                         SEQUENCE LISTING

<110>  BASF SE
       Dubald, Manuel
 
<120>  IMPROVEMENT OF HERBICIDE TOLERANCE TO HPPD INHIBITORS BY 
       DOWN-REGULATION OF PUTATIVE 4-HYDROXYPHENYLPYRUVATE REDUCTASES IN
        SOYBEAN

<130>  APA16-6013WO

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  358
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  1

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Gly 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  2
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - PfG336W

<400>  2

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  3
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - PfHPPDEvo37

<400>  3

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Trp Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  4
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0234E6

<400>  4

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  5
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C024H11

<400>  5

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Leu Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  6
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - PfHPPDEvo33

<400>  6

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  7
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - PfHPPDEvo36

<400>  7

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Thr Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  8
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - PfHPPDEvo40

<400>  8

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Lys Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  9
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - CO210d10

<400>  9

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Thr Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  10
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - CO212f3

<400>  10

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Gly Trp 
                325                 330                 335     


Asn Phe Lys Val Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  11
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C644

<400>  11

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ile Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  12
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C645

<400>  12

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ile Gly 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  13
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - c0218A5

<400>  13

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Ala Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  14
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0216C6

<400>  14

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Thr Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  15
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - c0213H10

<400>  15

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly His Trp 
                325                 330                 335     


Asn Phe Thr Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  16
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - PfHPPDEvo41

<400>  16

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Ala Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  17
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0228G9

<400>  17

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Ile Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  18
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0232D2

<400>  18

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Trp Ser Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  19
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0234A4

<400>  19

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ala Trp 
                325                 330                 335     


Asn Phe Ser Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  20
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0235F6

<400>  20

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ala Ser 
                325                 330                 335     


Asn Phe Ser Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  21
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0235E2

<400>  21

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Ser Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  22
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0236H7

<400>  22

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Trp 
                325                 330                 335     


Asn Phe Lys Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  23
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0236F8

<400>  23

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ala Ser 
                325                 330                 335     


Asn Phe Thr Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  24
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0240D2

<400>  24

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ala Trp 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  25
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0240D12

<400>  25

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  26
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0242D4

<400>  26

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  27
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0244A2

<400>  27

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  28
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0244F5

<400>  28

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Thr Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  29
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0247B6

<400>  29

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Gln Ser 
                325                 330                 335     


Asn Phe Lys Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  30
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0247H7

<400>  30

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Trp Ser Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  31
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0252F11

<400>  31

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Thr Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  32
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0255B12

<400>  32

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Trp Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  33
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0255C1

<400>  33

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  34
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0255C3

<400>  34

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg Gly 
            340                 345                 350         


Val Leu Thr Ala Asp 
        355         


<210>  35
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0255E6

<400>  35

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Ser Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  36
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0255E10

<400>  36

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Thr Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  37
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0256B1

<400>  37

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  38
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0256G11

<400>  38

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Ser Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  39
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0256H4

<400>  39

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Ser Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  40
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0257C5

<400>  40

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  41
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0260E11

<400>  41

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  42
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0260C6

<400>  42

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Ser Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  43
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0262C4

<400>  43

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Trp 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  44
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0262F11

<400>  44

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Ser Ser 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  45
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0263B7

<400>  45

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Cys Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Thr Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  46
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0263G12

<400>  46

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Gln Trp 
                325                 330                 335     


Asn Phe Ser Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  47
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0261H2

<400>  47

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ala Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Ser Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  48
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0264G5

<400>  48

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Gln Ser 
                325                 330                 335     


Asn Phe Thr Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  49
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0264G7

<400>  49

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ser Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Lys Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  50
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - C0266A11

<400>  50

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Glu Ile Asn Leu Ile Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Ser Ile Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Asp Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Tyr 
    130                 135                 140                 


Leu Glu Gly Val Glu Arg Asn Pro Val Gly Ala Gly Leu Lys Val Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Val Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Gly Ser Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Ser Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Ala Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asp His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ala Arg Gly Ile Leu Leu Asp Gly Ser Ser Val Glu Gly Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Thr Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Thr Ala Asp 
        355             


<210>  51
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Axmi305H-Evo40

<400>  51

Met Asn Ala Val Ala Lys Ile Glu Gln His Asn Pro Ile Gly Thr Asp 
1               5                   10                  15      


Gly Phe Glu Phe Val Glu Phe Thr Ala Pro Asp Ala Lys Gly Ile Glu 
            20                  25                  30          


Gln Leu Arg Gln Leu Phe Asn Met Met Gly Phe Thr Glu Thr Ala Lys 
        35                  40                  45              


His Arg Ser Lys Glu Val Phe Leu Phe Gln Gln Asn Asp Ile Asn Ile 
    50                  55                  60                  


Val Leu Asn Gly Ser Pro Thr Gly His Val His Glu Phe Ala Leu Lys 
65                  70                  75                  80  


His Gly Pro Ser Ala Cys Ala Met Ala Phe Arg Val Lys Asn Ala Ser 
                85                  90                  95      


Gln Ala Ala Ala Tyr Ala Glu Ser Gln Gly Ala Lys Leu Val Gly Ser 
            100                 105                 110         


His Ala Asn Phe Gly Glu Leu Asn Ile Pro Ser Leu Glu Gly Ile Gly 
        115                 120                 125             


Gly Ser Leu Leu Tyr Leu Val Asp Arg Tyr Gly Asp Arg Ser Ile Tyr 
    130                 135                 140                 


Asp Val Asp Phe Glu Phe Ile Glu Gly Arg Ser Ala Asn Asp Asn Ser 
145                 150                 155                 160 


Val Gly Leu Thr Tyr Ile Asp His Leu Thr His Asn Val Lys Arg Gly 
                165                 170                 175     


Gln Met Asp Val Trp Ser Gly Phe Tyr Glu Arg Ile Ala Asn Phe Arg 
            180                 185                 190         


Glu Ile Arg Tyr Phe Asp Ile Glu Gly Lys Leu Thr Gly Leu Phe Ser 
        195                 200                 205             


Arg Ala Met Thr Ala Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu 
    210                 215                 220                 


Ser Ala Asp Asp Thr Ser Gln Ile Glu Glu Phe Ile Arg Glu Tyr His 
225                 230                 235                 240 


Gly Glu Gly Ile Gln His Ile Ala Leu Thr Thr Asp Asp Ile Tyr Ala 
                245                 250                 255     


Thr Val Arg Lys Leu Arg Asp Asn Gly Val Lys Phe Met Ser Thr Pro 
            260                 265                 270         


Asp Thr Tyr Tyr Glu Lys Val Asp Thr Arg Val Ala Gly His Gly Glu 
        275                 280                 285             


Pro Leu Glu Gln Leu Arg Glu Leu Asn Leu Leu Ile Asp Gly Ala Pro 
    290                 295                 300                 


Gly Asp Asp Gly Ile Leu Leu Gln Ile Phe Thr Asp Thr Val Ile Gly 
305                 310                 315                 320 


Pro Ile Phe Phe Glu Ile Ile Gln Arg Lys Gly Asn Gln Gly Phe Gly 
                325                 330                 335     


Pro Ser Asn Phe Lys Glu Leu Phe Glu Ser Ile Glu Glu Asp Gln Ile 
            340                 345                 350         


Arg Arg Gly Val Ile 
        355         


<210>  52
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Axmi305H-Evo41

<400>  52

Met Asn Ala Val Ala Lys Ile Glu Gln His Asn Pro Ile Gly Thr Asp 
1               5                   10                  15      


Gly Phe Glu Phe Val Glu Phe Thr Ala Pro Asp Ala Lys Gly Ile Glu 
            20                  25                  30          


Gln Leu Arg Gln Leu Phe Asn Met Met Gly Phe Thr Glu Thr Ala Lys 
        35                  40                  45              


His Arg Ser Lys Glu Val Phe Leu Phe Gln Gln Asn Asp Ile Asn Ile 
    50                  55                  60                  


Val Leu Asn Gly Ser Pro Thr Gly His Val His Glu Phe Ala Leu Lys 
65                  70                  75                  80  


His Gly Pro Ser Ala Cys Ala Met Ala Phe Arg Val Lys Asn Ala Ser 
                85                  90                  95      


Gln Ala Ala Ala Tyr Ala Glu Ser Gln Gly Ala Lys Leu Val Gly Ser 
            100                 105                 110         


His Ala Asn Phe Gly Glu Leu Asn Ile Pro Ser Leu Glu Gly Ile Gly 
        115                 120                 125             


Gly Ser Leu Leu Tyr Leu Val Asp Arg Tyr Gly Asp Arg Ser Ile Tyr 
    130                 135                 140                 


Asp Val Asp Phe Glu Phe Ile Glu Gly Arg Ser Ala Asn Asp Asn Ser 
145                 150                 155                 160 


Val Gly Leu Thr Tyr Ile Asp His Leu Thr His Asn Val Lys Arg Gly 
                165                 170                 175     


Gln Met Asp Val Trp Ser Gly Phe Tyr Glu Arg Ile Ala Asn Phe Arg 
            180                 185                 190         


Glu Ile Arg Tyr Phe Asp Ile Glu Gly Lys Leu Thr Gly Leu Phe Ser 
        195                 200                 205             


Arg Ala Met Thr Ala Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu 
    210                 215                 220                 


Ser Ala Asp Asp Thr Ser Gln Ile Glu Glu Phe Ile Arg Glu Tyr His 
225                 230                 235                 240 


Gly Glu Gly Ile Gln His Ile Ala Leu Thr Thr Asp Asp Ile Tyr Ala 
                245                 250                 255     


Thr Val Arg Lys Leu Arg Asp Asn Gly Val Lys Phe Met Ser Thr Pro 
            260                 265                 270         


Asp Thr Tyr Tyr Glu Lys Val Asp Thr Arg Val Ala Gly His Gly Glu 
        275                 280                 285             


Pro Leu Glu Gln Leu Arg Glu Leu Asn Leu Leu Ile Asp Gly Ala Pro 
    290                 295                 300                 


Gly Asp Asp Gly Ile Leu Leu Gln Ile Phe Thr Asp Thr Val Ile Gly 
305                 310                 315                 320 


Pro Ile Phe Phe Glu Ile Ile Gln Arg Lys Gly Asn Gln Gly Phe Gly 
                325                 330                 335     


Pro Trp Asn Phe Ala Gln Leu Phe Glu Ser Ile Glu Glu Asp Gln Ile 
            340                 345                 350         


Arg Arg Gly Val Ile 
        355         


<210>  53
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Axmi305H-Evo40

<400>  53

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Ala Ile Asn Leu Ile Leu Asn Asn Glu Pro His 
    50                  55                  60                  


Ser Val Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Glu Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Phe 
    130                 135                 140                 


Leu Glu Gly Val Asp Arg Asn Pro Val Gly Ala Gly Leu Lys Ile Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Ala Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ile Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Thr Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Gln Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asn His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ser Arg Gly Ile Leu Leu Asp Gly Ala Ser Asp Lys Glu Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Ser 
                325                 330                 335     


Asn Phe Lys Glu Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Ala Thr Glu 
        355             


<210>  54
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Axmi305H-Evo41

<400>  54

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Ala Ile Asn Leu Ile Leu Asn Asn Glu Pro His 
    50                  55                  60                  


Ser Val Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Glu Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Phe 
    130                 135                 140                 


Leu Glu Gly Val Asp Arg Asn Pro Val Gly Ala Gly Leu Lys Ile Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Ala Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ile Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Thr Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Gln Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asn His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ser Arg Gly Ile Leu Leu Asp Gly Ala Ser Asp Lys Glu Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Ala Gln Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Ala Thr Glu 
        355             


<210>  55
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Axmi305H-Evo40

<400>  55

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Ser 
            340                 345                 350         


Asn Phe Lys Glu Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  56
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Axmi305H-Evo41

<400>  56

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Trp 
            340                 345                 350         


Asn Phe Ala Gln Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  57
<211>  357
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  57

Met Asn Ala Val Ala Lys Ile Glu Gln His Asn Pro Ile Gly Thr Asp 
1               5                   10                  15      


