                         SEQUENCE LISTING

<110>  PFIZER INC.
       Charati, Manoj Baburao
       Han, Yoon-Chi
       Katragadda, Madan
       Pich-Nicholas, Nicole Melissa
       Tumey, L. Nathan
 
<120>  ANTIBODIES AND ANTIBODY-DRUG CONJUGATES SPECIFIC FOR CD123 AND 
       USES THEREOF

<130>  PC72333

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu 
            20                  25                  30          


Arg Met Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn 
        35                  40                  45              


Val Thr Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala 
    50                  55                  60                  


Val Asn Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val 
65                  70                  75                  80  


Thr Asn Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile 
                85                  90                  95      


Leu Phe Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            100                 105                 110         


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        115                 120                 125             


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    130                 135                 140                 


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
145                 150                 155                 160 


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                165                 170                 175     


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            180                 185                 190         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        195                 200                 205             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    210                 215                 220                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
225                 230                 235                 240 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                245                 250                 255     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            260                 265                 270         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        275                 280                 285             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    290                 295                 300                 


Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala Leu 
305                 310                 315                 320 


Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg Leu 
                325                 330                 335     


Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe Gln 
            340                 345                 350         


Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu Glu 
        355                 360                 365             


Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    370                 375                 380 


<210>  2
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Lys Glu Asp Pro Asn Pro Pro Ile Thr Asn Leu 
            20                  25                  30          


Arg Met Lys Ala Lys Ala Gln Gln Leu Thr Trp Asp Leu Asn Arg Asn 
        35                  40                  45              


Val Thr Asp Ile Glu Cys Val Lys Asp Ala Asp Tyr Ser Met Pro Ala 
    50                  55                  60                  


Val Asn Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu Val 
65                  70                  75                  80  


Thr Asn Tyr Thr Val Arg Val Ala Asn Pro Pro Phe Ser Thr Trp Ile 
                85                  90                  95      


Leu Phe Pro Glu Asn Ser Gly Lys Pro Trp Ala Gly Ala Glu Asn Leu 
            100                 105                 110         


Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala Val 
        115                 120                 125             


Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn Val 
    130                 135                 140                 


Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp Ala 
145                 150                 155                 160 


Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu Ser 
                165                 170                 175     


Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala Ala 
            180                 185                 190         


Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile Glu 
        195                 200                 205             


Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His Ser 
    210                 215                 220                 


Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg Tyr 
225                 230                 235                 240 


Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln Val 
                245                 250                 255     


Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr Val 
            260                 265                 270         


Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp Ser 
        275                 280                 285             


Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr Arg 
    290                 295                 300                 


Ala Trp Arg Gly Gly Pro Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
305                 310                 315                 320 


Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                325                 330                 335     


<210>  3
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Thr Lys Glu Gly Lys Pro Trp Ala Gly Ala Glu Asn 
            20                  25                  30          


Leu Thr Cys Trp Ile His Asp Val Asp Phe Leu Ser Cys Ser Trp Ala 
        35                  40                  45              


Val Gly Pro Gly Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn 
    50                  55                  60                  


Val Ala Asn Arg Arg Gln Gln Tyr Glu Cys Leu His Tyr Lys Thr Asp 
65                  70                  75                  80  


Ala Gln Gly Thr Arg Ile Gly Cys Arg Phe Asp Asp Ile Ser Arg Leu 
                85                  90                  95      


Ser Ser Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala 
            100                 105                 110         


Ala Phe Gly Ile Pro Cys Thr Asp Lys Phe Val Val Phe Ser Gln Ile 
        115                 120                 125             


Glu Ile Leu Thr Pro Pro Asn Met Thr Ala Lys Cys Asn Lys Thr His 
    130                 135                 140                 


Ser Phe Met His Trp Lys Met Arg Ser His Phe Asn Arg Lys Phe Arg 
145                 150                 155                 160 


Tyr Glu Leu Gln Ile Gln Lys Arg Met Gln Pro Val Ile Thr Glu Gln 
                165                 170                 175     


Val Arg Asp Arg Thr Ser Phe Gln Leu Leu Asn Pro Gly Thr Tyr Thr 
            180                 185                 190         


Val Gln Ile Arg Ala Arg Glu Arg Val Tyr Glu Phe Leu Ser Ala Trp 
        195                 200                 205             


Ser Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Asn Thr 
    210                 215                 220                 


Arg Ala Trp Arg Thr Ser Leu Leu Ile Ala Leu Gly Thr Leu Leu Ala 
225                 230                 235                 240 


