                         б
<110>  ＼޹˾
<120>  PD-1PD-L1źŴ;һTϸںϵ׼;
<130>  
<160>  95    
<170>  PatentIn汾3.3
<210>  1
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  1
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly 
            100                 105     
<210>  2
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  2
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  3
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  3
Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  
Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  4
<211>  105
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  4
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          
Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              
Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      
Asp Leu Pro Leu Thr Phe Gly Gly Gly 
            100                 105 
<210>  5
<211>  110
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  5
Gln Val Gln Leu Val Gln Ser Gly Ser Glu Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          
Gly Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Gln Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Thr Asp Ser Gly Glu Ser Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  
Lys Gly Arg Phe Val Phe Ser Leu Asp Thr Ser Val Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Ile Thr Ser Leu Thr Ala Glu Asp Thr Gly Met Tyr Phe Cys 
                85                  90                  95      
Val Arg Val Gly Tyr Asp Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110 
<210>  6
<211>  100
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  6
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              
Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Cys Leu Thr Ile Asn Ser Leu Gln Pro Glu 
65                  70                  75                  80  
Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Phe Pro Leu Thr 
                85                  90                  95      
Phe Gly Gly Gly 
            100 
<210>  7
<211>  109
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Ala Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 
<210>  8
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Leu Ala Ser Gln Thr Ile Gly Thr Trp 
            20                  25                  30          
Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Thr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ser Ile Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  9
<211>  114
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  9
Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          
Gly Thr Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              
Trp Leu Ala Thr Ile Cys Trp Glu Asp Ser Lys Gly Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Ala 
65                  70                  75                  80  
Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Ala Arg Arg Glu Asp Ser Gly Tyr Phe Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         
Gln Gly 
        
<210>  10
<211>  100
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  10
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Gly Gln Asn Val Asn Asn Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              
Phe Asn Ala Asn Ser Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Trp Thr Thr 
                85                  90                  95      
Phe Gly Gly Gly 
            100 
<210>  11
<211>  111
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  11
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          
Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Ala Gly Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Leu Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  
Lys Met Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Ala Tyr Gly Asn Tyr Trp Tyr Ile Asp Val Trp Gly Gln Gly 
            100                 105                 110     
<210>  12
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  12
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              
Asn Tyr Ala Phe His Arg Phe Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  
Glu Asp Val Ala Val Tyr Tyr Cys His Gln Ala Tyr Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  13
<211>  105
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  13
Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser 
1               5                   10                  15      
Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Tyr Gly 
            20                  25                  30          
Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              
Val Ile Trp Tyr Asp Ser Ser Arg Lys Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Thr Asn Asn Asp Tyr Trp Gly Gln Gly 
            100                 105 
<210>  14
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  14
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Asn Tyr 
            20                  25                  30          
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Thr Arg Ala Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Met Gln Leu Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  15
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  15
Asp Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
1               5                   10                  15      
Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Gly Ile 
            20                  25                  30          
Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
        35                  40                  45              
Ile Ser Ala Tyr Asn Gly Asn Thr Asn Tyr Ala Gln Lys Leu Gln Gly 
    50                  55                  60                  
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  
Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      
Gly Arg Gly Tyr Ser Tyr Gly Ile Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  16
<211>  103
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  16
Leu Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly 
1               5                   10                  15      
Gln Thr Ala Arg Ile Thr Cys Ser Gly Asp Ala Leu Pro Lys Gln Tyr 
            20                  25                  30          
Ala Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              
Tyr Lys Asp Ser Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly 
    50                  55                  60                  
Ser Ser Ser Gly Thr Thr Val Thr Leu Thr Ile Ser Gly Val Gln Ala 
65                  70                  75                  80  
Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ala Asp Ser Ser Gly Thr 
                85                  90                  95      
Tyr Val Val Phe Gly Gly Gly 
            100             
<210>  17
<211>  118
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  17
Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Val Ile Glu Ser Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Glu Gly Ile Thr Thr Val Ala Thr Thr Tyr Tyr Trp Tyr Phe 
            100                 105                 110         
Asp Val Trp Gly Gln Gly 
        115             
<210>  18
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  18
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Gln Gly 
            100                 105     
<210>  19
<211>  111
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  19
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Thr Ile Ser Gly Gly Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gln Leu Asn Tyr Ala Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110     
<210>  20
<211>  105
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  20
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      
Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          
Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr Thr Ser Ser Asn Lys Asp Thr Gly Val Pro Ala 
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  
Pro Met Glu Ala Glu Asp Thr Ala Val Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      
Glu Val Pro Trp Thr Phe Gly Gly Gly 
            100                 105 
<210>  21
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Leu Ile Ile Pro Met Phe Asp Thr Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Ala Ile Thr Val Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Glu His Ser Ser Thr Gly Thr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  22
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Ser Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn His Leu Pro Phe 
                85                  90                  95      
Thr Phe Gly Gly Gly 
            100     
<210>  23
<211>  116
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  23
Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Thr Leu Thr Cys Thr Val Ser Ala Asp Ser Ile Ser Ser Thr 
            20                  25                  30          
Thr Tyr Tyr Trp Val Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Ser Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  
Ser Leu Lys Leu Asn Ser Val Ala Ala Thr Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Leu Gly Tyr Asn Gly Arg Tyr Leu Pro Phe Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly 
        115     
<210>  24
<211>  104
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  24
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Phe Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Glu Leu 
        35                  40                  45              
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Asn Ile 
                85                  90                  95      
Ser Thr Trp Val Phe Gly Gly Gly 
            100                 
<210>  25
<211>  106
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  25
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Thr Cys Lys Ala Ser Gly Leu Thr Phe Ser Ser Ser 
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Asn Asn Asp Tyr Trp Gly Gln Gly 
            100                 105     
<210>  26
<211>  102
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1ɱ
<400>  26
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Thr Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ser Asn Trp Pro Arg 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr 
            100         
<210>  27
<211>  111
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-L1ɱ
<400>  27
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110     
<210>  28
<211>  101
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-L1ɱ
<400>  28
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      
Thr Phe Gly Gln Gly 
            100     
<210>  29
<211>  114
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-L1ɱ
<400>  29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly 
        