Gly Phe Glu Phe Val Glu Phe Thr Ala Pro Asp Ala Lys Gly Ile Glu 
            20                  25                  30          


Gln Leu Arg Gln Leu Phe Asn Met Met Gly Phe Thr Glu Thr Ala Lys 
        35                  40                  45              


His Arg Ser Lys Glu Val Phe Leu Phe Gln Gln Asn Asp Ile Asn Ile 
    50                  55                  60                  


Val Leu Asn Gly Ser Pro Thr Gly His Val His Glu Phe Ala Leu Lys 
65                  70                  75                  80  


His Gly Pro Ser Ala Cys Ala Met Ala Phe Arg Val Lys Asn Ala Ser 
                85                  90                  95      


Gln Ala Ala Ala Tyr Ala Glu Ser Gln Gly Ala Lys Leu Val Gly Ser 
            100                 105                 110         


His Ala Asn Phe Gly Glu Leu Asn Ile Pro Ser Leu Glu Gly Ile Gly 
        115                 120                 125             


Gly Ser Leu Leu Tyr Leu Val Asp Arg Tyr Gly Asp Arg Ser Ile Tyr 
    130                 135                 140                 


Asp Val Asp Phe Glu Phe Ile Glu Gly Arg Ser Ala Asn Asp Asn Ser 
145                 150                 155                 160 


Val Gly Leu Thr Tyr Ile Asp His Leu Thr His Asn Val Lys Arg Gly 
                165                 170                 175     


Gln Met Asp Val Trp Ser Gly Phe Tyr Glu Arg Ile Ala Asn Phe Arg 
            180                 185                 190         


Glu Ile Arg Tyr Phe Asp Ile Glu Gly Lys Leu Thr Gly Leu Phe Ser 
        195                 200                 205             


Arg Ala Met Thr Ala Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu 
    210                 215                 220                 


Ser Ala Asp Asp Thr Ser Gln Ile Glu Glu Phe Ile Arg Glu Tyr His 
225                 230                 235                 240 


Gly Glu Gly Ile Gln His Ile Ala Leu Thr Thr Asp Asp Ile Tyr Ala 
                245                 250                 255     


Thr Val Arg Lys Leu Arg Asp Asn Gly Val Lys Phe Met Ser Thr Pro 
            260                 265                 270         


Asp Thr Tyr Tyr Glu Lys Val Asp Thr Arg Val Ala Gly His Gly Glu 
        275                 280                 285             


Pro Leu Glu Gln Leu Arg Glu Leu Asn Leu Leu Ile Asp Gly Ala Pro 
    290                 295                 300                 


Gly Asp Asp Gly Ile Leu Leu Gln Ile Phe Thr Asp Thr Val Ile Gly 
305                 310                 315                 320 


Pro Ile Phe Phe Glu Ile Ile Gln Arg Lys Gly Asn Gln Gly Phe Gly 
                325                 330                 335     


Glu Gly Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Glu Asp Gln Ile 
            340                 345                 350         


Arg Arg Gly Val Ile 
        355         


<210>  58
<211>  358
<212>  PRT
<213>  Pseudomonas agarici

<400>  58

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Ala Ile Asn Leu Ile Leu Asn Asn Glu Pro His 
    50                  55                  60                  


Ser Val Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Glu Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Phe 
    130                 135                 140                 


Leu Glu Gly Val Asp Arg Asn Pro Val Gly Ala Gly Leu Lys Ile Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Ala Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ile Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Thr Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Gln Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asn His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ser Arg Gly Ile Leu Leu Asp Gly Ala Ser Asp Lys Glu Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Glu Gly 
                325                 330                 335     


Asn Phe Lys Ala Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Ala Thr Glu 
        355             


<210>  59
<211>  373
<212>  PRT
<213>  Comamonas testosteroni

<400>  59

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Glu Gly 
            340                 345                 350         


Asn Phe Lys Ala Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  60
<211>  1071
<212>  DNA
<213>  Pseudomonas aeruginosa

<400>  60
atgaacgccg tggccaagat cgaacagcac aatcccatcg gtaccgacgg attcgaattc       60

gtcgagttca ccgcccccga cgccaagggc atcgagcagc tgcgccagct gttcaacatg      120

atgggcttca ccgaaaccgc caagcatcgt tccaaggaag tcttcctgtt ccagcagaac      180

gatatcaaca tcgtgctcaa cggcagccca accgggcatg tccatgaatt cgccctcaag      240

cacggcccga gcgcctgcgc catggccttc cgggtgaaga acgcttccca ggccgccgcc      300

tacgccgaat cccagggcgc caagctggtg ggcagccacg ccaacttcgg cgagctgaac      360

atcccttccc tggaaggcat cggcggttcg ctgctgtatc ttgtcgaccg ctacggcgac      420

cgcagcatct atgacgtcga cttcgagttc atcgaaggcc gcagcgccaa cgacaactcg      480

gtcggcctga cctacatcga ccacctcacc cacaacgtca agcgcggcca gatggacgtc      540

tggtccggtt tctacgagcg catcgccaac ttccgcgaga ttcgctactt cgacatcgaa      600

ggcaagctca ccggcctgtt ctcccgcgcc atgaccgcac cttgcgggaa gatccgcatc      660

ccgatcaacg agtcggccga cgatacctcg cagatcgagg aattcatccg cgaataccat      720

ggcgaaggca tccagcacat cgccctgacc accgacgaca tctatgccac cgtgcgcaag      780

ctgcgcgaca acggcgtgaa gttcatgtcg accccggaca cctactacga gaaggtcgac      840

acccgcgtcg ccgggcatgg cgagccgctc gagcaactgc gcgaactgaa cctgctgatc      900

gacggcgccc cgggcgacga cggcatcctg ctgcagatct tcaccgacac ggtgatcggc      960

ccgatcttct tcgagatcat ccagcgcaag ggcaaccagg gcttcggcga gggcaatttc     1020

aaggccctgt tcgagtccat cgaggaagac cagattcgcc gcggcgtgat c              1071


<210>  61
<211>  1074
<212>  DNA
<213>  Pseudomonas agarici

<400>  61
atggcagatt tatacgaaaa cccaatgggc ctgatgggct tcgagttcat cgagttcgca       60

tcgccgactc ctggcaccct ggagccgatc ttcgagatca tgggcttcac caaggtcgcg      120

acccaccgtt ccaagaacgt gcacctgtat cgccagggcg cgatcaacct gatcctcaac      180

aacgaacccc acagcgttgc ttcgtacttc gcggctgaac acggcccgtc cgtttgcggc      240

atggcgttcc gggtcaagga ttcgcagaag gcctacaacc gcgcactgga actcggcgcc      300

cagccgatcc acatcgaaac aggcccgatg gagctgaacc tgccggcgat caaaggcatt      360

ggcggcgcgc cgctgtacct gatcgaccgt ttcggcgaag gcagctcgat ctatgacatc      420

gacttcgtgt tcctcgaagg cgttgaccgc aacccggtcg gtgccggcct gaagatcatc      480

gaccacctga cccacaacgt gtatcgcggc cgcatggcct actgggccaa cttctacgag      540

aagctgttca acttccgcga gatccgctac ttcgacatca aaggcgaata caccggcctg      600

acctcgaaag cgatgaccgc accggacggc atgatccgca tcccgctcaa cgaagaatcg      660

tcgaagggtg ccgggcagat cgaagagttc ctgatgcagt tcaacggcga aggcatccag      720

cacgtggcgt tcctcaccga cgacctggtc aagacctggg atcagttgaa gaagatcggc      780

atgcgtttca tgaccgcgcc gccggacacc tactacgaaa tgctcgaagg ccgcctgccg      840

aaccacggcg agccggtgga tcaactgcaa tcgcgcggca tcctgctcga cggtgcgtcg      900

gataaagaag acaagcgtct gctgctgcag atcttctcgg aaaccctgat gggcccggtg      960

ttcttcgaat tcatccagcg taaaggcgat gatggtttcg gagaaggcaa cttcaaggct     1020

ctgttcgaat cgatcgagcg tgaccaggtg cgtcgtggcg tgctcgctac cgag           1074


<210>  62
<211>  1122
<212>  DNA
<213>  Comamonas testosteroni

<400>  62
atgaacgccc cgttgaccca aagcaatgcc agccagttcc agacctggga caaccccatg       60

ggcacggacg gcttcgagtt cgtcgaatac gcggcccccg atcccgtggc catgggtcag      120

ctgttcgagc gcatgggctt tcaggccatt gccaagcacc gccgcaagaa cgtgaccctg      180

tatcgccagg gcgagatcaa cttcatcatc aatgccgaac ccgacagctt tgcccagcgt      240

ttcgcgcgtc tgcacggccc cagcgtctgc gccatcgcca tccgcgtcaa cgacgccaag      300

tacgcctatg agcgcgccac ctcgctgggt gcctggggct atgcccagca ggccgccccc      360

ggcgaactga gcattcccgc catcaagggc attggcgact ccctgatcta tttcatcgac      420

aaatggcgcg gcaagaatgg cgccaaggac ggtgatctcg gcaatatcag cttcttcgac      480

gtggacttcg agcctctgcc cggtgccgat ctgcatcccg agggcctggg cctgacctat      540

atcgaccacc tgaccaacaa cgtctaccgc ggccgcatgg ccgagctggc cgagttctac      600

gagcgcatct tcaacttccg cgagatccgc tacttcgaca tcgaaggcca ggccacaggc      660

gtcaagagca aggccatgac cagcccctgc ggcaagatcc gcattcccat caacgaggaa      720

ggcaacgaca aggccggcca gattcaggag tatctggaca tgtaccgcgg cgaaggcata      780

cagcacatcg cgctgggatc gaccaatctc tacgacaccg tggacggtct gcagatgaac      840

ggcatcaagc tgctgaacac cagcgagacc tattacgagc tgctgcccaa gcgcatcccg      900

gacctgcagg aacccattcc cgagctgctg gcgcgcaaca tccttgtgga cggccagccc      960

ggcgagctgc tgctgcagat cttcagcgaa aaccagctgg gtcccatctt cttcgagttc     1020

atccagcgca agggcaatag cggctttggc gagggcaatt tcaaggcctt gttcgagacc     1080

atggaactcg accagatgcg ccgcggcgtg ctcaagacct ga                        1122


<210>  63
<211>  440
<212>  PRT
<213>  Avena sativa

<400>  63

Met Pro Pro Thr Pro Ala Thr Ala Thr Gly Ala Ala Ala Ala Ala Val 
1               5                   10                  15      


Thr Pro Glu His Ala Ala Arg Ser Phe Pro Arg Val Val Arg Val Asn 
            20                  25                  30          


Pro Arg Ser Asp Arg Phe Pro Val Leu Ser Phe His His Val Glu Leu 
        35                  40                  45              


Trp Cys Ala Asp Ala Ala Ser Ala Ala Gly Arg Phe Ser Phe Ala Leu 
    50                  55                  60                  


Gly Ala Pro Leu Ala Ala Arg Ser Asp Leu Ser Thr Gly Asn Ser Ala 
65                  70                  75                  80  


His Ala Ser Leu Leu Leu Arg Ser Gly Ala Leu Ala Phe Leu Phe Thr 
                85                  90                  95      


Ala Pro Tyr Ala Pro Pro Pro Gln Glu Ala Ala Thr Ala Ala Ala Thr 
            100                 105                 110         


Ala Ser Ile Pro Ser Phe Ser Ala Asp Ala Ala Arg Thr Phe Ala Ala 
        115                 120                 125             


Ala His Gly Leu Ala Val Arg Ser Val Gly Val Arg Val Ala Asp Ala 
    130                 135                 140                 


Ala Glu Ala Phe Arg Val Ser Val Ala Gly Gly Ala Arg Pro Ala Phe 
145                 150                 155                 160 


Ala Pro Ala Asp Leu Gly His Gly Phe Gly Leu Ala Glu Val Glu Leu 
                165                 170                 175     


Tyr Gly Asp Val Val Leu Arg Phe Val Ser Tyr Pro Asp Glu Thr Asp 
            180                 185                 190         