Leu Val Cys Val Phe Val Ile Cys Arg Arg Tyr Leu Val Met Gln Arg 
                245                 250                 255     


Leu Phe Pro Arg Ile Pro His Met Lys Asp Pro Ile Gly Asp Ser Phe 
            260                 265                 270         


Gln Asn Asp Lys Leu Val Val Trp Glu Ala Gly Lys Ala Gly Leu Glu 
        275                 280                 285             


Glu Cys Leu Val Thr Glu Val Gln Val Val Gln Lys Thr 
    290                 295                 300     


<210>  4
<211>  337
<212>  PRT
<213>  Macaca fascicularis

<400>  4

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Gln Thr Lys Glu Asp Pro Asn Ala Pro Ile Arg Asn 
            20                  25                  30          


Leu Arg Met Lys Glu Lys Ala Gln Gln Leu Met Trp Asp Leu Asn Arg 
        35                  40                  45              


Asn Val Thr Asp Val Glu Cys Ile Lys Gly Thr Asp Tyr Ser Met Pro 
    50                  55                  60                  


Ala Met Asn Asn Ser Tyr Cys Gln Phe Gly Ala Ile Ser Leu Cys Glu 
65                  70                  75                  80  


Val Thr Asn Tyr Thr Val Arg Val Ala Ser Pro Pro Phe Ser Thr Trp 
                85                  90                  95      


Ile Leu Phe Pro Glu Asn Ser Gly Thr Pro Arg Ala Gly Ala Glu Asn 
            100                 105                 110         


Leu Thr Cys Trp Val His Asp Val Asp Phe Leu Ser Cys Ser Trp Val 
        115                 120                 125             


Val Gly Pro Ala Ala Pro Ala Asp Val Gln Tyr Asp Leu Tyr Leu Asn 
    130                 135                 140                 


Asn Pro Asn Ser His Glu Gln Tyr Arg Cys Leu His Tyr Lys Thr Asp 
145                 150                 155                 160 


Ala Arg Gly Thr Gln Ile Gly Cys Arg Phe Asp Asp Ile Ala Arg Leu 
                165                 170                 175     


Ser Arg Gly Ser Gln Ser Ser His Ile Leu Val Arg Gly Arg Ser Ala 
            180                 185                 190         


Ala Val Ser Ile Pro Cys Thr Asp Lys Phe Val Phe Phe Ser Gln Ile 
        195                 200                 205             


Glu Arg Leu Thr Pro Pro Asn Met Thr Gly Glu Cys Asn Glu Thr His 
    210                 215                 220                 


Ser Phe Met His Trp Lys Met Lys Ser His Phe Asn Arg Lys Phe Arg 
225                 230                 235                 240 


Tyr Glu Leu Arg Ile Gln Lys Arg Met Gln Pro Val Arg Thr Glu Gln 
                245                 250                 255     


Val Arg Asp Thr Thr Ser Phe Gln Leu Pro Asn Pro Gly Thr Tyr Thr 
            260                 265                 270         


Val Gln Ile Arg Ala Arg Glu Thr Val Tyr Glu Phe Leu Ser Ala Trp 
        275                 280                 285             


Ser Thr Pro Gln Arg Phe Glu Cys Asp Gln Glu Glu Gly Ala Ser Ser 
    290                 295                 300                 


Arg Ala Trp Arg Gly Gly Pro Pro Asp Tyr Lys Asp Asp Asp Asp Lys 
305                 310                 315                 320 


Gly Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                325                 330                 335     


Glu 
    


<210>  5
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  5
caggtgaaac tgaaggagtc aggacctggc ctggtggcgc ccgcacagag tctgtccatt       60

acctgcactg tctctggatt ctcattaacc agtggtgaca taagttggat tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta atatggtctg gcggaggcac aaattataat      180

tctcgtctca tgtccagact gagcatcacc aaggacaact ccaggagtca agtgttctta      240

aaaatgaaca gtctgcaaac tgatgacacc gccatatatt attgtgtaag agattggggt      300

aacttttact ttgactattg gggccaaggc accactctca cagtctcctc a               351


<210>  6
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Val Lys Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ala Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Gly 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Gly Thr Asn Tyr Asn Ser Arg Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Arg Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Trp Gly Asn Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  7
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Phe Ser Leu Thr Ser Gly Asp Ile Ser 
1               5                   10  


