                         SEQUENCE LISTING

<110>  United Neuroscience
       UNS IP Holdings, LLC
       Wang, Chang-Yi
 
<120>  TAU PEPTIDE IMMUNOGEN CONSTRUCTS

<130>  1008578.102WO2 (UNS1002-TW)

<140>  PCT/US2018/057840
<141>  2018-10-26

<150>  US 62/578,124
<151>  2017-10-27

<160>  171   

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  pTau peptide - aa145-160 (pT149/pT153)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<400>  1

Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Tau peptide - aa145-160

<400>  2

Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
1               5                   10                  15      


<210>  3
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  pTau peptide - aa172-189 (pT175/pT181/pS185)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<400>  3

Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu 
1               5                   10                  15      


Pro Pro 
        


<210>  4
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  Tau peptide - aa172-189

<400>  4

Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu 
1               5                   10                  15      


Pro Pro 
        


<210>  5
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  pTau peptide - aa182-200 (pS184/pY197)

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  PHOSPHORYLATION

<400>  5

Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr 
1               5                   10                  15      


Ser Ser Pro 
            


<210>  6
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Tau peptide - aa182-200

<400>  6

Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr 
1               5                   10                  15      


Ser Ser Pro 
            


<210>  7
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  pTau peptide - aa195-213 (pS198/pS208/pS210)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  PHOSPHORYLATION

<400>  7

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr Pro 
            


<210>  8
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Tau peptide - aa195-213

<400>  8

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr Pro 
            


<210>  9
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  pTau peptide - aa 195-213 (pS199/pS202/pT205)

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  9

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr Pro 
            


<210>  10
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  pTau peptide - aa209-224 (pT212/pS214/pT217)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  PHOSPHORYLATION

<400>  10

Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
1               5                   10                  15      


<210>  11
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Tau peptide - aa209-224

<400>  11

Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  pTau peptide - aa228-243 (pT231/pS235/pS238)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  PHOSPHORYLATION

<400>  12

Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
1               5                   10                  15      


<210>  13
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Tau peptide - aa228-243

<400>  13

Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu 
1               5                   10                  15      


<210>  14
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  pTau peptide - aa257-274 (pS262)

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  PHOSPHORYLATION

<400>  14

Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210>  15
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  Tau peptide - aa257-274

<400>  15

Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
1               5                   10                  15      


Gly Lys 
        


<210>  16
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(30)
<223>  pTau peptide - aa379-408 (pS396/pS404)

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  PHOSPHORYLATION

<400>  16

Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
1               5                   10                  15      


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
            20                  25                  30  


<210>  17
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(30)
<223>  Tau peptide - aa379-408

<400>  17

Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
1               5                   10                  15      


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
            20                  25                  30  


<210>  18
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(37)
<223>  pTau peptide - aa275-311; *P301->S; (pS293/pS301)

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  PHOSPHORYLATION

<400>  18

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Ser Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys 
        35          


<210>  19
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(37)
<223>  Tau peptide - aa275-311

<400>  19

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys 
        35          


<210>  20
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(33)
<223>  pTau peptide - aa393-425 (pS396/pS404/pS422)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PHOSPHORYLATION

<400>  20

Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
1               5                   10                  15      


Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln 
            20                  25                  30          


Leu 
    


<210>  21
<211>  33
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(33)
<223>  Tau peptide - aa393-425

<400>  21

Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu 
1               5                   10                  15      


Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln 
            20                  25                  30          


Leu 
    


<210>  22
<211>  17
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Clostridium tetani 1 Th

<400>  22

Lys Lys Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Leu 
    


<210>  23
<211>  15
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  MvF1 Th

<400>  23

Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val 
1               5                   10                  15  


<210>  24
<211>  24
<212>  PRT
<213>  Bordetella pertussis


<220>
<221>  PEPTIDE
<222>  (1)..(24)
<223>  Bordetella pertussis Th

<400>  24

Gly Ala Tyr Ala Arg Cys Pro Asn Gly Thr Arg Ala Leu Thr Val Ala 
1               5                   10                  15      


Glu Leu Arg Gly Asn Ala Glu Leu 
            20                  


<210>  25
<211>  17
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Clostridium tetani 2 Th

<400>  25

Trp Val Arg Asp Ile Ile Asp Asp Phe Thr Asn Glu Ser Ser Gln Lys 
1               5                   10                  15      


Thr 
    


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide containing Diphtheria Th epitope