Leu Pro Phe Leu Pro Gly Phe Glu Arg Val Ser Ser Pro Gly Ala Val 
        195                 200                 205             


Asp Tyr Gly Leu Thr Arg Phe Asp His Val Val Gly Asn Val Pro Glu 
    210                 215                 220                 


Met Ala Pro Val Ile Asp Tyr Met Lys Gly Phe Leu Gly Phe His Glu 
225                 230                 235                 240 


Phe Ala Glu Phe Thr Ala Glu Asp Val Gly Thr Thr Glu Ser Gly Leu 
                245                 250                 255     


Asn Ser Val Val Leu Ala Asn Asn Ser Glu Ala Val Leu Leu Pro Leu 
            260                 265                 270         


Asn Glu Pro Val His Gly Thr Lys Arg Arg Ser Gln Ile Gln Thr Tyr 
        275                 280                 285             


Leu Glu Tyr His Gly Gly Pro Gly Val Gln His Ile Ala Leu Ala Ser 
    290                 295                 300                 


Asn Asp Val Leu Arg Thr Leu Arg Glu Met Arg Ala Arg Thr Pro Met 
305                 310                 315                 320 


Gly Gly Phe Glu Phe Met Ala Pro Pro Gln Ala Lys Tyr Tyr Glu Gly 
                325                 330                 335     


Val Arg Arg Ile Ala Gly Asp Val Leu Ser Glu Glu Gln Ile Lys Glu 
            340                 345                 350         


Cys Gln Glu Leu Gly Val Leu Val Asp Arg Asp Asp Gln Gly Val Leu 
        355                 360                 365             


Leu Gln Ile Phe Thr Lys Pro Val Gly Asp Arg Pro Thr Phe Phe Leu 
    370                 375                 380                 


Glu Met Ile Gln Arg Ile Gly Cys Met Glu Lys Asp Glu Val Gly Gln 
385                 390                 395                 400 


Glu Tyr Gln Lys Gly Gly Cys Gly Gly Phe Gly Lys Gly Asn Phe Ser 
                405                 410                 415     


Glu Leu Phe Lys Ser Ile Glu Asp Tyr Glu Lys Ser Leu Glu Val Lys 
            420                 425                 430         


Gln Ser Val Val Ala Gln Lys Ser 
        435                 440 


<210>  64
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPPD mutant - Avena sativum deletion mutant

<400>  64

Met Pro Pro Thr Pro Ala Thr Ala Thr Gly Ala Ala Ala Ala Ala Val 
1               5                   10                  15      


Thr Pro Glu His Ala Ala Arg Ser Phe Pro Arg Val Val Arg Val Asn 
            20                  25                  30          


Pro Arg Ser Asp Arg Phe Pro Val Leu Ser Phe His His Val Glu Leu 
        35                  40                  45              


Trp Cys Ala Asp Ala Ala Ser Ala Ala Gly Arg Phe Ser Phe Ala Leu 
    50                  55                  60                  


Gly Ala Pro Leu Ala Ala Arg Ser Asp Leu Ser Thr Gly Asn Ser Ala 
65                  70                  75                  80  


His Ala Ser Leu Leu Leu Arg Ser Gly Ala Leu Ala Phe Leu Phe Thr 
                85                  90                  95      


Ala Pro Tyr Ala Pro Pro Pro Gln Glu Ala Ala Thr Ala Ala Thr Ala 
            100                 105                 110         


Ser Ile Pro Ser Phe Ser Ala Asp Ala Ala Arg Thr Phe Ala Ala Ala 
        115                 120                 125             


His Gly Leu Ala Val Arg Ser Val Gly Val Arg Val Ala Asp Ala Ala 
    130                 135                 140                 


Glu Ala Phe Arg Val Ser Val Ala Gly Gly Ala Arg Pro Ala Phe Ala 
145                 150                 155                 160 


Pro Ala Asp Leu Gly His Gly Phe Gly Leu Ala Glu Val Glu Leu Tyr 
                165                 170                 175     


Gly Asp Val Val Leu Arg Phe Val Ser Tyr Pro Asp Glu Thr Asp Leu 
            180                 185                 190         


Pro Phe Leu Pro Gly Phe Glu Arg Val Ser Ser Pro Gly Ala Val Asp 
        195                 200                 205             


Tyr Gly Leu Thr Arg Phe Asp His Val Val Gly Asn Val Pro Glu Met 
    210                 215                 220                 


Ala Pro Val Ile Asp Tyr Met Lys Gly Phe Leu Gly Phe His Glu Phe 
225                 230                 235                 240 


Ala Glu Phe Thr Ala Glu Asp Val Gly Thr Thr Glu Ser Gly Leu Asn 
                245                 250                 255     


Ser Val Val Leu Ala Asn Asn Ser Glu Ala Val Leu Leu Pro Leu Asn 
            260                 265                 270         


Glu Pro Val His Gly Thr Lys Arg Arg Ser Gln Ile Gln Thr Tyr Leu 
        275                 280                 285             


Glu Tyr His Gly Gly Pro Gly Val Gln His Ile Ala Leu Ala Ser Asn 
    290                 295                 300                 


Asp Val Leu Arg Thr Leu Arg Glu Met Arg Ala Arg Thr Pro Met Gly 
305                 310                 315                 320 


Gly Phe Glu Phe Met Ala Pro Pro Gln Ala Lys Tyr Tyr Glu Gly Val 
                325                 330                 335     


Arg Arg Ile Ala Gly Asp Val Leu Ser Glu Glu Gln Ile Lys Glu Cys 
            340                 345                 350         


Gln Glu Leu Gly Val Leu Val Asp Arg Asp Asp Gln Gly Val Leu Leu 
        355                 360                 365             


Gln Ile Phe Thr Lys Pro Val Gly Asp Arg Pro Thr Phe Phe Leu Glu 
    370                 375                 380                 


Met Ile Gln Arg Ile Gly Cys Met Glu Lys Asp Glu Val Gly Gln Glu 
385                 390                 395                 400 


Tyr Gln Lys Gly Gly Cys Gly Gly Phe Gly Lys Gly Asn Phe Ser Glu 
                405                 410                 415     


Leu Phe Lys Ser Ile Glu Asp Tyr Glu Lys Ser Leu Glu Val Lys Gln 
            420                 425                 430         


Ser Val Val Ala Gln Lys Ser 
        435                 


<210>  65
<211>  444
<212>  PRT
<213>  Zea mays

<400>  65

Met Gly Pro Thr Pro Thr Ala Ala Ala Ala Gly Ala Ala Val Ala Ala 
1               5                   10                  15      


Ala Ser Ala Ala Glu Gln Ala Ala Phe Arg Leu Val Gly His Arg Asn 
            20                  25                  30          


Phe Val Arg Phe Asn Pro Arg Ser Asp Arg Phe His Thr Leu Ala Phe 
        35                  40                  45              


His His Val Glu Leu Trp Cys Ala Asp Ala Ala Ser Ala Ala Gly Arg 
    50                  55                  60                  


Phe Ser Phe Gly Leu Gly Ala Pro Leu Ala Ala Arg Ser Asp Leu Ser 
65                  70                  75                  80  


Thr Gly Asn Ser Ala His Ala Ser Leu Leu Leu Arg Ser Gly Ser Leu 
                85                  90                  95      


Ser Phe Leu Phe Thr Ala Pro Tyr Ala His Gly Ala Asp Ala Ala Thr 
            100                 105                 110         


Ala Ala Leu Pro Ser Phe Ser Ala Ala Ala Ala Arg Arg Phe Ala Ala 
        115                 120                 125             


Asp His Gly Leu Ala Val Arg Ala Val Ala Leu Arg Val Ala Asp Ala 
    130                 135                 140                 


Glu Asp Ala Phe Arg Ala Ser Val Ala Ala Gly Ala Arg Pro Ala Phe 
145                 150                 155                 160 


Gly Pro Val Asp Leu Gly Arg Gly Phe Arg Leu Ala Glu Val Glu Leu 
                165                 170                 175     


Tyr Gly Asp Val Val Leu Arg Tyr Val Ser Tyr Pro Asp Gly Ala Ala 
            180                 185                 190         


Gly Glu Pro Phe Leu Pro Gly Phe Glu Gly Val Ala Ser Pro Gly Ala 
        195                 200                 205             


Ala Asp Tyr Gly Leu Ser Arg Phe Asp His Ile Val Gly Asn Val Pro 
    210                 215                 220                 


Glu Leu Ala Pro Ala Ala Ala Tyr Phe Ala Gly Phe Thr Gly Phe His 
225                 230                 235                 240 


Glu Phe Ala Glu Phe Thr Thr Glu Asp Val Gly Thr Ala Glu Ser Gly 
                245                 250                 255     


Leu Asn Ser Met Val Leu Ala Asn Asn Ser Glu Asn Val Leu Leu Pro 
            260                 265                 270         


Leu Asn Glu Pro Val His Gly Thr Lys Arg Arg Ser Gln Ile Gln Thr 
        275                 280                 285             


Phe Leu Asp His His Gly Gly Pro Gly Val Gln His Met Ala Leu Ala 
    290                 295                 300                 


Ser Asp Asp Val Leu Arg Thr Leu Arg Glu Met Gln Ala Arg Ser Ala 
305                 310                 315                 320 


Met Gly Gly Phe Glu Phe Met Ala Pro Pro Thr Ser Asp Tyr Tyr Asp 
                325                 330                 335     


Gly Val Arg Arg Arg Ala Gly Asp Val Leu Thr Glu Ala Gln Ile Lys 
            340                 345                 350         


Glu Cys Gln Glu Leu Gly Val Leu Val Asp Arg Asp Asp Gln Gly Val 
        355                 360                 365             


Leu Leu Gln Ile Phe Thr Lys Pro Val Gly Asp Arg Pro Thr Leu Phe 
    370                 375                 380                 


Leu Glu Ile Ile Gln Arg Ile Gly Cys Met Glu Lys Asp Glu Lys Gly 
385                 390                 395                 400 


Gln Glu Tyr Gln Lys Gly Gly Cys Gly Gly Phe Gly Lys Gly Asn Phe 
                405                 410                 415     


Ser Gln Leu Phe Lys Ser Ile Glu Asp Tyr Glu Lys Ser Leu Glu Ala 
            420                 425                 430         


Lys Gln Ala Ala Ala Ala Ala Ala Ala Gln Gly Ser 
        435                 440                 


<210>  66
<211>  445
<212>  PRT
<213>  Arabidopsis thaliana

<400>  66

Met Gly His Gln Asn Ala Ala Val Ser Glu Asn Gln Asn His Asp Asp 
1               5                   10                  15      


Gly Ala Ala Ser Ser Pro Gly Phe Lys Leu Val Gly Phe Ser Lys Phe 
            20                  25                  30          


Val Arg Lys Asn Pro Lys Ser Asp Lys Phe Lys Val Lys Arg Phe His 
        35                  40                  45              


His Ile Glu Phe Trp Cys Gly Asp Ala Thr Asn Val Ala Arg Arg Phe 
    50                  55                  60                  


Ser Trp Gly Leu Gly Met Arg Phe Ser Ala Lys Ser Asp Leu Ser Thr 
65                  70                  75                  80  


Gly Asn Met Val His Ala Ser Tyr Leu Leu Thr Ser Gly Asp Leu Arg 
                85                  90                  95      


Phe Leu Phe Thr Ala Pro Tyr Ser Pro Ser Leu Ser Ala Gly Glu Ile 
            100                 105                 110         


Lys Pro Thr Thr Thr Ala Ser Ile Pro Ser Phe Asp His Gly Ser Cys 
        115                 120                 125             


Arg Ser Phe Phe Ser Ser His Gly Leu Gly Val Arg Ala Val Ala Ile 
    130                 135                 140                 


Glu Val Glu Asp Ala Glu Ser Ala Phe Ser Ile Ser Val Ala Asn Gly 
145                 150                 155                 160 