<210>  30
<211>  102
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-L1ɱ
<400>  30
Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Arg Val Ser Ser Ser 
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              
Ile Tyr Asp Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Leu Pro 
                85                  90                  95      
Trp Thr Phe Gly Gln Gly 
            100         
<210>  31
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-L1ɱ
<400>  31
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly 
    
<210>  32
<211>  104
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-L1ɱ
<400>  32
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      
Ser Thr Arg Val Phe Gly Thr Gly 
            100                 
<210>  33
<211>  113
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1㶨У
<400>  33
Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
1               5                   10                  15      

Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
            20                  25                  30          
Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
        35                  40                  45              
Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
    50                  55                  60                  
Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
65                  70                  75                  80  
Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
                85                  90                  95      
His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105                 110         
Cys 
    
<210>  34
<211>  112
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1㶨У
<400>  34
Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
1               5                   10                  15      
Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
            20                  25                  30          
Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
        35                  40                  45              
Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
    50                  55                  60                  
Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
65                  70                  75                  80  
Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
                85                  90                  95      
His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105                 110         
<210>  35
<211>  337
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1㶨УIgG1
<400>  35
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
            20                  25                  30          
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
                85                  90                  95      
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
            100                 105                 110         
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        115                 120                 125             
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    130                 135                 140                 
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
145                 150                 155                 160 
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                165                 170                 175     
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            180                 185                 190         
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        195                 200                 205             
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    210                 215                 220                 
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
225                 230                 235                 240 
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
                245                 250                 255     
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            260                 265                 270         
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        275                 280                 285             
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    290                 295                 300                 
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
305                 310                 315                 320 
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 330                 335     
Lys 
    
<210>  36
<211>  333
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1㶨УIgG2
<400>  36
Thr Thr Val Thr Val Ser Thr Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
            20                  25                  30          
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  
Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
                85                  90                  95      
Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
            100                 105                 110         
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
        115                 120                 125             
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    130                 135                 140                 
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
145                 150                 155                 160 
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                165                 170                 175     
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
            180                 185                 190         
Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        195                 200                 205             
Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    210                 215                 220                 
Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
225                 230                 235                 240 
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                245                 250                 255     
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            260                 265                 270         
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
        275                 280                 285             
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    290                 295                 300                 
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
305                 310                 315                 320 
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330             
<210>  37
<211>  334
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһֿPD-1㶨УIgG4
<400>  37
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
1               5                   10                  15      
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
            20                  25                  30          
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
        35                  40                  45              
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
    50                  55                  60                  
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
65                  70                  75                  80  
Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
                85                  90                  95      
Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
            100                 105                 110         
Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
        115                 120                 125             
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    130                 135                 140                 
Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
145                 150                 155                 160 
Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                165                 170                 175     
Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
            180                 185                 190         
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        195                 200                 205             
Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
    210                 215                 220                 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
225                 230                 235                 240 
Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                245                 250                 255     
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            260                 265                 270         
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        275                 280                 285             
Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
    290                 295                 300                 
Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
305                 310                 315                 320 
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                325                 330                 
<210>  38
<211>  232
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеIgG1 Fcİ
<400>  38
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10                  15      
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 
Tyr Thr Gln Lys Ser Leu Ser Leu 
225                 230         
<210>  39
<211>  228
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеIgG2 Fcİ
<400>  39
Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10                  15      
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              
Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
    50                  55                  60                  
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  
Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
                85                  90                  95      
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
            100                 105                 110         
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
        115                 120                 125             
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     
Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 
Ser Leu Ser Leu 
225             
<210>  40
<211>  231
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеIgG4 Fcİ
<400>  40
Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15      
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              
Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    50                  55                  60                  
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  
Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         
Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    130                 135                 140                 
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         
Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        195                 200                 205             
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 
Lys Ser Leu Ser Leu Ser Leu 
225                 230     
<210>  41
<211>  112
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеCD80-IgVİ
<400>  41
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         
<210>  42
<211>  208
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеCD80-IgVIgCİ
<400>  42
Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys 
1               5                   10                  15      
Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp 
            20                  25                  30          
Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn 
        35                  40                  45              
Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn 
    50                  55                  60                  
Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr 
65                  70                  75                  80  
Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His 
                85                  90                  95      
Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser 
            100                 105                 110         
Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys 
        115                 120                 125             
Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn 
    130                 135                 140                 
Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu 
145                 150                 155                 160 
Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr 
                165                 170                 175     
Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn 
            180                 185                 190         
Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        195                 200                 205             
<210>  43
<211>  16
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  43
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      
<210>  44
<211>  17
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  44
Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg 
1               5                   10                  15      
Val 
    
<210>  45
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  45
Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   
<210>  46
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  46
Ser Ala Lys Thr Thr Pro Lys Leu Gly Gly 
1               5                   10  
<210>  47
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  47
Ser Ala Lys Thr Thr Pro 
1               5       
<210>  48
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  48
Arg Ala Asp Ala Ala Pro 
1               5       
<210>  49
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  49
Arg Ala Asp Ala Ala Pro Thr Val Ser 
1               5                   
<210>  50
<211>  12
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  50
Arg Ala Asp Ala Ala Ala Ala Gly Gly Pro Gly Ser 
1               5                   10          
<210>  51
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  51
Arg Ala Asp Ala Ala Ala Ala 
1               5           
<210>  52
<211>  18
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  52
Ser Ala Lys Thr Thr Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
1               5                   10                  15      
Arg Val 
        
