gcactctttc ctggtgtctc agggcgaccg ggagcaggca     4800

ccaaatctgg tgtatatggt gaccggcaac cctgccagcg acgagatcaa gagactgcca     4860

ggcgatatcc aggtggtgcc aatcggagtg ggacctcacg ccaatgtgca ggagctggag     4920

aggatcggct ggcctaacgc cccaatcctg atccaggatt ttgagacact gccaagggag     4980

gcaccagacc tggtgctgca gagatgctgt agcggcgagg gcctgcagat ccctacactg     5040

agcccagcac cagattgctc ccagccactg gacgtggtgc tgctgctgga tggcagctcc     5100

tctagccccg cctcttactt cgatgagatg aagagctttg ccaaggcctt catctccaag     5160

gccaatatcg gccctcacct gacccaggtg tctgtgctgc agtatggcag catcaccaca     5220

atcgacgtgc catggaacgt ggcccaggag aaggcccacc tgctgtctct ggtggatgtg     5280

atgcagaggg agggaggacc aagccagatc ggcgacgcac tgggatttgc cgtgcggtac     5340

ctgacctctg aggtgcacgg agccagacct ggagccagca aggccgtggt catcctggtg     5400

acagatgtga gcgtggactc cgtggatgct gccgccgacg cagcacggag caatagagtg     5460

accgtgttcc ccatcggcat cggcgacagg tatgacgcag cacagctgag gatcctggca     5520

ggacctgccg ccgattccaa tgtggtgaag ctgcagagga tcgaggacct gccaaccatg     5580

gtgacactgg gcaactcttt tctgcacaag ctgtgcagcg gcttcgtgag gatctgcatg     5640

gacgaggatg gcaacgagaa gcgccctggc gacgtgtgga ccctgccaga tcagtgtcac     5700

accgtgacat gccagcccga tggccagaca ctgctgaagt cccaccgcgt gaattgtgac     5760

aggggccctc gcccatcttg cccaaactct cagagccccg tgaaggtgga ggagacatgt     5820

ggctgccggt ggacatgtcc ttgcgtgtgc accggctcct ctacaagaca catcgtgacc     5880

tttgatggcc agaacttcaa gctgacaggc tcctgctctt acgtgctgtt ccagaataag     5940

gagcaggacc tggaagtgat cctgcacaac ggagcatgtt ccccaggagc aaggcaggga     6000

tgcatgaagt ctatcgaggt gaagcactct gccctgagcg tggagctgca cagcgacatg     6060

gaggtgaccg tgaatggccg gctggtgtcc gtgccttacg tgggaggcaa tatggaggtg     6120

aacatctatg gcgccatcat gcacgaggtg cggttcaacc acctgggcca catcttcacc     6180

tttacacccc agaacaatga gtttcagctg cagctgtccc ctaagacctt cgcctctaag     6240

acatacggcc tgtgcggcat ctgcgatgag aatggcgcca acgatttcat gctgagggac     6300

ggcaccgtga ccacagactg gaagaccctg gtgcaggagt ggacagtgca gcagcccggc     6360

cagacatgtc agcctatcct ggaggagcag tgcccagtga gcgatagctc ccactgtcag     6420

gtgctgctgt ccgccctgtt tgcagagtgt cacaaggtgc tggccccagc caccttctac     6480

gccatctgtc agcaggacag ctgccaccgc gagcaggtgt gcgaagtgat cgcctcttat     6540

gcacacctgt gcaggaccag cggcgtgtgc gtggattgga ggacaccaga cttctgcgcc     6600

atgagctgtc ccccttccct ggtgtacaat cactgcgaga ggggatgtcc aagacactgc     6660

gacggcaacg tgtctagctg tggcgatcac ccttctgagg gctgcttttg tccacccaat     6720

caggtcatgc tggagggaag ctgcgtgcct gaggaggcat gtacccagtg catcggagag     6780

gatggcgtgc ggcaccagtt cctggaggca tgggtgcctg accaccagcc atgccagatc     6840

tgcacatgtc tgagcggcag aaaagtgaat tgtaccacac agccatgccc taccgcaaag     6900

gcacctacat gtggcctgtg cgaggtggca aggctgagac agaacgcaga ccagtgctgt     6960

ccagagtacg agtgcgtgtg cgatcccgtg tcctgcgacc tgcctccagt gcctcactgt     7020

gagggcggcc tgcagcctac cctgacaaat ccaggcgagt gcagacccaa cttcacctgc     7080

gcctgtcgga aggaggagtg caagagagtg tccccccctt cttgtccacc ccacaggctg     7140

cctaccctgc gcaagacaca gtgctgtgac gagtacgagt gcgcctgtaa ttgcgtgaac     7200

agcaccgtgt cctgcccact gggctatctg gccagcaccg ccacaaacga ttgtggctgc     7260

accacaacca catgtctgcc agacaaggtg tgcgtgcaca ggggaaccat ctacccagtg     7320

ggccagtttt gggaggaggg ctgtgacgtg tgcacctgca cagacatgga ggatgccgtg     7380

atgggcctga gggtggcaca gtgctcccag aagccatgtg aggactcttg cagaagcggc     7440

ttcacctatg tgctgcacga gggcgagtgc tgtggcagat gtctgcctag cgcctgcgag     7500

gtggtgacag gcagcccaag gggcgactcc cagtcctctt ggaagtccgt gggctctcgc     7560

tgggcctccc cagagaatcc ttgtctgatc aacgagtgcg tgagggtgaa ggaggaggtg     7620

tttgtgcagc agcgcaatgt gagctgccca cagctggagg tgcccgtgtg cccatccgga     7680

ttccagctgt cttgcaagac cagcgagtgc tgtccaagct gtaggtgcga gcccgtggag     7740

gcatgtatgc tgaacggcac aatcatcggc cccggcaaga gcgtgatggt ggacgtgtgc     7800

accacatgta ggtgcatcgt gcaggcagga gcaatctccg gcttcaagct ggagtgcaga     7860

aagaccacct gtaagccatg ccccctgggc tacaaggagg agaacaatcc cggagaatgt     7920

tgtggcagat gtctgccaac cgcatgcaca atccagctga ggggaggaca gatcatgacc     7980

ctgaagagag atgagacact gcaggacggc tgtgattccc acttttgcaa agtgaatgag     8040

cggggcgagt acatctggga gaagagagtg accggctgtc ctccattcga cgagcacaag     8100

tgcctggcag agggaggcaa gatcatgaag atccccggca cctgctgtga tacatgtgag     8160

gagcctgagt gcaaggacat caccgccaga ctgcagtatg tgaaagtggg cagctgcaag     8220

tccgaggtgg aggtggacat ccactactgt cagggcaagt gcgcctctaa ggccatgtat     8280

agcatcgaca tcgaggatgt gcaggaccag tgttcttgct gtagcccaac ccggacagag     8340

cccatgagag tgcctctgca ctgcaccaat ggcagcgtgg tgtaccacga ggtgctgaac     8400

gccatgcagt gtaagtgctc cccccggaag tgctctaag                            8439


<210>  2
<211>  8439
<212>  DNA
<213>  Rodent

<400>  2
atgaaccccg cccgctttga gatctggctg ctggccctgg ccctgacctg gccaggcacc       60

ctgtgcaccg agaagacacg ggacagacct tccatggccc ggtgctctct gttcggcgac      120

gacttcatca ataccttcga tgagacaatg tactctttcg ccggaggatg tagctatctg      180

ctggccggcg actgccagaa gcggagcttc agcatcctgg gcaacttcca ggatggcaag      240

cgggtgtccc tgagcgtgta cctgggcgag ttctttgaca tccacctgtt tgccaatggc      300

accgtgatgc agggcgatca gagcatctcc atgccctacg ccagcaaggg cctgtatctg      360

gagacagagg ccggctacta taagctgagc tccgaggcct atggattcgt ggcaaggatc      420

gacggcgatg gaaactttca ggtgctgatg tccgaccggc acttcaataa gacctgtggc      480

ctgtgcggcg atttcaacat ctttgccgag gacgacttcc ggacacagga gggcaccctg      540

acatctgacc cctacgattt cgccaacagc tgggcactgt ctagcggaga gcagcggtgt      600

aagagagcca gccccccttc ctctcactgc aatagctcct ctggcgacat gcagaaggcc      660

atgtgggagc agtgtcagct gctgaagtct gccagcgtgt ttgcccgctg ccaccctctg      720

gtggatccag agcccttcgt ggccctgtgc gagaagaccc tgtgcacatg taccacaggc      780

ccagagtgcg catgtcccgc cctgctggag tacgcacgga cctgcgccca ggagggcatg      840

gtgctgtatg gctggacaga ccacagcgcc tgtagaccag catgccctgc aggcatggag      900

tacaaggagt gcgtgagccc atgcaccagg acatgtcagt ctctgcccat caacgaggtg      960

tgccagcagc agtgcgtgga tggatgcgga tgtcctgagg gagagctgct ggacgaggat     1020

agatgcgtgc agagctccga gtgctcctgc gtgcacgcag gcaagaggta tccacccggc     1080

acctccctgt ctcaggactg taatacatgc atctgtcgca acagcctgtg gatctgctcc     1140

aacgaggagt gcccaggcga gtgtctggtg accggccagt ctcacttcaa gagctttgat     1200

aacagatact tcaccttcag cggcatctgt cagtatctgc tggccaggga ctgccaggat     1260

cacagctttt ccatcgtgat cgagacaatg cagtgtgccg acgatcccga cgccgtgtgc     1320

accagatccg tgacagtgag gctgtctgcc ctgcacaata gcctggtgaa gctgaagcac     1380

ggaggaggag tggcaatcga cggacaggat gtgcagatcc ctttcctgca gggcgacctg     1440

agaatccagc acaccgtgat ggcctccgtg aggctgtctt acggcgagga tctgcagatg     1500

gactgggatg gaaggggccg cctgctggtg aagctgagcc cagtgtactc cggcaagact     1560

tgcggcctgt gcggcaacta taatggcaac aagggcgacg attttctgac accagcaggc     1620

ctggtggagc cactggtggt ggacttcggc aacgcctgga agctgcaggg cgactgtccc     1680

gatctgcaca gacagcactc tgatccttgc agcctgaatc caaggctgac caggtttgca     1740

gaggaggcat gtgcactgct gacatctagc aagttcgagg catgccacca cgccgtgagc     1800

cctctgccat acctgcagaa ctgccgctat gacgtgtgct cttgtagcga cggaagggat     1860

tgcctgtgct ccgccgtggc aaattacgct gccgcctgcg caagaaaggg agtgcacatc     1920

ggatggaggg agccagactt ttgcgcactg ggatgtcctc agggacaggt gtacctgcag     1980

tgcggcaata gctgtaacct gacctgcaga tccctgtctt atcccgatga ggagtgtaac     2040

gaggtgtgcc tggagggctg cttctgtcct ccaggcctgt accaggacga gaggggcgat     2100

tgcgtgccaa aggcacagtg cccttgttac tatgacggcg agctgtttca gccagccgac     2160

atcttctccg atcaccacac catgtgctat tgtgaggacg gcttcatgca ctgcaccaca     2220

tccggcacac caggctctct gctgcccgat atcgtgctgt cctctcccct gtcccaccgg     2280

agcaagagaa gcctgtcctg tcgcccccct atggtgaagc tggtgtgccc agcagacaac     2340

cctagggcac agggcctgga gtgtgcaaag acctgccaga attacgatct ggagtgtatg     2400

agcctgggat gcgtgtccgg atgcctgtgc ccacccggca tggtgagaca cgagaacaag     2460

tgcgtggccc tggagaggtg cccatgtttt caccagggac aggagtatgc accaggcgac     2520

accgtgaaga tcggctgtaa tacatgcgtg tgccgggacc ggagatggaa ttgcaccaac     2580

cacgtgtgcg atgccacatg cagcgccatc ggcatggccc actacctgac ctttgacggc     2640

ctgaagtatc tgttcccagg cgagtgtcag tacgtgctgg tgcaggatta ttgcggctcc     2700

aatccaggca ccttccgcat cctggtgggc aacgagggct gtagctaccc ctccgtgaag     2760

tgcaagaagc gggtgacaat cctggtggag ggcggcgaga tcgagctgtt tgacggcgag     2820

gtgaacgtga agcgccctct gaaggatgag agccacttcg aggtggtgga gtccggccgg     2880

tacgtgatcc tgctgctggg acaggccctg agcgtggtgt gggaccacca cctgtctatc     2940

agcgtggtgc tgaagcacac ctatcaggag caggtgtgcg gcctgtgcgg aaattttgac     3000

ggcatccaga acaatgattt cacaagctcc tctctgcagg tcgaggagga cccagtggat     3060

ttcggcaata gctggaaggt gagctcccag tgtgccgata ccagaaagct gtccctggac     3120

gtgtctcccg ccacctgcca caacaatatc atgaagcaga caatggtgga ctctagctgt     3180

agaatcctga catccgatat ctttcaggga tgcaacaggc tggtggaccc agagccttac     3240

ctggacatct gcatctatga tacctgctct tgtgagagca tcggcgactg cgcctgtttc     3300

tgcgatacaa tcgcagcata cgcacacgtg tgcgcacagc acggacaggt ggtggcatgg     3360

cgcaccccca ccctgtgccc ccagagctgc gaggagagga atgtgcgcga gaacggctac     3420

gagtgcgagt ggcggtataa ttcctgtgca ccagcatgcc cagtgacctg tcagcaccca     3480

gagcccctgg cctgcccagt gcagtgcgtg gagggatgcc acgcacactg tcctccagga     3540

aggatcctgg acgagctgct gcagacctgc gtggaccctc aggattgtcc agtgtgcgag     3600

gtggcaggca ggcgcctggc cccaggcaag aagatcaccc tgagccctga cgatccagcc     3660

cactgccaga attgtcactg cgatggcgtg aacctgacat gtgaggcatg ccaggagcct     3720

ggaggcctgg tggtgccacc taccgacgcc cccgtgagct ctaccacacc atacgtggag     3780

gatacacccg agccacccct gcacaacttt tattgctcca agctgctgga cctggtgttc     3840

ctgctggatg gcagctccag actgtctgag gccgagtttg aggtgctgaa ggccttcgtg     3900

gtgggcatga tggagaggct gcacatctct cagaagcgga tcagagtggc cgtggtggag     3960

taccacgacg gcagccacgc ctatatcgag ctgaaggcca ggaagcgccc ttctgagctg     4020

cggagaatcg ccagccaggt gaagtacgca ggctcccagg tggcctccac ctctgaggtg     4080

ctgaagtata cactgttcca gatctttggc aagatcgata ggccagaggc cagcaggatc     4140

gtgctgctgc tgaccgcctc ccaggagcct ccaaggatgg ccagaaatct ggtgcgctac     4200

gtgcagggcc tgaagaagaa gaaagtgatc gtgatccctg tgggaattgg accacacgcc     4260

tccctgaagc agatccggct gatcgagaag caggcccccg agaacaaggc ctttctgctg     4320

tctggcgtgg atgagctgga gcagaggcgc gacgagatca tcaattatct gtgcgacctg     4380

gcaccagagg cacctgcacc aacccagccc cctcaggtgg cccagatcac agtgtcccct     4440

ggcatcctgg gcatctctag ccccggccct aagagaaagt ctatggtgct ggacgtggtg     4500

ttcgtgctgg agggctctga tgaagtgggc gaggccaact tcaacaagag caaggagttc     4560

ctggaggaag tgatccagag gatggacgtg ggccaggatg gcatccacat ctctgtgctg     4620

cagtacagct ataccgtgac agtggagtac acctttaacg aggcccagag caaggaggac     4680

gtgctgaggc acgtgcgcga gatcaggtac cagggaggca atcgcaccaa cacaggccag     4740

gccctgcagt atctgtccga gcacagcttc tccccttctc agggcgatcg cgagcaggca     4800

ccaaatctgg tgtatatggt gaccggcaac cccgcctctg atgagatcaa gcggctgcct     4860

ggcgacatcc aggtggtgcc aatcggagtg ggacctcacg caaatgcaca ggagctggag     4920

aggatcggat ggccaaacgc acctatcttt atcagagact tcgagacact gcccagggag     4980

gcccctgatc tggtgctgca gcggtgctgt agcagggagg gcctgcagct gccaaccctg     5040

tccccaacac ccgactgctc tcagcccctg gatgtggtgc tgctgctgga cggctcctct     5100

agcctgcccg agtcttactt cgacgagatg aagagctttg ccaaggcctt catctccaag     5160

gccaacatcg gccctcacct gacccaggtg agcgtgctgc agtatggctc catcaataca     5220

atcgatgtgc catggaacgt ggcccaggag aaggcccacc tgctgtccct ggtggacctg     5280

atgcagaggg agggaggacc atctcagatc ggcgatgccc tggcctttgc cgtgcgctac     5340

gtgacctctc agatccacgg agcccggcct ggagccagca aggccgtggt catcctgatc     5400

atggacacct ccctggactc tgtggataca gccgccgatg ccgccagaag caacagggtg     5460

gccgtgttcc caatcggagt gggcgaccgc tatgatgagg cacagctgag gatcctggca     5520

ggacctggag cctcctctaa cgtggtgaag ctgcagcagg tggaggacct gccaaccatg     5580

gtgacactgg gcaatagctt ctttcacaag ctgtgcagcg gcttctccgg cgtgtgcgtg     5640

gacgaggatg gcaatgagaa gcggcccggc gacgtgtgga ccctgcctga ccagtgtcac     5700

accgtgacat gcctgcctaa tggccagaca ctgctgcagt cccacagggt gaactgtgac     5760

cacggacctc ggccaagctg ctccaattct cagagccccg tgagagtgga ggagacatgt     5820

ggctgcaggt ggacatgtcc ttgcgtgtgc accggcagct ccacaagaca catcgtgacc     5880

tttgacggcc agaatttcaa gctgacaggc aactgcagct acgtgctgtt tcagaacaag     5940

gagcaggatc tggaagtgat cctgcacaat ggagcatgtt ccccaggagc aaggcaggca     6000

tgcatgaagt ctatcgaggt gaagcacgca ggcctgtccg tggagctgca ctctgacatg     6060

gagatggcag tgaacggcag actggtgcca gcaccttacg tgggcggcaa tatggaggtg     6120

tccatctacg gcgccatcat gtatgaggtg aggttcaacc acctgggcca catcctgacc     6180

tttacacctc agaacaatga gttccagctg cagctgtctc caaagacctt tgccagcaag     6240

atgtacggcc tgtgcggcat ctgcgacgag aatggcgcca acgacttcat gctgagagat     6300

ggcacagtga ccacagattg gaagaggctg atccaggagt ggaccgtgca gcagcctggc     6360

tatacatgtc agccagtgcc cgaggagcag tgcccagtga gcgactctag ccactgtcag     6420

gtgctgctgt ccgccctgtt tgcagagtgt cacaaggtgc tggccccagc caccttccac     6480

gcaatctgtc agcaggatag ctgccaccag gagagggtgt gcgaagtgat cgcctcctac     6540

gcccacctgt gcagaacaaa tggcgtgtgc gtggactgga ggaccacaga tttttgcgcc     6600

atgagctgtc caccctccct ggtgtataac cactgcgaga gaggctgtcc taggcactgc     6660

gatggcaata cctcctcttg tggcgaccac ccaagcgagg gctgcttttg tccccagcac     6720

caggtcatgc tggagggatc ctgcgtgcca gaggaggcat gtacccagtg cgtgggcgag     6780

gacggcgtga gacaccagtt cctggagaca tgggtgccag atcaccagcc ctgccagatc     6840

tgcgtgtgcc tgagcggcag gaagatcaac tgtaccgcac agccttgccc aaccgcaaga     6900

gcacctacat gtggcccatg cgaggtggcc aggctgaagc agtccgccaa tcagtgctgt     6960

cccgagtacg agtgcgtgtg cgacctggtg aattgcaacc tgcctccagt gccaccttgt     7020

gagggaggcc tgcagccaac cctgacaaac cccggcgagt gcagacctac cttcacatgc     7080

gcctgtagaa aggaggagtg caagagggtg tctccaccca gctgtcctcc acacagaacc     7140

cctacactga ggaagaccca gtgctgtgat gagtacgagt gcgcctgttc ttgcgtgaac     7200

tccacagtgt cttgcccact gggctatctg gccagcgcca ccacaaatga ctgtggctgc     7260

accacaacca catgtctgcc agataaggtg tgcgtgcaca ggggcaccat ctaccccgtg     7320

ggccagtttt gggaggaggg ctgtgacacc tgtacatgca ccgacatgga ggatacagtg     7380

atgggcctga gagtggccca gtgcagccag aagccttgtg aggattcctg ccagccaggc     7440

ttctcttatg tgctgcacga gggcgagtgc tgtggcaggt gtctgccttc cgcctgcaag     7500

gtggtggcag gcagcccaag aggcgactcc cacagctcct ggaagagcgt gggctccagg     7560

tgggcagtgc cagagaatcc ctgtctgatc aacgagtgcg tgcgcgtgga ggaggccgtg     7620

tttgtgcagc agcggaacat ctcttgcccc cagctggccg tgcctacctg tccaacaggc     7680

ttccagctgt cttgcgagac aagcgagtgc tgtcctagct gtcgctgcga gccagtggag     7740

gcctgtctgc tgaatggcac aatcatcggc cctggcaagt ctgtgatggt ggacctgtgc     7800

accacatgtc ggtgcatcgt gcagaccggc gccatcagcc gcttcaagct ggagtgccgg     7860

aagaccacat gtgaggcctg cccaatgggc taccgcgagg agaagaacca gggagagtgc     7920

tgtggccggt gtctgccaac cgcatgcaca atccagctga ggggaggaca gatcatgacc     7980

ctgaagcggg acgagacact gcaggacggc tgtgatagcc acttttgcaa agtgaatgag     8040

cgcggcgagt acatctggga gaagagggtg accggctgtc cacctttcga cgagcacaag     8100

tgcctggcag agggaggcaa gatcatgaag atccccggca cctgctgtga tacatgtgag     8160

gagcctgact gcaaggatat caccgccaag ctgcagtatg tgaaagtggg cgattgcaag     8220

agccaggagg aggtggacat ccactactgt cagggcaagt gcgcctctaa ggccgtgtat     8280

agcatcgaca tcgaggatgt gcaggagcag tgttcctgct gttggccatc taggaccgag     8340

ccaatgaggg tgcctctgca ctgcacaaat ggctccgtgg tgtaccacga agtgatcaac     8400

gccatgcagt gtaggtgcag cccaaggaag tgctccaag                            8439


<210>  3
<211>  8439
<212>  DNA
<213>  Primate/Rodent

<400>  3
atgatcccag cacggctggc cagagtgctg ctggccctgg ccctgacact gcctggcacc       60

ctgtgcacag agggaaccag gggccgcagc tccatggcac ggtgctctct gttcggcgac      120

gacttcatca acaccttcga tgagagcatg tactccttcg ccggcgactg tagctatctg      180

ctggccggcg attgccagaa gcacagcttt tccatcctgg gcgacttcca gaatggcaag      240

agggtgtctc tgagcgtgta cctgggcgag ttctttgata tccacctgtt tgtgaacggc      300

acagtgatgc agggcgacca gcgcgtgagc atgccatacg cctccaaggg cctgtatctg      360

gagacagagg ccggctacta taagctgtct agcgaggcct acggcttcgt ggccaggatc      420

gatggcagcg gcaattttca ggtgctgctg tccgaccgct atttcaacaa gacatgtggc      480

ctgtgcggca acttcaatat ctttgcagag gacgacttcc ggacccagga gggcaccctg      540

acatctgacc cttatgattt cgccaatagc tgggccctgt cctctggaga gcagaggtgt      600

aagagggcca gcccacctag ctccccatgc aacatctcta gcggcgagat gcagaagggc      660

ctgtgggagc agtgtcagct gctgaagagc gccagcgtgt tcgcaaggtg ccacccactg      720

gtggaccctg agccattcgt ggccctgtgc gagaagacac tgtgcacctg tgcacaggga      780

cctgagtgcg catgtccagc cctgctggag tacgcaagag catgcgcaca ggagggaatg      840

gtgctgtatg gctggaccga ccactccgcc tgtaggcctg catgcccagc aggaatggag      900

tacaaggagt gcgtgagccc ctgcaccaga acatgtcagt ctctgcacat caatgaggtg      960

tgccaggagc agtgcgtgga tggctgcagc tgtcctgagg gacagctgct ggacgagggc     1020

cggtgcgtgg agtccgccga gtgctcttgc gtgcacagcg gcaagagata tccacccgga     1080

gccagcctgt cccaggattg taatacctgc atctgtcgga actctctgtg gatctgcagc     1140

aatgaggagt gccccggcga gtgtctggtg acaggccagt cccacttcaa gtcttttgac     1200

aacagatact tcaccttcag cggcatctgt cagtatctgc tggccagaga ctgccaggat     1260

cactctttca gcatcgtgat cgagacagtg cagtgtgcag acgatccaga cgccgtgtgc     1320

acccggtccg tgaccgtgag actgcctgcc ctgcacaact ctctggtgaa gctgaagcac     1380

ggaggaggag tggcaatgga cggacaggat gtgcaggtgc ctctgctgca gggcgatctg     1440

cggatccagc acaccgtgat ggccagcgtg agactgtcct acggcgagga cctgcagatg     1500

gactgggatg gccggggcag actgctggtg aagctgagcc cagtgtacgc cggcaagacc     1560

tgcggcctgt gcggcaacta taatggcaac aagggcgacg attttctgac cccagcaggc     1620

ctggtggagc cactggtgga ggatttcggc aatgcctgga agctgcacgg cgactgtcag     1680

gatctgcaga agcagcactc tgacccctgc agcctgaacc ctcggctgac aagatttgca     1740

gaggaggcat gtgcactgct gacctcctct aagttcgagg catgccacca cgccgtgtcc     1800

ccactgcctt acctgcagaa ttgcagatat gacgtgtgct cctgttctga cggaagggat     1860

tgcctgtgct ccgccgtggc ctcttacgct gccgcctgcg caaggagagg agtgcacatc     1920

gcatggaggg agcctggatt ttgcgcactg agctgtccac agggccaggt gtacctgcag     1980

tgcggcacac cttgtaatct gacctgcaga agcctgtcct atccagatga ggagtgtaac     2040

gaggtgtgcc tggagggctg cttctgtcct ccaggcctgt acctggatga gagaggcgac     2100

tgcgtgccaa aggcacagtg cccatgttac tatgacggcg agatctttca gcctgaggat     2160

atcttcagcg accaccacac aatgtgctat tgtgaggatg gcttcatgca ctgcaccaca     2220

tccggagcac ctggctctct gctgccagac accgtgctga gctccccact gtctcacagg     2280

agcaagcgga gcctgagctg taggccccct atggtgaagc tggtgtgccc tgcagataat     2340

ccaagggcag agggcctgga gtgtgcaaag acctgccaga actacgacct ggagtgtatg     2400

agcatgggat gcgtgtccgg atgcctgtgc ccacccggca tggtgcggca cgagaacaga     2460

tgcgtggccc tggagaggtg cccatgtttt caccagggaa gggagtatgc accaggagag     2520

acagtgaaga tcgactgtaa tacctgcgtg tgcagggatc gcaagtggaa ctgcacagat     2580

cacgtgtgcg acgcaacctg ctccgccatc ggaatggccc actacctgac ctttgatggc     2640

ctgaagtata tgttccccgg cgagtgtcag tacgtgctgg tgcaggacta ttgcggctct     2700

aatccaggca cattcaggat cctggtgggc aacgagggct gtggctaccc cagcgtgaag     2760

tgcaagaagc gcgtgaccat cctggtggag ggaggagaga tcgagctgtt tgatggcgaa     2820

gtgaatgtga agaggcctat gaaggacgag acacacttcg aggtggtgga gagcggccgg     2880

tacgtgatcc tgctgctggg caaggccctg tctgtggtgt gggacaggca cctgggcatc     2940

agcgtggtgc tgaagcagac atatcaggag caggtgtgcg gcctgtgcgg aaattttgat     3000

ggcatccaga acaatgactt cacctctagc aatctgcagg tggaggagga ccccgtggat     3060

ttcggcaact cctggaaggt gtcctctcag tgtgccgaca cacggaaggt gcccctggat     3120

agctcccctg ccacatgcca caacaatatc atgaagcaga ccatggtgga ttctagctgt     3180

agaatcctga ccagcgatat ctttcaggac tgcaataagc tggtggaccc agagccctac     3240

ctggacgtgt gcatctatga cacatgctcc tgtgagtcta tcggcgattg cgcctgtttc     3300

tgcgacacca tcgcagcata cgcacacgtg tgcgcacagc acggcaaggt ggtgacctgg     3360

aggaccgcca ccctgtgccc acagtcctgc gaggagcgga atctgagaga gaacggctac     3420

gagtgcgagt ggagatataa ctcttgtgcc cccgcctgcc ctgtgacatg tcagcaccct     3480

gagccactgg cctgcccagt gcagtgcgtg gagggatgcc acgcacactg tcctccaggc     3540

aagatcctgg acgagctgct gcagacctgc gtggaccccg aggattgtcc cgtgtgcgag     3600

gtggcaggca ggcgcctggc cccaggcaag aaggtgacac tgaatccatc cgatcccaag     3660

cactgccaga tctgtcactg cgacggcgtg aacctgacct gtgaggcctg ccaggagcca     3720

ggaggcctgg tggtgccacc tacagaggcc cctgtgagcc caaccacacc ctacgtggag     3780

gacacccctg agccacccct gcacgacttc tactgcagca agctgctgga tctggtgttc     3840

ctgctggacg gctcctctaa gctgtccgag gccgagtttg aggtgctgaa ggccttcgtg     3900

gtgggcatga tggagagact gcacatctct cagaagcgga tcagagtggc cgtggtggag     3960

taccacgatg gcagccacgc ctatatcgag ctgaaggaca ggaagcgccc ctctgagctg     4020

cggagaatcg ccagccaggt gaagtacgcc ggctcccagg tggcctccac atctgaggtg     4080

ctgaagtata ccctgttcca gatctttggc aagatcgaca ggcctgaggc cagcaggatc     4140

gccctgctgc tgaccgcctc ccaggagcct ccaaggatgg cacgcaacct ggtgaggtac     4200

gtgcagggcc tgaagaagaa gaaagtgatc gtgatcccag tgggaatcgg accacacgcc     4260

aatctgaagc agatccgcct gatcgagaag caggcccctg agaacaaggc ctttgtgctg     4320

tccggagtgg acgagctgga gcagaggagg gatgagatca tcaattatct gtgcgacctg     4380

gcaccagagg caccagcacc tacacagcca cctcagatgg cacaggtgac cgtgggacct     4440

ggcctgctgg gcgtgagccc acccggccca aagcggaact ccatggtgct ggatgtggtg     4500

ttcgtgctgg agggcagcga caagatcgga gaagccaact tcaaccggag caaggagttc     4560

atggaggaag tgatccagag aatggatgtg ggccaggacg gcatccacgt gaccgtgctg     4620

cagtacagct atatggtgac agtggagtac acctttagcg aggcccagtc caagggcgat     4680

gtgctgcagc gggtgagaga gatccggtac cagggcggca atagaaccaa cacaggcctg     4740

gccctgcagt atctgtccga gcacagcttc tccgcctctc agggcgaccg ggagcaggca     4800

ccaaatctgg tgtatatggt gaccggcaac cccgccagcg acgagatcaa gagactgcct     4860

ggcgatatcc aggtggtgcc tatcggagtg ggaccacacg ccaatgtgca ggagctggag     4920

agaatcggct ggcctaacgc cccaatcctg atccaggatt ttgagacact gccaagggag     4980

gcaccagacc tggtgctgca gcggtgctgt tccggagagg gcctgcagat ccccaccctg     5040

tctccagccc ccgattgcag ccagcctctg gacgtggtgc tgctgctgga tggcagctcc     5100

tctagccccg cctcttactt cgatgagatg aagagctttg ccaaggcctt catctccaag     5160

gccaatatcg gccctcacct gacccaggtg tccgtgctgc agtatggctc tatcaccaca     5220

atcgacgtgc catggaacgt ggcccaggag aaggcccacc tgctgtctct ggtggatctg     5280

atgcagaggg agggaggacc aagccagatc ggcgacgcac tgggatttgc cgtgcggtac     5340

atcacatccg aggtgcacgg agccagaccc ggagcctcta aggccgtggt catcctggtg     5400

acagatgtga gcaccgactc cgtggatgct gccgccgacg cagcacggag caatagagtg     5460

accgtgttcc ccatcggcat cggcgacagg tatgacgagg cacagctgag gatcctggca     5520

ggacctgagg cctcctctaa tgtggtgaag ctgcagcgca tcgaggacct gccaacaatg     5580

gtgaccctgg gcaactcttt tctgcacaag ctgtgcagcg gcttcgtgag gatctgcatg     5640

gacgaggatg gaaacgagaa gcgccccggc gacgtgtgga cactgcctga tcagtgtcac     5700

accgtgacat gcctgcccga tggccagacc ctgctgaagt cccacagggt gaattgtgac     5760

aggggacctc gcccatcttg cccaaacagc cagtccccta tccgggtgga ggagacatgt     5820

ggctgcagat ggacctgtcc ttgcgtgtgc atgggcagct ccacacgcca catcgtgacc     5880

tttgatggcc agaacttcaa gctgaccggc tcttgcagct acgtgctgtt ccagaataag     5940

gagcaggacc tggaagtgat cctgcacaac ggagcatgta gcccaggagc aaggcagaca     6000

tgcatgaagt ccatcgaggt gaagcacgat ggcctgtctg tggagctgca cagcgacatg     6060

gaggtgaccg tgaatggcag gctggtgagc gtgccatacg tgggaggcaa tatggaggtg     6120

aacatctatg gcgccatcat gcacgaggtg cgctttaacc acctgggcca catcttcacc     6180

tttacaccac agaacaatga gtttcagctg cagctgagcc ccaagacctt cgcctccaag     6240

atgtatggcc tgtgcggcat ctgcgatgag aatggcgcca acgatttcat gctgcgggac     6300

ggcacagtga ccacagactg gaagacactg atccaggagt ggaccgtgca gcagccagga     6360

cagacctgtc agcccgtgcc tgaggagcag tgccccgtgt ctgattctag ccactgtcag     6420

gtgctgctga gcgccctgtt tgcagagtgt cacaaggtgc tggccccagc cacattctac     6480

gccatctgtc agcaggacag ctgccacaga gagcaggtgt gcgaagtgat cgcctcctat     6540

gcacacctgt gcaggaccaa cggcgtgtgc gtggattgga gaaccacaga cttttgcgcc     6600

atgtcttgtc ctccaagcct ggtgtacaat cactgcgaga ggggatgtcc taggcactgc     6660

gacggcaaca cctcctcttg tggcgatcac ccatccgagg gctgcttttg tccccctcac     6720

caggtcatgc tggagggatc ttgcgtgcca gaggaggcat gtacacagtg cgtgggagag     6780

gatggcgtgc gccaccagtt cctggagaca tgggtgcctg accaccagcc atgccagatc     6840

tgcacatgtc tgtctggccg gaaagtgaat tgtaccagcc agccatgccc aacagcaaga     6900

gcaccaacct gtggaccttg cgaggtggca aggctgaggc agaacgcaga ccagtgctgt     6960

cccgagtacg agtgcgtgtg cgatctggtg tcctgcgacc tgccacccgt gcctcactgt     7020

gagggaggcc tgcagccaac cctgacaaat cccggcgagt gcaggcctaa cttcacctgc     7080

gcctgtcgca aggaggagtg ccggagagag tctcctccaa gctgtccccc tcaccggacc     7140

ccaacactga gaaagacaca gtgctgtgac gaatacgagt gcgcctgtaa ttgcgtgaac     7200

tccaccgtgt cttgcccact gggatatctg gccagcgcca ccacaaacga ttgtggctgc     7260

accacaacca catgtctgcc tgacaaggtg tgcgtgcaca ggggcaccat ctacccagtg     7320

ggccagtttt gggaggaggg ctgtgacgtg tgcacctgca cagacatgga ggatgccgtg     7380

atgggcctga gggtggcaca gtgctcccag aagccatgtg aggactcttg cagacccggc     7440

ttcacatacg tgctgcacga gggcgagtgc tgtggcaggt gtctgccatc cgcctgcgag     7500

gtggtgaccg gctctcctag gggcgattcc cagtcttatt ggaagagcgt gggctcccac     7560

tgggcctccc cagagaatcc ttgtctgatc aacgaatgcg tgagggtgaa ggaggaggtg     7620

tttgtgcagc agcgcaacgt gagctgccca cagctggacg tgccaacatg tcccaccggc     7680

ttccagctgt cctgcaagac ctctgagtgc tgtcctagct gtcgctgcga gccagtggag     7740

gcctgtatgc tgaacggcac aatcatcggc cctggcaaga gcgtgatgat cgacgtgtgc     7800

accacatgtc actgcaccgt gcaagtggga gcaatctccg gcttcaagct ggagtgcagg     7860

aagaccacat gtgaggcctg cccactgggc tacaaggagg agaagaatca gggagagtgc     7920

tgtggccgct gtctgccaac agcatgcacc atccagctga ggggaggaca gatcatgaca     7980

ctgaagcgcg atgagacact gcaggacggc tgtgatagcc acttttgcaa ggtgaacgag     8040

cggggcgagt acatctggga gaagagagtg acaggctgtc cacccttcga cgagcacaag     8100

tgcctggcag agggaggcaa gatcatgaag atcccaggca catgctgtga tacctgtgag     8160

gagcccgagt gcaaggacat caccgcccgg ctgcagtatg tgaaagtggg cgactgcaag     8220

tccgaagagg aggtggatat ccactactgt cagggcaagt gcgcctccaa ggccgtgtat     8280

tctatcgaca cagaggatgt gcaggaccag tgttcttgct gtagccccac caggacagag     8340

ccaatgcgcg tgcccctgca ctgcaccaat ggcagcgtgg tgtaccacga ggtgctgaac     8400

gccatgcagt gtaagtgcag ccctaggaag tgctccaag                            8439


<210>  4
<211>  8436
<212>  DNA
<213>  Ungulate

<400>  4
atgatccctg caagactggc cagggtgctg ctggccctgg ccctgacact gccaggcgcc       60