Ala Ile Pro Ser Ser Pro Pro Ile Val Leu Asn Glu Ala Val Thr Ile 
                165                 170                 175     


Ala Glu Val Lys Leu Tyr Gly Asp Val Val Leu Arg Tyr Val Ser Tyr 
            180                 185                 190         


Lys Ala Glu Asp Thr Glu Lys Ser Glu Phe Leu Pro Gly Phe Glu Arg 
        195                 200                 205             


Val Glu Asp Ala Ser Ser Phe Pro Leu Asp Tyr Gly Ile Arg Arg Leu 
    210                 215                 220                 


Asp His Ala Val Gly Asn Val Pro Glu Leu Gly Pro Ala Leu Thr Tyr 
225                 230                 235                 240 


Val Ala Gly Phe Thr Gly Phe His Gln Phe Ala Glu Phe Thr Ala Asp 
                245                 250                 255     


Asp Val Gly Thr Ala Glu Ser Gly Leu Asn Ser Ala Val Leu Ala Ser 
            260                 265                 270         


Asn Asp Glu Met Val Leu Leu Pro Ile Asn Glu Pro Val His Gly Thr 
        275                 280                 285             


Lys Arg Lys Ser Gln Ile Gln Thr Tyr Leu Glu His Asn Glu Gly Ala 
    290                 295                 300                 


Gly Leu Gln His Leu Ala Leu Met Ser Glu Asp Ile Phe Arg Thr Leu 
305                 310                 315                 320 


Arg Glu Met Arg Lys Arg Ser Ser Ile Gly Gly Phe Asp Phe Met Pro 
                325                 330                 335     


Ser Pro Pro Pro Thr Tyr Tyr Gln Asn Leu Lys Lys Arg Val Gly Asp 
            340                 345                 350         


Val Leu Ser Asp Asp Gln Ile Lys Glu Cys Glu Glu Leu Gly Ile Leu 
        355                 360                 365             


Val Asp Arg Asp Asp Gln Gly Thr Leu Leu Gln Ile Phe Thr Lys Pro 
    370                 375                 380                 


Leu Gly Asp Arg Pro Thr Ile Phe Ile Glu Ile Ile Gln Arg Val Gly 
385                 390                 395                 400 


Cys Met Met Lys Asp Glu Glu Gly Lys Ala Tyr Gln Ser Gly Gly Cys 
                405                 410                 415     


Gly Gly Phe Gly Lys Gly Asn Phe Ser Glu Leu Phe Lys Ser Ile Glu 
            420                 425                 430         


Glu Tyr Glu Lys Thr Leu Glu Ala Lys Gln Leu Val Gly 
        435                 440                 445 


<210>  67
<211>  434
<212>  PRT
<213>  Hordeum vulgare

<400>  67

Met Pro Pro Thr Pro Thr Thr Pro Ala Ala Thr Gly Ala Ala Ala Ala 
1               5                   10                  15      


Val Thr Pro Glu His Ala Arg Pro His Arg Met Val Arg Phe Asn Pro 
            20                  25                  30          


Arg Ser Asp Arg Phe His Thr Leu Ser Phe His His Val Glu Phe Trp 
        35                  40                  45              


Cys Ala Asp Ala Ala Ser Ala Ala Gly Arg Phe Ala Phe Ala Leu Gly 
    50                  55                  60                  


Ala Pro Leu Ala Ala Arg Ser Asp Leu Ser Thr Gly Asn Ser Ala His 
65                  70                  75                  80  


Ala Ser Gln Leu Leu Arg Ser Gly Ser Leu Ala Phe Leu Phe Thr Ala 
                85                  90                  95      


Pro Tyr Ala Asn Gly Cys Asp Ala Ala Thr Ala Ser Leu Pro Ser Phe 
            100                 105                 110         


Ser Ala Asp Ala Ala Arg Arg Phe Ser Ala Asp His Gly Ile Ala Val 
        115                 120                 125             


Arg Ser Val Ala Leu Arg Val Ala Asp Ala Ala Glu Ala Phe Arg Ala 
    130                 135                 140                 


Ser Arg Arg Arg Gly Ala Arg Pro Ala Phe Ala Pro Val Asp Leu Gly 
145                 150                 155                 160 


Arg Gly Phe Ala Phe Ala Glu Val Glu Leu Tyr Gly Asp Val Val Leu 
                165                 170                 175     


Arg Phe Val Ser His Pro Asp Gly Thr Asp Val Pro Phe Leu Pro Gly 
            180                 185                 190         


Phe Glu Gly Val Thr Asn Pro Asp Ala Val Asp Tyr Gly Leu Thr Arg 
        195                 200                 205             


Phe Asp His Val Val Gly Asn Val Pro Glu Leu Ala Pro Ala Ala Ala 
    210                 215                 220                 


Tyr Ile Ala Gly Phe Thr Gly Phe His Glu Phe Ala Glu Phe Thr Ala 
225                 230                 235                 240 


Glu Asp Val Gly Thr Thr Glu Ser Gly Leu Asn Ser Val Val Leu Ala 
                245                 250                 255     


Asn Asn Ser Glu Gly Val Leu Leu Pro Leu Asn Glu Pro Val His Gly 
            260                 265                 270         


Thr Lys Arg Arg Ser Gln Ile Gln Thr Phe Leu Glu His His Gly Gly 
        275                 280                 285             


Pro Gly Val Gln His Ile Ala Val Ala Ser Ser Asp Val Leu Arg Thr 
    290                 295                 300                 


Leu Arg Lys Met Arg Ala Arg Ser Ala Met Gly Gly Phe Asp Phe Leu 
305                 310                 315                 320 


Pro Pro Pro Leu Pro Lys Tyr Tyr Glu Gly Val Arg Arg Leu Ala Gly 
                325                 330                 335     


Asp Val Leu Ser Glu Ala Gln Ile Lys Glu Cys Gln Glu Leu Gly Val 
            340                 345                 350         


Leu Val Asp Arg Asp Asp Gln Gly Val Leu Leu Gln Ile Phe Thr Lys 
        355                 360                 365             


Pro Val Gly Asp Arg Pro Thr Leu Phe Leu Glu Met Ile Gln Arg Ile 
    370                 375                 380                 


Gly Cys Met Glu Lys Asp Glu Arg Gly Glu Glu Tyr Gln Lys Gly Gly 
385                 390                 395                 400 


Cys Gly Gly Phe Gly Lys Gly Asn Phe Ser Glu Leu Phe Lys Ser Ile 
                405                 410                 415     


Glu Asp Tyr Glu Lys Ser Leu Glu Ala Lys Gln Ser Ala Ala Val Gln 
            420                 425                 430         


Gly Ser 
        


<210>  68
<211>  442
<212>  PRT
<213>  Daucus carota

<400>  68

Met Gly Lys Lys Gln Ser Glu Ala Glu Ile Leu Ser Ser Asn Ser Ser 
1               5                   10                  15      


Asn Thr Ser Pro Ala Thr Phe Lys Leu Val Gly Phe Asn Asn Phe Val 
            20                  25                  30          


Arg Ala Asn Pro Lys Ser Asp His Phe Ala Val Lys Arg Phe His His 
        35                  40                  45              


Ile Glu Phe Trp Cys Gly Asp Ala Thr Asn Thr Ser Arg Arg Phe Ser 
    50                  55                  60                  


Trp Gly Leu Gly Met Pro Leu Val Ala Lys Ser Asp Leu Ser Thr Gly 
65                  70                  75                  80  


Asn Ser Val His Ala Ser Tyr Leu Val Arg Ser Ala Asn Leu Ser Phe 
                85                  90                  95      


Val Phe Thr Ala Pro Tyr Ser Pro Ser Thr Thr Thr Ser Ser Gly Ser 
            100                 105                 110         


Ala Ala Ile Pro Ser Phe Ser Ala Ser Gly Phe His Ser Phe Ala Ala 
        115                 120                 125             


Lys His Gly Leu Ala Val Arg Ala Ile Ala Leu Glu Val Ala Asp Val 
    130                 135                 140                 


Ala Ala Ala Phe Glu Ala Ser Val Ala Arg Gly Ala Arg Pro Ala Ser 
145                 150                 155                 160 


Ala Pro Val Glu Leu Asp Asp Gln Ala Trp Leu Ala Glu Val Glu Leu 
                165                 170                 175     


Tyr Gly Asp Val Val Leu Arg Phe Val Ser Phe Gly Arg Glu Glu Gly 
            180                 185                 190         


Leu Phe Leu Pro Gly Phe Glu Ala Val Glu Gly Thr Ala Ser Phe Pro 
        195                 200                 205             


Asp Leu Asp Tyr Gly Ile Arg Arg Leu Asp His Ala Val Gly Asn Val 
    210                 215                 220                 


Thr Glu Leu Gly Pro Val Val Glu Tyr Ile Lys Gly Phe Thr Gly Phe 
225                 230                 235                 240 


His Glu Phe Ala Glu Phe Thr Ala Glu Asp Val Gly Thr Leu Glu Ser 
                245                 250                 255     


Gly Leu Asn Ser Val Val Leu Ala Asn Asn Glu Glu Met Val Leu Leu 
            260                 265                 270         


Pro Leu Asn Glu Pro Val Tyr Gly Thr Lys Arg Lys Ser Gln Ile Gln 
        275                 280                 285             


Thr Tyr Leu Glu His Asn Glu Gly Ala Gly Val Gln His Leu Ala Leu 
    290                 295                 300                 


Val Ser Glu Asp Ile Phe Arg Thr Leu Arg Glu Met Arg Lys Arg Ser 
305                 310                 315                 320 


Cys Leu Gly Gly Phe Glu Phe Met Pro Ser Pro Pro Pro Thr Tyr Tyr 
                325                 330                 335     


Lys Asn Leu Lys Asn Arg Val Gly Asp Val Leu Ser Asp Glu Gln Ile 
            340                 345                 350         


Lys Glu Cys Glu Asp Leu Gly Ile Leu Val Asp Arg Asp Asp Gln Gly 
        355                 360                 365             


Thr Leu Leu Gln Ile Phe Thr Lys Pro Val Gly Asp Arg Pro Thr Leu 
    370                 375                 380                 


Phe Ile Glu Ile Ile Gln Arg Val Gly Cys Met Leu Lys Asp Asp Ala 
385                 390                 395                 400 


Gly Gln Met Tyr Gln Lys Gly Gly Cys Gly Gly Phe Gly Lys Gly Asn 
                405                 410                 415     


Phe Ser Glu Leu Phe Lys Ser Ile Glu Glu Tyr Glu Lys Thr Leu Glu 
            420                 425                 430         


Ala Lys Gln Ile Thr Gly Ser Ala Ala Ala 
        435                 440         


<210>  69
<211>  380
<212>  PRT
<213>  Streptomyces avermitilis

<400>  69

Met Thr Gln Thr Thr His His Thr Pro Asp Thr Ala Arg Gln Ala Asp 
1               5                   10                  15      


Pro Phe Pro Val Lys Gly Met Asp Ala Val Val Phe Ala Val Gly Asn 
            20                  25                  30          


Ala Lys Gln Ala Ala His Tyr Ser Thr Ala Phe Gly Met Gln Leu Val 
        35                  40                  45              


Ala Tyr Ser Gly Pro Glu Asn Gly Ser Arg Glu Thr Ala Ser Tyr Val 
    50                  55                  60                  


Leu Thr Asn Gly Ser Ala Arg Phe Val Leu Thr Ser Val Ile Lys Pro 
65                  70                  75                  80  


Ala Thr Pro Trp Gly His Phe Leu Ala Asp His Val Ala Glu His Gly 
                85                  90                  95      


Asp Gly Val Val Asp Leu Ala Ile Glu Val Pro Asp Ala Arg Ala Ala 
            100                 105                 110         


His Ala Tyr Ala Ile Glu His Gly Ala Arg Ser Val Ala Glu Pro Tyr 
        115                 120                 125             


Glu Leu Lys Asp Glu His Gly Thr Val Val Leu Ala Ala Ile Ala Thr 
    130                 135                 140                 