<220>
<221>  PEPTIDE
<222>  (1)..(23)
<223>  Diphtheria Th

<400>  26

Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Val Ala Ala Leu Ser 
1               5                   10                  15      


Ile Leu Pro Gly His Gly Cys 
            20              


<210>  27
<211>  21
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Plasmodium falciparum Th

<400>  27

Asp His Glu Lys Lys His Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val Asn Ser 
            20      


<210>  28
<211>  17
<212>  PRT
<213>  Schistosoma mansoni


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Schistosoma mansoni Th

<400>  28

Lys Trp Phe Lys Thr Asn Ala Pro Asn Gly Val Asp Glu Lys His Arg 
1               5                   10                  15      


His 
    


<210>  29
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide containing Cholera Toxin Th epitope


<220>
<221>  PEPTIDE
<222>  (1)..(25)
<223>  Cholera Toxin Th

<400>  29

Ala Leu Asn Ile Trp Asp Arg Phe Asp Val Phe Cys Thr Leu Gly Ala 
1               5                   10                  15      


Thr Thr Gly Tyr Leu Lys Gly Asn Ser 
            20                  25  


<210>  30
<211>  15
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  MvF 2 Th

<400>  30

Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Gly Ile 
1               5                   10                  15  


<210>  31
<211>  22
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  KKKMvF 3 Th

<220>
<221>  SITE
<222>  (7)..(7)
<223>  S or T

<220>
<221>  SITE
<222>  (10)..(10)
<223>  K or R

<220>
<221>  SITE
<222>  (11)..(11)
<223>  G or T

<220>
<221>  SITE
<222>  (15)..(15)
<223>  H or T

<220>
<221>  SITE
<222>  (16)..(16)
<223>  K or R

<220>
<221>  SITE
<222>  (19)..(19)
<223>  G or T

<400>  31

Lys Lys Lys Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa 
1               5                   10                  15      


Ile Glu Xaa Ile Leu Phe 
            20          


<210>  32
<211>  18
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  HBsAg 1 Th

<220>
<221>  SITE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  SITE
<222>  (2)..(2)
<223>  K or R

<220>
<221>  SITE
<222>  (3)..(3)
<223>  K or R

<220>
<221>  SITE
<222>  (4)..(4)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (5)..(5)
<223>  F or K or R

<220>
<221>  SITE
<222>  (6)..(6)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (7)..(7)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (9)..(9)
<223>  K or R

<220>
<221>  SITE
<222>  (10)..(10)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (11)..(11)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (13)..(13)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Q or L or I or V or F

<220>
<221>  SITE
<222>  (17)..(17)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (18)..(18)
<223>  D or R

<400>  32

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Xaa Xaa Thr Xaa Pro Xaa Ser 
1               5                   10                  15      


Xaa Xaa 
        


<210>  33
<211>  19
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<400>  33

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe 
            


<210>  34
<211>  18
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  HBsAg 2 Th

<220>
<221>  SITE
<222>  (4)..(4)
<223>  I or F

<220>
<221>  SITE
<222>  (5)..(5)
<223>  I or F

<220>
<221>  SITE
<222>  (6)..(6)
<223>  T or L

<220>
<221>  SITE
<222>  (7)..(7)
<223>  I or L

<220>
<221>  SITE
<222>  (11)..(11)
<223>  I or L

<220>
<221>  SITE
<222>  (14)..(14)
<223>  P or I

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Q or T

<220>
<221>  SITE
<222>  (16)..(16)
<223>  S or T

<220>
<221>  SITE
<222>  (17)..(17)
<223>  L or I

<400>  34

Lys Lys Lys Xaa Xaa Xaa Xaa Thr Arg Ile Xaa Thr Ile Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Asp 
        


<210>  35
<211>  19
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th

<400>  35

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe 
            


<210>  36
<211>  18
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  HBsAg 3 Th

<400>  36

Lys Lys Lys Ile Ile Thr Ile Thr Arg Ile Ile Thr Ile Ile Thr Thr 
1               5                   10                  15      


Ile Asp 
        


<210>  37
<211>  11
<212>  PRT
<213>  Influenza virus


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Influenza Matrix protein 1 _1 Th

<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Influenza Matrix protein 1_1 Th

<400>  37

Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg 
1               5                   10      


<210>  38
<211>  15
<212>  PRT
<213>  Influenza virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Influenza Matrix protein 1_2 Th

<400>  38

Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val 
1               5                   10                  15  


