                         SEQUENCE LISTING

<110>  Children's Medical Center Corporation
       President & Fellows of Harvard College
 
<120>  METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION 
       WITH IMMUNOTHERAPY

<130>  37314-0064WO1

<150>  US 62/688,002
<151>  2018-06-21

<150>  US 62/576,001
<151>  2017-10-23

<160>  157   

<170>  PatentIn version 3.5

<210>  1
<211>  2631
<212>  DNA
<213>  Homo sapiens

<400>  1
atgttatctg ggaagaaggc ggcagccgcg gcggcggcgg ctgcagcggc agcaaccggg       60

acggaggctg gccctgggac agcaggcggc tccgagaacg ggtctgaggt ggccgcgcag      120

cccgcgggcc tgtcgggccc agccgaggtc gggccggggg cggtggggga gcgcacaccc      180

cgcaagaaag agcctccgcg ggcctcgccc cccgggggcc tggcggaacc gccggggtcc      240

gcagggcctc aggccggccc tactgtcgtg cctgggtctg cgacccccat ggaaactgga      300

atagcagaga ctccggaggg gcgtcggacc agccggcgca agcgggcgaa ggtagagtac      360

agagagatgg atgaaagctt ggccaacctc tcagaagatg agtattattc agaagaagag      420

agaaatgcca aagcagagaa ggaaaagaag cttcccccac caccccctca agccccacct      480

gaggaagaaa atgaaagtga gcctgaagaa ccatcggggc aagcaggagg acttcaagac      540

gacagttctg gagggtatgg agacggccaa gcatcaggtg tggagggcgc agctttccag      600

agccgacttc ctcatgaccg gatgacttct caagaagcag cctgttttcc agatattatc      660

agtggaccac aacagaccca gaaggttttt cttttcatta gaaaccgcac actgcagttg      720

tggttggata atccaaagat tcagctgaca tttgaggcta ctctccaaca attagaagca      780

ccttataaca gtgatactgt gcttgtccac cgagttcaca gttatttaga gcgtcatggt      840

cttatcaact tcggcatcta taagaggata aaacccctac caactaaaaa gacaggaaag      900

gtaattatta taggctctgg ggtctcaggc ttggcagcag ctcgacagtt acaaagtttt      960

ggaatggatg tcacactttt ggaagccagg gatcgtgtgg gtggacgagt tgccacattt     1020

cgcaaaggaa actatgtagc tgatcttgga gccatggtgg taacaggtct tggagggaat     1080

cctatggctg tggtcagcaa acaagtaaat atggaactgg ccaagatcaa gcaaaaatgc     1140

ccactttatg aagccaacgg acaagctgac actgtcaagg ttcctaaaga gaaagatgaa     1200

atggtagagc aagagtttaa ccggttgcta gaagctacat cttaccttag tcatcaacta     1260

gacttcaatg tcctcaataa taagcctgtg tcccttggcc aggcattgga agttgtcatt     1320

cagttacaag agaagcatgt caaagatgag cagattgaac attggaagaa gatagtgaaa     1380

actcaggaag aattgaaaga acttcttaat aagatggtaa atttgaaaga gaaaattaaa     1440

gaactccatc agcaatacaa agaagcatct gaagtaaagc cacccagaga tattactgcc     1500

gagttcttag tgaaaagcaa acacagggat ctgaccgccc tatgcaagga atatgatgaa     1560

ttagctgaaa cacaaggaaa gctagaagaa aaacttcagg agttggaagc gaatccccca     1620

agtgatgtat atctctcatc aagagacaga caaatacttg attggcattt tgcaaatctt     1680

gaatttgcta atgccacacc tctctcaact ctctccctta agcactggga tcaggatgat     1740

gactttgagt tcactggcag ccacctgaca gtaaggaatg gctactcgtg tgtgcctgtg     1800

gctttagcag aaggcctaga cattaaactg aatacagcag tgcgacaggt tcgctacacg     1860

gcttcaggat gtgaagtgat agctgtgaat acccgctcca cgagtcaaac ctttatttat     1920

aaatgcgacg cagttctctg tacccttccc ctgggtgtgc tgaagcagca gccaccagcc     1980

gttcagtttg tgccacctct ccctgagtgg aaaacatctg cagtccaaag gatgggattt     2040

ggcaacctta acaaggtggt gttgtgtttt gatcgggtgt tctgggatcc aagtgtcaat     2100

ttgttcgggc atgttggcag tacgactgcc agcaggggtg agctcttcct cttctggaac     2160

ctctataaag ctccaatact gttggcacta gtggcaggag aagctgctgg tatcatggaa     2220

aacataagtg acgatgtgat tgttggccga tgcctggcca ttctcaaagg gatttttggt     2280

agcagtgcag tacctcagcc caaagaaact gtggtgtctc gttggcgtgc tgatccctgg     2340

gctcggggct cttattccta tgttgctgca ggatcatctg gaaatgacta tgatttaatg     2400

gctcagccaa tcactcctgg cccctcgatt ccaggtgccc cacagccgat tccacgactc     2460

ttctttgcgg gagaacatac gatccgtaac tacccagcca cagtgcatgg tgctctgctg     2520

agtgggctgc gagaagcggg aagaattgca gaccagtttt tgggggccat gtatacgctg     2580

cctcgccagg ccacaccagg tgttcctgca cagcagtccc caagcatgtg a              2631


<210>  2
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human LSD1

<400>  2
ccgggcctag acattaaact gaatactcga gtattcagtt taatgtctag gctttttg         58


<210>  3
<211>  867
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  4
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human PD-1

<400>  4
ccggcattgt ctttcctagc ggaatctcga gattccgcta ggaaagacaa tgtttttg         58


<210>  5
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873


<210>  6
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ShRNA targeting human PD-L1