Tyr Gly Lys Thr Arg His Thr Leu Val Asp Arg Thr Gly Tyr Asp Gly 
145                 150                 155                 160 


Pro Tyr Leu Pro Gly Tyr Val Ala Ala Ala Pro Ile Val Glu Pro Pro 
                165                 170                 175     


Ala His Arg Thr Phe Gln Ala Ile Asp His Cys Val Gly Asn Val Glu 
            180                 185                 190         


Leu Gly Arg Met Asn Glu Trp Val Gly Phe Tyr Asn Lys Val Met Gly 
        195                 200                 205             


Phe Thr Asn Met Lys Glu Phe Val Gly Asp Asp Ile Ala Thr Glu Tyr 
    210                 215                 220                 


Ser Ala Leu Met Ser Lys Val Val Ala Asp Gly Thr Leu Lys Val Lys 
225                 230                 235                 240 


Phe Pro Ile Asn Glu Pro Ala Leu Ala Lys Lys Lys Ser Gln Ile Asp 
                245                 250                 255     


Glu Tyr Leu Glu Phe Tyr Gly Gly Ala Gly Val Gln His Ile Ala Leu 
            260                 265                 270         


Asn Thr Gly Asp Ile Val Glu Thr Val Arg Thr Met Arg Ala Ala Gly 
        275                 280                 285             


Val Gln Phe Leu Asp Thr Pro Asp Ser Tyr Tyr Asp Thr Leu Gly Glu 
    290                 295                 300                 


Trp Val Gly Asp Thr Arg Val Pro Val Asp Thr Leu Arg Glu Leu Lys 
305                 310                 315                 320 


Ile Leu Ala Asp Arg Asp Glu Asp Gly Tyr Leu Leu Gln Ile Phe Thr 
                325                 330                 335     


Lys Pro Val Gln Asp Arg Pro Thr Val Phe Phe Glu Ile Ile Glu Arg 
            340                 345                 350         


His Gly Ser Met Gly Phe Gly Lys Gly Asn Phe Lys Ala Leu Phe Glu 
        355                 360                 365             


Ala Ile Glu Arg Glu Gln Glu Lys Arg Gly Asn Leu 
    370                 375                 380 


<210>  70
<211>  419
<212>  PRT
<213>  Mycosphaerella graminicola

<400>  70

Met Ala Pro Gly Ala Leu Leu Val Thr Ser Gln Asn Gly Arg Thr Ser 
1               5                   10                  15      


Pro Leu Tyr Asp Ser Asp Gly Tyr Val Pro Ala Pro Ala Ala Leu Val 
            20                  25                  30          


Val Gly Gly Glu Val Asn Tyr Arg Gly Tyr His His Ala Glu Trp Trp 
        35                  40                  45              


Val Gly Asn Ala Lys Gln Val Ala Gln Phe Tyr Ile Thr Arg Met Gly 
    50                  55                  60                  


Phe Glu Pro Val Ala His Lys Gly Leu Glu Thr Gly Ser Arg Phe Phe 
65                  70                  75                  80  


Ala Ser His Val Val Gln Asn Asn Gly Val Arg Phe Val Phe Thr Ser 
                85                  90                  95      


Pro Val Arg Ser Ser Ala Arg Gln Thr Leu Lys Ala Ala Pro Leu Ala 
            100                 105                 110         


Asp Gln Ala Arg Leu Asp Glu Met Tyr Asp His Leu Asp Lys His Gly 
        115                 120                 125             


Asp Gly Val Lys Asp Val Ala Phe Glu Val Asp Asp Val Leu Ala Val 
    130                 135                 140                 


Tyr Glu Asn Ala Val Ala Asn Gly Ala Glu Ser Val Ser Ser Pro His 
145                 150                 155                 160 


Thr Asp Ser Cys Asp Glu Gly Asp Val Ile Ser Ala Ala Ile Lys Thr 
                165                 170                 175     


Tyr Gly Asp Thr Thr His Thr Phe Ile Gln Arg Thr Thr Tyr Thr Gly 
            180                 185                 190         


Pro Phe Leu Pro Gly Tyr Arg Ser Cys Thr Thr Val Asp Ser Ala Asn 
        195                 200                 205             


Lys Phe Leu Pro Pro Val Asn Leu Glu Ala Ile Asp His Cys Val Gly 
    210                 215                 220                 


Asn Gln Asp Trp Asp Glu Met Ser Asp Ala Cys Asp Phe Tyr Glu Arg 
225                 230                 235                 240 


Cys Leu Gly Phe His Arg Phe Trp Ser Val Asp Asp Lys Asp Ile Cys 
                245                 250                 255     


Thr Glu Phe Ser Ala Leu Lys Ser Ile Val Met Ser Ser Pro Asn Gln 
            260                 265                 270         


Val Val Lys Met Pro Ile Asn Glu Pro Ala His Gly Lys Lys Lys Ser 
        275                 280                 285             


Gln Ile Glu Glu Tyr Val Asp Phe Tyr Asn Gly Pro Gly Val Gln His 
    290                 295                 300                 


Ile Ala Leu Arg Thr Pro Asn Ile Ile Glu Ala Val Ser Asn Leu Arg 
305                 310                 315                 320 


Ser Arg Gly Val Glu Phe Ile Ser Val Pro Asp Thr Tyr Tyr Glu Asn 
                325                 330                 335     


Met Arg Leu Arg Leu Lys Ala Ala Gly Met Lys Leu Glu Glu Ser Phe 
            340                 345                 350         


Asp Ile Ile Gln Lys Leu Asn Ile Leu Ile Asp Phe Asp Glu Gly Gly 
        355                 360                 365             


Tyr Leu Leu Gln Leu Phe Thr Lys Pro Leu Met Asp Arg Pro Thr Val 
    370                 375                 380                 


Phe Ile Glu Ile Ile Gln Arg Asn Asn Phe Asp Gly Phe Gly Ala Gly 
385                 390                 395                 400 


Asn Phe Lys Ser Leu Phe Glu Ala Ile Glu Arg Glu Gln Asp Leu Arg 
                405                 410                 415     


Gly Asn Leu 
            


<210>  71
<211>  399
<212>  PRT
<213>  Coccicoides immitis

<400>  71

Met Ala Pro Ala Ala Asp Ser Pro Thr Leu Gln Pro Ala Gln Pro Ser 
1               5                   10                  15      


Asp Leu Asn Gln Tyr Arg Gly Tyr Asp His Val His Trp Tyr Val Gly 
            20                  25                  30          


Asn Ala Lys Gln Ala Ala Thr Tyr Tyr Val Thr Arg Met Gly Phe Glu 
        35                  40                  45              


Arg Val Ala Tyr Arg Gly Leu Glu Thr Gly Ser Lys Ala Val Ala Ser 
    50                  55                  60                  


His Val Val Arg Asn Gly Asn Ile Thr Phe Ile Leu Thr Ser Pro Leu 
65                  70                  75                  80  


Arg Ser Val Glu Gln Ala Ser Arg Phe Pro Glu Asp Glu Ala Leu Leu 
                85                  90                  95      


Lys Glu Ile His Ala His Leu Glu Arg His Gly Asp Gly Val Lys Asp 
            100                 105                 110         


Val Ala Phe Glu Val Asp Cys Val Glu Ser Val Phe Ser Ala Ala Val 
        115                 120                 125             


Arg Asn Gly Ala Glu Val Val Ser Asp Val Arg Thr Val Glu Asp Glu 
    130                 135                 140                 


Asp Gly Gln Ile Lys Met Ala Thr Ile Arg Thr Tyr Gly Glu Thr Thr 
145                 150                 155                 160 


His Thr Leu Ile Glu Arg Ser Gly Tyr Arg Gly Gly Phe Met Pro Gly 
                165                 170                 175     


Tyr Arg Met Glu Ser Asn Ala Asp Ala Thr Ser Lys Phe Leu Pro Lys 
            180                 185                 190         


Val Val Leu Glu Arg Ile Asp His Cys Val Gly Asn Gln Asp Trp Asp 
        195                 200                 205             


Glu Met Glu Arg Val Cys Asp Tyr Tyr Glu Lys Ile Leu Gly Phe His 
    210                 215                 220                 


Arg Phe Trp Ser Val Asp Asp Lys Asp Ile Cys Thr Glu Phe Ser Ala 
225                 230                 235                 240 


Leu Lys Ser Ile Val Met Ala Ser Pro Asn Asp Ile Val Lys Met Pro 
                245                 250                 255     


Ile Asn Glu Pro Ala Lys Gly Lys Lys Gln Ser Gln Ile Glu Glu Tyr 
            260                 265                 270         


Val Asp Phe Tyr Asn Gly Ala Gly Val Gln His Ile Ala Leu Arg Thr 
        275                 280                 285             


Asn Asn Ile Ile Asp Ala Ile Thr Asn Leu Lys Ala Arg Gly Thr Glu 
    290                 295                 300                 


Phe Ile Lys Val Pro Glu Thr Tyr Tyr Glu Asp Met Lys Ile Arg Leu 
305                 310                 315                 320 


Lys Arg Gln Gly Leu Val Leu Asp Glu Asp Phe Glu Thr Leu Lys Ser 
                325                 330                 335     


Leu Asp Ile Leu Ile Asp Phe Asp Glu Asn Gly Tyr Leu Leu Gln Leu 
            340                 345                 350         


Phe Thr Lys His Leu Met Asp Arg Pro Thr Val Phe Ile Glu Ile Ile 
        355                 360                 365             


Gln Arg Asn Asn Phe Ser Gly Phe Gly Ala Gly Asn Phe Arg Ala Leu 
    370                 375                 380                 


Phe Glu Ala Ile Glu Arg Glu Gln Ala Leu Arg Gly Thr Leu Ile 
385                 390                 395                 


<210>  72
<211>  350
<212>  PRT
<213>  Synechococcoideae spp.

<400>  72

Met Asn Pro Ser Ile Arg Ile Val Gln Gly Ile His His Leu His Phe 
1               5                   10                  15      


Tyr Leu Trp Asp Leu Pro Arg Trp Arg Glu His Phe Cys Arg Val Trp 
            20                  25                  30          


Gly Phe Arg Val Ala Ser Asp Ala Gly Asn Thr Leu Glu Leu Glu Gln 
        35                  40                  45              


Gly Ser Leu Arg Leu Arg Leu Ser Gln Pro Ala Arg Ala Gly Asp Glu 
    50                  55                  60                  


Val Asp Arg His Leu Gln Arg His Gly Pro Gly Val Val Asp Val Ala 
65                  70                  75                  80  


Leu Ala Val Gly Glu Gln Glu Leu Pro Ala Leu Ala Glu Leu Leu Arg 
                85                  90                  95      


Gly Arg Gly Ala Gln Leu Ala Trp Ile Pro Ala Ala Ala Ala Leu Cys 
            100                 105                 110         


Leu His Thr Pro Tyr Gly Ile Arg His Ser Leu Ile Pro Gly Pro Leu 
        115                 120                 125             


Asp Ala Ala Pro Ala Glu Ala Gly Leu Phe Ser His Trp Asp His Val 
    130                 135                 140                 


Val Leu Asn Val Glu Gln Gly Ser Leu Gln Ala Ala Ala Asp Trp Tyr 
145                 150                 155                 160 


Gly Arg Val Leu Gly Trp Arg Arg Leu Tyr Arg Tyr Ser Ile Gly Thr 
                165                 170                 175     


Ala Thr Ser Gly Leu Glu Ser Val Val Val Gly Asp Pro Glu Ala Gly 
            180                 185                 190         


Ile Gln Trp Ala Ile Asn Glu Pro Thr Cys Ala Ala Ser Gln Ile Gln 
        195                 200                 205             


Glu Phe Leu His Ala His Gly Gly Pro Gly Ile Gln His Ala Ala Leu 
    210                 215                 220                 


His Ser Ser Asp Ile Val Ala Ser Leu Arg Arg Leu Arg Gln Gly Gly 
225                 230                 235                 240 