<210>  39
<211>  9
<212>  PRT
<213>  Influenza virus


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Influenza Non-structural protein 1 Th

<400>  39

Asp Arg Leu Arg Arg Asp Gln Lys Ser 
1               5                   


<210>  40
<211>  19
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  EBV BHRF1 Th

<400>  40

Ala Gly Leu Thr Leu Ser Leu Leu Val Ile Cys Ser Tyr Leu Phe Ile 
1               5                   10                  15      


Ser Arg Gly 
            


<210>  41
<211>  15
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Clostridium tetani TT1 Th

<400>  41

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  42
<211>  20
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(20)
<223>  EBV EBNA-1 Th

<400>  42

Pro Gly Pro Leu Arg Glu Ser Ile Val Cys Tyr Phe Met Val Phe Leu 
1               5                   10                  15      


Gln Thr His Ile 
            20  


<210>  43
<211>  21
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Clostridium tetani  TT2 Th

<400>  43

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  44
<211>  16
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Clostridium tetani TT3 Th

<400>  44

Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe 
1               5                   10                  15      


<210>  45
<211>  16
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Clostridium tetani  TT4 Th

<400>  45

Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys 
1               5                   10                  15      


<210>  46
<211>  18
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  EBV CP Th

<400>  46

Val Pro Gly Leu Tyr Ser Pro Cys Arg Ala Phe Phe Asn Lys Glu Glu 
1               5                   10                  15      


Leu Leu 
        


<210>  47
<211>  14
<212>  PRT
<213>  Human cytomegalovirus


<220>
<221>  PEPTIDE
<222>  (1)..(14)
<223>  HCMV IE1 Th

<400>  47

Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys Glu Leu His 
1               5                   10                  


<210>  48
<211>  15
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  EBV GP340 Th

<400>  48

Thr Gly His Gly Ala Arg Thr Ser Thr Glu Pro Thr Thr Asp Tyr 
1               5                   10                  15  


<210>  49
<211>  13
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  EBV BPLF1 Th

<400>  49

Lys Glu Leu Lys Arg Gln Tyr Glu Lys Lys Leu Arg Gln 
1               5                   10              


<210>  50
<211>  11
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  EBV EBNA-2 Th

<400>  50

Thr Val Phe Tyr Asn Ile Pro Pro Met Pro Leu 
1               5                   10      


<210>  51
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  pTau 145-P160  (pT149/pT153)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  PHOSPHORYLATION

<400>  51

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Asp Gly Lys Thr Lys Ile Ala Thr 
            20                  25                  30          


Pro Arg Gly Ala Ala Pro Pro 
        35                  


<210>  52
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  Tau 145-160

<400>  52

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Asp Gly Lys Thr Lys Ile Ala Thr 
            20                  25                  30          


Pro Arg Gly Ala Ala Pro Pro 
        35                  


<210>  53
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  pTau 172-189 (pT175/pT181/pS185)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  PHOSPHORYLATION

<400>  53

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Pro Ala Lys Thr Pro Pro Ala Pro Lys 
            20                  25                  30          


Thr Pro Pro Ser Ser Gly Glu Pro Pro 
        35                  40      


<210>  54
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  Tau 172-189

<400>  54

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Pro Ala Lys Thr Pro Pro Ala Pro Lys 
            20                  25                  30          


Thr Pro Pro Ser Ser Gly Glu Pro Pro 
        35                  40      


<210>  55
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(42)
<223>  pTau 182-200 (pS184/pY197)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  PHOSPHORYLATION

<400>  55

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Pro Pro Ser Ser Gly Glu Pro Pro Lys 
            20                  25                  30          


Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
        35                  40          


<210>  56
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(42)
<223>  Tau 182-200

<400>  56

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Pro Pro Ser Ser Gly Glu Pro Pro Lys 
            20                  25                  30          


Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
        35                  40          


<210>  57
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(42)
<223>  pTau 195-213  (pS199/pS202/pT205)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  PHOSPHORYLATION

<400>  57

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
            20                  25                  30          


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
        35                  40          


<210>  58
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(42)
<223>  Tau 195-213

<400>  58

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
            20                  25                  30          


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
        35                  40          


<210>  59
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(42)
<223>  pTau 195-213 (pS198/pS208/pS210)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  PHOSPHORYLATION

<400>  59

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
            20                  25                  30          


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
        35                  40          


<210>  60
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  pTau 209-224 (pT212/pS214/pT217)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  PHOSPHORYLATION