ctgtgcggag agggcaccct gggccgcagc tccatggcaa ggtgctccct gttcggcgac      120

gacttcatca ataccttcga tgagtccatg tactctttcg ccggctcttg tagctatctg      180

ctggccggcg actgccagaa gcactccttt tctctgatcg gcgacttcca ggatggcaag      240

cgggtgagcc tgtccgtgta cctgggcgag ttctttgata tccacctgtt tgtgaacggc      300

acagtgctgc agggcgacca gtctgtgagc atgccctacg ccagcaaggg cctgtatctg      360

gagacagagg ccggctacta taagctgtct agcgaggcct acggcttcgt ggccagaatc      420

gatggctctg gcaattttca ggtgctgctg agcgacaggt atttcaacaa gacatgtggc      480

ctgtgcggca acttcaatat ctttgcagag gacgacttcc ggacccagga gggcaccctg      540

acatccgacc cttatgattt cgccaattct tgggccctgt cctctggaga gcagcggtgc      600

cagagggcca gcccacctag ctcctcttgc aacgtgagct ccgagatgca gaagggcctg      660

tgggagcagt gtcagctgct gaagagcgcc agcgtgttcg caaggtgcca cccactggtg      720

gatcctgagc cattcgtggc cctgtgcgag aagatgctgt gcacatgtgc acagggcctg      780

cagtgcccat gtcctgtgct gctggagtac gcaagggcat gcgcacagca gggcatggtg      840

ctgtatggct ggaccgacca ctccgcctgt aggccagcat gcccagcagg catggagtac      900

aaggagtgcg tgagcccttg cacccggaca tgtcagtccc tgcacatcaa tgaggtgtgc      960

caggagcagt gcgtggatgg ctgcagctgt ccagagggac agctgctgga cgagggccgc     1020

tgcgtggagt ctgccgagtg cagctgcgtg cactccggca agcggtaccc accaggagcc     1080

agcctgtccc gcgattgtaa tacctgcatc tgtcggaact ccctgtgggt gtgctctaat     1140

gaggagtgcc ccggcgagtg tctggtgaca ggccagtctc acttcaagag ctttgacaac     1200

cgccacttca ccttttccgg cgtgtgccag tatctgctgg ccagggactg ccaggatcac     1260

tctttcagcg tgatcatcga gacagtgcag tgtgccgacg atccagacgc cgtgtgcaca     1320

agaagcgtga ccgtgaggct gccatccccc cacaactctc tggtgaagct gaagcacgga     1380

ggaggagtgg caatggacgg acaggatgtg cagatccccc tgctgcaggg cgatctgcgg     1440

atccagcaca ccgtgatggc cagcgtgcac ctgagctacg gcgaggacct gcagatcgac     1500

tgggatggaa ggggccgcct gctggtgaag ctgagccccg tgtacgccgg cagaacctgc     1560

ggcctgtgcg gcaactataa tggcaacagg ggcgacgatt ttctgacccc agcaggcctg     1620

gtggagcctc tggtggagca cttcggcaat gcctggaagc tgagaggcga ctgtgaggat     1680

ctgcagaagc agccttctga cccatgcagc ctgaacccaa gactgacaag gtttgccgag     1740

gaggcctgtg ccatcctgac ctctcccaag ttcgaggcat gccacagcgc cgtgggacct     1800

ctgccatacc tgcagaattg ccgctatgac gtgtgctcct gttctgacgg aagggattgc     1860

ctgtgcgacg cagtggccaa ctacgctgcc gcctgcgcaa ggagaggagt gcacatcgca     1920

tggagggagc caggattttg cgcactgtcc tgtccacagg gacaggtgta cctgcagtgc     1980

ggaacaccct gtaatctgac ctgccggagc ctgtcctatc ctgatgagga gtgtaacgag     2040

gtgtgcctgg agggctgctt ctgtcctcca ggcctgtacc tggatgagag cggcgactgc     2100

gtgccaaagg cacagtgccc ttgttactat gacggcgaga tctttcagcc tgaggatatc     2160

ttcagcgacc accacaccat gtgctattgt gaggatggct tcatgcactg ctctacaagc     2220

ggagcaccag gctccctgct gccagacacc gtgctgtcta gcccactgag ccaccgctcc     2280

aagcggtccc tgtcttgtag accccctatg gtgaagctgg tgtgcccagc agataatcct     2340

agggcagagg gcctggagtg tgccaagaca tgccagaact acgacctgga gtgcgtgagc     2400

accggctgcg tgtccggatg cctgtgccca cccggcatgg tgcgccacga gaacagatgc     2460

gtggccctgg agagatgccc ctgttttcac cagggcaggg agtatgcccc tggcgagaca     2520

gtgaagatcg actgtaatac ctgcgtgtgc cgggatagaa agtggaactg cacagatcac     2580

gtgtgcgacg ccagctgctc cgccctgggc ctggcccact acctgacctt tgatggcctg     2640

aagtatctgt tccccggcga gtgtcagtac gtgctggtgc aggactattg cggctctaat     2700

cccggcacat tcaggatcct ggtgggcaac gagggctgtg gctaccctag cctgaagtgc     2760

aggaagaggg tgaccatcct ggtggaggga ggagagatcg agctgtttga tggcgaggtg     2820

tccgtgaagc ggcccatgaa ggacgagaca cacttcgagg tggtggagtc tggcaggtac     2880

atcaccgtgc tgctgggcaa ggccctgagc gtggtgtggg acaggcacct gggcatctcc     2940

gtgtttctga agcagacata tcaggagcag gtgtgcggcc tgtgcggcaa tttcgatggc     3000

gtgcagaaca atgacctgac ctcctctagc ctgcaggtgg aggaggaccc agtggatttc     3060

ggcaactcct ggaaggtgtc tccccagtgt gccgacacaa gaaaggtgcc tctggattcc     3120

tctccagcca catgccacaa caatgtgatg aagcagacca tggtggatag ctcctgtagg     3180

atcctgacct ccgatatctt tcaggactgc aacaagctgg tggaccccga gccttacctg     3240

gacgtgtgca tctatgacac atgctcttgt gagagcatcg gcgattgcgc ctgtttctgc     3300

gacaccatcg cagcatacgc acacgtgtgc gcacagcacg gcaaggtggt gacctggagg     3360

accgccaccc tgtgcccaca gaattgcgag gagagaaatc tgagggagaa cggctacgag     3420

tgcgagtggc ggtataacag ctgtgccccc gcctgccctg tgacatgtca gcacccagag     3480

cccctggcct gcccagtgca gtgcgtggag ggatgccacg cacactgtcc tccaggcaag     3540

atcctggacg agctgctgca gacctgcgtg gacccagagg attgtcccgt gtgcgaggtg     3600

gcaggcaggc gcctggcccc aggcaagaag atcacactga atccaggcga tcccgagcac     3660

tgccagatct gtcactgcga cggcgtgaac ctgacctgtg aggcctgcag ggagccagga     3720

ggcctggagg tgccacctac agagggccct gtgagcccaa ccacacccta cgtggaggac     3780

acccctgagc cacccctgca cgatttcttt tgcagcaagc tgctggatct ggtgttcctg     3840

ctggacggct ctagcaagct gagcgaggcc gactttgagg tgctgaaggc cttcgtggtg     3900

ggcatgatgg agcgcctgca catctctcag aagcggatca gagtggccgt ggtggagtac     3960

cacgatggca gccacgccta tatcgccctg agggaccgca agcggccctc cgagctgagg     4020

agaatcgcct ctcaggtgaa gtacgccggc agcgaggtgg cctctacaag cgaggtgctg     4080

aagtataccc tgttccagat ctttggcaag atcgacaggc ctgaggcctc tagggtggcc     4140

ctgctgctga cagccagcca ggagcctcca cgcctggcca ggaatctggt gagatacgtg     4200

cagggcctga agaagaagaa ggtgaccgtg atccccgtgg gaatcggacc tcacgcctcc     4260

ctgaagcaga tcaggctgat cgagaagcag gcccccgaga acaaggcctt tgtgctgagc     4320

ggagtggacg agctggagca gaggagggat gagatcatct cctatctgtg cgacctggca     4380

cctgaggtgc ctgcaccaac acagcggccc ctggtggcac aggtgaccgt ggcccccgag     4440

ctgctgggcg tgagcacact gggccctaag aggtcctcta tggtgctgga tgtggtgttc     4500

gtgctggagg gaagcgacaa agtgggagaa gccaacttca accggagcac cgagttcgtg     4560

gaggaagtga tccggagaat ggatgtgggc cgggactccg tgcacgtgac agtgctgcag     4620

tactcttatg tggtgaccgt ggagtactct tttagagagg cccagagcaa gggcgatgtg     4680

ctgcagagag tgagggagat ccgctaccag ggcggcaatc ggaccaacac aggcctggcc     4740

ctgcagtatc tgtccgagca ctccttctct gccagccagg gcgacaggga gcaggcacca     4800

aatctggtgt atatggtgac cggcaaccct gccagcgacg agatcaggcg catgccaggc     4860

gatatccagg tggtgccaat cggagtggga ccacacgtgg acgtgcagga gctggagagg     4920

atcggatggc ctaacgcacc aatctttatc caggatttcg agacactgcc tagggaggca     4980

ccagacctgg tgctgcagcg gtgctgttcc ggcgagggac cacacctgcc taccctgtcc     5040

ccagcacctg attgctctca gccactggac gtggtgctgc tgctggatgg cagctcctct     5100

agccctgcct cctacttcga tgagatgaag tcttttgcca aggccttcat cagcaaggcc     5160

aatatcggcc ctcagctgac ccaggtgagc gtgctgcagt atggctccat caccacaatc     5220

gacgtgccat ggaacgtggc ccaggagaag gcccacctgc tgtccctggt ggatctgatg     5280

cagagggagg gaggaccatc tcagatcggc gacgccctgg gctttgccgt gagatacgtg     5340

acctctgagg tgcacggagc caggcccgga gccagcaagg ccgtggtcat cctggtgacc     5400

gatacatcca ccgactctgt ggatgctgcc gccgccgccg ccagaagcaa tagggtggcc     5460

gtgttcccaa tcggaatcgg cgaccgctat gatgaggcac agctgcggac cctggccgga     5520

cctggagcct cctctaatgt ggtgaagctg cagagaatcg aggacctgcc aacaatggtg     5580

accctgggca actcctttct gcacaagctg tgctctggct tcgtgagggt gtgcgtggac     5640

gaggatggaa acgagagacg gcccggcgac gtgtggacac tgccagatca gtgtcacaca     5700

gtgacctgcc tgcccgatgg ccagaccctg ctgaagagcc accgcgtgaa ttgtgaccag     5760

ggaccacggc cctcctgccc taactcccag tctccaatca gagtggagga gacatgtggc     5820

tgcaggtgga cctgtccttg cgtgtgcaca ggcagctcca cccgccacat cgtgacattt     5880

gatggccaga acttcaagct gaccggcagc tgctcctacg tgctgttcca caataaggag     5940

caggacctgg aagtgatcct gcacaacgga gcatgttccg ccggagcaag gcaggcctgc     6000

atgaagtcta tcgaggtgaa gcacaatggc ctgtctgtgg agctgcacag cgacatggag     6060

gtggtggtga atggccgcct ggtgtctgtg ccatacgtgg gaggcaacat ggaggtgagc     6120

atctacggca caatcatgta tgaggtgcgg tttaaccacc tgggccacat cttcaccttc     6180

acccctcaga acaatgagtt tcagctgcag ctgtctccaa agaccttcgc cagcaagatg     6240

tatggcctgt gcggcatctg cgatgagaat ggcgccaacg atttcatgct gagagacggc     6300

acagtcacca cagactggaa gacactggtg caggagtgga ccgtgcagca gccaggccag     6360

acctgtcagc ctgtgccaga ggagcagtgc cccgtgagcg gaggctccca ctgtcaggtg     6420

ctgctgtccg ccctgtttgc cgagtgtcac aaggtgctgg cccctgccac cttccacgcc     6480

atctgtcagc aggactcttg ccaccaggag caggtgtgcg aggccatcgc cagctacgcc     6540

cacctgtgca gaacaaaggg cgtgtgcgtg gattggagga ccccagactt ttgcgccgtg     6600

agctgtcccc cttccctggt gtataatcac tgcgagcacg gatgtccaag gcactgcgag     6660

ggcaactcta gctcctgtgg cgatcacccc agcgagggct gcttttgtcc accccaccag     6720

gtcatgctgg agggatcctg cgtgccagag gaggcatgta cccagtgcgt gtctgacgat     6780

ggcatcagac accagttcct ggagacatgg gtgcccgacc accagccttg ccagatctgc     6840

acctgtctgt ccggccgcaa agtgaattgt acatctcagc cctgccctac cgcaagggca     6900

ccagcatgtg gaccatgcga ggtggcccgc ctgcggcaga acgcccagca gtgctgtccc     6960

gagtacgagt gcgtgtgcga tctggtgagc tgcgacctgc ctccagtgcc tcactgtgag     7020

ggaggcctgc agcccacact gaccaatcct ggcgagtgca ggccaaactt cacctgcgcc     7080

tgtagaaagg aggagtgccc taggggacca cctccatcct gtccacctca cagaacacca     7140

gccctgagga agacccagtg ctgtgacgag tacgagtgcg cctgtaattg cgtgaactct     7200

accgtgagct gccccctggg ctatctggcc agcacagtga ccaacgattg tggctgcacc     7260

acaaccacat gtctgccaga caaggtgtgc gtgcacaggg gaaccatcta ccctgtgggc     7320

cagttttggg aggagggctg tgacgtgtgc acatgcaccg acctggagga tgccgtgatg     7380

ggcctgaggg tggcacagtg cagccagaag ccatgtgagg actcctgccg gcctggcttc     7440

acatacgtgc tgcacgaggg cgagtgctgt ggcagatgtc tgccaagcgc ctgcgaggtg     7500

gtgaccggct cccccagggg cgattctcag agctattgga agtccgtggg ctctcactgg     7560

gcctctccag agaatccctg tctgatcaac gagtgcgtgc gcgtgaagga ggaggtgttt     7620

gtgcagcagc ggaatgtgag ctgcccacag ctggacgtgc ctacctgtcc agtgggcttc     7680

cagctgtctt gcaagacaag cgagtgctgt ccaacctgta ggtgcgagcc cgtgcaggca     7740

tgcgtgctga acggaacaat catcggcccc ggcaagtccc tgatgatcga cgtgtgcacc     7800

acatgtagat gcaccgtgca ggagggcgtg gtgtctggct ttaagctgga gtgcaggaag     7860

accacatgtg aggcctgccc actgggctac aaggaggaga agatgcaggg agaatgttgt     7920

ggcagatgtc tgcccacagc atgcaccatc cagctgaggg gaggacagat catgacactg     7980

aagcgggatg agacactgca ggacggctgt gatagccact tttgcagagt gaatgagagg     8040

ggcgagtaca tctgggagaa gagagtgatg ggctgtccac ccttcgacga gcacaagtgc     8100

ctggcagagg gaggcaagat catgaagatc cctggcacat gctgtgatac ctgtgaggag     8160

ccagagtgca aggacatcac cgccaggctg cagtatgtga aagtgggcga ctgcaagtcc     8220

gaagaggagg tggatatcca ctactgtcag ggcaagtgca catccaaggc cgtgtattct     8280

atcgacaccg aggatgtgca ggaccagtgt agctgctgtt cccccacaag aaccgagcct     8340

atgcaggtgc cactgaggtg caccaatggc agcatcatcc accacgaggt gctgaacgcc     8400

atgcagtgta agtgcagccc tagaaagtgc tccaag                               8436


<210>  5
<211>  8439
<212>  DNA
<213>  Eutheria

<400>  5
atgatccctg cacggctggc cagagtgctg ctggccctgg ccctgacact gccaggcacc       60

ctgtgcacag agggaacccg gggcagaagc tccatggcaa ggtgctctct gttcggcgac      120

gacttcatca acaccttcga tgagtctatg tacagcttcg ccggcgactg tagctatctg      180

ctggccggcg attgccagaa gcacagcttt tccatcctgg gcgacttcca gaatggcaag      240

cgcgtgtctc tgagcgtgta cctgggcgag ttctttgata tccacctgtt tgtgaacggc      300

acagtgatgc agggcgacca gtccgtgtct atgccctacg cctccaaggg cctgtatctg      360

gagacagagg ccggctacta taagctgtct agcgaggcct acggcttcgt ggccaggatc      420

gatggcagcg gcaattttca ggtgctgctg tccgaccgct atttcaacaa gacatgtggc      480

ctgtgcggca acttcaatag gtttgccgag gacgattttc gcacccagga gggcaccctg      540

acatctgacc cctatgattt cgccaatagc tgggccctgt cctctggaga gcagaggtgt      600

aagagggcca gcccacctag ctccccttgc aacatctcta gcggcgagat gcagaagggc      660

ctgtgggagc agtgtcagct gctgaagagc gcctccgtgt ttgcaaggtg ccacccactg      720

gtggatccag agcctttcgt ggccctgtgc gagaagacac tgtgcacctg tgcacaggga      780

ccagactgcc cttgttccgc cctgctggag tacgcaaggg catgcgccca gcagggcatg      840

gtgctgtatg gctggacaga ccactctacc tgtaggccag catgcccagc aggaatggag      900

tacaaggagt gcgtgagccc atgcaccaga acatgtcagt ctctgcacat caatgaggtg      960

tgccaggagc agtgcgtgga tggatgctcc tgtccagagg gacagctgct ggacgagggc     1020

cggtgcgtgg agtccgccga gtgctcttgc gtgcacagcg gcaagagata tccacccggc     1080

tcctctctga gccaggattg taatacctgc atctgtcgga actccctgtg gatctgctct     1140

aatgaggagt gccccggcga gtgtctggtg acaggccagt cccacttcaa gtcttttgac     1200

aacagatact tcaccttcag cggcatctgt cagtatctgc tggccagaga ctgccaggat     1260

cactctttca gcatcgtgat cgagacagtg cagtgtgccg acgatcctga cgccgtgtgc     1320

acccggagcg tgaccgtgag actgccaagc ctgcacaact ccctggtgaa gctgaagcac     1380

ggaggaggag tggcaatgga cggacaggat gtgcagatcc ccctgctgca gggcgatctg     1440

aggatccagc acaccgtgat ggcctctgtg cgcctgagct acggcgagga cctgcagatg     1500

gactgggatg gaaggggccg cctgctggtg aagctgagcc ccgtgtacgc cggcaagacc     1560

tgcggcctgt gcggcaacta taatggcaac aagggcgacg attttctgac cccaagcggc     1620

ctggtggagc ctctggtgga ggatttcggc aattcctgga agctgcacgg cgactgtcag     1680

gatctgcaga agcaggacag cgatccatgc aatctgaacc cccggctgac aagatttgca     1740

gaggaggcat gtgcactgct gaccagctcc aagttcgagg catgccacca cgccgtgagc     1800

ccacagccat acctgcagaa ctgccactat gacgtgtgct cctgttctga cggaagggat     1860

tgcctgtgct ccgccgtggc ctcctacgcc tctgcctgcg caaggaaggg agtgcacatc     1920

gcatggagag agccaggctt ttgcgccctg tcctgtcctc agggccaggt gtacctgcag     1980

tgcggcacac cctgtaatct gacctgccgg agcctgtcct atcctgatga ggagtgtaac     2040

gaggtgtgcc tggagggctg cttctgtcct ccaggcctgt acctggatga gagaggcgac     2100

tgcgtgccta aggcccagtg cccatgttac tatgacggcg agatctttca gcccgaggat     2160

atcttcagcg accaccacac catgtgctat tgtgaggatg gcttcatgca ctgcaccaca     2220

agcggcctgc caggctccct gctgcctgac gtggtgctgt ctagccctct gagccacagg     2280

tccaagcgga gcctgagctg taggccccct atggtgaagc tggtgtgccc agcagataat     2340

ccaagggcag agggcctgga gtgtgcaaag acatgccaga actacgacct ggagtgtatg     2400

tctaccggct gcgtgagcgg atgcctgtgc ccaccaggaa tggtgaggca cgagaatcgc     2460

tgcgtggccc tggagcggtg cccttgtttt caccagggca aggagtatgc cccaggcgag     2520

acagtgaaga tcgactgtaa cacctgcgtg tgccgggata gaaagtggaa ttgcacagat     2580

aacgtgtgcg acgccacctg cagcgtgatc ggcatggccc actacctgac ctttgatggc     2640

ctgaagtata tgttccccgg cgagtgtcag tacgtgctgg tgcaggacta ttgcggcagc     2700

aatcccggca cattcaggat cctggtgggc aacgagggct gtggctaccc ttccgtgaag     2760

tgcaagaagc gcgtgaccat cctggtggag ggaggagaga tcgagctgtt tgatggcgag     2820

gtgaacgtga agaggcctat gaaggacgag acacacttcg aggtggtgga gagcggccgg     2880

tacgtgatcc tgctgctggg caaggccctg tctgtggtgt gggaccacca cctgggcatc     2940

agcgtggtgc tgaagcagac atatcaggag caggtgtgcg gcctgtgcgg caattttgat     3000

ggcatccaga acaatgactt cacctcctct aacctgcagg tggaggagga cccagtcgac     3060

tttggaaatt cctggaaggt gaacccccag tgtgccgaca cacggaaggt gccactggat     3120

agctcccccg ccacatgcca caacaatatc atgaagcaga ccatggtgga ttctagctgt     3180

agaatcctga ccagcgatat ctttcaggac tgcaataagc tggtggaccc tgagccatac     3240

ctggacgtgt gcatctatga cacatgctct tgtgagagca tcggcgattg cgcctgtttc     3300

tgcgacacca tcgcagcata cgcacacgtg tgcgcacagc acggcaaggt ggtgacctgg     3360

aggaccgcca ccctgtgccc tcagtcttgc gaggagcgga atctgagaga gaacggctac     3420

gagtgcgagt ggagatataa cagctgtgcc cctgcctgcc cagtgacatg tcagcaccca     3480

gagcctctgg cctgcccagt gcagtgcgtg gagggatgcc acgcacactg tcctccaggc     3540

aagatcctgg acgagctgct gcagacctgc atcgaccctg aggattgtcc agtgtgcgag     3600

gtggcaggcc ggagactgcc acctggcaag aaggtgacac tgaatccctc cgatcctaag     3660

cactgccaga tctgtcactg cgacggcgtg aacctgacct gtgaggcatg ccaggagcca     3720

ggaggcctgg tgctgccacc aacagaggcc ccagtgagcc caaccacacc ttacgtggag     3780

gacacccccg agcctccact gcacgacttc tactgctcta agctgctgga tctggccttc     3840

ctgctggacg gctcctctaa gctgagcgag gccgagtttg aggtgctgaa ggccttcgtg     3900

gtgggcatga tggagaggct gcacatcagc cagaagagga tccgcgtggc cgtggtggag     3960

taccacgatg gctcccactc ttatatcgag ctgaaggaca ggaagcggcc ctccgagctg     4020

aggcgcatcg cctctcaggt gaagtacgca ggcagccagg tggccagcac atccgaggtg     4080

ctgaagtata ccctgttcca gatctttggc aaggcagaca ggccagaggc ctccaggatc     4140

gccctgctgc tgaccgcctc tgaggagcca cctaggatgg cacgcaacct ggtgaggtac     4200

gtgcagggcc tgaagaagaa gaaagtgatc gtgatccctg tgggaatcgg accacacgcc     4260

agcctgaagc agatccgcct gatcgagaag caggcccccg agaataaggc ctttgtgctg     4320

tccggagtgg acgagctgga gcagaggaga gatgagatca tcaactatct gtgcgacctg     4380

gcacctgagg caccagcacc aacacagcca ccacagatgg cacaggtgac cgtgggacca     4440

ggcctgctgg gcgtgagccc tccaggacct acacgcagct ccatggtgct ggatgtggtg     4500

ttcgtgctgg agggctctga caagatcgga gaagccaact tcaaccggag caaggagttc     4560

atggaggaag tgatccagag aatggatgtg ggccaggaca gcatccacat caccgtgctg     4620

cagtactcct atatggtgac agtggagtac accttttccg aggcccagtc taagggcgat     4680

atcctgcaga gggtgcgcga gatcaggtac cagggaggca atagaaccaa cacaggcctg     4740

gccctgcagt atctgtccga gcactctttc agcacatccc agggcgacag ggagcaggca     4800

ccaaatctgg tgtatatggt gaccggcaac ccagcctctg acgagatcaa gcgcctgcca     4860

ggcgatatcc aggtggtgcc aatcggagtg ggacctcacg ccaatgtgca ggagctggag     4920

cggatctcct ggccaaacgc ccccatcctg atccaggatt ttgagacact gcccagagag     4980

gcccctgacc tggtgctgca gaggtgctgt agcggagagg gcctgaggat ccctaccctg     5040

tcccctgccc cagattgctc tcagccactg gacgtggtgc tgctgctgga tggctctagc     5100

tccgtgcccg cctcctactt cgaggagatg aagtcttttg ccaaggcctt catcagcaag     5160

gccaatatcg gaccacacct gacccaggtg agcgtgctgc agtatggctc catcaccaca     5220

atcgacgtgc cttggaacgt ggcccaggag aaggcccacc tgctgtccct ggtggatctg     5280

atgcagaggg agggaggacc ttctcagatc ggcgacgcac tgggatttgc cgtgcggtac     5340

atcacatccg aggtgcacgg agccagacca ggagcctcta aggccgtggt catcctggtg     5400

accgacgtga gcatggactc tgtggatgct gccgccgacg cagcacggtc caatagagtg     5460

accgtgttcc ccatcggcat cggcgacaga tacgatgagt ctcagctgag aatcctggcc     5520

ggcccagagg cctctagcaa tgtggtgaag ctgcagagaa tcgaggacct gcccacaatg     5580

gtgaccctgg ataactcctt tctgcacaag ctgtgctctg gcttcgtgag ggtgtgcatg     5640

gacgaggatg gcaacgagaa gcgccctggc gacgtgtgga cactgccaga tcagtgtcac     5700

accgtgacat gcctgccaga tggccagacc ctgctgaaga gccaccgggt gaattgtgac     5760

agaggcccca agccttcctg cccaaactct cagagcccca tccgggtgga ggagacatgt     5820

ggctgcagat ggacctgtcc ctgcgtgtgc atgggctcct ctacacggca catcgtgacc     5880

tttgatggcc agaacttcaa gctgaccggc tcctgctctt acgtgctgtt ccagaataag     5940

gagcaggacc tggaagtgat cctgcacaac ggagcatgta gccctggagc aagacagaca     6000

tgcatgaagt ccatcgaggt gaagcacgat ggcctgtccg tggagctgca ctctgacatg     6060

gaggtgaccg tgaatggcag gctggtgagc gtgccatacg tgggcggcaa tatggaggtg     6120

aacatctatg gcgccatcat gcacgagatc cgctttaacc acctgggcca catcttcacc     6180

tttacacccc agaacaatga gtttcagctg cagctgtctc ctaagacctt cgccagcaag     6240

atgtatggcc tgtgcggcat ctgcgatgag aatggcgcca acgatttcat gctgagagac     6300

ggcacagtga ccacagacca gaagacactg atccaggagt ggaccgtgca gcagccagga     6360

cagacctgtc agccagtgcc cgaggagcag tgccctgtga gctcctctag ccactgtcag     6420

gtgctgctgt ccgccctgtt tgcagagtgt cacaaggtgc tggccccagc cacattctac     6480

gccatctgtc agcaggactc ttgccatcgg gagcaggtgt gcgaagtgat cgccagctat     6540

gcccacctgt gcaggaccaa cggcgtgtgc gtggattggc gcaccacaga cttttgcgcc     6600

atgagctgtc ccccttccct ggtgtacaat cactgcgagc acggctgtcc aagacactgc     6660

gagggcaaca cctcctcttg tggcgaccac cccagcgagg gctgcttttg tccaccccac     6720

caggtcatgc tggagggatc ctgcgtgcca gaggaggcat gtacacagtg catctctgag     6780

gatggcgtgc ggcaccagtt cctggagaca tgggtgccag accaccagcc ctgccagatc     6840

tgcatgtgcc tgagcggcag aaaagtgaat tgtacctccc agccttgccc aacagcaagg     6900

gcacctacct gtggaccatg cgaggtggcc agactgcacc agaaccctga ccagtgctgt     6960

ccagagtacg agtgcgtgtg cgatctggtg agctgcgacc tgcctccagt gcctcactgt     7020

gagggaggcc tgcagcccac cctgacaaat cctggcgagt gcaggccaaa cttcacatgc     7080

gcatgtagga aggaggagtg caggagggag agcccacctt cctgtccacc acacaggacc     7140

cctacactgc gcaagaccca gtgctgtgac gagtacgagt gcgcctgtaa ttgcgtgaac     7200

tctacagtga gctgcccact gggatatctg gcctccgccg tgaccaacga ttgtggctgc     7260

accacaacca catgtctgcc agacaaggtg tgcgtgcaca ggggcaccat ctaccccgtg     7320

ggccagtttt gggaggaggg ctgtgacgtg tgcacctgca cagacatgga ggatgccgtg     7380

atgggcctga gggtggcaca gtgcagccag aagccatgtg aggactcctg cagatctggc     7440

ttcacatacg tgctgcacga gggcgagtgc tgtggcaggt gtctgccatc tgcctgcgag     7500

gtggtgaccg gcagccccag gggcgatagc cagtcctatt ggaagagcgt gggctcccac     7560

tgggcctctc ctgagaatcc atgtctgatc aacgaatgcg tgagggtgaa ggaggaggtg     7620

tttgtgcagc agcgcaatgt gagctgccct cagctggacg tgcccacctg tcctgtgggc     7680

ttccagctgt cttgcaagac aagcgagtgc tgtccaacct gtcactgcga gcccgtggag     7740

gcctgtatgc tgaacggcac aatcatcggc cctggcaagt ccctgatgat cgacgtgtgc     7800

accacatgtc actgcaccgt gcaagtgggc gtgatctctg gcttcaagct ggagtgcagg     7860

aagaccacat gtgaggcctg ccctctgggc tacaaggagg agaagaccca gggagagtgc     7920

tgtggccgct gtctgccaac agcatgcacc atccagctga ggggaggaca gatcatgaca     7980

ctgaagagag atgagacact gcaggacggc tgtgatagcc acttttgcaa agtgaatgag     8040

cggggcgagt acatctggga gaagagagtg acaggctgtc ctccattcga cgagcacaag     8100

tgcctggcag agggaggcaa gatcatgaag atccctggca catgctgtga tacctgtgag     8160

gagccagagt gcaaggacat caccgccagg ctgcagtatg tgaaagtggg cgactgcaag     8220

tccgaagagg aggtggatat ccactactgt cagggcaagt gcgccagcaa ggccgtgtat     8280

tccatcgaca cagaggatgt gcaggaccag tgttcttgct gtagcccaac ccgcacagag     8340

cccatgcagg tgcctctgca ctgcaccaat ggcagcgtgg tgtaccacga ggtgctgaac     8400

gccatgcagt gtaagtgctc tcccaggaag tgcagcaag                            8439


<210>  6
<211>  2813
<212>  PRT
<213>  Primate

<400>  6

Met Ile Pro Ala Arg Phe Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Glu Gly Leu Glu Cys Val Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Met Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Ala Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Ile Val Gln Ala Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Lys  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Pro Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  7
<211>  2813
<212>  PRT
<213>  Rodent

<400>  7

Met Asn Pro Ala Arg Phe Glu Ile Trp Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Trp Pro Gly Thr Leu Cys Thr Glu Lys Thr Arg Asp Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Thr Met Tyr Ser Phe Ala Gly Gly Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Leu Gly Asn Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ala Asn Gly Thr Val Met Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Asp Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Met Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


His Cys Asn Ser Ser Ser Gly Asp Met Gln Lys Ala Met Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Thr Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Pro Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Gln Gln Cys Val Asp Gly Cys Gly Cys Pro Glu Gly Glu Leu 
                325                 330                 335     


Leu Asp Glu Asp Arg Cys Val Gln Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Met Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Ser Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Ile Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ser Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu Gln Gly Asp Cys Pro 
545                 550                 555                 560 


Asp Leu His Arg Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Asp Phe Cys Ala Leu Gly Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Asn Ser Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Leu Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Thr Pro Gly Ser Leu Leu Pro Asp Ile Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Gln 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Leu Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Lys Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Gln Glu Tyr Ala Pro Gly Asp Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Arg Trp Asn Cys Thr Asn His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Leu Lys Asp Glu Ser His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Gln Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys His Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Leu Ser 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Gly  Cys Asn Arg Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Gln Val Val Ala Trp  Arg Thr Pro Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Val  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Arg Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Ser  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Asn Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asn Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Leu Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Ile Thr Val Ser Pro  Gly Ile Leu Gly Ile  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Glu Val Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Leu Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Ile Ser Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Asn Glu Ala  Gln Ser Lys Glu Asp  Val Leu Arg 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Gln  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Pro Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Ala Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Phe  Ile Arg Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Arg Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Thr 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Leu Pro Glu Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Asn Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Val Thr Ser Gln Ile  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Ile  Met Asp Thr 
    1790                 1795                 1800             


Ser Leu  Asp Ser Val Asp Thr  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Ala Val Phe Pro Ile  Gly Val Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Gln Val Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Ser Gly Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asn Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  His Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Ser Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Asn Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Ala  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Met Ala Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Ala Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Leu Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Tyr Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe His  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Gln His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Val Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ile Asn  Cys Thr Ala Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Lys 
    2300                 2305                 2310             


Gln Ser  Ala Asn Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Asn Cys Asn Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Thr Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Thr  Cys Thr Cys Thr Asp  Met Glu Asp Thr Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Gln 
    2465                 2470                 2475             


Pro Gly  Phe Ser Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Lys  Val Val Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  His Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Val 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Glu Glu 
    2525                 2530                 2535             


Ala Val  Phe Val Gln Gln Arg  Asn Ile Ser Cys Pro  Gln Leu Ala 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Glu Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Leu 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Leu Cys  Thr Thr Cys Arg Cys  Ile Val Gln Thr Gly  Ala Ile Ser 
    2600                 2605                 2610             


Arg Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Met Gly  Tyr Arg Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Lys  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Glu Gln  Cys Ser Cys Cys Trp  Pro Ser Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Ile Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  8
<211>  2813
<212>  PRT
<213>  Primate/Rodent

<400>  8

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  9
<211>  2812
<212>  PRT
<213>  Ungulate

<400>  9

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Ser Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Val Ser Ser Glu Met Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Met Leu Cys Thr Cys 
                245                 250                 255     


Ala Gln Gly Leu Gln Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser 
        275                 280                 285             


Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val Cys 
305                 310                 315                 320 


Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His Ser 
            340                 345                 350         


Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Leu Trp Val Cys Ser Asn Glu Glu Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Ile Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Pro His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Met Ala Ser Val His Leu Ser Tyr Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Arg Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ala Trp Lys Leu Arg Gly Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Lys Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Arg Phe Ala Glu Glu Ala Cys Ala Ile Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile Ala 
625                 630                 635                 640 


Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln Val 
                645                 650                 655     


Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Pro Gly Leu Tyr Leu Asp Glu Ser Gly Asp Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala 
    850                 855                 860                 


Ser Cys Ser Ala Leu Gly Leu Ala His Tyr Leu Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Gly Tyr Pro Ser Leu Lys Cys Arg Lys Arg Val Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Ser Val Lys Arg 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His 
                965                 970                 975     


Leu Gly Ile Ser Val Phe Leu Lys Gln Thr Tyr Gln Glu Gln Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Gln Cys  Ala Asp Thr Arg Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Ser  Ser Pro Ala Thr Cys  His Asn Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Ile Leu Thr Ser Asp  Ile Phe Gln 
    1055                 1060                 1065             


Asp Cys  Asn Lys Leu Val Asp  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Thr Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Val Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Lys  Val Val Thr Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Arg  Glu Asn Gly Tyr Glu  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asp Pro Glu Asp Cys  Pro Val Cys Glu Val  Ala Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Pro Gly Lys Lys  Ile Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu His  Cys Gln Ile Cys His  Cys Asp Gly Val Asn  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Glu Val Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Ser Pro Thr Thr  Pro Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Val Leu  Lys Ala Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Ile Ala Leu  Arg Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Ser Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Gly Lys  Ile Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Thr Val  Ile Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Ser  Leu Lys Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Pro Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val Asp 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Arg Asp  Glu Ile Ile Ser Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Val Pro Ala  Pro Thr Gln Arg Pro  Leu Val Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Ala Pro Glu  Leu Leu Gly Val Ser  Thr Leu Gly 
    1475                 1480                 1485             


Pro Lys  Arg Ser Ser Met Val  Leu Asp Val Val Phe  Val Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Lys Val Gly Glu  Ala Asn Phe Asn Arg  Ser Thr Glu 
    1505                 1510                 1515             


Phe Val  Glu Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Ser 
    1520                 1525                 1530             


Val His  Val Thr Val Leu Gln  Tyr Ser Tyr Val Val  Thr Val Glu 
    1535                 1540                 1545             


Tyr Ser  Phe Arg Glu Ala Gln  Ser Lys Gly Asp Val  Leu Gln Arg 
    1550                 1555                 1560             


Val Arg  Glu Ile Arg Tyr Gln  Gly Gly Asn Arg Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Asn Pro  Ala Ser Asp Glu Ile  Arg Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Val Val  Pro Ile Gly Val Gly  Pro His Val Asp Val  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Ile Gly Trp Pro Asn  Ala Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Thr  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Gly Glu Gly Pro His  Leu Pro Thr Leu Ser  Pro Ala Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Ser  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Lys Ala  Asn Ile Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Thr Ile  Asp Val Pro 
    1730                 1735                 1740             


Trp Asn  Val Ala Gln Glu Lys  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Leu Met  Gln Arg Glu Gly Gly  Pro Ser Gln Ile Gly  Asp Ala Leu 
    1760                 1765                 1770             


Gly Phe  Ala Val Arg Tyr Val  Thr Ser Glu Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Ala Val  Val Ile Leu Val Thr  Asp Thr Ser 
    1790                 1795                 1800             


Thr Asp  Ser Val Asp Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Arg Tyr  Asp Glu Ala 
    1820                 1825                 1830             


Gln Leu  Arg Thr Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Val 
    1835                 1840                 1845             


Lys Leu  Gln Arg Ile Glu Asp  Leu Pro Thr Met Val  Thr Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Leu His Lys Leu  Cys Ser Gly Phe Val  Arg Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Pro  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Arg 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asn Ser Gln  Ser Pro Ile Arg Val  Glu Glu Thr 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Thr Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Gln Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Ser  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Ile Leu His Asn Gly  Ala Cys Ser Ala Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Ile Glu  Val Lys His Asn Gly  Leu Ser Val 
    2000                 2005                 2010             


Glu Leu  His Ser Asp Met Glu  Val Val Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Val Gly Gly  Asn Met Glu Val Ser  Ile Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Tyr Glu Val Arg  Phe Asn His Leu Gly  His Ile Phe 
    2045                 2050                 2055             


Thr Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Thr  Phe Ala Ser Lys Met  Tyr Gly Leu Cys Gly  Ile Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Arg Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Thr Asp  Trp Lys Thr Leu Val  Gln Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Gln Pro Val  Pro Glu Glu Gln Cys  Pro Val Ser 
    2120                 2125                 2130             


Gly Gly  Ser His Cys Gln Val  Leu Leu Ser Ala Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Leu Ala Pro  Ala Thr Phe His Ala  Ile Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys His Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu His Gly Cys  Pro Arg His Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Ser Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His Gln  Val Met Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Ser Asp Asp  Gly Ile Arg His Gln  Phe Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Ser Gln Pro Cys  Pro Thr Ala 
    2285                 2290                 2295             


Arg Ala  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Asn Ala  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Leu Pro Pro  Val Pro His Cys Glu  Gly Gly Leu 
    2330                 2335                 2340             


Gln Pro  Thr Leu Thr Asn Pro  Gly Glu Cys Arg Pro  Asn Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Pro Arg Gly Pro  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Thr Pro  Ala Leu Arg Lys Thr  Gln Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Glu Cys Ala Cys  Asn Cys Val Asn Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Val Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Glu Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu His  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Tyr Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile Asn  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Thr  Cys Pro Val Gly Phe  Gln Leu Ser Cys Lys  Thr Ser Glu 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Lys Ser Leu Met  Ile Asp Val 
    2585                 2590                 2595             


Cys Thr  Thr Cys Arg Cys Thr  Val Gln Glu Gly Val  Val Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Lys  Thr Thr Cys Glu Ala  Cys Pro Leu 
    2615                 2620                 2625             


Gly Tyr  Lys Glu Glu Lys Met  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Met 
    2645                 2650                 2655             


Thr Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Arg Val Asn Glu Arg  Gly Glu Tyr Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Gly Cys Pro Pro Phe  Asp Glu His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Arg Leu  Gln Tyr Val 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Lys Ser  Glu Glu Glu Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Lys Cys Thr Ser  Lys Ala Val Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Gln Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Glu Val Leu Asn Ala  Met Gln Cys Lys Cys  Ser Pro Arg 
    2795                 2800                 2805             


Lys Cys  Ser Lys 
    2810         


<210>  10
<211>  2813
<212>  PRT
<213>  Early Common Ancestor

<400>  10

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Arg Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Asp Cys Pro Cys Ser Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Thr Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ser Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Gln Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Leu Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Pro Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Leu  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ala Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Thr Arg Ser Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Ile Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Thr Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Ser Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Arg Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Ser  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ser Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Lys Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Gln Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Thr Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  11
<211>  2813
<212>  PRT
<213>  Primate

<400>  11

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Arg Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Val Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Leu Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  12
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  12

Met Ile Met Ile Cys Phe Thr Val Leu Leu Met Gln Leu Ala Leu Pro 
1               5                   10                  15      


Ile Ser Ser Phe Leu Leu Thr Asp Gly Gln Thr Glu Gln Pro Ser Leu 
            20                  25                  30          


Ser Arg Cys Ser Leu Phe Gly Asp Asp His Ile Lys Thr Phe Asp Glu 
        35                  40                  45              


Ser Phe Tyr Asp Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys His Lys Arg Ser Phe Thr Leu Ile Gly Asp Tyr Gln Asn Gly Arg 
65                  70                  75                  80  


Arg Asn Ser Phe Ser Val Tyr Leu Gly Glu Tyr Phe Asp Ile His Leu 
                85                  90                  95      


Ala Leu Asp Gly Thr Val Thr Gln Gly Asp Lys Arg Val Ser Met Pro 
            100                 105                 110         


Phe Ala Ser His Gly Ile Phe Val Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Asp Glu His Gly Phe Val Val Lys Ile Asp Ile Asp Ala 
    130                 135                 140                 


Asn Ile Gln Ile Leu Phe Thr Glu Lys His Tyr Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Lys Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Val Glu Ser Ser Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu His Ser Glu Asp Lys Arg Cys Lys Arg Val Pro Ala Pro Ser Asn 
        195                 200                 205             


Thr Cys Asn Ile Ser Ser Glu Phe Ala Asp Lys Asp Ile Met Glu Arg 
    210                 215                 220                 


Cys Gln Leu Leu Arg Thr Ser Ser Val Phe Ser Lys Cys His His Arg 
225                 230                 235                 240 


Val Asp Pro Glu Val Phe Ile Gly Leu Cys Glu Glu Asp Met Cys Thr 
                245                 250                 255     


Cys Ala Gln Asp Met His Cys Gln Cys Pro Thr Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ser Cys Ala Gln Gln Gly Val Ile Val Asp Gly Trp Pro Asn Asp 
        275                 280                 285             


Ser Ser Cys Arg Pro Arg Cys Pro Val Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Val Lys Thr Cys Gln Ser Leu Asn Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Gly Gln Cys Ala Asp Gly Cys Ser Cys Pro Val Gly Lys Leu 
                325                 330                 335     


Leu Asp Gly Asp Ser Cys Val Asp Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Met Arg Tyr Pro Pro Gly Ser Ser Ile Ser Gln Asp Cys Asn 
        355                 360                 365             


Ser Cys Ile Cys Arg Arg Gly Ile Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Ser Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Lys Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Phe Ala Lys 
                405                 410                 415     


Asp Cys Glu Glu Asn Ser Phe Ser Val Ile Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Ala Ser Val Arg Leu 
        435                 440                 445             


Gln Asp Met Glu Asn Ser Ile Ile Lys Met Lys His Gly Gly Val Ile 
    450                 455                 460                 


Ser Leu Asn Gly Gln Asp Val Gln Ile Pro Leu Thr Gln Gly Ala Leu 
465                 470                 475                 480 


Arg Ile Gln Arg Ile Met Met Ser Ser Val Arg Leu Thr Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Ile Asp Trp Asp Gly Arg Gly Lys Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Met Tyr Thr Asp Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Glu Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Ala 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu Asn Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Leu Lys Gln Asp Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Ala Lys Tyr Ala Glu Asp Ser Cys Ser Ile Leu Met Ser Ser Met Phe 
            580                 585                 590         


Glu Pro Cys His His Glu Val Ser Pro Pro Pro Tyr Leu Lys Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Lys Asp Cys Leu Cys Ala 
    610                 615                 620                 


Ala Val Ser Thr Tyr Ala Thr Ala Cys Ala Arg Lys Gly Val Leu Ile 
625                 630                 635                 640 


Glu Trp Arg Glu Pro Asp Phe Cys Ser Met Thr Cys Pro Glu Gly Gln 
                645                 650                 655     


Ile Tyr Gln Gln Cys Gly Thr Pro Cys Asn Gln Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Val Gly Cys Asn Glu Phe Cys Met Glu Gly Cys Tyr 
        675                 680                 685             


Cys Pro His Gly Gln Tyr Ile Asp Glu His Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ser Gln Cys Ser Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Asp Asp 
705                 710                 715                 720 


Val Phe Ser Asp His Tyr Thr Met Cys Tyr Cys Glu Asn Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Asn Lys Leu Pro Gly Ala Phe Leu Pro Asp Val Phe 
            740                 745                 750         


Phe Asp Asn Gln Pro Ser Ala Arg Ile Lys Arg Ser Leu Thr Cys Arg 
        755                 760                 765             


Ala Pro Met Asp Lys Phe Val Cys Pro Pro Asn Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Ile Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val 
785                 790                 795                 800 


Ser His Gly Cys Ile Ser Gly Cys Leu Cys Pro Lys Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Lys Cys Val Val Pro Glu Arg Cys Pro Cys Phe His Asn 
            820                 825                 830         


Gly Arg Glu Tyr Ala Lys Gly Glu Thr Val Asn Lys Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Gly Arg Lys Trp Asp Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Thr Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Asp Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Ala Asp Glu Pro Gly Thr Phe Arg Val Leu Ile Ser Asn Glu 
            900                 905                 910         