Val Asp Phe Leu Gln Val Ala Pro Gln Tyr Tyr Thr Ser Leu Glu Arg 
                245                 250                 255     


Glu Leu Gly Leu Ala Leu Arg Ser Ala Leu Gly Gln Ala Ile Ser Trp 
            260                 265                 270         


Gln Asp Leu Val Glu Gln Gln Ile Leu Leu Asp Ala Thr Leu Pro Ala 
        275                 280                 285             


Ser Asp Gly Gln Asp Arg Pro Leu Leu Leu Gln Thr Phe Thr Gln Pro 
    290                 295                 300                 


Leu Phe Gly Arg Pro Thr Phe Phe Phe Glu Val Ile Gln Arg Leu Gly 
305                 310                 315                 320 


Gly Ala Thr Gly Phe Gly Glu Ala Asn Phe Gln Ala Leu Phe Glu Ala 
                325                 330                 335     


Leu Glu Arg Gln Gln Arg Gln Arg His Gln Ala Leu Thr Pro 
            340                 345                 350 


<210>  73
<211>  368
<212>  PRT
<213>  Picrophilus torridus

<400>  73

Met Tyr Gly Lys Asn Leu Ile Ser Glu Leu Arg Glu Lys Glu Ile Phe 
1               5                   10                  15      


Lys Arg Leu His His Val Glu Phe Tyr Val Ser Ser Ala Lys Thr Trp 
            20                  25                  30          


Ser Tyr Phe Met Asn Arg Gly Leu Gly Phe Lys Thr Val Ala Tyr Ala 
        35                  40                  45              


Gly Pro Glu Thr Gly Ile Arg Asp Lys Ile Ser Tyr Val Met Ser Gln 
    50                  55                  60                  


Gly Thr Ala Arg Ile Ser Phe Thr Ser Ser Met Asn Asp Asp Ser Tyr 
65                  70                  75                  80  


Ile Ser Asn His Val Lys Lys His Gly Asp Gly Val Lys Asp Ile Ala 
                85                  90                  95      


Leu Glu Val Asp Asp Leu Asp Glu Ala Lys Ser Leu Ile Glu Lys Tyr 
            100                 105                 110         


Gly Thr Lys Val Ser Lys Ile Asn Glu Ile Lys Asp Gly Asn Gly Lys 
        115                 120                 125             


Ile Arg Thr Ala Glu Ile Lys Thr Tyr Gly Glu Thr Val His Thr Leu 
    130                 135                 140                 


Ile Glu Thr Gly Asp Tyr Asn Gly Val Phe Met Pro Gly Tyr Glu Glu 
145                 150                 155                 160 


Ser Glu Ile Asn Ser Lys Asn Thr Gly Ile Lys Lys Ile Asp His Ile 
                165                 170                 175     


Val Gly Asn Val Tyr Glu Gly Glu Met Asp Ser Trp Val Asn Phe Tyr 
            180                 185                 190         


Ile Glu Lys Leu Gly Phe Glu His Leu Ile Thr Phe Asp Asp Lys Asp 
        195                 200                 205             


Ile Arg Thr Asp Tyr Ser Ala Leu Arg Ser Lys Val Val Lys Tyr Asn 
    210                 215                 220                 


Asp Asp Ile Val Phe Pro Ile Asn Glu Pro Ala Lys Gly Leu Arg Lys 
225                 230                 235                 240 


Ser Gln Ile Glu Glu Tyr Leu Asp Tyr Tyr Arg Ser Glu Gly Val Gln 
                245                 250                 255     


His Ile Ala Leu Leu Thr Asp Asp Ile Ile Lys Thr Val Ser Met Met 
            260                 265                 270         


Glu Glu Asn Gly Ile Glu Phe Leu Lys Thr Pro Gly Ser Tyr Tyr Glu 
        275                 280                 285             


Ser Leu Ser Ser Arg Ile Gly Ser Ile Asp Glu Asp Leu Asn Glu Ile 
    290                 295                 300                 


Glu Lys His Asn Ile Leu Val Asp Arg Asp Glu Asn Gly Tyr Leu Leu 
305                 310                 315                 320 


Gln Ile Phe Thr Lys Pro Val Thr Asp Arg Pro Thr Phe Phe Phe Glu 
                325                 330                 335     


Val Ile Gln Arg Lys Gly Ala Arg Ser Phe Gly Asn Gly Asn Phe Lys 
            340                 345                 350         


Ala Leu Phe Glu Ala Ile Glu Arg Glu Gln Ala Lys Arg Gly Asn Leu 
        355                 360                 365             


<210>  74
<211>  387
<212>  PRT
<213>  Kordia algicida

<400>  74

Met Ala Ala Glu Ile Lys Asn Leu Lys Asp Leu Gln Asn Thr Glu Tyr 
1               5                   10                  15      


Gly Leu Lys Lys Leu Phe Asp Glu Ala Glu Asp Phe Leu Pro Leu Leu 
            20                  25                  30          


Gly Thr Asp Tyr Val Glu Leu Tyr Val Gly Asn Ala Lys Gln Ser Ala 
        35                  40                  45              


His Phe Tyr Lys Thr Ala Phe Gly Phe Gln Ser Glu Ala Tyr Ala Gly 
    50                  55                  60                  


Leu Glu Thr Gly Leu Thr Asp Arg Val Ser Tyr Val Leu Lys Gln Asp 
65                  70                  75                  80  


Lys Ile Arg Leu Val Leu Thr Thr Pro Leu Gly Lys Gly Gly Glu Ile 
                85                  90                  95      


Asn Glu His Ile Asp Leu His Gly Asp Gly Val Lys Val Val Ala Leu 
            100                 105                 110         


Trp Val Glu Asp Ala Thr Lys Ala Phe Glu Glu Thr Thr Lys Arg Gly 
        115                 120                 125             


Ala Lys Pro Tyr Met Glu Pro Thr Lys Glu Glu Asp Glu Asn Gly Tyr 
    130                 135                 140                 


Val Ile Arg Ser Gly Ile Tyr Thr Tyr Gly Glu Thr Val His Val Phe 
145                 150                 155                 160 


Val Glu Arg Lys Asn Tyr Asn Gly Val Phe Leu Pro Gly Tyr Gln Arg 
                165                 170                 175     


Trp Glu Ser His Tyr Asn Pro Glu Pro Val Gly Leu Lys Phe Ile Asp 
            180                 185                 190         


His Met Val Gly Asn Val Gly Trp Gly Glu Met Lys Glu Trp Cys Glu 
        195                 200                 205             


Phe Tyr Ala Lys Val Met Gly Phe Ala Gln Ile Ile Ser Phe Thr Asp 
    210                 215                 220                 


Asp Asp Ile Ser Thr Asp Phe Thr Ala Leu Met Ser Lys Val Met Ser 
225                 230                 235                 240 


Asn Gly Asn Gly Arg Ile Lys Phe Pro Ile Asn Glu Pro Ala Glu Gly 
                245                 250                 255     


Lys Lys Lys Ser Gln Ile Glu Glu Tyr Leu Asp Phe Tyr Asn Gly Ser 
            260                 265                 270         


Gly Val Gln His Ile Ala Val Ala Thr Asp Asn Ile Ile Asp Thr Val 
        275                 280                 285             


Ser Gln Met Arg Glu Arg Gly Val Glu Phe Leu Tyr Val Pro Asp Thr 
    290                 295                 300                 


Tyr Tyr Asp Asp Leu Leu Glu Arg Val Gly Asp Ile Asp Glu Asp Val 
305                 310                 315                 320 


Glu Glu Leu Lys Lys His Gly Ile Leu Ile Asp Arg Asp Glu Glu Gly 
                325                 330                 335     


Tyr Leu Leu Gln Leu Phe Thr Lys Thr Ile Val Asp Arg Pro Thr Met 
            340                 345                 350         


Phe Phe Glu Val Ile Gln Arg Lys Gly Ala Gln Ser Phe Gly Val Gly 
        355                 360                 365             


Asn Phe Lys Ala Leu Phe Glu Ala Ile Glu Arg Glu Gln Ala Ala Arg 
    370                 375                 380                 


Gly Thr Leu 
385         


<210>  75
<211>  382
<212>  PRT
<213>  Blepharisma japonicum

<400>  75

Met Thr Tyr Tyr Asp Lys Gln Glu Thr Arg Pro Asp Leu Gly Glu Phe 
1               5                   10                  15      


Tyr Gly Phe His His Val Arg Phe Tyr Val Ser Asn Ser Glu Gln Ala 
            20                  25                  30          


Ala Ser Phe Tyr Thr Ser Arg Phe Gly Phe Ser Pro Val Ala Tyr Glu 
        35                  40                  45              


Gly Leu Glu Thr Gly Asn Gln Lys Phe Cys Thr Asn Val Val Arg Ser 
    50                  55                  60                  


Asn His Val Val Ile Ala Phe Thr Ser Ala Leu Thr Pro Glu Asp Asn 
65                  70                  75                  80  


Glu Val Asn Arg His Val Gly Lys His Ser Asp Gly Val Gln Asp Ile 
                85                  90                  95      


Ala Phe Ser Val Ser Asp Ala Arg Gly Met Tyr Glu Lys Ala Ile Ala 
            100                 105                 110         


Lys Gly Cys Lys Ser Phe Arg Glu Pro Gln Val Leu Gln Asp Gln Phe 
        115                 120                 125             


Gly Ser Val Ile Ile Ala Ser Leu Gln Thr Tyr Gly Asp Thr Val His 
    130                 135                 140                 


Thr Leu Val Gln Asn Val Asp Tyr Thr Gly Pro Phe Leu Pro Gly Phe 
145                 150                 155                 160 


Arg Ala Ile Thr Lys Asp Asp Pro Leu Asn Ser Ala Phe Pro Gln Val 
                165                 170                 175     


Asn Tyr Asp Ile Ile Asp His Val Val Gly Asn Gln Pro Gly Gly Asp 
            180                 185                 190         


Met Thr Pro Thr Val Glu Trp Tyr Glu Lys Tyr Leu Glu Phe His Arg 
        195                 200                 205             


Tyr Trp Ser Ala Asp Glu Ser Val Ile His Thr Asp Tyr Ser Ala Leu 
    210                 215                 220                 


Arg Ser Val Val Val Ala Asp Trp Asp Glu Val Ile Lys Met Pro Ile 
225                 230                 235                 240 


Asn Glu Pro Ala Asp Gly Leu Arg Lys Ser Gln Ile Gln Glu Tyr Val 
                245                 250                 255     


Glu Tyr Tyr Gly Gly Ala Gly Val Gln His Ile Ala Leu Lys Val Asn 
            260                 265                 270         


Asp Ile Ile Ser Val Ile Ser Thr Leu Arg Ala Arg Gly Val Glu Phe 
        275                 280                 285             


Leu Glu Val Pro Pro Lys Tyr Tyr Asp Ser Leu Arg Lys Arg Leu Ala 
    290                 295                 300                 


His Ser Ala Val Gln Ile Glu Glu Asp Leu Lys Arg Ile Glu Asp Leu 
305                 310                 315                 320 


His Ile Leu Val Asp Phe Asp Asp Arg Gly Tyr Leu Leu Gln Ile Phe 
                325                 330                 335     


Thr Lys Pro Val Glu Asp Arg Pro Thr Leu Phe Tyr Glu Ile Ile Gln 
            340                 345                 350         


Arg His Asn Asn Asn Gly Phe Gly Ile Gly Asn Phe Lys Ala Leu Phe 
        355                 360                 365             


Glu Ser Leu Glu Gln Glu Gln Glu Arg Arg Gly Asn Leu Ile 
    370                 375                 380         


<210>  76
<211>  401
<212>  PRT
<213>  Rhodococcus sp.