<400>  6
ccggctgaca ttcatcttcc gtttactcga gtaaacggaa gatgaatgtc agtttttg         58


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ShRNA targeting human PD-L1

<400>  7
gcaagctgac cctgaagttc at                                                22


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GCAAGCTGACCCTGAAGTTCAT

<400>  8
cctaaggtta agtcgccctc g                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Scrambled shRNA sequence

<400>  9
gcctagacat taaactgaat a                                                 21


<210>  10
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human TLR3

<400>  10
ccttacacat actcaacct                                                    19


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human MDA5

<400>  11
ccaacaaaga agcagtgtat a                                                 21


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human RIG-I

<400>  12
aattcatcag agatagtca                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human MAVS

<400>  13
gcatctcttc aataccctt                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human MAVS

<400>  14
ggagagaatt cagagcaag                                                    19


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human cGAS

<400>  15
atctattctc tagcaactta a                                                 21


<210>  16
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human STING

<400>  16
gcatggtcat attacatcg                                                    19


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA targeting human AGO2

<400>  17
gcacagccag taatcgagtt t                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 1 targeting human DICER

<400>  18
aagaatcagc ctcgcaacaa a                                                 21


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 4 targeting human DICER

<400>  19
tctattagca ccttgatgt                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 1 targeting human TRBP2

<400>  20
gctgcctagt atagagcaa                                                    19


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 2 targeting human TRBP2

<400>  21
tctacgaaat tcagtagga                                                    19


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 4 targeting human TRBP2

<400>  22
ggattctcta cgaaattca                                                    19


<210>  23
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 1 targeting mouse LSD1

<400>  23
cacaaggaaa gctagaaga                                                    19


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 2 targeting mouse LSD1

<400>  24
ggatgggatt tggcaacctt a                                                 21


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 3 targeting mouse LSD1

<400>  25
aactccatgt catcagctac t                                                 21


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA 4 targeting mouse LSD1

<400>  26
cggcatctac aagaggataa a                                                 21


<210>  27
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  27
atattcatct tctgagaggt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  28
tcttcctcag gtggggcttg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  29
cctgagaggt cattcggtca                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  30
ccatgaccga atgacctctc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  31
ggcagggatt caggcaccat                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human GAPDH

<400>  32
aacgggaagc ttgtcatcaa                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human GAPDH

<400>  33
tggactccac gacgtactca                                                   20


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human LSD1

<400>  34
gtggacgagt tgccacattt c                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human LSD1

<400>  35
tgaccacagc cataggattc c                                                 21


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human HERV-E

<400>  36
ggtgtcacta ctcaatacac                                                   20


