                         SEQUENCE LISTING

<110>  City of Hope
       Chen, Wenyong
       Wang, Zhiqiang
 
<120>  Composition and Method for Activating Latent Human 
       Immunodeficiency Virus (HIV)

<130>  048440-682001WO

<150>  62/575,307
<151>  2017-10-20

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  1
ctttccgctg gggactttcc a                                                 21


<210>  2
<211>  343
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
aatgaaggag agaacaacag cttgttacac cctatgagcc agcatgggat ggaggacccg       60

gagggagaag tattagtgtg gaagtttgac agcctcctag catttcgtca catggcccga      120

gagctgcatc cggagtacta caaagactgc tgacatcgag ctttctacaa gggactttcc      180

gctggggact ttccagggag gtgtggcctg ggcgggactg gggagtggcg agccctcaga      240

tgctacatat aagcagctgc tttttgcctg tactgggtct ctctggttag accagatctg      300

agcctgggag ctctctggct aactagggaa cccactgctt aag                        343


<210>  3
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
ctcgaacctg gggagaaacc ctacaagtgc cccgaatgcg ggaaaagctt ctcacgcaag       60

gacaatctca agaatcacca gcggacgcac accggagaga agccctacaa gtgccccgaa      120

tgcggaaaat cattctcaca acgcgcccac ttggaacgcc accagagaac acacacaggg      180

gagaagccat acaagtgccc tgaatgcggc aagtctttca gtgaaaggtc ccatctgcga      240

gagcaccagc gaacacatac tggcgagaag ccgtacaagt gtcccgagtg cggcaagagt      300

tttagttcca aaaaacacct ggccgaacat cagcggactc acacagggga gaagccctat      360

aaatgccccg agtgcggcaa gagctttagc gatcccgggg ccctcgtccg acatcagagg      420

acccacacag gggagaaacc ttacaagtgt cctgaatgcg gcaaatcttt cagccagaga      480

gcaaacctgc gagctcacca gagaacccat actggcgaaa agccttataa atgccctgaa      540

tgcgggaaga gtttcagccg ctctgaccac ctgactactc accagcggac acacactggg      600

aagaaaacta gcagcgctgc tgaccccaag aagaagagga aggtg                      645


<210>  4
<211>  1659
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
tcgccaggga tccgtcgact tgacgcgttg atatcaacaa gtttgtacaa aaaagcaggc       60

