                         SEQUENCE LISTING

<110>  FRED HUTCHINSON CANCER RESEARCH CENTER
 
<120>  SYSTEMS AND METHODS TO PRODUCE B CELLS GENETICALLY MODIFIED TO 
       EXPRESS SELECTED ANTIBODIES

<130>  F053-0072PCT/18-024-WO-PCT

<150>  62/575,275
<151>  2017-10-20

<150>  62/580,303
<151>  2017-11-01

<150>  62/623,371
<151>  2018-01-29

<160>  366   

<170>  PatentIn version 3.5

<210>  1
<211>  722
<212>  DNA
<213>  Homo sapiens

<400>  1
ctacatggac gtctggggca aagggaccac ggtcaccgtc tcctcaggta agaatggcca       60

ctctagggcc tttgttttct gctactgcct gtggggtttc ctgagcattg caggttggtc      120

ctcggggcat gttccgaggg gacctgggcg gactggccag gaggggatgg gcactggggt      180

gccttgagga tctgggagcc tctgtggatt ttccgatgcc tttggaaaat gggactcagg      240

ttgggtgcgt ctgatggagt aactgagcct gggggcttgg ggagccacat ttggacgaga      300

tgcctgaaca aaccaggggt cttagtgatg gctgaggaat gtgtctcagg agcggtgtct      360

gtaggactgc aagatcgctg cacagcagcg aatcgtgaaa tattttcttt agaattatga      420

ggtgcgctgt gtgtcaacct gcatcttaaa ttctttattg gctggaaaga gaactgtcgg      480

agtgggtgaa tccagccagg agggacgcgt agccccggtc ttgatgagag cagggttggg      540

ggcaggggta gcccagaaac ggtggctgcc gtcctgacag gggcttaggg aggctccagg      600

acctcagtgc cttgaagctg gtttccatga gaaaaggatt gtttatctta ggaggcatgc      660

ttactgttaa aagacaggat atgtttgaag tggcttctga gaaaaatggt taagaaaatt      720

at                                                                     722


<210>  2
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  2
ctcactttag gataagtttt aggtaaaatg tgcatcatta tcctgaatta tttcagttaa       60

gcatgttagt tggtggcata agagaaaact caatcagata gtgctgaaga caggactgtg      120

gagacacctt agaaggacag attctgttcc gaatcaccga tgcggcgtca gcaggactgg      180

cctagcggag gctctgggag ggtggctgcc aggcccggcc tgggctttgg gtctccccgg      240

actacccaga gctgggatgc gtggcttctg ctgccgggcc gactggctgc tcaggcccca      300

gcccttgtta atggacttgg aggaatgatt ccatgccaaa gctttgcaag gctcgcagtg      360

accaggcgcc cgacatggta agagacaggc agccgccgct gctgcatttg cttctcttaa      420

aactttgtat ttgacgtctt atttccacta gaaggggaac tggtcttaat tgcttgatga      480

agagcaggag actcatttat gtgagtcttt tgagtgacca ttgtctgggt cactcccatt      540

taactttccc taaagcccat ttgaaggaga ggtcgcacga gctgctccac aacctctgaa      600

tggggatggc atgggtaatg atgcttgaga acataccaag ccccactggc atcgcccttg      660

tctaagtcat tgactgtagg tcatcatcgc acccttgaaa gtagcccatg ccttccaaag      720

cgatttatgg taaatggcag aattttaagt ggcaaattca gataaaatgc atttcttggt      780

tgtttccaat gatgactgtt atctagaggg aatttaaagg caggggttta ctgcagactc      840

agaagggagg ggatgctccg ggaaggtgga ggctctgagc atctcaatac cctcctcttg      900

gtgcagaaga tatgctgcca cttctagagc aaggggacct gctcattttt atcacagcac      960

aggctcctaa attcttggtc tcattctcaa gatgttttaa tgactttaaa gcagcaaaga     1020

aatattccac ccaggtagtg gagggtggta atgattggta atgctttgga accaaaaccc     1080

aggtggcgct ggggcaggac tgcagggaac tggggtatca agtagaggga gacaaaagat     1140

ggaagccagc ctggctgtgc aggaacccgg caatgagatg gctttagctg agacaagcag     1200

gtctggtggg ctgaccattt ctggccatga caactccatc cagctttcag aaatggactc     1260

agatgggcaa aactgaccta agctgaccta gactaaacaa ggctgaac                  1308


<210>  3
<211>  582
<212>  DNA
<213>  Mus musculus

<400>  3
ggactactgg ggtcaaggaa cctcagtcac cgtctcctca ggtaagaatg gcctctccag       60

gtctttattt ttaacctttg ttatggagtt ttctgagcat tgcagactaa tcttggatat      120

ttgtccctga gggagccggc tgagagaagt tgggaaataa actgtctagg gatctcagag      180

cctttaggac agattatctc cacatctttg aaaaactaag aatctgtgtg atggtgttgg      240

tggagtccct ggatgatggg atagggactt tggaggctca tttgaagaag atgctaaaac      300

aatcctatgg ctggagggat agttggggct gtagttggag attttcagtt tttagaataa      360

aagtattagt tgtggaatat acttcaggac cacctctgtg acagcattta tacagtatcc      420

gatgcatagg gacaaagagt ggagtggggc actttcttta gatttgtgag gaatgttccg      480

cactagattg tttaaaactt catttgttgg aaggagagct gtcttagtga ttgagtcaag      540

ggagaaaggc atctagcctc ggtctcaaaa gggtagttgc tg                         582


<210>  4
<211>  1528
<212>  DNA
<213>  Mus musculus

<400>  4
ttatttcagt tgaacatgct ggttggtggt tgagaggaca ctcagtcagt cagtgacgtg       60

aagggcttct aagccagtcc acatgctctg tgtgaactcc ctctggccct gcttattgtt      120

gaatgggcca aaggtctgag accaggctgc tgctgggtag gcctggactt tgggtctccc      180

acccagacct gggaatgtat ggttgtggct tctgccaccc atccacctgg ctgctcatgg      240

accagccagc ctcggtggct ttgaaggaac aattccacac aaagactctg gacctctccg      300

aaaccaggca ccgcaaatgg taagccagag gcagccacag ctgtggctgc tgctcttaaa      360

gcttgtaaac tgtttctgct taagagggac tgagtcttca gtcattgctt tagggggaga      420

aagagacatt tgtgtgtctt ttgagtaccg ttgtctgggt cactcacatt taactttcct      480

tgaaaaacta gtaaaagaaa aatgttgcct gttaaccaat aatcatagag ctcatggtac      540

tttgaggaaa tcttagaaag cgtgtataca attgtctgga attatttcag ttaagtgtat      600

tagttgaggt actgatgctg tctctacttc agttatacat gtgggtttga attttgaatc      660

tattctggct cttcttaagc agaaaattta gataaaatgg atacctcagt ggtttttaat      720

ggtgggttta atatagaagg aatttaaatt ggaagctaat ttagaatcag taaggaggga      780

cccaggctaa gaaggcaatc ctgggattct ggaagaaaag atgtttttag tttttataga      840

aaacactact acattcttga tctacaactc aatgtggttt aatgaatttg aagttgccag      900

taaatgtact tcctggttgt taaagaatgg tatcaaagga cagtgcttag atccgaggtg      960

agtgtgagag gacaggggct ggggtatgga tacgcagaag gaaggccaca gctgtacaga     1020

attgagaaag aatagagacc tgcagttgag gccagcaggt cggctggact aactctccag     1080

ccacagtaat gacccagaca gagaaagcca gactcataaa gcttgctgag caaaattaag     1140

ggaacaaggt tgagagccct agtaagcgag gctctaaaaa gcacagctga gctgagatgg     1200

gtgggcttct ctgagtgctt ctaaaatgcg ctaaactgag gtgattactc tgaggtaagc     1260

aaagctgggc ttgagccaaa atgaagtaga ctgtaatgaa ctggaatgag ctgggccgct     1320

aagctaaact aggctggctt aaccgagatg agccaaactg gaatgaactt cattaatcta     1380

ggttgaatag agctaaactc tactgcctac actggactgt tctgagctga gatgagctgg     1440

ggtgagctca gctatgctac gctgtgttgg ggtgagctga tctgaaatga gatactctgg     1500

agtagctgag atggggtgag atggggtg                                        1528


<210>  5
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  5
ggtcctcggg gcatgttccg agg                                               23


<210>  6
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  6
gggcatgttc cgaggggacc tgg                                               23


<210>  7
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  7
gcattgcagg ttggtcctcg ggg                                               23


<210>  8
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  8
tcctcggggc atgttccgag ggg                                               23


<210>  9
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  9
ggcatgttcc gaggggacct ggg                                               23


<210>  10
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  10
gtctcaggag cggtgtctgt agg                                               23


<210>  11
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  11
agcattgcag gttggtcctc ggg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  12
cctgggcgga ctggccagga ggg                                               23


<210>  13
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  13
actggggtgc cttgaggatc tgg                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  14
ccccagtgcc catcccctcc tgg                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  15
ctaagacccc tggtttgttc agg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  16
tgtggatttt ccgatgcctt tgg                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  17
aggaccaacc tgcaatgctc agg                                               23


<210>  18
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  18
ctcaggttgg gtgcgtctga tgg                                               23


<210>  19
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  19
ccctcctggc cagtccgccc agg                                               23


<210>  20
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  20
ggccaggagg ggatgggcac tgg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  21
gagatgcctg aacaaaccag ggg                                               23


<210>  22
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  22
aggggtctta gtgatggctg agg                                               23


<210>  23
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  23
atgggcactg gggtgccttg agg                                               23


<210>  24
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  24
ttccgatgcc tttggaaaat ggg                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  25
ctgacgccgc atcggtgatt cgg                                               23


<210>  26
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  26
ttagacaagg gcgatgccag tgg                                               23


<210>  27
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  27
cgtgcgacct ctccttcaaa tgg                                               23


<210>  28
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  28
agcatatctt ctgcaccaag agg                                               23


<210>  29
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  29
atattccacc caggtagtgg agg                                               23


<210>  30
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  30
gtgcgacctc tccttcaaat ggg                                               23


<210>  31
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  31
aggtcccctt gctctagaag tgg                                               23


<210>  32
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  32
ctctagataa cagtcatcat tgg                                               23


<210>  33
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  33
ttgtctaagt cattgactgt agg                                               23


<210>  34
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  34
ccaaagcgat ttatggtaaa tgg                                               23


<210>  35
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  35
tcttttgagt gaccattgtc tgg                                               23


<210>  36
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  36
ccatttacca taaatcgctt tgg                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  37
agggcgatgc cagtggggct tgg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  38
agctaaagcc atctcattgc cgg                                               23


<210>  39
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  39
ccacaacctc tgaatgggga tgg                                               23


<210>  40
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  40
ttaattgctt gatgaagagc agg                                               23


<210>  41
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  41
tagacaaggg cgatgccagt ggg                                               23


<210>  42
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  42
aagctgacct agactaaaca agg                                               23


<210>  43
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  43
gcaggaaccc ggcaatgaga tgg                                               23


<210>  44
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  44
tctgttccga atcaccgatg cgg                                               23


<210>  45
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  45
caactaccct tttgagaccg agg                                               23


<210>  46
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  46
ttatacagta tccgatgcat agg                                               23


<210>  47
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  47
tatacagtat ccgatgcata ggg                                               23


<210>  48
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  48
catctagcct cggtctcaaa agg                                               23


<210>  49
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  49
cactctttgt ccctatgcat cgg                                               23


<210>  50
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  50
atctagcctc ggtctcaaaa ggg                                               23


<210>  51
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  51
aagttttaaa caatctagtg cgg                                               23


<210>  52
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  52
aagatgctaa aacaatccta tgg                                               23


<210>  53
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  53
tgctaaaaca atcctatggc tgg                                               23


<210>  54
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  54
aagtccctat cccatcatcc agg                                               23


<210>  55
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  55
gggagaaagg catctagcct cgg                                               23


<210>  56
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  56
tgagcattgc agactaatct tgg                                               23


<210>  57
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  57
ttagttgtgg aatatacttc agg                                               23


<210>  58
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  58
tggtggagtc cctggatgat ggg                                               23


<210>  59
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  59
gtggagataa tctgtcctaa agg                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  60
agtccctatc ccatcatcca ggg                                               23


<210>  61
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  61
atcttggata tttgtccctg agg                                               23


<210>  62
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  62
gggatagttg gggctgtagt tgg                                               23


<210>  63
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  63
caggtaagaa tggcctctcc agg                                               23


<210>  64
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  64
tctctcagcc ggctccctca ggg                                               23


<210>  65
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  65
ccgaaaccag gcaccgcaaa tgg                                               23


<210>  66
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  66
caccgcaaat ggtaagccag agg                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  67
ggcttaccat ttgcggtgcc tgg                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  68
tgcggtgcct ggtttcggag agg                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  69
cagctatgct acgctgtgtt ggg                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  70
aaggacagtg cttagatccg agg                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  71
tcagtcagtc agtgacgtga agg                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  72
catgctggtt ggtggttgag agg                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  73
tcttttgagt accgttgtct ggg                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  74
tggcccattc aacaataagc agg                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  75
ctgggccgct aagctaaact agg                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  76
gccagcctag tttagcttag cgg                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  77
tgaagtagac tgtaatgaac tgg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  78
gacctgggaa tgtatggttg tgg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  79
ggtatggata cgcagaagga agg                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  80
gttgagagcc ctagtaagcg agg                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  81
gccgctaagc taaactaggc tgg                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  82
tcagctatgc tacgctgtgt tgg                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  83
ttttagagcc tcgcttacta ggg                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  84
ctctatgatt attggttaac agg                                               23