<210>  37
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human HERV-E

<400>  37
gcagcctagg tctctgg                                                      17


<210>  38
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human HERV-F

<400>  38
cctccagtca caacaactc                                                    19


<210>  39
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human HERV-F

<400>  39
tattgaagaa ggcggctgg                                                    19


<210>  40
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human HERV-K

<400>  40
attggcaaca ccgtattctg ct                                                22


<210>  41
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human HERV-K

<400>  41
cagtcaaaat atggacggat ggt                                               23


<210>  42
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human HML-2

<400>  42
aaagaaccag ccaccagg                                                     18


<210>  43
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human HML-2

<400>  43
cagtctgaaa acttttctct a                                                 21


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human ERVL

<400>  44
atatcctgcc tggatggggt                                                   20


<210>  45
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human ERVL

<400>  45
gagcttctta gtcctcctgt gt                                                22


<210>  46
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human Line 1

<400>  46
gccaagatgg ccgaatagg                                                    19


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human Line 1

<400>  47
tggcactccc tagtgagatg aa                                                22


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human AluYA5

<400>  48
accatcccgg ctaaaacggt ga                                                22


<210>  49
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human AluYA5

<400>  49
gcgatctcgg ctcactg                                                      17


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human IFN alpha

<400>  50
aatgacagaa ttcatgaaag cgt                                               23


<210>  51
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human IFN alpha

<400>  51
ggaggttgtc agagcaga                                                     18


<210>  52
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human IFN beta

<400>  52
gccatcagtc acttaaacag c                                                 21


<210>  53
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human IFN beta

<400>  53
gaaactgaag atctcctagc ct                                                22


<210>  54
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human IL-28a/b

<400>  54
tccagtcacg gtcagca                                                      17


<210>  55
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human IL-28a/b

<400>  55
cagcctcaga gtgtttcttc t                                                 21


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human OASL

<400>  56
gcagaaattt ccaggaccac                                                   20


<210>  57
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for sequence human OASL

<400>  57
cccatcacgg tcaccattg                                                    19


<210>  58
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human ISG15

<400>  58
ccttcagctc tgacacc                                                      17


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human ISG15

<400>  59
cgaactcatc tttgccagta ca                                                22


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human TLR3

<400>  60
tggttgggcc acctagaagt a                                                 21


<210>  61
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human TLR3

<400>  61
tctccattcc tggcctgtg                                                    19


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human MDA5

<400>  62
cacttccttc tgccaaactt g                                                 21


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human MDA5

<400>  63
gagcaacttc tttcaaccac ag                                                22


<210>  64
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human RIG-I

<400>  64
ccagcattac tagtcagaag gaa                                               23


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human RIG-I

<400>  65
cacagtgcaa tcttgtcatc c                                                 21


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human MAVS

<400>  66
aggagacaga tggagacaca                                                   20


<210>  67
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human MAVS

<400>  67
cagaactggg cagtaccc                                                     18


<210>  68
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human cGAS

<400>  68
taaccctggc tttggaatca aaa                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human cGAS

<400>  69
tgggtacaag gtaaaatggc ttt                                               23


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human STING

<400>  70
agcattacaa caacctgcta cg                                                22


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human STING

<400>  71
gttggggtca gccatactca g                                                 21


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for human AGO2

<400>  72
ccggccttct ctctggaaaa                                                   20


<210>  73
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for human AGO2

<400>  73
gccttgtaaa acgctgttgc t                                                 21


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse LSD1

<400>  74
gtggtgttat gctttgaccg t                                                 21


<210>  75
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse LSD1

<400>  75
gctgccaaaa atccctttga ga                                                22


<210>  76
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse ERV-L

<400>  76
tttctcaagg cccaccaata gt                                                22


<210>  77
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse ERV-L

<400>  77
gacacctttt ttaactatgc gagct                                             25


<210>  78
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse MusD

<400>  78
gattggtgga agtttagcta gcat                                              24


<210>  79
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse MusD

<400>  79
tagcattctc ataagccaat tgcat                                             25


<210>  80
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse IAP Pol

<400>  80
cttgccctta aaggtctaaa agca                                              24