tacaaagagg ccagcggttc cggacgggct gacgcattgg acgattttga tctggatatg      120

ctgggaagtg acgccctcga tgattttgac cttgacatgc ttggttcgga tgcccttgat      180

gactttgacc tcgacatgct cggcagtgac gcccttgatg atttcgacct ggacatgctg      240

attaactcta gaagttccgg atctccgaaa aagaaacgca aagttggtag ccagtacctg      300

cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta cgagacattc      360

aagagcatca tgaagaagtc ccccttcagc ggccccaccg accctagacc tccacctaga      420

agaatcgccg tgcccagcag atccagcgcc agcgtgccaa aacctgcccc ccagccttac      480

cccttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat ggtgttcccc      540

agcggccaga tctctcaggc ctctgctctg gctccagccc ctcctcaggt gctgcctcag      600

gctcctgctc ctgcaccagc tccagccatg gtgtctgcac tggctcaggc accagcaccc      660

gtgcctgtgc tggctcctgg acctccacag gctgtggctc caccagcccc taaacctaca      720

caggccggcg agggcacact gtctgaagct ctgctgcagc tgcagttcga cgacgaggat      780

ctgggagccc tgctgggaaa cagcaccgat cctgccgtgt tcaccgacct ggccagcgtg      840

gacaacagcg agttccagca gctgctgaac cagggcatcc ctgtggcccc tcacaccacc      900

gagcccatgc tgatggaata ccccgaggcc atcacccggc tcgtgacagg cgctcagagg      960

cctcctgatc cagctcctgc ccctctggga gcaccaggcc tgcctaatgg actgctgtct     1020

ggcgacgagg acttcagctc tatcgccgat atggatttct cagccttgct gggctctggc     1080

agcggcagcc gggattccag ggaagggatg tttttgccga agcctgaggc cggctccgct     1140

attagtgacg tgtttgaggg ccgcgaggtg tgccagccaa aacgaatccg gccatttcat     1200

cctccaggaa gtccatgggc caaccgccca ctccccgcca gcctcgcacc aacaccaacc     1260

ggtccagtac atgagccagt cgggtcactg accccggcac cagtccctca gccactggat     1320

ccagcgcccg cagtgactcc cgaggccagt cacctgttgg aggatcccga tgaagagacg     1380

agccaggctg tcaaagccct tcgggagatg gccgatactg tgattcccca gaaggaagag     1440

gctgcaatct gtggccaaat ggacctttcc catccgcccc caaggggcca tctggatgag     1500

ctgacaacca cacttgagtc catgaccgag gatctgaacc tggactcacc cctgaccccg     1560

gaattgaacg agattctgga taccttcctg aacgacgagt gcctcttgca tgccatgcat     1620

atcagcacag gactgtccat cttcgacaca tctctgttt                            1659


<210>  5
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
ggccgtaaaa aacgtcgtca gcgccgtcgc gtcgacctt                              39


<210>  6
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
aagcgacctg ccgccacaaa gaaggctgga caggctaaga agaagaaa                    48


<210>  7
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
gagcagaagc tgatctcaga ggaggacctg ctt                                    33


<210>  8
<211>  2385
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
gagcagaagc tgatctcaga ggaggacctg cttaagcgac ctgccgccac aaagaaggct       60