Gly Cys Gly Phe Thr Gly Glu Lys Cys Thr Lys Arg Ile Thr Ile Leu 
        915                 920                 925             


Phe Asp Asn Gly Glu Ile Glu Leu Phe Asn Gly Asn Val Asp Ile Lys 
    930                 935                 940                 


Lys Pro Leu Arg Asp Glu Thr Asn Phe Glu Val Leu Lys Ser Gly Arg 
945                 950                 955                 960 


Tyr Tyr Ile Leu Leu Leu Gly Lys Gly Ile Ser Val Thr Trp Asp Leu 
                965                 970                 975     


Ala Met Gly Val Ser Val Ile Leu Lys Glu His Phe Lys Asp Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Ser Lys His Leu Glu  Val Asp Pro Ile Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gly  Cys Ala Asp Val Arg  Lys Leu Pro 
    1025                 1030                 1035             


Gln Gly  Gln Thr Met Thr Thr  Cys Asn Asp Asn Val  Met Lys Gln 
    1040                 1045                 1050             


Met Met  Val Glu Thr Ser Cys  Ser Ile Leu Thr Ser  Glu Ile Phe 
    1055                 1060                 1065             


Lys Glu  Cys Lys Lys Leu Val  Asn Pro Glu Pro Tyr  Met Asp Ile 
    1070                 1075                 1080             


Cys Met  Tyr Asp Thr Cys Ala  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Ala Ile Ala  Ala Tyr Ala His Ile  Cys Ala Gln 
    1100                 1105                 1110             


Lys Gly  Ala Val Val His Trp  Arg Ser Pro Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Asp Leu Asn Lys  His Glu Leu Glu Tyr  Gln Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Gly  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Phe  Glu Pro Val Ala Cys  Pro Leu Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Val  His Cys Pro Glu Gly  Lys Ile Leu Asp Glu  Leu Ser Gln 
    1175                 1180                 1185             


Ser Cys  Ile Asp Pro Glu Asp  Cys Pro Val Cys Ile  Leu Glu Gly 
    1190                 1195                 1200             


Ala Arg  Ile Pro His Gly Lys  Arg Val Val Leu Asn  Lys Asp Asp 
    1205                 1210                 1215             


Asp Glu  His Cys Arg Ser Cys  His Cys Glu Gly Lys  Asn Leu Thr 
    1220                 1225                 1230             


Cys Ser  Ala Cys Glu Ser Lys  Glu Asp Leu Gln Leu  Pro Lys Lys 
    1235                 1240                 1245             


Glu Glu  Ile Ile Thr Pro Thr  Pro Ala Ser Thr Glu  Glu Thr Asp 
    1250                 1255                 1260             


Asp Thr  Gly Thr His Val Tyr  Ser Cys Ser Lys Met  Met Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Met Asp Gly Ser  Asn Lys Leu Ser Glu  Lys Asp Phe 
    1280                 1285                 1290             


Glu Leu  Leu Lys Ala Phe Ile  Ile Ser Met Met Glu  Lys Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Lys Ile Arg  Val Ser Ile Leu Glu  Tyr Arg Thr 
    1310                 1315                 1320             


Gly Ser  Asn Ile Tyr Leu Gly  Leu Lys Asp Ile Lys  Thr Gln Ser 
    1325                 1330                 1335             


Gln Met  Arg Lys Ile Val Gln  Asn Ile Lys Tyr Thr  Gly Gly Glu 
    1340                 1345                 1350             


Val Ala  Ser Ala Thr Glu Val  Leu Lys Tyr Ile Val  Phe His Val 
    1355                 1360                 1365             


Phe Gly  Lys Ala Pro Arg Thr  Asn Ala Ala Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Lys Ser Pro  Pro Pro Thr Ala Arg  Asn Ile Gln 
    1385                 1390                 1395             


Arg Ile  Leu Pro Leu Leu Lys  Lys Lys Lys Val Thr  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro Ser Ile  Ser Met Glu Gln Ile  Lys Leu Ile 
    1415                 1420                 1425             


Glu Arg  Gln Trp Pro Glu Asn  Lys Ala Phe Ile Met  Asn Asn Val 
    1430                 1435                 1440             


Gln Glu  Leu Met Glu Asn Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Val Pro Glu Thr Gln  Lys Pro Thr Val Pro  Pro Gln Ala 
    1460                 1465                 1470             


Ala Lys  Val Thr Val Gly Ser  Glu Thr Arg Leu Ala  Thr Thr Pro 
    1475                 1480                 1485             


Leu Pro  Ser Ala Val Ser Lys  Val Leu Asp Ile Ala  Phe Val Val 
    1490                 1495                 1500             


Glu Gly  Ser Glu Lys Val Gly  Glu Glu Asn Phe Asn  Ile Ile Lys 
    1505                 1510                 1515             


Glu Phe  Ile Ala Lys Val Ile  Arg Glu Met Asp Ile  Gly Glu Glu 
    1520                 1525                 1530             


Thr Ile  His Ile Thr Ile Ile  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Ser Phe Ser Glu Ala  Gln Ser Lys Gln Asp  Ile Ile Glu 
    1550                 1555                 1560             


Val Val  Arg Lys Ile Gln Tyr  Gln Gly Gly Asn Ala  Thr Asn Thr 
    1565                 1570                 1575             


Gly Asn  Ala Leu Ser Tyr Val  Ser Glu His Thr Phe  Thr Thr Asp 
    1580                 1585                 1590             


Lys Gly  Gly Arg Gly Gln Val  Pro His Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Ala Asn  Pro Ala Thr Asp Val  Ile Ser Arg Val Ala  Gly Asp Ile 
    1610                 1615                 1620             


Asn Val  Ile Pro Ile Gly Ile  Thr Pro Asn Ala Asn  Ile Gln Glu 
    1625                 1630                 1635             


Leu Glu  Met Ile Ser Gln Arg  His Thr Pro Ile Ile  Ile Asn Gly 
    1640                 1645                 1650             


Tyr Asp  Lys Leu Ile Arg Glu  Ala Pro Asp Leu Val  Leu Lys Thr 
    1655                 1660                 1665             


Cys Cys  Ser Asn Lys Ser Ser  Met Leu Pro Ser Leu  Pro Pro Ser 
    1670                 1675                 1680             


Pro Leu  Cys Ser Arg Pro Met  Asp Ile Met Phe Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Gly Ala Ser  Glu Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Val Lys  Ala Phe Ile Glu Asn  Tyr Gly Ile Ser Asn  Thr Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Ala Arg Ala Asn Thr  Leu Glu Ile 
    1730                 1735                 1740             


Ser Trp  Asn Met Pro Gln Glu  Ser Glu Asn Leu Leu  Asn Arg Val 
    1745                 1750                 1755             


Ser Ile  Gln Gln Arg Glu Gln  Gly Pro Ser Lys Leu  Gly Glu Ala 
    1760                 1765                 1770             


Val Asn  Phe Ala Val Gln His  Ala Met Ser Glu Ala  His Gly Gly 
    1775                 1780                 1785             


Arg Pro  Asn Ala Ser Lys Ile  Ala Val Ile Ile Val  Ser Glu Lys 
    1790                 1795                 1800             


Ser Glu  Asp Pro Val Asp Ser  Ala Ala Tyr Ser Ala  Ser Ile Asn 
    1805                 1810                 1815             


Arg Val  Ser Leu Phe Pro Ile  Gly Val Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Glu Gln  Leu Arg Thr Leu Ala  Gly Gln Ser Ala Ala  Asp Lys Ile 
    1835                 1840                 1845             


Met Lys  Leu Arg Arg Phe Glu  Asp Leu Pro Glu Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asp  Ala Phe Val Asn Lys  Leu Cys Thr Glu Pro  Thr Arg Glu 
    1865                 1870                 1875             


Cys Ile  Asp Glu Asp Gly Asn  Lys Arg Arg Pro Gly  Asp Lys Trp 
    1880                 1885                 1890             


Thr Leu  Thr Asp Lys Cys His  Ser Val Thr Cys Leu  Pro Gly Gly 
    1895                 1900                 1905             


Gln Thr  Val Leu Glu Ser His  Arg Ile Asn Cys Glu  Lys Met Pro 
    1910                 1915                 1920             


Lys Pro  Thr Cys His Asn Asn  Leu Pro Ala Val Lys  Thr Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Met Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Leu Asp  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Asn Cys Ser Tyr Thr  Leu Phe Gln Asp Lys  Glu His Asp 
    1970                 1975                 1980             


Ile Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Ser  Thr Pro Lys 
    1985                 1990                 1995             


Leu Asn  Cys Met Asn Ala Ile  Glu Val Lys His His  Gly Lys Ser 
    2000                 2005                 2010             


Ile Gln  Leu Ser Ser Asp Met  Thr Val Ala Val Asn  Gly Glu Met 
    2015                 2020                 2025             


Thr Ala  Val Pro Tyr Ile Asp  Asp Tyr Phe Glu Val  Thr Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Ser Gln Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Arg Asn  Asn Glu Phe Thr Leu  His Leu Asp 
    2060                 2065                 2070             


Pro Arg  Ser Phe Ser Ser Gln  Thr Tyr Gly Leu Cys  Gly Val Cys 
    2075                 2080                 2085             


Asp Gln  Asn Asn Gly Asn Asp  Phe Met Leu Ser Asn  Gly Ser Val 
    2090                 2095                 2100             


Thr Ser  Asp Ser Ser Thr Phe  Ile Gln Glu Trp Thr  Val Lys Glu 
    2105                 2110                 2115             


Pro Gly  Lys Ile Cys Glu Ile  Lys Arg Asp Asp Arg  Cys Thr Glu 
    2120                 2125                 2130             


His Ala  Thr Thr Lys Cys Asn  Val Leu Arg Ser Pro  Gln Phe Ala 
    2135                 2140                 2145             


Gln Cys  His Arg Ile Ile Ser  Pro Asp Ser Phe Tyr  Ser Ala Cys 
    2150                 2155                 2160             


Glu Glu  Asn Ser Cys Tyr Glu  Asp Glu Ile Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Val Cys Arg  Thr Asn Gly Val Cys  Val Ile Trp 
    2180                 2185                 2190             


Arg Ser  Pro Glu Phe Cys Ala  Met Lys Cys Pro Gly  Ser Leu Ile 
    2195                 2200                 2205             


Tyr Asp  His Cys Arg Thr Ser  Cys Thr Lys His Cys  Glu Ser Thr 
    2210                 2215                 2220             


Ile Ser  Val Cys Lys Asp Tyr  Pro Thr Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Gly  Gln Val Thr Leu Asn  Ser Asn Cys Val Asp  Glu Glu Val 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ala Glu  Asp Gly Thr His His  Gln His Met 
    2255                 2260                 2265             


Glu Thr  Trp Ile Pro Phe Asn  Glu Pro Cys Lys Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Glu  Asn Arg Ile Ile Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Pro Ala Val Cys Gly  Pro Cys Glu Val Ser  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asp  Ser Asp Gln Cys Cys  Pro Lys Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Thr Cys Asp Leu Pro  Ala Val Pro Ala Cys  Glu Asp Gly 
    2330                 2335                 2340             


Leu Gln  Pro Val Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Thr Tyr 
    2345                 2350                 2355             


Thr Cys  Ala Cys Lys Gln Glu  Glu Cys Lys Arg Glu  His Val Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Glu  Leu Thr Val Lys Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Thr  Cys Ser Cys Thr Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Ala Gly Tyr Leu  Ser Thr Ser Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Ile Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Asn  Val Val Tyr Pro Ile  Gly Lys Ser Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Thr Asp  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Leu Gly Leu 
    2450                 2455                 2460             


His Ile  Ala Glu Cys Leu Glu  Lys Glu Cys Ser Thr  Ile Cys Pro 
    2465                 2470                 2475             


Gln Gly  Tyr Thr Tyr Val Ser  Gln Glu Gly Glu Cys  Cys Gly Lys 
    2480                 2485                 2490             


Cys Gln  Lys Thr Met Cys Glu  Glu Gln Asn Ser Trp  Ser Arg Gly 
    2495                 2500                 2505             


Asp Val  Asp Val Arg Leu His  Glu Val Gly Thr Glu  Trp Arg Ser 
    2510                 2515                 2520             


Pro Phe  Ser Pro Cys Ile Ile  Asn Lys Cys Val Arg  Val Asn Asp 
    2525                 2530                 2535             


Glu Val  Phe Val Glu Lys Arg  Asn Val Ser Cys Ser  Gln Met Asp 
    2540                 2545                 2550             


Thr Pro  Thr Cys His Leu Gly  Tyr Glu Leu Arg Cys  Arg Ile Thr 
    2555                 2560                 2565             


Asn Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Asn  Gly Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Val Gly  Val Gly Glu His Leu  Met Leu Asp 
    2585                 2590                 2595             


Gln Cys  Thr Asn Cys Gln Cys  Ser Leu Gln Arg Gly  Leu Pro Leu 
    2600                 2605                 2610             


Asn Tyr  Lys Leu Thr Cys Arg  Lys Thr Thr Cys Glu  Pro Cys Pro 
    2615                 2620                 2625             


Lys Asn  Tyr Arg Met Glu Glu  Ile Ser Gly Ser Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Val  Pro Thr Ser Cys Gly  Ile Lys Leu Arg Asp  Gly Arg Ile 
    2645                 2650                 2655             


Leu Tyr  Leu Lys Pro Asn Glu  Thr Ile Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Ser  Cys Lys Val Asn Glu  Lys Arg Glu Phe Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Ile  Thr Gly Cys Pro Pro  Phe Asp Ser Arg Arg  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Ala Lys  Ile Asp Asn Thr Cys  Cys Glu Thr 
    2705                 2710                 2715             


Cys Ile  Glu Ala Glu Cys Arg  Gln Val Ser Ser Arg  Leu Thr Tyr 
    2720                 2725                 2730             


Leu Asn  Ile Asn Gly Cys Glu  Ala Glu Asp Gly Val  Ser Ile Phe 
    2735                 2740                 2745             


Gln Cys  Glu Gly Lys Cys Arg  Ser Lys Thr Lys Tyr  Ser Ile Glu 
    2750                 2755                 2760             


Met Asn  Arg Leu Glu Asp Glu  Cys Thr Cys Cys Ser  Ala Thr Gln 
    2765                 2770                 2775             


Thr Val  Pro Val Asn Val Pro  Leu Arg Cys Ala Asn  Gly Thr Val 
    2780                 2785                 2790             


Val Gln  His Glu Val Pro Ser  Ala Val Gln Cys Glu  Cys Phe Ser 
    2795                 2800                 2805             


Arg Lys  Cys Thr Thr 
    2810             


<210>  13
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  13

Met Ile Cys Leu Arg Leu Thr Cys Ile Leu Leu Ala Leu Ala Leu Pro 
1               5                   10                  15      


Leu Ala Ser Thr Leu Leu Thr Glu Gly Lys Lys Gly Gln Ser Ser Met 
            20                  25                  30          


Ser Arg Cys Ser Leu Phe Gly Asp Asp His Ile Lys Thr Phe Asp Glu 
        35                  40                  45              


Ser Phe Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Lys Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ile Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Lys Ile Asp Ala Asp Gly 
    130                 135                 140                 


Asn Phe Gln Ile Leu Leu Ser Glu Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Lys Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Arg Ser Ala Glu Gln Arg Cys Lys Arg Val Ser Pro Pro Ser Asn 
        195                 200                 205             


Thr Cys Asn Ile Ser Ser Val Glu Met Glu Lys Gly Leu Gln Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ser Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Ile Ala Leu Cys Glu Lys Asp Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Glu Gln Asp Cys Ala Cys Ser Thr Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ser Cys Ala Gln Gln Gly Met Val Leu Asn Gly Trp Thr Asn Asp 
        275                 280                 285             


Ser Thr Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Asn Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Lys Leu 
                325                 330                 335     


Leu Asp Asn Gly Arg Cys Val Glu Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ser Ser Ile Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Lys Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Leu Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Val Val 
    450                 455                 460                 


Ser Leu Asp Gly Gln Asp Val Gln Ile Pro Leu Met Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln Arg Thr Val Met Ala Ser Val Arg Leu Thr Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Ile Asp Trp Asp Gly Arg Gly Lys Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu Asn Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Leu Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Lys Tyr Ala Glu Glu Ser Cys Ser Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Pro Cys His His Ala Val Ser Pro Thr Pro Tyr Leu Lys Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Lys Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Val Leu Ile 
625                 630                 635                 640 


Glu Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Glu Gly Gln 
                645                 650                 655     


Val Tyr Gln Gln Cys Gly Thr Pro Cys Asn Gln Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Met Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Ile Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Asn Gly Leu Pro Gly Ser Leu Leu Pro Asp Val Ile 
            740                 745                 750         


Leu Asp Ser His Pro Ser Ala Arg Ile Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Phe Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Ile Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val 
785                 790                 795                 800 


Ser His Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Lys 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asn Arg Lys Trp Asp Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Asn Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Phe Ser Ser Val Lys Cys Ser Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Phe Glu Asp Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Leu Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Tyr Ile Leu Leu Leu Gly Lys Gly Ile Ser Val Val Trp Asp Arg 
                965                 970                 975     


Asn Met Gly Ile Ser Val Ile Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Leu Glu  Met Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Arg Glu  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Ala Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Thr Val Val Asn Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Arg  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Val  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Pro Glu Asp  Cys Pro Val Cys Glu  Leu Glu Gly 
    1190                 1195                 1200             


Arg Arg  Leu Pro Gln Gly Lys  Arg Val Val Leu Asn  Lys Asp Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Lys Leu Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Lys Pro  Gly Asp Leu Gln Leu  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Thr Val Ser Pro Thr  Thr Ala Tyr Val Glu  Glu Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Ser Phe  Tyr Cys Ser Lys Met  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Ser Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe His Ile 
    1355                 1360                 1365             


Phe Gly  Lys Val Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Pro Thr Ala Arg  Asn Ile Ala 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asn Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Val Pro Glu Ser Pro  Ala Pro Thr Leu Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu Leu Leu Ala Val  Ser Pro Pro 
    1475                 1480                 1485             


Leu Pro  Ser Ser Ser Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Gln Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Ile Thr Ile Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Ser Phe Ser Glu Ala  Gln Ser Lys Arg Asp  Ile Leu Glu 
    1550                 1555                 1560             


Arg Val  Arg Gln Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Lys  Ala Leu Gln Tyr Leu  Ser Glu His Thr Phe  Ser Thr Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro His Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Thr Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Ile Gln Glu 
    1625                 1630                 1635             


Leu Glu  Met Ile Ser Arg Pro  Asn Ala Pro Ile Leu  Ile Asn Asp 
    1640                 1645                 1650             


Phe Glu  Arg Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Arg Leu Pro Thr Leu  Pro Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Ile Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Ser  His Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Lys Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Ile 
    1730                 1735                 1740             


Pro Trp  Asn Val Pro Gln Glu  Lys Glu His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Asn  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Asp Ala Ser Lys Val  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ser  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Ser Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ser Gln  Leu Arg Thr Leu Ala  Gly Pro Ala Ala Ser  Ser Asn Ile 
    1835                 1840                 1845             


Met Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asn  Ser Phe Met His Lys  Leu Cys Ser Gly Phe  Ser Arg Val 
    1865                 1870                 1875             


Cys Leu  Asp Glu Asp Gly Asn  Lys Lys Arg Pro Gly  Asp Arg Trp 
    1880                 1885                 1890             


Thr Leu  Ala Asp Lys Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Ile Leu Glu Ser His  Arg Val Asn Cys Glu  Lys Gly Pro 
    1910                 1915                 1920             


Lys Pro  Thr Cys Pro Asn Ser  Gln Pro Ala Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asp  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Lys 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His His  Gly Leu Ser 
    2000                 2005                 2010             


Val Gln  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Asp  Glu Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Ser His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp His Asn Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Glu Pro  Val Ala Glu Glu Gln  Cys Pro Asp 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ser  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Arg Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asn Ser Cys His Glu  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asn Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Lys Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Gln Gln Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Thr Cys Val Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Gly  Gln Val Met Leu Glu  Gly Lys Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val His His  Gln Tyr Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Phe Asn  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Asn  Asn Arg Lys Ile Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ser Thr Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Asp Gly 
    2330                 2335                 2340             


Leu Gln  Pro Val Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Tyr 
    2345                 2350                 2355             


Thr Cys  Ala Cys Lys Lys Glu  Glu Cys Arg Arg Glu  Pro Ile Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Leu Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ser Ser Ser Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Ile Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Val Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Lys Thr  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


His Val  Ala Glu Cys Ser Glu  Lys Pro Cys Glu Glu  Ser Cys Gln 
    2465                 2470                 2475             


Gln Gly  Phe Thr Tyr Val Ser  Gln Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Glu Asn Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Glu Ile His Trp Gln  Ser Val Gly Ser Gln  Trp Arg Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Leu Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys His  Cys Glu Pro Val Gln  Gly Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys His Leu  Met Ile Asp 
    2585                 2590                 2595             


Gln Cys  Thr Thr Cys His Cys  Ser Val Gln Ser Gly  Ile Ile Leu 
    2600                 2605                 2610             


Lys Tyr  Lys Leu Val Cys Arg  Lys Thr Thr Cys Glu  Pro Cys Pro 
    2615                 2620                 2625             


Gln Gly  Tyr Lys Glu Glu Lys  Val Glu Gly Ser Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Arg Ile 
    2645                 2650                 2655             


Met Ala  Leu Lys Ala Asn Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Tyr  Cys Lys Val Asn Glu  Lys Gly Glu Phe Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Gln Gln Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Val Lys  Ile Gln Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Ile  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Ile Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asn Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Pro  Ser Lys Ala Ile Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Gln  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Gln 
    2765                 2770                 2775             


Thr Glu  Pro Val Gln Val Pro  Leu Gln Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Leu Gln Cys Gln  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Thr Thr 
    2810             


<210>  14
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  14

Met Thr Cys Leu Lys Leu Thr Cys Ile Pro Leu Ala Leu Ala Leu Pro 
1               5                   10                  15      


Leu Ala Leu Gly Leu Leu Thr Ser Gly Lys Lys Gly Gln Lys Ser Val 
            20                  25                  30          


Ser Arg Cys Ser Leu Phe Gly Asp Asp His Ile Lys Thr Phe Asp Asp 
        35                  40                  45              


Arg Phe Tyr Ser Phe Gly Gly Asp Cys Ser Tyr Leu Leu Thr Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Glu Asn Gly Lys 
65                  70                  75                  80  


Arg Lys Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ile Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Ile Ser Ile Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Met Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Val Tyr Gly Phe Val Ala Lys Ile Asp Ala Asp Gly 
    130                 135                 140                 


Asn Phe Gln Ile Leu Leu Pro Glu Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Asp Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asn Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Arg Ser Ala Glu Arg Arg Cys Lys Arg Val Ser Leu Pro Ser Asp 
        195                 200                 205             


Thr Cys Asn Ile Ser Ser Val Glu Met Glu Lys Gly Leu Gln Glu Gln 
    210                 215                 220                 


Cys Gln Ile Leu Lys Ser Ser Ser Val Phe Ala Gln Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Ile Ala Leu Cys Glu Lys Asp Leu Cys His 
                245                 250                 255     


Cys Ala Gln Glu Gln Gly Cys Ala Cys Ser Ile Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Asn Cys Ala Gln Arg Gly Met Val Leu Asn Asp Trp Thr His Asp 
        275                 280                 285             


Ser Lys Cys Arg Pro Ala Cys Pro Thr Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Asn Gln Cys Ile Asp Gly Cys Ser Cys Pro Glu Gly Lys Leu 
                325                 330                 335     


Leu Asp Asn Gly Leu Cys Val Glu Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys His Tyr Pro Pro Gly Ser Ser Ile Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Lys Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asn Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Leu Arg Leu 
        435                 440                 445             


Leu Pro Leu His Asn Ser Met Val Lys Leu Lys His Gly Gly Val Val 
    450                 455                 460                 


Ser Leu Asp Gly Gln Asp Ile Gln Ile Pro Leu Met Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln Arg Thr Val Met Ala Ser Val Arg Leu Thr Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Ile Asp Trp Asp Gly Ser Gly Lys Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu Asn Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Leu Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Lys Tyr Ala Glu Glu Ser Cys Ser Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Pro Cys His Pro Val Ile Ser Pro Thr Pro Tyr Leu Lys Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Lys Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Ile Leu Ile 
625                 630                 635                 640 


Glu Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Glu Gly Gln 
                645                 650                 655     


Val Tyr Gln Gln Cys Gly Thr Pro Cys Asn Gln Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Met Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Thr Asp Glu Lys Arg Asn Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Thr Asn Gly Leu Pro Gly Gly Leu Leu Pro Asp Val Ile 
            740                 745                 750         


Leu Asp Ser His Pro Ser Ala Arg Ile Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Phe Val Cys Pro Val Asp Asn Pro Gln Ala Glu 
    770                 775                 780                 


Gly Ile Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val 
785                 790                 795                 800 


Ser His Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Gly Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Lys 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asn Arg Arg Trp Asp Cys Thr Asp Thr Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Thr Phe Pro Gly Lys Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


His Cys Gly Asn Asn Pro Gly Thr Phe Arg Ile Leu Val Glu Asn Glu 
            900                 905                 910         


Asp Cys Ser Phe Ser Ser Val Lys Cys Ser Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Phe Glu Asp Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Leu Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Tyr Ile Leu Leu Leu Gly Lys Gly Ile Ser Leu Ile Trp Asp Arg 
                965                 970                 975     


Asn Met Gly Ile Ser Val Ile Leu Lys Gln Thr Tyr Gln Glu Arg Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Asn Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Leu Glu  Met Gly Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Ser  Glu Val Leu 
    1025                 1030                 1035             


Leu Asp  Asp Ala Pro Ala Thr  Cys Gln Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Thr Phe 
    1055                 1060                 1065             


Arg Glu  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Ala Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Thr Val Val Asn Trp  Arg Thr Asp Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Lys Asn Arg  Arg Glu Asn Gly His  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Ser Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ser Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ile  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Pro Thr Asp  Cys Pro Val Cys Glu  Leu Glu Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ser Gln Gly Lys  Arg Ile Phe Leu Asn  Lys Asp Asp 
    1205                 1210                 1215             


Pro Lys  Leu Cys Lys Leu Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Lys Pro  Gly Asp Leu Gln Leu  Pro Pro Ser 
    1235                 1240                 1245             


Phe Thr  Thr Val Ala Pro Thr  Thr Ala Tyr Leu Glu  Glu Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Ser Phe  Tyr Cys Ser Lys Met  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Val Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Arg Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Ser Val Arg Tyr Ala  Gly Ser Lys 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe His Ile 
    1355                 1360                 1365             


Phe Gly  Lys Val Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Pro Thr Ala Arg  Ser Ile Ala 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Leu Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Leu Leu  Ser Gly Val 
    1430                 1435                 1440             


Asn Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Leu Gly  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Val Pro Asp Ser Pro  Ala Pro Thr Leu Pro  Ser Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Ala Ser Pro  Glu Leu Leu Ala Thr  Ser Pro Pro 
    1475                 1480                 1485             


Leu His  Ser Ser Ser Gln Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Gln Val Ile  Gln Arg Met Asp Val  Ser Gln Gly 
    1520                 1525                 1530             


Ser Ile  His Ile Ser Ile Leu  Gln Tyr Ser Tyr Thr  Val Ser Val 
    1535                 1540                 1545             


Glu Phe  Ser Phe Asn Glu Thr  Gln Ser Lys Arg His  Ile Leu Glu 
    1550                 1555                 1560             


Arg Val  Lys Gln Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Lys  Ala Leu Gln Tyr Leu  Ser Glu Asn Thr Phe  Ser Ser Ser 
    1580                 1585                 1590             


Gln Gly  Thr Arg Lys Gln Ala  Pro His Leu Val Tyr  Met Val Val 
    1595                 1600                 1605             


Gly Asn  Pro Ala Thr Asp Glu  Ile Lys Arg Leu Pro  Gln Asp Ile 
    1610                 1615                 1620             


Gln Leu  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Ile His Glu 
    1625                 1630                 1635             


Leu Glu  Met Leu Ser Arg Pro  Asn Ala Pro Ile Leu  Ile Asn Asp 
    1640                 1645                 1650             


Phe Glu  Arg Leu Pro Trp Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Arg Leu Pro Thr Leu  Pro Pro Ala 
    1670                 1675                 1680             


Leu Asp  Cys Thr Gln Pro Leu  Asp Ile Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Ser  His Phe Glu Glu Met  Lys Asn Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Lys Lys  Ala Asn Leu Gly Pro  Arg Val Thr 
    1715                 1720                 1725             


Gln Ile  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Ile 
    1730                 1735                 1740             


Pro Trp  Asn Val Pro Gln Glu  Lys Glu Tyr Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Pro  Met Gln Leu Glu Gly  Gly Pro Ser Gln Ile  Gly Asn Ala 
    1760                 1765                 1770             


Leu Asn  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Asp Ala Ser Lys Val  Ile Val Ile Leu Val  Thr Ala Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ser  Ala Ala Asp Ala Ala  Arg Ser Ser 
    1805                 1810                 1815             


Arg Val  Ser Val Phe Pro Ile  Ala Ile Gly His Gln  Tyr Asp Glu 
    1820                 1825                 1830             


Ser Gln  Ile Arg Thr Leu Ala  Gly Ser Ala Ser Ser  Ser Asn Ile 
    1835                 1840                 1845             


Met Lys  Leu Gln Arg Ile Glu  Asp Leu Ser Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asn  Thr Phe Met Tyr Lys  Leu Cys Ser Gly Phe  Ser Lys Val 
    1865                 1870                 1875             


Cys Leu  Asp Glu Asp Gly Asn  Lys Lys Arg Pro Gly  Asp Arg Trp 
    1880                 1885                 1890             


Thr Leu  Ala Asp Lys Cys His  Thr Val Thr Cys Leu  Ser Asp Gly 
    1895                 1900                 1905             


Gln Thr  Ile Met Glu Ser His  Arg Val Asn Cys Glu  Lys Gly Pro 
    1910                 1915                 1920             


Lys Pro  Thr Cys Pro Asn Ser  Gln Pro Ala Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asp  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Asn Ser Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Ile Asn Leu His Asn  Gly Ala Cys Asn Pro  Gly Met Lys 
    1985                 1990                 1995             


Ala Thr  Cys Met Lys Ser Ile  Glu Val Lys His Lys  Gly Leu Ser 
    2000                 2005                 2010             


Val Gln  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Asp  Glu Asn Met Glu Val  Asn Thr Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Ser His Leu  Asn His Val 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp His Asn Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Thr Thr Cys Glu Pro  Val Ala Glu Glu Gln  Cys Leu Asp 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Ile Leu Leu Ser Ser  Val Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Arg Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asn Ser Cys His Glu  Glu Gln Val Cys Glu  Val Ile Ser 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr His Gly Val Cys  Val Asn Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Lys Cys Pro Pro  Ser Met Val 
    2195                 2200                 2205             


Tyr His  His Cys Gln Gln Asp  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Ser Ser  Thr Cys Val Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Gly  Gln Val Met Leu Glu  Gly Lys Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val His His  Glu Tyr Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Phe Gly  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Asn  Asn Arg Lys Ile Asn  Cys Thr Ser Gln Pro  Cys His Thr 
    2285                 2290                 2295             


Ala Arg  Ser Thr Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Gly  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Asp Gly 
    2330                 2335                 2340             


Leu Gln  Pro Val Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Tyr 
    2345                 2350                 2355             


Ile Cys  Ala Cys Lys Lys Glu  Glu Cys Arg Asn Glu  Pro Ile Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Leu Thr Pro Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Thr  Glu Tyr Glu Cys Ala  Cys Ser Cys Phe Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ser Ser Ser Ile Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Ile Ser Thr Thr Cys  Ile Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


His Gly  Thr Val Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Lys Thr  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Val Gly Leu 
    2450                 2455                 2460             


His Val  Ala Glu Cys Ser Asp  Lys Pro Cys Glu Glu  Ser Cys Gln 
    2465                 2470                 2475             


Gln Gly  Phe Thr Tyr Val Ser  Gln Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Glu Gly Gly Ser  His Arg Gly 
    2495                 2500                 2505             


Asp Ser  Glu Ile His Trp Gln  Ser Val Gly Ser Gln  Trp Arg Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Gln Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Leu Gly  Phe Gln Leu Ser Cys  Gln Ala Ala 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys His  Cys Glu Pro Val Gln  Gly Cys Met 
    2570                 2575                 2580             


Ile Asn  Asp Thr Ile Ile Gly  Pro Gly Asn His Leu  Met Val Asp 
    2585                 2590                 2595             


Gln Cys  Thr Thr Cys His Cys  Ser Val Gln Ser Gly  Ile Ile Leu 
    2600                 2605                 2610             


Lys Tyr  Lys Leu Val Cys Gly  Lys Thr Thr Cys Gln  Pro Cys Pro 
    2615                 2620                 2625             


Gln Gly  Tyr Lys Glu Glu Lys  Val Glu Gly Ser Cys  Cys Gly Lys 
    2630                 2635                 2640             


Cys Leu  Pro Val Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Arg Ile 
    2645                 2650                 2655             


Met Ala  Leu Lys Ala Asn Glu  Thr Phe Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Tyr  Cys Arg Ile Ser Glu  Lys Gly Glu Phe Ile  Trp Glu Arg 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asn Gln Gln Lys  Cys Leu Ala 
    2690                 2695                 2700             


Asp Gly  Gly Lys Ile Val Lys  Ile Gln Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Ile  Glu Arg Glu Cys Lys  Asp Ile Thr Ala Lys  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Ile Gly Ser Cys Lys  Ser Glu Val Glu Val  Asn Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Pro  Ser Lys Ala Ile Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ala Gln  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Gln 
    2765                 2770                 2775             


Ile Glu  Pro Val Arg Val Pro  Leu Gln Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Asp Ile Phe Asn  Ala Leu Lys Cys Gln  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Thr Thr 
    2810             


<210>  15
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  15

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Glu Cys Pro Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  16
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  16

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu Leu Leu Gly Val  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  17
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  17

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu Leu Leu Gly Val  Ser Ser Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Ile Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  18
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  18

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu Arg Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu Leu Leu Gly Val  Ser Ser Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Gly Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Ile Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Met Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Ile Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  19
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  19

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Val Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Val Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Arg Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu Arg Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Val  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Ala Pro  Glu Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Arg 
    1505                 1510                 1515             


Glu Phe  Val Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Arg Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asp  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Pro  His Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Thr Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Gly Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Pro Arg Glu  Pro Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Leu Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys Arg  Cys Glu Pro Val Gln  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Glu Gly  Val Val Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Ile Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Met Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Ile Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  20
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  20

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Ala Leu Gly Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ala Asp Phe Ile Ser Thr Phe Asp Asp 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Asn Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Met Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Ser Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Val Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Glu His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Asp Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Val Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ala Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Ser Gly Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Arg Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu Arg Ala Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Pro Arg Gln Pro Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Gln Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Ser Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Thr Ser Gly Ser Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Gly Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Gln His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Thr Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Gly Ile Ser Val Ala Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Val  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Val Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Ala Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Gln Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Gln  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Leu Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Leu Asp  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Arg Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ala Arg Val  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Val  Val Leu Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Ala Pro  Glu Leu Leu Gly Val  Ser Thr Thr 
    1475                 1480                 1485             


Ala Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Arg 
    1505                 1510                 1515             


Glu Phe  Val Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Ala  Val Thr Pro 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Arg Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Gln  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Gly 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Ser  Pro Ala Thr Asp Glu  Ile Arg Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Leu  Val Pro Ile Gly Val  Gly Pro His Ala Asp  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Leu Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Ser 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Pro  His Ile Pro Thr Leu  Pro Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ala Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Tyr Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Thr Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Gln  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Val Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Leu Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Asp Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Asp Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Ala Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Gly Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Pro Ser Glu  Pro Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Ala Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Leu Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Asn Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Pro Lys  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln His  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys Arg  Cys Glu Pro Val Gln  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Leu Glu Glu Gly  Val Val Ser 
    2600                 2605                 2610             


Arg Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Val Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Met Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Ile Tyr  His Glu Val Leu Asn  Ala Leu Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  21
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  21

Met Ile Pro Ala Trp Leu Gly Arg Val Leu Leu Ala Leu Ala Phe Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Thr Pro Gly Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Val Ser Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Ser Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Leu Val Asn Gly Thr Val Leu Gln Gly Ala Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Phe Leu Glu Ser Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Val Ser Ser Glu Met Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Thr Met Leu Cys Pro Cys 
                245                 250                 255     


Ala Gln Gly Leu Gln Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Arg Gly Met Val Leu Tyr Gly Trp Thr Asp His Ser 
        275                 280                 285             


Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Arg Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys Thr Arg Thr Cys Arg Ser Pro Pro Val Ser Glu Ala Cys 
305                 310                 315                 320 


Arg Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Gly Ser Arg Cys Val Glu Ser Thr Glu Cys Ser Cys Val His Ser 
            340                 345                 350         


Gly Lys Arg Tyr Pro Pro Gly Ala Ser Phe Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn 
385                 390                 395                 400 


Lys Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Ile Ile Asp Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ser Val Cys Thr Arg Ser Val Thr Val Arg Leu Ser 
        435                 440                 445             


Ser Pro His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Val Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Met Ala Ser Val His Leu Ser Tyr Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Arg Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Ala Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ser Trp Lys Leu Arg Gly Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Arg Arg Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Gln Ser 
                565                 570                 575     


Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ser Cys Ser Asp Gly Gly Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile Ala 
625                 630                 635                 640 


Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Arg Gly Gln Val 
                645                 650                 655     


Tyr Leu Gln Cys Gly Thr Pro Cys Asn Ala Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


His Pro Asp Asp Glu Cys Asp Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Ser Gly Leu Tyr Leu Asp Glu Ala Gly Asp Cys Val Pro Arg Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val Leu 
            740                 745                 750         


Gly Gly Pro Leu Ser His Arg Ser Lys Arg Ser Leu Phe Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Ala Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Glu Thr Leu Lys Ile Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Arg Asp Arg Lys Trp Asn Cys Ser Asp His Val Cys Asp Ala 
    850                 855                 860                 


Ser Cys Ser Ala Leu Gly Leu Ala His Tyr Leu Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp His 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Gly Tyr Pro Ser Leu Lys Cys Arg Lys Arg Val Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Ser Val Lys Arg 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Ile Ser Val Val Trp Asp Arg His 
                965                 970                 975     


Leu Ser Val Ser Val Phe Leu Lys Gln Thr Tyr Gln Glu Gln Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Ala Gln Cys  Ala Asp Ala Arg Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Ala  Ser Pro Ala Thr Cys  Arg Ser Ser Val Leu  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Ile Leu Thr Ser Asp  Ile Phe Arg 
    1055                 1060                 1065             


Asp Cys  Asn Met Leu Val Asp  Pro Glu Pro Tyr Leu  Asp Ala Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Thr Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Val Ala Ala  Tyr Ala His Val Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Ser  Val Val Ala Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Ser 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Arg  Glu Gly Gly Tyr Glu  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Pro Ser 
    1145                 1150                 1155             


His Pro  Pro Leu Pro Cys Pro  Val Gln Cys Val Gln  Thr Ser Leu 
    1160                 1165                 1170             


Pro Pro  Leu Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asp Pro Lys Asp Cys  Pro Val Cys Glu Val  Ala Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Pro Gly Lys Lys  Ile Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Asp His  Cys Gln Thr Cys His  Cys Asp Gly Val Asn  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Gly Glu Leu Gly  Gly Leu Glu Ala Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Ala Ser Thr Thr Ser  Ser Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Ser Phe Leu  Cys Ser Arg Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Asn  Lys Leu Ser Glu Ala  Asp Phe Gly 
    1280                 1285                 1290             


Val Leu  Lys Asp Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Ile Ala Leu  Arg Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Ser Gln  Val Lys Tyr Ala Gly  Ser Ala Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Ser Lys  Ile Asp Arg Pro Glu  Ala Ser Arg Val Val  Leu Leu Leu 
    1370                 1375                 1380             


Val Ala  Ser Gln Glu Pro Ala  Lys Leu Ser Arg Asn  Phe Ala Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Ser Val  Val Ala Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Asn  Leu Lys Gln Val Arg  Phe Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Pro Glu Asn Lys  Ala Phe Glu Leu Gly  Gly Val Gly 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Arg Asp  Glu Ile Ile Gly Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Val Pro Ala  Pro Thr Pro His Pro  His Val Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Gly Pro Glu  Leu Leu Gly Val Ser  Thr Ala Gly 
    1475                 1480                 1485             


Pro Arg  Arg Cys Ser Val Val  Leu Asp Val Val Phe  Val Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Lys Val Gly Glu  Ala Asn Phe Asn Arg  Ser Thr Glu 
    1505                 1510                 1515             


Phe Val  Ala Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Ser 
    1520                 1525                 1530             


Val His  Val Ala Val Leu Gln  Tyr Ser His Ala Val  Ala Glu Glu 
    1535                 1540                 1545             


Tyr Ser  Phe Ser Lys Ala Gln  Ser Thr Gly Asp Val  Leu Gln Arg 
    1550                 1555                 1560             


Val Arg  Glu Ile Arg Tyr Gln  Gly Gly Asn Glu Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Thr  Glu His Ser Phe Ser  Ala Arg Glu 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Asn Pro  Ala Ser Asp Glu Ile  Arg Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Val Val  Pro Ile Gly Val Gly  Pro Ser Val Asp Arg  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Ile Gly Trp Pro Asn  Ala Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Met  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Glu Glu Arg Pro His  Leu Thr Thr Leu Ser  Pro Ala Pro 
    1670                 1675                 1680             


Ala Cys  Ser Glu Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Ser  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Thr Phe Ala 
    1700                 1705                 1710             


Lys Asp  Phe Ile Ser Lys Ala  Asn Ile Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Thr Ala  Asp Val Pro 
    1730                 1735                 1740             


Trp Asn  Val Ala Gln Ala Thr  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Leu Met  Gln Arg Glu Gly Gly  Pro Ser Gln Ile Gly  Ala Ala Leu 
    1760                 1765                 1770             


Ala Phe  Ala Val Arg Tyr Val  Thr Ser Glu Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Ala Val  Val Ile Leu Val Thr  Glu Ala Ser 
    1790                 1795                 1800             


Val Asp  Ser Val Asp Glu Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Arg Tyr  Asp Pro Ala 
    1820                 1825                 1830             


Gln Leu  Arg Thr Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Leu 
    1835                 1840                 1845             


Lys Leu  Gln Arg Ile Glu Asp  Leu Pro Thr Met Val  Thr Leu Gly 
    1850                 1855                 1860             


Asp Ser  Phe His His Lys Leu  Cys Ser Glu Phe Val  Arg Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Gly Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Pro  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Arg 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asn Ser Gln  Ser Pro Ile Arg Val  Glu Glu Thr 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Thr Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Gln Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Ser  Cys Ser Tyr Val Leu  Phe His Ser Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Val Leu His Ser Gly  Ala Cys Gly Thr Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Val Thr Ala Ile Glu  Val Lys His Asp Gly  Leu Ser Val 
    2000                 2005                 2010             