<210>  85
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  85
gtagttgaaa agtggtcttg aaaaatacta aaatgaaggc cactctatca gaatatcaaa       60

gtgtttctcc ttaatcacaa agagaaaacg agttaaccta aaaagattgt gaacacagtc      120

attatgaaaa taatgctctg aggtatcgaa aaagtatttg agattaatta tcacatgaag      180

ggataacaag ctaatttaaa aaactttttg aatacagtca taaactctcc ctaagactgt      240

ttaatttctt aaacatctta ctttaaaaat gaatgcagtt tagaagttga tatgctgttt      300

gcacaaacta gcagttgata agctaagatt ggaaatgaaa ttcagatagt taaaaaaagc      360

cttttcagtt tcggtcagcc tcgccttatt ttagaaacgc aaattgtcca ggtgttgttt      420

tgctcagtag agcactttca gatctgggcc tgggcaaaac cacctcttca caaccagaag      480

tgataaattt accaattgtg tttttttgct tcctaaaata gactctcgcg gtgacctgct      540

tcctgccacc tgctgtgggt gccggagacc cccatgcagc catcttgact ctaattcatc      600

atctgcttcc agcttcgctc aattaattaa aaaaataaac ttgatttatg atggtcaaaa      660

cgcagtcccg catcggggcc gacagcactg tgctagtatt tcttagctga gcttgctttg      720

gcctcaattc cagacacata tcactcatgg gtgttaatca aatgataaga atttcaaata      780

cttggacagt taaaaaaatt aatatacttg aaaatctctc acatttttaa gtca            834


<210>  86
<211>  1002
<212>  DNA
<213>  Mus musculus

<400>  86
agtctagata attgcattca tttaaaaaaa aagtctttct cctaaaatga atactcagaa       60

agtggtcttg aaaaagattt gtgaagccgt tttgaccaga atgtcaaagt cttaatagta      120

aggcaaaaca aacaactaaa aaagatcatg aacaaagtca ctgtaaatgc ttcgggtatt      180

ggaaaagaat tgaatggaga ccaataatca gagggaagaa taatagagta attttaagaa      240

gttttctaaa tatattagaa attaaagaca ctaaagtcct tcaatttctt acataaccta      300

attttgaaaa tgaattctaa atacatttta gaagtcgata aacttaagtt tggggaaact      360

agaactactc aagctaaaat taaaaggttg aactcaataa gttaaaagag gacctctcca      420

gtttcggctg aatcctcaac ttattttaga aatgcaaatt acccaggtgg tgttttgctc      480

agcctggact ttcggtttgg tggggctgga cagagtgttt caaaaccact tcttcaaacc      540

acagctacaa gtttacctag tggttttatt ttcccttccc caaatagcct tgccacatga      600

cctgcttcct gccagctgct gcaggtgttc tggttctgat cggccatctt gactccaact      660

caacattgct caattcattt aaaaatattt gaaacttaat ttattattgt taaaagtcag      720

ttctgaatag gttatgagag agcctcactc ccattcctcg gttaaacttt aagtaatatc      780

agttctacac aaacaagacc tcaaactgat tgacaagaat tttggacatt taaaaaaatg      840

agtacttgaa aaccctctca cattttaaag tcacagtatt taactatttt tcctaggaac      900

caacttaaga gtaaaagcaa catcttctaa tattccatac acatacttct gtgttccttt      960

gaaagctgga cttttgcagg ctccaccaga cctctctaga ca                        1002


<210>  87
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  mouse sgRNA-mIgH_3 from FIG. 25A

<400>  87
uuauacagua uccgaugcau                                                   20


<210>  88
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  human sgRNA-hIgH-6 from FIG. 25A

<400>  88
gcauugcagg uugguccucg                                                   20


<210>  89
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  human sgRNA-hIgH-7 from FIG. 25A

<400>  89
gucucaggag cggugucugu                                                   20


<210>  90
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  90
catcggatac tgtataaatg ctgtcacaga ggtggt                                 36


<210>  91
<211>  36
<212>  DNA
<213>  Mus musculus

<400>  91
catagggaca aagagtggag tggggcactt tcttta                                 36


<210>  92
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  92
gacaccgctc ctgagacaca ttcctcagcc atcact                                 36


<210>  93
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  93
tgtaggactg caagatcgct gcacagcagc gaatcg                                 36


<210>  94
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  94
gggaccaacc tgcaatgctc aggaaacccc acaggca                                37


<210>  95
<211>  37
<212>  DNA
<213>  Homo sapiens

<400>  95
ttcggggcat gttccgaggg gacctgggcg gactggc                                37


<210>  96
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  upstream splicing oligonucleotide for mouse sgRNA-mIgH_3

<400>  96
cttcgagaca tgtacagacc atttagatgt agtatcaaag cctaatatct caatcttaaa       60

atagaatcct aacctgagac actcacttgt ccatcggata ctgtataaat gctgtcacag      120

aggtggt                                                                127


<210>  97
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  downstream splicing oligonucleotide for mouse sgRNA-mIgH_3

<400>  97
cttctcccat tctaaatgca tgttgggggg attctgggcc ttcaggacca catagggaca       60

aagagtggag tggggcactt tcttta                                            86


<210>  98
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  upstream splicing oligonucleotide for human sgRNA-hIgH-7

<400>  98
gtgcacagcg ctcttcccgc tgcagaacaa accccaaccc caggatgcac tcctcactgt       60

gaacccacat tttattggcc taaagattac ggacaccgct cctgagacac attcctcagc      120

catcact                                                                127


<210>  99
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  downstream splicing oligonucleotide for human sgRNA-hIgH-7

<400>  99
gtctggggat agcggggagc caggtgtact gggccaggca agggctttgg tgtaggactg       60

caagatcgct gcacagcagc gaatcg                                            86


<210>  100
<211>  128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  upstream splicing oligonucleotide for human sgRNA-hIgH-6

<400>  100
gtgcacagcg ctcttcccgc tgcagaacaa accccaaccc caggatgcac tcctcactgt       60

gaacccacat tttattggcc taaagattac ggggaccaac ctgcaatgct caggaaaccc      120

cacaggca                                                               128


<210>  101
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  downstream splicing oligonucleotide for human sgRNA-hIgH-6

<400>  101
gtctggggat agcggggagc caggtgtact gggccaggca agggctttgg ttcggggcat       60

gttccgaggg gacctgggcg gactggc                                           87


<210>  102
<211>  2531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human anti-RSV-emAb AAV

<400>  102
tgtgacgccc ggagacagaa ggtctctggg tggctgggtt tttgtggggt gaggatggac       60

attctgccat tgtgattact actactacta ctacatggac gtctggggca aagggaccac      120

ggtcaccgtc tcctcaggta agaatggcca ctctagggcc tttgttttct gctactgcct      180

gtggggtttc ctgagcattg caggttggtc ctcggggcat gttccgaggg gacctgggcg      240

gactggccag gaggggatgg gcactggggt gccttgagga tctgggagcc tctgtggatt      300

ttccgatgcc tttggaaaat gggactcagg ttgggtgcgt ctgatggagt aactgagcct      360

gggggcttgg ggagccacat ttggacgaga tgcctgaaca aaccaggggt cttagtgatg      420

gctgaggaat gtgtctcagg agcggtgtct gatcgtaatc tttaggccaa taaaatgtgg      480

gttcacagtg aggagtgcat cctggggttg gggtttgttc tgcagcggga agagcgctgt      540

gcacagaaag cttagaaatg gggcaagaga tgcttttcct caggcaggat ttagggcttg      600

gtctctcagc atcccacact tgtacagctg atgtggcatc tgtgttttct ttctcatcct      660

agatcaggct ttgagctgtg aaataccctg cctcatgcat atgcaaataa cctgaggtct      720

tctgagataa atatagatat attggtgccc tgaggtttaa acgccgccac catggctacc      780

ggcagcagaa caagcctgct gctcgctttt ggactgctct gtctcccctg gttgcaagaa      840

ggcagcgccg acatccagat gacacagagc cctagcacac tgtctgccag cgtgggcgac      900

agagtgacca tcacatgcaa gtgccagctg agcgtgggct acatgcactg gtatcagcaa      960

aagcccggca aggcccctaa gctgctgatc tacgatacct ccaagctggc ctctggcgtg     1020

ccctccagat tttctggcag cggcagcgga accgagttca ccctgaccat ctcaagcctg     1080

cagcctgacg acttcgctac gtactactgc ttccaaggca gcggctaccc cttcacattt     1140

ggcggcggaa caaagctgga aatcaagcgg actgtggccg ctcctagcgt gttcatcttt     1200

ccacctagcg acgagcagct gaagtctggc actgcctctg tcgtgtgcct gctgaacaac     1260

ttctaccctc gagaggccaa ggtgcagtgg aaagtggaca atgccctgca gagcggcaac     1320

agccaagagt ctgtgaccga gcaggactcc aaggattcca cctacagcct gtctagcacc     1380

ctgactctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacacac     1440

cagggactga gcagccctgt gaccaagagc ttcaatcggg gcgagtgcgg aggaagtagt     1500

ggcagcggga gtgggtccaa ttggagtcat cctcaatttg agaaaggagg gggagggtcc     1560

aattggtctc atccgcagtt tgagaagggc ggcggcggct ccaattggtc ccatccccag     1620

tttgaaaaag gctctggtgg aggtggtagt gctggtgggc aagtgaccct gagagagtct     1680

ggacctgctc tggtcaagcc cacacagacc ctgacactga cctgcacctt cagcggcttt     1740

agcctgagca caagcggcat gagcgtcggc tggattagac agcctcctgg caaagccctg     1800

gaatggctgg ccgacatttg gtgggacgac aagaaggact acaaccccag cctgaagtcc     1860

cggctgacca tcagcaagga caccagcaag aaccaggtgg tgctgaaagt gaccaacatg     1920

gaccctgccg acaccgccac ctactactgt gccagatcca tgatcaccaa ctggtacttc     1980

gacgtgtggg gagccggcac cacaaccgtc tcttcaggta agtctgctgt ctggggatag     2040

cggggagcca ggtgtactgg gccaggcaag ggctttggat cgtaggactg caagatcgct     2100

gcacagcagc gaatcgtgaa atattttctt tagaattatg aggtgcgctg tgtgtcaacc     2160

tgcatcttaa attctttatt ggctggaaag agaactgtcg gagtgggtga atccagccag     2220

gagggacgcg tagccccggt cttgatgaga gcagggttgg gggcaggggt agcccagaaa     2280

cggtggctgc cgtcctgaca ggggcttagg gaggctccag gacctcagtg ccttgaagct     2340

ggtttccatg agaaaaggat tgtttatctt aggaggcatg cttactgtta aaagacagga     2400

tatgtttgaa gtggcttctg agaaaaatgg ttaagaaaat tatgacttaa aaatgtgaga     2460

gattttcaag tatattaatt tttttaactg tccaagtatt tgaaattctt atcatttgat     2520

taacacccat g                                                          2531


<210>  103
<211>  3134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse anti-RSV emAb AAV

<400>  103
ccaggggtga ttctagtcag actctggggt ttttgtcggg tatagaggaa aaatccacta       60

ttgtgattac tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagg      120

taagaatggc ctctccaggt ctttattttt aacctttgtt atggagtttt ctgagcattg      180

cagactaatc ttggatattt gtccctgagg gagccggctg agagaagttg ggaaataaac      240

tgtctaggga tctcagagcc tttaggacag attatctcca catctttgaa aaactaagaa      300

tctgtgtgat ggtgttggtg gagtccctgg atgatgggat agggactttg gaggctcatt      360

tgagggagat gctaaaacaa tcctatggct ggagggatag ttggggctgt agttggagat      420

tttcagtttt tagaataaaa gtattagttg tggaatatac ttcaggacca cctctgtgac      480

agcatttata cagtatccga tggatgacaa gtgagtgtct caggttagga ttctatttta      540

agattgagat attaggcttt gatactacat ctaaatggtc tgtacatgtc tcgaagaaag      600

ttcttcagac agagttagga cttggatcca ggagttagga cttggactga ctcaggagga      660

ctctagtttc ttcttctcca gctggaatgt ccttatgtaa gaaaagcctt gcctcatgag      720

tatgcaaatc atgtgcgact gtgatgatta atatagggat atccacacca aacatcatat      780

gagccctatc ttctctacag acactgaatc tcaaggtcct tacaatggaa accgacacac      840

tgctgctgtg ggtgctgctt ctttgggtgc ccggaagcac aggcgacatc cagctgacac      900

agagccctgc catcatgtct gctagccctg gcgagaaagt gacaatgacc tgttccgcca      960

gcagctccgt gggctacatg cactggtatc agcagaagtc tagcacaagc cccaagctgt     1020

ggatctacga cacctccaag ctggcctctg gcgtgccagg cagattttct ggaagcggca     1080

gcggcaacag ctacagcctg actatcagct ccatccaggc cgaggatgtg gctacctact     1140

actgcttcag aggcagcggc taccccttca catttggcca gggcaccaag ctggaaatca     1200

aggccgatgc cgctcctacc gtgtctatct ttccacctag cagcgagcag ctgacatctg     1260

gcggagcctc tgtcgtgtgc ttcctgaaca acttctaccc taaggacatc aacgtcaagt     1320

ggaagatcga cggctccgag agacagaacg gcgtgctgaa ctcttggacc gaccaggaca     1380

gcaaggatag cacctacagc atgagcagca ctctgaccct gacaaaggac gagtacgaga     1440

ggcacaactc ctacacatgc gaggccacac acaagaccag cacatcccca atcgtgaagt     1500

ccttcaaccg gaacgagtgc ggaggaagta gtggcagcgg gagtgggtcc aattggagtc     1560

atcctcaatt tgagaaagga gggggagggt ccaattggtc tcatccgcag tttgagaagg     1620

gcggcggcgg ctccaattgg tcccatcccc agtttgaaaa aggctctggt ggaggtggta     1680

gtgctggtgg gcaggtggaa ctgcaagaaa gcggccctgg catcctgcag ccttctcaga     1740

cactgagcct gacctgtagc ttcagcggct tcagcctgag cacaagcggc atgtctgtcg     1800

gctggatcag acagccttct ggcgaaggac tggaatggct ggccgacatt tggtgggacg     1860

acaagaagga ctacaacccc agcctgaagt ccagactgac catcagcaag gacaccagca     1920

gcaaccaggt gttcctgaag atcaccggcg tggacacagc cgataccgcc acctattact     1980

gcgccagatc catgatcacc aactggtact tcgacgtgtg gggcgctggc accacagtga     2040

ccgtctcctc aggtgagtcc taacttctcc cattctaaat gcatgttggg gggattctgg     2100

gccttcagga ccaccatgta ccaaaagcca taacgatcgg tgggagtatt cattgtggtc     2160

aagatccata gggacaaaga gtggagtggg gcactttctt tagatttgtg aggaatgttc     2220

cgcactagat tgtttaaaac ttcatttgtt ggaaggagag ctgtcttagt gattgagtca     2280

agggagaaag gcatctagcc tcggtctcaa aagggtagtt gctgtctaga gaggtctggt     2340

ggagcctgca aaagtccagc tttcaaagga acacagaagt atgtgtatgg aatattagaa     2400

gatgttgctt ttactcttaa gttggttcct aggaaaaata gttaaatact gtgactttaa     2460

aatgtgagag ggttttcaag tactcatttt tttaaatgtc caaaattttt gtcaatcagt     2520

ttgaggtctt gtttgtgtag aactgatatt acttaaagtt taaccgagga atgggagtga     2580

ggctctctca taacctattc agaactgact tttaacaata ataaattaag tttaaaatat     2640

ttttaaatga attgagcaat gttgagttgg agtcaagatg gccgatcaga accagaacac     2700

ctgcagcagc tggcaggaag caggtcatgt ggcaaggcta tttggggaag ggaaaataaa     2760

accactaggt aaacttgtag ctgtggtttg aagaagtggt tttgaaacac tctgtccagc     2820

cccaccaaac cgaaagtcca ggctgagcaa aacaccacct gggtaatttg catttctaaa     2880

ataagttgag gattcagccg aaactggaga ggtcctcttt taacttattg agttcaacct     2940

tttaatttta gcttgagtag ttctagtttc cccaaactta agtttatcga cttctaaaat     3000

gtatttagaa ttcattttca aaattaggtt atgtaagaaa ttgaaggact ttagtgtctt     3060

taatttctaa tatatttaga aaacttctta aaattactct attattcttc cctctgatta     3120

ttggtctcca ttca                                                       3134


<210>  104
<211>  1736
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ms-emAb-RSV-dsDNA