<210>  8
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  8

Val Ile Trp Ser Gly Gly Gly Thr Asn Tyr Asn Ser Arg Leu Met Ser 
1               5                   10                  15      


<210>  9
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  9

Asp Trp Gly Asn Phe Tyr Phe Asp Tyr 
1               5                   


<210>  10
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  10

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  11
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Pro Lys Ser Cys Asp Arg Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  13
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Leu 
    50                  55                  60                  


Leu Gln Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  14
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  15
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  15

Gln Val Lys Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ala Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Gly 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Gly Thr Asn Tyr Asn Ser Arg Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Arg Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Trp Gly Asn Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Arg Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Leu Leu Gln Gly Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  16
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  16
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagtaggaga gaaggtcact       60

atgagctgca aatccagtca gagtctgctc agcagtggaa cccgaaagaa ctacttggct      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      180

caatctgggg tccctgatcg cttcacaggc ggtggatctg ggacagattt cactctcacc      240

atcagcagtg tgcaggctga ggacctggca gtttattact gcagtcaatc ttataatcta      300

tacacattcg gaggggggac caagctggaa ataaaa                                336


<210>  17
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Ser Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Ser Ser Gln Ser Leu Leu Ser Ser Gly Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  19

Trp Ala Ser Thr Arg Gln Ser 
1               5           


<210>  20
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  20

Ser Gln Ser Tyr Asn Leu Tyr Thr 
1               5               


<210>  21
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  22
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  23
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  23

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Ser Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  24
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Ser Gly 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Gly Gly Gly Thr Asn Tyr Gly Ser Arg Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Trp Gly Asn Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  25
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Ile Trp Ser Gly Gly Gly Thr Asn Tyr Gly Ser Arg Leu Met Ser 
1               5                   10                  15      


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  26

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  27
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Ser Gly 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Gly Gly Gly Thr Asn Tyr Gly Ser Arg Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Trp Gly Asn Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Arg Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Leu Leu Gln Gly Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  28
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  30
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gln Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  31
<211>  355
<212>  DNA
<213>  Mus musculus

<400>  31
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccata       60

acctgcactg tctctgggtt ctcattaacc aactttgata taagttggat tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagta atgtggactg gtggaggcac aaattataat      180

tcagctttca tgtccagact gagcatcagc agggacatct ccaaaagcca agtttcctta      240

aaaatgagca gtctgcaaac tgatgacaca gccatatatt actgtgtaag aggggatact      300

tacttctttg ctatggacta ctggggtcaa ggaacctccg tcaccgtctc atcag           355


<210>  32
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Phe 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Ile Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Asp Thr Tyr Phe Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  33
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  33

Gly Phe Ser Leu Thr Asn Phe Asp Ile Ser 
1               5                   10  


<210>  34
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  34

Val Met Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met Ser 
1               5                   10                  15      


<210>  35
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  35

Gly Asp Thr Tyr Phe Phe Ala Met Asp Tyr 
1               5                   10  


<210>  36
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  36

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  37
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  37

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Phe 
            20                  25                  30          


Asp Ile Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Ile Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Met Ser Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Asp Thr Tyr Phe Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Arg Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Leu Leu Gln Gly Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  38
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  38
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca aatccagtca gagtctgctc agcagtggaa cccgaaagaa cttcttgtct      120

tggtatcagc agaaaccagg gaaagcccct aagctcctga tctattgggc atccactagg      180

ggatctgggg tcccatcaag gttcagtggc agtggatctg ggacagattt cactctcacc      240

atcagcagtc tgcaacctga agattttgca acttactact gtaaacaatc ttataatcta      300

tacacgtttg gccaggggac caagctggag atcaaa                                336


<210>  39
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  39

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Phe Leu Ser Trp Tyr Gln Gln Lys Thr Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Thr Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  40
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  40

Lys Ser Ser Gln Ser Leu Leu Ser Ser Gly Thr Arg Lys Asn Phe Leu 
1               5                   10                  15      


Ser 
    


<210>  41
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  41

Trp Ala Ser Thr Arg Gly Ser 
1               5           


<210>  42
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  42

Lys Gln Ser Tyr Asn Leu Tyr Thr 
1               5               


<210>  43
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  43

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Phe Leu Ser Trp Tyr Gln Gln Lys Thr Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Thr Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  44
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Phe 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Trp Thr Gly Gly Gly Thr Asn Tyr Gln Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Val Tyr Phe Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  45
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  45