Gln Leu  Arg Ser Asp Met Gln  Val Glu Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Thr Gly Gly  Asn Leu Glu Val Ser  Ile Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Tyr Glu Val Arg  Phe Asn His Leu Gly  His Ile Phe 
    2045                 2050                 2055             


Thr Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Thr  Phe Ala Ser Lys Val  Tyr Gly Leu Cys Gly  Ile Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Lys Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Thr Asp  Trp Arg Thr Leu Val  Gln Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Gln Ser Val  Pro Glu Glu Gln Cys  Pro Val Pro 
    2120                 2125                 2130             


Gly Ala  Ser Pro Cys His Val  Ile Leu Ser Ala Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Val Ala Pro  Ala Thr Phe His Ala  Ile Cys Gln 
    2150                 2155                 2160             


Gln Glu  Ser Cys His Gln Glu  Lys Val Cys Glu Ala  Val Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Glu Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu Ser Arg Cys  Pro Gln His Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Ser Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His Gln  Val Met Leu Lys Gly  Gly Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Gly Asp Asp  Gly Thr Arg His Gln  Phe Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Arg Val Asn Cys  Thr Ala Gln Pro Cys  Pro Thr Ala 
    2285                 2290                 2295             


Arg Ala  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Gly Ser  Arg Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Thr  Cys Asp Leu Pro Leu  Val Pro Pro Cys Ala  Asp Gly Leu 
    2330                 2335                 2340             


Gln Leu  Thr Leu Thr Asn Pro  Gly Glu Cys Arg Pro  Asn Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Gln Thr Gly Pro  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Thr Pro  Ala Leu Arg Lys Thr  Gln Cys Cys 
    2375                 2380                 2385             


Glu Glu  Tyr Glu Cys Ala Cys  Asn Cys Val Ser Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Ala Leu Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Val Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Val Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Glu Asp Ser  Cys Gln Pro 
    2465                 2470                 2475             


Gly Phe  Asp Tyr Ile Leu His  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Met Ile Gly Ser Leu  Arg Gly Asp 
    2495                 2500                 2505             


Tyr His  Ser Ser Trp Lys Ser  Val Gly Ser His Trp  Val Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile His  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Ala Ile 
    2540                 2545                 2550             


Pro Thr  Cys Pro Pro Gly Phe  Gln Leu Ser Cys Lys  Thr Ser Asp 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Met Glu Ala  Cys Ile Leu 
    2570                 2575                 2580             


Asn Asp  Thr Ile Ile Gly Pro  Gly Lys Ser Leu Met  Val Asp Val 
    2585                 2590                 2595             


Cys Thr  Thr Cys Ser Cys Ala  Val Gln Glu Gly Val  Val Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Lys  Thr Thr Cys Glu Pro  Cys Pro Leu 
    2615                 2620                 2625             


Gly Tyr  Lys Glu Glu Lys Leu  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Leu 
    2645                 2650                 2655             


Thr Leu  Lys Pro Gly Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Arg Val Asn Glu Arg  Gly Gln Tyr Thr Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Gly Cys Leu Pro Phe  Asp Glu His Arg Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Val Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Ala Ala Arg Val  Gln Tyr Ile 
    2720                 2725                 2730             


Arg Val  Gly Asp Cys Gln Ser  Glu Glu Glu Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Lys Cys Thr Ser  Lys Ala Val Tyr Ser  Ile Glu Ala 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Ala Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Pro Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Val 
    2780                 2785                 2790             


His His  Glu Ile Leu Asn Ala  Met Gln Cys Thr Cys  Ser Pro Arg 
    2795                 2800                 2805             


Lys Cys  Ser Lys 
    2810         


<210>  22
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  22

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Ser Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Val Ser Ser Glu Met Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Met Leu Cys Thr Cys 
                245                 250                 255     


Ala Gln Gly Leu Gln Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Leu Leu Tyr Gly Trp Thr Asp His Ser 
        275                 280                 285             


Ala Cys Arg Pro Asp Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val Cys 
305                 310                 315                 320 


Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His Ser 
            340                 345                 350         


Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Leu Trp Val Cys Ser Asn Glu Glu Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Ile Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Pro His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Met Ala Ser Val His Leu Ser Tyr Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Gln Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ala Trp Lys Leu Arg Gly Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Lys Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Arg Phe Ala Glu Glu Ala Cys Ala Ile Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile Gly 
625                 630                 635                 640 


Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln Val 
                645                 650                 655     


Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


Tyr Pro Asp Glu Glu Cys Thr Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Pro Gly Leu Tyr Leu Asp Glu Ser Gly Asp Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Val Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala 
    850                 855                 860                 


Ser Cys Ser Ala Leu Gly Leu Ala His Tyr Leu Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Gly Tyr Pro Ser Leu Lys Cys Arg Lys Arg Val Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Ser Val Lys Arg 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His 
                965                 970                 975     


Leu Gly Ile Ser Val Phe Leu Lys Gln Thr Tyr Gln Glu Gln Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Gln Cys  Ala Asp Thr Arg Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Ser  Ser Pro Ala Thr Cys  His Asn Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Ile Leu Thr Ser Asp  Ile Phe Gln 
    1055                 1060                 1065             


Asp Cys  Asn Lys Leu Val Asp  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Thr Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Val Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Lys  Val Val Thr Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Arg  Glu Asn Gly Tyr Gln  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asn Pro Glu Asp Cys  Pro Val Cys Glu Val  Ala Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Pro Gly Lys Lys  Ile Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu His  Cys Gln Ile Cys His  Cys Asp Gly Val Asn  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Glu Val Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Ser Pro Thr Thr  Pro Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Val Leu  Lys Ala Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Ile Ala Leu  Gln Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Ser Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Gly Arg  Ile Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Thr Val  Ile Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Ser  Leu Lys Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Pro Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val Asp 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Arg Asp  Glu Ile Ile Ser Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Val Pro Ala  Pro Thr Gln Arg Pro  Leu Val Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Ala Pro Glu  Leu Leu Gly Val Ser  Thr Leu Gly 
    1475                 1480                 1485             


Pro Lys  Arg Ser Ser Met Val  Leu Asp Val Val Phe  Val Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Lys Val Gly Glu  Ala Asn Phe Asn Arg  Ser Thr Glu 
    1505                 1510                 1515             


Phe Val  Glu Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Ser 
    1520                 1525                 1530             


Val His  Val Thr Val Leu Gln  Tyr Ser Tyr Val Val  Thr Val Glu 
    1535                 1540                 1545             


His Ser  Phe Arg Glu Ala Gln  Ser Lys Gly Asp Val  Leu Gln Arg 
    1550                 1555                 1560             


Val Arg  Glu Ile Arg Tyr Gln  Gly Gly Asn Arg Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Asn Pro  Ala Ser Asp Glu Ile  Arg Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Val Val  Pro Ile Gly Val Gly  Pro His Val Asp Val  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Ile Gly Trp Pro Asn  Ala Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Thr  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Gly Glu Gly Pro His  Leu Pro Thr Leu Ala  Pro Ala Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Ser  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Lys Ala  Asn Ile Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Thr Ile  Asp Val Pro 
    1730                 1735                 1740             


Trp Asn  Val Pro Leu Glu Lys  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Leu Met  Gln Arg Glu Gly Gly  Pro Ser Gln Ile Gly  Asp Ala Leu 
    1760                 1765                 1770             


Gly Phe  Ala Val Arg Tyr Val  Thr Ser Gln Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Ala Val  Val Ile Leu Val Thr  Asp Thr Ser 
    1790                 1795                 1800             


Thr Asp  Ser Val Asp Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Arg Tyr  Asp Glu Ala 
    1820                 1825                 1830             


Gln Leu  Arg Thr Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Val 
    1835                 1840                 1845             


Lys Leu  Gln Arg Ile Glu Asp  Leu Pro Thr Met Val  Thr Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Leu His Lys Leu  Cys Ser Gly Phe Val  Arg Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Pro  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Arg 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asn Ser Gln  Ser Pro Ile Arg Val  Glu Glu Ala 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Thr Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Gln Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Asn  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Ile Leu His Asn Gly  Ala Cys Ser Ala Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Ile Glu  Val Lys His Asn Gly  Leu Ser Val 
    2000                 2005                 2010             


Glu Leu  His Ser Asp Met Glu  Val Val Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Val Gly Gly  Asn Met Glu Val Ser  Ile Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Tyr Glu Val Arg  Phe Asn His Leu Gly  His Ile Leu 
    2045                 2050                 2055             


Thr Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Thr  Phe Ala Ser Lys Met  Tyr Gly Leu Cys Gly  Ile Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Arg Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Thr Asp  Trp Lys Thr Leu Val  Gln Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Gln Pro Val  Pro Glu Glu Gln Cys  Pro Val Ser 
    2120                 2125                 2130             


Gly Gly  Ser His Cys Gln Val  Leu Leu Ser Ala Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Leu Ala Pro  Ala Thr Phe His Ala  Ile Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys His Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu His Gly Cys  Pro Arg His Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Ser Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His Gln  Val Met Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Ser Asp Asp  Gly Ile Arg His Gln  Phe Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Thr Gln Pro Cys  Pro Thr Ala 
    2285                 2290                 2295             


Arg Ala  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Ser Ala  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Leu Pro Pro  Val Pro His Cys Glu  Gly Gly Leu 
    2330                 2335                 2340             


Gln Pro  Thr Leu Thr Asn Pro  Gly Glu Cys Arg Pro  Asn Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Pro Arg Gly Pro  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Thr Pro  Ala Leu Arg Lys Thr  Gln Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Glu Cys Ala Cys  Asn Cys Val Asn Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Val Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Glu Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu His  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Tyr Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile Asn  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Thr  Cys Pro Val Gly Phe  Gln Leu Ser Cys Lys  Thr Ser Gly 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Lys Ser Leu Met  Ile Asp Val 
    2585                 2590                 2595             


Cys Thr  Thr Cys Arg Cys Thr  Val Gln Glu Gly Val  Val Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Lys  Thr Thr Cys Glu Ala  Cys Pro Leu 
    2615                 2620                 2625             


Gly Tyr  Lys Glu Glu Lys Met  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Met 
    2645                 2650                 2655             


Thr Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Arg Val Asn Glu Arg  Gly Glu Tyr Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Gly Cys Pro Pro Phe  Asp Glu His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Arg Leu  Gln Tyr Val 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Lys Ser  Glu Glu Glu Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Lys Cys Thr Ser  Lys Ala Val Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Gln Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Glu Val Leu Asn Ala  Met Gln Cys Lys Cys  Ser Pro Arg 
    2795                 2800                 2805             


Lys Cys  Ser Lys 
    2810         


<210>  23
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  23

Met Ile Pro Ala Arg Leu Ala Arg Leu Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ala Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Ser Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Thr His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Val Ser Ser Glu Leu Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Met Leu Cys Thr Cys 
                245                 250                 255     


Ala Gln Gly Leu Arg Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Leu Leu Tyr Gly Trp Thr Asp His Ser 
        275                 280                 285             


Ser Cys Arg Pro Asp Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val Cys 
305                 310                 315                 320 


Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His Ser 
            340                 345                 350         


Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Gln Trp Val Cys Ser Asn Glu Glu Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Ile Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Pro His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Met Ala Ser Val His Leu Ser Tyr Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Gln Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ser Trp Lys Leu Arg Ala Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Lys Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Arg Phe Ala Asp Glu Ala Cys Ala Ile Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile Gly 
625                 630                 635                 640 


Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro His Gly Gln Val 
                645                 650                 655     


Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


Tyr Pro Asp Glu Glu Cys Thr Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Pro Gly Leu Tyr Leu Asp Glu Thr Gly Ser Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Val Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala 
    850                 855                 860                 


Ser Cys Ser Ala Leu Gly Leu Ala His Tyr Leu Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp Tyr 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Gly Tyr Pro Ser Leu Lys Cys Arg Lys Arg Val Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Ser Val Lys Arg 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His 
                965                 970                 975     


Leu Gly Ile Ser Val Phe Leu Lys Gln Thr Tyr Gln Glu Gln Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Gln Cys  Ala Asp Thr Gln Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Ser  Ser Pro Ala Thr Cys  His Asn Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Ile Leu Thr Ser Asp  Ile Phe Gln 
    1055                 1060                 1065             


Glu Cys  Asn Arg Leu Val Asp  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Thr Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Val Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Glu  Val Val Thr Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Arg  Glu Ser Gly Tyr Gln  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asn Pro Glu Asp Cys  Pro Val Cys Glu Val  Ala Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Pro Gly Lys Lys  Ile Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu His  Cys Gln Ile Cys His  Cys Asp Gly Val Ser  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Glu Val Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Ser Pro Thr Thr  Pro Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Thr Leu  Lys Ala Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Ile Ala Leu  Gln Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Ser Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Gly Arg  Ile Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Ser Val  Val Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Ser  Leu Lys Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Pro Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val Asp 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Arg Asp  Glu Ile Ile Ser Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Val Pro Ala  Pro Thr Gln Arg Pro  Leu Thr Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Ala Pro Glu  Leu Leu Gly Val Ser  Thr Leu Gly 
    1475                 1480                 1485             


Pro Lys  Arg Ser Ser Val Val  Leu Asp Val Ala Phe  Leu Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Lys Val Gly Glu  Ala Asn Phe Asn Arg  Ser Thr Glu 
    1505                 1510                 1515             


Phe Val  Glu Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Gly 
    1520                 1525                 1530             


Val His  Val Thr Val Leu Gln  Tyr Ser Tyr Val Val  Thr Val Glu 
    1535                 1540                 1545             


His Ser  Phe Arg Glu Ala Gln  Ser Lys Glu Asp Val  Leu Gln Arg 
    1550                 1555                 1560             


Leu Arg  Glu Ile Arg Tyr Arg  Gly Gly Asn Arg Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Ser Pro  Ala Ser Asp Glu Ile  Arg Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Val Val  Pro Ile Gly Val Gly  Pro Arg Val Asp Val  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Ile Gly Trp Pro Gln  Ala Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Thr  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Gly Glu Gly Pro His  Leu Pro Thr Leu Ala  Pro Ala Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Ser  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Lys Ala  Asn Ile Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Thr Ile  Asp Val Pro 
    1730                 1735                 1740             


Trp Asn  Val Pro Leu Glu Lys  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Leu Met  Gln Arg Glu Gly Gly  Pro Ser Gln Ile Gly  Asp Ala Leu 
    1760                 1765                 1770             


Gly Phe  Ala Val Arg Tyr Val  Thr Ser Gln Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Ala Val  Val Ile Leu Val Thr  Gly Thr Ser 
    1790                 1795                 1800             


Thr Asp  Ser Val Asp Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Arg Tyr  Asp Glu Ala 
    1820                 1825                 1830             


Gln Leu  Arg Ile Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Val 
    1835                 1840                 1845             


Gln Leu  Gln Arg Ile Glu Asp  Leu Pro Thr Met Val  Ala Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Leu His Lys Leu  Cys Ser Gly Phe Val  Ser Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Pro  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Arg 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asn Ser Gln  Ser Pro Ile Arg Val  Glu Glu Ala 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Thr Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Gln Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Asn  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Ile Leu His Asn Gly  Ala Cys Ser Ala Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Ile Glu  Val Lys His Asn Gly  Leu Ser Val 
    2000                 2005                 2010             


Glu Leu  Arg Ser Asn Met Glu  Val Val Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Val Gly Gly  Asp Met Glu Val Ser  Val Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Tyr Glu Val Arg  Phe Asn His Leu Gly  His Ile Leu 
    2045                 2050                 2055             


Thr Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Thr  Phe Ala Ser Lys Met  Tyr Gly Leu Cys Gly  Ile Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Arg Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Thr Asp  Trp Lys Thr Leu Val  Gln Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Gln Leu Gly  Pro Glu Glu Pro Cys  Pro Val Ser 
    2120                 2125                 2130             


Arg Gly  Ser His Cys Gln Val  Leu Leu Ser Ala Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Leu Ala Pro  Ala Thr Phe His Ala  Ile Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys His Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu Arg Gly Cys  Pro Arg Gln Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Ser Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His Gln  Val Met Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Ser Asp Asp  Gly Ile Arg His Gln  Leu Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Thr Gln Pro Cys  Pro Thr Ala 
    2285                 2290                 2295             


Arg Ala  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Ser Thr  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Leu Pro Pro  Val Pro His Cys Glu  Gly Gly Leu 
    2330                 2335                 2340             


Gln Pro  Thr Leu Thr Asn Pro  Gly Glu Cys Arg Pro  Asn Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Pro Arg Gly Ser  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Thr Pro  Ala Leu Arg Lys Thr  Gln Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Glu Cys Ala Cys  Asn Cys Val Asn Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Val Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Glu Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu His  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Tyr Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile Tyr  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Thr  Cys Pro Val Gly Phe  Gln Leu Ser Cys Gln  Thr Ser Gly 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Lys Ser Leu Met  Val Asp Val 
    2585                 2590                 2595             


Cys Thr  Thr Cys Arg Cys Thr  Val Gln Ala Gly Val  Ile Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Gln  Thr Thr Cys Glu Ala  Cys Pro Leu 
    2615                 2620                 2625             


Gly Tyr  Lys Glu Glu Lys Met  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Met 
    2645                 2650                 2655             


Met Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Arg Val Asn Lys Arg  Gly Glu Phe Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Gly Cys Pro Pro Phe  Asp Glu His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Arg Leu  Gln Tyr Val 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Lys Ser  Glu Glu Glu Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Arg Cys Thr Ser  Lys Ala Leu Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Gln Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Val Val Leu Asn Ala  Met Gln Cys Lys Cys  Ser Pro Arg 
    2795                 2800                 2805             


Lys Cys  Arg Lys 
    2810         


<210>  24
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  24

Met Phe Pro Thr Arg Leu Ala Arg Leu Leu Leu Ala Val Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Ala Leu Gly Lys Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ala Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Lys Thr His Ser Phe Ser Ile Val Gly Asp Phe Gln Ala Gly Arg 
65                  70                  75                  80  


Arg Val Gly Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Gly Gln His Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Thr Arg Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr His Lys 
        115                 120                 125             


Leu Ser Ser Glu Ser Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Ile Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Glu Glu Gln Arg Cys Pro Arg Val Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Val Ser Ser Glu Leu Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Thr Ala Ser Val Phe Ala Arg Cys His Ala Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Met Leu Cys Ala Cys 
                245                 250                 255     


Ala Gln Gly Leu Arg Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Leu Leu Tyr Gly Trp Ala Asp His Ser 
        275                 280                 285             


Ser Cys Arg Pro Asp Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys His Arg Thr Cys Arg Ser Leu Ser Ile Thr Glu Val Cys 
305                 310                 315                 320 


Arg Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Pro Cys Val His Ala 
            340                 345                 350         


Gly Lys Pro Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Gln Trp Val Cys Ser Asn Glu Asp Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asp 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Gln Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Val Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Pro His His Gly Leu Leu Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Leu Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Thr Ala Ser Leu His Leu Ser Phe Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Leu Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Gln Arg Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ser Trp Lys Leu Arg Ala Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Glu Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Lys Phe Ala Asp Gln Ala Cys Ala Ile Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Gly Pro Leu Pro Tyr Leu Arg Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ala Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile Gly 
625                 630                 635                 640 


Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro His Gly Gln Val 
                645                 650                 655     


Tyr Gln Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


His Pro Asp Glu Glu Cys Thr Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Pro Gly Leu Phe Leu Asp Glu Thr Gly Ser Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Glu Ala Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Asp Arg Val Lys Val Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Gln Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala 
    850                 855                 860                 


Ser Cys Ser Ala Leu Gly Leu Ala His Tyr Phe Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp His 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Val Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Ser Val Pro Ser Leu Lys Cys Arg Lys Arg Ile Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Lys 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Gly His 
                965                 970                 975     


Leu Ala Val Ser Val Phe Leu Lys Arg Thr Tyr Gln Glu Arg Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Gln Cys  Ala Asp Thr Gln Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Ser  Ala Pro Ala Thr Cys  His Asn Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Val Leu Thr Ser Asp  Val Phe Arg 
    1055                 1060                 1065             


Glu Cys  Asn Arg Leu Val Asn  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Ser Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Glu Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Glu  Val Val Thr Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Lys  Glu Ser Gly Tyr Gln  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asn Pro Glu Asp Cys  Pro Val Cys Gln Val  Glu Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Ser Gly Lys Lys  Val Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu His  Cys Gln Ile Cys His  Cys Asp Gly Val Ser  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Pro Val Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Ser Pro Thr Thr  Pro Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Thr Leu  Lys Ala Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Leu Ala Leu  Gln Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Gly Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Gly Arg  Ile Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Ser Val  Val Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Ser  Leu Lys Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Ser Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val His 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Met Asp  Glu Ile Val Gly Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Val Pro Ala  Pro Thr Gln His Pro  Leu Thr Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Ala Pro Gln  Leu Leu Gly Pro Ser  Pro Pro Gly 
    1475                 1480                 1485             


Pro Lys  Arg Ser Ser Val Val  Leu Asp Val Ala Phe  Leu Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Glu Val Gly Glu  Ala Asn Phe Asn Arg  Ser Ala Glu 
    1505                 1510                 1515             


Phe Val  Glu Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Gly 
    1520                 1525                 1530             


Ile His  Val Thr Val Leu Gln  Tyr Ser Tyr Val Val  Thr Val Glu 
    1535                 1540                 1545             


His Ser  Phe Arg Glu Pro Gln  Ser Lys Glu Val Val  Leu Gln Arg 
    1550                 1555                 1560             


Leu Arg  Glu Val Arg Tyr Arg  Gly Gly Asn Gln Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Ser Pro  Ala Ser Asp Lys Ile  Gln Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Leu Val  Pro Ile Gly Val Gly  Pro Arg Val Asp Val  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Val Ser Trp Pro Gln  Thr Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Arg  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Glu Asp Gly Pro His  Leu Pro Thr Leu Ala  Pro Ala Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Thr  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Lys Ala  Asn Leu Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Asn Val  Asp Val Ser 
    1730                 1735                 1740             


Trp Asn  Val His Val Asp Lys  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Pro Met  Gln Arg Glu Gly Gly  Pro Ser Gln Val Gly  Glu Ala Leu 
    1760                 1765                 1770             


Ser Phe  Ala Val Arg Tyr Ile  Thr Ser Gln Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Val Val  Val Ile Leu Val Thr  Gly Ser Ser 
    1790                 1795                 1800             


Met Asp  Ser Val Glu Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Gln Tyr  Asp Ala Ala 
    1820                 1825                 1830             


Gln Leu  Arg Val Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Ala 
    1835                 1840                 1845             


Glu Leu  Gln Arg Ile Glu Asp  Leu Pro Ser Met Val  Ala Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Phe Gln Arg Leu  Cys Ser Gly Phe Val  Ser Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Leu  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Gln 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asp Gly Gln  Thr Pro Leu Arg Met  Glu Glu Ala 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Ala Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Arg Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Asn  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Ile Leu His Asn Gly  Phe Cys Ser Ala Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Val Glu  Val Lys His Asn Gly  Leu Ser Val 
    2000                 2005                 2010             


Glu Leu  Arg Ser Asn Met Glu  Val Met Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Leu Gly Gly  Asp Met Glu Val Arg  Val Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Phe Glu Val Arg  Phe Asn Leu Leu Gly  His Ile Leu 
    2045                 2050                 2055             


Ser Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Ile  Ser Ala Ser Lys Thr  Tyr Gly Leu Cys Gly  Phe Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Arg Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Ala Asp  Trp Lys Thr Leu Val  Arg Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Pro Leu Gly  Pro Glu Glu Pro Cys  Pro Val Ser 
    2120                 2125                 2130             


Gln Gly  Ser Arg Cys Gln Val  Leu Leu Ser Glu Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Leu Ala Pro  Ala Thr Phe His Ala  Val Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys His Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu Ser Gly Cys  Pro Arg Gln Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Leu Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His Gln  Val Met Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Gly Asp Asp  Gly Ile Arg His Gln  Leu Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Thr Gln Pro Cys  Pro Ser Ala 
    2285                 2290                 2295             


Gly Val  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Ser Thr  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Val Pro Pro  Val Pro His Cys Glu  Asp Gly Leu 
    2330                 2335                 2340             


Gln Pro  Val Leu Ser Asn Pro  Gly Glu Cys Arg Pro  Ser Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Pro Arg Gly Ser  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Met Pro  Ala Leu Arg Lys Thr  Arg Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Glu Cys Ala Cys  Asn Cys Ala Asn Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Thr Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Ala Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu His  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Gln Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile Tyr  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Ile  Cys Pro Leu Gly Phe  Gln Leu Arg Cys Gln  Thr Leu Gly 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Lys Thr Val Met  Val Asp Ala 
    2585                 2590                 2595             


Cys Met  Thr Cys Arg Cys Thr  Val Gln Ala Gly Val  Ile Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Gln  Thr Thr Cys Gln Ala  Cys Pro Val 
    2615                 2620                 2625             


Gly Tyr  Val Glu Glu Lys Leu  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Leu 
    2645                 2650                 2655             


Met Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Lys Val Asn Lys Arg  Gly Glu Phe Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Gly Cys Pro Pro Phe  Asn Glu His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Arg Val  Gln Tyr Ile 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Lys Ser  Glu Glu Glu Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Arg Cys Thr Ser  Lys Ala Leu Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Ser Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Val Ile Leu Asn Ala  Leu Gln Cys Lys Cys  Ser Ser Arg 
    2795                 2800                 2805             


Lys Cys  Arg Pro 
    2810         


<210>  25
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  25

Met Phe Pro Thr Arg Leu Ala Arg Leu Leu Leu Ala Val Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Ala Pro Gly Lys Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ala Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Lys Thr His Ser Phe Ser Ile Val Gly Asp Phe Gln Ala Gly Arg 
65                  70                  75                  80  


Arg Val Gly Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Gly Gln His Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Thr Arg Gly Leu Tyr Leu Asp Thr Glu Ala Gly Tyr His Lys 
        115                 120                 125             


Leu Ser Ser Glu Ser Tyr Gly Phe Val Ala Arg Ile Asp Ser Ser Gly 
    130                 135                 140                 


Asn Phe Gln Ile Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Glu Glu Gln Arg Cys Pro Arg Val Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Glu Leu Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Thr Ala Ser Val Phe Ala Arg Cys His Ala Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Met Leu Cys Ala Cys 
                245                 250                 255     


Ala Gln Gly Leu Arg Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Leu Leu Tyr Gly Trp Ala Asp His Ser 
        275                 280                 285             


Ser Cys Arg Pro Asp Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys His Arg Thr Cys Arg Ser Leu Ser Ile Thr Glu Val Cys 
305                 310                 315                 320 


Arg Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Pro Cys Val His Ala 
            340                 345                 350         


Gly Lys Pro Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Gln Trp Val Cys Ser Asn Glu Asp Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asp 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Gln Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Ile Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Pro His His Gly Leu Leu Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Leu Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Thr Ala Ser Leu His Leu Ser Phe Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Leu Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Gln Arg Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ser Trp Lys Leu Arg Ala Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Glu Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Lys Phe Ala Asp Gln Ala Cys Ala Ile Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Gly Pro Leu Pro Tyr Leu Arg Asn Cys Arg 
        595                 600                 605             


Phe Asp Val Cys Ala Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile Gly 
625                 630                 635                 640 


Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro His Gly Gln Val 
                645                 650                 655     


Tyr Gln Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


His Pro Asp Glu Glu Cys Thr Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Ala Gly Leu Phe Leu Asp Glu Thr Gly Ser Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Glu Ala Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Asp Arg Val Lys Val Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Gln Asp Arg Lys Trp Asn Cys Thr Asp Arg Val Cys Asp Ala 
    850                 855                 860                 


Gly Cys Ser Ala Val Gly Leu Ala His Tyr Phe Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp His 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Val Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Ser Val Pro Ser Leu Lys Cys Arg Lys Arg Ile Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Lys 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Gly His 
                965                 970                 975     


Leu Ala Ile Ser Val Phe Leu Lys Arg Thr Tyr Gln Glu Arg Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Gln Cys  Ala Asp Thr Gln Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Ser  Ala Pro Ala Thr Cys  His Asn Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Val Leu Thr Ser Asp  Val Phe Arg 
    1055                 1060                 1065             


Glu Cys  Asn Arg Leu Val Asn  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Ser Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Glu Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Glu  Val Val Thr Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Lys  Glu Ser Gly Tyr Gln  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asn Pro Glu Asp Cys  Pro Val Cys Gln Val  Glu Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Ser Gly Lys Lys  Val Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu His  Cys Gln Leu Cys His  Cys Asp Gly Val Ser  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Pro Val Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Ser Pro Thr Thr  Pro Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Thr Leu  Lys Ala Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Leu Ala Leu  Gln Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Gly Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Gly Arg  Ile Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Leu  Gln Gly Leu Lys Lys  Lys Lys Val Ser Val  Val Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Val Ser  Leu Lys Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Ser Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val His 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Met Asp  Glu Ile Val Gly Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Val Pro Ala  Pro Thr Arg His Pro  Leu Ile Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Ala Pro Gln  Leu Leu Gly Pro Ser  Pro Pro Gly 
    1475                 1480                 1485             


Pro Lys  Arg Ser Ser Val Val  Leu Asp Val Ala Phe  Leu Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Glu Val Gly Glu  Ala Asn Phe Asn Arg  Ser Ala Glu 
    1505                 1510                 1515             


Phe Val  Glu Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Gly 
    1520                 1525                 1530             


Ile His  Val Thr Val Leu Gln  Tyr Ser Tyr Thr Val  Thr Val Glu 
    1535                 1540                 1545             


His Ser  Phe Arg Glu Pro Gln  Ser Lys Glu Val Val  Leu Gln Arg 
    1550                 1555                 1560             


Leu His  Glu Val Arg Tyr Arg  Gly Gly Asn Gln Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Ser Pro  Ala Ser Asp Lys Ile  Gln Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Leu Val  Pro Ile Gly Val Gly  Pro Arg Val Asp Val  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Val Ser Trp Pro Gln  Thr Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Arg  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Glu Asp Gly Pro His  Leu Pro Thr Leu Ala  Pro Ala Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Thr  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Lys Ala  Asn Leu Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Asn Val  Asp Val Ser 
    1730                 1735                 1740             


Trp Asn  Val His Val Asp Lys  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Pro Met  Gln Arg Glu Gly Gly  Pro Ser Arg Val Gly  Glu Ala Leu 
    1760                 1765                 1770             


Ser Phe  Ala Val Arg Tyr Ile  Thr Ser Gln Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Val Val  Val Ile Leu Val Thr  Gly Ser Ser 
    1790                 1795                 1800             


Met Asp  Ser Val Glu Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Gln Tyr  Asp Ala Ala 
    1820                 1825                 1830             


Gln Leu  Arg Val Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Ala 
    1835                 1840                 1845             


Glu Leu  Gln Arg Ile Glu Asp  Leu Pro Ser Met Val  Ala Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Phe Gln Arg Leu  Cys Ser Gly Phe Val  Ser Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Leu  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Gln 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asp Gly Gln  Ile Pro Leu Arg Met  Glu Glu Ala 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Ala Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Arg Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Asn  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Ile Leu His Asn Gly  Phe Cys Ser Ala Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Val Glu  Val Lys His Ser Gly  Leu Ser Val 
    2000                 2005                 2010             


Glu Leu  Arg Ser Asn Met Glu  Val Met Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Leu Gly Gly  Asp Met Glu Val Arg  Val Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Phe Glu Val Arg  Phe Asn Leu Leu Gly  His Ile Leu 
    2045                 2050                 2055             


Ser Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Ile  Ser Ala Ser Lys Thr  Tyr Gly Leu Cys Gly  Phe Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Lys Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Ala Asp  Trp Lys Thr Leu Val  Arg Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Pro Leu Gly  Pro Glu Glu Pro Cys  Pro Val Ser 
    2120                 2125                 2130             


Gln Gly  Ser Arg Cys Gln Ala  Leu Leu Ser Glu Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Leu Ala Pro  Ala Thr Phe His Ala  Val Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys His Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu Ser Gly Cys  Pro Arg Gln Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Leu Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His His  Val Met Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Gly Asp Asp  Gly Ile Arg His Gln  Leu Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Thr Gln Pro Cys  Pro Ser Ala 
    2285                 2290                 2295             


Gly Val  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Ser Thr  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Val Pro Pro  Val Pro His Cys Glu  Asp Gly Leu 
    2330                 2335                 2340             


Gln Pro  Val Leu Ser Asn Pro  Gly Glu Cys Arg Pro  Ser Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Pro Arg Glu Ser  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Met Pro  Ala Leu Arg Lys Thr  Arg Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Glu Cys Ala Cys  Asn Cys Ala Asn Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Thr Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Ala Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu His  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Gln Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile Tyr  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Ile  Cys Pro Leu Gly Phe  Gln Leu Arg Cys Gln  Thr Leu Gly 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Lys Thr Val Met  Val Asp Ala 
    2585                 2590                 2595             


Cys Met  Thr Cys Arg Cys Thr  Val Gln Ala Gly Val  Ile Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Gln  Thr Thr Cys Gln Ala  Cys Pro Val 
    2615                 2620                 2625             


Gly Tyr  Val Glu Glu Lys Leu  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Leu 
    2645                 2650                 2655             


Met Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Lys Val Asn Lys Arg  Gly Glu Phe Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Gly Cys Pro Pro Phe  Asn Glu His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Arg Val  Gln Tyr Ile 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Lys Ser  Glu Glu Glu Val Asp  Ile Asn Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Arg Cys Thr Ser  Lys Ala Leu Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Ser Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Val Ile Leu Asn Ala  Leu Gln Cys Lys Cys  Ser Ser Arg 
    2795                 2800                 2805             


Lys Cys  Arg Pro 
    2810         


<210>  26
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  26

Met Phe Pro Thr Arg Leu Ala Arg Leu Leu Leu Ala Val Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Ala Leu Gly Lys Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ala Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Lys Thr His Ser Phe Ser Ile Val Gly Asp Phe Gln Gly Gly Arg 
65                  70                  75                  80  


Arg Val Gly Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Gly Gln His Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Thr Arg Gly Leu Tyr Leu Glu Thr Glu Ala Gly His His Lys 
        115                 120                 125             


Leu Ser Ser Glu Ser Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Ile Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Glu Glu Gln Arg Cys Pro Arg Val Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Val Ser Ser Glu Leu Gln Lys Gly Leu Trp Glu Lys Cys 
    210                 215                 220                 


Gln Leu Leu Lys Thr Ala Ser Val Phe Ala Arg Cys His Ala Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Met Leu Cys Ala Cys 
                245                 250                 255     


Ala Gln Gly Leu Arg Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Leu Leu Tyr Gly Trp Ala Asp His Ser 
        275                 280                 285             


Ser Cys Arg Pro Asp Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys Val 
    290                 295                 300                 


Ser Pro Cys His Arg Thr Cys Arg Ser Leu Ser Ile Thr Glu Val Cys 
305                 310                 315                 320 


Arg Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Thr Glu Cys Pro Cys Val His Ala 
            340                 345                 350         


Gly Lys Pro Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Gln Trp Val Cys Ser Asn Glu Asp Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asp 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Gln Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Val Val Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Pro His His Gly Leu Leu Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Leu Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Thr Ala Ser Leu His Leu Ser Phe Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Leu Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Gln Arg Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ser Trp Lys Leu Arg Ala Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Glu Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Lys Phe Ala Asp Gln Ala Cys Ala Ile Leu Thr Ser Pro Lys Phe Glu 
            580                 585                 590         


Ala Cys His Ser Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ala Cys Ser Asp Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Val Gly 
625                 630                 635                 640 


Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro His Gly Gln Val 
                645                 650                 655     


Tyr Gln Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


His Pro Asp Glu Glu Cys Thr Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Pro Gly Leu Phe Leu Asp Glu Thr Gly Ser Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Ile 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Glu Ala Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Thr Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met Ser 
785                 790                 795                 800 


Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg His 
                805                 810                 815     


Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ala Pro Gly Asp Arg Val Lys Val Asp Cys Asn Ser Cys 
        835                 840                 845             


Val Cys Gln Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala 
    850                 855                 860                 


Ser Cys Ser Ala Leu Gly Leu Ala His Tyr Phe Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp His 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Val Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Ser Val Pro Ser Leu Lys Cys Arg Lys Arg Ile Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys Thr 
    930                 935                 940                 


Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Gly His 
                965                 970                 975     


Leu Ala Val Ser Val Phe Leu Lys Arg Thr Tyr Gln Glu Arg Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Val Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Gln Cys  Ala Asp Thr Gln Lys  Val Arg Leu 
    1025                 1030                 1035             


Asp Ser  Ala Pro Ala Ile Cys  His Asp Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Arg  Val Leu Thr Ser Asp  Val Phe Arg 
    1055                 1060                 1065             


Glu Cys  Asn Arg Leu Val Asn  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Ser Cys Ser Cys  Glu Ser Ile Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Glu Cys  Ala Gln His 
    1100                 1105                 1110             


Gly Glu  Val Val Thr Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Lys  Glu Ser Gly Tyr Gln  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asn Pro Glu Asp Cys  Pro Val Cys Gln Val  Glu Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Ser Gly Lys Lys  Val Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu His  Cys Gln Ile Cys His  Cys Asp Gly Val Ser  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Pro Pro Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Thr Pro Thr Thr  Pro Tyr Val Glu Asp  Ile Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Thr Leu  Lys Ala Phe Val Val  Gly Met Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Leu Ala Leu  Gln Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Gly Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Gly Arg  Ile Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Ser Val  Val Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Ser  Leu Lys Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Ser Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val His 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Met Asp  Glu Ile Val Gly Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Leu Glu Val Pro Ala  Pro Thr Gln His Pro  Leu Thr Ala 
    1460                 1465                 1470             


Gln Val  Thr Val Ala Pro Gln  Leu Leu Gly Pro Ser  Pro Pro Gly 
    1475                 1480                 1485             


Pro Lys  Arg Ser Ser Val Val  Leu Asp Val Ala Phe  Leu Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Glu Val Gly Glu  Ala Asn Phe Asn Arg  Ser Ala Glu 
    1505                 1510                 1515             


Phe Val  Glu Glu Val Ile Arg  Arg Met Asp Val Gly  Arg Asp Gly 
    1520                 1525                 1530             


Ile His  Val Thr Val Leu Gln  Tyr Ser Tyr Val Val  Thr Val Glu 
    1535                 1540                 1545             


His Ser  Phe Arg Glu Pro Gln  Ser Lys Asp Val Val  Leu Gln Arg 
    1550                 1555                 1560             


Leu Arg  Glu Val Arg Tyr Arg  Gly Gly Asn Gln Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Glu Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Ser Pro  Ala Ser Asp Lys Ile  Gln Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Leu Val  Pro Ile Gly Val Gly  Pro Arg Val Asp Val  Gln Glu Leu 
    1625                 1630                 1635             


Glu Arg  Val Ser Trp Pro Gln  Thr Pro Ile Phe Ile  Gln Asp Phe 
    1640                 1645                 1650             


Glu Arg  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Glu Asp Gly Pro His  Leu Pro Thr Leu Ala  Pro Ala Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Thr  Ser Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Lys Ala  Asn Leu Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Asn Val  Asp Val Ser 
    1730                 1735                 1740             


Trp Asn  Ile His Val Asp Lys  Ala His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


Pro Met  Gln Arg Glu Gly Gly  Pro Ser Gln Val Gly  Glu Ala Leu 
    1760                 1765                 1770             


Ser Phe  Ala Val Arg Tyr Ile  Thr Ser Gln Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Gly  Ala Ser Lys Val Val  Val Ile Leu Val Thr  Gly Ser Ser 
    1790                 1795                 1800             


Met Asp  Ser Val Glu Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Gln Tyr  Asp Ala Ala 
    1820                 1825                 1830             


Gln Leu  Arg Val Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Ala 
    1835                 1840                 1845             


Glu Leu  Gln Arg Ile Glu Asp  Leu Pro Ser Met Val  Ala Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Phe Gln Arg Leu  Cys Ser Gly Phe Val  Ser Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Val Trp Thr 
    1880                 1885                 1890             


Leu Leu  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Lys Ser His Arg  Val Asn Cys Asp Gln  Gly Pro Gln 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asp Gly Gln  Thr Pro Leu Arg Met  Glu Glu Ala 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Ala Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Arg Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Asn  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Ile Leu His Asn Gly  Phe Cys Ser Ala Gly  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Val Glu  Val Lys Gln Asn Gly  Leu Ser Val 
    2000                 2005                 2010             


Glu Leu  Arg Ser Asn Met Glu  Val Met Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Val  Pro Tyr Leu Gly Gly  Asp Met Glu Val Arg  Val Tyr Gly 
    2030                 2035                 2040             


Thr Ile  Met Phe Glu Val Arg  Phe Asn Leu Leu Gly  His Ile Leu 
    2045                 2050                 2055             


Ser Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Ile  Ser Ala Ser Lys Thr  Tyr Gly Leu Cys Gly  Phe Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Arg Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Ala Asp  Trp Lys Thr Leu Val  Arg Glu Trp Thr Val  Gln Gln Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Pro Leu Gly  Pro Glu Glu Pro Cys  Pro Ile Ser 
    2120                 2125                 2130             


Gln Gly  Ser Arg Cys Gln Val  Leu Leu Ser Glu Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Lys Val Leu Ala Pro  Ala Thr Phe His Ala  Met Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys Gln Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Ser Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu Ser Gly Cys  Pro Arg Gln Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Leu Glu Gly Cys Phe  Cys Pro Pro 
    2225                 2230                 2235             


His Gln  Val Met Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Gly Asp Asp  Gly Ile Arg His Gln  Leu Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Thr Gln Pro Cys  Pro Ser Ala 
    2285                 2290                 2295             


Gly Val  Pro Thr Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Ser Thr  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Val Pro Pro  Val Pro Asn Cys Glu  Asp Gly Leu 
    2330                 2335                 2340             


Gln Pro  Val Leu Ala Asn Pro  Gly Glu Cys Arg Pro  Ser Phe Thr 
    2345                 2350                 2355             


Cys Ala  Cys Arg Lys Glu Glu  Cys Pro Lys Gly Ser  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Met Pro  Ala Leu Arg Lys Thr  Arg Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Glu Cys Ala Cys  Asn Cys Ala Asn Ser  Thr Val Ser 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Arg 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Thr Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Ala Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu Arg  Glu Gly Glu Cys Cys  Gly Arg Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Gln Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asn  Pro Cys Leu Ile His  Glu Cys Val Arg Val  Glu Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Val  Cys Pro Leu Gly Phe  Gln Leu Arg Cys Gln  Thr Leu Gly 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys Arg Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Lys Thr Val Met  Val Asp Ala 
    2585                 2590                 2595             


Cys Met  Thr Cys Arg Cys Thr  Val Gln Ala Gly Val  Ile Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Lys  Thr Thr Cys Gln Ala  Cys Pro Ala 
    2615                 2620                 2625             


Gly Tyr  Val Glu Glu Lys Leu  Gln Gly Glu Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Thr Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Leu 
    2645                 2650                 2655             