<210>  81
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse IAP Pol

<400>  81
gcggtataag gtacaattaa aagatatgg                                         29


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse Line 1

<400>  82
tttgggacac aatgaaagca                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse Line 1

<400>  83
ctgccgtcta ctcctcttgg                                                   20


<210>  84
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse IFN alpha

<400>  84
cggtgctgag ctactggc                                                     18


<210>  85
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse IFN alpha

<400>  85
tttgtaccag gagtgtcaag g                                                 21


<210>  86
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse IFN beta

<400>  86
ggtggaatga gactattgtt g                                                 21


<210>  87
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse IFN beta

<400>  87
aggacatctc ccacgtc                                                      17


<210>  88
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse IL-28b

<400>  88
agctgcaggt ccaagagcg                                                    19


<210>  89
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse IL-28b

<400>  89
ggtggtcagg gctgagtcat t                                                 21


<210>  90
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse ISG15

<400>  90
ggtgtccgtg actaactcca t                                                 21


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse ISG15

<400>  91
tggaaagggt aagaccgtcc t                                                 21


<210>  92
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse OASL

<400>  92
caggagctgt acggcttcc                                                    19


<210>  93
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse OASL

<400>  93
cctaccttga gtaccttgag cac                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse TLR3

<400>  94
gtgagataca acgtagctga ctg                                               23


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse TLR3

<400>  95
tcctgcatcc aagatagcaa gt                                                22


<210>  96
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse RIG-I

<400>  96
aagagccaga gtgtcagaat ct                                                22


<210>  97
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for sequence mouse RIG-I

<400>  97
agctccagtt ggtaatttct tgg                                               23


<210>  98
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse beta actin

<400>  98
ggctgtattc ccctccatcg                                                   20


<210>  99
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse beta actin

<400>  99
ccagttggta acaatgccat gt                                                22


<210>  100
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for mouse GAPDH

<400>  100
tgacctcaac tacatggtct aca                                               23


<210>  101
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for mouse GAPDH

<400>  101
cttcccattc tcggccttg                                                    19


<210>  102
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer sequence for GFP-com

<400>  102
gaacggcatc aaggtgaact t                                                 21


<210>  103
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for GFPL

<400>  103
tagcgtaatc tggaacatcg tatgggt                                           27


<210>  104
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer sequence for GFP-let7

<400>  104
gacgacctcg agtgaggtag taggttgtat a                                      31


<210>  105
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Non-human Tag

<400>  105
gcacacgacg acagacgacg cac                                               23


<210>  106
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  106
gcacacgacg acagacgacg cacccagagt caggtgtcac tactcaatac ac               52


<210>  107
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  107
gcacacgacg acagacgacg cactactgga gcaacacgca gcctaggtct ctgg             54


<210>  108
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  108
ggtgtcacta ctcaatacac                                                   20


<210>  109
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  109
gcagcctagg tctctgg                                                      17


<210>  110
<211>  51
<212>  DNA
<213>  Homo sapiens

<400>  110
gcacacgacg acagacgacg cacgggaaga atgtgtggcc aatagtgcgg t                51


<210>  111
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  111
gcacacgacg acagacgacg cacggtagag attccttttt ctccccattc ccag             54


<210>  112
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  112
gtgtggccaa tagtgcggt                                                    19


<210>  113
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  113
attccttttt ctccccattc ccag                                              24


<210>  114
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  114
gcacacgacg acagacgacg cacatggagc ccaagatgca gtccaaga                    48


<210>  115
<211>  52
<212>  DNA
<213>  Homo sapiens

<400>  115
gcacacgacg acagacgacg cacctaactg cttcctgctg aattggggcg ta               52


<210>  116
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  116
atggagccca agatgcag                                                     18


<210>  117
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  117
ctaactgctt cctgctgaat tggggcgtag                                        30


<210>  118
<211>  50
<212>  DNA
<213>  Homo sapiens

<400>  118
gcacacgacg acagacgacg cacgctcgtc gtcgacaacg gctccggcat                  50


<210>  119
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  119
gcacacgacg acagacgacg caccaaacat gatctgggtc atcttctc                    48


<210>  120
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  120
gctcgtcgtc gacaacggct ccggca                                            26