<400>  104
accacctctg tgacagcatt tatacagtat ccgatggatg acaagtgagt gtctcaggtt       60

aggattctat tttaagattg agatattagg ctttgatact acatctaaat ggtctgtaca      120

tgtctcgaag aaagttcttc agacagagtt aggacttgga tccaggagtt aggacttgga      180

ctgactcagg aggactctag tttcttcttc tccagctgga atgtccttat gtaagaaaag      240

ccttgcctca tgagtatgca aatcatgtgc gactgtgatg attaatatag ggatatccac      300

accaaacatc atatgagccc tatcttctct acagacactg aatctcaagg tccttacaat      360

ggaaaccgac acactgctgc tgtgggtgct gcttctttgg gtgcccggaa gcacaggcga      420

catccagctg acacagagcc ctgccatcat gtctgctagc cctggcgaga aagtgacaat      480

gacctgttcc gccagcagct ccgtgggcta catgcactgg tatcagcaga agtctagcac      540

aagccccaag ctgtggatct acgacacctc caagctggcc tctggcgtgc caggcagatt      600

ttctggaagc ggcagcggca acagctacag cctgactatc agctccatcc aggccgagga      660

tgtggctacc tactactgct tcagaggcag cggctacccc ttcacatttg gccagggcac      720

caagctggaa atcaaggccg atgccgctcc taccgtgtct atctttccac ctagcagcga      780

gcagctgaca tctggcggag cctctgtcgt gtgcttcctg aacaacttct accctaagga      840

catcaacgtc aagtggaaga tcgacggctc cgagagacag aacggcgtgc tgaactcttg      900

gaccgaccag gacagcaagg atagcaccta cagcatgagc agcactctga ccctgacaaa      960

ggacgagtac gagaggcaca actcctacac atgcgaggcc acacacaaga ccagcacatc     1020

cccaatcgtg aagtccttca accggaacga gtgcggagga agtagtggca gcgggagtgg     1080

gtccaattgg agtcatcctc aatttgagaa aggaggggga gggtccaatt ggtctcatcc     1140

gcagtttgag aagggcggcg gcggctccaa ttggtcccat ccccagtttg aaaaaggctc     1200

tggtggaggt ggtagtgctg gtgggcaggt ggaactgcaa gaaagcggcc ctggcatcct     1260

gcagccttct cagacactga gcctgacctg tagcttcagc ggcttcagcc tgagcacaag     1320

cggcatgtct gtcggctgga tcagacagcc ttctggcgaa ggactggaat ggctggccga     1380

catttggtgg gacgacaaga aggactacaa ccccagcctg aagtccagac tgaccatcag     1440

caaggacacc agcagcaacc aggtgttcct gaagatcacc ggcgtggaca cagccgatac     1500

cgccacctat tactgcgcca gatccatgat caccaactgg tacttcgacg tgtggggcgc     1560

tggcaccaca gtgaccgtct cctcaggtga gtcctaactt ctcccattct aaatgcatgt     1620

tggggggatt ctgggccttc aggaccacca tgtaccaaaa gccataacga tcggtgggag     1680

tattcattgt ggtcaagatc catagggaca aagagtggag tggggcactt tcttta         1736


<210>  105
<211>  2551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu-emAb-VRC01-AAV

<400>  105
tgtgacgccc ggagacagaa ggtctctggg tggctgggtt tttgtggggt gaggatggac       60

attctgccat tgtgattact actactacta ctacatggac gtctggggca aagggaccac      120

ggtcaccgtc tcctcaggta agaatggcca ctctagggcc tttgttttct gctactgcct      180

gtggggtttc ctgagcattg caggttggtc ctcggggcat gttccgaggg gacctgggcg      240

gactggccag gaggggatgg gcactggggt gccttgagga tctgggagcc tctgtggatt      300

ttccgatgcc tttggaaaat gggactcagg ttgggtgcgt ctgatggagt aactgagcct      360

gggggcttgg ggagccacat ttggacgaga tgcctgaaca aaccaggggt cttagtgatg      420

gctgaggaat gtgtctcagg agcggtgtct gatcgtaatc tttaggccaa taaaatgtgg      480

gttcacagtg aggagtgcat cctggggttg gggtttgttc tgcagcggga agagcgctgt      540

gcacagaaag cttagaaatg gggcaagaga tgcttttcct caggcaggat ttagggcttg      600

gtctctcagc atcccacact tgtacagctg atgtggcatc tgtgttttct ttctcatcct      660

agatcaggct ttgagctgtg aaataccctg cctcatgcat atgcaaataa cctgaggtct      720

tctgagataa atatagatat attggtgccc tgagagcatc acgccgccac catggctacc      780

ggcagcagaa caagcctgct gctcgctttt ggactgctct gtctcccctg gttgcaagaa      840

ggcagcgccg aaattgtgtt gacacagtct ccaggcaccc tgtctttgtc tccaggggaa      900

acagccatca tctcttgtcg gaccagtcag tatggttcct tagcctggta tcaacagagg      960

cccggccagg cccccaggct cgtcatctat tcgggctcta ctcgggccgc tggcatccca     1020

gacaggttca gcggcagtcg gtgggggcca gactacaatc tcaccatcag caacctggag     1080

tcgggagatt ttggtgttta ttattgccag cagtatgaat tttttggcca ggggaccaag     1140

gtccaggtcg acattaagcg cactgtggcc gctcctagcg tgttcatctt tccacctagc     1200

gacgagcagc tgaagtctgg cactgcctct gtcgtgtgcc tgctgaacaa cttctaccct     1260

cgagaggcca aggtgcagtg gaaagtggac aatgccctgc agagcggcaa cagccaagag     1320

tctgtgaccg agcaggactc caaggattcc acctacagcc tgtctagcac cctgactctg     1380

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgacaca ccagggactg     1440

agcagccctg tgaccaagag cttcaatcgg ggcgagtgcg gaggctcaag tggctccggg     1500

agtgggagca attggtcaca cccccagttt gaaaaaggcg gtggggggag taactggtct     1560

catccgcagt tcgaaaaggg tggaggaggg agcaactgga gtcatccaca atttgagaaa     1620

ggctcaggtg gtggtggtag cgctgggggg caggtgcagc tggtgcagtc tgggggtcag     1680

atgaagaagc ctggcgagtc gatgagaatt tcttgtcggg cttctggata tgaatttatt     1740

gattgtacgc taaattggat tcgtctggcc cccggaaaaa ggcctgagtg gatgggatgg     1800

ctgaagcctc gaggtggcgc ggtcaactac gcacgtccac ttcagggcag agtgaccatg     1860

actcgagacg tttattccga cacagccttt ttggagctgc gctcgttgac agtagacgac     1920

acggccgtct acttttgtac taggggaaaa aactgtgatt acaattggga cttcgaacac     1980

tggggccggg gcaccccggt catcgtctca tcaggtgagt tggctttcct tctgcctcct     2040

ttctctgggc ccagcgtcct ctgacctgga gctgggagat aatgtccggg ggctccttat     2100

cgtaggactg caagatcgct gcacagcagc gaatcgtgaa atattttctt tagaattatg     2160

aggtgcgctg tgtgtcaacc tgcatcttaa attctttatt ggctggaaag agaactgtcg     2220

gagtgggtga atccagccag gagggacgcg tagccccggt cttgatgaga gcagggttgg     2280

gggcaggggt agcccagaaa cggtggctgc cgtcctgaca ggggcttagg gaggctccag     2340

gacctcagtg ccttgaagct ggtttccatg agaaaaggat tgtttatctt aggaggcatg     2400

cttactgtta aaagacagga tatgtttgaa gtggcttctg agaaaaatgg ttaagaaaat     2460

tatgacttaa aaatgtgaga gattttcaag tatattaatt tttttaactg tccaagtatt     2520

tgaaattctt atcatttgat taacacccat g                                    2551


<210>  106
<211>  2544
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu-emAb-Medi8852-AAV

<400>  106
tgtgacgccc ggagacagaa ggtctctggg tggctgggtt tttgtggggt gaggatggac       60

attctgccat tgtgattact actactacta ctacatggac gtctggggca aagggaccac      120

ggtcaccgtc tcctcaggta agaatggcca ctctagggcc tttgttttct gctactgcct      180

gtggggtttc ctgagggcat gttccgaggg gacctgggcg gactggccag gaggggatgg      240

gcactggggt gccttgagga tctgggagcc tctgtggatt ttccgatgcc tttggaaaat      300

gggactcagg ttgggtgcgt ctgatggagt aactgagcct gggggcttgg ggagccacat      360

ttggacgaga tgcctgaaca aaccaggggt cttagtgatg gctgaggaat gtgtctcagg      420

agcggtgtct gatcgtaatc tttaggccaa taaaatgtgg gttcacagtg aggagtgcat      480

cctggggttg gggtttgttc tgcagcggga agagcgctgt gcacagaaag cttagaaatg      540

gggcaagaga tgcttttcct caggcaggat ttagggcttg gtctctcagc atcccacact      600

tgtacagctg atgtggcatc tgtgttttct ttctcatcct agatcaggct ttgagctgtg      660

aaataccctg cctcatgcat atgcaaataa cctgaggtct tctgagataa atatagatat      720

attggtgccc tgaggccgcc accatggcta ccggcagcag aacaagcctg ctgctcgctt      780

ttggactgct ctgtctcccc tggttgcaag aaggcagcgc cgatattcag atgacccaga      840

gcccttccag cctgtccgct tcagtggggg atcgagtgac cattacctgc cgaaccagcc      900

agagcctgag ctcctacacg cactggtatc agcagaagcc cggcaaagcc cctaagctgc      960

tgatctacgc cgcttctagt cgggggtccg gagtgccaag ccggttctcc ggatctggga     1020

gtggaaccga ctttaccctg acaatttcaa gcctgcagcc cgaggatttc gctacatact     1080

actgtcagca gagcagaact ttcgggcagg gcactaaggt ggagatcaaa cggactgtgg     1140

ccgctcctag cgtgttcatc tttccaccta gcgacgagca gctgaagtct ggcactgcct     1200

ctgtcgtgtg cctgctgaac aacttctacc ctcgagaggc caaggtgcag tggaaagtgg     1260

acaatgccct gcagagcggc aacagccaag agtctgtgac cgagcaggac tccaaggatt     1320

ccacctacag cctgtctagc accctgactc tgagcaaggc cgactacgag aagcacaagg     1380

tgtacgcctg cgaagtgaca caccagggac tgagcagccc tgtgaccaag agcttcaatc     1440

ggggcgagtg cggaggaagt agtggcagcg ggagtgggtc caattggagt catcctcaat     1500

ttgagaaagg agggggaggg tccaattggt ctcatccgca gtttgagaag ggcggcggcg     1560

gctccaattg gtcccatccc cagtttgaaa aaggctctgg tggaggtggt agtgctggtg     1620

ggcaggtcca gctgcagcag agcggccccg gactggtcaa gccttcacag acactgagcc     1680

tgacatgcgc cattagcgga gatagcgtga gctcctacaa tgccgtgtgg aactggatca     1740

ggcagtctcc aagtcgagga ctggagtggc tgggacgaac atactataga tccgggtggt     1800

acaatgacta tgctgaatca gtgaaaagcc gaattactat caaccccgat acctccaaga     1860

atcagttctc tctgcagctg aacagtgtga cccctgagga cacagccgtg tactactgcg     1920

ccagaagcgg ccatatcacc gtctttggcg tcaatgtgga tgctttcgat atgtgggggc     1980

aggggactat ggtcaccgtc tcttcaggtg agttggcttt ccttctgcct cctttctctg     2040

ggcccagcgt cctctgacct ggagctggga gataatgtcc gggggctcct tatcgtagga     2100

ctgcaagatc gctgcacagc agcgaatcgt gaaatatttt ctttagaatt atgaggtgcg     2160

ctgtgtgtca acctgcatct taaattcttt attggctgga aagagaactg tcggagtggg     2220

tgaatccagc caggagggac gcgtagcccc ggtcttgatg agagcagggt tgggggcagg     2280

ggtagcccag aaacggtggc tgccgtcctg acaggggctt agggaggctc caggacctca     2340

gtgccttgaa gctggtttcc atgagaaaag gattgtttat cttaggaggc atgcttactg     2400

ttaaaagaca ggatatgttt gaagtggctt ctgagaaaaa tggttaagaa aattatgact     2460

taaaaatgtg agagattttc aagtatatta atttttttaa ctgtccaagt atttgaaatt     2520

cttatcattt gattaacacc catg                                            2544


<210>  107
<211>  2555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hu-emAb-AMM01-AAV

<400>  107
tgtgacgccc ggagacagaa ggtctctggg tggctgggtt tttgtggggt gaggatggac       60

attctgccat tgtgattact actactacta ctacatggac gtctggggca aagggaccac      120

ggtcaccgtc tcctcaggta agaatggcca ctctagggcc tttgttttct gctactgcct      180

gtggggtttc ctgagggcat gttccgaggg gacctgggcg gactggccag gaggggatgg      240

gcactggggt gccttgagga tctgggagcc tctgtggatt ttccgatgcc tttggaaaat      300

gggactcagg ttgggtgcgt ctgatggagt aactgagcct gggggcttgg ggagccacat      360

ttggacgaga tgcctgaaca aaccaggggt cttagtgatg gctgaggaat gtgtctcagg      420

agcggtgtct gatcgtaatc tttaggccaa taaaatgtgg gttcacagtg aggagtgcat      480

cctggggttg gggtttgttc tgcagcggga agagcgctgt gcacagaaag cttagaaatg      540

gggcaagaga tgcttttcct caggcaggat ttagggcttg gtctctcagc atcccacact      600

tgtacagctg atgtggcatc tgtgttttct ttctcatcct agatcaggct ttgagctgtg      660

aaataccctg cctcatgcat atgcaaataa cctgaggtct tctgagataa atatagatat      720

attggtgccc tgagagcatc acgccgccac catggctacc ggcagcagaa caagcctgct      780

gctcgctttt ggactgctct gtctcccctg gttgcaagaa ggcagcgcct cctatgagct      840

gactcagcca ccctcagtgt cagtggcccc ggggcagagg gccacaatta cctgtggggg      900

acacaacatc ggagctaaaa atgtccactg gtaccagcag aagccaggcc aggcccctgt      960

cctggtcatc caatatgata gcgaccggcc ctcagggatc cctgagcgat tctctggctc     1020

caactctggg agcacggcca ccctgaccat cagcagggtc gaagccgggg atgaggccga     1080

ctattactgt caggtgtggg atagtggtcg tgggcatccc ctttatgtct tcggaggtgg     1140

gaccaaggtc accgtcctag gtcagcccaa ggccaacccc actgtcactc tgttcccacc     1200

ctcgagtgag gagcttcaag ccaacaaggc cacactggtg tgtctcataa gtgacttcta     1260

cccgggagcc gtgacagtgg cctggaaggc agatagcagc cccgtcaagg cgggagtgga     1320

gaccaccaca ccctccaaac aaagcaacaa caagtacgcg gccagcagct acctgagcct     1380

gacgcctgag cagtggaagt cccacagaag ctacagctgc caggtcacgc atgaagggag     1440

caccgtggag aagacagtgg cccctacaga atgttcagga ggaagtagtg gcagcgggag     1500

tgggtccaat tggagtcatc ctcaatttga gaaaggaggg ggagggtcca attggtctca     1560

tccgcagttt gagaagggcg gcggcggctc caattggtcc catccccagt ttgaaaaagg     1620

ctctggtgga ggtggtagtg ctggtgggca ggttcagctg gtgcagtctg gagctgatgt     1680

gaagaagcct ggggcctcag tgaaggtctc ctgcaaggct tctggttaca cctttattca     1740

ttttggtatc agttgggtgc ggcaggcccc tggacaaggg cttgagtgga tgggatggat     1800

cgacactaat aatggtaaca caaactatgc acagagtctc cagggcagag tcaccatgac     1860

cacagataca tccacgggca cagcctacat ggagctgagg agcctctcga ctgacgacac     1920

ggccgtgtat ttctgtgcgc gagctctgga aatggggcat agaagtggct tcccatttga     1980

ctactggggc cagggagtcc tggtcaccgt ctccccaggt gagttggctt tccttctgcc     2040

tcctttctct gggcccagcg tcctctgacc tggagctggg agataatgtc cgggggctcc     2100

ttatcgtagg actgcaagat cgctgcacag cagcgaatcg tgaaatattt tctttagaat     2160

tatgaggtgc gctgtgtgtc aacctgcatc ttaaattctt tattggctgg aaagagaact     2220

gtcggagtgg gtgaatccag ccaggaggga cgcgtagccc cggtcttgat gagagcaggg     2280

ttgggggcag gggtagccca gaaacggtgg ctgccgtcct gacaggggct tagggaggct     2340

ccaggacctc agtgccttga agctggtttc catgagaaaa ggattgttta tcttaggagg     2400

catgcttact gttaaaagac aggatatgtt tgaagtggct tctgagaaaa atggttaaga     2460

aaattatgac ttaaaaatgt gagagatttt caagtatatt aattttttta actgtccaag     2520

tatttgaaat tcttatcatt tgattaacac ccatg                                2555


<210>  108
<211>  2261
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Balb/C mRSV-splice integration