<400>  60

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Arg Ser Arg Thr Pro Thr Pro Gly Ser 
            20                  25                  30          


Arg Ser Arg Thr Pro Ser Leu 
        35                  


<210>  61
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  Tau 209-224

<400>  61

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Arg Ser Arg Thr Pro Thr Pro Gly Ser 
            20                  25                  30          


Arg Ser Arg Thr Pro Ser Leu 
        35                  


<210>  62
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  pTau 228-243 (pT231/pS235/pS238)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  PHOSPHORYLATION

<400>  62

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Val Arg Thr Pro Pro Lys Ser Pro 
            20                  25                  30          


Ser Ser Ala Lys Ser Arg Leu 
        35                  


<210>  63
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  Tau 228-243

<400>  63

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Val Arg Thr Pro Pro Lys Ser Pro 
            20                  25                  30          


Ser Ser Ala Lys Ser Arg Leu 
        35                  


<210>  64
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  pTau 257-274 (pS262)

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  PHOSPHORYLATION

<400>  64

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Ser Lys Ile Gly Ser Thr Glu Asn 
            20                  25                  30          


Leu Lys His Gln Pro Gly Gly Gly Lys 
        35                  40      


<210>  65
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  Tau 257-274

<400>  65

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Ser Lys Ile Gly Ser Thr Glu Asn 
            20                  25                  30          


Leu Lys His Gln Pro Gly Gly Gly Lys 
        35                  40      


<210>  66
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(53)
<223>  pTau 379-408 (pS396/pS404)

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (49)..(49)
<223>  PHOSPHORYLATION

<400>  66

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Arg Glu Asn Ala Lys Ala Lys Thr Asp 
            20                  25                  30          


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
        35                  40                  45              


Ser Pro Arg His Leu 
    50              


<210>  67
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(53)
<223>  Tau 379-408

<400>  67

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Arg Glu Asn Ala Lys Ala Lys Thr Asp 
            20                  25                  30          


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
        35                  40                  45              


Ser Pro Arg His Leu 
    50              


<210>  68
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(60)
<223>  pTau 275-311 (*P301->S301; pS293/pS301)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (50)..(50)
<223>  PHOSPHORYLATION

<400>  68

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            20                  25                  30          


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        35                  40                  45              


Val Ser Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
    50                  55                  60  


<210>  69
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(60)
<223>  Tau 275-311

<400>  69

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            20                  25                  30          


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        35                  40                  45              


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
    50                  55                  60  


<210>  70
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(56)
<223>  pTau 393-425 (pS396/pS404/pS422)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  PHOSPHORYLATION

<220>
<221>  MOD_RES
<222>  (53)..(53)
<223>  PHOSPHORYLATION

<400>  70

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Tyr Lys Ser Pro Val Val Ser Gly 
            20                  25                  30          


Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile 
        35                  40                  45              


Asp Met Val Asp Ser Pro Gln Leu 
    50                  55      


<210>  71
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(56)
<223>  Tau 393-425

<400>  71

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Tyr Lys Ser Pro Val Val Ser Gly 
            20                  25                  30          


Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile 
        35                  40                  45              


Asp Met Val Asp Ser Pro Gln Leu 
    50                  55      


<210>  72
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  Tau peptide, L215-V226

<400>  72

Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
1               5                   10          


<210>  73
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  Tau peptide, T205-V226

<400>  73

Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
1               5                   10                  15      


Arg Glu Pro Lys Lys Val 
            20          


<210>  74
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  Tau peptide, S195-V226

<400>  74

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
            20                  25                  30          


<210>  75
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(42)
<223>  Tau peptide, S185-V226

<400>  75

Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
1               5                   10                  15      


Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
            20                  25                  30          


Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
        35                  40          


<210>  76
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(52)
<223>  Tau peptide, T175-V226

<400>  76

Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys 
1               5                   10                  15      


Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro 
            20                  25                  30          


Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu 
        35                  40                  45              


Pro Lys Lys Val 
    50          


<210>  77
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(62)
<223>  Tau peptide, Q165-V226

<400>  77

Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys 
1               5                   10                  15      


Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly 
            20                  25                  30          


Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr 
        35                  40                  45              


Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val 
    50                  55                  60          


<210>  78
<211>  72
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(72)
<223>  Tau peptide, R155-V226

<400>  78

Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
1               5                   10                  15      


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
            20                  25                  30          


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
        35                  40                  45              


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
    50                  55                  60                  