<210>  121
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  121
caaacatgat ctgggtcatc ttctc                                             25


<210>  122
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA4-7

<400>  122
cactttcatt ttcttcctca ggtgggggct tga                                    33


<210>  123
<211>  32
<212>  DNA
<213>  Mus musculus

<400>  123
cactttcatt ttcttcctca ggtggggctt ga                                     32


<210>  124
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA5-4

<400>  124
tcctgagagg tcattcggca tggggaagtc gg                                     32


<210>  125
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  125
tcctgagagg tcattcggtc atggggaagt cgg                                    33


<210>  126
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence MDA5, clone gRNA4-16

<400>  126
catgtgcctg aatccctgcc catgttgctg tt                                     32


<210>  127
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  127
catggtgcct gaatccctgc ccatgttgct gtt                                    33


<210>  128
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence MDA5, clone gRNA4-16

<400>  128
catgggcctg aatccctgcc catgttgctg tt                                     32


<210>  129
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  129
catggtgcct gaatccctgc ccatgttgct gtt                                    33


<210>  130
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1/MDA5, clone gRNA4-19

<400>  130
catgtgcctg aatccctgcc catgttgctg tt                                     32


<210>  131
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  131
catggtgcct gaatccctgc ccatgttgct gtt                                    33


<210>  132
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1/MDA5, clone gRNA4-19

<400>  132
catggcctga atccctgccc atgttgctgt t                                      31


<210>  133
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  133
catggtgcct gaatccctgc ccatgttgct gtt                                    33


<210>  134
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence IFNAR1, clone gRNA1-10

<400>  134
acggtcaatg ggcagtgtga ccttttcag                                         29


<210>  135
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  135
acggagagtc aatgggcagt gtgacctttt cag                                    33


<210>  136
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence IFNAR1, clone gRNA1-10

<400>  136
acggaagagt caatgggcag tgtgaccttt tca                                    33


<210>  137
<211>  32
<212>  DNA
<213>  Mus musculus

<400>  137
acggagagtc aatgggcagt gtgacctttt ca                                     32


<210>  138
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1/IFNAR1, clone gRNA1-16

<400>  138
acggagtcaa tgggcagtgt gaccttttca g                                      31


<210>  139
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  139
acggagagtc aatgggcagt gtgacctttt cag                                    33


<210>  140
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence IFN-beta, clone gRNA3-14

<400>  140
gggcggactt caagatccta tggagatgac gg                                     32


<210>  141
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  141
gggcggactt caagatccct atggagatga cgg                                    33


<210>  142
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1/IFN-beta, clone gRNA3-16

<400>  142
gggcggactt caagatccta tggagatgac gg                                     32


<210>  143
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  143
gggcggactt caagatccct atggagatga cgg                                    33


<210>  144
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1/TRL3, clone gRNA6-7

<400>  144
actttcaaca aagggagtat ct                                                22


<210>  145
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  145
actttcaaca aagggagtat ttggcacagt tct                                    33


<210>  146
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA5-A29

<400>  146
aacaggctgc ttcctgagag gtcattcggc at                                     32


<210>  147
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  147
aacaggctgc ttcctgagag gtcattcggt cat                                    33


<210>  148
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA5-B30

<400>  148
aacaggctgc ttcctgagag gtcat                                             25


<210>  149
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  149
aacaggctgc ttcctgagag gtcattcggt cat                                    33


<210>  150
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA5-B37

<400>  150
aacaggctgc ttcctgagag gtcattctca t                                      31


<210>  151
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  151
aacaggctgc ttcctgagag gtcattcggt cat                                    33


<210>  152
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA3-8

<400>  152
aatattcatc ttctgagggt tggccaagct tt                                     32


<210>  153
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  153
aatattcatc ttctgagagg ttggccaagc ttt                                    33


<210>  154
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRISPR guide sequence LSD1, clone gRNA3-8

<400>  154
aatattcatc ttctggccaa gcttt                                             25


<210>  155
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  155
aatattcatc ttctgagagg ttggccaagc ttt                                    33


<210>  156
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  156

Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Thr Lys 
1               5                   10                  15      


<210>  157
<211>  16
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  METHYLATION

<400>  157

Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Thr Lys 
1               5                   10                  15      