<400>  108
ctactggggt caaggaacct cagtcaccgt ctcctcaggt aagaatggcc tctccaggtc       60

tttattttta acctttgtta tggagttttc tgagcattgc agactaatct tggatatttg      120

tccctgaggg agccggctga gagaagttgg gaaataaact gtctagggat ctcagagcct      180

ttaggacaga ttatctccac atctttgaaa aactaagaat ctgtgtgatg gtgttggtgg      240

agtccctgga tgatgggata gggactttgg aggctcattt gaagaagatg ctaaaacaat      300

cctatggctg gagggatagt tggggctgta gttggagatt ttcagttttt agaataaaag      360

tattagttgt ggaatatact tcaggaccac ctctgtgaca gcatttatac agtatccgat      420

ggacaagtga gtgtctcagg ttaggattct attttaagat tgagatatta ggctttgata      480

ctacatctaa atggtctgta catgtctcga agaaagttct tcagacagag ttaggacttg      540

gatccaggag ttaggacttg gactgactca ggaggactct agtttcttct tctccagctg      600

gaatgtcctt atgtaagaaa agccttgcct catgagtatg caaatcatgt gcgactgtga      660

tgattaatat agggatatcc acaccaaaca tcatatgagc cctatcttct ctacagacac      720

tgaatctcaa ggtccttaca atggaaaccg acacactgct gctgtgggtg ctgcttcttt      780

gggtgcccgg aagcacaggc gacatccagc tgacacagag ccctgccatc atgtctgcta      840

gccctggcga gaaagtgaca atgacctgtt ccgccagcag ctccgtgggc tacatgcact      900

ggtatcagca gaagtctagc acaagcccca agctgtggat ctacgacacc tccaagctgg      960

cctctggcgt gccaggcaga ttttctggaa gcggcagcgg caacagctac agcctgacta     1020

tcagctccat ccaggccgag gatgtggcta cctactactg cttcagaggc agcggctacc     1080

ccttcacatt tggccagggc accaagctgg aaatcaaggc cgatgccgct cctaccgtgt     1140

ctatctttcc acctagcagc gagcagctga catctggcgg agcctctgtc gtgtgcttcc     1200

tgaacaactt ctaccctaag gacatcaacg tcaagtggaa gatcgacggc tccgagagac     1260

agaacggcgt gctgaactct tggaccgacc aggacagcaa ggatagcacc tacagcatga     1320

gcagcactct gaccctgaca aaggacgagt acgagaggca caactcctac acatgcgagg     1380

ccacacacaa gaccagcaca tccccaatcg tgaagtcctt caaccggaac gagtgcggag     1440

gaagtagtgg cagcgggagt gggtccaatt ggagtcatcc tcaatttgag aaaggagggg     1500

gagggtccaa ttggtctcat ccgcagtttg agaagggcgg cggcggctcc aattggtccc     1560

atccccagtt tgaaaaaggc tctggtggag gtggtagtgc tggtgggcag gtggaactgc     1620

aagaaagcgg ccctggcatc ctgcagcctt ctcagacact gagcctgacc tgtagcttca     1680

gcggcttcag cctgagcaca agcggcatgt ctgtcggctg gatcagacag ccttctggcg     1740

aaggactgga atggctggcc gacatttggt gggacgacaa gaaggactac aaccccagcc     1800

tgaagtccag actgaccatc agcaaggaca ccagcagcaa ccaggtgttc ctgaagatca     1860

ccggcgtgga cacagccgat accgccacct attactgcgc cagatccatg atcaccaact     1920

ggtacttcga cgtgtggggc gctggcacca cagtgaccgt ctcctcaggt gagtcctaac     1980

ttctcccatt ctaaatgcat gttgggggga ttctgggcct tcaggaccac atagggacaa     2040

agagtggagt ggggcacttt ctttagattt gtgaggaatg ttccgcacta gattgtttaa     2100

aacttcattt gttggaagga gagctgtctt agtgattgag tcaagggaga aaggcatcta     2160

gcctcggtct caaaagggta gttgctgtct agagaggtct ggtggagcct gcaaaagtcc     2220

agctttcaaa ggaacacaga agtatgtgta tggaatatta g                         2261


<210>  109
<211>  1707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TT-hRSV-T7-integrated

<400>  109
gtcttagtga tggctgagga atgtgtctca ggagcggtgt ccgtaatctt taggccaata       60

aaatgtgggt tcacagtgag gagtgcatcc tggggttggg gtttgttctg cagcgggaag      120

agcgctgtgc acagaaagct tagaaatggg gcaagagatg cttttcctca ggcaggattt      180

agggcttggt ctctcagcat cccacacttg tacagctgat gtggcatctg tgttttcttt      240

ctcatcctag atcaggcttt gagctgtgaa ataccctgcc tcatgcatat gcaaataacc      300

tgaggtcttc tgagataaat atagatatat tggtgccctg aggtttaaac gccgccacca      360

tggctaccgg cagcagaaca agcctgctgc tcgcttttgg actgctctgt ctcccctggt      420

tgcaagaagg cagcgccgac atccagatga cacagagccc tagcacactg tctgccagcg      480

tgggcgacag agtgaccatc acatgcaagt gccagctgag cgtgggctac atgcactggt      540

atcagcaaaa gcccggcaag gcccctaagc tgctgatcta cgatacctcc aagctggcct      600

ctggcgtgcc ctccagattt tctggcagcg gcagcggaac cgagttcacc ctgaccatct      660

caagcctgca gcctgacgac ttcgctacgt actactgctt ccaaggcagc ggctacccct      720

tcacatttgg cggcggaaca aagctggaaa tcaagcggac tgtggccgct cctagcgtgt      780

tcatctttcc acctagcgac gagcagctga agtctggcac tgcctctgtc gtgtgcctgc      840

tgaacaactt ctaccctcga gaggccaagg tgcagtggaa agtggacaat gccctgcaga      900

gcggcaacag ccaagagtct gtgaccgagc aggactccaa ggattccacc tacagcctgt      960

ctagcaccct gactctgagc aaggccgact acgagaagca caaggtgtac gcctgcgaag     1020

tgacacacca gggactgagc agccctgtga ccaagagctt caatcggggc gagtgcggag     1080

gaagtagtgg cagcgggagt gggtccaatt ggagtcatcc tcaatttgag aaaggagggg     1140

gagggtccaa ttggtctcat ccgcagtttg agaagggcgg cggcggctcc aattggtccc     1200

atccccagtt tgaaaaaggc tctggtggag gtggtagtgc tggtgggcaa gtgaccctga     1260

gagagtctgg acctgctctg gtcaagccca cacagaccct gacactgacc tgcaccttca     1320

gcggctttag cctgagcaca agcggcatga gcgtcggctg gattagacag cctcctggca     1380

aagccctgga atggctggcc gacatttggt gggacgacaa gaaggactac aaccccagcc     1440

tgaagtcccg gctgaccatc agcaaggaca ccagcaagaa ccaggtggtg ctgaaagtga     1500

ccaacatgga ccctgccgac accgccacct actactgtgc cagatccatg atcaccaact     1560

ggtacttcga cgtgtgggga gccggcacca caaccgtctc ttcaggtaag tctgctgtct     1620

ggggatagcg gggagccagg tgtactgggc caggcaaggg ctttggtgta ggactgcaag     1680

atcgctgcac agcagcgaat cgtgaaa                                         1707


<210>  110
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  110
tgtgacgccc ggagacagaa ggtctctggg tggctgggtt tttgtggggt gaggatggac       60

attctgccat tgtgattact actactacta ctacatggac gtctggggca aagggaccac      120

ggtcaccgtc tcctcaggta agaatggcca ctctagggcc tttgttttct gctactgcct      180

gtggggtttc ctgagcattg caggttggtc ctcggggcat gttccgaggg gacctgggcg      240

gactggccag gaggggatgg gcactggggt gccttgagga tctgggagcc tctgtggatt      300

ttccgatgcc tttggaaaat gggactcagg ttgggtgcgt ctgatggagt aactgagcct      360

gggggcttgg ggagccacat ttggacgaga tgcctgaaca aaccaggggt cttagtgatg      420

gctgaggaat gtgtctcagg agcggtgtct                                       450


<210>  111
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  111
gtaatcttta ggccaataaa atgtgggttc acagtgagga gtgcatcctg gggttggggt       60

ttgttctgca gcgggaagag cgctgtgcac agaaagctta gaaatggggc aagagatgct      120

tttcctcagg caggatttag ggcttggtct ctcagcatcc cacacttgta cagctgatgt      180

ggcatctgtg ttttctttct catcctagat caggctttga gctgtgaaat accctgcctc      240

atgcatatgc aaataacctg aggtcttctg agataaatat agatatattg gtgccctgag      300


<210>  112
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide coding sequence

<400>  112
atggctaccg gcagcagaac aagcctgctg ctcgcttttg gactgctctg tctcccctgg       60

ttgcaagaag gcagcgcc                                                     78


<210>  113
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRSV light chain coding sequence

<400>  113
atggctaccg gcagcagaac aagcctgctg ctcgcttttg gactgctctg tctcccctgg       60

ttgcaagaag gcagcgccga catccagatg acacagagcc ctagcacact gtctgccagc      120

gtgggcgaca gagtgaccat cacatgcaag tgccagctga gcgtgggcta catgcactgg      180

tatcagcaaa agcccggcaa ggcccctaag ctgctgatct acgatacctc caagctggcc      240

tctggcgtgc cctccagatt ttctggcagc ggcagcggaa ccgagttcac cctgaccatc      300

tcaagcctgc agcctgacga cttcgctacg tactactgct tccaaggcag cggctacccc      360

ttcacatttg gcggcggaac aaagctggaa atcaagcgga ctgtggccgc tcctagcgtg      420

ttcatctttc cacctagcga cgagcagctg aagtctggca ctgcctctgt cgtgtgcctg      480

ctgaacaact tctaccctcg agaggccaag gtgcagtgga aagtggacaa tgccctgcag      540

agcggcaaca gccaagagtc tgtgaccgag caggactcca aggattccac ctacagcctg      600

tctagcaccc tgactctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      660

gtgacacacc agggactgag cagccctgtg accaagagct tcaatcgggg cgagtgc         717


<210>  114
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRSV variable light chain coding sequence

<400>  114
gacatccaga tgacacagag ccctagcaca ctgtctgcca gcgtgggcga cagagtgacc       60

atcacatgca agtgccagct gagcgtgggc tacatgcact ggtatcagca aaagcccggc      120

aaggccccta agctgctgat ctacgatacc tccaagctgg cctctggcgt gccctccaga      180

ttttctggca gcggcagcgg aaccgagttc accctgacca tctcaagcct gcagcctgac      240

gacttcgcta cgtactactg cttccaaggc agcggctacc ccttcacatt tggcggcgga      300

acaaagctgg aaatcaagcg g                                                321


<210>  115
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  kappa constant light chain coding sequence

<400>  115
actgtggccg ctcctagcgt gttcatcttt ccacctagcg acgagcagct gaagtctggc       60

actgcctctg tcgtgtgcct gctgaacaac ttctaccctc gagaggccaa ggtgcagtgg      120

aaagtggaca atgccctgca gagcggcaac agccaagagt ctgtgaccga gcaggactcc      180

aaggattcca cctacagcct gtctagcacc ctgactctga gcaaggccga ctacgagaag      240

cacaaggtgt acgcctgcga agtgacacac cagggactga gcagccctgt gaccaagagc      300

ttcaatcggg gcgagtgc                                                    318


<210>  116
<211>  171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GSSG-streptag linker coding sequence

<400>  116
ggaggaagta gtggcagcgg gagtgggtcc aattggagtc atcctcaatt tgagaaagga       60

gggggagggt ccaattggtc tcatccgcag tttgagaagg gcggcggcgg ctccaattgg      120

tcccatcccc agtttgaaaa aggctctggt ggaggtggta gtgctggtgg g               171


<210>  117
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRSV variable heavy chain coding sequence

<400>  117
caagtgaccc tgagagagtc tggacctgct ctggtcaagc ccacacagac cctgacactg       60

acctgcacct tcagcggctt tagcctgagc acaagcggca tgagcgtcgg ctggattaga      120

cagcctcctg gcaaagccct ggaatggctg gccgacattt ggtgggacga caagaaggac      180

tacaacccca gcctgaagtc ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgaaag tgaccaacat ggaccctgcc gacaccgcca cctactactg tgccagatcc      300

atgatcacca actggtactt cgacgtgtgg ggagccggca ccacaaccgt ctcttca         357


<210>  118
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide amino acid sequence

<400>  118

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala 
            20                  25      


<210>  119
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRSV light chain amino acid sequence

<400>  119

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Lys Cys Gln Leu Ser Val Gly Tyr Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  120
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRSV variable light chain amino acid sequence

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  121
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kappa constant light chain amino acid sequence

<400>  121

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  122
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GSSG-streptag linker amino acid sequence