Met Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Lys Val Asn Lys Arg  Gly Glu Phe Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Met  Ser Cys Pro Pro Phe  Asn Glu His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Glu Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Arg Val  Lys Ser Ile 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Lys Ser  Glu Asp Glu Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Arg Cys Thr Ser  Lys Ala Leu Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ser Cys Cys Ser Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Ser Val Pro Leu  Arg Cys Thr Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Val Ile Leu Asn Ala  Leu Gln Cys Gln Cys  Ser Ser Arg 
    2795                 2800                 2805             


Lys Cys  Arg Pro 
    2810         


<210>  27
<211>  2812
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  27

Met Ile Pro Ala Arg Leu Thr Arg Leu Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ala Leu Cys Gly Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Gly Asp Ser Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Glu Gly Ser Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Thr His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Val Cys Asn Val Ser Ser Glu Leu Gln Lys Gly Leu Trp Glu Gln Cys 
    210                 215                 220                 


Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu Val 
225                 230                 235                 240 


Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Met Leu Cys Thr Cys 
                245                 250                 255     


Ala Gln Gly Leu Leu Cys Pro Cys Pro Val Leu Leu Glu Tyr Ala Arg 
            260                 265                 270         


Ala Cys Ala Gln Gln Gly Met Leu Leu Tyr Gly Trp Thr Asp His Ser 
        275                 280                 285             


Ser Cys Arg Pro Asp Cys Pro Ala Gly Met Glu Tyr Lys Ala Cys Val 
    290                 295                 300                 


Ser Pro Cys Pro Arg Asn Cys Gln Ser Leu His Ile Asn Glu Val Cys 
305                 310                 315                 320 


Gln Gln Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu Leu 
                325                 330                 335     


Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His Ser 
            340                 345                 350         


Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn Thr 
        355                 360                 365             


Cys Ile Cys Arg Asn Ser Gln Trp Val Cys Ser Asn Glu Glu Cys Pro 
    370                 375                 380                 


Gly Glu Cys Leu Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp Asn 
385                 390                 395                 400 


Arg His Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg Asp 
                405                 410                 415     


Cys Gln Asp His Ser Phe Ser Ile Ile Ile Glu Thr Val Gln Cys Ala 
            420                 425                 430         


Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu Pro 
        435                 440                 445             


Ser Gln His Asn Asn Val Val Lys Leu Lys His Gly Gly Gly Val Ala 
    450                 455                 460                 


Met Asp Gly Gln Asp Ile Gln Ile Pro Leu Leu Gln Gly Asp Leu Arg 
465                 470                 475                 480 


Ile Gln His Thr Val Met Ala Ser Val His Leu Ser Tyr Gly Glu Asp 
                485                 490                 495     


Leu Gln Ile Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu Ser 
            500                 505                 510         


Pro Val Tyr Ser Gly Arg Thr Cys Gly Leu Cys Gly Asn Tyr Asn Gly 
        515                 520                 525             


Asn Gln Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro Leu 
    530                 535                 540                 


Val Glu His Phe Gly Asn Ser Trp Lys Leu Arg Ala Asp Cys Glu Asp 
545                 550                 555                 560 


Leu Gln Lys Gln Pro Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu Thr 
                565                 570                 575     


Arg Phe Ala Asp Glu Ser Cys Ala Ile Leu Thr Ser Pro Lys Phe Lys 
            580                 585                 590         


Ala Cys His Gly Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys Arg 
        595                 600                 605             


Tyr Asp Val Cys Ser Cys Thr Asn Gly Arg Asp Cys Leu Cys Asp Ala 
    610                 615                 620                 


Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val Arg Ile Gly 
625                 630                 635                 640 


Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro His Gly Gln Val 
                645                 650                 655     


Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu Ser 
            660                 665                 670         


Tyr Pro Asp Glu Glu Cys Thr Glu Val Cys Leu Glu Gly Cys Phe Cys 
        675                 680                 685             


Pro Leu Gly Leu Tyr Leu Asp Glu Thr Gly Ala Cys Val Pro Lys Ala 
    690                 695                 700                 


Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp Val 
705                 710                 715                 720 


Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met His 
                725                 730                 735     


Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Ser Val Leu 
            740                 745                 750         


Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg Pro 
        755                 760                 765             


Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu Gly 
    770                 775                 780                 


Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Val Ser 
785                 790                 795                 800 


Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg Gln 
                805                 810                 815     


Asp Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln Gly 
            820                 825                 830         


Arg Glu Tyr Ser Pro Gly Glu Thr Val Lys Val Asp Cys Asn Thr Cys 
        835                 840                 845             


Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp Ala 
    850                 855                 860                 


Thr Cys Ser Ala Leu Gly Leu Ala His Tyr Leu Thr Phe Asp Gly Leu 
865                 870                 875                 880 


Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp Tyr 
                885                 890                 895     


Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu Gly 
            900                 905                 910         


Cys Gly Tyr Pro Ser Leu Lys Cys Arg Lys Arg Val Thr Ile Leu Val 
        915                 920                 925             


Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Ser Val Lys Arg 
    930                 935                 940                 


Ser Met Lys Asp Glu Thr Tyr Phe Glu Val Val Glu Ser Gly Leu Tyr 
945                 950                 955                 960 


Ile Thr Val Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg His 
                965                 970                 975     


Leu Gly Ile Ser Val Phe Leu Lys Gln Thr Tyr Gln Glu Gln Val Cys 
            980                 985                 990         


Gly Leu Cys Gly Asn Phe Asp Gly  Ile Gln Asn Asn Asp  Leu Thr Ser 
        995                 1000                 1005             


Ser Ser  Leu Gln Val Glu Glu  Asp Pro Val Asp Phe  Gly Asn Ser 
    1010                 1015                 1020             


Trp Lys  Val Ser Pro Arg Cys  Ala Asp Thr Gln Lys  Val Pro Leu 
    1025                 1030                 1035             


Asp Pro  Ser Pro Ala Thr Cys  His Asn Asn Val Met  Lys Gln Thr 
    1040                 1045                 1050             


Met Val  Asp Ser Ser Cys Ser  Ile Leu Thr Ser Asp  Ile Phe Gln 
    1055                 1060                 1065             


Glu Cys  Asn Arg Leu Val Asp  Pro Glu Pro Tyr Leu  Asp Val Cys 
    1070                 1075                 1080             


Ile Tyr  Asp Thr Cys Ser Cys  Glu Ser Val Gly Asp  Cys Ala Cys 
    1085                 1090                 1095             


Phe Cys  Asp Thr Ile Ala Ala  Tyr Ala His Val Cys  Ala Arg His 
    1100                 1105                 1110             


Gly Glu  Val Val Ala Trp Arg  Thr Ala Thr Leu Cys  Pro Gln Asn 
    1115                 1120                 1125             


Cys Glu  Glu Arg Asn Leu Arg  Glu Ser Gly Tyr Gln  Cys Glu Trp 
    1130                 1135                 1140             


Arg Tyr  Asn Ser Cys Ala Pro  Ala Cys Pro Val Thr  Cys Gln His 
    1145                 1150                 1155             


Pro Glu  Pro Leu Ala Cys Pro  Val Gln Cys Val Glu  Gly Cys His 
    1160                 1165                 1170             


Ala His  Cys Pro Pro Gly Lys  Ile Leu Asp Glu Leu  Leu Gln Thr 
    1175                 1180                 1185             


Cys Val  Asn Pro Glu Asp Cys  Pro Val Cys Glu Ala  Ala Gly Arg 
    1190                 1195                 1200             


Arg Leu  Ala Pro Gly Lys Lys  Ile Thr Leu Asn Pro  Gly Asp Pro 
    1205                 1210                 1215             


Glu Arg  Cys Gln Ile Cys His  Cys Asp Gly Val Ser  Leu Thr Cys 
    1220                 1225                 1230             


Glu Ala  Cys Arg Glu Pro Gly  Gly Leu Ala Val Pro  Pro Thr Glu 
    1235                 1240                 1245             


Gly Pro  Val Asp Leu Thr Thr  Pro Tyr Val Glu Asp  Thr Pro Glu 
    1250                 1255                 1260             


Pro Pro  Leu His Asp Phe Phe  Cys Ser Lys Leu Leu  Asp Leu Val 
    1265                 1270                 1275             


Phe Leu  Leu Asp Gly Ser Ser  Lys Leu Ser Glu Ala  Asp Phe Glu 
    1280                 1285                 1290             


Thr Leu  Lys Ala Phe Val Val  Gly Val Met Glu Arg  Leu His Ile 
    1295                 1300                 1305             


Ser Gln  Lys Arg Ile Arg Val  Ala Val Val Glu Tyr  His Asp Gly 
    1310                 1315                 1320             


Ser His  Ala Tyr Ile Ala Leu  Gln Asp Arg Lys Arg  Pro Ser Glu 
    1325                 1330                 1335             


Leu Arg  Arg Ile Ala Ser Gln  Val Lys Tyr Ala Gly  Ser Glu Val 
    1340                 1345                 1350             


Ala Ser  Thr Ser Glu Val Leu  Lys Tyr Thr Leu Phe  Gln Ile Phe 
    1355                 1360                 1365             


Ser Arg  Val Asp Arg Pro Glu  Ala Ser Arg Val Ala  Leu Leu Leu 
    1370                 1375                 1380             


Thr Ala  Ser Gln Glu Pro Pro  Arg Leu Ala Arg Asn  Leu Val Arg 
    1385                 1390                 1395             


Tyr Val  Gln Gly Leu Lys Lys  Lys Lys Val Val Leu  Val Pro Val 
    1400                 1405                 1410             


Gly Ile  Gly Pro His Ala Ser  Leu Arg Gln Ile Arg  Leu Ile Glu 
    1415                 1420                 1425             


Lys Gln  Ala Pro Glu Asn Lys  Ala Phe Val Leu Ser  Gly Val Asp 
    1430                 1435                 1440             


Glu Leu  Glu Gln Arg Arg Asp  Glu Ile Ile Ser Tyr  Leu Cys Asp 
    1445                 1450                 1455             


Leu Ala  Pro Glu Ala Pro Ala  Pro Thr Gln Arg Pro  Leu Thr Ala 
    1460                 1465                 1470             


Gln Val  Pro Val Thr Pro Glu  Pro Pro Gly Thr Ser  Thr Leu Ala 
    1475                 1480                 1485             


Pro Arg  Arg Ser Ser Val Val  Leu Asp Val Ala Phe  Leu Leu Glu 
    1490                 1495                 1500             


Gly Ser  Asp Ser Val Gly Glu  Ala Ser Phe Asn Arg  Ser Thr Glu 
    1505                 1510                 1515             


Phe Leu  Glu Glu Val Ile Arg  Gln Met Asp Val Gly  Arg Asp Gly 
    1520                 1525                 1530             


Val His  Val Thr Val Leu Gln  Tyr Ser Tyr Val Val  Thr Val Glu 
    1535                 1540                 1545             


His Ser  Phe Arg Glu Ala Gln  Ser Lys Glu Asp Val  Leu Arg Arg 
    1550                 1555                 1560             


Leu Arg  Glu Ile Arg Tyr Arg  Gly Gly Asn Arg Thr  Asn Thr Gly 
    1565                 1570                 1575             


Leu Ala  Leu Gln Tyr Leu Ser  Glu His Ser Phe Ser  Ala Ser Gln 
    1580                 1585                 1590             


Gly Asp  Arg Gly Gln Ala Pro  Asn Leu Val Tyr Met  Val Thr Gly 
    1595                 1600                 1605             


Ser Pro  Ala Ser Asp Glu Ile  Arg Arg Met Pro Gly  Asp Ile Gln 
    1610                 1615                 1620             


Val Val  Pro Ile Gly Val Gly  Pro Arg Val Asp Val  Pro Glu Leu 
    1625                 1630                 1635             


Glu Lys  Ile Gly Trp Pro Gln  Ala Pro Ile Phe Ile  Lys Asp Phe 
    1640                 1645                 1650             


Glu Thr  Leu Pro Arg Glu Ala  Pro Asp Leu Val Leu  Gln Arg Cys 
    1655                 1660                 1665             


Cys Ser  Arg Glu Gly Pro His  Leu Pro Thr Tyr Ala  Pro Val Pro 
    1670                 1675                 1680             


Asp Cys  Ser Gln Pro Leu Asp  Val Val Leu Leu Leu  Asp Gly Ser 
    1685                 1690                 1695             


Ser Ser  Phe Pro Ala Ser Tyr  Phe Asp Glu Met Lys  Ser Phe Ala 
    1700                 1705                 1710             


Lys Ala  Phe Ile Ser Arg Ala  Asn Ile Gly Pro Gln  Leu Thr Gln 
    1715                 1720                 1725             


Val Ser  Val Leu Gln Tyr Gly  Ser Ile Thr Thr Ile  Asp Val Pro 
    1730                 1735                 1740             


Trp Thr  Val Pro Leu Glu Lys  Thr His Leu Leu Ser  Leu Val Asp 
    1745                 1750                 1755             


His Met  Gln Gln Glu Gly Gly  Pro Ser Gln Ile Gly  Asn Ala Leu 
    1760                 1765                 1770             


Gly Phe  Ala Val Arg Tyr Val  Thr Ser Gln Val His  Gly Ala Arg 
    1775                 1780                 1785             


Pro Glu  Ala Ser Lys Ala Val  Val Ile Leu Val Met  Gly Thr Ser 
    1790                 1795                 1800             


Thr Asp  Ser Val Asp Ala Ala  Ala Ala Ala Ala Arg  Ser Asn Arg 
    1805                 1810                 1815             


Val Ala  Val Phe Pro Ile Gly  Ile Gly Asp Gly Tyr  Asp Leu Ala 
    1820                 1825                 1830             


Gln Leu  Arg Ile Leu Ala Gly  Pro Gly Ala Ser Ser  Asn Val Val 
    1835                 1840                 1845             


Gln Leu  Gln Arg Ile Glu Asp  Leu Pro Thr Met Val  Ala Leu Gly 
    1850                 1855                 1860             


Asn Ser  Phe Leu His Lys Leu  Cys Ser Gly Phe Ile  Ser Val Cys 
    1865                 1870                 1875             


Val Asp  Glu Asp Gly Asn Glu  Arg Arg Pro Gly Asp  Ile Trp Thr 
    1880                 1885                 1890             


Leu Pro  Asp Gln Cys His Thr  Val Thr Cys Leu Pro  Asp Gly Gln 
    1895                 1900                 1905             


Thr Leu  Leu Asn Ser His Arg  Val Asn Cys Asp Gln  Gln Leu Arg 
    1910                 1915                 1920             


Pro Ser  Cys Pro Asn Ser Gln  Ser Pro Ile Arg Val  Glu Glu Ala 
    1925                 1930                 1935             


Cys Gly  Cys Arg Trp Thr Cys  Pro Cys Val Cys Thr  Gly Ser Ser 
    1940                 1945                 1950             


Thr Arg  His Ile Val Thr Phe  Asp Gly Gln Asn Phe  Lys Leu Thr 
    1955                 1960                 1965             


Gly Asn  Cys Ser Tyr Val Leu  Phe His Asn Lys Glu  Gln Asp Leu 
    1970                 1975                 1980             


Glu Val  Leu Leu His Asn Asp  Ala Cys Ser Ala Arg  Ala Arg Gln 
    1985                 1990                 1995             


Ala Cys  Met Lys Ser Ile Glu  Val Lys His Asn Gly  Val Ser Val 
    2000                 2005                 2010             


Glu Leu  Arg Ser Asn Met Glu  Val Val Val Asn Gly  Arg Leu Val 
    2015                 2020                 2025             


Ser Ala  Pro Tyr Val Gly Gly  Asp Met Glu Val Ser  Val Tyr Gly 
    2030                 2035                 2040             


Ala Ile  Met Tyr Glu Val Arg  Leu Asn His Leu Gly  His Ile Leu 
    2045                 2050                 2055             


Thr Phe  Thr Pro Gln Asn Asn  Glu Phe Gln Leu Gln  Leu Ser Pro 
    2060                 2065                 2070             


Lys Thr  Phe Ala Ser Lys Met  Tyr Gly Leu Cys Gly  Ile Cys Asp 
    2075                 2080                 2085             


Glu Asn  Gly Ala Asn Asp Phe  Met Leu Arg Asp Gly  Thr Val Thr 
    2090                 2095                 2100             


Ser Asp  Trp Lys Thr Leu Val  Gln Glu Trp Thr Val  Gln Lys Pro 
    2105                 2110                 2115             


Gly Gln  Thr Cys Leu Leu Gly  Pro Glu Glu Pro Cys  Pro Ile Ser 
    2120                 2125                 2130             


Arg Gly  Ser His Cys Gln Val  Leu Leu Ser Ala Leu  Phe Ala Glu 
    2135                 2140                 2145             


Cys His  Ala Val Leu Ala Pro  Ala Thr Phe His Ala  Ile Cys Gln 
    2150                 2155                 2160             


Gln Asp  Ser Cys His Gln Glu  Gln Val Cys Glu Ala  Ile Ala Ser 
    2165                 2170                 2175             


Tyr Ala  His Leu Cys Arg Thr  Lys Gly Val Cys Val  Asp Trp Arg 
    2180                 2185                 2190             


Thr Pro  Asp Phe Cys Ala Val  Pro Cys Pro Pro Ser  Leu Val Tyr 
    2195                 2200                 2205             


Asn His  Cys Glu Arg Gly Cys  Pro Arg Gln Cys Glu  Gly Asn Ser 
    2210                 2215                 2220             


Ser Ser  Cys Gly Asp His Pro  Ser Glu Gly Cys Phe  Cys Pro Leu 
    2225                 2230                 2235             


His Gln  Val Leu Leu Glu Gly  Ser Cys Val Pro Glu  Glu Ala Cys 
    2240                 2245                 2250             


Thr Gln  Cys Val Ser Asp Asp  Gly Ile Arg His Gln  Leu Leu Glu 
    2255                 2260                 2265             


Thr Trp  Val Pro Asp His Gln  Pro Cys Gln Ile Cys  Thr Cys Leu 
    2270                 2275                 2280             


Ser Gly  Arg Lys Val Asn Cys  Thr Thr Gln Pro Cys  Pro Thr Ala 
    2285                 2290                 2295             


Arg Ala  Pro Ala Cys Gly Pro  Cys Glu Val Ala Arg  Leu Arg Gln 
    2300                 2305                 2310             


Ser Thr  Gln Gln Cys Cys Pro  Glu Tyr Glu Cys Val  Cys Asp Leu 
    2315                 2320                 2325             


Val Ser  Cys Asp Leu Pro Pro  Val Pro His Cys Glu  Gly Gly Leu 
    2330                 2335                 2340             


Gln Pro  Thr Leu Thr Asn Pro  Gly Glu Cys Arg Pro  Asn Phe Thr 
    2345                 2350                 2355             


Cys Ser  Cys Arg Lys Glu Glu  Cys Pro Arg Gly Ser  Pro Pro Ser 
    2360                 2365                 2370             


Cys Pro  Pro His Arg Thr Pro  Val Leu Gln Lys Thr  Gln Cys Cys 
    2375                 2380                 2385             


Asp Glu  Tyr Lys Cys Val Cys  Asn Cys Thr Ser Ser  Ala Val Thr 
    2390                 2395                 2400             


Cys Pro  Leu Gly Tyr Leu Ala  Ser Thr Val Thr Asn  Asp Cys Gly 
    2405                 2410                 2415             


Cys Thr  Thr Thr Thr Cys Leu  Pro Asp Lys Val Cys  Val His Gln 
    2420                 2425                 2430             


Gly Thr  Ile Tyr Pro Val Gly  Gln Phe Trp Glu Glu  Gly Cys Asp 
    2435                 2440                 2445             


Val Cys  Thr Cys Thr Asp Leu  Glu Asp Ala Val Met  Gly Leu Arg 
    2450                 2455                 2460             


Val Ala  Gln Cys Ser Gln Lys  Pro Cys Gly Asp Ser  Cys Arg Pro 
    2465                 2470                 2475             


Gly Phe  Thr Tyr Val Leu His  Glu Gly Glu Cys Cys  Gly Thr Cys 
    2480                 2485                 2490             


Leu Pro  Ser Ala Cys Glu Val  Val Thr Gly Ser Pro  Arg Gly Asp 
    2495                 2500                 2505             


Ser Gln  Ser Tyr Trp Lys Ser  Val Gly Ser His Trp  Ala Ser Pro 
    2510                 2515                 2520             


Glu Asp  Pro Cys Leu Ile Tyr  Glu Cys Val Arg Val  Lys Glu Glu 
    2525                 2530                 2535             


Val Phe  Val Gln Gln Arg Asn  Val Ser Cys Pro Gln  Leu Asp Val 
    2540                 2545                 2550             


Pro Thr  Cys Pro Ser Gly Phe  Gln Leu Ser Cys Gln  Thr Ser Gly 
    2555                 2560                 2565             


Cys Cys  Pro Thr Cys His Cys  Glu Pro Val Gln Ala  Cys Val Leu 
    2570                 2575                 2580             


Asn Gly  Thr Ile Ile Gly Pro  Gly Arg Ser Leu Met  Val Asp Leu 
    2585                 2590                 2595             


Cys Thr  Thr Cys Leu Cys Thr  Val Gln Val Gly Val  Ile Ser Gly 
    2600                 2605                 2610             


Phe Lys  Leu Glu Cys Arg Gln  Thr Thr Cys Glu Asp  Cys Pro Leu 
    2615                 2620                 2625             


Gly Tyr  Lys Glu Glu Lys Met  Gln Gly Gln Cys Cys  Gly Arg Cys 
    2630                 2635                 2640             


Leu Pro  Met Ala Cys Thr Ile  Gln Leu Arg Gly Gly  Gln Ile Met 
    2645                 2650                 2655             


Met Leu  Lys Arg Asp Glu Thr  Leu Gln Asp Gly Cys  Asp Ser His 
    2660                 2665                 2670             


Phe Cys  Arg Val Asn Lys Arg  Gly Glu Phe Ile Trp  Glu Lys Arg 
    2675                 2680                 2685             


Val Thr  Gly Cys Pro Pro Phe  Asp Gly His Lys Cys  Leu Ala Glu 
    2690                 2695                 2700             


Gly Gly  Lys Ile Met Lys Ile  Pro Gly Thr Cys Cys  Asp Thr Cys 
    2705                 2710                 2715             


Glu Glu  Pro Glu Cys Lys Asp  Ile Thr Ala Lys Leu  Gln Tyr Val 
    2720                 2725                 2730             


Lys Val  Gly Asp Cys Leu Ser  Glu Glu Gln Val Asp  Ile His Tyr 
    2735                 2740                 2745             


Cys Gln  Gly Arg Cys Thr Ser  Lys Ala Leu Tyr Ser  Ile Asp Thr 
    2750                 2755                 2760             


Glu Asp  Val Gln Asp Gln Cys  Ala Cys Cys Ala Pro  Thr Arg Thr 
    2765                 2770                 2775             


Glu Pro  Met Gln Val Pro Leu  Arg Cys Ala Asn Gly  Ser Ile Ile 
    2780                 2785                 2790             


His His  Val Val Leu Asn Ala  Met Gln Cys Lys Cys  Ser Pro Arg 
    2795                 2800                 2805             


Lys Cys  Arg Gln 
    2810         


<210>  28
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  28

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Leu Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Ser Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Met Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Thr Val Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Ser Leu Cys Pro 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Gly Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu Arg Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Gly 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Arg Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser His Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Ser Gly Thr Phe Arg Ile Leu Val Ala Asn Glu 
            900                 905                 910         


Gly Cys Val Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Glu Gly Glu Ile Glu Leu Phe Asn Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Arg Asp Asp Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asn Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Ser  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Ile  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Asp Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Gln Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Gln  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Met 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Lys Pro  Gly Val Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Ala Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Pro Pro  Ala Pro Thr Gln Arg  Pro Arg Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Ser Pro  Glu Leu Leu Gly Val  Ser Ser Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Leu Glu Ala  Gln Ser Lys Arg Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Asp Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Arg Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Ser Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Leu Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Ser Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Asp Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Ser Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Phe Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Leu Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Gln His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Gly Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Asn Cys Asp Pro Pro  Leu Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Ala Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Gln  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Ala Cys  Thr Thr Cys Arg Cys  Thr Val Gln Val Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Ile Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Thr 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Met Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Ile  Met Ser Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Asn  Val Pro Gly Thr Cys  Cys Asn Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Glu Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Ile Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Asn Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  29
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  29

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Ser Leu Gly Arg Ser Pro Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Ser Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Ser Phe Gln Ile Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Ser Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Met Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Ser Ser Ser 
        195                 200                 205             


Ser Cys Asn Ala Ala Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Arg Asp Ser Val Phe Thr Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala His Gln Gly Met Val Leu Tyr Gly Trp Thr Glu His 
        275                 280                 285             


Ser Glu Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Lys Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Thr Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Ile Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asp Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Ala Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Ile 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Phe Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Arg Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Ala Asp Cys Ala 
545                 550                 555                 560 


Asp Leu Gln Gln Gln His Ser Asp Pro Cys Lys Leu Asn Pro Arg Leu 
                565                 570                 575     


Ala Lys Phe Ala Glu Glu Ala Cys Ser Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Thr Glu Leu Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ser Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Met Ser Gly Ala Pro Gly Ser Leu Leu Pro Gln His Ile 
            740                 745                 750         


Val Leu Gly Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asn Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Val Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Val Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Gly Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Ser Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Leu Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Ile  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gly Asp  Cys Pro Val Cys Glu  Val Ser Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Gly Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Glu Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Phe Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Pro  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Val Phe Val  Val Asp Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Leu Val Glu  Tyr His Glu 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gln  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Met  Arg Arg Leu Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Ala 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Gln Lys Leu Gly Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Val Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu His Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Gln Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Arg Arg Met Asp Val  Gly Gln Glu 
    1520                 1525                 1530             


Ser Ile  His Val Ser Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Thr  Thr Phe Arg Glu Thr  Gln Ser Lys Gln Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Ser  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Thr Phe  Ser Ala Ser 
    1580                 1585                 1590             


Leu Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Ala Asn  Pro Ala Ser Asp Val  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Pro Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Glu Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Met Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Gly Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


His Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Val Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Thr Gln Leu Leu  Gly Leu Val 
    1745                 1750                 1755             


Asp Gln  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Gly  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Gly Ala 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Ala Ala  Ala Ala Glu Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Pro 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln His Ile Glu  Asp Leu Pro Thr Ile  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Tyr  Ile Gly Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Asn Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Leu Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Gly Val Asn  Gly Ile Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Met Gly  Gly Asp Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Val Gln Asp Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Lys Thr Cys Gln Pro  Val Pro Glu Glu Glu  Cys Pro Ile 
    2120                 2125                 2130             


Ser Ser  Thr Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Phe Ala  Pro Ala Thr Phe Tyr  Ala Met Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Leu  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Ser Ser  Ser Cys Gly Asn His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Ser His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser His Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Val Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Thr Cys  Pro Leu Gly Tyr Leu  Ser Ser Ala Ile Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Ile Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Val Tyr Pro Ile  Gly Gln Leu Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Ile  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Glu  Ser Cys Gln 
    2465                 2470                 2475             


Leu Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ile Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Asp Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Ala Ser Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Met  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Ala Gln Val Gly  Ile Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Ser  Lys Thr Thr Cys Thr  Ala Cys Pro 
    2615                 2620                 2625             


Glu Gly  Tyr Lys Glu Glu Asn  Ile Pro Gly Glu Cys  Cys Trp Arg 
    2630                 2635                 2640             


Cys Leu  Pro Val Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Gln Arg Asp Glu  Met Phe Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Gln Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Leu Tyr  Ser Ile Glu 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Ile 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  30
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  30

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Ser Leu Gly Arg Ser Pro Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Ser Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Ala Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Ser Ile Gln Ile Leu Leu Ser Asp Arg Tyr Ser Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Ser Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Met Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Ser Ser Ser 
        195                 200                 205             


Ser Cys Asn Ala Ala Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Arg Asp Ser Val Phe Thr Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala His Gln Gly Met Val Leu Tyr Gly Trp Thr Glu His 
        275                 280                 285             


Ser Glu Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Lys Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Thr Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Ile Ile Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asp Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Ala Arg Leu 
        435                 440                 445             


Pro Ser Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Ile 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Arg Thr Cys Gly Leu Cys Gly Asn Phe Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Arg Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Ala Asp Cys Ala 
545                 550                 555                 560 


Asp Leu Arg Gln Gln His Ser Asp Pro Cys Lys Leu Asn Pro Arg Leu 
                565                 570                 575     


Ala Lys Phe Ala Glu Glu Ala Cys Ser Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Gly Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Thr Glu Leu Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ser Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Ser Met Ser Gly Ala Pro Gly Ser Leu Leu Pro Gln His Ile 
            740                 745                 750         


Val Leu Gly Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asn Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Val Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Thr Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Val Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Gly Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Ser Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Leu Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Ile  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gly Asp  Cys Pro Val Cys Glu  Val Ser Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Gly Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Glu Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Phe Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Pro  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Val Phe Val  Val Asp Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Leu Val Glu  Tyr His Glu 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gln  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Met  Arg Arg Leu Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Ala 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Gln Lys Leu Gly Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Val Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu His Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Gln Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Leu Glu Ala Val Ile  Arg Arg Met Asp Val  Gly Gln Glu 
    1520                 1525                 1530             


Ser Ile  His Val Ser Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Thr  Thr Phe Arg Glu Thr  Gln Ser Lys Gln Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Ser  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Thr Phe  Ser Ala Ser 
    1580                 1585                 1590             


Leu Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Ala Asn  Pro Ala Ser Asp Val  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Pro Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Glu Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Met Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Gly Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


His Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Val Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Thr Gln Leu Leu  Gly Leu Val 
    1745                 1750                 1755             


Asp Gln  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Gly  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Gly Ala 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Ala Ala  Ala Ala Glu Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Pro 
    1820                 1825                 1830             


Ala Gln  Leu Lys Ile Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln His Ile Glu  Asp Leu Pro Thr Ile  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Tyr  Ile Gly Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Asn Ser His  Arg Val Asn Cys Glu  Arg Gly Pro 
    1910                 1915                 1920             


Lys Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Leu Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asn  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Gly Val Asn  Gly Ile Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Met Gly  Gly Asp Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Val Gln Asp Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Lys Thr Cys Gln Pro  Val Pro Glu Glu Glu  Cys Pro Ile 
    2120                 2125                 2130             


Ser Ser  Thr Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Phe Ala  Pro Ala Thr Phe Tyr  Ala Met Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Leu  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Ser Ser  Ser Cys Gly Asn His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Ser His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser His Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Val Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Thr Cys  Pro Leu Gly Tyr Leu  Ser Ser Ala Ile Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Ile Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Val Tyr Pro Ile  Gly Gln Leu Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Ile  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Glu  Ser Cys Gln 
    2465                 2470                 2475             


Leu Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ile Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Asp Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Ala Ser Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Met  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Ala Gln Val Gly  Ile Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Ser  Lys Thr Thr Cys Thr  Ala Cys Pro 
    2615                 2620                 2625             


Glu Gly  Tyr Lys Glu Glu Asn  Ile Pro Gly Glu Cys  Cys Trp Arg 
    2630                 2635                 2640             


Cys Leu  Pro Val Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Gln Arg Asp Glu  Met Phe Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Gln Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Ile Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Leu Tyr  Ser Ile Glu 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Ile 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  31
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  31

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Lys Gly Thr Val Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Val Lys Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Gln 
                405                 410                 415     


Asp Cys Gln Asp His Thr Phe Ser Val Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Arg Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ser Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Met Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Arg Gly Asp Asp Phe Val Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Gly Pro Leu Pro Tyr Val Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Asp Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Gln Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly His 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


Arg Leu Ser Ile Ser Val Ala Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Arg Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Ala Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  His Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Gly Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  His Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln His  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu Leu Leu Gly Val  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Lys Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Glu  Val Leu Gln 
    1550                 1555                 1560             


Gln Val  Arg Glu Ile Arg Tyr  Arg Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Thr 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Tyr Glu  Lys Val His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Lys Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Pro Pro Leu Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Gln Leu Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asp Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Thr  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Ala Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Lys Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Met Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Leu Tyr  Ala His Leu Cys Arg  Thr Lys Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Arg  Thr Asn Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg Leu Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Ala His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Glu Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Met Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Asp  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Phe Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Asn Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser His Trp Lys  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Asp  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Leu Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Met Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  32
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  32

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Lys Gly Thr Val Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Gly Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Thr Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Val Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Gln Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Arg Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Ala Val Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Val Lys Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Gly Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Gln Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Gln 
                405                 410                 415     


Asp Cys Gln Asp His Thr Phe Ser Val Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Arg Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ser Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Met Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Arg Gly Asp Asp Phe Val Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Gly Pro Gln Pro Tyr Val Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Asp Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Gln Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly His 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


Arg Leu Ser Ile Ser Val Thr Leu Lys Arg Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Val  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Arg Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Ala Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Asn Cys  Glu Glu Arg Asn Leu  His Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Gly Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Val Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Pro Arg Leu Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  His Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln His  Pro Pro Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Glu Leu Leu Gly Val  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Lys Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Glu  Val Leu Gln 
    1550                 1555                 1560             


Gln Val  Arg Glu Ile Arg Tyr  Arg Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Val  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Met Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Thr 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Arg  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Tyr Glu  Lys Val His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ser Leu Ala  Gly Pro Lys Ala Gly  Ser Asn Val 
    1835                 1840                 1845             


Val Arg  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Ala Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Gly  Gln Pro Pro Leu Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Gln Leu Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asp Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Thr  Ile Met Tyr Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Ile Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Ala Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Lys Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Glu  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Met Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Leu Tyr  Ala His Leu Cys Arg  Thr Lys Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Arg  Thr Asn Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg Leu Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Ala His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Glu Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Met Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Asp  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Phe Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Leu Glu Asp Ser Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Asn Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ile Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser His Trp Lys  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Asp  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Leu Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Met Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Ile Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  33
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  33

Met Phe Pro Ala Arg Pro Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ile Leu Cys Ala Lys Glu Thr Val Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Gly Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Met Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Leu Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Leu Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Thr His Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Ile Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Gln Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Glu Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Leu Arg Cys Pro Cys Val Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Gln Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Thr Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Val Lys Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Val Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Val Cys Gln Tyr Leu Leu Ala Gln 
                405                 410                 415     


Asp Cys Gln Asp His Thr Phe Ser Val Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Arg Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ser Met Asp Gly Gln Asp Val Gln Ile Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Met Leu 
            500                 505                 510         


Ser Pro Ile Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Arg Gly Asp Asp Phe Val Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Glu 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Gln Ser Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His Arg Val Val Ser Pro Leu Pro Tyr Val Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Lys Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Met Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Asp Cys Asn Glu Ile Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Ala Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Thr Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Phe 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Gln Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Ala Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Ile Thr Ile Leu 
        915                 920                 925             


Val Gly Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Met 
    930                 935                 940                 


Lys Pro Met Met Asp Glu Thr His Phe Glu Val Val Glu Ser Gly His 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Ile Trp Asp His 
                965                 970                 975     


Arg Leu Ser Ile Ser Val Ala Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Thr Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Arg  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Ser Asn Val  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Arg Leu Val  Asp Pro Asp Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Ala Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  His Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Pro Lys Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Ile Thr Leu Asn  Pro Asn Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Arg Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Gly  Pro Val Arg Ala Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gln  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Glu 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Leu Ala Arg  Asn Leu Ile 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Met Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  His Thr Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Lys Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln His  Pro Pro Met 
    1460                 1465                 1470             


Val Pro  Val Thr Val Gly Pro  Gly Leu Met Gly Val  Ser Ser Ser 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Pro Thr  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Lys Ser Arg 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Arg Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Ile Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Glu  Val Leu Gln 
    1550                 1555                 1560             


Gln Val  Arg Glu Ile Arg Tyr  Arg Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Met Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Leu Pro Glu 
    1625                 1630                 1635             


Leu Glu  Gln Leu Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Gly  Val Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Asp Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Thr 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Leu Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Gln Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Tyr Glu  Lys Val His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly Pro Ser Arg Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Val Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Val  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Ile Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Lys Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Leu Gly Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Glu Gly Asn  Glu Lys Arg Pro Gly  Asp Ile Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Pro Pro Leu Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ile Pro  Glu Thr Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Gln Leu Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asp Ile Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Thr  Ile Met Tyr Glu Met  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Val Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Lys Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Leu Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Gln Leu Leu Ala  Pro Ala Thr Phe Tyr  Ala Met Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Ala Ile Ala 
    2165                 2170                 2175             


Leu Tyr  Ala His Leu Cys Arg  Thr Lys Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Arg  Ser Asn Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg Leu Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Ser His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Ser  Ala Glu Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Ser  Ser Cys Asp Val Pro  Leu Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Met Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Asp  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Phe Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Asn Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Asp Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Thr Ala Cys Glu  Val Val Thr Gly Ser  Leu Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser His Trp Arg  Asn Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Asp  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Ile Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Ala Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Leu Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Ile Gln Val Gly  Pro Val Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Val Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Thr 
    2645                 2650                 2655             


Met Met  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Thr Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asn Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Ala  Ser Lys Ala Leu Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Met Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu Arg Cys Thr Asn  Gly Ser Leu 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  34
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  34

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Arg Thr Arg Gly Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asn Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ser Ser Ser Gly Glu Met Gln Lys Ala Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Thr Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  35
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  35

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Arg Thr Arg Gly Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asn Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ser Ser Ser Gly Glu Met Gln Lys Ala Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Thr Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Ala Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Ile  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Phe  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ile Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Arg Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  36
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  36

Met Asn Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Trp Pro Gly Thr Leu Cys Thr Glu Lys Thr Arg Gly Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Thr Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Leu Gly Asn Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ala Asn Gly Thr Val Met Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ser Ser Ser Gly Glu Met Gln Lys Ala Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Pro Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Gln Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Asp Arg Cys Val Gln Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Arg Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Asp Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Leu Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Asp Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Ser His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Gln Val Val Ala Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Val  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Asn  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Thr Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Leu Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Ser Pro  Gly Leu Leu Gly Ile  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Phe  Ile Arg Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Leu Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Val Thr Ser Gln Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Ala  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ile Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Ser Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Leu 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Leu Cys  Thr Thr Cys Arg Cys  Thr Val Gln Val Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Arg Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Glu Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  37
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  37

Met Asn Pro Phe Arg Tyr Glu Ile Cys Leu Leu Val Leu Ala Leu Thr 
1               5                   10                  15      


Trp Pro Gly Thr Leu Cys Thr Glu Lys Pro Arg Asp Arg Pro Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Thr Met Tyr Ser Phe Ala Gly Gly Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Leu Gly Asn Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ala Asn Gly Thr Val Met Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Arg Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Phe Gly Phe Ala Ala Arg Ile Asp Gly Asp Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Met Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Glu Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Asn Cys Asn Ser Ser Ser Gly Asp Met Gln Gln Ala Met Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Thr Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Thr Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Pro Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Gln Gln Cys Val Asp Gly Cys Gly Cys Pro Glu Gly Glu Leu 
                325                 330                 335     


Leu Asp Glu Asp Arg Cys Val Gln Ser Ser Asp Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Met Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Ser Val Arg Leu 
        435                 440                 445             


Ser Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Ile Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ser Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu Gln Gly Asp Cys Pro 
545                 550                 555                 560 


Asp Leu His Arg Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Ser Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Asp Phe Cys Ala Leu Gly Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Asn Ser Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Leu Pro Asp Glu Glu Cys Ser Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Leu Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Thr Pro Gly Ser Leu Leu Pro Asp Ile Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Gln 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Leu Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Lys Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Glu Glu Tyr Ala Pro Gly Asp Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Arg Trp Asn Cys Thr Asn His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Asp Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Leu Lys Asp Glu Ser His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Gln Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys His Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Leu Ser 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Gly  Cys Asn Arg Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Gln Val Val Ala Trp  Arg Thr Pro Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Val  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Arg Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Ser  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Asn Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asn Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Leu Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Ile Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Leu Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala His  Ile Thr Val Ser Pro  Gly Ile Ala Gly Ile  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Glu Val Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Leu Glu Glu Val Ile  Gln Arg Met Asp Val  Ser Pro Asp 
    1520                 1525                 1530             


Gly Thr  His Ile Ser Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Asn Glu Ala  Gln Ser Lys Glu Asp  Val Leu Arg 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Gln  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Pro Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Met Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Ser Arg Pro  Ile Ala Pro Ile Phe  Ile Arg Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Thr 
    1655                 1660                 1665             


Cys Cys  Ser Lys Glu Gly Leu  Gln Leu Pro Thr Leu  Pro Pro Leu 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Leu Pro Glu Ser  Ser Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Ile Gln Tyr  Gly Ser Ile Asn Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Gln  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Val Thr Ser Gln Ile  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Ile Ile  Met Asp Thr 
    1790                 1795                 1800             


Ser Leu  Asp Ser Val Asp Thr  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Ala Val Phe Pro Ile  Gly Val Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Gln Val Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Ser Gly Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Ala Asn Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  His Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Ser Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Asn Cys Ser Tyr Val  Ile Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Lys 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Ala  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Met Ala Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Leu  Ala Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Thr His Leu  Gly His Ile 
    2045                 2050                 2055             


Leu Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Thr Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Tyr Thr Cys Gln Ala  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Ser Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Ile Ala  Pro Ala Thr Phe His  Thr Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Phe Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Gln His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ile Asn  Cys Thr Ala Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Lys 
    2300                 2305                 2310             


Gln Ser  Ala Asn Leu Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Asn Cys Asn Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Thr Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Leu 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Val Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Thr  Cys Thr Cys Thr Asp  Met Glu Asp Thr Val  Val Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Gln 
    2465                 2470                 2475             


Pro Gly  Phe Ser Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Lys  Val Val Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  His Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Val 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Glu Asp 
    2525                 2530                 2535             


Ala Val  Phe Val Gln Gln Arg  Asn Ile Ser Cys Pro  Gln Leu Ala 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Asn Cys  Glu Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys His  Cys Glu Pro Val Glu  Ala Cys Leu 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Leu Cys  Thr Thr Cys Arg Cys  Ile Val Gln Thr Gly  Ala Ile Ser 
    2600                 2605                 2610             


Arg Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Met Gly  Tyr Arg Glu Glu Lys  Ser Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Arg Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Gln Asp Glu  Thr Phe Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Leu  Cys Arg Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Val Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Lys  Val Gln Tyr 
    2720                 2725                 2730             


Ile Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Glu Gln  Cys Ser Cys Cys Trp  Pro Ser Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Ile Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Asn  Cys Ser Lys 
    2810             


<210>  38
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  38

Met Asn Pro Ala Arg Phe Glu Ile Trp Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Trp Pro Gly Thr Leu Cys Thr Glu Lys Thr Arg Asp Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Thr Met Tyr Ser Phe Ala Gly Gly Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Leu Gly Asn Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ala Asn Gly Thr Val Met Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Asp Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Met Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Ala Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


His Cys Asn Ser Ser Ser Gly Asp Met Gln Lys Ala Met Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Thr Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys His Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Pro Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Gln Gln Cys Val Asp Gly Cys Gly Cys Pro Glu Gly Glu Leu 
                325                 330                 335     


Leu Asp Glu Asp Arg Cys Val Gln Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Met Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Ser Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Ile Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ser Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu Gln Gly Asp Cys Pro 
545                 550                 555                 560 


