<110>    PROGEN CO., LTD.

<120>    MODIFIED EGF PROTEIN, PRODUCING METHOD AND USE THEREOF

<130>    PCB809101PRG

<150>    KR 10-2017-0137132
<151>    2017-10-23

<150>    KR 10-2017-0137140
<151>    2017-10-23

<150>    KR 10-2018-0125012
<151>    2018-10-19

<160>    5

<170>    KoPatentIn 3.0

<210>    1
<211>    53
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    EGF(epidermal growth factor) amino acid sequence


<400>    1
Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His
  1               5                  10                  15 

Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn
             20                  25                  30 

Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys
         35                  40                  45 

Trp Trp Glu Leu Arg
     50            


<210>    2
<211>    323
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    EGF-derivative amino acid sequence


<400>    2
Met Asp Ala Met Leu Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly
  1               5                  10                  15 

Ala Val Phe Val Ser Pro Ser His Ala Asn Ser Asp Ser Glu Cys Pro
             20                  25                  30 

Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr Ile
         35                  40                  45 

Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile Gly
     50                  55                  60 

Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg Arg Asn
 65                  70                  75                  80 

Thr Gly Arg Gly Gly Glu Glu Lys Lys Gly Ser Lys Glu Lys Glu Glu
                 85                  90                  95 

Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln
            100                 105                 110 

Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met
        115                 120                 125 

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln
    130                 135                 140 

Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val
145                 150                 155                 160 

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr
                165                 170                 175 

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly
            180                 185                 190 

Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile
        195                 200                 205 

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val
    210                 215                 220 

Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser
225                 230                 235                 240 

Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                245                 250                 255 

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro
            260                 265                 270 

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val
        275                 280                 285 

Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met
    290                 295                 300 

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser
305                 310                 315                 320 

Leu Gly Lys
           


<210>    3
<211>    969
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    EGF-derivative nucleic acid sequence


<400>    3
atggacgcca tgctgagagg cctgtgctgc gtgctgctgc tgtgcggagc cgtgttcgtg         60

agccccagcc acgccaacag cgacagcgag tgccccctga gccacgatgg ctactgcctg        120

cacgatggcg tgtgcatgta catcgaggcc ctggacaagt acgcctgcaa ctgcgtggtg        180

ggctacatcg gcgagaggtg ccagtacaga gacctgaagt ggtgggagct gagaaggaac        240

accggcagag gaggcgagga gaagaaaggc agcaaggaga aggaggagca ggaagagaga        300

gagaccaaga cacccgagtg ccccagccac acccagcccc tgggcgtgtt cctgttccct        360

cccaagccca aagacaccct gatgatcagc agaacacccg aggtgacctg cgtggtcgtg        420

gatgtgagcc aggaagatcc cgaagtgcag ttcaactggt acgtggatgg cgtggaagtg        480

cacaacgcca agaccaagcc cagagaagag cagttcaact ccacctacag agtggtgagc        540

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgtcc        600

aacaaaggcc tgcccagctc catcgagaag accatcagca aagccaaagg ccagcccaga        660

gaaccccagg tgtacaccct gcctcccagc caggaagaga tgaccaagaa ccaggtgtcc        720

ctgacctgcc tggtgaaagg cttctacccc agcgacatcg ccgtggagtg ggaaagcaac        780

ggccagcccg agaacaatta caagacaacc cctcccgtgc tggatagcga tggcagcttc        840

tttctgtaca gcagactgac cgtggacaag agcagatggc aggaaggcaa cgtgttcagc        900

tgcagcgtga tgcacgaagc cctgcacaac cactacaccc agaagagcct gtccctgagc        960

ctgggcaag                                                                969


<210>    4
<211>    298
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    EGF-derivative amino acid sequence


<400>    4
Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His
  1               5                  10                  15 

Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn
             20                  25                  30 

Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys
         35                  40                  45 

Trp Trp Glu Leu Arg Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys
     50                  55                  60 

Gly Ser Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro
 65                  70                  75                  80 

Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro
                 85                  90                  95 

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
            100                 105                 110 

Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp
        115                 120                 125 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
    130                 135                 140 

Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
145                 150                 155                 160 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
                165                 170                 175 

Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
            180                 185                 190 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu
        195                 200                 205 

Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
    210                 215                 220 

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
225                 230                 235                 240 

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                245                 250                 255 

Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn
            260                 265                 270 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
        275                 280                 285 

Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
    290                 295            


<210>    5
<211>    894
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    EGF-derivative nucleic acid sequence


<400>    5
aacagcgaca gcgagtgccc cctgagccac gatggctact gcctgcacga tggcgtgtgc         60

atgtacatcg aggccctgga caagtacgcc tgcaactgcg tggtgggcta catcggcgag        120

aggtgccagt acagagacct gaagtggtgg gagctgagaa ggaacaccgg cagaggaggc        180

gaggagaaga aaggcagcaa ggagaaggag gagcaggaag agagagagac caagacaccc        240

gagtgcccca gccacaccca gcccctgggc gtgttcctgt tccctcccaa gcccaaagac        300

accctgatga tcagcagaac acccgaggtg acctgcgtgg tcgtggatgt gagccaggaa        360

gatcccgaag tgcagttcaa ctggtacgtg gatggcgtgg aagtgcacaa cgccaagacc        420

aagcccagag aagagcagtt caactccacc tacagagtgg tgagcgtgct gaccgtgctg        480

caccaggact ggctgaacgg caaggagtac aagtgcaagg tgtccaacaa aggcctgccc        540

agctccatcg agaagaccat cagcaaagcc aaaggccagc ccagagaacc ccaggtgtac        600

accctgcctc ccagccagga agagatgacc aagaaccagg tgtccctgac ctgcctggtg        660

aaaggcttct accccagcga catcgccgtg gagtgggaaa gcaacggcca gcccgagaac        720

aattacaaga caacccctcc cgtgctggat agcgatggca gcttctttct gtacagcaga        780

ctgaccgtgg acaagagcag atggcaggaa ggcaacgtgt tcagctgcag cgtgatgcac        840

gaagccctgc acaaccacta cacccagaag agcctgtccc tgagcctggg caag              894