<400>  122

Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Asn Trp Ser His Pro Gln 
1               5                   10                  15      


Phe Glu Lys Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
            20                  25                  30          


Lys Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
        35                  40                  45              


Ser Gly Gly Gly Gly Ser Ala Gly Gly 
    50                  55          


<210>  123
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRSV variable heavy chain amino acid sequence

<400>  123

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Val Thr Asn Met Asp Pro Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Thr Val Ser Ser 
        115                 


<210>  124
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice junction with flanking sequence in constructs of 
       disclosure

<400>  124
caggtaagtc tgctgtctgg ggatagcggg gagccaggtg tactgggcca ggcaagggct       60

ttggatc                                                                 67


<210>  125
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  125
gtaggactgc aagatcgctg cacagcagcg aatcgtgaaa tattttcttt agaattatga       60

ggtgcgctgt gtgtcaacct gcatcttaaa ttctttattg gctggaaaga gaactgtcgg      120

agtgggtgaa tccagccagg agggacgcgt agccccggtc ttgatgagag cagggttggg      180

ggcaggggta gcccagaaac ggtggctgcc gtcctgacag gggcttaggg aggctccagg      240

acctcagtgc cttgaagctg gtttccatga gaaaaggatt gtttatctta ggaggcatgc      300

ttactgttaa aagacaggat atgtttgaag tggcttctga gaaaaatggt taagaaaatt      360

atgacttaaa aatgtgagag attttcaagt atattaattt ttttaactgt ccaagtattt      420

gaaattctta tcatttgatt aacacccatg                                       450


<210>  126
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in human anti-RSV emAb AAV

<400>  126

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Lys Cys Gln Leu Ser Val Gly Tyr Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
225                 230                 235                 240 


Gly Ser Ser Gly Ser Gly Ser Gly Ser Asn Trp Ser His Pro Gln Phe 
                245                 250                 255     


Glu Lys Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Ala Gly Gly Gln Val Thr Leu Arg Glu Ser Gly 
    290                 295                 300                 


Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe 
305                 310                 315                 320 


Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg 
                325                 330                 335     


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp 
            340                 345                 350         


Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser 
        355                 360                 365             


Lys Asp Thr Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp 
    370                 375                 380                 


Pro Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn 
385                 390                 395                 400 


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Thr Val Ser Ser 
                405                 410                 415 


<210>  127
<211>  502
<212>  DNA
<213>  Mus musculus

<400>  127
ccaggggtga ttctagtcag actctggggt ttttgtcggg tatagaggaa aaatccacta       60

ttgtgattac tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagg      120

taagaatggc ctctccaggt ctttattttt aacctttgtt atggagtttt ctgagcattg      180

cagactaatc ttggatattt gtccctgagg gagccggctg agagaagttg ggaaataaac      240

tgtctaggga tctcagagcc tttaggacag attatctcca catctttgaa aaactaagaa      300

tctgtgtgat ggtgttggtg gagtccctgg atgatgggat agggactttg gaggctcatt      360

tgagggagat gctaaaacaa tcctatggct ggagggatag ttggggctgt agttggagat      420

tttcagtttt tagaataaaa gtattagttg tggaatatac ttcaggacca cctctgtgac      480

agcatttata cagtatccga tg                                               502


<210>  128
<211>  319
<212>  DNA
<213>  Mus musculus

<400>  128
gacaagtgag tgtctcaggt taggattcta ttttaagatt gagatattag gctttgatac       60

tacatctaaa tggtctgtac atgtctcgaa gaaagttctt cagacagagt taggacttgg      120

atccaggagt taggacttgg actgactcag gaggactcta gtttcttctt ctccagctgg      180

aatgtcctta tgtaagaaaa gccttgcctc atgagtatgc aaatcatgtg cgactgtgat      240

gattaatata gggatatcca caccaaacat catatgagcc ctatcttctc tacagacact      300

gaatctcaag gtccttaca                                                   319


<210>  129
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide coding sequence

<400>  129
atggaaaccg acacactgct gctgtgggtg ctgcttcttt gggtgcccgg aagcacaggc       60


<210>  130
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRSV kappa light chain coding sequence

<400>  130
atggaaaccg acacactgct gctgtgggtg ctgcttcttt gggtgcccgg aagcacaggc       60

gacatccagc tgacacagag ccctgccatc atgtctgcta gccctggcga gaaagtgaca      120

atgacctgtt ccgccagcag ctccgtgggc tacatgcact ggtatcagca gaagtctagc      180

acaagcccca agctgtggat ctacgacacc tccaagctgg cctctggcgt gccaggcaga      240

ttttctggaa gcggcagcgg caacagctac agcctgacta tcagctccat ccaggccgag      300

gatgtggcta cctactactg cttcagaggc agcggctacc ccttcacatt tggccagggc      360

accaagctgg aaatcaaggc cgatgccgct cctaccgtgt ctatctttcc acctagcagc      420

gagcagctga catctggcgg agcctctgtc gtgtgcttcc tgaacaactt ctaccctaag      480

gacatcaacg tcaagtggaa gatcgacggc tccgagagac agaacggcgt gctgaactct      540

tggaccgacc aggacagcaa ggatagcacc tacagcatga gcagcactct gaccctgaca      600

aaggacgagt acgagaggca caactcctac acatgcgagg ccacacacaa gaccagcaca      660

tccccaatcg tgaagtcctt caaccggaac gagtgc                                696


<210>  131
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPalivizumab variable light chain coding sequence

<400>  131
gacatccagc tgacacagag ccctgccatc atgtctgcta gccctggcga gaaagtgaca       60

atgacctgtt ccgccagcag ctccgtgggc tacatgcact ggtatcagca gaagtctagc      120

acaagcccca agctgtggat ctacgacacc tccaagctgg cctctggcgt gccaggcaga      180

ttttctggaa gcggcagcgg caacagctac agcctgacta tcagctccat ccaggccgag      240

gatgtggcta cctactactg cttcagaggc agcggctacc ccttcacatt tggccagggc      300

accaagctgg aaatcaag                                                    318


<210>  132
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mIgL kappa constant light chain coding sequence

<400>  132
gccgatgccg ctcctaccgt gtctatcttt ccacctagca gcgagcagct gacatctggc       60

ggagcctctg tcgtgtgctt cctgaacaac ttctacccta aggacatcaa cgtcaagtgg      120

aagatcgacg gctccgagag acagaacggc gtgctgaact cttggaccga ccaggacagc      180

aaggatagca cctacagcat gagcagcact ctgaccctga caaaggacga gtacgagagg      240

cacaactcct acacatgcga ggccacacac aagaccagca catccccaat cgtgaagtcc      300

ttcaaccgga acgagtgc                                                    318


<210>  133
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mPalivizumab variable heavy chain coding sequence

<400>  133
caggtggaac tgcaagaaag cggccctggc atcctgcagc cttctcagac actgagcctg       60

acctgtagct tcagcggctt cagcctgagc acaagcggca tgtctgtcgg ctggatcaga      120

cagccttctg gcgaaggact ggaatggctg gccgacattt ggtgggacga caagaaggac      180

tacaacccca gcctgaagtc cagactgacc atcagcaagg acaccagcag caaccaggtg      240

ttcctgaaga tcaccggcgt ggacacagcc gataccgcca cctattactg cgccagatcc      300

atgatcacca actggtactt cgacgtgtgg ggcgctggca ccacagtgac cgtctcctca      360


<210>  134
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide amino acid sequence

<400>  134

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  135
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mRSV kappa light chain amino acid sequence

<400>  135

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Val Gly Tyr Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys 
    50                  55                  60                  


Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Ile Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly 
            100                 105                 110         


Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230         


<210>  136
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mPalivizumab variable light chain amino acid sequence

<400>  136

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Ile Gln Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  137
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mIgL kappa constant light chain amino acid sequence

<400>  137

Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
1               5                   10                  15      


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
        35                  40                  45              


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
65                  70                  75                  80  


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
                85                  90                  95      


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105     


<210>  138
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mPalivizumab variable heavy chain amino acid sequence

<400>  138

Gln Val Glu Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Ser Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Gly Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  139
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice junction with flanking sequence

<400>  139
caggtgagtc ctaacttctc ccattctaaa tgcatgttgg ggggattctg ggccttcagg       60

acca                                                                    64


<210>  140
<211>  968
<212>  DNA
<213>  Mus musculus

<400>  140
catagggaca aagagtggag tggggcactt tctttagatt tgtgaggaat gttccgcact       60

agattgttta aaacttcatt tgttggaagg agagctgtct tagtgattga gtcaagggag      120

aaaggcatct agcctcggtc tcaaaagggt agttgctgtc tagagaggtc tggtggagcc      180

tgcaaaagtc cagctttcaa aggaacacag aagtatgtgt atggaatatt agaagatgtt      240

gcttttactc ttaagttggt tcctaggaaa aatagttaaa tactgtgact ttaaaatgtg      300

agagggtttt caagtactca tttttttaaa tgtccaaaat ttttgtcaat cagtttgagg      360

tcttgtttgt gtagaactga tattacttaa agtttaaccg aggaatggga gtgaggctct      420

ctcataacct attcagaact gacttttaac aataataaat taagtttaaa atatttttaa      480

atgaattgag caatgttgag ttggagtcaa gatggccgat cagaaccaga acacctgcag      540

cagctggcag gaagcaggtc atgtggcaag gctatttggg gaagggaaaa taaaaccact      600

aggtaaactt gtagctgtgg tttgaagaag tggttttgaa acactctgtc cagccccacc      660

aaaccgaaag tccaggctga gcaaaacacc acctgggtaa tttgcatttc taaaataagt      720

tgaggattca gccgaaactg gagaggtcct cttttaactt attgagttca accttttaat      780

tttagcttga gtagttctag tttccccaaa cttaagttta tcgacttcta aaatgtattt      840

agaattcatt ttcaaaatta ggttatgtaa gaaattgaag gactttagtg tctttaattt      900

ctaatatatt tagaaaactt cttaaaatta ctctattatt cttccctctg attattggtc      960

tccattca                                                               968


<210>  141
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in mouse anti-RSV emAb AAV

<400>  141

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Val Gly Tyr Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys 
    50                  55                  60                  


Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Ile Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly 
            100                 105                 110         


Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys Gly Gly Ser Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
                245                 250                 255     


Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Asn Trp 
            260                 265                 270         


Ser His Pro Gln Phe Glu Lys Gly Ser Gly Gly Gly Gly Ser Ala Gly 
        275                 280                 285             


Gly Gln Val Glu Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser 
    290                 295                 300                 


Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr 
305                 310                 315                 320 


Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu 
                325                 330                 335     


Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro 
            340                 345                 350         


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln 
        355                 360                 365             


Val Phe Leu Lys Ile Thr Gly Val Asp Thr Ala Asp Thr Ala Thr Tyr 
    370                 375                 380                 


Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly 
385                 390                 395                 400 


Ala Gly Thr Thr Val Thr Val Ser Ser 
                405                 


<210>  142
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  142
accacctctg tgacagcatt tatacagtat ccgatggat                              39


<210>  143
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  143
atccataggg acaaagagtg gagtggggca ctttcttta                              39


<210>  144
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in ms-emAb-RSV-dsDNA

<400>  144

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Val Gly Tyr Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys 
    50                  55                  60                  


Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Ile Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly 
            100                 105                 110         


Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys Gly Gly Ser Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
                245                 250                 255     


Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Asn Trp 
            260                 265                 270         


Ser His Pro Gln Phe Glu Lys Gly Ser Gly Gly Gly Gly Ser Ala Gly 
        275                 280                 285             


Gly Gln Val Glu Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser 
    290                 295                 300                 


Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr 
305                 310                 315                 320 


Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu 
                325                 330                 335     


Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro 
            340                 345                 350         


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln 
        355                 360                 365             


Val Phe Leu Lys Ile Thr Gly Val Asp Thr Ala Asp Thr Ala Thr Tyr 
    370                 375                 380                 


Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly 
385                 390                 395                 400 


Ala Gly Thr Thr Val Thr Val Ser Ser 
                405                 


<210>  145
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 light chain coding sequence

<400>  145
atggctaccg gcagcagaac aagcctgctg ctcgcttttg gactgctctg tctcccctgg       60

ttgcaagaag gcagcgccga aattgtgttg acacagtctc caggcaccct gtctttgtct      120

ccaggggaaa cagccatcat ctcttgtcgg accagtcagt atggttcctt agcctggtat      180

caacagaggc ccggccaggc ccccaggctc gtcatctatt cgggctctac tcgggccgct      240

ggcatcccag acaggttcag cggcagtcgg tgggggccag actacaatct caccatcagc      300

aacctggagt cgggagattt tggtgtttat tattgccagc agtatgaatt ttttggccag      360

gggaccaagg tccaggtcga cattaagcgc actgtggccg ctcctagcgt gttcatcttt      420

ccacctagcg acgagcagct gaagtctggc actgcctctg tcgtgtgcct gctgaacaac      480

ttctaccctc gagaggccaa ggtgcagtgg aaagtggaca atgccctgca gagcggcaac      540

agccaagagt ctgtgaccga gcaggactcc aaggattcca cctacagcct gtctagcacc      600

ctgactctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacacac      660

cagggactga gcagccctgt gaccaagagc ttcaatcggg gcgagtgc                   708


<210>  146
<211>  312
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 variable light chain coding sequence

<400>  146
gaaattgtgt tgacacagtc tccaggcacc ctgtctttgt ctccagggga aacagccatc       60

atctcttgtc ggaccagtca gtatggttcc ttagcctggt atcaacagag gcccggccag      120

gcccccaggc tcgtcatcta ttcgggctct actcgggccg ctggcatccc agacaggttc      180

agcggcagtc ggtgggggcc agactacaat ctcaccatca gcaacctgga gtcgggagat      240

tttggtgttt attattgcca gcagtatgaa ttttttggcc aggggaccaa ggtccaggtc      300

gacattaagc gc                                                          312


<210>  147
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 variable heavy chain coding sequence

<400>  147
caggtgcagc tggtgcagtc tgggggtcag atgaagaagc ctggcgagtc gatgagaatt       60

tcttgtcggg cttctggata tgaatttatt gattgtacgc taaattggat tcgtctggcc      120

cccggaaaaa ggcctgagtg gatgggatgg ctgaagcctc gaggtggcgc ggtcaactac      180

gcacgtccac ttcagggcag agtgaccatg actcgagacg tttattccga cacagccttt      240

ttggagctgc gctcgttgac agtagacgac acggccgtct acttttgtac taggggaaaa      300

aactgtgatt acaattggga cttcgaacac tggggccggg gcaccccggt catcgtctca      360

tca                                                                    363


<210>  148
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 light chain amino acid sequence

<400>  148

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Glu Ile Val Leu Thr Gln 
            20                  25                  30          


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser 
        35                  40                  45              


Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala 
65                  70                  75                  80  


Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  149
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 variable light chain amino acid sequence

<400>  149

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  150
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 variable heavy chain amino acid sequence

<400>  150

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  151
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  splice junction with flanking sequence in constructs of the 
       disclosure