Pro Thr Arg Glu Pro Lys Lys Val 
65                  70          


<210>  79
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  Tau peptide, V287-K298

<400>  79

Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
1               5                   10          


<210>  80
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  Tau peptide, I277-K298

<400>  80

Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly 
1               5                   10                  15      


Ser Lys Asp Asn Ile Lys 
            20          


<210>  81
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  Tau peptide, K267-K298

<400>  81

Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
1               5                   10                  15      


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
            20                  25                  30          


<210>  82
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(42)
<223>  Tau peptide, K257-K298

<400>  82

Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
1               5                   10                  15      


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
            20                  25                  30          


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
        35                  40          


<210>  83
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(52)
<223>  Tau peptide, P247-K298

<400>  83

Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser 
1               5                   10                  15      


Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile 
            20                  25                  30          


Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
        35                  40                  45              


Asp Asn Ile Lys 
    50          


<210>  84
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(62)
<223>  Tau peptide, S237-K298

<400>  84

Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp 
1               5                   10                  15      


Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His 
            20                  25                  30          


Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu 
        35                  40                  45              


Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
    50                  55                  60          


<210>  85
<211>  72
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(72)
<223>  Tau peptide, A227-K298

<400>  85

Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg 
1               5                   10                  15      


Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
            20                  25                  30          


Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys 
        35                  40                  45              


Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
    50                  55                  60                  


Cys Gly Ser Lys Asp Asn Ile Lys 
65                  70          


<210>  86
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  Tau peptide, N359-K370

<400>  86

Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
1               5                   10          


<210>  87
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  Tau peptide, R349-K370

<400>  87

Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
1               5                   10                  15      


Gly Gly Gly Asn Lys Lys 
            20          


<210>  88
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  Tau peptide, V339-K370

<400>  88

Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
1               5                   10                  15      


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
            20                  25                  30          


<210>  89
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(42)
<223>  Tau peptide, H329-K370

<400>  89

His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
1               5                   10                  15      


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
            20                  25                  30          


Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        35                  40          


<210>  90
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(52)
<223>  Tau peptide, T319-K370

<400>  90

Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly 
1               5                   10                  15      


Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val 
            20                  25                  30          


Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly 
        35                  40                  45              


Gly Asn Lys Lys 
    50          


<210>  91
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(62)
<223>  Tau peptide, V309-K370

<400>  91

Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser 
1               5                   10                  15      


Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys 
            20                  25                  30          


Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser 
        35                  40                  45              


Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
    50                  55                  60          


<210>  92
<211>  72
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(72)
<223>  Tau peptide, H299-K370

<400>  92

His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
1               5                   10                  15      


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            20                  25                  30          


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        35                  40                  45              


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    50                  55                  60                  


Val Pro Gly Gly Gly Asn Lys Lys 
65                  70          


<210>  93
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Tau peptide, E431-L441

<400>  93

Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
1               5                   10      


<210>  94
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Tau peptide, D421-L441

<400>  94

Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu 
1               5                   10                  15      


Ala Lys Gln Gly Leu 
            20      


<210>  95
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  Tau peptide, V411-L441

<400>  95

Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
1               5                   10                  15      


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            20                  25                  30      


<210>  96
<211>  41
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(41)
<223>  Tau peptide, G401-L441

<400>  96

Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
1               5                   10                  15      


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            20                  25                  30          


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        35                  40      


<210>  97
<211>  51
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(51)
<223>  Tau peptide, E391-L441

<400>  97

Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg 
1               5                   10                  15      


His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser 
            20                  25                  30          


Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys 
        35                  40                  45              


Gln Gly Leu 
    50      


<210>  98
<211>  61
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(61)
<223>  Tau peptide, N381-L441

<400>  98

Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
1               5                   10                  15      


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            20                  25                  30          


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        35                  40                  45              


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    50                  55                  60      


<210>  99
<211>  71
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(71)
<223>  Tau peptide, I371-L441

<400>  99

Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr 
1               5                   10                  15      


Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp 
            20                  25                  30          


Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp 
        35                  40                  45              


Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala 
    50                  55                  60                  


Ser Leu Ala Lys Gln Gly Leu 
65                  70      


<210>  100
<211>  441
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(441)
<223>  Tau isoform with 4R and 2N (GenBank: AGF19246.1)

<400>  100

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  101
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Tau peptide - aa131-141

<400>  101

Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
1               5                   10      


<210>  102
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Tau peptide - aa241-257

<400>  102

Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
1               5                   10                  15      


