                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Nowak, Radoslaw
       Fischer, Eric
       Gray, Nathanael S.
       Zhang, Tinghu
       He, Zhixiang
 
<120>  Heterobifunctional Compounds with Improved Specificity

<130>  52095-562001WO

<140>  PCT/US18/56680
<141>  2018-10-19

<150>  US 62/575,156
<151>  2017-10-20

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  1

Trp Lys His Gln Phe Ala Trp Pro Phe Arg Gln Pro Val Asp Ala Val 
1               5                   10                  15      


Lys Leu Gly Leu Pro Asp Tyr His Lys Ile Ile Lys Gln Pro Met Asp 
            20                  25                  30          


Met Gly Thr Ile Lys Arg Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala 
        35                  40                  45              


Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile 
    50                  55                  60                  


Tyr Asn Lys Pro Thr Asp Asp Ile Val 
65                  70              


<210>  2
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  2

Trp Lys His Ser Phe Ser Trp Pro Phe Gln Arg Pro Val Asp Ala Val 
1               5                   10                  15      


Lys Leu Gln Leu Pro Asp Tyr Tyr Thr Ile Ile Lys Asn Pro Met Asp 
            20                  25                  30          


Leu Asn Thr Ile Lys Lys Arg Leu Glu Asn Lys Tyr Tyr Ala Lys Ala 
        35                  40                  45              


Ser Glu Cys Ile Glu Asp Phe Asn Thr Met Phe Ser Asn Cys Tyr Leu 
    50                  55                  60                  


Tyr Asn Lys Pro Gly Asp Asp Ile Val 
65                  70              


<210>  3
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  3

Trp Lys His Gln Phe Ala Trp Pro Phe Tyr Gln Pro Val Asp Ala Ile 
1               5                   10                  15      


Lys Leu Asn Leu Pro Asp Tyr His Lys Ile Ile Lys Asn Pro Met Asp 
            20                  25                  30          


Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Ser Ala 
        35                  40                  45              


Ser Glu Cys Met Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile 
    50                  55                  60                  


Tyr Asn Lys Pro Thr Asp Asp Ile Val 
65                  70              


<210>  4
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  4

Trp Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala Val 
1               5                   10                  15      


Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp 
            20                  25                  30          


Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala 
        35                  40                  45              


Gln Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile 
    50                  55                  60                  


Tyr Asn Lys Pro Gly Asp Asp Ile Val 
65                  70              


<210>  5
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  5

Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser 
1               5                   10                  15      


Ala Leu Gly Leu His Asp Tyr His Asp Ile Ile Lys His Pro Met Asp 
            20                  25                  30          


Leu Ser Thr Val Lys Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala 
        35                  40                  45              


Gln Glu Phe Ala Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys 
    50                  55                  60                  


Tyr Asn Pro Pro Asp His Asp Val Val 
65                  70              


<210>  6
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  6

Lys His Phe Ser Tyr Ala Trp Pro Phe Tyr Asn Pro Val Asp Val Asn 
1               5                   10                  15      


Ala Leu Gly Leu His Asn Tyr Tyr Asp Val Val Lys Asn Pro Met Asp 
            20                  25                  30          


Leu Gly Thr Ile Lys Glu Lys Met Asp Asn Gln Glu Tyr Lys Asp Ala 
        35                  40                  45              


Tyr Lys Phe Ala Ala Asp Val Arg Leu Met Phe Met Asn Cys Tyr Lys 
    50                  55                  60                  


Tyr Asn Pro Pro Asp His Glu Val Val 
65                  70              


<210>  7
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  7

Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Glu 
1               5                   10                  15      


Ala Leu Glu Leu His Asp Tyr His Asp Ile Ile Lys His Pro Met Asp 
            20                  25                  30          


Leu Ser Thr Val Lys Arg Lys Met Asp Gly Arg Glu Tyr Pro Asp Ala 
        35                  40                  45              


Gln Gly Phe Ala Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys 
    50                  55                  60                  


Tyr Asn Pro Pro Asp His Glu Val Val 
65                  70              


<210>  8
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BET bromodomain paralog

<400>  8

Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu 
1               5                   10                  15      


Ala Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp 
            20                  25                  30          


Met Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala 
        35                  40                  45              


Gln Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys 
    50                  55                  60                  


Tyr Asn Pro Pro Asp His Glu Val Val 
65                  70              


<210>  9
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  9

Trp Lys His Gln Phe Ala Trp Pro Phe Gln Gln Pro Val Asp Ala Val 
1               5                   10                  15      


Lys Leu Asn Leu Pro Asp Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp 
            20                  25                  30          


Met Gly Thr Ile Lys Lys Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala 
        35                  40                  45              


Gln Glu Cys Ile Gln Asp Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile 
    50                  55                  60                  


Tyr Asn Lys Pro Gly Asp Asp Ile Val 
65                  70              


<210>  10
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys His Ala Ala Tyr Ala Trp Pro Phe Tyr Lys Pro Val Asp Val Glu 
1               5                   10                  15      


Ala Leu Gly Leu His Asp Tyr Cys Asp Ile Ile Lys His Pro Met Asp 
            20                  25                  30          


Met Ser Thr Ile Lys Ser Lys Leu Glu Ala Arg Glu Tyr Arg Asp Ala 
        35                  40                  45              


Gln Glu Phe Gly Ala Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys 
    50                  55                  60                  


Tyr Asn Pro Pro Asp His Glu Val Val
65                  70