<400>  151
caggtgagtt ggctttcctt ctgcctcctt tctctgggcc cagcgtcctc tgacctggag       60

ctgggagata atgtccgggg gctcctt                                           87


<210>  152
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in Hu-emAb-VRC01-AAV

<400>  152

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Glu Ile Val Leu Thr Gln 
            20                  25                  30          


Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Thr Ala Ile Ile Ser 
        35                  40                  45              


Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala Trp Tyr Gln Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser Gly Ser Thr Arg Ala Ala 
65                  70                  75                  80  


Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg Trp Gly Pro Asp Tyr Asn 
                85                  90                  95      


Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp Phe Gly Val Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr Lys Val Gln Val Asp Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
                245                 250                 255     


Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ala Gly Gly Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met 
    290                 295                 300                 


Lys Lys Pro Gly Glu Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr 
305                 310                 315                 320 


Glu Phe Ile Asp Cys Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys 
                325                 330                 335     


Arg Pro Glu Trp Met Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn 
            340                 345                 350         


Tyr Ala Arg Pro Leu Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr 
        355                 360                 365             


Ser Asp Thr Ala Phe Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr 
    370                 375                 380                 


Ala Val Tyr Phe Cys Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp 
385                 390                 395                 400 


Phe Glu His Trp Gly Arg Gly Thr Pro Val Ile Val Ser Ser 
                405                 410                 


<210>  153
<211>  430
<212>  DNA
<213>  Homo sapiens

<400>  153
tgtgacgccc ggagacagaa ggtctctggg tggctgggtt tttgtggggt gaggatggac       60

attctgccat tgtgattact actactacta ctacatggac gtctggggca aagggaccac      120

ggtcaccgtc tcctcaggta agaatggcca ctctagggcc tttgttttct gctactgcct      180

gtggggtttc ctgagggcat gttccgaggg gacctgggcg gactggccag gaggggatgg      240

gcactggggt gccttgagga tctgggagcc tctgtggatt ttccgatgcc tttggaaaat      300

gggactcagg ttgggtgcgt ctgatggagt aactgagcct gggggcttgg ggagccacat      360

ttggacgaga tgcctgaaca aaccaggggt cttagtgatg gctgaggaat gtgtctcagg      420

agcggtgtct                                                             430


<210>  154
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Medi8852 light chain coding sequence

<400>  154
atggctaccg gcagcagaac aagcctgctg ctcgcttttg gactgctctg tctcccctgg       60

ttgcaagaag gcagcgccga tattcagatg acccagagcc cttccagcct gtccgcttca      120

gtgggggatc gagtgaccat tacctgccga accagccaga gcctgagctc ctacacgcac      180

tggtatcagc agaagcccgg caaagcccct aagctgctga tctacgccgc ttctagtcgg      240

gggtccggag tgccaagccg gttctccgga tctgggagtg gaaccgactt taccctgaca      300

atttcaagcc tgcagcccga ggatttcgct acatactact gtcagcagag cagaactttc      360

gggcagggca ctaaggtgga gatcaaacgg actgtggccg ctcctagcgt gttcatcttt      420

ccacctagcg acgagcagct gaagtctggc actgcctctg tcgtgtgcct gctgaacaac      480

ttctaccctc gagaggccaa ggtgcagtgg aaagtggaca atgccctgca gagcggcaac      540

agccaagagt ctgtgaccga gcaggactcc aaggattcca cctacagcct gtctagcacc      600

ctgactctga gcaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacacac      660

cagggactga gcagccctgt gaccaagagc ttcaatcggg gcgagtgc                   708


<210>  155
<211>  309
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEDI8852-VK anti-stem HA variable light chain coding sequence

<400>  155
gatattcaga tgacccagag cccttccagc ctgtccgctt cagtggggga tcgagtgacc       60

attacctgcc gaaccagcca gagcctgagc tcctacacgc actggtatca gcagaagccc      120

ggcaaagccc ctaagctgct gatctacgcc gcttctagtc gggggtccgg agtgccaagc      180

cggttctccg gatctgggag tggaaccgac tttaccctga caatttcaag cctgcagccc      240

gaggatttcg ctacatacta ctgtcagcag agcagaactt tcgggcaggg cactaaggtg      300

gagatcaaa                                                              309


<210>  156
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-stem HA variable heavy chain coding sequence

<400>  156
caggtccagc tgcagcagag cggccccgga ctggtcaagc cttcacagac actgagcctg       60

acatgcgcca ttagcggaga tagcgtgagc tcctacaatg ccgtgtggaa ctggatcagg      120

cagtctccaa gtcgaggact ggagtggctg ggacgaacat actatagatc cgggtggtac      180

aatgactatg ctgaatcagt gaaaagccga attactatca accccgatac ctccaagaat      240

cagttctctc tgcagctgaa cagtgtgacc cctgaggaca cagccgtgta ctactgcgcc      300

agaagcggcc atatcaccgt ctttggcgtc aatgtggatg ctttcgatat gtgggggcag      360

gggactatgg tcaccgtctc ttca                                             384


<210>  157
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Medi8852 light chain amino acid sequence

<400>  157

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr Thr His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Arg 
65                  70                  75                  80  


Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  158
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MEDI8852-VK anti-stem HA variable light chain amino acid sequence

<400>  158

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr 
            20                  25                  30          


Thr His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Arg Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  159
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-stem HA variable heavy chain amino acid sequence

<400>  159

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Tyr 
            20                  25                  30          


Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Gly Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val Phe Gly Val Asn Val 
            100                 105                 110         


Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125             


<210>  160
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in  hu-emAb-Medi8852-AAV

<400>  160

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr Thr His Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Arg 
65                  70                  75                  80  


Gly Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Ser 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly 
                245                 250                 255     


Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Ala Gly Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu 
    290                 295                 300                 


Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp 
305                 310                 315                 320 


Ser Val Ser Ser Tyr Asn Ala Val Trp Asn Trp Ile Arg Gln Ser Pro 
                325                 330                 335     


Ser Arg Gly Leu Glu Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Gly Trp 
            340                 345                 350         


Tyr Asn Asp Tyr Ala Glu Ser Val Lys Ser Arg Ile Thr Ile Asn Pro 
        355                 360                 365             


Asp Thr Ser Lys Asn Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly His Ile Thr Val 
385                 390                 395                 400 


Phe Gly Val Asn Val Asp Ala Phe Asp Met Trp Gly Gln Gly Thr Met 
                405                 410                 415     


Val Thr Val Ser Ser 
            420     


<210>  161
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AMM01 light chain coding sequence

<400>  161
atggctaccg gcagcagaac aagcctgctg ctcgcttttg gactgctctg tctcccctgg       60

ttgcaagaag gcagcgcctc ctatgagctg actcagccac cctcagtgtc agtggccccg      120

gggcagaggg ccacaattac ctgtggggga cacaacatcg gagctaaaaa tgtccactgg      180

taccagcaga agccaggcca ggcccctgtc ctggtcatcc aatatgatag cgaccggccc      240

tcagggatcc ctgagcgatt ctctggctcc aactctggga gcacggccac cctgaccatc      300

agcagggtcg aagccgggga tgaggccgac tattactgtc aggtgtggga tagtggtcgt      360

gggcatcccc tttatgtctt cggaggtggg accaaggtca ccgtcctagg tcagcccaag      420

gccaacccca ctgtcactct gttcccaccc tcgagtgagg agcttcaagc caacaaggcc      480

acactggtgt gtctcataag tgacttctac ccgggagccg tgacagtggc ctggaaggca      540

gatagcagcc ccgtcaaggc gggagtggag accaccacac cctccaaaca aagcaacaac      600

aagtacgcgg ccagcagcta cctgagcctg acgcctgagc agtggaagtc ccacagaagc      660

tacagctgcc aggtcacgca tgaagggagc accgtggaga agacagtggc ccctacagaa      720

tgttca                                                                 726


<210>  162
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AMM01 lambda variable light chain coding sequence

<400>  162
tcctatgagc tgactcagcc accctcagtg tcagtggccc cggggcagag ggccacaatt       60

acctgtgggg gacacaacat cggagctaaa aatgtccact ggtaccagca gaagccaggc      120

caggcccctg tcctggtcat ccaatatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gagcacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtggtc gtgggcatcc cctttatgtc      300

ttcggaggtg ggaccaaggt caccgtccta ggtcagccca aggccaaccc cactgtcact      360

ctgttcccac cc                                                          372


<210>  163
<211>  276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  lambda constant light chain coding sequence

<400>  163
tcgagtgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac       60

ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag      120

accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta cctgagcctg      180

acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc      240

accgtggaga agacagtggc ccctacagaa tgttca                                276


<210>  164
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AMM01 variable heavy chain coding sequence

<400>  164
caggttcagc tggtgcagtc tggagctgat gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggtta cacctttatt cattttggta tcagttgggt gcggcaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcgacacta ataatggtaa cacaaactat      180

gcacagagtc tccagggcag agtcaccatg accacagata catccacggg cacagcctac      240

atggagctga ggagcctctc gactgacgac acggccgtgt atttctgtgc gcgagctctg      300

gaaatggggc atagaagtgg cttcccattt gactactggg gccagggagt cctggtcacc      360

gtctcccca                                                              369


<210>  165
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMM01 light chain amino acid sequence

<400>  165

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Tyr Glu Leu Thr Gln 
            20                  25                  30          


Pro Pro Ser Val Ser Val Ala Pro Gly Gln Arg Ala Thr Ile Thr Cys 
        35                  40                  45              


Gly Gly His Asn Ile Gly Ala Lys Asn Val His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Val Leu Val Ile Gln Tyr Asp Ser Asp Arg Pro 
65                  70                  75                  80  


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Ser Thr Ala 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 
            100                 105                 110         


Cys Gln Val Trp Asp Ser Gly Arg Gly His Pro Leu Tyr Val Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr 
    130                 135                 140                 


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
                165                 170                 175     


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
            180                 185                 190         


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
        195                 200                 205             


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
    210                 215                 220                 


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
225                 230                 235                 240 


Cys Ser 
        


<210>  166
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMM01 variable light chain amino acid sequence

<400>  166

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Thr Cys Gly Gly His Asn Ile Gly Ala Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Gln 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Arg Gly His 
                85                  90                  95      


Pro Leu Tyr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro 
        115                 120                 


<210>  167
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMM01 lambda constant light chain amino acid sequence

<400>  167

Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile 
1               5                   10                  15      


Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser 
            20                  25                  30          


Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser 
        35                  40                  45              


Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln 
    50                  55                  60                  


Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser 
65                  70                  75                  80  


Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
                85                  90          


<210>  168
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMM01 variable heavy chain amino acid sequence

<400>  168

Gln Val Gln Leu Val Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile His Phe 
            20                  25                  30          


Gly Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Thr Asn Asn Gly Asn Thr Asn Tyr Ala Gln Ser Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ser Thr Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Leu Glu Met Gly His Arg Ser Gly Phe Pro Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Val Leu Val Thr Val Ser Pro 
        115                 120             


<210>  169
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in  hu-emAb-AMM01-AAV

<400>  169

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Ser Tyr Glu Leu Thr Gln 
            20                  25                  30          


Pro Pro Ser Val Ser Val Ala Pro Gly Gln Arg Ala Thr Ile Thr Cys 
        35                  40                  45              


Gly Gly His Asn Ile Gly Ala Lys Asn Val His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ala Pro Val Leu Val Ile Gln Tyr Asp Ser Asp Arg Pro 
65                  70                  75                  80  


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Ser Thr Ala 
                85                  90                  95      


Thr Leu Thr Ile Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr 
            100                 105                 110         


Cys Gln Val Trp Asp Ser Gly Arg Gly His Pro Leu Tyr Val Phe Gly 
        115                 120                 125             


Gly Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr 
    130                 135                 140                 


Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val 
                165                 170                 175     


Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr 
            180                 185                 190         


Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu 
        195                 200                 205             


Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln 
    210                 215                 220                 


Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu 
225                 230                 235                 240 


Cys Ser Gly Gly Ser Ser Gly Ser Gly Ser Gly Ser Asn Trp Ser His 
                245                 250                 255     


Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln 
            260                 265                 270         


Phe Glu Lys Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu 
        275                 280                 285             


Lys Gly Ser Gly Gly Gly Gly Ser Ala Gly Gly Gln Val Gln Leu Val 
    290                 295                 300                 


Gln Ser Gly Ala Asp Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
305                 310                 315                 320 


Cys Lys Ala Ser Gly Tyr Thr Phe Ile His Phe Gly Ile Ser Trp Val 
                325                 330                 335     


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Asp Thr 
            340                 345                 350         


Asn Asn Gly Asn Thr Asn Tyr Ala Gln Ser Leu Gln Gly Arg Val Thr 
        355                 360                 365             


Met Thr Thr Asp Thr Ser Thr Gly Thr Ala Tyr Met Glu Leu Arg Ser 
    370                 375                 380                 


Leu Ser Thr Asp Asp Thr Ala Val Tyr Phe Cys Ala Arg Ala Leu Glu 
385                 390                 395                 400 


Met Gly His Arg Ser Gly Phe Pro Phe Asp Tyr Trp Gly Gln Gly Val 
                405                 410                 415     


Leu Val Thr Val Ser Pro 
            420         


<210>  170
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  170
aggaccacct ctgtgacagc atttatacag tatccgatg                              39


<210>  171
<211>  41
<212>  DNA
<213>  Mus musculus

<400>  171
catagggaca aagagtggag tggggcactt tctttagatt t                           41


<210>  172
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in Balb/C mRSV-Splice Integration

<400>  172

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser 
        35                  40                  45              


Val Gly Tyr Met His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys 
    50                  55                  60                  


Leu Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Ile Gln Ala Glu Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly 
            100                 105                 110         


Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Asp 
        115                 120                 125             


Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr 
    130                 135                 140                 


Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys 
145                 150                 155                 160 


Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly 
                165                 170                 175     


Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn 
        195                 200                 205             


Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val 
    210                 215                 220                 


Lys Ser Phe Asn Arg Asn Glu Cys Gly Gly Ser Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser 
                245                 250                 255     


Asn Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Gly Ser Asn Trp 
            260                 265                 270         


Ser His Pro Gln Phe Glu Lys Gly Ser Gly Gly Gly Gly Ser Ala Gly 
        275                 280                 285             


Gly Gln Val Glu Leu Gln Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser 
    290                 295                 300                 


Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr 
305                 310                 315                 320 


Ser Gly Met Ser Val Gly Trp Ile Arg Gln Pro Ser Gly Glu Gly Leu 
                325                 330                 335     


Glu Trp Leu Ala Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro 
            340                 345                 350         


Ser Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln 
        355                 360                 365             


Val Phe Leu Lys Ile Thr Gly Val Asp Thr Ala Asp Thr Ala Thr Tyr 
    370                 375                 380                 


Tyr Cys Ala Arg Ser Met Ile Thr Asn Trp Tyr Phe Asp Val Trp Gly 
385                 390                 395                 400 


Ala Gly Thr Thr Val Thr Val Ser Ser 
                405                 


<210>  173
<211>  41
<212>  DNA
<213>  Homo sapiens

<400>  173
gtcttagtga tggctgagga atgtgtctca ggagcggtgt c                           41