<400>  76

Met Thr Ile Glu Gln Thr Leu Thr Asp Lys Glu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Asp Leu Gly Gln Leu Glu Gln Leu Val Gly Leu Val Glu Tyr Asp Gly 
            20                  25                  30          


Thr Arg Asp Pro Phe Pro Val Ser Gly Trp Asp Ala Val Val Trp Val 
        35                  40                  45              


Val Gly Asn Ala Thr Gln Thr Ala His Tyr Phe Gln Ser Ala Phe Gly 
    50                  55                  60                  


Met Thr Leu Val Ala Tyr Ser Gly Pro Thr Thr Gly Asn Arg Asp His 
65                  70                  75                  80  


His Ser Phe Val Leu Glu Ser Gly Ala Val Arg Phe Val Ile Lys Gly 
                85                  90                  95      


Ala Val Asn Pro Asp Ser Pro Leu Ile Asp His His Arg Thr His Gly 
            100                 105                 110         


Asp Gly Val Val Asp Ile Ala Leu Ala Val Pro Asp Val Asp Lys Cys 
        115                 120                 125             


Ile Ala His Ala Arg Ala Gln Gly Ala Thr Val Leu Asp Glu Pro His 
    130                 135                 140                 


Asp Val Thr Asp Asp His Gly Thr Val Arg Leu Ala Ala Ile Ala Thr 
145                 150                 155                 160 


Tyr Gly Asp Thr Arg His Thr Leu Val Asp Arg Ser His Tyr Thr Gly 
                165                 170                 175     


Pro Tyr Leu Pro Gly Tyr Thr Ala Arg Thr Ser Gly His Thr Lys Arg 
            180                 185                 190         


Asp Gly Ala Pro Lys Arg Leu Phe Gln Ala Leu Asp His Val Val Gly 
        195                 200                 205             


Asn Val Glu Leu Gly Lys Met Asp His Trp Val Asp Phe Tyr Asn Arg 
    210                 215                 220                 


Val Met Gly Phe Thr Asn Met Ala Glu Phe Val Gly Glu Asp Ile Ala 
225                 230                 235                 240 


Thr Asp Tyr Ser Ala Leu Met Ser Lys Val Val Ser Asn Gly Asn His 
                245                 250                 255     


Arg Val Lys Phe Pro Leu Asn Glu Pro Ala Leu Ala Lys Lys Arg Ser 
            260                 265                 270         


Gln Ile Asp Glu Tyr Leu Asp Phe Tyr Arg Gly Pro Gly Ala Gln His 
        275                 280                 285             


Leu Ala Leu Ala Thr Asn Asp Ile Leu Thr Ala Val Asp Gln Leu Thr 
    290                 295                 300                 


Ala Glu Gly Val Glu Phe Leu Ala Thr Pro Asp Ser Tyr Tyr Glu Asp 
305                 310                 315                 320 


Pro Glu Leu Arg Ala Arg Ile Gly Asn Val Arg Ala Pro Ile Ala Glu 
                325                 330                 335     


Leu Gln Lys Arg Gly Ile Leu Val Asp Arg Asp Glu Asp Gly Tyr Leu 
            340                 345                 350         


Leu Gln Ile Phe Thr Lys Pro Leu Val Asp Arg Pro Thr Val Phe Phe 
        355                 360                 365             


Glu Leu Ile Glu Arg His Gly Ser Leu Gly Phe Gly Ile Gly Asn Phe 
    370                 375                 380                 


Lys Ala Leu Phe Glu Ala Ile Glu Arg Glu Gln Ala Ala Arg Gly Asn 
385                 390                 395                 400 


Phe 
    


<210>  77
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  histidine tag

<400>  77
catcaccatc accatcac                                                     18


<210>  78
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  78

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Glu Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  79
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  79

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Glu Tyr 
            340                 345                 350         


Asn Phe Gly Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  80
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  80

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ala Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly His Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  81
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  81

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ala Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Ile Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly His Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  82
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  82

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Gly Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  83
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  83

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly His Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  84
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  84

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Ile Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  85
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  85

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Ile Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly His Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Tyr 
            340                 345                 350         


Asn Phe Lys Gly Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  86
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  86

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ala Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Ser Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly His Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Ala Tyr 
            340                 345                 350         


Asn Phe Lys Ala Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  87
<211>  373
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  87

Met Asn Ala Pro Leu Thr Gln Ser Asn Ala Ser Gln Phe Gln Thr Trp 
1               5                   10                  15      


Asp Asn Pro Met Gly Thr Asp Gly Phe Glu Phe Val Glu Tyr Ala Ala 
            20                  25                  30          


Pro Asp Pro Val Ala Met Gly Gln Leu Phe Glu Arg Met Gly Phe Gln 
        35                  40                  45              


Ala Ile Ala Lys His Arg Arg Lys Asn Val Thr Leu Tyr Arg Gln Gly 
    50                  55                  60                  


Glu Ile Asn Phe Ile Ile Asn Ala Glu Pro Asp Ser Phe Ala Gln Arg 
65                  70                  75                  80  


Phe Ala Arg Leu His Gly Pro Ser Val Cys Ala Ile Ala Ile Arg Val 
                85                  90                  95      


Asn Asp Ala Lys Tyr Ala Tyr Glu Arg Ala Thr Ser Leu Gly Ala Trp 
            100                 105                 110         


Gly Tyr Ala Gln Gln Ala Ala Pro Gly Glu Leu Ser Ile Pro Ala Ile 
        115                 120                 125             


Lys Gly Ile Gly Asp Ser Leu Ile Tyr Phe Ile Asp Lys Trp Arg Gly 
    130                 135                 140                 


Lys Asn Gly Ala Lys Asp Gly Asp Leu Gly Asn Ile Ser Phe Phe Asp 
145                 150                 155                 160 


Val Asp Phe Glu Pro Leu Pro Gly Ala Asp Leu His Pro Glu Gly Leu 
                165                 170                 175     


Gly Leu Thr Tyr Ile Asp His Leu Thr Asn Asn Val Tyr Arg Gly Arg 
            180                 185                 190         


Met Ala Glu Leu Ala Glu Phe Tyr Glu Arg Ile Phe Asn Phe Arg Glu 
        195                 200                 205             


Ile Arg Tyr Phe Asp Ile Glu Gly Gln Ala Thr Gly Val Lys Ser Lys 
    210                 215                 220                 


Ala Met Thr Ser Pro Cys Gly Lys Ile Arg Ile Pro Ile Asn Glu Glu 
225                 230                 235                 240 


Gly Asn Asp Lys Ala Gly Gln Ile Gln Glu Tyr Leu Asp Met Tyr Arg 
                245                 250                 255     


Gly Glu Gly Ile Gln His Ile Ala Leu Gly Ser Thr Asn Leu Tyr Asp 
            260                 265                 270         


Thr Val Asp Gly Leu Gln Met Asn Gly Ile Lys Leu Leu Asn Thr Ser 
        275                 280                 285             


Glu Thr Tyr Tyr Glu Leu Leu Pro Lys Arg Ile Pro Asp Leu Gln Glu 
    290                 295                 300                 


Pro Ile Pro Glu Leu Leu Ala Arg Asn Ile Leu Val Asp Gly Gln Pro 
305                 310                 315                 320 


Gly Glu Leu Leu Leu Gln Ile Phe Ser Glu Asn Gln Leu Gly Pro Ile 
                325                 330                 335     


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asn Ser Gly Phe Gly Pro Trp 
            340                 345                 350         


Asn Phe Ala Gln Leu Phe Glu Thr Met Glu Leu Asp Gln Met Arg Arg 
        355                 360                 365             


Gly Val Leu Lys Thr 
    370             


<210>  88
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant HPPD

<400>  88

Met Ala Asp Leu Tyr Glu Asn Pro Met Gly Leu Met Gly Phe Glu Phe 
1               5                   10                  15      


Ile Glu Phe Ala Ser Pro Thr Pro Gly Thr Leu Glu Pro Ile Phe Glu 
            20                  25                  30          


Ile Met Gly Phe Thr Lys Val Ala Thr His Arg Ser Lys Asn Val His 
        35                  40                  45              


Leu Tyr Arg Gln Gly Ala Ile Asn Leu Ile Leu Asn Asn Glu Pro His 
    50                  55                  60                  


Ser Val Ala Ser Tyr Phe Ala Ala Glu His Gly Pro Ser Val Cys Gly 
65                  70                  75                  80  


Met Ala Phe Arg Val Lys Asp Ser Gln Lys Ala Tyr Asn Arg Ala Leu 
                85                  90                  95      


Glu Leu Gly Ala Gln Pro Ile His Ile Glu Thr Gly Pro Met Glu Leu 
            100                 105                 110         


Asn Leu Pro Ala Ile Lys Gly Ile Gly Gly Ala Pro Leu Tyr Leu Ile 
        115                 120                 125             


Asp Arg Phe Gly Glu Gly Ser Ser Ile Tyr Asp Ile Asp Phe Val Phe 
    130                 135                 140                 


Leu Glu Gly Val Asp Arg Asn Pro Val Gly Ala Gly Leu Lys Ile Ile 
145                 150                 155                 160 


Asp His Leu Thr His Asn Val Tyr Arg Gly Arg Met Ala Tyr Trp Ala 
                165                 170                 175     


Asn Phe Tyr Glu Lys Leu Phe Asn Phe Arg Glu Ile Arg Tyr Phe Asp 
            180                 185                 190         


Ile Lys Gly Glu Tyr Thr Gly Leu Thr Ser Lys Ala Met Thr Ala Pro 
        195                 200                 205             


Asp Gly Met Ile Arg Ile Pro Leu Asn Glu Glu Ser Ser Lys Gly Ala 
    210                 215                 220                 


Gly Gln Ile Glu Glu Phe Leu Met Gln Phe Asn Gly Glu Gly Ile Gln 
225                 230                 235                 240 


His Val Ala Phe Leu Thr Asp Asp Leu Val Lys Thr Trp Asp Gln Leu 
                245                 250                 255     


Lys Lys Ile Gly Met Arg Phe Met Thr Ala Pro Pro Asp Thr Tyr Tyr 
            260                 265                 270         


Glu Met Leu Glu Gly Arg Leu Pro Asn His Gly Glu Pro Val Asp Gln 
        275                 280                 285             


Leu Gln Ser Arg Gly Ile Leu Leu Asp Gly Ala Ser Asp Lys Glu Asp 
    290                 295                 300                 


Lys Arg Leu Leu Leu Gln Ile Phe Ser Glu Thr Leu Met Gly Pro Val 
305                 310                 315                 320 


Phe Phe Glu Phe Ile Gln Arg Lys Gly Asp Asp Gly Phe Gly Pro Trp 
                325                 330                 335     


Asn Phe Lys Gly Leu Phe Glu Ser Ile Glu Arg Asp Gln Val Arg Arg 
            340                 345                 350         