ggacaggcta agaagaagaa actcgaacct ggggagaaac cctacaagtg ccccgaatgc      120

gggaaaagct tctcacgcaa ggacaatctc aagaatcacc agcggacgca caccggagag      180

aagccctaca agtgccccga atgcggaaaa tcattctcac aacgcgccca cttggaacgc      240

caccagagaa cacacacagg ggagaagcca tacaagtgcc ctgaatgcgg caagtctttc      300

agtgaaaggt cccatctgcg agagcaccag cgaacacata ctggcgagaa gccgtacaag      360

tgtcccgagt gcggcaagag ttttagttcc aaaaaacacc tggccgaaca tcagcggact      420

cacacagggg agaagcccta taaatgcccc gagtgcggca agagctttag cgatcccggg      480

gccctcgtcc gacatcagag gacccacaca ggggagaaac cttacaagtg tcctgaatgc      540

ggcaaatctt tcagccagag agcaaacctg cgagctcacc agagaaccca tactggcgaa      600

aagccttata aatgccctga atgcgggaag agtttcagcc gctctgacca cctgactact      660

caccagcgga cacacactgg gaagaaaact agcagcgctg ctgaccccaa gaagaagagg      720

aaggtgtcgc cagggatccg tcgacttgac gcgttgatat caacaagttt gtacaaaaaa      780

gcaggctaca aagaggccag cggttccgga cgggctgacg cattggacga ttttgatctg      840

gatatgctgg gaagtgacgc cctcgatgat tttgaccttg acatgcttgg ttcggatgcc      900

cttgatgact ttgacctcga catgctcggc agtgacgccc ttgatgattt cgacctggac      960

atgctgatta actctagaag ttccggatct ccgaaaaaga aacgcaaagt tggtagccag     1020

tacctgcccg acaccgacga ccggcaccgg atcgaggaaa agcggaagcg gacctacgag     1080

acattcaaga gcatcatgaa gaagtccccc ttcagcggcc ccaccgaccc tagacctcca     1140

cctagaagaa tcgccgtgcc cagcagatcc agcgccagcg tgccaaaacc tgccccccag     1200

ccttacccct tcaccagcag cctgagcacc atcaactacg acgagttccc taccatggtg     1260

ttccccagcg gccagatctc tcaggcctct gctctggctc cagcccctcc tcaggtgctg     1320

cctcaggctc ctgctcctgc accagctcca gccatggtgt ctgcactggc tcaggcacca     1380

gcacccgtgc ctgtgctggc tcctggacct ccacaggctg tggctccacc agcccctaaa     1440

cctacacagg ccggcgaggg cacactgtct gaagctctgc tgcagctgca gttcgacgac     1500

gaggatctgg gagccctgct gggaaacagc accgatcctg ccgtgttcac cgacctggcc     1560

agcgtggaca acagcgagtt ccagcagctg ctgaaccagg gcatccctgt ggcccctcac     1620

accaccgagc ccatgctgat ggaatacccc gaggccatca cccggctcgt gacaggcgct     1680

cagaggcctc ctgatccagc tcctgcccct ctgggagcac caggcctgcc taatggactg     1740

ctgtctggcg acgaggactt cagctctatc gccgatatgg atttctcagc cttgctgggc     1800

tctggcagcg gcagccggga ttccagggaa gggatgtttt tgccgaagcc tgaggccggc     1860

tccgctatta gtgacgtgtt tgagggccgc gaggtgtgcc agccaaaacg aatccggcca     1920

tttcatcctc caggaagtcc atgggccaac cgcccactcc ccgccagcct cgcaccaaca     1980

ccaaccggtc cagtacatga gccagtcggg tcactgaccc cggcaccagt ccctcagcca     2040

ctggatccag cgcccgcagt gactcccgag gccagtcacc tgttggagga tcccgatgaa     2100

gagacgagcc aggctgtcaa agcccttcgg gagatggccg atactgtgat tccccagaag     2160

gaagaggctg caatctgtgg ccaaatggac ctttcccatc cgcccccaag gggccatctg     2220

gatgagctga caaccacact tgagtccatg accgaggatc tgaacctgga ctcacccctg     2280

accccggaat tgaacgagat tctggatacc ttcctgaacg acgagtgcct cttgcatgcc     2340

atgcatatca gcacaggact gtccatcttc gacacatctc tgttt                     2385


<210>  9
<211>  2424
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
ggccgtaaaa aacgtcgtca gcgccgtcgc gtcgaccttg agcagaagct gatctcagag       60