<210>  53
<211>  5
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  53
Ala Asp Ala Ala Pro 
1               5   
<210>  54
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  54
Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
1               5                   10      
<210>  55
<211>  5
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  55
Thr Val Ala Ala Pro 
1               5   
<210>  56
<211>  12
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  56
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
1               5                   10          
<210>  57
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  57
Gln Pro Lys Ala Ala Pro 
1               5       
<210>  58
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  58
Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro 
1               5                   10              
<210>  59
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  59
Ala Lys Thr Thr Pro Pro 
1               5       
<210>  60
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  60
Ala Lys Thr Thr Pro Pro Ser Val Thr Pro Leu Ala Pro 
1               5                   10              
<210>  61
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  61
Ala Lys Thr Thr Ala Pro 
1               5       
<210>  62
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  62
Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
1               5                   10              
<210>  63
<211>  6
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  63
Ala Ser Thr Lys Gly Pro 
1               5       
<210>  64
<211>  13
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  64
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
1               5                   10              
<210>  65
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  65
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  
<210>  66
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  66
Gly Glu Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser 
1               5                   10                  15  
<210>  67
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  67
Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser 
1               5                   10                  15  
<210>  68
<211>  15
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  68
Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser 
1               5                   10                  15  
<210>  69
<211>  16
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  69
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala 
1               5                   10                  15      
<210>  70
<211>  19
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  70
Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      
Gly Ser Gly 
            
<210>  71
<211>  20
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵеһĽͷ
<400>  71
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  
<210>  72
<211>  723
<212>  DNA
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1L
<400>  72
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgagattgt gctgacacag tcccccgcta ctctgagcct gagccctggc    120
gagagggcta cactgtcttg cagagcttct cagtccgtgt cttcttacct cgcttggtat    180
cagcagaagc ccggccaggc tccaagactg ctgatctatg acgcttctaa ccgcgctaca    240
ggcattcctg ctaggttcag cggcagcggc tctggcaccg acttcacact cacaattagc    300
tctcttgaac ctgaggactt cgccgtgtac tactgccagc agtctagcaa ctggcctaga    360
acattcggcc agggcactaa ggtggagatt aagagaaccg tggccgcccc cagcgtgttc    420
atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg    480
aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    540
ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc    600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg    660
acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaagaa    720
ttc                                                                  723
<210>  73
<211>  234
<212>  PRT
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1L
<400>  73
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
            100                 105                 110         
Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 
<210>  74
<211>  1401
<212>  DNA
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1H
<400>  74
tctagagcca ccatggagac cgacaccctg ctgctgtggg tgctgctcct gtgggtgcct     60
ggctccacag gccaggtgca gctcgtggag tccggcggcg gcgtggtgca gcccggcaga    120
tccctcagac tggactgcaa ggcatccggc attacattct ctaactctgg aatgcactgg    180
gtgagacagg ctcctggcaa gggcctggaa tgggtggccg tgatttggta cgacggctct    240
aagagatact acgctgactc cgtgaagggc cggttcacaa ttagcagaga caactccaag    300
aacactctgt tcctccagat gaacagcctg agagccgagg acaccgctgt gtactactgc    360
gccaccaacg acgactactg gggccagggc accctcgtga cagtgtcttc cgcctccacc    420
aagggccctt ccgtgttccc tctggcccct tgctcccgct ccacctccga gtccaccgcc    480
gccctgggct gcctggtgaa ggactacttc cctgagcctg tgaccgtgtc ctggaactcc    540
ggcgccctga cctccggcgt gcacaccttc cctgccgtgc tgcagtcctc cggcctgtac    600
tccctgtcct ccgtggtgac cgtgccttcc tcctccctgg gcaccaagac ctacacctgc    660
aacgtggacc acaagccttc caacaccaag gtggacaagc gcgtggagtc caagtacggc    720
cctccttgcc ctccttgccc tgcccctgag ttcctgggcg gcccttccgt gttcctgttc    780
cctcctaagc ctaaggacac cctgatgatc tcccgcaccc ctgaggtgac ctgcgtggtg    840
gtggacgtgt cccaggagga ccctgaggtg cagttcaact ggtacgtgga cggcgtggag    900
gtgcacaacg ccaagaccaa gcctcgcgag gagcagttca actccaccta ccgcgtggtg    960
tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg   1020
tccaacaagg gcctgccttc ctccatcgag aagaccatct ccaaggccaa gggccagcct   1080
cgcgagcctc aggtgtacac cctgcctcct tcccaggagg agatgaccaa gaaccaggtg   1140
tccctgacct gcctggtgaa gggcttctac ccttccgaca tcgccgtgga gtgggagtcc   1200
aacggccagc ctgagaacaa ctacaagacc acccctcctg tgctggactc cgacggctcc   1260
ttcttcctgt actcccgcct gaccgtggac aagtcccgct ggcaggaggg caacgtgttc   1320
tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg   1380
tccctgggca agtaagtcga c                                             1401
<210>  75
<211>  460
<212>  PRT
<213>  ˹
<220>  
<223>  PD1BY18.1BY18.1H
<400>  75
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr 
        35                  40                  45              
Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr 
65                  70                  75                  80  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      
Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             
Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 
Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 
Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 460 
<210>  76
<211>  723
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.2,IgG4ĵһǻBY31.2L
<400>  76
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgagattgt gctgacacag tcccccgcta ctctgagcct gagccctggc    120
gagagggcta cactgtcttg cagagcttct cagtccgtgt cttcttacct cgcttggtat    180
cagcagaagc ccggccaggc tccaagactg ctgatctatg acgcttctaa ccgcgctaca    240
ggcattcctg ctaggttcag cggcagcggc tctggcaccg acttcacact cacaattagc    300
tctcttgaac ctgaggactt cgccgtgtac tactgccagc agtctagcaa ctggcctaga    360
acattcggcc agggcactaa ggtggagatt aagagaaccg tggccgcccc cagcgtgttc    420
atcttccctc ccagcgacga gcagctgaag tctggcaccg ccagcgtggt gtgcctgctg    480
aacaacttct acccccgcga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    540
ggcaacagcc aggagagcgt gaccgagcag gactccaagg acagcaccta cagcctgagc    600
agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg    660
acccaccagg gactgtctag ccccgtgacc aagagcttca accggggcga gtgctaagaa    720
ttc                                                                  723
<210>  77
<211>  234
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.2,IgG4ĵһǻBY31.2L
<400>  77
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
            100                 105                 110         
Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 
<210>  78
<211>  1776
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.2,IgG4ĵڶǻBY31.2H
<400>  78
tctagagcca ccatggagac cgacaccctg ctgctgtggg tgctgctcct gtgggtgcct     60
ggctccacag gccaggtgca gctcgtggag tccggcggcg gcgtggtgca gcccggcaga    120
tccctcagac tggactgcaa ggcatccggc attacattct ctaactctgg aatgcactgg    180
gtgagacagg ctcctggcaa gggcctggaa tgggtggccg tgatttggta cgacggctct    240
aagagatact acgctgactc cgtgaagggc cggttcacaa ttagcagaga caactccaag    300
aacactctgt tcctccagat gaacagcctg agagccgagg acaccgctgt gtactactgc    360
gccaccaacg acgactactg gggccagggc accctcgtga cagtgtcttc cgcctccacc    420
aagggccctt ccgtgttccc tctggcccct tgctcccgct ccacctccga gtccaccgcc    480
gccctgggct gcctggtgaa ggactacttc cctgagcctg tgaccgtgtc ctggaactcc    540
ggcgccctga cctccggcgt gcacaccttc cctgccgtgc tgcagtcctc cggcctgtac    600
tccctgtcct ccgtggtgac cgtgccttcc tcctccctgg gcaccaagac ctacacctgc    660
aacgtggacc acaagccttc caacaccaag gtggacaagc gcgtggagtc caagtacggc    720
cctccttgcc ctccttgccc tgcccctgag ttcctgggcg gcccttccgt gttcctgttc    780
cctcctaagc ctaaggacac cctgatgatc tcccgcaccc ctgaggtgac ctgcgtggtg    840
gtggacgtgt cccaggagga ccctgaggtg cagttcaact ggtacgtgga cggcgtggag    900
gtgcacaacg ccaagaccaa gcctcgcgag gagcagttca actccaccta ccgcgtggtg    960
tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg   1020
tccaacaagg gcctgccttc ctccatcgag aagaccatct ccaaggccaa gggccagcct   1080
cgcgagcctc aggtgtacac cctgcctcct tcccaggagg agatgaccaa gaaccaggtg   1140
tccctgacct gcctggtgaa gggcttctac ccttccgaca tcgccgtgga gtgggagtcc   1200
aacggccagc ctgagaacaa ctacaagacc acccctcctg tgctggactc cgacggctcc   1260
ttcttcctgt actcccgcct gaccgtggac aagtcccgct ggcaggaggg caacgtgttc   1320
tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg   1380
tccctgggcg gcggaggatc tggcggcgga ggcagtggag gcggcggaag tgtgatccat   1440
gtaacaaaag aagtgaagga agtggctaca ctctcttgcg gccacaacgt gtccgtggag   1500
gaactagctc agacccggat ctattggcag aaagaaaaga agatggtgct gaccatgatg   1560
tccggcgaca tgaacatttg gccagagtac aagaaccgca caattttcga cattacaaac   1620
aacctctcta ttgtgattct ggctctcagg cctagcgacg agggcacata cgagtgcgtg   1680
gtgctcaagt acgagaagga cgctttcaag cgggagcacc tcgctgaggt gaccctgtcc   1740
gtgaaggccg acttccctac tccatcttaa gtcgac                             1776
<210>  79
<211>  585
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.2,IgG4ĵڶǻBY31.2H
<400>  79
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr 
        35                  40                  45              
Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr 
65                  70                  75                  80  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      
Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             
Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 
Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
225                 230                 235                 240 
Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     

Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ile His Val Thr Lys Glu 
465                 470                 475                 480 
Val Lys Glu Val Ala Thr Leu Ser Cys Gly His Asn Val Ser Val Glu 
                485                 490                 495     
Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val 
            500                 505                 510         
Leu Thr Met Met Ser Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn 
        515                 520                 525             
Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala 
    530                 535                 540                 
Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr 
545                 550                 555                 560 
Glu Lys Asp Ala Phe Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser 
                565                 570                 575     
Val Lys Ala Asp Phe Pro Thr Pro Ser 
            580                 585 
<210>  80
<211>  786
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.3,IgG2ĵһǻBY31.3L
<400>  80
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgagatcaa gcggaccgtg gccgccccat ccgtgttcat tttcccacct    120
tccgagattg tgctgacaca gtcccccgct actctgagcc tgagccctgg cgagagggct    180
acactgtctt gcagagcttc caagggcgtg agcacatccg gctactccta cctccactgg    240
tatcagcaga agccaggcca ggccccaaga ctgctgatat acctcgcttc ttacttagag    300
tctggcgtgc ccgctcggtt cagcggctcc ggctctggca ccgacttcac cctgacaatt    360
tctagcctgg agcccgagga cttcgccgtg tactactgcc agcactctag ggacctgcct    420
ctcacattcg gcggcggcac taaggtggag attaagagaa ccgtggccgc ccccagcgtg    480
ttcatcttcc ctcccagcga cgagcagctg aagtctggca ccgccagcgt ggtgtgcctg    540
ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag    600
agcggcaaca gccaggagag cgtgaccgag caggactcca aggacagcac ctacagcctg    660
agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag    720
gtgacccacc agggactgtc tagccccgtg accaagagct tcaaccgggg cgagtgctaa    780
gaattc                                                               786
<210>  81
<211>  238
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.3,IgG2ĵһǻBY31.3L
<400>  81
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly 
        35                  40                  45              
Val Ser Thr Ser Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  
Gly Gln Ala Pro Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser 
65                  70                  75                  80  
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            100                 105                 110         
Gln His Ser Arg Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val 
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             
<210>  82
<211>  2082
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.3,IgG2ĵڶǻBY31.3H
<400>  82
tctagagcca ccatggagac cgacaccctg ctgctgtggg tgctgctcct gtgggtgcct     60
ggctccacag gccaggtgca gctcgtgcag tctggcgtgg aggtgaagaa gcctggcgcc    120
tctgtgaagg tgtcttgcaa ggcttccggc tacactttca ctaactacta catgtactgg    180
gtgagacagg ctcccggcca gggcctagag tggatgggcg gcattaaccc tagcaacggc    240
ggcacaaact tcaacgagaa gttcaagaac cgcgtgaccc tgaccacaga ctctagcaca    300
acaactgctt acatggagct gaagtctctc cagttcgacg acaccgctgt gtactactgc    360
gctcggaggg actacagatt cgacatgggc ttcgactact ggggccaggg caccactgtg    420
acagtgtcta cagcctccac caagggccct tccgtgttcc ctctggcccc ttgctcccgc    480
tccacctccg agtccaccgc cgccctgggc tgcctggtga aggactactt ccctgagcct    540
gtgaccgtgt cctggaactc cggcgccctg acctccggcg tgcacacctt ccctgccgtg    600
ctgcagtcct ccggcctgta ctccctgtcc tccgtggtga ccgtgccttc ctccaacttc    660
ggcacccaga catacacatg caacgtggac cacaagcctt ctaacacaaa ggtggacaag    720
accgtggagc ggaagtgctg cgtggagtgc ccaccttgcc ccgctcctcc tgtggccggc    780
ccttctgtgt tcctgttccc acctaagcca aaggacacac tcatgatcag cagaacccct    840
gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgca gttcaactgg    900
tatgtggacg gcgtggaggt gcacaacgct aagaccaagc ctagagaaga acagttcaac    960
agcacattca gagtggtgtc cgtgctcacc gtggtgcacc aggactggct gaacggcaaa   1020
gagtacaagt gcaaggtgtc caacaagggc ctgccagccc ctatcgaaaa aacaatcagc   1080
aagaccaagg gccagcctag agagcctcag gtgtacacac tgcctccatc tcgggaagaa   1140
atgacaaaga accaggtgtc cctcacatgc ctcgtgaagg gcttctaccc atccgacatc   1200
gctgtggagt gggagtctaa cggccagccc gagaacaact acaagaccac ccctcctatg   1260
ctcgactccg acggctcttt cttcctgtac tctaagctga ccgtggacaa gtccagatgg   1320
cagcagggca acgtgttctc ttgcagcgtg atgcacgagg ctctccacaa ccactacacc   1380
cagaagtccc tgagcctgtc tccaggcggc ggaggatctg gcggcggagg cagtggaggc   1440
ggcggaagcg tcattcacgt cactaaggag gtcaaggagg tcgcaaccct cagttgcgga   1500
cacaacgtca gcgtggagga gcttgcacag acacgcatct actggcagaa ggagaagaag   1560
atggtgctga ccatgatgtc cggcgatatg aacatttggc cagagtacaa gaatcggacc   1620
atcttcgata ttacaaataa cctgtccatc gtgatcctcg ctctgcgccc tagcgacgag   1680
ggaacatacg agtgtgtggt gctgaagtac gagaaggatg catttaagcg cgagcacctg   1740
gctgaggtga cactctccgt caaggccgat tttcctactc cttctatctc cgactttgag   1800
attccaacat caaatattag gcgcattatc tgttctacat ccggcggatt cccagagccc   1860
cacctctctt ggttggagaa cggcgaggaa cttaatgcta tcaatacaac cgtgtctcaa   1920
gatcccgaga ctgagctgta cgccgtgtct agtaagctgg actttaacat gactaccaat   1980
cacagtttca tgtgcctgat taagtacggc cacctgcggg tgaatcagac ctttaattgg   2040
aatactacca agcaggagca cttcccagat aactaagtcg ac                      2082
<210>  83
<211>  687
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.3,IgG2ĵڶǻBY31.3H
<400>  83
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys 
            20                  25                  30          
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr 
        35                  40                  45              
Phe Thr Asn Tyr Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly 
    50                  55                  60                  
Leu Glu Trp Met Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe 
65                  70                  75                  80  
Asn Glu Lys Phe Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr 
                85                  90                  95      
Thr Thr Ala Tyr Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp 
        115                 120                 125             
Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Thr Ala Ser Thr Lys 
    130                 135                 140                 
Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 
Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             
Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
    210                 215                 220                 
Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
225                 230                 235                 240 
Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
                245                 250                 255     
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
305                 310                 315                 320 
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
            340                 345                 350         
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
                405                 410                 415     
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val 
465                 470                 475                 480 
Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly 
                485                 490                 495     
His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln 
            500                 505                 510         
Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile 
        515                 520                 525             
Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu 
    530                 535                 540                 
Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu 
545                 550                 555                 560 
Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu 
                565                 570                 575     
Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr Pro Ser Ile 
            580                 585                 590         
Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile Ile Cys Ser 
        595                 600                 605             
Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu Glu Asn Gly 
    610                 615                 620                 
Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp Pro Glu Thr 
625                 630                 635                 640 
Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met Thr Thr Asn 
                645                 650                 655     
His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg Val Asn Gln 
            660                 665                 670         
Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro Asp Asn 
        675                 680                 685         
<210>  84
<211>  1116
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.7ĵһǻBY31.7L
<400>  84
tctagagcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgtcatcca tgtgaccaaa gaggtcaaag aagtcgcaac tctgtcttgc    120
ggacacaacg tctccgtcga agaactcgcc cagactagaa tatattggca gaaggaaaag    180
aagatggtgc tcaccatgat gtccggcgat atgaacattt ggcctgagta caagaaccgg    240
acaatcttcg atattactaa taacctgagt atcgtgattc tcgctctgcg ccctagcgac    300
gagggcacat acgagtgtgt ggtgctgaag tacgagaagg atgcattcaa gcgggagcac    360
ctcgcagagg tgacactctc cgtgaaggcc gacttcccaa ccccatctgg ccagggcact    420
aaggtggaga ttaagagagg cggctctggc ggcggaggca gtggagagat tgtgctgaca    480
cagtcccccg ctactctgag cctgagccct ggcgagaggg ctacactgtc ttgcagagct    540
tctcagtccg tgtcttctta cctcgcttgg tatcagcaga agcccggcca ggctccaaga    600
ctgctgatct atgacgcttc taaccgcgct acaggcattc ctgctaggtt cagcggcagc    660
ggctctggca ccgacttcac actcacaatt agctctcttg aacctgagga cttcgccgtg    720
tactactgcc agcagtctag caactggcct agaacattcg gccagggcac taaggtggag    780
attaagagaa ccgtggccgc ccccagcgtg ttcatcttcc ctcccagcga cgagcagctg    840
aagtctggca ccgccagcgt ggtgtgcctg ctgaacaact tctacccccg cgaggccaag    900
gtgcagtgga aggtggacaa cgccctgcag agcggcaaca gccaggagag cgtgaccgag    960
caggactcca aggacagcac ctacagcctg agcagcaccc tgaccctgag caaggccgac   1020
tacgagaagc acaaggtgta cgcctgcgag gtgacccacc agggactgtc tagccccgtg   1080
accaagagct tcaaccgggg cgagtgctaa gtcgac                             1116
<210>  85
<211>  365
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.7ĵһǻBY31.7L
<400>  85
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          
Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              
Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  
Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  
Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      
Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         
Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             
Pro Thr Pro Ser Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Gly Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Ala 
145                 150                 155                 160 
Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
                165                 170                 175     
Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
            180                 185                 190         

Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly 
        195                 200                 205             
Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    210                 215                 220                 
Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln 
225                 230                 235                 240 
Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu 
                245                 250                 255     
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
            260                 265                 270         
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
        275                 280                 285             
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
    290                 295                 300                 
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
305                 310                 315                 320 
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
                325                 330                 335     
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
            340                 345                 350         
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
        355                 360                 365 
<210>  86
<211>  1797
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.7ĵڶǻBY31.7H
<400>  86
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgtcatcca tgtgaccaaa gaggtcaaag aagtcgcaac tctgtcttgc    120
ggacacaacg tctccgtcga agaactcgcc cagactagaa tatattggca gaaggaaaag    180
aagatggtgc tcaccatgat gtccggcgat atgaacattt ggcctgagta caagaaccgg    240
acaatcttcg atattactaa taacctgagt atcgtgattc tcgctctgcg ccctagcgac    300
gagggcacat acgagtgtgt ggtgctgaag tacgagaagg atgcattcaa gcgggagcac    360
ctcgcagagg tgacactctc cgtgaaggcc gacttcccaa ccccatctgg ccagggcaca    420
ctcgtgaccg tgtctagcgg cggcggaggc agtggcggcg gaggcagtca ggtgcagctc    480
gtggagtccg gcggcggcgt ggtgcagccc ggcagatccc tcagactgga ctgcaaggca    540
tccggcatta cattctctaa ctctggaatg cactgggtga gacaggctcc tggcaagggc    600
ctggaatggg tggccgtgat ttggtacgac ggctctaaga gatactacgc tgactccgtg    660
aagggccggt tcacaattag cagagacaac tccaagaaca ctctgttcct ccagatgaac    720
agcctgagag ccgaggacac cgctgtgtac tactgcgcca ccaacgacga ctactggggc    780
cagggcaccc tcgtgacagt gtcttccgcc tccaccaagg gcccttccgt gttccctctg    840
gccccttgct cccgctccac ctccgagtcc accgccgccc tgggctgcct ggtgaaggac    900
tacttccctg agcctgtgac cgtgtcctgg aactccggcg ccctgacctc cggcgtgcac    960
accttccctg ccgtgctgca gtcctccggc ctgtactccc tgtcctccgt ggtgaccgtg   1020
ccttcctcct ccctgggcac caagacctac acctgcaacg tggaccacaa gccttccaac   1080
accaaggtgg acaagcgcgt ggagtccaag tacggccctc cttgccctcc ttgccctgcc   1140
cctgagttcc tgggcggccc ttccgtgttc ctgttccctc ctaagcctaa ggacaccctg   1200
atgatctccc gcacccctga ggtgacctgc gtggtggtgg acgtgtccca ggaggaccct   1260
gaggtgcagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagcct   1320
cgcgaggagc agttcaactc cacctaccgc gtggtgtccg tgctgaccgt gctgcaccag   1380
gactggctga acggcaagga gtacaagtgc aaggtgtcca acaagggcct gccttcctcc   1440
atcgagaaga ccatctccaa ggccaagggc cagcctcgcg agcctcaggt gtacaccctg   1500
cctccttccc aggaggagat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc   1560
ttctaccctt ccgacatcgc cgtggagtgg gagtccaacg gccagcctga gaacaactac   1620