Lys 
    


<210>  103
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Tau peptide - aa243-259

<400>  103

Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser 
1               5                   10                  15      


Lys 
    


<210>  104
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(7)
<223>  Tau peptide - aa275-281

<400>  104

Val Gln Ile Ile Asn Lys Lys 
1               5           


<210>  105
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(14)
<223>  Tau peptide - aa281-294

<400>  105

Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
1               5                   10                  


<210>  106
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(20)
<223>  Tau peptide - aa275-294

<400>  106

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys 
            20  


<210>  107
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  Tau peptide - aa294-311

<400>  107

Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val 
1               5                   10                  15      


Tyr Lys 
        


<210>  108
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  Tau peptide - aa294-311, P301 to S301

<400>  108

Lys Asp Asn Ile Lys His Val Ser Gly Gly Gly Ser Val Gln Ile Val 
1               5                   10                  15      


Tyr Lys 
        


<210>  109
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  Tau peptide - aa294-311, p301 trans

<400>  109

Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val 
1               5                   10                  15      


Tyr Lys 
        


<210>  110
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(37)
<223>  Tau peptide - aa275-311, p301 trans

<400>  110

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30          


Gln Ile Val Tyr Lys 
        35          


<210>  111
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Tau peptide - aa297-311, p301 trans

<400>  111

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
1               5                   10                  15  


<210>  112
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  Tau peptide - aa22-34

<400>  112

Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln Asp 
1               5                   10              


<210>  113
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Tau peptide - aa18-34

<400>  113

Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln 
1               5                   10                  15      


Asp 
    


<210>  114
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Tau peptide - aa22-38

<400>  114

Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly 
1               5                   10                  15      


Asp 
    


<210>  115
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Tau peptide - aa297-311

<400>  115

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
1               5                   10                  15  


<210>  116
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(12)
<223>  Tau peptide - aa359-370

<400>  116

Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
1               5                   10          


<210>  117
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  Tau peptide - aa349-370

<400>  117

Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
1               5                   10                  15      


Gly Gly Gly Asn Lys Lys 
            20          


<210>  118
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(32)
<223>  Tau peptide - aa339-370

<400>  118

Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
1               5                   10                  15      


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
            20                  25                  30          


<210>  119
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(42)
<223>  Tau peptide - aa329-370

<400>  119

His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
1               5                   10                  15      


Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
            20                  25                  30          


Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        35                  40          


<210>  120
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Tau peptide - aa329-349

<400>  120

His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu 
1               5                   10                  15      


Asp Phe Lys Asp Arg 
            20      


<210>  121
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  Tau peptide - aa1-40

<400>  121

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp 
        35                  40  


<210>  122
<211>  40
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  Tau peptide - aa11-50

<400>  122

Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln 
1               5                   10                  15      


Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly 
            20                  25                  30          


Leu Lys Glu Ser Pro Leu Gln Thr 
        35                  40  


<210>  123
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Tau peptide - aa1-34

<400>  123

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp 
        


<210>  124
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  Tau peptide - aa1-22

<400>  124

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp 
            20          


<210>  125
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(34)
<223>  Tau S131-K141

<400>  125

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp 
            20                  25                  30          


Lys Lys 
        


<210>  126
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(40)
<223>  Tau S241-K257

<400>  126

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
            20                  25                  30          


Met Pro Asp Leu Lys Asn Val Lys 
        35                  40  


<210>  127
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(40)
<223>  Tau L243-K259

<400>  127

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Gln Thr Ala Pro Val Pro Met Pro 
            20                  25                  30          


Asp Leu Lys Asn Val Lys Ser Lys 
        35                  40  


<210>  128
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(30)
<223>  Tau V275-K281

<400>  128

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Gln Ile Ile Asn Lys Lys 
            20                  25                  30  


<210>  129
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(37)
<223>  Tau K281-K294

<400>  129

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Leu Asp Leu Ser Asn Val Gln Ser 
            20                  25                  30          


Lys Cys Gly Ser Lys 
        35          


<210>  130
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(43)
<223>  Tau V275-K294

<400>  130

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            20                  25                  30          


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
        35                  40              


<210>  131
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  Tau K294-K311

<400>  131

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Asp Asn Ile Lys His Val Pro Gly 
            20                  25                  30          


Gly Gly Ser Val Gln Ile Val Tyr Lys 
        35                  40      


<210>  132
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  Tau K294-K311, P301 to S301

<400>  132

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Asp Asn Ile Lys His Val Ser Gly 
            20                  25                  30          