gaggacctgc ttaagcgacc tgccgccaca aagaaggctg gacaggctaa gaagaagaaa      120

ctcgaacctg gggagaaacc ctacaagtgc cccgaatgcg ggaaaagctt ctcacgcaag      180

gacaatctca agaatcacca gcggacgcac accggagaga agccctacaa gtgccccgaa      240

tgcggaaaat cattctcaca acgcgcccac ttggaacgcc accagagaac acacacaggg      300

gagaagccat acaagtgccc tgaatgcggc aagtctttca gtgaaaggtc ccatctgcga      360

gagcaccagc gaacacatac tggcgagaag ccgtacaagt gtcccgagtg cggcaagagt      420

tttagttcca aaaaacacct ggccgaacat cagcggactc acacagggga gaagccctat      480

aaatgccccg agtgcggcaa gagctttagc gatcccgggg ccctcgtccg acatcagagg      540

acccacacag gggagaaacc ttacaagtgt cctgaatgcg gcaaatcttt cagccagaga      600

gcaaacctgc gagctcacca gagaacccat actggcgaaa agccttataa atgccctgaa      660

tgcgggaaga gtttcagccg ctctgaccac ctgactactc accagcggac acacactggg      720

aagaaaacta gcagcgctgc tgaccccaag aagaagagga aggtgtcgcc agggatccgt      780

cgacttgacg cgttgatatc aacaagtttg tacaaaaaag caggctacaa agaggccagc      840

ggttccggac gggctgacgc attggacgat tttgatctgg atatgctggg aagtgacgcc      900

ctcgatgatt ttgaccttga catgcttggt tcggatgccc ttgatgactt tgacctcgac      960

atgctcggca gtgacgccct tgatgatttc gacctggaca tgctgattaa ctctagaagt     1020

tccggatctc cgaaaaagaa acgcaaagtt ggtagccagt acctgcccga caccgacgac     1080

cggcaccgga tcgaggaaaa gcggaagcgg acctacgaga cattcaagag catcatgaag     1140

aagtccccct tcagcggccc caccgaccct agacctccac ctagaagaat cgccgtgccc     1200

agcagatcca gcgccagcgt gccaaaacct gccccccagc cttacccctt caccagcagc     1260

ctgagcacca tcaactacga cgagttccct accatggtgt tccccagcgg ccagatctct     1320

caggcctctg ctctggctcc agcccctcct caggtgctgc ctcaggctcc tgctcctgca     1380

ccagctccag ccatggtgtc tgcactggct caggcaccag cacccgtgcc tgtgctggct     1440

cctggacctc cacaggctgt ggctccacca gcccctaaac ctacacaggc cggcgagggc     1500

acactgtctg aagctctgct gcagctgcag ttcgacgacg aggatctggg agccctgctg     1560

ggaaacagca ccgatcctgc cgtgttcacc gacctggcca gcgtggacaa cagcgagttc     1620

cagcagctgc tgaaccaggg catccctgtg gcccctcaca ccaccgagcc catgctgatg     1680

gaataccccg aggccatcac ccggctcgtg acaggcgctc agaggcctcc tgatccagct     1740

cctgcccctc tgggagcacc aggcctgcct aatggactgc tgtctggcga cgaggacttc     1800

agctctatcg ccgatatgga tttctcagcc ttgctgggct ctggcagcgg cagccgggat     1860

tccagggaag ggatgttttt gccgaagcct gaggccggct ccgctattag tgacgtgttt     1920

gagggccgcg aggtgtgcca gccaaaacga atccggccat ttcatcctcc aggaagtcca     1980

tgggccaacc gcccactccc cgccagcctc gcaccaacac caaccggtcc agtacatgag     2040

ccagtcgggt cactgacccc ggcaccagtc cctcagccac tggatccagc gcccgcagtg     2100

actcccgagg ccagtcacct gttggaggat cccgatgaag agacgagcca ggctgtcaaa     2160

gcccttcggg agatggccga tactgtgatt ccccagaagg aagaggctgc aatctgtggc     2220

caaatggacc tttcccatcc gcccccaagg ggccatctgg atgagctgac aaccacactt     2280

gagtccatga ccgaggatct gaacctggac tcacccctga ccccggaatt gaacgagatt     2340

ctggatacct tcctgaacga cgagtgcctc ttgcatgcca tgcatatcag cacaggactg     2400

tccatcttcg acacatctct gttt                                            2424


<210>  10
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
tttccgctgg ggactttcca g                                                 21


<210>  11
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
actcaaggca agctttattg aggc                                              24


<210>  12
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
1               5                   10                  15      


Phe Ser Arg Lys Asp Asn Leu Lys Asn His Gln Arg Thr His Thr Gly 
            20                  25                  30          


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg 
        35                  40                  45              


Ala His Leu Glu Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
    50                  55                  60                  


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Glu Arg Ser His Leu Arg 
65                  70                  75                  80  


Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
                85                  90                  95      


Cys Gly Lys Ser Phe Ser Ser Lys Lys His Leu Ala Glu His Gln Arg 
            100                 105                 110         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
        115                 120                 125             


Phe Ser Asp Pro Gly Ala Leu Val Arg His Gln Arg Thr His Thr Gly 
    130                 135                 140                 


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg 
145                 150                 155                 160 


Ala Asn Leu Arg Ala His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
                165                 170                 175     


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp His Leu Thr 
            180                 185                 190         


Thr His Gln Arg Thr His Thr Gly Lys Lys Thr Ser Ser Ala Ala Asp 
        195                 200                 205             


Pro Lys Lys Lys Arg Lys Val 
    210                 215 


<210>  13
<211>  553
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Ser Pro Gly Ile Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr 
1               5                   10                  15      


Lys Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala 
            20                  25                  30          


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
        35                  40                  45              


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
    50                  55                  60                  


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
65                  70                  75                  80  


Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly 
                85                  90                  95      


Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys 
            100                 105                 110         


Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro 
        115                 120                 125             


Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val 
    130                 135                 140                 


Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr 
145                 150                 155                 160 


Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr 
                165                 170                 175     


Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro 
            180                 185                 190         


Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro 
        195                 200                 205             


Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu 
    210                 215                 220                 


Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr 
225                 230                 235                 240 


Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe 
                245                 250                 255     


Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala 
            260                 265                 270         


Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu 
        275                 280                 285             


Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu 
    290                 295                 300                 


Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg 
305                 310                 315                 320 


Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn 
                325                 330                 335     


Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp 
            340                 345                 350         


Phe Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu 
        355                 360                 365             


Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val 
    370                 375                 380                 


Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His 
385                 390                 395                 400 


Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala 
                405                 410                 415     


Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro 
            420                 425                 430         


Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu 
        435                 440                 445             


Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val 
    450                 455                 460                 


Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu 
465                 470                 475                 480 


Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly 
                485                 490                 495     


His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu 
            500                 505                 510         


Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr 
        515                 520                 525             


Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly 
    530                 535                 540                 


Leu Ser Ile Phe Asp Thr Ser Leu Phe 
545                 550             


<210>  14
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Val Asp Leu 
1               5                   10              


<210>  15
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  16
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu 
1               5                   10      


<210>  17
<211>  795
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Leu Lys Arg Pro Ala Ala 
1               5                   10                  15      


Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu Pro Gly Glu 
            20                  25                  30          


Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Lys Asp 
        35                  40                  45              


Asn Leu Lys Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys 
    50                  55                  60                  


Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Ala His Leu Glu Arg 
65                  70                  75                  80  


His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys 
                85                  90                  95      


Gly Lys Ser Phe Ser Glu Arg Ser His Leu Arg Glu His Gln Arg Thr 
            100                 105                 110         


His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe 
        115                 120                 125             


Ser Ser Lys Lys His Leu Ala Glu His Gln Arg Thr His Thr Gly Glu 
    130                 135                 140                 


Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Pro Gly 
145                 150                 155                 160 


Ala Leu Val Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys 
                165                 170                 175     


Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Ala Asn Leu Arg Ala 
            180                 185                 190         


His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys 
        195                 200                 205             


Gly Lys Ser Phe Ser Arg Ser Asp His Leu Thr Thr His Gln Arg Thr 
    210                 215                 220                 


His Thr Gly Lys Lys Thr Ser Ser Ala Ala Asp Pro Lys Lys Lys Arg 
225                 230                 235                 240 


Lys Val Ser Pro Gly Ile Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser 
                245                 250                 255     


Leu Tyr Lys Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala 
            260                 265                 270         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
        275                 280                 285             


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
    290                 295                 300                 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
305                 310                 315                 320 


Met Leu Ile Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys 
                325                 330                 335     


Val Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu 
            340                 345                 350         


Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys 
        355                 360                 365             


Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile 
    370                 375                 380                 


Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln 
385                 390                 395                 400 


Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe 
                405                 410                 415     


Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu 
            420                 425                 430         


Ala Pro Ala Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro 
        435                 440                 445             


Ala Pro Ala Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro 
    450                 455                 460                 


Val Leu Ala Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys 
465                 470                 475                 480 


Pro Thr Gln Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu 
                485                 490                 495     


Gln Phe Asp Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp 
            500                 505                 510         


Pro Ala Val Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln 
        515                 520                 525             


Gln Leu Leu Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro 
    530                 535                 540                 


Met Leu Met Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala 
545                 550                 555                 560 


Gln Arg Pro Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu 
                565                 570                 575     


Pro Asn Gly Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp 
            580                 585                 590         


Met Asp Phe Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser 
        595                 600                 605             


Arg Glu Gly Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser 
    610                 615                 620                 


Asp Val Phe Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro 
625                 630                 635                 640 


Phe His Pro Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser 
                645                 650                 655     


Leu Ala Pro Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu 
            660                 665                 670         


Thr Pro Ala Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr 
        675                 680                 685             


Pro Glu Ala Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln 
    690                 695                 700                 


Ala Val Lys Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys 
705                 710                 715                 720 


Glu Glu Ala Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro 
                725                 730                 735     


Arg Gly His Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu 
            740                 745                 750         


Asp Leu Asn Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu 
        755                 760                 765             


Asp Thr Phe Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser 
    770                 775                 780                 


Thr Gly Leu Ser Ile Phe Asp Thr Ser Leu Phe 
785                 790                 795 