Asp Leu His Arg Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Asp Phe Cys Ala Leu Gly Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Asn Ser Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Leu Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Thr Pro Gly Ser Leu Leu Pro Asp Ile Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Gln 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Leu Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Lys Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Gln Glu Tyr Ala Pro Gly Asp Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Arg Trp Asn Cys Thr Asn His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Ile Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Leu Lys Asp Glu Ser His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Gln Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ser Val Ser Val Val Leu Lys His Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Leu Ser 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Gly  Cys Asn Arg Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Gln Val Val Ala Trp  Arg Thr Pro Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Val  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Arg Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Ser  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Asn Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Ser Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Leu Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Arg  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Ile Thr Thr Ser Pro  Gly Ile Leu Gly Ile  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Glu Val Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Leu Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Ile Ser Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Asn Glu Ala  Gln Ser Lys Glu Asp  Val Leu Arg 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  His Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Gln  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Pro Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Ala Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Phe  Ile Arg Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Arg Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Thr 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Leu Pro Glu Ser  Tyr Phe Asp Met Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Asn Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Val Thr Ser Gln Ile  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Ile  Met Asp Thr 
    1790                 1795                 1800             


Ser Leu  Asp Ser Val Asp Thr  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Ala Val Phe Pro Ile  Gly Val Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Gln Val Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Ser Gly Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asn Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  His Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Ser Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Asn Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Ala  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Met Ala Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Ala Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Leu Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  His Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe His  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Gln His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Val Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ala Asn  Cys Thr Ala Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Lys 
    2300                 2305                 2310             


Glu Ser  Ala Asn Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Asn Cys Asn Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Thr Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Thr  Cys Thr Cys Thr Asp  Met Glu Asp Thr Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Gln 
    2465                 2470                 2475             


Pro Gly  Phe Ser Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Lys  Val Met Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  His Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Val 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Glu Glu 
    2525                 2530                 2535             


Ala Val  Phe Val Gln Gln Arg  Asn Ile Ser Cys Pro  Gln Leu Ala 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Glu Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Leu 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Leu Cys  Thr Thr Cys Arg Cys  Ile Val Gln Thr Gly  Ala Ile Ser 
    2600                 2605                 2610             


Arg Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Met Gly  Tyr Arg Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Lys  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Glu Gln  Cys Ser Cys Cys Trp  Pro Ser Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Ile Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  39
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  39

Met Asn Pro Ala Arg Phe Glu Ile Trp Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Trp Pro Gly Thr Leu Cys Thr Glu Lys Thr Arg Asp Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Thr Met Tyr Ser Phe Ala Gly Gly Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Leu Gly Asn Phe Gln Asp Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Ala Asn Gly Thr Val Met Gln Gly Asp Gln Ser Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Asp Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Met Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Met Gln 
                165                 170                 175     


Glu Gly Ala Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


His Cys Asn Ser Ser Ser Gly Asp Met Gln Lys Ala Met Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Thr Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys His Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu Pro Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Gln Gln Cys Val Asp Gly Cys Gly Cys Pro Glu Gly Glu Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Gln Ser Ser Glu Cys Ser Cys Val His 
            340                 345                 350         


Ala Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Met Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Ser Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Ile Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ser Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu Gln Gly Asp Cys Pro 
545                 550                 555                 560 


Asp Leu His Arg Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ala Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Asn Tyr Ala Ala Ala Cys Ala Arg Lys Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Asp Phe Cys Ala Leu Gly Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Asn Ser Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Asp Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Leu Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Thr Pro Gly Ser Leu Leu Pro Asp Ile Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Gln 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Leu Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Lys Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Gln Glu Tyr Ala Pro Gly Asp Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Arg Trp Asn Cys Thr Asn His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Ile Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Leu Lys Asp Glu Ser His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Gln Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ser Val Ser Val Val Leu Lys His Thr His Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Leu Ser 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Gly  Cys Asn Arg Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Gln Val Val Ala Trp  Arg Thr Pro Ala Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Val  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Arg Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Ile Thr Leu Ser  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  His Cys Gln Asn Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Ser Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Ser Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Thr Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Leu Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Arg  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Ile Thr Thr Ser Pro  Gly Ile Leu Gly Ile  Ser Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Glu Val Gly  Glu Ala Asn Phe Asn  Lys Ser Lys 
    1505                 1510                 1515             


Glu Phe  Leu Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Ile Ser Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Asn Glu Ala  Gln Ser Lys Glu Asp  Val Leu Arg 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  His Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Gln  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Pro Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Ala Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Phe  Ile Arg Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Arg Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Thr 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Gly Leu Pro Glu Ser  Tyr Phe Asp Met Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Asn Thr  Ile Asp Ile 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Val Thr Ser Gln Ile  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Ile  Met Asp Thr 
    1790                 1795                 1800             


Ser Leu  Asp Ser Val Asp Thr  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Ala Val Phe Pro Ile  Gly Val Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Gln Val Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Ser Gly Val 
    1865                 1870                 1875             


Cys Val  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asn Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  His Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Ser Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Asn Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Met 
    1985                 1990                 1995             


Gln Ala  Cys Met Lys Ser Ile  Glu Val Lys His Ala  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Met Ala Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Ala Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Leu Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  His Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe His  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Gln His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Val Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ala Asn  Cys Thr Ala Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Lys 
    2300                 2305                 2310             


Glu Ser  Ala Asn Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Asn Cys Asn Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Thr Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Thr  Cys Thr Cys Thr Asp  Met Glu Asp Thr Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Gln 
    2465                 2470                 2475             


Pro Gly  Phe Ser Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Lys  Val Met Ala Gly Ser  Leu Arg Gly 
    2495                 2500                 2505             


Asp Ser  His Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Val 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Glu Glu 
    2525                 2530                 2535             


Ala Val  Phe Val Gln Gln Arg  Asn Ile Ser Cys Pro  Gln Leu Ala 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Glu Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Leu 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Leu Cys  Thr Thr Cys Arg Cys  Ile Val Gln Thr Gly  Ala Ile Ser 
    2600                 2605                 2610             


Arg Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Met Gly  Tyr Arg Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Lys  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Glu Gln  Cys Ser Cys Cys Trp  Pro Ser Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Ile Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  40
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  40

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Arg Thr Arg Gly Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Asn Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asn Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Ile Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg His Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ser Ser Ser Gly Glu Met Gln Lys Ala Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Gln 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Val Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ile 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Gln Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Arg  Lys Val Thr Leu Asn  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  Arg Cys Gln Thr Cys  His Cys Asp Gly Ala  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Ala Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Val  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln His  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Glu Ile  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Arg Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Phe  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Glu Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Glu 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Val  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Arg Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Gly Cys His Arg  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Glu Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ser  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ile Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ala Cys  Pro Pro His Arg Thr  Pro Ala Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Thr 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Arg Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Gln Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Arg Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  41
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  41

Met Ala Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Phe Cys Thr Glu Arg Thr Leu Asp Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Asn Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asn Phe Gln Asn Gly Glu 
65                  70                  75                  80  


Arg Val Gly Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Val Gln Gly Asp Gln Arg Ile Ser Val Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Phe Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Ala Ala Arg Ile Asp Ser Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ser Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ser Ser Ser Gly Glu Met Gln Lys Ala Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Ser Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Leu Ala Cys Val Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Val Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Ala Gly His Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asp Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Gln 
                405                 410                 415     


Asp Cys Gln Asp His Thr Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Ala Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Val Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Arg Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Leu Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Ala 
    530                 535                 540                 


Leu Val Ala Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Met Gln Pro Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Ala Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Ala Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Phe Cys Arg 
        755                 760                 765             


Ala Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Val Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Asp Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Phe Ala Pro Gly Glu Thr Val Lys Val Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Gly Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Gly His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Thr Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Phe Phe Ile Leu Leu Leu Gly Arg Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


Arg Leu Val Ile Ser Val Val Leu Lys Gln Thr Phe Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asn Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Ser  Lys Val Val 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Met 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Ala  Cys Ala Gln 
    1100                 1105                 1110             


Gln Gly  Lys Val Val Ser Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Asp Ser Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Arg Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro His Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Arg  Lys Val Thr Leu Asn  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  Arg Cys Gln Thr Cys  His Cys Asp Gly Ala  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Ala Thr  Thr Pro Tyr Leu Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Leu  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Asp Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Thr Phe Val  Val Ser Val Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Leu Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Val  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Ser Glu Pro  Lys Gln Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Ser  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Leu Met Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Gln Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp His  Ala Pro Glu Ala Pro  Ala Pro Thr Gln His  Thr Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Ser Glu Ile  Leu Ser Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Ala Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Gln Phe  Arg Gly Gly Asn Gln  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Gly Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Gln  Arg Ile Ser Trp Pro  Ser Thr Pro Ile Phe  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Met Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Asp Thr Val  Gln Leu Pro Thr Leu  Arg Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ile Pro Ala Ser  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Thr Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Gln  Lys Glu His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Ala Ala Ser Lys Val  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Gln Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Pro 
    1820                 1825                 1830             


Gly Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Val Glu  Asp Leu Pro Thr Val  Val Ser Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Val Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu His Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  Gln Val Pro 
    1910                 1915                 1920             


Arg Pro  Leu Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Lys Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ser Ser 
    1985                 1990                 1995             


Pro Thr  Cys Met Lys Ser Ile  Glu Val Lys His Glu  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Val Pro Tyr Ile Gly  Arg Asn Met Glu Val  Ser Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Gly Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asn  Gly Ser Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Leu  Cys Pro Val 
    2120                 2125                 2130             


Ser Gly  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Val Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ser  Pro Ala Thr Phe Tyr  Thr Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Gly Cys His Gln  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Glu Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Gln Gln Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Thr  Ser Cys Gly Glu His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Arg Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Glu Cys Val Gly Glu  Asp Gly Ala Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ser  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ile Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Ser  Gly Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Ile Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Ala  Ser Pro Pro 
    2360                 2365                 2370             


Ala Cys  Pro Pro His Arg Thr  Pro Ala Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


His Gly  Thr Val Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Thr Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Leu Arg Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gly Ser Phe Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asp Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Pro Gly  Phe Gln Pro Ser Cys  Arg Thr Val 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys His  Cys Glu Pro Met Glu  Ala Cys Val 
    2570                 2575                 2580             


Val Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Arg Ala Gly  Ala Val Ser 
    2600                 2605                 2610             


Gly Phe  Glu Leu Glu Cys Arg  Lys Thr Thr Cys Gln  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Arg Glu Glu Lys  Asn His Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Glu Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Met Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Arg  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Ala Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Ile Lys  Val Gly Asp Cys Thr  Ser Gln Glu Lys Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Thr  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Ala Leu 
    2765                 2770                 2775             


Thr Glu  Pro Met Trp Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val His  His Gln Val Leu Asn  Ala Arg Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Gly Lys 
    2810             


<210>  42
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  42

Met Ala Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Phe Cys Thr Glu Arg Thr Leu Asp Arg Pro Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Asn Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asn Phe Gln Asn Gly Glu 
65                  70                  75                  80  


Arg Val Gly Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Val Gln Gly Asp Gln Arg Ile Ser Val Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Phe Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Ala Ala Arg Ile Asp Ser Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asp Phe Asn Ile Phe Ser Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Gln Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ser Ser Ser Gly Glu Met Gln Glu Ala Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Ser Leu Cys Thr 
                245                 250                 255     


Cys Thr Gln Gly Leu Ala Cys Val Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Val Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Ala Gly His Cys Val Asp Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asp Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Gln 
                405                 410                 415     


Asp Cys Gln Asp His Thr Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Ala Ala Leu His Asp Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Val Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Arg Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Leu Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Ala 
    530                 535                 540                 


Leu Val Ala Asp Phe Gly Asn Ser Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Met Gln Pro Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Ala Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Pro Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Gln Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val His Ile 
625                 630                 635                 640 


Gly Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser His Pro Asp Glu Glu Cys Ser Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Gln Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Ala Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Ala Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Gly Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Phe Cys Arg 
        755                 760                 765             


Ala Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Val Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Asp Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Phe Ala Pro Gly Glu Thr Val Lys Val Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Gly Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Gly His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Thr Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Lys Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Phe Phe Ile Leu Leu Leu Gly Arg Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


Arg Leu Val Val Ser Val Val Leu Lys Gln Thr Phe Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asn Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Pro Gln  Cys Ala Asp Thr Ser  Lys Val Val 
    1025                 1030                 1035             


Leu Asp  Val Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Met 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Ala  Cys Ala Gln 
    1100                 1105                 1110             


Gln Gly  Lys Val Val Ser Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Asp Ser Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Arg Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro His Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Arg  Lys Val Thr Leu Asn  Pro Asp Asp 
    1205                 1210                 1215             


Pro Ala  Arg Cys Gln Ala Cys  His Cys Asp Gly Ala  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Ala Thr  Thr Pro Tyr Leu Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Leu  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Asp Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Thr Phe Val  Val Ser Val Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Leu Glu  Leu Lys Ala Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Val  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Glu Arg Pro  Glu Ala Ser Arg Ile  Val Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Ser Glu Pro  Lys Gln Met Thr Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Ser  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Leu Met Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Gln Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp His  Ala Pro Glu Ala Pro  Ala Pro Thr Gln His  Thr Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Arg Leu Ser Glu Ile  Leu Ser Pro 
    1475                 1480                 1485             


Glu Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Ala Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Arg Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Gln Phe  Arg Gly Gly Asn Gln  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Gly Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Gln  Arg Val Ser Trp Pro  Ser Thr Pro Ile Phe  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Arg Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Asp Thr Val  Gln Leu Pro Thr Leu  Arg Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ile Pro Ala Ser  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Thr Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Gln  Lys Glu His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly His Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Ala  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Ala Ala Ser Lys Val  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Gln Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Pro 
    1820                 1825                 1830             


Gly Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Val Glu  Asp Leu Pro Thr Val  Val Ser Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Val Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu His Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  Gln Val Pro 
    1910                 1915                 1920             


Lys Pro  Leu Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Lys Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ser Ser 
    1985                 1990                 1995             


Pro Thr  Cys Met Lys Ser Ile  Glu Val Lys His Glu  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Pro  Val Pro Tyr Ile Gly  Arg Asn Met Glu Val  Ser Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met Tyr Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Gly Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asn  Gly Ser Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Leu  Cys Pro Val 
    2120                 2125                 2130             


Ser Gly  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Val Phe Ser 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ser  Pro Asp Thr Phe Tyr  Thr Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Gly Cys His Gln  Glu Arg Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Ala Glu Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Gln Gln Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Thr  Ser Cys Gly Glu His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Arg Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Glu Cys Val Gly Glu  Asp Gly Ala Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ser  Trp Val Pro Asp His  Gln Pro Cys His Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Arg Ile Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Ser  Gly Asn Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro Pro Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Ile Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Arg Glu  Glu Cys Arg Arg Ala  Pro Pro Pro 
    2360                 2365                 2370             


Thr Cys  Pro Pro His Arg Thr  Pro Ala Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Glu  Glu Tyr Glu Cys Ala  Cys Ser Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


His Gly  Thr Val Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Thr Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Met Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Leu Arg Ala Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Leu  Gly Ser Phe Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Leu Glu  Asp Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Pro Gly  Phe Gln Pro Ser Cys  Arg Thr Val 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys His  Cys Glu Pro Met Glu  Ala Cys Val 
    2570                 2575                 2580             


Val Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Arg Ala Gly  Ala Val Ser 
    2600                 2605                 2610             


Gly Phe  Glu Leu Glu Cys Arg  Lys Thr Thr Cys Gln  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Arg Glu Glu Lys  Ser Pro Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Glu Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Met Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Gln His Arg  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Ala Pro Asp Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Ile Lys  Val Gly Asp Cys Thr  Ser Gln Glu Lys Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Glu Gly Lys Cys Thr  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Ala Leu 
    2765                 2770                 2775             


Thr Glu  Pro Met Trp Val Pro  Leu His Cys Ala Asn  Gly Ser Val 
    2780                 2785                 2790             


Val His  His Gln Val Leu Asn  Ala Arg Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Gly Lys 
    2810             


<210>  43
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  43

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Glu Cys Ala Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Ala Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  44
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  44

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Glu Cys Leu Cys Pro Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ser Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Leu Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Thr Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Arg Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Gly Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Ala Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Ala Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  45
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  45

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Glu Cys Leu Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Gln Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Ala Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ser  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Ala Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  46
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  46

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Lys Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly His Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Glu Lys His Ser Phe Ser Leu Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala His Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Asn Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Val Ser Ser Gly Glu Met Gln Gln Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Ala Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ser Gln Gly Pro Gln Cys Leu Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asp Gln Gly Asp Asp Phe Arg Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Ala Phe 
            580                 585                 590         


Ala Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ala Cys Ser Asp Gly Arg Glu Cys Leu Cys Asp 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Val Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Met Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Ser Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Val Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Gly Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Trp Arg  Asp Glu Ile Ile Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Thr Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Ala Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Arg Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Leu Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Gly 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Gly Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Thr Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asn Ala 
    1760                 1765                 1770             


Leu Asp  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Pro Val His Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Val Leu Ala  Gly Pro Ala Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Lys  Gly Ala Cys Ser Pro  Gly Ala Gly 
    1985                 1990                 1995             


Gln Ser  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Gly Leu Ser 
    2000                 2005                 2010             


Ile Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Val Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Leu Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Ser  Asp Trp Lys Ala Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Leu Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Gly  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Leu  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ala Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Pro Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Glu  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  His Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Ser Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Leu Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Ala Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Asn Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Pro Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Val Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Thr  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Leu Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  47
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  47

Met Val Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Lys Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly His Cys Ser Tyr Phe Leu Ala Gly Asp 
    50                  55                  60                  


Cys Glu Glu His Ser Phe Ser Leu Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Gly Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala His Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Asn Gly Glu Gln Arg Cys Lys Arg Ala Pro Pro Pro Ser Ser 
        195                 200                 205             


Leu Cys Asn Val Ser Ser Gly Glu Met Gln Gln Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Ala Phe Ala Arg Cys His Pro Val 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ser Gln Gly Pro Gln Cys Leu Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Glu Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Val Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Glu Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asp Gln Gly Asp Asp Phe Arg Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Arg 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Ala Phe 
            580                 585                 590         


Ala Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ala Cys Ser Asp Gly Arg Glu Cys Leu Cys Asp 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Lys Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Val Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Val Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Met Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Gly Thr Cys Ser Ala Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Ala Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Val Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Ser Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Ser Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Leu Ser Leu Ala Thr  Cys His Asn Asn Leu  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Val Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Gly Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Glu Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Gly Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Gly  Leu Met Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Thr Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Trp Arg  Asp Glu Ile Ile Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Thr Ala Ser  Pro Pro Thr Thr Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Ala Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Arg Gly Gly Asn Glu  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Leu Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Arg Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Leu Leu Pro Arg Glu  Ala Pro Glu Leu Val  Leu Gln Gly 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Leu Pro Thr Leu  Ser Pro Val 
    1670                 1675                 1680             


Ser Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Gly Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ala Val Leu Gln Tyr  Gly Ser Ile Ala Thr  Pro Asp Val 
    1730                 1735                 1740             


Pro Trp  Asp Val Ala Gln Asp  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Ser  Met Gln Arg Leu Gly  Gly His Ser Gln Ile  Gly Asn Gly 
    1760                 1765                 1770             


Leu Asp  Val Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Val Ser Lys Ala  Val Val Ile Leu Val  Thr Gly Val 
    1790                 1795                 1800             


Ser Thr  Asp Pro Val His Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Val Leu Ala  Gly Pro Gly Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Phe His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Asn His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Lys  Gly Ala Cys Ser Pro  Gly Glu Gly 
    1985                 1990                 1995             


Gln Ser  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Gly Leu Ser 
    2000                 2005                 2010             


Ile Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Val Met His Glu Leu  Arg Phe Ser His Leu  Gly His Ile 
    2045                 2050                 2055             


Leu Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Ser  Asp Trp Lys Ala Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Leu Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Arg Val Cys Asp  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asn Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Glu His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Gly  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Leu  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ala Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asp  Ala Glu Gln Cys Cys  Pro Asp Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Pro Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Ser Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Glu  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Thr Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Pro Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Leu Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  His Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Ser Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Leu Gly  Phe Gln Leu Ser Cys  Gly Thr Ser 
    2555                 2560                 2565             


Gly Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Gln  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Ala Gly  Ala Val Pro 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Asn Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Val Gly  Tyr Lys Glu Glu Lys  Asn Pro Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Val Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Glu Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Ser Val  Thr Ser Cys Pro Pro  Phe Asp Glu His Thr  Cys Leu Ala 
    2690                 2695                 2700             


Gln Gly  Gly Lys Val Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Arg  Asp Ile Thr Ala Arg  Leu Gln Ser 
    2720                 2725                 2730             


Val Thr  Val Gly Ser Cys Arg  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Leu Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu Arg Cys Ala Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Arg  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Gln 
    2810             


<210>  48
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  48

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Arg Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Glu Cys Leu Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Ser Ala Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg His Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Ala Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ala Gly Leu Ala Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Ser 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ala Ala Cys Ala Arg Arg Gly Val His Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Glu Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Ala Pro Gly Ser Leu Leu Pro Asp Thr Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Thr Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Gln Glu Pro  Gln Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Gln Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Ala Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Val Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Ser Ala Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Thr  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Ser  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Val Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Ala Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Thr Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Thr Val Gln Ala Gly  Ala Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Asn Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu Arg Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  49
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  49

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Thr Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Ser Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Ile Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  50
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  50

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Lys Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Val Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Ser Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Thr Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Ser Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Lys Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ala Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Met Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Ala Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys His Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Leu  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Ser Pro Glu Asp  Cys Pro Val Cys Glu  Ala Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Glu Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ser Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Ala Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Ser 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Lys Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Leu Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asn  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Ile Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Ala Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Gly  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asn  Ser Ser Gln Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  Pro Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ala Asn  Cys Thr Met Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Glu  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Val Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Pro  Arg Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Met Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Ala Cys  Thr Thr Cys Arg Cys  Ile Val Gln Val Gly  Ile Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Ile Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Arg Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Glu  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  51
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  51

Met Ile Pro Ala Arg Leu Ala Gly Val Leu Leu Ala Leu Ala Leu Val 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Lys Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Val Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Val Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Ser Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Thr Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Ser Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Ala Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Lys Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ala Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Met Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Ala Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys His Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Leu  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Ser Pro Glu Asp  Cys Pro Val Cys Glu  Ala Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Glu Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ser Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Ala Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Ser 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Lys Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ala  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Leu Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ala Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asn  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Arg Arg Pro Gly  Asp Ile Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Ala Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Gly  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asn  Ser Ser Gln Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  Pro Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ala Asn  Cys Thr Met Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Glu  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Val Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Pro  Arg Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Met Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Ala Cys  Thr Thr Cys Arg Cys  Ile Val Gln Val Gly  Ile Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Ile Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Arg Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Glu  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  52
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  52

Met Ile Pro Ala Arg Leu Ala Gly Val Leu Leu Ala Leu Ala Leu Val 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Lys Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Val Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Val Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Ser Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Thr Cys Pro Ala Phe Leu Glu Tyr Thr 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Ser Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Ala Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Lys Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ala Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Met Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Leu His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Ala Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys His Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Ile Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Leu  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Phe  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Ser Pro Glu Asp  Cys Pro Val Cys Glu  Ala Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Glu Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ser Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro Asp Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Thr  Val Ala Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Ser 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Lys Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ala  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ala Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asn  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Arg Arg Pro Gly  Asp Ile Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Glu Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Ala Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ala  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asn  Ser Ser Gln Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  Pro Cys Glu Arg Gly  Cys Pro Arg His Cys  Asn Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Ala Asn  Cys Thr Met Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Glu  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Val Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Pro  Arg Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Met Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Ala Cys  Thr Thr Cys Arg Cys  Ile Val Gln Val Gly  Ile Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Ile Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Val Cys Thr  Ile Arg Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Ser  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Glu  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  53
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  53

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Thr Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Ser Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Met 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Glu Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  54
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  54

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Thr Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Met 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Glu Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  55
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  55

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Met 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  56
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  56

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asp  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  57
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  57

Met Ile Pro Ala Arg Phe Ala Gly Val Leu Leu Ala Leu Ala Leu Ile 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asn Asp Phe Val Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Gly 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Ala Gly Gly Leu Glu Cys Ala Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Ala Arg Thr Cys Gln Ser Leu His Ile Asn Glu Met 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ala Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Arg Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Arg Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Ala Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Ser Val 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Ala Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Leu Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Gly Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Leu Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Lys 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Lys Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Val Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Gln Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asp Pro Lys Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Phe Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Val  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Ser 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Phe  Tyr Cys Ser Arg Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Ser  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Leu Pro  Pro His Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Leu  Gly Leu Leu Gly Leu  Ser Thr Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Asn Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Arg Tyr Leu  Ser Asp His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro Asn Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Ser Asp  Cys Ser Gln Pro Leu  Asp Val Ile Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Phe Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  Arg Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Val Pro Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Met  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Gly Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Leu 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Arg 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Leu Val 
    2120                 2125                 2130             


Pro Asn  Ser Ser His Cys Gln  Val Leu Leu Leu Pro  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Gln  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asp  Lys Val Met Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Arg Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Lys Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Leu  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Ser  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Val Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Gln  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Ile Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Val Cys Pro Ser Gly  Phe Gln Leu Asn Cys  Lys Thr Ser 
    2555                 2560                 2565             


Ala Cys  Cys Pro Ser Cys Arg  Cys Glu Arg Met Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Val Ile Gly  Pro Gly Lys Thr Val  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys Arg Cys  Met Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Asn  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Thr Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Thr 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Phe  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Asn  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Asn  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Ala  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Glu Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  58
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  58

Met Ile Pro Ala Arg Phe Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ile Leu Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Gly 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Thr Glu Gly Leu Glu Cys Val Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asn His 
        275                 280                 285             


Gly Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Met His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Lys Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Thr Ser Val His Val Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ser Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Ser Glu Asp Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Glu Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Met Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Ser Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys Arg Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ala 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Thr 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Met  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Thr Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Ser Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Val Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Met  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Val Ser 
    1250                 1255                 1260             


Glu Ala  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ile Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Met Pro  Pro His Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Leu 
    1475                 1480                 1485             


Gly Pro  Lys Arg Lys Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Thr Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln His Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ala Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Lys Leu Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Met Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asn Ala 
    1760                 1765                 1770             


Leu Asp  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Gly Ala  Ala Ala Asp Ala Ala  Arg Ala Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Ala Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Ser  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Ser Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser Gln Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Ser  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Lys Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Ala Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Met Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Glu Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Phe  Leu Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Arg Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Leu Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Phe Cys Pro Pro Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Arg Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Ala Cys His Cys  Ile Val Glu Ala Gly  Ala Ala Ser 
    2600                 2605                 2610             


Gly Phe  Gln Leu Glu Cys Arg  Lys Thr Thr Cys Lys  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Pro Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Ser  Cys Lys Val Asn Glu  Ile Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Ala Ser Cys Pro Pro  Phe Asp Glu His Glu  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Thr Pro Gly Thr Cys  Cys Asp Arg 
    2705                 2710                 2715             


Cys Glu  Val Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  59
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  59

Met Ile Pro Ala Arg Phe Ala Arg Val Leu Leu Ala Leu Ala Leu Thr 
1               5                   10                  15      


Leu Pro Gly Ile Val Cys Ala Glu Gly Thr Arg Gly Arg Ser Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Ser Asp Phe Ile Asn Thr Phe Asp Gly 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Tyr Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys Arg Ser Phe Ser Ile Ile Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Leu 
                85                  90                  95      


Phe Val Asn Gly Thr Val Thr Gln Gly Asp Gln Arg Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Lys Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Gly Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Ile Phe Ala Glu Asp Asp Phe Met Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Trp Cys Glu Arg Ala Ser Pro Pro Ser Gly 
        195                 200                 205             


Ser Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Thr Ser Val Phe Ala Arg Cys His Pro Leu 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Glu 
                245                 250                 255     


Cys Thr Glu Gly Leu Glu Cys Val Cys Pro Ala Phe Leu Glu Tyr Ala 
            260                 265                 270         


Arg Thr Cys Ala Gln Glu Gly Met Val Leu Tyr Gly Trp Thr Asn His 
        275                 280                 285             


Gly Ala Cys Ser Pro Val Cys Pro Ala Gly Met Glu Tyr Lys Gln Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Arg Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Leu Cys Val Glu Ser Thr Glu Cys Pro Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Thr Ser Leu Ser Arg Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Gln Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Lys Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Phe Val Thr Val Arg Leu 
        435                 440                 445             


Pro Gly Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Leu Leu Lys Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln His Thr Val Thr Thr Ser Val His Val Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ser Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Gln Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Ala Glu Pro 
    530                 535                 540                 


Arg Val Glu Asp Phe Gly Asn Ala Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln His Ser Asp Pro Cys Ala Leu Asn Pro Arg Met 
                565                 570                 575     


Thr Arg Phe Ser Glu Glu Ala Cys Ala Val Leu Thr Ser Pro Thr Phe 
            580                 585                 590         


Glu Ala Cys His Arg Ala Val Ser Pro Leu Pro Tyr Leu Arg Asn Cys 
        595                 600                 605             


Arg Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Glu Cys Leu Cys Gly 
    610                 615                 620                 


Ala Leu Ala Ser Tyr Ala Ala Ala Cys Ala Gly Arg Gly Val Arg Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Arg Cys Glu Leu Asn Cys Pro Lys Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Ser Glu Asp Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Met Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Ile Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Glu Val Pro Gly Ser Leu Leu Pro Asp Ala Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Gly His Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Thr Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Val Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser His Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Ile Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp Arg 
                965                 970                 975     


His Leu Ser Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Leu Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Ser Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Ser Ser Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys Arg Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ala 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Thr 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Met  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Thr Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Ser Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Arg Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asn Pro Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Ala Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Glu  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Met  Pro Pro Thr 
    1235                 1240                 1245             


Asp Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Val Ser 
    1250                 1255                 1260             


Glu Ala  Pro Leu His Asp Phe  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Val Phe  Leu Leu Asp Gly Ser  Ser Arg Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Ala Phe Val  Val Asp Met Met Glu  Arg Leu Arg 
    1295                 1300                 1305             


Ile Ser  Gln Lys Trp Val Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ala Tyr Ile Gly  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Ser  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ile Asp Arg Pro  Glu Ala Ser Arg Ile  Ile Leu Leu 
    1370                 1375                 1380             


Leu Met  Ala Ser Gln Glu Pro  Gln Arg Met Ser Arg  Asn Phe Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Asn Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Gly Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Gln Arg  Asp Glu Ile Val Ser  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Pro Pro Thr Met Pro  Pro Asn Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Met Gly Pro  Gly Leu Leu Gly Val  Ser Pro Leu 
    1475                 1480                 1485             


Gly His  Lys Arg Lys Ser Met  Val Leu Asp Val Ala  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Ile Gly  Glu Ala Asp Phe Asn  Arg Thr Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Gly Ile  His Val Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Pro Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


Arg Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln His Leu  Ser Glu His Ser Phe  Leu Val Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Gly Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Gln Ile Pro Thr Leu  Ala Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Ser Pro Ala Ser  Tyr Phe Asp Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Lys Leu Gly Pro  His Leu Thr 
    1715                 1720                 1725             


Arg Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Met Glu  Lys Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Val  Met Gln Arg Glu Gly  Gly Pro Ser Gln Ile  Gly Asn Ala 
    1760                 1765                 1770             


Leu Asp  Phe Ala Val Arg Tyr  Leu Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Thr Asp Val 
    1790                 1795                 1800             


Ser Val  Asp Ser Val Gly Ala  Ala Ala Asp Ala Ala  Arg Ala Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Ala 
    1820                 1825                 1830             


Ala Gln  Leu Arg Ile Leu Ala  Gly Pro Ala Ala Asp  Ser Asn Val 
    1835                 1840                 1845             


Val Ser  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Gly Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Ile 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Gln  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Arg Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Val Lys  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Thr Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Gly  Cys Met Lys Ser Ile  Glu Val Lys His Ser  Ala Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Ala Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Val Gly  Gly Asn Met Glu Val  Ser Ile Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Val  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Thr Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Trp Lys Thr Leu  Val Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Ser Gly  Gln Thr Cys Gln Pro  Ile Leu Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Asp  Ser Ser Gln Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Ser Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Pro Asp Phe Cys Ala  Met Ser Cys Pro Ser  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu Arg Gly  Cys Pro Arg His Cys  Asp Gly Asn 
    2210                 2215                 2220             


Val Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro Asn  Gln Val Met Leu Glu  Gly Ser Cys Val Pro  Lys Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Gly Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Ala  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Thr Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Thr Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Lys  Ala Pro Thr Cys Gly  Leu Cys Glu Val Ala  Arg Leu Arg 
    2300                 2305                 2310             


Gln Asn  Ala Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Pro Val  Ser Cys Asp Leu Pro  Ala Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Met Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Glu Arg Val  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Phe  Leu Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Thr Ala Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Ser Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Arg Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Ser Trp Lys  Ser Val Gly Ser Arg  Trp Ala Ser 
    2510                 2515                 2520             


Leu Glu  Asn Pro Cys Leu Ile  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Glu 
    2540                 2545                 2550             


Val Pro  Phe Cys Pro Pro Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Arg Cys Arg  Cys Glu Pro Val Glu  Ala Cys Met 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Val  Met Val Asp 
    2585                 2590                 2595             


Val Cys  Thr Ala Cys His Cys  Ile Val Glu Ala Gly  Ala Ala Ser 
    2600                 2605                 2610             


Gly Phe  Gln Leu Glu Cys Arg  Lys Thr Thr Cys Lys  Pro Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Asn  Asn Pro Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Thr Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Lys Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Ser  Cys Lys Val Asn Glu  Ile Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Ala Ser Cys Pro Pro  Phe Asp Glu His Glu  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Thr Pro Gly Thr Cys  Cys Asp Arg 
    2705                 2710                 2715             


Cys Glu  Val Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Ser Cys Lys  Ser Glu Val Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Met Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Ile Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  60
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  60

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Val Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Leu Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Arg Phe Ala Glu Asp Asp Phe Val Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Ser 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Asp Cys Pro Cys Ser Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala His Gln Gly Val Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Thr Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Arg Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ser Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Leu Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln Pro Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Gln Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asn 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Val Ser Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Val Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Leu Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Leu Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Leu Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Pro Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Leu  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Leu  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Val Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Gly  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ala Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Gly Pro  Thr Arg Ser Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Ile Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Thr Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Ser Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Arg Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Ser  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His His Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  Arg Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Gly  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Val 
    1820                 1825                 1830             


Ser Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Lys Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Ile Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Gln Arg Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Gln His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Val Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Gly Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Leu  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Thr Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Met Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Gln Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  61
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  61

Met Ile Pro Ala Arg Leu Ala Arg Val Leu Leu Val Leu Val Leu Ala 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Leu Ser Met 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Ser Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Arg Phe Ala Glu Asp Asp Phe Val Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Thr Arg Cys His Pro Ser 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Asp Cys Pro Cys Ser Ala Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala His Gln Gly Val Val Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Thr Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Arg Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ser Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Leu Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Ile 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln Pro Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gly Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Gln Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asn 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Val Ser Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Gly Phe Cys Ala Leu Ser Cys Pro Gln Asp Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Asp Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Val Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Leu Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Leu Gln Asp 
                885                 890                 895     


Tyr Cys Gly Ser Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Ile Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Ser Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Arg Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Ile Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Ala  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Leu Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Pro Pro Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Leu  Pro Pro Thr 
    1235                 1240                 1245             


Glu Ala  Pro Val Ser Pro Thr  Thr Pro Tyr Val Glu  Asp Ile Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Leu  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Val Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Glu  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Gly  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ala Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Pro 
    1475                 1480                 1485             


Glu Pro  Thr Arg Ser Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Ile Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Thr Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Ala Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Ser Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Arg Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Asn Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Pro  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His His Thr 
    1715                 1720                 1725             


Gln Val  Ala Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Asp  Arg Ala His Leu Leu  Asn Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Ser  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Val Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Val 
    1820                 1825                 1830             


Ser Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Ile Thr Leu 
    1850                 1855                 1860             


Asp Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Gln Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Lys Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Ile Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Gln Arg Thr Leu  Ile Gln Glu Trp Thr  Val Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Ser  Val Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Thr His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Ile Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Gln His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Lys Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val Gln His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Val Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Gly Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Leu  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Glu  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Thr Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Met Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Gln Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Thr Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Ile Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Val Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  62
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  62

Met Ile Pro Ala Gln Leu Ala Arg Val Leu Leu Val Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Leu Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Arg Phe Ala Glu Asp Asp Phe Val Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Ser 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Lys Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Asp Cys Pro Cys Ser Val Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala His Gln Gly Val Arg Leu Tyr Gly Trp Thr Asp His 
        275                 280                 285             


Ser Thr Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Arg Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ser Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Leu Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Met Asp Gly Gln Asp Val Gln Leu Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln Pro Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gln Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Gln Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asn 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Val Ser Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Val Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Leu Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Leu Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Gly Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Leu Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Val 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Val  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Leu Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Pro Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Leu  Pro Pro Thr 
    1235                 1240                 1245             


Val Ala  Pro Val Ser Ala Thr  Thr Pro Tyr Val Glu  Asp Ile Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Leu  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Glu Val  Leu Lys Val Phe Val  Val Gly Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Asp  Leu Lys Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Gly  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ala Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Met 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Leu 
    1475                 1480                 1485             


Gly Pro  Thr Arg Ser Ser Met  Val Leu Asp Val Val  Phe Val Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Ile Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Thr Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Ser Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Glu Gly Leu  Arg Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Ser  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His His Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  His Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Ser  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Val 
    1820                 1825                 1830             


Ser Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Lys Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Ile Gly  Gly Asn Met Glu Val  Asn Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Gln Arg Thr Phe  Ile Gln Glu Trp Thr  Met Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Ala Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Gln His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Val Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Gly Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Leu  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Thr Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Met Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Gln Arg Asp Glu  Thr Leu Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Gln Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  63
<211>  2813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC

<400>  63

Met Ile Pro Ala Gln Leu Ala Arg Val Leu Leu Val Leu Val Leu Thr 
1               5                   10                  15      


Leu Pro Gly Thr Leu Cys Thr Glu Gly Thr Arg Gly Arg Leu Ser Thr 
            20                  25                  30          


Ala Arg Cys Ser Leu Phe Gly Asp Asp Phe Ile Asn Thr Phe Asp Glu 
        35                  40                  45              


Ser Met Tyr Ser Phe Ala Gly Asp Cys Ser Tyr Leu Leu Ala Gly Asp 
    50                  55                  60                  


Cys Gln Lys His Ser Phe Ser Ile Leu Gly Asp Phe Gln Asn Gly Lys 
65                  70                  75                  80  


Arg Val Ser Leu Ser Val Tyr Leu Gly Glu Phe Phe Asp Ile His Val 
                85                  90                  95      


Phe Val Asn Gly Thr Val Met Gln Gly Asp Gln Ser Val Ser Met Pro 
            100                 105                 110         


Tyr Ala Ser Asn Gly Leu Tyr Leu Glu Thr Glu Ala Gly Tyr Tyr Lys 
        115                 120                 125             


Leu Ser Ser Glu Ala Tyr Gly Phe Val Ala Arg Ile Asp Gly Ser Gly 
    130                 135                 140                 


Asn Phe Gln Val Leu Leu Ser Asp Arg Tyr Phe Asn Lys Thr Cys Gly 
145                 150                 155                 160 


Leu Cys Gly Asn Phe Asn Arg Phe Ala Glu Asp Asp Phe Val Thr Gln 
                165                 170                 175     


Glu Gly Thr Leu Thr Ser Asp Pro Tyr Asp Phe Ala Asn Ser Trp Ala 
            180                 185                 190         


Leu Ser Ser Gly Glu Gln Arg Cys Lys Arg Ala Ser Pro Pro Ser Ser 
        195                 200                 205             


Pro Cys Asn Ile Ser Ser Gly Glu Met Gln Lys Gly Leu Trp Glu Gln 
    210                 215                 220                 


Cys Gln Leu Leu Lys Ser Ala Ser Val Phe Ala Arg Cys His Pro Ser 
225                 230                 235                 240 


Val Asp Pro Glu Pro Phe Val Ala Leu Cys Glu Ser Thr Leu Cys Thr 
                245                 250                 255     


Cys Ala Gln Gly Pro Asp Cys Pro Cys Ser Val Leu Leu Glu Tyr Ala 
            260                 265                 270         


Arg Ala Cys Ala His Gln Gly Val Arg Leu Asp Gly Trp Thr Asp His 
        275                 280                 285             


Ser Thr Cys Arg Pro Ala Cys Pro Ala Gly Met Glu Tyr Lys Glu Cys 
    290                 295                 300                 


Val Ser Pro Cys Thr Arg Thr Cys Gln Ser Leu His Ile Asn Glu Val 
305                 310                 315                 320 


Cys Gln Glu Gln Cys Val Asp Gly Cys Ser Cys Pro Glu Gly Gln Leu 
                325                 330                 335     


Leu Asp Glu Gly Arg Cys Val Glu Arg Ala Glu Cys Ser Cys Val His 
            340                 345                 350         


Ser Gly Lys Arg Tyr Pro Pro Gly Ser Ser Leu Ser Gln Asp Cys Asn 
        355                 360                 365             


Thr Cys Ile Cys Arg Asn Ser Leu Trp Ile Cys Ser Asn Glu Glu Cys 
    370                 375                 380                 


Pro Gly Glu Cys Leu Val Thr Gly Gln Ser His Phe Lys Ser Phe Asp 
385                 390                 395                 400 


Asn Arg Tyr Phe Thr Phe Ser Gly Ile Cys Gln Tyr Leu Leu Ala Arg 
                405                 410                 415     


Asp Cys Gln Asp His Ser Phe Ser Ile Val Ile Glu Thr Val Gln Cys 
            420                 425                 430         


Ala Asp Asp Pro Asp Ala Val Cys Thr Arg Ser Val Thr Val Arg Leu 
        435                 440                 445             


Pro Leu Leu His Asn Ser Leu Val Lys Leu Lys His Gly Gly Gly Val 
    450                 455                 460                 


Ala Ile Asp Gly Gln Asp Val Gln Leu Pro Phe Leu Gln Gly Asp Leu 
465                 470                 475                 480 


Arg Ile Gln Pro Thr Val Met Ala Ser Val Arg Leu Ser Tyr Gln Glu 
                485                 490                 495     


Asp Leu Gln Met Asp Trp Asp Gly Arg Gly Arg Leu Leu Val Lys Leu 
            500                 505                 510         


Ser Pro Val Tyr Ala Gly Lys Thr Cys Gly Leu Cys Gly Asn Tyr Asn 
        515                 520                 525             


Gly Asn Lys Gly Asp Asp Phe Leu Thr Pro Ser Gly Leu Val Glu Pro 
    530                 535                 540                 


Leu Val Glu Asp Phe Gly Asn Ser Trp Lys Leu His Gly Asp Cys Gln 
545                 550                 555                 560 


Asp Leu Gln Lys Gln Asp Ser Asp Pro Cys Asn Leu Asn Pro Arg Leu 
                565                 570                 575     


Thr Arg Phe Ala Glu Glu Ala Cys Ala Val Leu Thr Ser Ser Lys Phe 
            580                 585                 590         


Glu Ala Cys His His Ala Val Ser Pro Gln Pro Tyr Leu Gln Asn Cys 
        595                 600                 605             


His Tyr Asp Val Cys Ser Cys Ser Asp Gly Arg Asp Cys Leu Cys Asn 
    610                 615                 620                 


Ala Val Ala Ser Tyr Ala Ser Ala Cys Ala Arg Lys Gly Val Ser Ile 
625                 630                 635                 640 


Ala Trp Arg Glu Pro Ser Phe Cys Ala Leu Ser Cys Pro Gln Gly Gln 
                645                 650                 655     


Val Tyr Leu Gln Cys Gly Thr Pro Cys Asn Leu Thr Cys Arg Ser Leu 
            660                 665                 670         


Ser Tyr Pro Asp Glu Glu Cys Asn Glu Val Cys Leu Glu Gly Cys Phe 
        675                 680                 685             


Cys Pro Pro Gly Leu Tyr Leu Asp Glu Arg Gly Asp Cys Val Pro Lys 
    690                 695                 700                 


Ala Gln Cys Pro Cys Tyr Tyr Asp Gly Glu Ile Phe Gln Pro Glu Asp 
705                 710                 715                 720 