Gly Gly Ser Val Gln Ile Val Tyr Lys 
        35                  40      


<210>  133
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  Tau K257-K274

<400>  133

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Ser Lys Ile Gly Ser Thr Glu Asn 
            20                  25                  30          


Leu Lys His Gln Pro Gly Gly Gly Lys 
        35                  40      


<210>  134
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(53)
<223>  Tau R379-L408

<400>  134

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Arg Glu Asn Ala Lys Ala Lys Thr Asp 
            20                  25                  30          


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
        35                  40                  45              


Ser Pro Arg His Leu 
    50              


<210>  135
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  Tau K294-K311, p301 trans

<400>  135

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Lys Asp Asn Ile Lys His Val Pro Gly 
            20                  25                  30          


Gly Gly Ser Val Gln Ile Val Tyr Lys 
        35                  40      


<210>  136
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(60)
<223>  Tau V275-K311, p301 trans

<400>  136

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            20                  25                  30          


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        35                  40                  45              


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
    50                  55                  60  


<210>  137
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(36)
<223>  Tau D22-D34

<400>  137

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Asp Arg Lys Asp Gln Gly Gly Tyr Thr 
            20                  25                  30          


Met His Gln Asp 
        35      


<210>  138
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(40)
<223>  Tau Y18-D34

<400>  138

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Gly Leu Gly Asp Arg Lys Asp Gln 
            20                  25                  30          


Gly Gly Tyr Thr Met His Gln Asp 
        35                  40  


<210>  139
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(40)
<223>  Tau D22-D38

<400>  139

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Asp Arg Lys Asp Gln Gly Gly Tyr Thr 
            20                  25                  30          


Met His Gln Asp Gln Glu Gly Asp 
        35                  40  


<210>  140
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(38)
<223>  Tau I297-K311, p301 trans

<400>  140

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ile Val Tyr Lys 
        35              


<210>  141
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Tau I297-K311

<220>
<221>  SITE
<222>  (16)..(16)
<223>  epsilon K

<220>
<221>  PEPTIDE
<222>  (16)..(19)
<223>  KKK-epsilon K as a spacer

<220>
<221>  PEPTIDE
<222>  (20)..(38)
<223>  MvF5 Th (UBITh1)

<400>  141

Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Lys 
1               5                   10                  15      


Lys Lys Lys Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg 
            20                  25                  30          


Ile Glu Thr Ile Leu Phe 
        35              


<210>  142
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (21)..(38)
<223>  Tau K294-K311

<400>  142

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ile Val Tyr Lys 
        35              


<210>  143
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (21)..(35)
<223>  Tau I297-K311

<400>  143

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile 
            20                  25                  30          


Val Tyr Lys 
        35  


<210>  144
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(38)
<223>  Tau I297-K311

<400>  144

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ile Val Tyr Lys 
        35              


<210>  145
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(39)
<223>  Tau A145-P160

<400>  145

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Asp Gly Lys Thr Lys Ile Ala Thr 
            20                  25                  30          


Pro Arg Gly Ala Ala Pro Pro 
        35                  


<210>  146
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(60)
<223>  Tau V275-K311

<400>  146

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            20                  25                  30          


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        35                  40                  45              


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
    50                  55                  60  


<210>  147
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(35)
<223>  Tau N359-K370

<400>  147

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Asn Ile Thr His Val Pro Gly Gly Gly 
            20                  25                  30          


Asn Lys Lys 
        35  


<210>  148
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(45)
<223>  Tau R349-K370

<400>  148

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Arg Val Gln Ser Lys Ile Gly Ser Leu 
            20                  25                  30          


Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
        35                  40                  45  


<210>  149
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(55)
<223>  Tau V339-K370

<400>  149

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Val Lys Ser Glu Lys Leu Asp Phe Lys 
            20                  25                  30          


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
        35                  40                  45              


Pro Gly Gly Gly Asn Lys Lys 
    50                  55  


<210>  150
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(65)
<223>  Tau H329-K370

<400>  150

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
        35                  40                  45              


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
    50                  55                  60                  


Lys 
65  


<210>  151
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(44)
<223>  Tau H329-R349

<400>  151

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30          


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
        35                  40                  


<210>  152
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  Tau M1-D40

<220>
<221>  SITE
<222>  (41)..(41)
<223>  epsilon K

<220>
<221>  PEPTIDE
<222>  (41)..(44)
<223>  KKK-epsilon K as a spacer

<220>
<221>  PEPTIDE
<222>  (45)..(63)
<223>  MvF5 Th (UBITh1)