<210>  18
<211>  808
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Val Asp Leu Glu Gln Lys 
1               5                   10                  15      


Leu Ile Ser Glu Glu Asp Leu Leu Lys Arg Pro Ala Ala Thr Lys Lys 
            20                  25                  30          


Ala Gly Gln Ala Lys Lys Lys Lys Leu Glu Pro Gly Glu Lys Pro Tyr 
        35                  40                  45              


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Arg Lys Asp Asn Leu Lys 
    50                  55                  60                  


Asn His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
65                  70                  75                  80  


Cys Gly Lys Ser Phe Ser Gln Arg Ala His Leu Glu Arg His Gln Arg 
                85                  90                  95      


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
            100                 105                 110         


Phe Ser Glu Arg Ser His Leu Arg Glu His Gln Arg Thr His Thr Gly 
        115                 120                 125             


Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ser Lys 
    130                 135                 140                 


Lys His Leu Ala Glu His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
145                 150                 155                 160 


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Pro Gly Ala Leu Val 
                165                 170                 175     


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
            180                 185                 190         


Cys Gly Lys Ser Phe Ser Gln Arg Ala Asn Leu Arg Ala His Gln Arg 
        195                 200                 205             


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
    210                 215                 220                 


Phe Ser Arg Ser Asp His Leu Thr Thr His Gln Arg Thr His Thr Gly 
225                 230                 235                 240 


Lys Lys Thr Ser Ser Ala Ala Asp Pro Lys Lys Lys Arg Lys Val Ser 
                245                 250                 255     


Pro Gly Ile Arg Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys 
            260                 265                 270         


Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu 
        275                 280                 285             


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
    290                 295                 300                 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
305                 310                 315                 320 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile 
                325                 330                 335     


Asn Ser Arg Ser Ser Gly Ser Pro Lys Lys Lys Arg Lys Val Gly Ser 
            340                 345                 350         


Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg 
        355                 360                 365             


Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe 
    370                 375                 380                 


Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro 
385                 390                 395                 400 


Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro 
                405                 410                 415     


Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met 
            420                 425                 430         


Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala 
        435                 440                 445             


Pro Pro Gln Val Leu Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala 
    450                 455                 460                 


Met Val Ser Ala Leu Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala 
465                 470                 475                 480 


Pro Gly Pro Pro Gln Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln 
                485                 490                 495     


Ala Gly Glu Gly Thr Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp 
            500                 505                 510         


Asp Glu Asp Leu Gly Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val 
        515                 520                 525             


Phe Thr Asp Leu Ala Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu 
    530                 535                 540                 


Asn Gln Gly Ile Pro Val Ala Pro His Thr Thr Glu Pro Met Leu Met 
545                 550                 555                 560 


Glu Tyr Pro Glu Ala Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro 
                565                 570                 575     


Pro Asp Pro Ala Pro Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly 
            580                 585                 590         


Leu Leu Ser Gly Asp Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe 
        595                 600                 605             


Ser Ala Leu Leu Gly Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly 
    610                 615                 620                 


Met Phe Leu Pro Lys Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe 
625                 630                 635                 640 


Glu Gly Arg Glu Val Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro 
                645                 650                 655     


Pro Gly Ser Pro Trp Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro 
            660                 665                 670         


Thr Pro Thr Gly Pro Val His Glu Pro Val Gly Ser Leu Thr Pro Ala 
        675                 680                 685             


Pro Val Pro Gln Pro Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala 
    690                 695                 700                 


Ser His Leu Leu Glu Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys 
705                 710                 715                 720 


Ala Leu Arg Glu Met Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala 
                725                 730                 735     


Ala Ile Cys Gly Gln Met Asp Leu Ser His Pro Pro Pro Arg Gly His 
            740                 745                 750         


Leu Asp Glu Leu Thr Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn 
        755                 760                 765             


Leu Asp Ser Pro Leu Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe 
    770                 775                 780                 


Leu Asn Asp Glu Cys Leu Leu His Ala Met His Ile Ser Thr Gly Leu 
785                 790                 795                 800 


Ser Ile Phe Asp Thr Ser Leu Phe 
                805             