Val Phe Ser Asp His His Thr Met Cys Tyr Cys Glu Asp Gly Phe Met 
                725                 730                 735     


His Cys Thr Met Ser Gly Leu Pro Gly Ser Leu Leu Pro Asp Val Val 
            740                 745                 750         


Leu Ser Ser Pro Leu Ser His Arg Ser Lys Arg Ser Leu Ser Cys Arg 
        755                 760                 765             


Pro Pro Met Val Lys Leu Val Cys Pro Ala Asp Asn Pro Arg Ala Glu 
    770                 775                 780                 


Gly Leu Glu Cys Ala Lys Thr Cys Gln Asn Tyr Asp Leu Glu Cys Met 
785                 790                 795                 800 


Ser Thr Gly Cys Val Ser Gly Cys Leu Cys Pro Pro Gly Met Val Arg 
                805                 810                 815     


His Glu Asn Arg Cys Val Ala Leu Glu Arg Cys Pro Cys Phe His Gln 
            820                 825                 830         


Gly Lys Glu Tyr Ala Pro Gly Glu Thr Val Lys Ile Asp Cys Asn Thr 
        835                 840                 845             


Cys Val Cys Arg Asp Arg Lys Trp Asn Cys Thr Asp Asn Val Cys Asp 
    850                 855                 860                 


Ala Thr Cys Ser Val Ile Gly Met Ala His Tyr Leu Thr Phe Asp Gly 
865                 870                 875                 880 


Leu Lys Tyr Met Phe Pro Gly Glu Cys Gln Tyr Val Leu Leu Gln Asp 
                885                 890                 895     


Tyr Cys Gly Gly Asn Pro Gly Thr Phe Arg Ile Leu Val Gly Asn Glu 
            900                 905                 910         


Gly Cys Ser Tyr Pro Ser Val Lys Cys Lys Lys Arg Val Thr Ile Leu 
        915                 920                 925             


Val Glu Gly Gly Glu Ile Glu Leu Phe Asp Gly Glu Val Asn Val Lys 
    930                 935                 940                 


Arg Pro Met Lys Asp Glu Thr His Phe Glu Val Val Glu Ser Gly Arg 
945                 950                 955                 960 


Tyr Val Ile Leu Leu Leu Gly Lys Ala Leu Ser Val Val Trp Asp His 
                965                 970                 975     


His Leu Ala Ile Ser Val Val Leu Lys Gln Thr Tyr Gln Glu Gln Val 
            980                 985                 990         


Cys Gly Leu Cys Gly Asn Phe Asp  Gly Ile Gln Asn Asn  Asp Phe Thr 
        995                 1000                 1005             


Ser Ser  Asn Leu Gln Val Glu  Glu Asp Pro Val Asp  Phe Gly Asn 
    1010                 1015                 1020             


Ser Trp  Lys Val Asn Pro Gln  Cys Ala Asp Thr Arg  Lys Val Pro 
    1025                 1030                 1035             


Leu Asp  Ser Ser Pro Ala Thr  Cys His Asn Asn Ile  Met Lys Gln 
    1040                 1045                 1050             


Thr Met  Val Asp Ser Ser Cys  Arg Ile Leu Thr Ser  Asp Leu Phe 
    1055                 1060                 1065             


Gln Asp  Cys Asn Lys Leu Val  Asp Pro Glu Pro Tyr  Leu Asp Ala 
    1070                 1075                 1080             


Cys Ile  Tyr Asp Thr Cys Ser  Cys Glu Ser Ile Gly  Asp Cys Ala 
    1085                 1090                 1095             


Cys Phe  Cys Asp Thr Ile Ala  Ala Tyr Ala His Val  Cys Ala Gln 
    1100                 1105                 1110             


His Gly  Lys Val Val Thr Trp  Arg Thr Ala Thr Leu  Cys Pro Gln 
    1115                 1120                 1125             


Ser Cys  Glu Glu Arg Asn Leu  Arg Glu Asn Gly Tyr  Glu Cys Glu 
    1130                 1135                 1140             


Trp Arg  Tyr Asn Ser Cys Ala  Pro Ala Cys Pro Ile  Thr Cys Gln 
    1145                 1150                 1155             


His Pro  Glu Pro Leu Ala Cys  Pro Val Gln Cys Val  Glu Gly Cys 
    1160                 1165                 1170             


His Ala  His Cys Pro Pro Gly  Lys Ile Leu Asp Glu  Leu Leu Gln 
    1175                 1180                 1185             


Thr Cys  Ile Asp Leu Glu Asp  Cys Pro Val Cys Glu  Val Ala Gly 
    1190                 1195                 1200             


Arg Arg  Leu Pro Ser Gly Lys  Lys Val Thr Leu Asn  Pro Ser Asp 
    1205                 1210                 1215             


Pro Lys  His Cys Gln Ile Cys  His Cys Asp Gly Val  Asn Leu Thr 
    1220                 1225                 1230             


Cys Glu  Ala Cys Gln Glu Pro  Gly Gly Leu Val Leu  Pro Pro Thr 
    1235                 1240                 1245             


Val Ala  Pro Val Ser Ala Thr  Thr Pro Tyr Val Glu  Asp Ile Pro 
    1250                 1255                 1260             


Glu Pro  Pro Leu His Asp Leu  Tyr Cys Ser Lys Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ala Phe  Leu Leu Asp Gly Ser  Ser Lys Leu Ser Glu  Ala Glu Phe 
    1280                 1285                 1290             


Asp Val  Leu Lys Val Phe Val  Val Asp Met Met Glu  Arg Leu His 
    1295                 1300                 1305             


Ile Ser  Gln Lys Arg Ile Arg  Val Ala Val Val Glu  Tyr His Asp 
    1310                 1315                 1320             


Gly Ser  His Ser Tyr Ile Asp  Leu Arg Asp Arg Lys  Arg Pro Ser 
    1325                 1330                 1335             


Glu Leu  Arg Arg Ile Ala Gly  Gln Val Lys Tyr Ala  Gly Ser Gln 
    1340                 1345                 1350             


Val Ala  Ser Thr Ser Glu Val  Leu Lys Tyr Thr Leu  Phe Gln Ile 
    1355                 1360                 1365             


Phe Gly  Lys Ala Asp Arg Pro  Glu Ala Ser Arg Ile  Ala Leu Leu 
    1370                 1375                 1380             


Leu Thr  Ala Ser Glu Glu Pro  Pro Arg Met Ala Arg  Asn Leu Val 
    1385                 1390                 1395             


Arg Tyr  Val Gln Gly Leu Lys  Lys Lys Lys Val Ile  Val Ile Pro 
    1400                 1405                 1410             


Val Gly  Ile Gly Pro His Ala  Ser Leu Lys Gln Ile  Arg Leu Ile 
    1415                 1420                 1425             


Glu Lys  Gln Ala Pro Glu Asn  Lys Ala Phe Val Leu  Ser Ser Val 
    1430                 1435                 1440             


Asp Glu  Leu Glu Gln Arg Arg  Asp Glu Ile Ile Asn  Tyr Leu Cys 
    1445                 1450                 1455             


Asp Leu  Ala Pro Glu Ala Pro  Ala Pro Thr Gln Pro  Pro Gln Val 
    1460                 1465                 1470             


Ala Gln  Val Thr Val Gly Pro  Gly Leu Leu Gly Val  Ser Pro Leu 
    1475                 1480                 1485             


Gly Pro  Thr Arg Ser Ser Met  Val Leu Asp Val Val  Phe Leu Leu 
    1490                 1495                 1500             


Glu Gly  Ser Asp Lys Val Gly  Glu Ala Asn Phe Asn  Arg Ser Lys 
    1505                 1510                 1515             


Glu Phe  Met Glu Glu Val Ile  Gln Arg Met Asp Val  Gly Gln Asp 
    1520                 1525                 1530             


Ser Ile  His Ile Thr Val Leu  Gln Tyr Ser Tyr Met  Val Thr Val 
    1535                 1540                 1545             


Glu Tyr  Thr Phe Ser Glu Ala  Gln Ser Lys Gly Asp  Ile Leu Gln 
    1550                 1555                 1560             


His Val  Arg Glu Ile Arg Tyr  Gln Gly Gly Asn Arg  Thr Asn Thr 
    1565                 1570                 1575             


Gly Leu  Ala Leu Gln Tyr Val  Ser Glu His Ser Phe  Ser Thr Ser 
    1580                 1585                 1590             


Gln Gly  Asp Arg Glu Gln Ala  Pro Asn Leu Val Tyr  Met Val Thr 
    1595                 1600                 1605             


Gly Asn  Pro Ala Ser Asp Glu  Ile Lys Arg Leu Pro  Gly Asp Ile 
    1610                 1615                 1620             


Gln Val  Val Pro Ile Gly Val  Gly Pro His Ala Asn  Val Gln Glu 
    1625                 1630                 1635             


Leu Glu  Arg Ile Ser Trp Pro  Asn Ala Pro Ile Leu  Ile Gln Asp 
    1640                 1645                 1650             


Phe Glu  Thr Leu Pro Arg Glu  Ala Pro Asp Leu Val  Leu Gln Arg 
    1655                 1660                 1665             


Cys Cys  Ser Gly Asp Gly Leu  Arg Ile Pro Thr Leu  Ser Pro Ala 
    1670                 1675                 1680             


Pro Asp  Cys Ser Gln Pro Leu  Asp Val Val Leu Leu  Leu Asp Gly 
    1685                 1690                 1695             


Ser Ser  Ser Val Pro Ala Ser  Tyr Phe Glu Glu Met  Lys Ser Phe 
    1700                 1705                 1710             


Ala Lys  Ala Phe Ile Ser Lys  Ala Asn Ile Gly Pro  His His Thr 
    1715                 1720                 1725             


Gln Val  Ser Val Leu Gln Tyr  Gly Ser Ile Thr Thr  Ile Asp Val 
    1730                 1735                 1740             


Pro Trp  Asn Val Ala Gln Glu  His Ala His Leu Leu  Ser Leu Val 
    1745                 1750                 1755             


Asp Leu  Met Gln Gln Glu Ser  Gly Pro Ser Gln Ile  Gly Asp Ala 
    1760                 1765                 1770             


Leu Gly  Phe Ala Val Arg Tyr  Ile Thr Ser Glu Val  His Gly Ala 
    1775                 1780                 1785             


Arg Pro  Gly Ala Ser Lys Ala  Val Val Ile Leu Val  Met Asp Val 
    1790                 1795                 1800             


Ser Met  Asp Ser Val Asp Ala  Ala Ala Asp Ala Ala  Arg Ser Asn 
    1805                 1810                 1815             


Arg Val  Thr Val Phe Pro Ile  Gly Ile Gly Asp Arg  Tyr Asp Val 
    1820                 1825                 1830             


Ser Gln  Leu Arg Ile Leu Ala  Gly Pro Glu Ala Ser  Ser Asn Val 
    1835                 1840                 1845             


Val Lys  Leu Gln Arg Ile Glu  Asp Leu Pro Thr Met  Val Thr Leu 
    1850                 1855                 1860             


Asp Asn  Ser Phe Leu His Lys  Leu Cys Ser Gly Phe  Val Arg Val 
    1865                 1870                 1875             


Cys Met  Asp Glu Asp Gly Asn  Glu Lys Arg Pro Gly  Asp Val Trp 
    1880                 1885                 1890             


Thr Leu  Pro Asp Gln Cys His  Thr Val Thr Cys Leu  Pro Asp Gly 
    1895                 1900                 1905             


Gln Thr  Leu Leu Lys Ser His  Arg Val Asn Cys Asp  Arg Gly Pro 
    1910                 1915                 1920             


Lys Pro  Ser Cys Pro Asn Ser  Gln Ser Pro Ile Arg  Val Glu Glu 
    1925                 1930                 1935             


Thr Cys  Gly Cys Arg Trp Thr  Cys Pro Cys Val Cys  Met Gly Ser 
    1940                 1945                 1950             


Ser Thr  Arg His Ile Val Thr  Phe Asp Gly Gln Asn  Phe Lys Leu 
    1955                 1960                 1965             


Thr Gly  Ser Cys Ser Tyr Val  Leu Phe Gln Asn Lys  Glu Gln Asp 
    1970                 1975                 1980             


Leu Glu  Val Ile Leu His Asn  Gly Ala Cys Ser Pro  Gly Ala Arg 
    1985                 1990                 1995             


Gln Thr  Cys Met Lys Ser Ile  Glu Val Lys His Asp  Gly Leu Ser 
    2000                 2005                 2010             


Val Glu  Leu His Ser Asp Met  Glu Val Thr Val Asn  Gly Arg Leu 
    2015                 2020                 2025             


Val Ser  Val Pro Tyr Ile Gly  Gly Asn Met Glu Val  Ser Val Tyr 
    2030                 2035                 2040             


Gly Ala  Ile Met His Glu Ile  Arg Phe Asn His Leu  Gly His Ile 
    2045                 2050                 2055             


Phe Thr  Phe Thr Pro Gln Asn  Asn Glu Phe Gln Leu  Gln Leu Ser 
    2060                 2065                 2070             


Pro Lys  Thr Phe Ala Ser Lys  Met Tyr Gly Leu Cys  Gly Ile Cys 
    2075                 2080                 2085             


Asp Glu  Asn Gly Ala Asn Asp  Phe Met Leu Arg Asp  Gly Thr Val 
    2090                 2095                 2100             


Thr Thr  Asp Gln Arg Thr Phe  Ile Gln Glu Trp Thr  Met Gln Gln 
    2105                 2110                 2115             


Pro Gly  Gln Thr Cys Gln Pro  Ile Pro Glu Glu Gln  Cys Pro Val 
    2120                 2125                 2130             


Ser Ser  Ser Ser His Cys Gln  Val Leu Leu Ser Ala  Leu Phe Ala 
    2135                 2140                 2145             


Glu Cys  His Lys Val Leu Ala  Pro Asp Thr Phe Tyr  Ala Ile Cys 
    2150                 2155                 2160             


Gln Gln  Asp Ser Cys His Arg  Glu Gln Val Cys Glu  Val Ile Ala 
    2165                 2170                 2175             


Ser Tyr  Ala His Leu Cys Arg  Thr Asn Gly Val Cys  Val Asp Trp 
    2180                 2185                 2190             


Arg Thr  Thr Asp Phe Cys Ala  Met Ser Cys Pro Pro  Ser Leu Val 
    2195                 2200                 2205             


Tyr Asn  His Cys Glu His Gly  Cys Pro Gln His Cys  Glu Gly Asn 
    2210                 2215                 2220             


Thr Ser  Ser Cys Gly Asp His  Pro Ser Glu Gly Cys  Phe Cys Pro 
    2225                 2230                 2235             


Pro His  Gln Val Leu Leu Glu  Gly Ser Cys Val Pro  Glu Glu Ala 
    2240                 2245                 2250             


Cys Thr  Gln Cys Ile Ser Glu  Asp Gly Val Arg His  Gln Phe Leu 
    2255                 2260                 2265             


Glu Thr  Trp Val Pro Asp His  Gln Pro Cys Gln Ile  Cys Met Cys 
    2270                 2275                 2280             


Leu Ser  Gly Arg Lys Val Asn  Cys Thr Ser Gln Pro  Cys Pro Thr 
    2285                 2290                 2295             


Ala Arg  Ala Pro Thr Cys Gly  Pro Cys Glu Val Ala  Arg Leu His 
    2300                 2305                 2310             


Gln Asn  Pro Asp Gln Cys Cys  Pro Glu Tyr Glu Cys  Val Cys Asp 
    2315                 2320                 2325             


Leu Val  Ser Cys Asp Leu Pro  Pro Val Pro His Cys  Glu Gly Gly 
    2330                 2335                 2340             


Leu Gln  Pro Thr Leu Thr Asn  Pro Gly Glu Cys Arg  Pro Asn Phe 
    2345                 2350                 2355             


Thr Cys  Ala Cys Arg Lys Glu  Glu Cys Arg Arg Glu  Ser Pro Pro 
    2360                 2365                 2370             


Ser Cys  Pro Pro His Arg Thr  Pro Thr Leu Arg Lys  Thr Gln Cys 
    2375                 2380                 2385             


Cys Asp  Glu Tyr Glu Cys Ala  Cys Asn Cys Val Asn  Ser Thr Val 
    2390                 2395                 2400             


Ser Cys  Pro Leu Gly Tyr Leu  Ala Ser Val Val Thr  Asn Asp Cys 
    2405                 2410                 2415             


Gly Cys  Thr Thr Thr Thr Cys  Leu Pro Asp Lys Val  Cys Val His 
    2420                 2425                 2430             


Arg Gly  Thr Ile Tyr Pro Val  Gly Gln Phe Trp Glu  Glu Gly Cys 
    2435                 2440                 2445             


Asp Val  Cys Thr Cys Thr Asp  Met Glu Asp Ala Val  Met Gly Leu 
    2450                 2455                 2460             


Arg Val  Ala Gln Cys Ser Gln  Lys Pro Cys Glu Asp  Gly Cys Arg 
    2465                 2470                 2475             


Ser Gly  Phe Thr Tyr Val Leu  His Glu Gly Glu Cys  Cys Gly Arg 
    2480                 2485                 2490             


Cys Leu  Pro Ser Ala Cys Glu  Val Val Thr Gly Ser  Pro Arg Gly 
    2495                 2500                 2505             


Asp Ser  Gln Ser Tyr Trp Lys  Ser Val Gly Ser His  Trp Ala Ser 
    2510                 2515                 2520             


Pro Glu  Asn Pro Cys Leu Leu  Asn Glu Cys Val Arg  Val Lys Glu 
    2525                 2530                 2535             


Glu Val  Phe Val Gln Gln Arg  Asn Val Ser Cys Pro  Gln Leu Asp 
    2540                 2545                 2550             


Val Pro  Thr Cys Pro Val Gly  Phe Gln Leu Ser Cys  Lys Thr Ser 
    2555                 2560                 2565             


Glu Cys  Cys Pro Thr Cys His  Cys Glu Pro Val Glu  Ala Cys Val 
    2570                 2575                 2580             


Leu Asn  Gly Thr Ile Ile Gly  Pro Gly Lys Ser Leu  Met Ile Asp 
    2585                 2590                 2595             


Val Cys  Thr Thr Cys His Cys  Thr Val Gln Val Gly  Val Ile Ser 
    2600                 2605                 2610             


Gly Phe  Lys Leu Glu Cys Arg  Lys Thr Thr Cys Glu  Ala Cys Pro 
    2615                 2620                 2625             


Leu Gly  Tyr Lys Glu Glu Lys  Ile Gln Gly Glu Cys  Cys Gly Arg 
    2630                 2635                 2640             


Cys Leu  Pro Met Ala Cys Thr  Ile Gln Leu Arg Gly  Gly Gln Ile 
    2645                 2650                 2655             


Met Thr  Leu Gln Arg Asp Glu  Thr Ile Gln Asp Gly  Cys Asp Ser 
    2660                 2665                 2670             


His Phe  Cys Lys Val Asn Glu  Arg Gly Glu Tyr Ile  Trp Glu Lys 
    2675                 2680                 2685             


Arg Val  Thr Gly Cys Pro Pro  Phe Asp Glu His Lys  Cys Leu Ala 
    2690                 2695                 2700             


Glu Gly  Gly Lys Ile Met Lys  Ile Pro Gly Thr Cys  Cys Asp Thr 
    2705                 2710                 2715             


Cys Glu  Glu Pro Glu Cys Lys  Asp Ile Thr Ala Arg  Leu Gln Tyr 
    2720                 2725                 2730             


Val Lys  Val Gly Asp Cys Lys  Ser Glu Glu Glu Val  Asp Ile His 
    2735                 2740                 2745             


Tyr Cys  Gln Gly Lys Cys Ala  Ser Lys Ala Val Tyr  Ser Ile Asp 
    2750                 2755                 2760             


Thr Glu  Asp Val Gln Asp Gln  Cys Ser Cys Cys Ser  Pro Thr Arg 
    2765                 2770                 2775             


Thr Glu  Pro Met Arg Val Pro  Leu His Cys Thr Asn  Gly Ser Val 
    2780                 2785                 2790             


Val Tyr  His Glu Val Leu Asn  Ala Met Gln Cys Lys  Cys Ser Pro 
    2795                 2800                 2805             


Arg Lys  Cys Ser Lys 
    2810             


<210>  64
<211>  4377
<212>  DNA
<213>  Primate/Rodent

<400>  64
atgcagattg agctgtccac ttgctttttc ctgtgcctgc tgcagttttc attttccgcc       60

actagaagat actacctggg ggctgtcgaa ctgtcctggg attacatgca gtccgacctg      120

ctgtctgagc tgcatgtgga cacccgattt ccacctcgcg tcccacgaag cttccccttt      180

aatacatccg tgatgtacaa gaaaactgtg ttcgtcgagt tcaccgatca cctgttcaac      240

atcgcaaagc cccggccacc ctggatggga ctgctgggcc ctaccatcag agccgaggtg      300

tacgacaccg tggtcattac actgaaaaac atggcaagtc accccgtgtc actgcatgcc      360

gtgggagtct cctactggaa ggcatctgaa ggcgccgagt atgacgatca gactagtcag      420

agagaaaaag aggacgataa ggtgtttccc ggagaatctc atacctatgt gtggcaggtc      480

ctgaaggaga atggccctat ggccagcgac cctccatgcc tgacctactc ctatctgtct      540

cacgtggacc tggtcaaaga tctgaactcc gggctgatcg gagccctgct ggtgtgtcgg      600

gaaggatctc tggctaagga gagaacccag acactgcatc agttcgtgct gctgttcgct      660

gtctttgacg aaggcaaaag ttggcactca gagacaaagg attccctgac tcaggcaatg      720

gactctgcca gtgctagggc atggccaaaa atgcacaccg tgaacggcta cgtcaataga      780

agcctgccag gactgatcgg atgccacagg aagtccgtgt attggcatgt catcggcatg      840

gggaccacac cagaagtcca ctctattttc ctggagggac atacatttct ggtgcggaat      900

cacagacagg ctagcctgga gatctccccc attaccttcc tgacagcaca gactctgctg      960

atggatctgg gccagttcct gctgttttgc cacatcagct cccaccagca tgatgggatg     1020

gaggcctacg tgaaagtcga cagctgtcca gaggaacccc agctgaggat gaagaacaat     1080

gaggaagagg aagactacga cgatgacctg tatgacagcg agatggatgt ggtccgattc     1140

gatgacgata actcaccccc ttttatccag attagaagcg tcgccaagaa acaccctaag     1200

acttgggtgc attacatcgc cgctgaggaa gaggactggg attatgctcc ttccgtgctg     1260

accccagacg atcgcagcta caaatcccag tatctgaaca atggccctca gaggattggg     1320

cgcaagtaca agaaagtgag gttcatggct tataccgatg aaaccttcaa gactcgcgaa     1380

gcaatccagt acgagtccgg aattctgggc ccactgctgt atggggaagt gggagacacc     1440

ctgctgatca ttttcaagaa ccaggcctct aggccctaca atatctatcc tcatggcatt     1500

acagatgtgt ctcccctgca cagtggacgc ctgcctaagg gcgtgaaaca cctgaaggac     1560

ctgcctatcc tgccagggga aatttttaag tacaaatgga ctgtgaccgt cgaggatgga     1620

ccaactaaga gcgaccccag gtgcctgacc cgctactatt ctagtttcat caatctggaa     1680

agagatctgg caagcggact gatcggacca ctgctgattt gttacaaaga gtccgtggat     1740

cagcgaggca accagatgat gtctgacaag cggaatgtga tcctgttctc agtctttgac     1800

gaaaaccgca gctggtatct gaccgagaac atgcagcgat tcctgccaaa tgcagcagga     1860

gtgcagccac aggatcctga gtttcaggct agtaacatca tgcattcaat taatggctac     1920

gtgttcgact cactgcagct gagcgtgtgt ctgcacgagg tcgcttactg gtatatcctg     1980

agcgtcggag cacagacaga tttcctgtcc gtgttctttt ctggctacac ttttaagcat     2040

aaaatggtgt atgaggacac actgactctg ttcccttttt ccggcgaaac cgtctttatg     2100

tctatggaga atccagggct gtgggtgctg ggatgccaca actccgattt ccggaataga     2160

ggaatgactg ccctgctgaa agtgtcaagc tgtgaccgga acaccggcga ctactatgaa     2220

gatacatacg aggacatccc aacttatctg ctgtctgaaa acaatgtgat tgagcccaga     2280

agcttcagcc agaatccacc cgtgctgaag cgacaccagc gggaaatcac cctgactacc     2340

ctgcagtcag agcaggaaga gattgattac gacgatacca tcagcattga aacaaaaagg     2400

gaggacttcg atatctatgg ggaagacgag aaccagggac ctcgctcctt ccagaagagg     2460

acacgccatt actttattgc tgcagtggag aggctgtggg attatgggat gtcccgctct     2520

ccccacgtcc tgcgaaatcg ggcccagagt ggatcagtgc ctcagttcaa gaaagtggtc     2580

ttccaggagt ttactgacgg gagctttacc cagcctctgt accggggaga actgaacgag     2640

cacctgggac tgctgggccc atatatcaga gcagaagtgg aggataacat tatggtcacc     2700

ttcaagaatc aggccagtcg gccctactca ttttattcct ctctgatcag ctacgaagag     2760

gaccagcgcc agggcgcaga accacgaaaa aacttcgtga agcccaatga gaccaaaaca     2820

tacttttgga aggtgcagca ccatatggct cctacaaaag acgaattcga ttgcaaggcc     2880

tgggcttatt ttagtgacgt ggatctggag aaggacatgc actcagggct gatcggacct     2940

ctgctgattt gtcatactaa caccctgaat ccagcacacg gacgacaggt gacagtccag     3000

gaattcgctc tgttctttac aatcttcgat gagactaaga gctggtactt cactgaaaac     3060

atggagagaa attgcagggc cccttgtaat atccagatgg aagacccaac attcaaggag     3120

aactacagat ttcatgctat taatggctat gtgatggata ctctgccagg gctggtcatg     3180

gcacaggacc agagaatcag gtggtacctg ctgtctatgg ggagtaacga gaatatccac     3240

agcattcatt tctccggaca cgtgtttact gtcaggaaga aagaagagta taaaatggcc     3300

gtgtacaacc tgtatccagg cgtgttcgaa accgtcgaga tgctgccaag caaggcagga     3360

atctggcgag tggaatgcct gattggcgag cacctgcatg ctgggatgag taccctgttt     3420

ctggtgtact caaaacagtg tcagacacct ctgggaatgg catctggcca tatccgggat     3480

ttccagatta ccgcaagtgg acagtacgga cagtgggctc caaagctggc aagactgcac     3540

tatagcggct ccatcaacgc ctggtctaca aaagagccct ttagttggat taaggtggac     3600

ctgctggccc ctatgatcat tcatggcatc aaaactcagg gggctaggca gaagttcagt     3660

tcactgtaca tcagccagtt tatcatcatg tactccctgg atgggaagaa atggcagacc     3720

taccgcggga atagcacagg aactctgatg gtgttctttg gaaacgtcga cagctccggc     3780

atcaagcaca acattttcaa tcctccaatc attgcccgct acatccgact gcaccccacc     3840

cattattcaa ttcgaagcac actgcggatg gaactgatgg gctgcgatct gaactcttgt     3900

agtatgcctc tggggatgga gtctaaggcc atcagtgacg ctcagattac cgcatctagt     3960

tacttcacca atatgtttgc cacatggtca ccaagccagg ctaggctgca cctgcaggga     4020

agaacaaacg cctggaggcc tcaggtgaac aatccaaagg agtggctgca ggtggatttc     4080

cagaaaacta tgaaggtcac cggaatcaca actcagggcg tgaaatcact gctgaccagc     4140

atgtatgtga aggagtttct gatttcaagc tcccaggacg gccaccattg gacactgttc     4200

ctgcagaacg ggaaggtgaa agtcttccag ggaaatcagg attcttttac accagtggtc     4260

aacagtctgg acccccctct gctgactcgg tacctgagaa tccaccccca gagctgggtc     4320

catcagattg cactgcgact ggaagtgctg ggatgcgagg cacagcagct gtattga        4377


<210>  65
<211>  4362
<212>  DNA
<213>  Rodent

<400>  65
atgcagattg ccctgttcac ttgcttcttc ctgtccctgt tcaacttttg ttcctccgct       60

acccgccgat actacctggg ggctgtggag ctgtcctgga attacatgca gtctgacctg      120

ctgagtgtgc tgcacactga tacccggttc ctgcctagaa tgccaaccag tttccccttt      180

aatacatcaa tcatgtacaa gaaaaccgtg tttgtcgaat atatggacca tctgttcaac      240

attgcaaagc cccggccccc ttggatggga ctgctgggcc ctaccatctg gacagaggtg      300

cacgatacag tggtcattac tctgaagaac atggcttcac accctgtgag cctgcatgca      360

gtgggcgtct cttactggaa agccagtgag ggggctgaat atgaggacca gacaagtcag      420

agagaaaagg aggacgataa agtgtttcct ggagaatcac atacttacgt gtggcaggtc      480

ctgaaggaga atggcccaat ggcctctgat ccaccctgcc tgacatactc atatctgagc      540

cacgtggacc tggtcaaaga tctgaacagt gggctgatcg gagctctgct ggtgtgtaaa      600

gaaggatccc tgtctaagga gcggacccag atgctgcatc agttcgtgct gctgttcgca      660

gtctttgacg aaggcaaatc ctggcactct gagaccaagg actcctttac acaggcaatg      720

gatagtgcct caacaagagc ttggcccaag atgcacactg tgaacggcta cgtcaatcga      780

tccctgcctg gactgatcgg atgccaccga aaatctgtgt attggcatgt catcggcatg      840

gggaccacac cagaagtcca cagcattttt ctggaggggc ataccttcct ggtgcggaac      900

cacagacagg catccctgga gatctctccc attactttcc tgaccgccca gacactgctg      960

atcgacctgg ggcagttcct gctgttttgc catattagct cccacaaaca tgacggaatg     1020

gaggcttacg tgaaggtcga ttcctgtccc gaggaacctc agtggcagaa gaaaaacaac     1080

gaggaaatgg aagattacga cgatgacctg gactctgaga tggatatgtt taccctggat     1140

gacgataatt ctcctttcat ccagattcgg agtgtggcca agaaataccc aaagacctgg     1200

atccactata tttccgccga ggaagaggac tgggattacg ctccaagtgt gctgacatca     1260

gacgatggca gttacaagtc acagtatctg tctaacggcc cccataggat cgggcgcaaa     1320

tacaagaaag tgcgctttat tgcttatact gacgaaacct tcaagacacg agaaactatc     1380

cagcacgaga gcggaattct gggcccactg ctgtacgggg aagtgggaga tactctgctg     1440

atcattttca aaaaccaggc aagcagaccc tacaatatct atcctcatgg aattaccgac     1500

gtcagcccac tgcactcccg gagactgcct agaggcatca agcacgtgaa agatctgcca     1560

atcaggcccg gggaaatttt caagtataaa tggacagtga ctgtcgagga cggcccaacc     1620

aagagcgatc ccaggtgcct gacacgctac tattctagtt ttatcaatcc tgaaagggac     1680

ctggcaagcg gactgatcgg accactgctg atttgttaca aggagtctgt ggaccagagg     1740

ggcaaccaga tgatgagtga taaacgcaat gtgatcctgt tctcagtctt tgatgagaac     1800

cagagctggt atattaccga gaacatgcag cgctttctgc ctaatgccgc tgacacacag     1860

cctcaggatc cagaattcca ggcctcaaac atcatgcata gcattaatgg ctacgtgttt     1920

gacagcctgc agctgaccgt gtgtctgcac gaggtcgcat actggtatat cctgtccgtg     1980

ggagcccaga ccgactttct gtctattttc tttagtggct acacattcaa gcataaaatg     2040

gtgtatgagg ataccctgac actgttccca ttttccgggg aaaccgtctt catgtctatg     2100

gagaatcccg gactgtgggt gctgggctgc cacaacagcg actttcgaaa gcggggaatg     2160

actgccctgc tgaaagtgtc aagctgtgac aagagcacct ccgattacta tgaagagatc     2220

tacgaagaca ttcccacaca gctggtgaat gataacaatg tcatcgagcc taggagcttc     2280

tttcagaacc ctccagtgct gaagcgacac cagcgggagc tgtcagccct gcagagcgaa     2340

caggaggcta ccgactacga cgatagcatc accattgaaa caaatgagga cttcgatatc     2400

tatggagaag atatcaagca gggcccccgg agctttcagc agaagactag acattacttc     2460

atcgcagccg tcgagcgcct gtgggactat ggcatgtcta ccagtcctca cgtgctgaga     2520

aacagggatc agagcgggaa tgccccacag tttaagaaag tggtcttcca ggagtttaca     2580

gacggatcat tcagccagcc actgtaccgg ggcgaactga acgagcacct gggactgctg     2640

ggcccctata tcagagctga agtggaggac aacattatgg tcacctttaa gaatcaggca     2700

tccaggcctt actctttcta ttcctctctg atctcctaca aagaagatca gcgccagggc     2760

gaagagccaa ggcgcaactt tgtcaagccc aatgagacta aaatctactt ctggaaggtg     2820

cagcaccata tggctccaac cgaagacgag tttgattgca aggcttgggc atatttctca     2880

gacgtggatc tggagcggga catgcacagc gggctgatcg gacccctgct gatttgtcat     2940

actaacaccc tgaatcctgc ccacggcaga caggtggctg tccaggaatt tgcactgttc     3000

tttactatct tcgacgagac caaaagctgg tacttcactg aaaacgtgga gaggaattgc     3060

aagacccctt gtaatatcca gatggaagat ccaaccctga aagagaacta ccgctttcac     3120

gccattaatg gctatgtgat ggacacactg cccggactgg tcatggctca ggatcagcgc     3180

atccgatggt acctgctgag catggggtcc aacgagaata tccagagtat tcacttttca     3240

ggacatgtgt tcacagtcag aaagaaagaa gagtataaga tggccgtgta caacctgtat     3300

ccaggcgtgt tcgaaactgt cgagatgctg ccctccagag cagggatctg gagggtggaa     3360

tgcctgattg gggagcatct gcaggccgga atgagtaccc tgttcctggt gtactcaaag     3420

cagtgtcaga tccctctggg aatggcctcc ggctctatcc gggactttca gattacagct     3480

tctggccact atgggcagtg ggcaccaaat ctggccagac tgcaccatag tgggtcaatc     3540

aacgcatgga gcaccaaaga gccattctcc tggattaagg tggatctgct gacacccatg     3600

atcattcatg ggatcaaaac tcagggagcc aggcagaagt ttagttcact gtacattagc     3660

cagttcatca ttatgtattc cctggacggc aagaaatggc tgtcctaccg cgggaattct     3720

acaggaactc tgatggtgtt ctttggcaac gtcgatagct ccgggatcaa gcacaactcc     3780

tttaatcccc ctatcattgc cagatatatc aggctgcacc ccactcattc tagtattcga     3840

tctaccctgc ggatggaact gatggggtgc gacctgaata gctgttccat ccctctggga     3900

atggagaaca aagtgatcag cgatactcag attaccgcct caagctactt cacaaacatg     3960

tttgcaactt ggtctcccag tcaggcaagg ctgcacctgc agggacgaac caacgcttgg     4020

cgacctcagg tcaatgaccc aaaggagtgg ctgcaggtgg atctgcagaa gaccatgaaa     4080

gtcacaggca tcattactca gggggtgaaa agcctgttca catccatgtt tgtgaaggag     4140

ttcctgatct cctctagtca ggacggccac cattggactc acattctgca taacggaaag     4200

gtgaaagtct tccagggcaa tcaggactca agcacaccca tggtgaacag cctggatcca     4260

cccctgctga ctcgctacct gcgaatccac cctcagattt gggagcatca gatcgctctg     4320

cgcctggaaa ttctgggctg cgaggcacag cagctgtatt ga                        4362


<210>  66
<211>  2359
<212>  PRT
<213>  Primate/Rodent

<400>  66

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Ser 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Ile Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Phe Gly Glu Arg Thr Gln Met Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Gly Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Gly Thr Thr Ile Ala Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro 
            900                 905                 910         


Ser Asp Asn Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro 
        915                 920                 925             


Pro Asn Met Pro Val His Phe Ser Ser Gln Leu Gly Thr Thr Val Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Asn Leu 
945                 950                 955                 960 


Ser Glu Arg Asn Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Asn Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Arg Val  His Gly Pro Ala Leu  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Val  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Ser Asn Asn Ser Thr  Thr Asn Arg Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Ile Glu  Asn Ser Thr Ser Val  Trp Gln Asp 
    1040                 1045                 1050             


Ile Ile  Leu Glu Ser Asp Thr  Glu Phe Gln Glu Val  Thr Ser Leu 
    1055                 1060                 1065             


Ile His  Asp Glu Met Leu Met  Asp Lys Asn Thr Thr  Ala Leu Arg 
    1070                 1075                 1080             


Leu Asn  His Val Ser Asn Lys  Thr Thr Ser Ser Lys  Asn Met Glu 
    1085                 1090                 1095             


Met Val  His Gln Lys Lys Glu  Gly Pro Val Pro Pro  Asp Ala Glu 
    1100                 1105                 1110             


Asn Pro  Asp Met Ser Phe Phe  Lys Met Leu Phe Leu  Pro Glu Ser 
    1115                 1120                 1125             


Ala Asn  Trp Ile Lys Arg Thr  His Gly Lys Asn Ser  Leu Asn Ser 
    1130                 1135                 1140             


Gly Gln  Gly Pro Ser Pro Lys  Gln Leu Ile Ser Leu  Gly Ser Glu 
    1145                 1150                 1155             


Lys Ser  Val Lys Asp Gln Asn  Phe Leu Ser Glu Lys  Asn Lys Val 
    1160                 1165                 1170             


Val Val  Gly Glu Asp Glu Phe  Thr Lys Asp Thr Gly  Leu Lys Glu 
    1175                 1180                 1185             


Met Ile  Phe Pro Asn Ser Arg  Ser Ile Phe Leu Thr  Asn Leu Ala 
    1190                 1195                 1200             


Asn Val  Gln Glu Asn Asp Thr  His Asn Gln Glu Lys  Lys Phe Gln 
    1205                 1210                 1215             


Glu Glu  Ile Glu Arg Lys Glu  Thr Leu Ile Gln Glu  Asn Val Val 
    1220                 1225                 1230             


Leu Pro  Gln Val Tyr Thr Val  Thr Gly Thr Lys Asn  Phe Leu Lys 
    1235                 1240                 1245             


Asn Leu  Phe Leu Leu Ser Thr  Arg Gln Asn Val Glu  Gly Leu Asp 
    1250                 1255                 1260             


Glu Gly  Thr Tyr Ala Pro Val  Leu Gln Asp Thr Arg  Ser Leu Asn 
    1265                 1270                 1275             


Asp Ser  Thr Asn Arg Ala Glu  Ile His Met Ala His  Phe Ser Lys 
    1280                 1285                 1290             


Arg Arg  Glu Glu Glu Asn Leu  Glu Gly Leu Gly Asn  Gln Thr Lys 
    1295                 1300                 1305             


Gln Met  Val Glu Lys Tyr Pro  Ser Thr Thr Arg Met  Ser Pro Asn 
    1310                 1315                 1320             


Pro Ser  Gln Gln Asn Val Ile  Thr Gln Arg Gly Lys  Arg Ala Leu 
    1325                 1330                 1335             


Lys Gln  Phe Arg Leu Pro Leu  Glu Glu Thr Glu Leu  Glu Lys Gly 
    1340                 1345                 1350             


Leu Ile  Val Asp Asp Thr Ser  Thr Gln Trp Ser Lys  Asn Met Lys 
    1355                 1360                 1365             


Tyr Leu  Thr Gln Ser Thr Leu  Thr Gln Ile Asp Tyr  Asn Glu Lys 
    1370                 1375                 1380             


Glu Lys  Lys Ala Ile Thr Gln  Ser Pro Leu Ser Asp  Cys Ser Met 
    1385                 1390                 1395             


Arg Asn  His Ser Ile Thr Gln  Thr Asn Ser Ser Ala  Leu Pro Ile 
    1400                 1405                 1410             


Ala Lys  Val Ser Ala Phe Pro  Ser Ile Arg Pro Thr  Asp Leu Thr 
    1415                 1420                 1425             


Lys Ile  Pro Ser Gln Asp Asn  Ser Ser His Leu Leu  Ala Ser Ala 
    1430                 1435                 1440             


Tyr Ser  Tyr Thr Phe Arg Glu  Lys Ser Ser Gly Val  Gln Glu Ser 
    1445                 1450                 1455             


Ser His  Phe Leu Gln Gly Ala  Lys Arg Asn Asn Leu  Ser Leu Ala 
    1460                 1465                 1470             


Ile Leu  Thr Leu Glu Met Ile  Arg Asn Gln Glu Lys  Val Gly Ser 
    1475                 1480                 1485             


Leu Gly  Thr Ser Ala Thr Asn  Ser Val Met Tyr Lys  Lys Leu Glu 
    1490                 1495                 1500             


Asn Thr  Val Leu Leu Lys Pro  Gly Leu Pro Glu Ala  Ser Gly Lys 
    1505                 1510                 1515             


Val Glu  Leu Leu Pro Lys Val  His Ile His Gln Glu  Asp Leu Phe 
    1520                 1525                 1530             


Pro Thr  Glu Thr Ser Asn Gly  Ser Pro Gly His Leu  Asp Leu Met 
    1535                 1540                 1545             


Glu Glu  Ile Leu Leu Gln Lys  Thr Gln Gly Ala Ile  Lys Trp Asn 
    1550                 1555                 1560             


Lys Thr  Asn Arg Pro Gly Lys  Val Pro Phe Leu Lys  Gly Ala Thr 
    1565                 1570                 1575             


Glu Ser  Ser Glu Lys Thr Pro  Ser Lys Leu Leu Gly  Pro Leu Ala 
    1580                 1585                 1590             


Trp Asp  Asn Gln Tyr Ala Thr  Gln Ile Pro Lys Glu  Glu Trp Lys 
    1595                 1600                 1605             


Ser Gln  Glu Lys Ser Pro Lys  Asn Thr Ala Phe Lys  Thr Lys Asp 
    1610                 1615                 1620             