<400>  152

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Lys Lys Lys Lys Ile Ser Ile Thr 
        35                  40                  45              


Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr Ile Leu Phe 
    50                  55                  60              


<210>  153
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(40)
<223>  Tau M11-T50

<220>
<221>  SITE
<222>  (41)..(41)
<223>  epsilon K

<220>
<221>  PEPTIDE
<222>  (41)..(44)
<223>  KKK-epsilon K as a spacer

<220>
<221>  PEPTIDE
<222>  (45)..(63)
<223>  MvF5 Th (UBITh1)

<400>  153

Met Glu Asp His Ala Gly Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln 
1               5                   10                  15      


Gly Gly Tyr Thr Met His Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly 
            20                  25                  30          


Leu Lys Glu Ser Pro Leu Gln Thr Lys Lys Lys Lys Ile Ser Ile Thr 
        35                  40                  45              


Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr Ile Leu Phe 
    50                  55                  60              


<210>  154
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(34)
<223>  Tau M1-D34

<220>
<221>  SITE
<222>  (35)..(35)
<223>  epsilon K

<220>
<221>  PEPTIDE
<222>  (35)..(38)
<223>  KKK-epsilon K as a spacer

<220>
<221>  PEPTIDE
<222>  (39)..(57)
<223>  MvF5 Th (UBITh1)

<400>  154

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Lys Lys Lys Lys Ile Ser Ile Thr Glu Ile Lys Gly Val Ile 
        35                  40                  45              


Val His Arg Ile Glu Thr Ile Leu Phe 
    50                  55          


<210>  155
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  Tau M1-D22

<220>
<221>  SITE
<222>  (23)..(23)
<223>  epsilon K

<220>
<221>  PEPTIDE
<222>  (23)..(26)
<223>  KKK-epsilon K as a spacer

<220>
<221>  PEPTIDE
<222>  (27)..(45)
<223>  MvF5 Th (UBITh1)

<400>  155

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Lys Lys Lys Lys Ile Ser Ile Thr Glu Ile 
            20                  25                  30          


Lys Gly Val Ile Val His Arg Ile Glu Thr Ile Leu Phe 
        35                  40                  45  


<210>  156
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  Tau peptide - aa281-311

<400>  156

Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn 
1               5                   10                  15      


Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
            20                  25                  30      


<210>  157
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(29)
<223>  Tau peptide - aa283-311

<400>  157

Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
1               5                   10                  15      


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
            20                  25                  


<210>  158
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(27)
<223>  Tau peptide - aa285-311

<400>  158

Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val 
1               5                   10                  15      


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
            20                  25          


<210>  159
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(25)
<223>  Tau peptide - aa287-311

<400>  159

Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly 
1               5                   10                  15      


Gly Gly Ser Val Gln Ile Val Tyr Lys 
            20                  25  


<210>  160
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(23)
<223>  Tau peptide - aa289-311

<400>  160

Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
1               5                   10                  15      


Ser Val Gln Ile Val Tyr Lys 
            20              


<210>  161
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Tau peptide - aa291-311

<400>  161

Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
1               5                   10                  15      


Gln Ile Val Tyr Lys 
            20      


<210>  162
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Tau peptide - aa293-311

<400>  162

Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile 
1               5                   10                  15      


Val Tyr Lys 
            


<210>  163
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Tau peptide - aa295-311

<400>  163

Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
1               5                   10                  15      


Lys 
    


<210>  164
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  Tau peptide - aa299-311

<400>  164

His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
1               5                   10              


<210>  165
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Tau peptide - aa301-311

<400>  165

Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
1               5                   10      


<210>  166
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  Tau peptide - aa275-305

<400>  166

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser 
            20                  25                  30      


<210>  167
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(27)
<223>  Tau peptide - aa275-301

<400>  167

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            20                  25          


<210>  168
<211>  23
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(23)
<223>  Tau peptide - aa275-297

<400>  168

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser Lys Asp Asn Ile 
            20              


<210>  169
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  Tau peptide - aa275-293

<400>  169

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys 
1               5                   10                  15      


Cys Gly Ser 
            


<210>  170
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Tau peptide - aa275-289

<400>  170

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser 
1               5                   10                  15  


<210>  171
<211>  11
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Tau peptide - aa275-285

<400>  171

Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
1               5                   10      