Val Met Trp Thr Gly Gly Gly Thr Asn Tyr Gln Ser Ala Phe Met Ser 
1               5                   10                  15      


<210>  46
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Asp Val Tyr Phe Phe Ala Met Asp Tyr 
1               5                   10  


<210>  47
<211>  447
<212>  PRT
<213>  Homo sapiens

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Phe 
            20                  25                  30          


Asp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Met Trp Thr Gly Gly Gly Thr Asn Tyr Gln Ser Ala Phe Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Asp Val Tyr Phe Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Arg Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Leu Leu Gln Gly Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  48
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  49
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Ser Ser 
            20                  25                  30          


Gly Thr Arg Lys Asn Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Gly Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  50
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  50
gaggtccagc tacaacagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagatg       60

tcctgtaagg cttctggata caccttcagt gactacttca tgaagtgggt gaaacagagc      120

catggaaaga gacttgagtg gattggagat attaatccta acaatggtga aactttctac      180

aaccatcatt tcaagggcaa ggccacattg acaatagaca aatcctccag tacagcctac      240

atgcagctca acagcctgac atctgacgac tctgcagtct attactgtgc aagaccccgg      300

cgggggaatg ctatggactt ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  51
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  51

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn His His Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Arg Gly Asn Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  52
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  52

Gly Tyr Thr Phe Ser Asp Tyr Phe Met Lys 
1               5                   10  


<210>  53
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  53

Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn His His Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  54

Pro Arg Arg Gly Asn Ala Met Asp Phe 
1               5                   


<210>  55
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  55

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asp Tyr 
            20                  25                  30          


Phe Met Lys Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Asn Asn Gly Glu Thr Phe Tyr Asn His His Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ile Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Arg Arg Gly Asn Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Arg Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Leu Leu Gln Gly Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  56
<211>  339
<212>  DNA
<213>  Mus musculus

<400>  56
gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcacc       60

atgagctgca agtccagtca gagcctttta aatagaggca atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg acagtctcct aaatttctgg tatattttgc atccactagg      180

gaatctgggg tccctgatcg cttcataggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gattattttt gtcagcaaca ttatagtatt      300

ccgtacacgt tcggaggggg gaccaagctg gaaatacaa                             339


<210>  57
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  57

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Arg 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Phe Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Gln 
    


<210>  58
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  58

Lys Ser Ser Gln Ser Leu Leu Asn Arg Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  59
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  59

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  60

Gln Gln His Tyr Ser Ile Pro Tyr Thr 
1               5                   


<210>  61
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  61

Phe Gly Gly Gly Thr Lys Leu Glu Ile Gln 
1               5                   10  


<210>  62
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  62

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Arg 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Phe Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Gln Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  63
<211>  369
<212>  DNA
<213>  Mus musculus

<400>  63
gaagtacagc tgcagcagtc tgggcccgag cttcggagac ctgggacctc agtcaagctg       60

tcttgtaagg cttctggcta cagtattaca gatttcctta tgtactgggt aaaacatagg      120

ccagaatacg gcctggaatg gattggatgg attgatcctg aggatggtga aacaaaatat      180

gctcagaagt tccaaagcaa ggcccgactg actgcagata cgtcctccaa aacagcctac      240

atggaactca gcagcctgac gtctgaggac acagcaacct atttttgtgc tagatggggc      300

tatatcacgg attatttcta tggcgggttt acttactggg gccgaggcac tctggtcact      360

gtctcttca                                                              369


<210>  64
<211>  123
<212>  PRT
<213>  Mus musculus

<400>  64

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Arg Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Asp Phe 
            20                  25                  30          


Leu Met Tyr Trp Val Lys His Arg Pro Glu Tyr Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Arg Leu Thr Ala Asp Thr Ser Ser Lys Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Trp Gly Tyr Ile Thr Asp Tyr Phe Tyr Gly Gly Phe Thr Tyr 
            100                 105                 110         


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  65
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  65

Gly Tyr Ser Ile Thr Asp Phe Leu Met Tyr 
1               5                   10  


<210>  66
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  66

Trp Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Ser 
    


<210>  67
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  67

Trp Gly Tyr Ile Thr Asp Tyr Phe Tyr Gly Gly Phe Thr Tyr 
1               5                   10                  


<210>  68
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  68

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Asp Phe 
            20                  25                  30          


Leu Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Glu Asp Gly Glu Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Ser Lys Ala Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Trp Gly Tyr Ile Thr Asp Tyr Phe Tyr Gly Gly Phe 
            100                 105                 110         