aagaccaccc ctcctgtgct ggactccgac ggctccttct tcctgtactc ccgcctgacc   1680
gtggacaagt cccgctggca ggagggcaac gtgttctcct gctccgtgat gcacgaggcc   1740
ctgcacaacc actacaccca gaagtccctg tccctgtccc tgggcaagta agaattc      1797
<210>  87
<211>  592
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.7ĵڶǻBY31.7H
<400>  87
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          
Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              
Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  
Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  
Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      
Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         
Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             
Pro Thr Pro Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 
Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala 
                165                 170                 175     
Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala 
            180                 185                 190         
Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser 
        195                 200                 205             
Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 
Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala 
225                 230                 235                 240 
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly 
                245                 250                 255     
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            260                 265                 270         
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        275                 280                 285             
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    290                 295                 300                 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
305                 310                 315                 320 
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
                325                 330                 335     
Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
            340                 345                 350         
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
        355                 360                 365             
Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
    370                 375                 380                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
385                 390                 395                 400 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
                405                 410                 415     
Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            420                 425                 430         
Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
        435                 440                 445             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    450                 455                 460                 
Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
465                 470                 475                 480 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                485                 490                 495     
Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            500                 505                 510         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        515                 520                 525             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    530                 535                 540                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
545                 550                 555                 560 
Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                565                 570                 575     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            580                 585                 590         
<210>  88
<211>  1797
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.14ĵһǻPD-1CD80-FcںC˵BY31.14L