Gly Val Leu Ala Thr Glu 
        355             


<210>  89
<211>  2047
<212>  DNA
<213>  Glycine max

<400>  89
ttacagtcac tatcatattt ctatgacggc ctaaccattt tttctttatc caagcaaaga       60

tcgtagaata attttaattt tattagaaga atatattatc tttattaagc ctattaatta      120

agagataaca ggaagcattg gatagcattc tttctttgaa aaaaatggaa tcaatcgggg      180

tgttaatgac ttgcccaatg cacagttaca tccaagaaga gctcgcaaaa cgcttcaacc      240

tcttcaaact ctggcactat ccctcgttct ccgccttcgc ccaagcccac gcccattcca      300

ttcgcgccct cgtcgcaagc gccaaagtcg gagtcgacgc cgccaccatc gattcccttc      360

ccaacctcga gattgtctcc acctacagcg tcggatacga caacatcgac ctccacaaat      420

gcagacacag agcaatcccc gtcaccaaca cgcccaacgt tttaaccgac gacgtggccg      480

acgtagccat cgccctcgcc ttgtccctcc tctgcagaat ttgtccccga aattccactt      540

ggcaattcac accaaagctt agtggtaaag cggttggaat agttgggctg ggaaggattg      600

gttgggcgat tgcgaagaga gccgagggtt ttgggtgtcc agtgagttac cattccagat      660

ctgaaaaatc agagacaggg tataagtatt actctcacat cattgatttg gcggctaact      720

ctgaagtgct ctttgtggcg tgtaccctta gtgaagaaac gcgtcacatt gtgaaccgtg      780

gggttattga tgcgttgggc ccgaaaggga ttctgatcaa tgttgggcga ggcccgcacg      840

tggatgagcc cgaactggtg gccgcgttga ttgaagggag actaggtggg gcgggccttg      900

atgtgtttga gaacgagccg gaggtgcctg aagacctgct ggggcttgag aatcttgtca      960

tgacccctca tgtggggact gacactctgg aaacttgcat cgctatggga gaccttgtaa     1020

ttgctaactt agaggcacac tttcttggca acccactttt cacacctgtc ctttagatcg     1080

ctggctacta ccttgccaga gctcagttac atttcaattt ttctacttca gtgagttgtg     1140

gataacagaa aataaaaata aaaaatcatc cattccactt cctgttcaca aaatgcacat     1200

cacgaattca ttctagataa acacatccca agttatttgt atcaagcgca caaataacca     1260

cccttaaacg atatgaattc atatagaaga gacaatacat agattaagca tcttcatatg     1320

ccatccggat aacatagacc aatagtatgt gcattgatta cttaaactaa aatcttgccc     1380

cgaccaaatt ttttcagaaa tgaaccacga cattggacgg gtggcaatga aaaaggtgca     1440

gtgaagatgc aacatctagt agatgttatc gtccaataga tggtcatatg gaagattgac     1500

cacgagaggg ctggtagtgg cggtgacagt gtacatgatg aggaggagga agctgaagct     1560

tgcgatgaca tggaagctga cgacgtctga aggaggataa cataatagga aaaggagggg     1620

cagggattgt gtaccgcggg tccatgcaaa cggaacttgg aggcccatgt tgctgatttt     1680

ggccttgcca agttcttgta cgaccctggc gcctctcagt ccatgtcctc cattgctggc     1740

tcctacggct acattgctcc aggggagggg caacaagagt agtggagaca attttcttgc     1800

tgctccaaac attgatcatt cacaggactt tgtgagaaag gatcttaaag aatggttatg     1860

ctggatgagg aacaattttg tggagagatt gagtcacatt tatggaatga tttcaagcca     1920

aaacttcata ggaggtgatc attgtatgac gttaaaggaa acagacatag agtaagtgta     1980

aatctgattg gagaacaact ttttatgaca cgaaattgat ttgaactgag gatgttttat     2040

aatttca                                                               2047


<210>  90
<211>  1235
<212>  DNA
<213>  Glycine max

<400>  90
gtctgactcc gagtctgtct ttgttgcgtt tcgagtgtct gtggaatccc taaccctaat       60

ttattgtgtg gcgaaatgag atcaattggg gtactcctgg tggctcaggt gataccgtac      120

ctggagcaag agctggacaa gcgctacaag ctgtttcggg cgtatgatca gccgcagacg      180

gcgcaggttc taagccagca cgcgagctcg atccgtgcgg tggtcggaaa ctcgaacgcc      240

ggcgccgacg cggagctgat cgaggcgctg ccgaagctgg agatcgtgtc gagcttcagc      300

gtgggagtgg acaggataga cctggacagg tgcaaggaga aaggaattcg cgtcaccaac      360

acgccggacg tgctgaccga tgaagtcgcc gacctcgcta tcggattgat gctggcgctg      420

ctcaggagga tctgcgagtg cgatcgttat gtcaggagcg gcaagtggaa gaaaggggac      480

tacaaactga ccactaagtt ctctgggaaa actgttggca ttattgggct agggaggatt      540

ggtcaagcaa ttgctaagag agctgaagga ttcaactgcc ccatatgcta ctactctaga      600

actcaaaaaa gagactcaaa ctacaagtac tatcctagtg ttgtagaact ggcatctaac      660

tgcgacatac tggtagttgc ttgcccactg acggaggaaa ctcatcacat catcaacagg      720

gaggtgatca atgcactggg tcccaagggt tatcttatta acattggacg aggcaagcat      780

gttgatgagg cagagttagt gccagctctg ctagaaggtc gtttgggtgg tgctgggcta      840

gatgtgtttg aaaatgagcc tactgttcca gaagagctat ttgggcttga aaatgttgtc      900

ttgttgcctc atgtcggaag tggcacaata gaaactcgaa ctgccatggc tgaccttgtc      960

cttggaaacc tagacgctca tttccttgga aatccactgt taacaccctt ggtttaatca     1020

atatgccatc atggaactac caggactgat tgtccccctg cattactacc gtttaataac     1080

tttttgtgac atggaaattg atcattgtaa gagcttcttc atatttgtgc tggtgcttaa     1140

tctattgtaa acaatgattt agttcacctt cattgtgaca tcttaataag attatcaatc     1200

attcaatatt gatcgacaaa aaaaaaaaaa aaaaa                                1235


<210>  91
<211>  608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hdrGm-hpf1 concatemer

<400>  91
ttagtggtaa agcggttgga atagttgggc tgggaaggat tggttgggcg attgcgaaga       60

gagccgaggg ttttgggtgt ccagtgagtt accattccag atctgaaaaa tcagagacag      120

ggtataagta ttactctcac atcattgatt tggcggctaa ctctgaagtg ctctttgtgg      180

cgtgtaccct tagtgaagaa acgcgtcaca ttgtgaaccg tggggttatt gatgcgttgg      240

gcccgaaagg gattctgatc aatgttgggc gaggcccgca cgtggatgag cccgaactgg      300

tggccgcaaa ctgttggcat tattgggcta gggaggattg gtcaagcaat tgctaagaga      360

gctgaaggat tcaactgccc catatgctac tactctagaa ctcaaaaaag agactcaaac      420

tacaagtact atcctagtgt tgtagaactg gcatctaact gcgacatact ggtagttgct      480

tgcccactga cggaggaaac tcatcacatc atcaacaggg aggtgatcaa tgcactgggt      540

cccaagggtt atcttattaa cattggacga ggcaagcatg ttgatgaggc agagttagtg      600

ccagctcg                                                               608


<210>  92
<211>  303
<212>  PRT
<213>  Glycine max

<400>  92

Met Glu Ser Ile Gly Val Leu Met Thr Cys Pro Met His Ser Tyr Ile 
1               5                   10                  15      


Gln Glu Glu Leu Ala Lys Arg Phe Asn Leu Phe Lys Leu Trp His Tyr 
            20                  25                  30          


Pro Ser Phe Ser Ala Phe Ala Gln Ala His Ala His Ser Ile Arg Ala 
        35                  40                  45              


Leu Val Ala Ser Ala Lys Val Gly Val Asp Ala Ala Thr Ile Asp Ser 
    50                  55                  60                  


Leu Pro Asn Leu Glu Ile Val Ser Thr Tyr Ser Val Gly Tyr Asp Asn 
65                  70                  75                  80  


Ile Asp Leu His Lys Cys Arg His Arg Ala Ile Pro Val Thr Asn Thr 
                85                  90                  95      


Pro Asn Val Leu Thr Asp Asp Val Ala Asp Val Ala Ile Ala Leu Ala 
            100                 105                 110         


Leu Ser Leu Leu Cys Arg Ile Cys Pro Arg Asn Ser Thr Trp Gln Phe 
        115                 120                 125             


Thr Pro Lys Leu Ser Gly Lys Ala Val Gly Ile Val Gly Leu Gly Arg 
    130                 135                 140                 


Ile Gly Trp Ala Ile Ala Lys Arg Ala Glu Gly Phe Gly Cys Pro Val 
145                 150                 155                 160 


Ser Tyr His Ser Arg Ser Glu Lys Ser Glu Thr Gly Tyr Lys Tyr Tyr 
                165                 170                 175     


Ser His Ile Ile Asp Leu Ala Ala Asn Ser Glu Val Leu Phe Val Ala 
            180                 185                 190         


Cys Thr Leu Ser Glu Glu Thr Arg His Ile Val Asn Arg Gly Val Ile 
        195                 200                 205             


Asp Ala Leu Gly Pro Lys Gly Ile Leu Ile Asn Val Gly Arg Gly Pro 
    210                 215                 220                 


His Val Asp Glu Pro Glu Leu Val Ala Ala Leu Ile Glu Gly Arg Leu 
225                 230                 235                 240 


Gly Gly Ala Gly Leu Asp Val Phe Glu Asn Glu Pro Glu Val Pro Glu 
                245                 250                 255     


Asp Leu Leu Gly Leu Glu Asn Leu Val Met Thr Pro His Val Gly Thr 
            260                 265                 270         


Asp Thr Leu Glu Thr Cys Ile Ala Met Gly Asp Leu Val Ile Ala Asn 
        275                 280                 285             


Leu Glu Ala His Phe Leu Gly Asn Pro Leu Phe Thr Pro Val Leu 
    290                 295                 300             


<210>  93
<211>  313
<212>  PRT
<213>  Glycine max

<400>  93

Met Arg Ser Ile Gly Val Leu Leu Val Ala Gln Val Ile Pro Tyr Leu 
1               5                   10                  15      


Glu Gln Glu Leu Asp Lys Arg Tyr Lys Leu Phe Arg Ala Tyr Asp Gln 
            20                  25                  30          


Pro Gln Thr Ala Gln Val Leu Ser Gln His Ala Ser Ser Ile Arg Ala 
        35                  40                  45              


Val Val Gly Asn Ser Asn Ala Gly Ala Asp Ala Glu Leu Ile Glu Ala 
    50                  55                  60                  


Leu Pro Lys Leu Glu Ile Val Ser Ser Phe Ser Val Gly Val Asp Arg 
65                  70                  75                  80  


Ile Asp Leu Asp Arg Cys Lys Glu Lys Gly Ile Arg Val Thr Asn Thr 
                85                  90                  95      


Pro Asp Val Leu Thr Asp Glu Val Ala Asp Leu Ala Ile Gly Leu Met 
            100                 105                 110         


Leu Ala Leu Leu Arg Arg Ile Cys Glu Cys Asp Arg Tyr Val Arg Ser 
        115                 120                 125             


Gly Lys Trp Lys Lys Gly Asp Tyr Lys Leu Thr Thr Lys Phe Ser Gly 
    130                 135                 140                 


Lys Thr Val Gly Ile Ile Gly Leu Gly Arg Ile Gly Gln Ala Ile Ala 
145                 150                 155                 160 


Lys Arg Ala Glu Gly Phe Asn Cys Pro Ile Cys Tyr Tyr Ser Arg Thr 
                165                 170                 175     


Gln Lys Arg Asp Ser Asn Tyr Lys Tyr Tyr Pro Ser Val Val Glu Leu 
            180                 185                 190         


Ala Ser Asn Cys Asp Ile Leu Val Val Ala Cys Pro Leu Thr Glu Glu 
        195                 200                 205             


Thr His His Ile Ile Asn Arg Glu Val Ile Asn Ala Leu Gly Pro Lys 
    210                 215                 220                 


Gly Tyr Leu Ile Asn Ile Gly Arg Gly Lys His Val Asp Glu Ala Glu 
225                 230                 235                 240 


Leu Val Pro Ala Leu Leu Glu Gly Arg Leu Gly Gly Ala Gly Leu Asp 
                245                 250                 255     


Val Phe Glu Asn Glu Pro Thr Val Pro Glu Glu Leu Phe Gly Leu Glu 
            260                 265                 270         


Asn Val Val Leu Leu Pro His Val Gly Ser Gly Thr Ile Glu Thr Arg 
        275                 280                 285             


Thr Ala Met Ala Asp Leu Val Leu Gly Asn Leu Asp Ala His Phe Leu 
    290                 295                 300                 


Gly Asn Pro Leu Leu Thr Pro Leu Val 
305                 310             


<210>  94
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intron hdrGm

<400>  94
gtttttaatt taatttttat cctcaagaat tctattttca tattctcagt tggatgttac       60

ataatttgcg tgtttttata tttag                                             85