<210>  174
<211>  41
<212>  DNA
<213>  Homo sapiens

<400>  174
tgtaggactg caagatcgct gcacagcagc gaatcgtgaa a                           41


<210>  175
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide-light chain-streptag linker-variable heavy chain 
       amino acid sequence in  TT-hRSV-T7-integrated

<400>  175

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Lys Cys Gln Leu Ser Val Gly Tyr Met His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Lys Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly 
225                 230                 235                 240 


Gly Ser Ser Gly Ser Gly Ser Gly Ser Asn Trp Ser His Pro Gln Phe 
                245                 250                 255     


Glu Lys Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys 
            260                 265                 270         


Gly Gly Gly Gly Ser Asn Trp Ser His Pro Gln Phe Glu Lys Gly Ser 
        275                 280                 285             


Gly Gly Gly Gly Ser Ala Gly Gly Gln Val Thr Leu Arg Glu Ser Gly 
    290                 295                 300                 


Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe 
305                 310                 315                 320 


Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Ser Val Gly Trp Ile Arg 
                325                 330                 335     


Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Asp Ile Trp Trp Asp 
            340                 345                 350         


Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Ser 
        355                 360                 365             


Lys Asp Thr Ser Lys Asn Gln Val Val Leu Lys Val Thr Asn Met Asp 
    370                 375                 380                 


Pro Ala Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Ser Met Ile Thr Asn 
385                 390                 395                 400 


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Thr Val Ser Ser 
                405                 410                 415 


<210>  176
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T2A self-cleaving peptide

<400>  176

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  177
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A self-cleaving peptide

<400>  177

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  178
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E2A self-cleaving peptide

<400>  178

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro Pro 
            20                  


<210>  179
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A self-cleaving peptide

<400>  179

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  180
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly-Ser linker


<220>
<221>  MISC_FEATURE
<223>  Gly-Ser linker (GGS)n, where n=1 to 100

<400>  180

Gly Gly Ser 
1           


<210>  181
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly-Ser linker


<220>
<221>  MISC_FEATURE
<223>  Gly-Ser linker (GGGS)n, where n=1 to 100

<400>  181

Gly Gly Gly Ser 
1               


<210>  182
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gly-Ser linker


<220>
<221>  MISC_FEATURE
<223>  Gly-Ser linker (GGGGS)n, where n=1 to 100

<400>  182

Gly Gly Gly Gly Ser 
1               5   


<210>  183
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<223>  linker (KESGSVSSEQLAQFRSLD)n, where n=1 to 100

<400>  183

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  184
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker


<220>
<221>  MISC_FEATURE
<223>  linker (EGKSSGSGSESKST)n, where n=1 to 100

<400>  184

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  185
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  185

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  186
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  186

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  187
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  187

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  188
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  188

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  189
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  189

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  190
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  190

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  191
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  191

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  192
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgH heavy chains

<400>  192

Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      


Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      


<210>  193
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgL light chains

<400>  193

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  194
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary signal peptide derived from human IgL light chains

<400>  194

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  195
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep tag II

<400>  195

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  196

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Xpress tag

<400>  197

Asp Leu Tyr Asp Asp Asp Asp Lys 
1               5               


<210>  198
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avi tag

<400>  198

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  199
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  calmodulin tag

<400>  199

Lys Arg Arg Trp Lys Lys Asn Phe Ile Ala Val Ser Ala Ala Asn Arg 
1               5                   10                  15      


Phe Lys Lys Ile Ser Ser Ser Gly Ala Leu 
            20                  25      


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA tag

<400>  200

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  201
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc tag

<400>  201

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  202
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 1

<400>  202

Ser Leu Ala Glu Leu Leu Asn Ala Gly Leu Gly Gly Ser 
1               5                   10              


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Softag 3

<400>  203

Thr Gln Asp Pro Ser Arg Val Gly 
1               5               


<210>  204
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag

<400>  204

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  205
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain amino acid sequence of exemplary mouse 
       palivizumab

<400>  205

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Leu Ser Thr Ser Pro Lys Leu Gln Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Ile Gln Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  206
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain amino acid sequence of exemplary human 
       anti-RSV antibody

<400>  206

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105     


<210>  207
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary anti-RSV antibody

<400>  207

Gly Ala Ser Ile Asn Ser Asp Asn Tyr Tyr Trp Thr 
1               5                   10          


<210>  208
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary anti-RSV antibody

<400>  208

His Ile Ser Tyr Thr Gly Asn Thr Tyr Tyr Thr Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  209
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary anti-RSV antibody

<400>  209

Cys Gly Ala Tyr Val Leu Ile Ser Asn Cys Gly Trp Phe Asp Ser 
1               5                   10                  15  


<210>  210
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary anti-RSV antibody

<400>  210

Gln Ala Ser Gln Asp Ile Ser Thr Tyr Leu Asn 
1               5                   10      


<210>  211
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary anti-RSV antibody

<400>  211

Gly Ala Ser Asn Leu Glu Thr 
1               5           


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary anti-RSV antibody

<400>  212

Gln Gln Tyr Gln Tyr Leu Pro Tyr Thr 
1               5                   


<210>  213
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary 10E8 anti-HIV antibody

<400>  213

Gly Phe Asp Phe Asp Asn Ala Trp 
1               5               


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary 10E8 anti-HIV antibody

<400>  214

Ile Thr Gly Pro Gly Glu Gly Trp Ser Val 
1               5                   10  


<210>  215
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary 10E8 anti-HIV antibody

<400>  215

Thr Gly Lys Tyr Tyr Asp Phe Trp Ser Gly Tyr Pro Pro Gly Glu Glu 
1               5                   10                  15      


Tyr Phe Gln Asp 
            20  


<210>  216
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary 10E8 anti-HIV antibody

<400>  216

Thr Gly Asp Ser Leu Arg Ser His Tyr Ala Ser 
1               5                   10      


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary 10E8 anti-HIV antibody

<400>  217

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  218
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary 10E8 anti-HIV antibody

<400>  218

Ser Ser Arg Asp Lys Ser Gly Ser Arg Leu Ser Val 
1               5                   10          


<210>  219
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary VRC01 anti-HIV antibody

<400>  219

Gly Tyr Glu Phe Ile Asp Cys Thr 
1               5               


<210>  220
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary VRC01 anti-HIV antibody

<400>  220

Lys Pro Arg Gly Gly Ala Val Asn 
1               5               


<210>  221
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary VRC01 anti-HIV antibody

<400>  221

Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp 
1               5                   10                  


<210>  222
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary VRC01 anti-HIV antibody

<400>  222

Gln Gln Tyr Glu Phe 
1               5   


<210>  223
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary  anti-Dengue virus antibody

<400>  223

Glu Val Gln Leu His Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys 
            20                  25                  30  


<210>  224
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary  anti-Dengue virus antibody

<400>  224

Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
1               5                   10              


<210>  225
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary  anti-Dengue virus antibody

<400>  225

Ala Thr Ile Lys Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu 
1               5                   10                  15      


Ile Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Phe 
            20                  25                  30      


<210>  226
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary  anti-Dengue virus antibody

<400>  226

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys 
            20              


<210>  227
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary  anti-Dengue virus antibody

<400>  227

Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr 
1               5                   10                  15  


<210>  228
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary  anti-Dengue virus antibody

<400>  228

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser 
1               5                   10                  15      


Leu Lys Ile Asn Ser Leu Gln Ser Glu Asp Phe Gly Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  229
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary  anti-Dengue virus antibody

<400>  229

Tyr Thr Phe Thr Asp Tyr Ala Ile Thr 
1               5                   


<210>  230
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary  anti-Dengue virus antibody

<400>  230

Gly Leu Ile Ser Thr Tyr Tyr Gly Asp Ser Phe Tyr Asn Gln Lys Phe 
1               5                   10                  15      


Lys Gly 
        


<210>  231
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary  anti-Dengue virus antibody

<400>  231

Thr Ile Arg Asp Gly Lys Ala Met Asp Tyr 
1               5                   10  


<210>  232
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary  anti-Dengue virus antibody

<400>  232

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  233
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary  anti-Dengue virus antibody

<400>  233

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  234
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary  anti-Dengue virus antibody

<400>  234

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  235
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable heavy chain of exemplary pertussis antibody

<400>  235

Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Lys Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Phe Pro Gly Ser Gly Ser Thr Asn Tyr Asp Glu Lys Phe 
    50                  55                  60                  


Asn Ser Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Leu Ser Gly Ala Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  236
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable light chain of exemplary pertussis antibody

<400>  236

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Pro Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Pro Pro Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary anti-hepatitis C antibody

<400>  237

Ser Tyr Gly Met His Trp 
1               5       


<210>  238
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary anti-hepatitis C antibody

<400>  238

Val Ile Trp Leu Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  239
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary anti-hepatitis C antibody

<400>  239

Ala Arg Asp Ile Phe Thr Val Ala Arg Gly Val Ile Ile Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  240
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary anti-hepatitis C antibody

<400>  240

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary anti-hepatitis C antibody

<400>  241

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  242
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary anti-hepatitis C antibody

<400>  242

Gln Gln Arg Ser Asn Trp Val Thr 
1               5               


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary anti-influenza virus antibody

<400>  243

Gly Met Thr Ser Asn Ser Leu Ala 
1               5               


<210>  244
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary anti-influenza virus antibody

<400>  244

Ile Ile Pro Val Phe Glu Thr Pro 
1               5               


<210>  245
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary anti-influenza virus antibody

<400>  245

Ala Thr Ser Ala Gly Gly Ile Val Asn Tyr Tyr Leu Ser Phe Asn Ile 
1               5                   10                  15      


<210>  246
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary anti-influenza virus antibody

<400>  246

Gln Thr Ile Thr Thr Trp 
1               5       


<210>  247
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary anti-influenza virus antibody

<400>  247

Gln Gln Tyr Ser Thr Tyr Ser Gly Thr 
1               5                   


<210>  248
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary anti-EBV AMM01 antibody

<400>  248

Tyr Thr Phe Ile His Phe Gly Ile Ser Trp 
1               5                   10  


<210>  249
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary anti-EBV AMM01 antibody

<400>  249

Ile Asp Thr Asn Asn Gly Asn Thr Asn Tyr Ala Gln Ser Leu Gln Gly 
1               5                   10                  15      


<210>  250
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary anti-EBV AMM01 antibody

<400>  250

Arg Ala Leu Glu Met Gly His Arg Ser Gly Phe Pro Phe Asp Tyr 
1               5                   10                  15  


<210>  251
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary anti-EBV AMM01 antibody

<400>  251

Gly Gly His Asn Ile Gly Ala Lys Asn Val His 
1               5                   10      


<210>  252
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary anti-EBV AMM01 antibody

<400>  252

Tyr Asp Ser Asp Arg Pro Ser 
1               5           


<210>  253
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary anti-EBV AMM01 antibody

<400>  253

Cys Gln Val Trp Asp Ser Gly Arg Gly His Pro Leu Tyr Val 
1               5                   10                  


<210>  254
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beginning of heavy chain of infliximab

<400>  254

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys 
            


<210>  255
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beginning of light chain of infliximab

<400>  255

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg 
        


<210>  256
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary infliximab

<400>  256

Ile Phe Ser Asn His Trp 
1               5       


<210>  257
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary infliximab

<400>  257

Arg Ser Lys Ser Ile Asn Ser Ala Thr His 
1               5                   10  


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary infliximab

<400>  258

Asn Tyr Tyr Gly Ser Thr Tyr 
1               5           


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary infliximab

<400>  259

Phe Val Gly Ser Ser Ile His 
1               5           


<210>  260
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary infliximab

<400>  260

Lys Tyr Ala Ser Glu Ser Met 
1               5           


<210>  261
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary infliximab

<400>  261

Gln Ser His Ser Trp 
1               5   


<210>  262
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary adalimumab

<400>  262

Thr Phe Asp Asp Tyr Ala 
1               5       


<210>  263
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary adalimumab

<400>  263

Thr Trp Asn Ser Gly His Ile Asp 
1               5               


<210>  264
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary adalimumab

<400>  264

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
1               5                   10  


<210>  265
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary adalimumab

<400>  265

Gly Ile Arg Asn Tyr Leu Ala 
1               5           


<210>  266
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary adalimumab

<400>  266

Tyr Ala Ala Ser Thr Leu Gln 
1               5           


<210>  267
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary adalimumab

<400>  267

Arg Tyr Asn Arg Ala 
1               5   


<210>  268
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1 of exemplary certolizumab

<400>  268

Val Phe Thr Asp Tyr Gly 
1               5       


<210>  269
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2 of exemplary certolizumab

<400>  269

Asn Thr Tyr Ile Gly Glu Pro Ile 
1               5               


<210>  270
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 of exemplary certolizumab

<400>  270

Gly Tyr Arg Ser Tyr Ala Met 
1               5           


<210>  271
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1 of exemplary certolizumab

<400>  271

Asn Val Gly Thr Asn Val Ala 
1               5           


<210>  272
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2 of exemplary certolizumab

<400>  272

Tyr Ser Ala Ser Phe Leu Tyr 
1               5           


<210>  273
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3 of exemplary certolizumab

<400>  273

Gln Tyr Asn Ile Tyr 
1               5   


<210>  274
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse forward oligo for amplification of region flanking cut site

<400>  274
ggctccacca gacctctcta                                                   20


<210>  275
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse reverse oligo for amplification of region flanking cut site

<400>  275
aacctcagtc accgtctcct                                                   20


<210>  276
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human forward oligo for amplification of region flanking cut site

<400>  276
acagtaagca tgcctcctaa g                                                 21


<210>  277
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  human reverse oligo for amplification of region flanking cut site

<400>  277
gccactctag ggcctttgtt                                                   20


<210>  278
<211>  65
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse forward primer to amplify anti-RSV-emAb template

<400>  278
accacctctg tgacagcatt tatacagtat ccgatggaca agtgagtgtc tcaggttagg       60

attct                                                                   65


<210>  279
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mouse reverse primer to amplify anti-RSV-emAb template

<400>  279
taaagaaagt gccccactcc actctttgtc cctatgcttg accacaatga atactcccac       60

c                                                                       61


<210>  280
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hRSV light chain coding sequence without signal sequence in human
       anti-RSV emAb AAV

<400>  280
gacatccaga tgacacagag ccctagcaca ctgtctgcca gcgtgggcga cagagtgacc       60

atcacatgca agtgccagct gagcgtgggc tacatgcact ggtatcagca aaagcccggc      120

aaggccccta agctgctgat ctacgatacc tccaagctgg cctctggcgt gccctccaga      180

ttttctggca gcggcagcgg aaccgagttc accctgacca tctcaagcct gcagcctgac      240

gacttcgcta cgtactactg cttccaaggc agcggctacc ccttcacatt tggcggcgga      300

acaaagctgg aaatcaagcg gactgtggcc gctcctagcg tgttcatctt tccacctagc      360

gacgagcagc tgaagtctgg cactgcctct gtcgtgtgcc tgctgaacaa cttctaccct      420

cgagaggcca aggtgcagtg gaaagtggac aatgccctgc agagcggcaa cagccaagag      480

tctgtgaccg agcaggactc caaggattcc acctacagcc tgtctagcac cctgactctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgacaca ccagggactg      600

agcagccctg tgaccaagag cttcaatcgg ggcgagtgc                             639


<210>  281
<211>  636
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRSV kappa light chain coding sequence without signal sequence in
       mouse anti-RSV emAb AAV