<400>  88
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgtcatcca tgtgaccaaa gaggtcaaag aagtcgcaac tctgtcttgc    120
ggacacaacg tctccgtcga agaactcgcc cagactagaa tatattggca gaaggaaaag    180
aagatggtgc tcaccatgat gtccggcgat atgaacattt ggcctgagta caagaaccgg    240
acaatcttcg atattactaa taacctgagt atcgtgattc tcgctctgcg ccctagcgac    300
gagggcacat acgagtgtgt ggtgctgaag tacgagaagg atgcattcaa gcgggagcac    360
ctcgcagagg tgacactctc cgtgaaggcc gacttcccaa ccccatctga caagcgcgtg    420
gagtccaagt acggccctcc ttgccctcct tgccctgccc ctgagttcct gggcggccct    480
tccgtgttcc tgttccctcc taagcctaag gacaccctga tgatctcccg cacccctgag    540
gtgacctgcg tggtggtgga cgtgtcccag gaggaccctg aggtgcagtt caactggtac    600
gtggacggcg tggaggtgca caacgccaag accaagcctc gcgaggagca gttcaactcc    660
acctaccgcg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    720
tacaagtgca aggtgtccaa caagggcctg ccttcctcca tcgagaagac catctccaag    780
gccaagggcc agcctcgcga gcctcaggtg tacaccctgc ctccttccca ggaggagatg    840
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctacccttc cgacatcgcc    900
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg    960
gactccgacg gctccttctt cctgtactcc cgcctgaccg tggacaagtc ccgctggcag   1020
gagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1080
aagtccctgt ccctgtccct gggcggcgga ggatctggcg gcggaggcag tggaggcggc   1140
ggaagtgaga ttgtgctgac acagtccccc gctactctga gcctgagccc tggcgagagg   1200
gctacactgt cttgcagagc ttctcagtcc gtgtcttctt acctcgcttg gtatcagcag   1260
aagcccggcc aggctccaag actgctgatc tatgacgctt ctaaccgcgc tacaggcatt   1320
cctgctaggt tcagcggcag cggctctggc accgacttca cactcacaat tagctctctt   1380
gaacctgagg acttcgccgt gtactactgc cagcagtcta gcaactggcc tagaacattc   1440
ggccagggca ctaaggtgga gattaagaga accgtggccg cccccagcgt gttcatcttc   1500
cctcccagcg acgagcagct gaagtctggc accgccagcg tggtgtgcct gctgaacaac   1560
ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaac   1620
agccaggaga gcgtgaccga gcaggactcc aaggacagca cctacagcct gagcagcacc   1680
ctgaccctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga ggtgacccac   1740
cagggactgt ctagccccgt gaccaagagc ttcaaccggg gcgagtgcta agaattc      1797
<210>  89
<211>  592
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.14ĵһǻPD-1CD80-FcںC˵BY31.14L

<400>  89
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          
Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              
Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  
Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  
Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      
Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         
Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             
Pro Thr Pro Ser Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    130                 135                 140                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            180                 185                 190         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 
        355                 360                 365             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    370                 375                 380                 
Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
385                 390                 395                 400 
Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln 
                405                 410                 415     
Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg 
            420                 425                 430         
Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        435                 440                 445             
Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    450                 455                 460                 
Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr 
465                 470                 475                 480 
Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
                485                 490                 495     
Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
            500                 505                 510         
Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
        515                 520                 525             
Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
    530                 535                 540                 
Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
545                 550                 555                 560 
Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
                565                 570                 575     
Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            580                 585                 590         
<210>  90
<211>  720
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.14ĵڶǻPD-1FabƬεɱCH1ṹ򣬼BY31.14H 
ںϵBY31.14һǻеPD-1ͨӣ
<400>  90
tctagagcca ccatggagac cgacaccctg ctgctgtggg tgctgctcct gtgggtgcct     60
ggctccacag gccaggtgca gctcgtggag tccggcggcg gcgtggtgca gcccggcaga    120
tccctcagac tggactgcaa ggcatccggc attacattct ctaactctgg aatgcactgg    180
gtgagacagg ctcctggcaa gggcctggaa tgggtggccg tgatttggta cgacggctct    240
aagagatact acgctgactc cgtgaagggc cggttcacaa ttagcagaga caactccaag    300
aacactctgt tcctccagat gaacagcctg agagccgagg acaccgctgt gtactactgc    360
gccaccaacg acgactactg gggccagggc accctcgtga cagtgtcttc cgcctccacc    420
aagggccctt ccgtgttccc tctggcccct tgctcccgct ccacctccga gtccaccgcc    480
gccctgggct gcctggtgaa ggactacttc cctgagcctg tgaccgtgtc ctggaactcc    540
ggcgccctga cctccggcgt gcacaccttc cctgccgtgc tgcagtcctc cggcctgtac    600
tccctgtcct ccgtggtgac cgtgccttcc tcctccctgg gcaccaagac ctacacctgc    660
aacgtggacc acaagccttc caacaccaag gtggacaagc gcgtggagtc ctaagtcgac    720
<210>  91
<211>  233
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.14ĵڶǻBY31.14H
<400>  91
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
            20                  25                  30          
Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr 
        35                  40                  45              
Phe Ser Asn Ser Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  

Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr 
65                  70                  75                  80  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      
Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 
Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             
Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 
Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230             
<210>  92
<211>  724
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.15ĵһǻBY31.15LPD-1
<400>  92
tctagagcca ccaatggaga ccgacaccct gctgctgtgg gtgctgctcc tgtgggtgcc     60
tggctccaca ggcgagattg tgctgacaca gtcccccgct actctgagcc tgagccctgg    120
cgagagggct acactgtctt gcagagcttc tcagtccgtg tcttcttacc tcgcttggta    180
tcagcagaag cccggccagg ctccaagact gctgatctat gacgcttcta accgcgctac    240
aggcattcct gctaggttca gcggcagcgg ctctggcacc gacttcacac tcacaattag    300
ctctcttgaa cctgaggact tcgccgtgta ctactgccag cagtctagca actggcctag    360
aacattcggc cagggcacta aggtggagat taagagaacc gtggccgccc ccagcgtgtt    420
catcttccct cccagcgacg agcagctgaa gtctggcacc gccagcgtgg tgtgcctgct    480
gaacaacttc tacccccgcg aggccaaggt gcagtggaag gtggacaacg ccctgcagag    540
cggcaacagc caggagagcg tgaccgagca ggactccaag gacagcacct acagcctgag    600
cagcaccctg accctgagca aggccgacta cgagaagcac aaggtgtacg cctgcgaggt    660
gacccaccag ggactgtcta gccccgtgac caagagcttc aaccggggcg agtgctaagt    720
cgac                                                                 724
<210>  93
<211>  234
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.15ĵһǻBY31.15L
<400>  93
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          
Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser 
            100                 105                 110         
Asn Trp Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 
<210>  94
<211>  1784
<212>  DNA
<213>  ˹
<220>  
<223>  ںϵBY31.15ĵڶǻBY31.15HCD80-FcںCPD-1FabƬε
CH1ṹ
<400>  94
ctcgaggcca ccatggagac cgacacactc ctcctgtggg tgctgctgct gtgggtgcct     60
ggctccactg gcgtcatcca tgtgaccaaa gaggtcaaag aagtcgcaac tctgtcttgc    120
ggacacaacg tctccgtcga agaactcgcc cagactagaa tatattggca gaaggaaaag    180
aagatggtgc tcaccatgat gtccggcgat atgaacattt ggcctgagta caagaaccgg    240
acaatcttcg atattactaa taacctgagt atcgtgattc tcgctctgcg ccctagcgac    300
gagggcacat acgagtgtgt ggtgctgaag tacgagaagg atgcattcaa gcgggagcac    360
ctcgcagagg tgacactctc cgtgaaggcc gacttcccaa ccccatctga caagcgcgtg    420
gagtccaagt acggccctcc ttgccctcct tgccctgccc ctgagttcct gggcggccct    480
tccgtgttcc tgttccctcc taagcctaag gacaccctga tgatctcccg cacccctgag    540
gtgacctgcg tggtggtgga cgtgtcccag gaggaccctg aggtgcagtt caactggtac    600
gtggacggcg tggaggtgca caacgccaag accaagcctc gcgaggagca gttcaactcc    660
acctaccgcg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    720
tacaagtgca aggtgtccaa caagggcctg ccttcctcca tcgagaagac catctccaag    780
gccaagggcc agcctcgcga gcctcaggtg tacaccctgc ctccttccca ggaggagatg    840
accaagaacc aggtgtccct gacctgcctg gtgaagggct tctacccttc cgacatcgcc    900
gtggagtggg agtccaacgg ccagcctgag aacaactaca agaccacccc tcctgtgctg    960
gactccgacg gctccttctt cctgtactcc cgcctgaccg tggacaagtc ccgctggcag   1020
gagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1080
aagtccctgt ccctgtccct gggcggcgga ggatctggcg gcggaggcag tggaggcggc   1140
ggaagtcagg tgcagctcgt ggagtccggc ggcggcgtgg tgcagcccgg cagatccctc   1200
agactggact gcaaggcatc cggcattaca ttctctaact ctggaatgca ctgggtgaga   1260
caggctcctg gcaagggcct ggaatgggtg gccgtgattt ggtacgacgg ctctaagaga   1320
tactacgctg actccgtgaa gggccggttc acaattagca gagacaactc caagaacact   1380
ctgttcctcc agatgaacag cctgagagcc gaggacaccg ctgtgtacta ctgcgccacc   1440
aacgacgact actggggcca gggcaccctc gtgacagtgt cttccgcctc caccaagggc   1500
ccttccgtgt tccctctggc cccttgctcc cgctccacct ccgagtccac cgccgccctg   1560
ggctgcctgg tgaaggacta cttccctgag cctgtgaccg tgtcctggaa ctccggcgcc   1620
ctgacctccg gcgtgcacac cttccctgcc gtgctgcagt cctccggcct gtactccctg   1680
tcctccgtgg tgaccgtgcc ttcctcctcc ctgggcacca agacctacac ctgcaacgtg   1740
gaccacaagc cttccaacac caaggtggac aagcgcgtgg agtc                    1784
<210>  95
<211>  591
<212>  PRT
<213>  ˹
<220>  
<223>  ںϵBY31.15ĵڶǻBY31.15HںϵBY31.15ڶǻеPD-1FabƬε
ɱCH1ṹںϵBY31.15һǻͨӣ
<400>  95
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala 
            20                  25                  30          
Thr Leu Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr 
        35                  40                  45              
Arg Ile Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser 
    50                  55                  60                  
Gly Asp Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp 
65                  70                  75                  80  
Ile Thr Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp 
                85                  90                  95      
Glu Gly Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe 
            100                 105                 110         
Lys Arg Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe 
        115                 120                 125             
Pro Thr Pro Ser Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    130                 135                 140                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
145                 150                 155                 160 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            180                 185                 190         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Ser 
        355                 360                 365             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    370                 375                 380                 
Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Asp Cys 
385                 390                 395                 400 
Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly Met His Trp Val Arg 
                405                 410                 415     
Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp 
            420                 425                 430         
Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             
Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu 
    450                 455                 460                 
Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asn Asp Asp Tyr 
465                 470                 475                 480 
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
                485                 490                 495     
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
            500                 505                 510         
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
        515                 520                 525             
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
    530                 535                 540                 
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
545                 550                 555                 560 
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
                565                 570                 575     
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
            580                 585                 590     