Thr Ile  Leu Ser Leu Asn Pro  Cys Glu Asn Asn His  Ala Ile Ala 
    1625                 1630                 1635             


Ala Ile  Asn Glu Gly Gln Asp  Arg Pro Gln Arg Glu  Ala Thr Trp 
    1640                 1645                 1650             


Ala Lys  Gln Gly Gly Thr Gly  Arg Leu Cys Ser Gln  Asn Pro Pro 
    1655                 1660                 1665             


Val Leu  Lys Arg His Gln Arg  Glu Ile Thr Leu Thr  Thr Leu Gln 
    1670                 1675                 1680             


Ser Glu  Gln Glu Glu Ile Asp  Tyr Asp Asp Thr Ile  Ser Ile Glu 
    1685                 1690                 1695             


Thr Lys  Arg Glu Asp Phe Asp  Ile Tyr Gly Glu Asp  Glu Asn Gln 
    1700                 1705                 1710             


Gly Pro  Arg Ser Phe Gln Lys  Arg Thr Arg His Tyr  Phe Ile Ala 
    1715                 1720                 1725             


Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met Ser Arg  Ser Pro His 
    1730                 1735                 1740             


Val Leu  Arg Asn Arg Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys 
    1745                 1750                 1755             


Lys Val  Val Phe Gln Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro 
    1760                 1765                 1770             


Leu Tyr  Arg Gly Glu Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro 
    1775                 1780                 1785             


Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile Met Val  Thr Phe Lys 
    1790                 1795                 1800             


Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser 
    1805                 1810                 1815             


Tyr Glu  Glu Asp Gln Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe 
    1820                 1825                 1830             


Val Lys  Pro Asn Glu Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His 
    1835                 1840                 1845             


His Met  Ala Pro Thr Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala 
    1850                 1855                 1860             


Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp Met His  Ser Gly Leu 
    1865                 1870                 1875             


Ile Gly  Pro Leu Leu Ile Cys  His Thr Asn Thr Leu  Asn Pro Ala 
    1880                 1885                 1890             


His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 
    1895                 1900                 1905             


Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu 
    1910                 1915                 1920             


Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr 
    1925                 1930                 1935             


Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Val Met 
    1940                 1945                 1950             


Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg 
    1955                 1960                 1965             


Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 
    1970                 1975                 1980             


His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr 
    1985                 1990                 1995             


Lys Met  Ala Val Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 
    2000                 2005                 2010             


Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu 
    2015                 2020                 2025             


Ile Gly  Glu His Leu His Ala  Gly Met Ser Thr Leu  Phe Leu Val 
    2030                 2035                 2040             


Tyr Ser  Lys Gln Cys Gln Thr  Pro Leu Gly Met Ala  Ser Gly His 
    2045                 2050                 2055             


Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 
    2060                 2065                 2070             


Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 
    2075                 2080                 2085             


Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu 
    2090                 2095                 2100             


Ala Pro  Met Ile Ile His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln 
    2105                 2110                 2115             


Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 
    2120                 2125                 2130             


Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly 
    2135                 2140                 2145             


Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys 
    2150                 2155                 2160             


His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 
    2165                 2170                 2175             


His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 
    2180                 2185                 2190             


Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu 
    2195                 2200                 2205             


Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe 
    2210                 2215                 2220             


Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His 
    2225                 2230                 2235             


Leu Gln  Gly Arg Thr Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 
    2240                 2245                 2250             


Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Lys Val Thr 
    2255                 2260                 2265             


Gly Ile  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 
    2270                 2275                 2280             


Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Asp Gly  His His Trp 
    2285                 2290                 2295             


Thr Leu  Phe Leu Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 
    2300                 2305                 2310             


Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu 
    2315                 2320                 2325             


Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln Ser Trp  Val His Gln 
    2330                 2335                 2340             


Ile Ala  Leu Arg Leu Glu Val  Leu Gly Cys Glu Ala  Gln Gln Leu 
    2345                 2350                 2355             


Tyr 
    


<210>  67
<211>  2359
<212>  PRT
<213>  Primate/Rodent

<400>  67

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Gln Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Asp Asp Ser Glu Met Asp Val Leu Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Ser 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Ile Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Phe Gly Glu Arg Thr Gln Met Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Gly Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Asp Ile Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Gly Thr Thr Ile Ala Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro 
            900                 905                 910         


Ser Asp Asn Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro 
        915                 920                 925             


Pro Asn Met Pro Val His Phe Ser Ser Gln Leu Gly Thr Thr Val Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Ser Leu 
945                 950                 955                 960 


Ser Glu Arg Asn Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Asn Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Arg Val  His Gly Pro Ala Leu  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Val  Lys Thr Asn 
    1010                 1015                 1020             


Lys Ala  Ser Asn Asn Ser Thr  Thr Asn Gly Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Ile Glu  Asn Ser Thr Ser Val  Trp Gln Asp 
    1040                 1045                 1050             


Ile Ile  Leu Glu Ser Asp Thr  Glu Phe Gln Glu Val  Thr Ser Leu 
    1055                 1060                 1065             


Ile His  Asp Glu Met Phe Met  Asp Lys Asn Thr Thr  Ala Leu Arg 
    1070                 1075                 1080             


Leu Asn  His Val Ser Asn Lys  Thr Thr Ser Ser Lys  Asn Met Glu 
    1085                 1090                 1095             


Met Val  His Gln Lys Lys Glu  Gly Pro Val Pro Pro  Asp Ala Glu 
    1100                 1105                 1110             


Asn Pro  Asp Met Ser Phe Phe  Lys Met Leu Phe Leu  Pro Glu Ser 
    1115                 1120                 1125             


Ala Asn  Trp Ile Lys Arg Thr  His Gly Lys Asn Ser  Leu Asn Ser 
    1130                 1135                 1140             


Gly Gln  Gly Pro Ser Pro Lys  Gln Leu Ile Ser Leu  Gly Ser Glu 
    1145                 1150                 1155             


Lys Ser  Val Lys Asp Gln Asn  Phe Leu Ser Glu Lys  Asn Lys Val 
    1160                 1165                 1170             


Val Val  Gly Glu Asp Glu Phe  Thr Lys Asp Thr Gly  Leu Lys Glu 
    1175                 1180                 1185             


Met Ile  Phe Pro Ser Ser Arg  Ser Ile Phe Leu Thr  Asn Leu Ala 
    1190                 1195                 1200             


Asn Val  Gln Glu Asn Asp Thr  His Asn Gln Glu Lys  Lys Phe Gln 
    1205                 1210                 1215             


Glu Glu  Ile Glu Arg Lys Glu  Thr Leu Ile Gln Glu  Asn Val Val 
    1220                 1225                 1230             


Leu Pro  Gln Val Tyr Thr Val  Thr Gly Thr Lys Asn  Phe Leu Lys 
    1235                 1240                 1245             


Asn Leu  Phe Leu Leu Ser Thr  Arg Gln Asn Val Glu  Gly Leu Asp 
    1250                 1255                 1260             


Glu Gly  Thr Tyr Ala Pro Val  Leu Gln Asp Thr Arg  Ser Leu Asn 
    1265                 1270                 1275             


Asp Ser  Ala Asn Arg Ala Glu  Ile His Met Ala His  Phe Ser Lys 
    1280                 1285                 1290             


Arg Arg  Glu Glu Glu Asn Leu  Glu Gly Leu Arg Asn  Gln Thr Lys 
    1295                 1300                 1305             


Gln Met  Val Glu Lys Tyr Pro  Ser Thr Thr Arg Met  Ser Pro Asn 
    1310                 1315                 1320             


Pro Ser  Gln Gln Asn Val Ile  Thr Gln Arg Gly Lys  Arg Ala Leu 
    1325                 1330                 1335             


Lys Gln  Phe Arg Leu Pro Leu  Glu Glu Ile Glu Leu  Glu Arg Gly 
    1340                 1345                 1350             


Leu Ile  Val Asp Asp Thr Ser  Thr Gln Trp Ser Lys  Asn Met Lys 
    1355                 1360                 1365             


Tyr Leu  Thr Gln Gly Thr Leu  Thr Gln Ile Asp Tyr  Asn Glu Lys 
    1370                 1375                 1380             


Glu Lys  Lys Ala Ile Thr Gln  Ser Pro Leu Ser Asp  Cys Pro Met 
    1385                 1390                 1395             


Arg Asn  His Gly Ile Thr Gln  Met Asn Ser Ser Ala  Leu Pro Ile 
    1400                 1405                 1410             


Ala Lys  Val Ser Ala Phe Pro  Ser Ile Arg Pro Thr  Asp Leu Thr 
    1415                 1420                 1425             


Lys Ile  Pro Ser Gln Asp Asn  Ser Ser His Leu Leu  Ala Ser Ala 
    1430                 1435                 1440             


Cys Asn  Tyr Thr Phe Arg Glu  Arg Ser Ser Gly Val  Gln Glu Ser 
    1445                 1450                 1455             


Ser His  Phe Leu Gln Gly Ala  Lys Arg Asn Asn Leu  Ser Leu Ala 
    1460                 1465                 1470             


Ile Leu  Thr Leu Glu Met Ile  Arg Asn Gln Gly Lys  Val Gly Ser 
    1475                 1480                 1485             


Leu Gly  Thr Ser Ala Thr Asn  Ser Val Met Tyr Lys  Lys Leu Glu 
    1490                 1495                 1500             


Asn Thr  Val Leu Leu Lys Pro  Gly Leu Pro Glu Ala  Ser Gly Lys 
    1505                 1510                 1515             


Val Glu  Leu Leu Pro Lys Val  His Ile His Gln Glu  Asp Leu Phe 
    1520                 1525                 1530             


Pro Thr  Glu Thr Ser Asn Gly  Ser Pro Gly His Leu  Asp Leu Met 
    1535                 1540                 1545             


Glu Glu  Ile Leu Leu Gln Lys  Thr Gln Gly Ala Ile  Lys Trp Asn 
    1550                 1555                 1560             


Lys Ala  Asn Arg Pro Gly Lys  Val Pro Phe Leu Lys  Gly Ala Thr 
    1565                 1570                 1575             


Glu Ser  Ser Glu Lys Thr Pro  Ser Lys Leu Leu Gly  Pro Leu Ala 
    1580                 1585                 1590             


Trp Asp  Asn Gln Tyr Ala Thr  Gln Ile Pro Lys Glu  Glu Trp Lys 
    1595                 1600                 1605             


Ser Gln  Glu Lys Ser Pro Lys  Asn Thr Ala Phe Lys  Thr Lys Asp 
    1610                 1615                 1620             


Thr Ile  Leu Ser Leu Asn Pro  Cys Glu Ser Asn His  Ala Ile Ala 
    1625                 1630                 1635             


Ala Ile  Asn Glu Gly Gln Asp  Arg Pro Gln Arg Glu  Ala Thr Trp 
    1640                 1645                 1650             


Ala Lys  Gln Gly Gly Thr Gly  Arg Leu Cys Ser Gln  Asn Pro Pro 
    1655                 1660                 1665             


Val Leu  Lys Arg His Gln Arg  Glu Ile Thr Leu Thr  Thr Leu Gln 
    1670                 1675                 1680             


Ser Glu  Gln Glu Glu Ile Asp  Tyr Asp Asp Thr Ile  Ser Ile Glu 
    1685                 1690                 1695             


Met Lys  Arg Glu Asp Phe Asp  Ile Tyr Gly Glu Asp  Glu Asn Gln 
    1700                 1705                 1710             


Gly Pro  Arg Ser Phe Gln Lys  Arg Thr Arg His Tyr  Phe Ile Ala 
    1715                 1720                 1725             


Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met Ser Ser  Ser Pro His 
    1730                 1735                 1740             


Val Leu  Arg Asn Arg Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys 
    1745                 1750                 1755             


Lys Val  Val Phe Gln Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro 
    1760                 1765                 1770             


Leu Tyr  Arg Gly Glu Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro 
    1775                 1780                 1785             


Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile Met Val  Thr Phe Lys 
    1790                 1795                 1800             


Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser 
    1805                 1810                 1815             


Tyr Glu  Glu Asp Gln Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe 
    1820                 1825                 1830             


Val Lys  Pro Asn Glu Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His 
    1835                 1840                 1845             


His Met  Ala Pro Thr Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala 
    1850                 1855                 1860             


Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp Met His  Ser Gly Leu 
    1865                 1870                 1875             


Ile Gly  Pro Leu Leu Ile Cys  His Thr Asn Thr Leu  Asn Pro Ala 
    1880                 1885                 1890             


His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 
    1895                 1900                 1905             


Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu 
    1910                 1915                 1920             


Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr 
    1925                 1930                 1935             


Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Val Met 
    1940                 1945                 1950             


Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg 
    1955                 1960                 1965             


Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 
    1970                 1975                 1980             


His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr 
    1985                 1990                 1995             


Lys Met  Ala Val Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 
    2000                 2005                 2010             


Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu 
    2015                 2020                 2025             


Ile Gly  Glu His Leu His Ala  Gly Met Ser Thr Leu  Phe Leu Val 
    2030                 2035                 2040             


Tyr Ser  Lys Gln Cys Gln Thr  Pro Leu Gly Met Ala  Ser Gly His 
    2045                 2050                 2055             


Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 
    2060                 2065                 2070             


Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 
    2075                 2080                 2085             


Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu 
    2090                 2095                 2100             


Ala Pro  Met Ile Ile His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln 
    2105                 2110                 2115             


Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 
    2120                 2125                 2130             


Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly 
    2135                 2140                 2145             


Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys 
    2150                 2155                 2160             


His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 
    2165                 2170                 2175             


His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 
    2180                 2185                 2190             


Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu 
    2195                 2200                 2205             


Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe 
    2210                 2215                 2220             


Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His 
    2225                 2230                 2235             


Leu Gln  Gly Arg Thr Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 
    2240                 2245                 2250             


Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Lys Val Thr 
    2255                 2260                 2265             


Gly Ile  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 
    2270                 2275                 2280             


Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Asp Gly  His His Trp 
    2285                 2290                 2295             


Thr Leu  Phe Leu Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 
    2300                 2305                 2310             


Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu 
    2315                 2320                 2325             


Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln Ser Trp  Val His Gln 
    2330                 2335                 2340             


Ile Ala  Leu Arg Leu Glu Val  Leu Gly Cys Glu Ala  Gln Gln Leu 
    2345                 2350                 2355             


Tyr 
    


<210>  68
<211>  2324
<212>  PRT
<213>  Rodent

<400>  68

Met Gln Ile Ala Leu Phe Thr Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Met Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Thr 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Pro Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Met Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Phe Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Thr Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Trp Gln Lys Lys Asn Asn Glu Glu Met Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Asp Ser Glu Met Asp Met Phe Thr Leu Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys Thr Trp 
385                 390                 395                 400 


Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Ser 
                405                 410                 415     


Val Leu Thr Ser Asp Asp Gly Ser Tyr Lys Ser Gln Tyr Leu Ser Asn 
            420                 425                 430         


Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Ile Ala 
        435                 440                 445             


Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln His Glu Ser 
    450                 455                 460                 


Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu 
465                 470                 475                 480 


Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His 
                485                 490                 495     


Gly Ile Thr Asp Val Ser Pro Leu His Ser Arg Arg Leu Pro Arg Gly 
            500                 505                 510         


Ile Lys His Val Lys Asp Leu Pro Ile Arg Pro Gly Glu Ile Phe Lys 
        515                 520                 525             


Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro 
    530                 535                 540                 


Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu Arg Asp 
545                 550                 555                 560 


Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser 
                565                 570                 575     


Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile 
            580                 585                 590         


Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr Glu Asn 
        595                 600                 605             


Met Gln Arg Phe Leu Pro Asn Ala Ala Asp Thr Gln Pro Gln Asp Pro 
    610                 615                 620                 


Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe 
625                 630                 635                 640 


Asp Ser Leu Gln Leu Thr Val Cys Leu His Glu Val Ala Tyr Trp Tyr 
                645                 650                 655     


Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Ile Phe Phe Ser 
            660                 665                 670         


Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu 
        675                 680                 685             


Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly 
    690                 695                 700                 


Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Lys Arg Gly Met 
705                 710                 715                 720 


Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Ser Thr Ser Asp Tyr 
                725                 730                 735     


Tyr Glu Glu Ile Tyr Glu Asp Ile Pro Thr Gln Leu Val Asn Asp Asn 
            740                 745                 750         


Asn Val Ile Glu Pro Arg Ser Phe Phe Gln Asn Ser Asn His Pro Asn 
        755                 760                 765             


Thr Arg Lys Lys Lys Phe Lys Ala Thr Thr Ile Pro Glu Asn Asp Ile 
    770                 775                 780                 


Glu Lys Ile Glu Pro Gln Phe Gly Glu Thr Ala Glu Met Leu Lys Val 
785                 790                 795                 800 


Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln Ser Pro 
                805                 810                 815     


Thr Pro His Gly Leu Ser Leu Ser Asp Asn Gln Glu Ala Ile Tyr Glu 
            820                 825                 830         


Ala Ile Pro Asp Asp His Ser Pro Asp Ala Ile Asp Ser Asn Glu Gly 
        835                 840                 845             


Pro Ser Lys Val Thr Gln Leu Arg Pro Glu Leu His His Ser Gly Lys 
    850                 855                 860                 


Ile Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Ser Asn Lys Asn 
865                 870                 875                 880 


Leu Glu Thr Thr Ile Glu Val Lys Trp Lys Lys Leu Asp Leu Gln Val 
                885                 890                 895     


Ser Ser Leu Pro Asn Asn Leu Met Thr Thr Thr Ile Leu Ser Asp Asn 
            900                 905                 910         


Leu Thr Ala Thr Ser Glu Lys Thr Asp Ser Ser Gly Ser Pro Asp Met 
        915                 920                 925             


Pro Val His Phe Ser Ser Lys Leu Ser Thr Thr Ala Phe Gly Lys Lys 
    930                 935                 940                 


Ser Tyr Pro Leu Ile Gly Ser His Val Pro Leu Asn Ile Ser Glu Arg 
945                 950                 955                 960 


Asn Ser Asp Ser Asn Leu Leu Asp Ala Thr Leu Met Asn Asn Gln Glu 
                965                 970                 975     


Ser Ser Leu Gly Asp Asn Ile Ser Ser Met Glu Asn Asp Arg Leu Leu 
            980                 985                 990         


Lys Glu Lys Arg Phe His Gly Ile  Ala Leu Leu Thr Lys  Asp Asn Thr 
        995                 1000                 1005             


Leu Phe  Lys Asp Asn Ile Ser  Leu Met Lys Thr Asn  Lys Thr Tyr 
    1010                 1015                 1020             


Asn His  Ser Thr Thr Asn Gly  Lys Ala His Ile Asp  Ser Pro Thr 
    1025                 1030                 1035             


Ser Ile  Glu Asn Ser Thr Ala  Val Leu Gln Asp Thr  Ile Leu Lys 
    1040                 1045                 1050             


Ile Asn  Ser Glu Ile Gln Glu  Val Thr Ser Leu Ile  His Asp Gly 
    1055                 1060                 1065             


Thr Leu  Ser Gly Lys Asn Thr  Thr Tyr Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Leu Asn  Arg Thr Thr Ser Ser  Lys Asn Lys Glu Ile  Phe His Gln 
    1085                 1090                 1095             


Lys Asp  Glu Asp Pro Val Pro  Gln Asp Thr Glu Asn  Thr Ile Met 
    1100                 1105                 1110             


Pro Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Asn Trp Met 
    1115                 1120                 1125             


Lys Arg  Thr Asn Gly Asn Asn  Ser Leu Asn Ser Glu  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Tyr  Leu Met Leu Glu Lys  Ser Val Lys 
    1145                 1150                 1155             


Asn Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Ile  Val Glu Gln 
    1160                 1165                 1170             


Asp Glu  Phe Thr Lys Asp Thr  Gly Leu Lys Asp Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Asn  Met Ser Ile Phe Leu  Thr Thr Leu Ala Asn  Val Gln Glu 
    1190                 1195                 1200             


Asn Asp  Met His Asn Gln Glu  Lys Asn Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Glu Glu  Lys Val Val Leu Pro  Gln Val His 
    1220                 1225                 1230             


Ile Ala  Thr Gly Ser Lys Asn  Phe Leu Lys Asp Ile  Phe Phe Leu 
    1235                 1240                 1245             


Gly Thr  Arg Gln Asn Val Ser  Leu Asp Glu Asp Ile  Tyr Val Pro 
    1250                 1255                 1260             


Val Leu  Gln Asp Ile Ser Ser  Ile Asn Asn Ser Thr  Asn Thr Val 
    1265                 1270                 1275             


Glu Ile  His Met Ala His Phe  Phe Lys Arg Arg Glu  Asp Glu Glu 
    1280                 1285                 1290             


Thr Asn  Ser Glu Gly Leu Val  Asn Lys Thr Arg Glu  Met Val Lys 
    1295                 1300                 1305             


Asn Tyr  Pro Ser Gln Lys Asn  Ile Ile Thr Gln Arg  Ser Lys Arg 
    1310                 1315                 1320             


Ala Leu  Gly Gln Phe Arg Leu  Pro Leu Ala Ser Thr  Gln Trp Pro 
    1325                 1330                 1335             


Gln Thr  Met Asn Tyr Leu Thr  Gln Ser Ile Ile Thr  Gln Ile Asp 
    1340                 1345                 1350             


His Ser  Lys Glu Gly Glu Lys  Ser Ile Thr Gln Ser  Ser Leu Ser 
    1355                 1360                 1365             


Asp Ser  Ser Met Ile Lys Ser  Thr Thr Gln Thr Asn  Ser Ser Gly 
    1370                 1375                 1380             


Leu His  Ile Val Lys Thr Ser  Ala Phe Pro Pro Thr  Asp Leu Lys 
    1385                 1390                 1395             


Arg Ile  Pro Phe Gln Asp Lys  Phe Phe His Val Leu  Ala Ser Ser 
    1400                 1405                 1410             


Tyr Thr  Tyr Asp Phe Lys Thr  Lys Ser Ser Arg Ile  Gln Glu Ser 
    1415                 1420                 1425             


Ser His  Phe Leu Lys Glu Thr  Lys Ile Asn Asn Ser  Ser Leu Ala 
    1430                 1435                 1440             


Ile Leu  Pro Trp Glu Met Ile  Ile Asn Gln Gly Lys  Phe Ala Ser 
    1445                 1450                 1455             


Pro Gly  Thr Ser Asn Thr Asn  Ser Val Thr Tyr Lys  Lys Leu Glu 
    1460                 1465                 1470             


Asn Ile  Val Leu Leu Lys Pro  Val Leu Pro Glu Glu  Ser Gly Lys 
    1475                 1480                 1485             


Val Glu  Leu Leu Pro Gln Val  Ser Ile His Glu Glu  Glu Leu Leu 
    1490                 1495                 1500             


Pro Thr  Glu Thr Ser His Gly  Ser Pro Gly His Leu  Asp Leu Met 
    1505                 1510                 1515             


Lys Glu  Val Phe Leu Gln Lys  Thr Gln Gly Pro Ile  Lys Trp Asn 
    1520                 1525                 1530             


Lys Ala  Lys Arg His Gly Glu  Ser Glu Leu Lys Gly  Thr Thr Glu 
    1535                 1540                 1545             


Ser Ser  Glu Lys Thr Pro Ser  Lys Leu Leu Asp His  Leu Ala Trp 
    1550                 1555                 1560             


Asp Asn  His Tyr Ala Ala Gln  Ile Pro Lys Asp Lys  Trp Lys Ser 
    1565                 1570                 1575             


Lys Glu  Lys Ser Pro Glu Ile  Thr Ser Ile Lys Arg  Glu Asp Thr 
    1580                 1585                 1590             


Ile Leu  Ser Leu Asn Pro His  Glu Asn Asn His Ser  Ile Val Ala 
    1595                 1600                 1605             


Asn Glu  Lys Gln Asn Trp Pro  Gln Arg Glu Ala Thr  Trp Val Lys 
    1610                 1615                 1620             


Gln Gly  Gln Thr Gln Arg Leu  Cys Ser Gln Asn Pro  Pro Val Leu 
    1625                 1630                 1635             


Lys Arg  His Gln Arg Glu Leu  Ser Ala Leu Gln Ser  Glu Gln Glu 
    1640                 1645                 1650             


Ala Thr  Asp Tyr Asp Asp Ser  Ile Thr Ile Glu Thr  Asn Glu Asp 
    1655                 1660                 1665             


Phe Asp  Ile Tyr Gly Glu Asp  Ile Lys Gln Gly Pro  Arg Ser Phe 
    1670                 1675                 1680             


Gln Gln  Lys Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu 
    1685                 1690                 1695             


Trp Asp  Tyr Gly Met Ser Thr  Ser Pro His Val Leu  Arg Asn Arg 
    1700                 1705                 1710             


Asp Gln  Ser Gly Asn Ala Pro  Gln Phe Lys Lys Val  Val Phe Gln 
    1715                 1720                 1725             


Glu Phe  Thr Asp Gly Ser Phe  Ser Gln Pro Leu Tyr  Arg Gly Glu 
    1730                 1735                 1740             


Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 
    1745                 1750                 1755             


Val Glu  Asp Asn Ile Met Val  Thr Phe Lys Asn Gln  Ala Ser Arg 
    1760                 1765                 1770             


Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Lys  Glu Asp Gln 
    1775                 1780                 1785             


Arg Gln  Gly Glu Glu Pro Arg  Arg Asn Phe Val Lys  Pro Asn Glu 
    1790                 1795                 1800             


Thr Lys  Ile Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1805                 1810                 1815             


Glu Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1820                 1825                 1830             


Asp Leu  Glu Arg Asp Met His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1835                 1840                 1845             


Ile Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1850                 1855                 1860             


Ala Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 
    1865                 1870                 1875             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Val Glu Arg Asn  Cys Lys Thr 
    1880                 1885                 1890             


Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Leu Lys  Glu Asn Tyr 
    1895                 1900                 1905             


Arg Phe  His Ala Ile Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly 
    1910                 1915                 1920             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1925                 1930                 1935             


Met Gly  Ser Asn Glu Asn Ile  Gln Ser Ile His Phe  Ser Gly His 
    1940                 1945                 1950             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr 
    1955                 1960                 1965             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 
    1970                 1975                 1980             


Arg Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    1985                 1990                 1995             


Gln Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Lys Gln Cys 
    2000                 2005                 2010             


Gln Ile  Pro Leu Gly Met Ala  Ser Gly Ser Ile Arg  Asp Phe Gln 
    2015                 2020                 2025             


Ile Thr  Ala Ser Gly His Tyr  Gly Gln Trp Ala Pro  Asn Leu Ala 
    2030                 2035                 2040             


Arg Leu  His His Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    2045                 2050                 2055             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Thr Pro  Met Ile Ile 
    2060                 2065                 2070             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    2075                 2080                 2085             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    2090                 2095                 2100             


Trp Leu  Ser Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    2105                 2110                 2115             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ser Phe Asn 
    2120                 2125                 2130             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Ser 
    2135                 2140                 2145             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    2150                 2155                 2160             


Asn Ser  Cys Ser Ile Pro Leu  Gly Met Glu Asn Lys  Val Ile Ser 
    2165                 2170                 2175             


Asp Thr  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    2180                 2185                 2190             


Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His Leu Gln  Gly Arg Thr 
    2195                 2200                 2205             


Asn Ala  Trp Arg Pro Gln Val  Asn Asp Pro Lys Glu  Trp Leu Gln 
    2210                 2215                 2220             


Val Asp  Leu Gln Lys Thr Met  Lys Val Thr Gly Ile  Ile Thr Gln 
    2225                 2230                 2235             


Gly Val  Lys Ser Leu Phe Thr  Ser Met Phe Val Lys  Glu Phe Leu 
    2240                 2245                 2250             


Ile Ser  Ser Ser Gln Asp Gly  His His Trp Thr His  Ile Leu His 
    2255                 2260                 2265             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Ser Thr 
    2270                 2275                 2280             


Pro Met  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    2285                 2290                 2295             


Arg Ile  His Pro Gln Ile Trp  Glu His Gln Ile Ala  Leu Arg Leu 
    2300                 2305                 2310             


Glu Ile  Leu Gly Cys Glu Ala  Gln Gln Leu Tyr 
    2315                 2320                 


<210>  69
<211>  2356
<212>  PRT
<213>  Rodent

<400>  69

Met Gln Ile Ala Leu Phe Thr Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Met Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Thr 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Pro Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Met Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Phe Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Thr Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Trp Gln Lys Lys Asn Asn Glu Glu Met Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Leu Asp Ser Glu Met Asp Met Phe Thr Leu Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys 
385                 390                 395                 400 


Thr Trp Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Ser Asp Asp Gly Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Ser Asn Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Ile Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln His 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Arg Arg Leu Pro 
            500                 505                 510         


Arg Gly Ile Lys His Val Lys Asp Leu Pro Ile Arg Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Asp Thr Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Thr Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Ile Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Lys Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Ser Thr Ser 
                725                 730                 735     


Asp Tyr Tyr Glu Glu Ile Tyr Glu Asp Ile Pro Thr Gln Leu Val Asn 
            740                 745                 750         


Asp Asn Asn Val Ile Glu Pro Arg Ser Phe Phe Gln Asn Ser Asn His 
        755                 760                 765             


Pro Asn Thr Arg Lys Lys Lys Phe Lys Ala Thr Thr Ile Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Glu Pro Gln Phe Gly Glu Thr Ala Glu Met Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Asn Gln Glu Ala Ile 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Asp Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Lys Val Thr Gln Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Lys Ile Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Ser Asn 
865                 870                 875                 880 


Lys Asn Leu Glu Thr Thr Ile Glu Val Lys Trp Lys Lys Leu Asp Leu 
                885                 890                 895     


Gln Val Ser Ser Leu Pro Asn Asn Leu Met Thr Thr Pro Thr Ile Leu 
            900                 905                 910         


Ser Asp Asn Leu Thr Ala Thr Ser Glu Lys Thr Asp Ser Ser Gly Ser 
        915                 920                 925             


Pro Asp Met Pro Val His Phe Ser Ser Lys Leu Ser Thr Thr Ala Phe 
    930                 935                 940                 


Gly Lys Lys Ser Tyr Pro Leu Ile Gly Ser His Val Pro Leu Ser Ile 
945                 950                 955                 960 


Ser Glu Arg Asn Ser Asp Ser Asn Leu Leu Asp Ala Thr Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Asp Asn Ile Ser Ser Met Glu Asn Asp 
            980                 985                 990         


Arg Leu Leu Lys Glu Lys Arg Phe  His Gly Ile Ala Leu  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Thr Leu Phe Lys Asp  Asn Ile Ser Leu Met  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Tyr Asn His Ser Thr  Thr Asn Gly Lys Ala  His Ile Asp 
    1025                 1030                 1035             


Ser Pro  Thr Ser Leu Ile Glu  Asn Ser Thr Ala Val  Leu Gln Asp 
    1040                 1045                 1050             


Thr Ile  Leu Lys Ile Asn Ser  Glu Ile Gln Glu Val  Thr Ser Leu 
    1055                 1060                 1065             


Ile His  Asp Gly Thr Leu Ser  Gly Lys Asn Thr Thr  Tyr Leu Arg 
    1070                 1075                 1080             


Leu Asn  His Met Leu Asn Arg  Thr Thr Ser Ser Lys  Asn Lys Glu 
    1085                 1090                 1095             


Ile Phe  His Gln Lys Asp Glu  Asp Pro Val Pro Gln  Asp Ala Glu 
    1100                 1105                 1110             


Asn Thr  Ile Met Pro Phe Phe  Lys Met Leu Phe Leu  Pro Glu Ser 
    1115                 1120                 1125             


Ala Asn  Trp Met Lys Arg Thr  Asn Gly Asn Asn Ser  Leu Asn Ser 
    1130                 1135                 1140             


Glu Gln  Gly Pro Ser Pro Lys  Gln Leu Val Tyr Leu  Met Leu Glu 
    1145                 1150                 1155             


Lys Ser  Val Lys Asn Gln Asn  Phe Leu Ser Glu Lys  Asn Lys Val 
    1160                 1165                 1170             


Ile Val  Glu Gln Asp Glu Phe  Thr Lys Asp Thr Gly  Leu Lys Asp 
    1175                 1180                 1185             


Met Val  Phe Pro Ser Asn Met  Ser Ile Phe Leu Thr  Thr Leu Ala 
    1190                 1195                 1200             


Asn Val  Gln Glu Asn Asp Met  His Asn Gln Glu Lys  Asn Ile Gln 
    1205                 1210                 1215             


Glu Glu  Ile Glu Lys Lys Glu  Ala Leu Ile Glu Glu  Lys Val Val 
    1220                 1225                 1230             


Leu Pro  Gln Val His Ile Ala  Thr Gly Ser Lys Asn  Phe Leu Lys 
    1235                 1240                 1245             


Asp Ile  Phe Phe Leu Gly Thr  Arg Gln Asn Val Val  Ser Leu Asp 
    1250                 1255                 1260             


Glu Glu  Ile Tyr Val Pro Val  Leu Gln Asp Ile Arg  Ser Ile Asn 
    1265                 1270                 1275             


Asn Ser  Thr Asn Thr Val Glu  Ile His Met Ala His  Phe Phe Lys 
    1280                 1285                 1290             


Arg Arg  Glu Asp Glu Asn Ser  Glu Gly Leu Val Asn  Lys Thr Arg 
    1295                 1300                 1305             


Glu Met  Val Lys Asn Tyr Pro  Ser Thr Thr Arg Met  Ser Pro Asn 
    1310                 1315                 1320             


Pro Ser  Gln Lys Asn Ile Ile  Thr Gln Arg Ser Lys  Arg Ala Leu 
    1325                 1330                 1335             


Gly Gln  Phe Arg Leu Pro Leu  Glu Glu Thr Glu Leu  Glu Lys Gln 
    1340                 1345                 1350             


Gln Ile  Val Asn Asn Ala Ser  Thr Gln Trp Pro Gln  Thr Met Asn 
    1355                 1360                 1365             


Tyr Leu  Thr Gln Ser Ile Ile  Thr Gln Ile Asp His  Ser Lys Glu 
    1370                 1375                 1380             


Gly Glu  Lys Ser Ile Thr Gln  Ser Ser Leu Ser Asp  Ser Ser Met 
    1385                 1390                 1395             


Ile Lys  Lys Ser Thr Thr Gln  Thr Asn Ser Ser Gly  Leu His Ile 
    1400                 1405                 1410             


Val Lys  Thr Ser Ala Phe Pro  Pro Ile Arg Pro Thr  Asp Leu Lys 
    1415                 1420                 1425             


Arg Ile  Pro Phe Gln Asp Lys  Phe Phe His Val Leu  Ala Ser Ser 
    1430                 1435                 1440             


Tyr Thr  Tyr Asp Phe Lys Thr  Lys Ser Ser Arg Ile  Gln Glu Ser 
    1445                 1450                 1455             


Ser His  Phe Leu Lys Glu Thr  Lys Ile Asn Asn Ser  Ser Leu Ala 
    1460                 1465                 1470             


Ile Leu  Pro Trp Glu Met Ile  Ile Asn Gln Gly Lys  Phe Ala Ser 
    1475                 1480                 1485             


Pro Gly  Thr Ser Asn Thr Asn  Ser Val Thr Tyr Lys  Lys Leu Glu 
    1490                 1495                 1500             


Asn Ile  Val Leu Leu Lys Pro  Val Leu Pro Glu Glu  Ser Gly Lys 
    1505                 1510                 1515             


Val Glu  Leu Leu Pro Gln Val  Ser Ile His Glu Glu  Glu Leu Leu 
    1520                 1525                 1530             


Pro Thr  Glu Thr Ser His Glu  Ser Pro Gly His Leu  Asp Leu Met 
    1535                 1540                 1545             


Lys Glu  Val Phe Leu Gln Lys  Thr Gln Gly Pro Ile  Lys Trp Asn 
    1550                 1555                 1560             


Lys Ala  Lys Arg His Gly Glu  Ser Pro Phe Leu Lys  Gly Thr Thr 
    1565                 1570                 1575             


Glu Ser  Ser Glu Lys Thr Pro  Ser Lys Leu Leu Asp  Pro Leu Ala 
    1580                 1585                 1590             


Trp Asp  Asn His Tyr Ala Ala  Gln Ile Pro Lys Asp  Lys Trp Lys 
    1595                 1600                 1605             


Ser Lys  Glu Lys Ser Pro Glu  Ile Thr Ser Ile Lys  Arg Glu Asp 
    1610                 1615                 1620             


Thr Ile  Leu Ser Leu Asn Pro  His Glu Asn Asn His  Ser Ile Val 
    1625                 1630                 1635             


Ala Ile  Asn Glu Lys Gln Asn  Trp Pro Gln Arg Glu  Ala Thr Trp 
    1640                 1645                 1650             


Val Lys  Gln Gly Gln Thr Gln  Arg Leu Cys Ser Gln  Asn Pro Pro 
    1655                 1660                 1665             


Val Leu  Lys Arg His Gln Arg  Glu Leu Ser Ala Leu  Gln Ser Glu 
    1670                 1675                 1680             


Gln Glu  Ala Thr Asp Tyr Asp  Asp Ala Ile Thr Ile  Glu Thr Asn 
    1685                 1690                 1695             


Glu Asp  Phe Asp Ile Tyr Gly  Glu Asp Ile Lys Gln  Gly Pro Arg 
    1700                 1705                 1710             


Ser Phe  Gln Gln Lys Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu 
    1715                 1720                 1725             


Arg Leu  Trp Asp Tyr Gly Met  Ser Thr Ser Pro His  Val Leu Arg 
    1730                 1735                 1740             


Asn Arg  Asp Gln Ser Gly Asn  Ala Pro Gln Phe Lys  Lys Val Val 
    1745                 1750                 1755             


Phe Gln  Glu Phe Thr Asp Gly  Ser Phe Ser Gln Pro  Leu Tyr Arg 
    1760                 1765                 1770             


Gly Glu  Leu Asn Glu His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg 
    1775                 1780                 1785             


Ala Glu  Val Glu Asp Asn Ile  Met Val Thr Phe Lys  Asn Gln Ala 
    1790                 1795                 1800             


Ser Arg  Pro Tyr Ser Phe Tyr  Ser Ser Leu Ile Ser  Tyr Lys Glu 
    1805                 1810                 1815             


Asp Gln  Arg Gln Gly Glu Glu  Pro Arg Arg Asn Phe  Val Lys Pro 
    1820                 1825                 1830             


Asn Glu  Thr Lys Ile Tyr Phe  Trp Lys Val Gln His  His Met Ala 
    1835                 1840                 1845             


Pro Thr  Glu Asp Glu Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser 
    1850                 1855                 1860             


Asp Val  Asp Leu Glu Arg Asp  Met His Ser Gly Leu  Ile Gly Pro 
    1865                 1870                 1875             


Leu Leu  Ile Cys His Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg 
    1880                 1885                 1890             


Gln Val  Ala Val Gln Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp 
    1895                 1900                 1905             


Glu Thr  Lys Ser Trp Tyr Phe  Thr Glu Asn Val Glu  Arg Asn Cys 
    1910                 1915                 1920             


Lys Thr  Pro Cys Asn Ile Gln  Met Glu Asp Pro Thr  Leu Lys Glu 
    1925                 1930                 1935             


Asn Tyr  Arg Phe His Ala Ile  Asn Gly Tyr Val Met  Asp Thr Leu 
    1940                 1945                 1950             


Pro Gly  Leu Val Met Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu 
    1955                 1960                 1965             


Leu Ser  Met Gly Ser Asn Glu  Asn Ile Gln Ser Ile  His Phe Ser 
    1970                 1975                 1980             


Gly His  Val Phe Thr Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala 
    1985                 1990                 1995             


Val Tyr  Asn Leu Tyr Pro Gly  Val Phe Glu Thr Val  Glu Met Leu 
    2000                 2005                 2010             


Pro Ser  Arg Ala Gly Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu 
    2015                 2020                 2025             


His Leu  Gln Ala Gly Met Ser  Thr Leu Phe Leu Val  Tyr Ser Lys 
    2030                 2035                 2040             


Gln Cys  Gln Ile Pro Leu Gly  Met Ala Ser Gly Ser  Ile Arg Asp 
    2045                 2050                 2055             


Phe Gln  Ile Thr Ala Ser Gly  His Tyr Gly Gln Trp  Ala Pro Asn 
    2060                 2065                 2070             


Leu Ala  Arg Leu His His Ser  Gly Ser Ile Asn Ala  Trp Ser Thr 
    2075                 2080                 2085             


Lys Glu  Pro Phe Ser Trp Ile  Lys Val Asp Leu Leu  Thr Pro Met 
    2090                 2095                 2100             


Ile Ile  His Gly Ile Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser 
    2105                 2110                 2115             


Ser Leu  Tyr Ile Ser Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly 
    2120                 2125                 2130             


Lys Lys  Trp Leu Ser Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met 
    2135                 2140                 2145             


Val Phe  Phe Gly Asn Val Asp  Ser Ser Gly Ile Lys  His Asn Ser 
    2150                 2155                 2160             


Phe Asn  Pro Pro Ile Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr 
    2165                 2170                 2175             


His Ser  Ser Ile Arg Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys 
    2180                 2185                 2190             


Asp Leu  Asn Ser Cys Ser Ile  Pro Leu Gly Met Glu  Asn Lys Val 
    2195                 2200                 2205             


Ile Ser  Asp Thr Gln Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met 
    2210                 2215                 2220             


Phe Ala  Thr Trp Ser Pro Ser  Gln Ala Arg Leu His  Leu Gln Gly 
    2225                 2230                 2235             


Arg Thr  Asn Ala Trp Arg Pro  Gln Val Asn Asp Pro  Lys Glu Trp 
    2240                 2245                 2250             


Leu Gln  Val Asp Leu Gln Lys  Thr Met Lys Val Thr  Gly Ile Ile 
    2255                 2260                 2265             


Thr Gln  Gly Val Lys Ser Leu  Phe Thr Ser Met Phe  Val Lys Glu 
    2270                 2275                 2280             


Phe Leu  Ile Ser Ser Ser Gln  Asp Gly His His Trp  Thr His Ile 
    2285                 2290                 2295             


Leu His  Asn Gly Lys Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser 
    2300                 2305                 2310             


Ser Thr  Pro Met Val Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg 
    2315                 2320                 2325             


Tyr Leu  Arg Ile His Pro Gln  Ile Trp Glu His Gln  Ile Ala Leu 
    2330                 2335                 2340             


Arg Leu  Glu Ile Leu Gly Cys  Glu Ala Gln Gln Leu  Tyr 
    2345                 2350                 2355     