Thr Tyr Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
    130                 135                 140                 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
        195                 200                 205             


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
    210                 215                 220                 


Pro Lys Ser Cys Asp Arg Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
225                 230                 235                 240 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        275                 280                 285             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Leu Leu Gln 
    290                 295                 300                 


Gly Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            340                 345                 350         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        355                 360                 365             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    370                 375                 380                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
385                 390                 395                 400 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                405                 410                 415     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            420                 425                 430         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        435                 440                 445             


Leu Ser Leu Ser Pro Gly 
    450                 


<210>  70
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  70
gacatccaga tgacccagtc tcctccagtc ctgtctgcat ctgtgggaga cagagtcact       60

ctcagctgca aagcaagtca gaatattaat aagaacttag actggtatca gcaaaagcat      120

ggagaagctc caaaactcct gatatatcat acaaacactt tgcaaatggg catcccatca      180

aggttcagtg gcagtggatc tggtacagat tacgcactca ccatcaccag cctgcagcct      240

gaagatgttg ccacatatta ctgctatcaa tataacagtg ggcccacgtt tggagctggg      300

accaagctgg aactgaga                                                    318


<210>  71
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Pro Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys His Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Asn Thr Leu Gln Met Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ala Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105     


<210>  72
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  72

Lys Ala Ser Gln Asn Ile Asn Lys Asn Leu Asp 
1               5                   10      


<210>  73
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  73

His Thr Asn Thr Leu Gln Met 
1               5           


<210>  74
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  74

Tyr Gln Tyr Asn Ser Gly Pro Thr 
1               5               


<210>  75
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  75

Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
1               5                   10  


<210>  76
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  76

Asp Ile Gln Met Thr Gln Ser Pro Pro Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys His Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Asn Thr Leu Gln Met Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ala Leu Thr Ile Thr Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  77

Gln Leu Gln Gly Leu Leu Gln Gly Gly 
1               5                   


<210>  78
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  78

Leu Leu Gln Gly 
1               


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  79

Leu Ser Leu Ser Gln Gly 
1               5       


<210>  80
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  80

Gly Gly Gly Leu Leu Gln Gly Gly 
1               5               


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONTRUCT

<400>  81

Gly Leu Leu Gln Gly 
1               5   


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  82

Leu Leu Gln Gly Ser Pro Leu Ala Gln Ser His Gly Gly 
1               5                   10              


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  83

Gly Leu Leu Gln Gly Gly Gly 
1               5           


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  84

Gly Leu Leu Gln Gly Gly 
1               5       


<210>  85
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  85

Gly Leu Leu Gln 
1               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  86

Leu Leu Gln Leu Leu Gln Gly Ala 
1               5               


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  87

Leu Leu Gln Gly Ala 
1               5   


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  88

Leu Leu Gln Tyr Gln Gly Ala 
1               5           


<210>  89
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  89

Leu Leu Gln Gly Ser Gly 
1               5       


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  90

Leu Leu Gln Tyr Gln Gly 
1               5       


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  91

Leu Leu Gln Leu Leu Gln Gly 
1               5           


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  92

Ser Leu Leu Gln Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  93

Leu Leu Gln Leu Gln 
1               5   


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  94

Leu Leu Gln Leu Leu Gln 
1               5       


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  95

Leu Leu Gln Gly Arg 
1               5   


<210>  96
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  96

Leu Leu Gln Gly Pro Pro 
1               5       


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  97

Leu Leu Gln Gly Pro Ala 
1               5       


<210>  98
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  98

Gly Gly Leu Leu Gln Gly Pro Pro 
1               5               


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  99

Gly Gly Leu Leu Gln Gly Ala 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  100

Leu Leu Gln Gly Pro Gly Lys 
1               5           


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  101

Leu Leu Gln Gly Pro Gly 
1               5       


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  102

Leu Leu Gln Gly Pro 
1               5   


<210>  103
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  103

Leu Leu Gln Pro 
1               


<210>  104
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  104

Leu Leu Gln Pro Gly Lys 
1               5       


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  105

Leu Leu Gln Ala Pro Gly Lys 
1               5           


<210>  106
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  106

Leu Leu Gln Gly Ala Pro Gly 
1               5           


<210>  107
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  107

Leu Leu Gln Gly Ala Pro 
1               5       


<210>  108
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHETIC CONSTRUCT

<400>  108

Leu Leu Gln Leu Gln Gly 
1               5       