<400>  281
gacatccagc tgacacagag ccctgccatc atgtctgcta gccctggcga gaaagtgaca       60

atgacctgtt ccgccagcag ctccgtgggc tacatgcact ggtatcagca gaagtctagc      120

acaagcccca agctgtggat ctacgacacc tccaagctgg cctctggcgt gccaggcaga      180

ttttctggaa gcggcagcgg caacagctac agcctgacta tcagctccat ccaggccgag      240

gatgtggcta cctactactg cttcagaggc agcggctacc ccttcacatt tggccagggc      300

accaagctgg aaatcaaggc cgatgccgct cctaccgtgt ctatctttcc acctagcagc      360

gagcagctga catctggcgg agcctctgtc gtgtgcttcc tgaacaactt ctaccctaag      420

gacatcaacg tcaagtggaa gatcgacggc tccgagagac agaacggcgt gctgaactct      480

tggaccgacc aggacagcaa ggatagcacc tacagcatga gcagcactct gaccctgaca      540

aaggacgagt acgagaggca caactcctac acatgcgagg ccacacacaa gaccagcaca      600

tccccaatcg tgaagtcctt caaccggaac gagtgc                                636


<210>  282
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VRC01 light chain coding sequence without signal sequence in 
       Hu-emAb-VRC01-AAV

<400>  282
gaaattgtgt tgacacagtc tccaggcacc ctgtctttgt ctccagggga aacagccatc       60

atctcttgtc ggaccagtca gtatggttcc ttagcctggt atcaacagag gcccggccag      120

gcccccaggc tcgtcatcta ttcgggctct actcgggccg ctggcatccc agacaggttc      180

agcggcagtc ggtgggggcc agactacaat ctcaccatca gcaacctgga gtcgggagat      240

tttggtgttt attattgcca gcagtatgaa ttttttggcc aggggaccaa ggtccaggtc      300

gacattaagc gcactgtggc cgctcctagc gtgttcatct ttccacctag cgacgagcag      360

ctgaagtctg gcactgcctc tgtcgtgtgc ctgctgaaca acttctaccc tcgagaggcc      420

aaggtgcagt ggaaagtgga caatgccctg cagagcggca acagccaaga gtctgtgacc      480

gagcaggact ccaaggattc cacctacagc ctgtctagca ccctgactct gagcaaggcc      540

gactacgaga agcacaaggt gtacgcctgc gaagtgacac accagggact gagcagccct      600

gtgaccaaga gcttcaatcg gggcgagtgc                                       630


<210>  283
<211>  630
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Medi8852 light chain coding sequence without signal sequence in 
       hu-emAb-Medi8852-AAV

<400>  283
gatattcaga tgacccagag cccttccagc ctgtccgctt cagtggggga tcgagtgacc       60

attacctgcc gaaccagcca gagcctgagc tcctacacgc actggtatca gcagaagccc      120

ggcaaagccc ctaagctgct gatctacgcc gcttctagtc gggggtccgg agtgccaagc      180

cggttctccg gatctgggag tggaaccgac tttaccctga caatttcaag cctgcagccc      240

gaggatttcg ctacatacta ctgtcagcag agcagaactt tcgggcaggg cactaaggtg      300

gagatcaaac ggactgtggc cgctcctagc gtgttcatct ttccacctag cgacgagcag      360

ctgaagtctg gcactgcctc tgtcgtgtgc ctgctgaaca acttctaccc tcgagaggcc      420

aaggtgcagt ggaaagtgga caatgccctg cagagcggca acagccaaga gtctgtgacc      480

gagcaggact ccaaggattc cacctacagc ctgtctagca ccctgactct gagcaaggcc      540

gactacgaga agcacaaggt gtacgcctgc gaagtgacac accagggact gagcagccct      600

gtgaccaaga gcttcaatcg gggcgagtgc                                       630


<210>  284
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AMM01 light chain coding sequence without signal sequence in 
       hu-emAb-AMM01-AAV

<400>  284
tcctatgagc tgactcagcc accctcagtg tcagtggccc cggggcagag ggccacaatt       60

acctgtgggg gacacaacat cggagctaaa aatgtccact ggtaccagca gaagccaggc      120

caggcccctg tcctggtcat ccaatatgat agcgaccggc cctcagggat ccctgagcga      180

ttctctggct ccaactctgg gagcacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtggtc gtgggcatcc cctttatgtc      300

ttcggaggtg ggaccaaggt caccgtccta ggtcagccca aggccaaccc cactgtcact      360

ctgttcccac cctcgagtga ggagcttcaa gccaacaagg ccacactggt gtgtctcata      420

agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag      480

gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc      540

tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg      600

catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca                   648


<210>  285
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hRSV light chain amino acid sequence without signal peptide in 
       human anti-RSV emAb AAV

<400>  285

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Cys Gln Leu Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  286
<211>  212
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mRSV kappa light chain amino acid sequence without signal peptide
       in mouse anti-RSV emAb AAV

<400>  286

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Gly Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Ile Gln Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Arg Gly Ser Gly Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ala Asp Ala Ala Pro Thr 
            100                 105                 110         


Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala 
        115                 120                 125             


Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val 
    130                 135                 140                 


Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser 
145                 150                 155                 160 


Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr 
                165                 170                 175     


Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys 
            180                 185                 190         


Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn 
        195                 200                 205             


Arg Asn Glu Cys 
    210         


<210>  287
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRC01 light chain amino acid sequence without signal peptide in 
       Hu-emAb-VRC01-AAV

<400>  287

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                165                 170                 175     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            180                 185                 190         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        195                 200                 205             


Glu Cys 
    210 


<210>  288
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Medi8852 light chain amino acid sequence without signal peptide 
       in hu-emAb-Medi8852-AAV

<400>  288

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Leu Ser Ser Tyr 
            20                  25                  30          


Thr His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Arg Gly Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Arg Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                165                 170                 175     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            180                 185                 190         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        195                 200                 205             


Glu Cys 
    210 


<210>  289
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AMM01 light chain amino acid sequence without signal peptide in 
       hu-emAb-AMM01-AAV

<400>  289

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Arg Ala Thr Ile Thr Cys Gly Gly His Asn Ile Gly Ala Lys Asn Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Gln 
        35                  40                  45              


Tyr Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Arg Gly His 
                85                  90                  95      


Pro Leu Tyr Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  290
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_1 from FIG. 11B

<400>  290
gguccucggg gcauguuccg                                                   20


<210>  291
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_2 from FIG. 11B

<400>  291
gggcauguuc cgaggggacc                                                   20


<210>  292
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_4 from FIG. 11B

<400>  292
uccucggggc auguuccgag                                                   20


<210>  293
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_5 from FIG. 11B

<400>  293
ggcauguucc gaggggaccu                                                   20


<210>  294
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_7 from FIG. 11B

<400>  294
agcauugcag guugguccuc                                                   20


<210>  295
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_8 from FIG. 11B

<400>  295
ccugggcgga cuggccagga                                                   20


<210>  296
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_9 from FIG. 11B

<400>  296
acuggggugc cuugaggauc                                                   20


<210>  297
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_10 from FIG. 11B

<400>  297
ccccagugcc cauccccucc                                                   20


<210>  298
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_11 from FIG. 11B

<400>  298
cuaagacccc ugguuuguuc                                                   20


<210>  299
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_12 from FIG. 11B

<400>  299
uguggauuuu ccgaugccuu                                                   20


<210>  300
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_13 from FIG. 11B

<400>  300
aggaccaacc ugcaaugcuc                                                   20


<210>  301
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_14 from FIG. 11B

<400>  301
cucagguugg gugcgucuga                                                   20


<210>  302
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_15

<400>  302
cccuccuggc caguccgccc                                                   20


<210>  303
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_16 from FIG. 11B

<400>  303
ggccaggagg ggaugggcac                                                   20


<210>  304
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_17

<400>  304
gagaugccug aacaaaccag                                                   20


<210>  305
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_18 from FIG. 11B

<400>  305
aggggucuua gugauggcug                                                   20


<210>  306
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_19 from FIG. 11B

<400>  306
augggcacug gggugccuug                                                   20


<210>  307
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human _1_gRNA_20 from FIG. 11B

<400>  307
uuccgaugcc uuuggaaaau                                                   20


<210>  308
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_1 from FIG. 12B

<400>  308
cugacgccgc aucggugauu                                                   20


<210>  309
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_2 from FIG. 12B

<400>  309
uuagacaagg gcgaugccag                                                   20


<210>  310
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_3 from FIG. 12B

<400>  310
cgugcgaccu cuccuucaaa                                                   20


<210>  311
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_4 from FIG. 12B

<400>  311
agcauaucuu cugcaccaag                                                   20


<210>  312
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_5 from FIG. 12B

<400>  312
auauuccacc cagguagugg                                                   20


<210>  313
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_6 from FIG. 12B

<400>  313
gugcgaccuc uccuucaaau                                                   20


<210>  314
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_7 from FIG. 12B

<400>  314
agguccccuu gcucuagaag                                                   20


<210>  315
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_8 from FIG. 12B

<400>  315
cucuagauaa cagucaucau                                                   20


<210>  316
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_9 from FIG. 12B

<400>  316
uugucuaagu cauugacugu                                                   20


<210>  317
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_10 from FIG. 12B

<400>  317
ccaaagcgau uuaugguaaa                                                   20


<210>  318
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_11 from FIG. 12B

<400>  318
ucuuuugagu gaccauuguc                                                   20


<210>  319
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_12 from FIG. 12B

<400>  319
ccauuuacca uaaaucgcuu                                                   20


<210>  320
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_13 from FIG. 12B

<400>  320
agggcgaugc caguggggcu                                                   20


<210>  321
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_14 from FIG. 12B

<400>  321
agcuaaagcc aucucauugc                                                   20


<210>  322
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_15 from FIG. 12B

<400>  322
ccacaaccuc ugaaugggga                                                   20


<210>  323
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_16 from FIG. 12B

<400>  323
uuaauugcuu gaugaagagc                                                   20


<210>  324
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_17 from FIG. 12B

<400>  324
uagacaaggg cgaugccagu                                                   20


<210>  325
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_18 from FIG. 12B

<400>  325
aagcugaccu agacuaaaca                                                   20


<210>  326
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_19 from FIG. 12B

<400>  326
gcaggaaccc ggcaaugaga                                                   20


<210>  327
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Human_2_gRNA_20 from FIG. 12B

<400>  327
ucuguuccga aucaccgaug                                                   20


<210>  328
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_1 from FIG. 13B

<400>  328
caacuacccu uuugagaccg                                                   20


<210>  329
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_3 from FIG. 13B

<400>  329
uauacaguau ccgaugcaua                                                   20


<210>  330
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_4 from FIG. 13B

<400>  330
caucuagccu cggucucaaa                                                   20


<210>  331
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_5 from FIG. 13B

<400>  331
cacucuuugu cccuaugcau                                                   20


<210>  332
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_6 from FIG. 13B

<400>  332
aucuagccuc ggucucaaaa                                                   20


<210>  333
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_7 from FIG. 13B

<400>  333
aaguuuuaaa caaucuagug                                                   20


<210>  334
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_8 from FIG. 13B

<400>  334
aagaugcuaa aacaauccua                                                   20


<210>  335
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_9 from FIG. 13B

<400>  335
ugcuaaaaca auccuauggc                                                   20


<210>  336
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_10 from FIG. 13B

<400>  336
aagucccuau cccaucaucc                                                   20


<210>  337
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_11 from FIG. 13B

<400>  337
gggagaaagg caucuagccu                                                   20


<210>  338
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_12 from FIG. 13B

<400>  338
ugagcauugc agacuaaucu                                                   20


<210>  339
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_13 from FIG. 13B

<400>  339
uuaguugugg aauauacuuc                                                   20


<210>  340
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_14 from FIG. 13B

<400>  340
ugguggaguc ccuggaugau                                                   20


<210>  341
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_15 from FIG. 13B

<400>  341
guggagauaa ucuguccuaa                                                   20


<210>  342
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_16 from FIG. 13B

<400>  342
agucccuauc ccaucaucca                                                   20


<210>  343
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_17 from FIG. 13B

<400>  343
aucuuggaua uuugucccug                                                   20


<210>  344
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_18 from FIG. 13B

<400>  344
gggauaguug gggcuguagu                                                   20


<210>  345
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_19 from FIG. 13B

<400>  345
cagguaagaa uggccucucc                                                   20


<210>  346
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Mouse_1_gRNA_20 from FIG. 13B

<400>  346
ucucucagcc ggcucccuca                                                   20


<210>  347
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__1 from FIG. 14B

<400>  347
ccgaaaccag gcaccgcaaa                                                   20


<210>  348
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__2 from FIG. 14B

<400>  348
caccgcaaau gguaagccag                                                   20


<210>  349
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__3 from FIG. 14B

<400>  349
ggcuuaccau uugcggugcc                                                   20


<210>  350
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__4 from FIG. 14B

<400>  350
ugcggugccu gguuucggag                                                   20


<210>  351
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__5 from FIG. 14B

<400>  351
cagcuaugcu acgcuguguu                                                   20


<210>  352
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__6 from FIG. 14B

<400>  352
aaggacagug cuuagauccg                                                   20


<210>  353
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__7 from FIG. 14B

<400>  353
ucagucaguc agugacguga                                                   20


<210>  354
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__8 from FIG. 14B

<400>  354
caugcugguu ggugguugag                                                   20


<210>  355
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__9 from FIG. 14B

<400>  355
ucuuuugagu accguugucu                                                   20


<210>  356
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__10 from FIG. 14B

<400>  356
uggcccauuc aacaauaagc                                                   20


<210>  357
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__11 from FIG. 14B

<400>  357
cugggccgcu aagcuaaacu                                                   20


<210>  358
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__12 from FIG. 14B

<400>  358
gccagccuag uuuagcuuag                                                   20


<210>  359
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__13 from FIG. 14B

<400>  359
ugaaguagac uguaaugaac                                                   20


<210>  360
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__14 from FIG. 14B

<400>  360
gaccugggaa uguaugguug                                                   20


<210>  361
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__15 from FIG. 14B

<400>  361
gguauggaua cgcagaagga                                                   20


<210>  362
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__16 from FIG. 14B

<400>  362
guugagagcc cuaguaagcg                                                   20


<210>  363
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__17 from FIG. 14B

<400>  363
gccgcuaagc uaaacuaggc                                                   20


<210>  364
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__18 from FIG. 14B

<400>  364
ucagcuaugc uacgcugugu                                                   20


<210>  365
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__19 from FIG. 14B

<400>  365
uuuuagagcc ucgcuuacua                                                   20


<210>  366
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MOUSE_2_gRNA__20 from FIG. 14B

<400>  366
cucuaugauu auugguuaac                                                   20


