                         SEQUENCE LISTING

<110>  Whitehead Institute for Biomedical Research
 
<120>  METHODS OF IDENTIFYING MODULATORS OF SAMTOR-GATOR1 INTERACTION 
       AND USE OF SAME TO MODULATE mTORC1

<130>  WIBR-164-WO1

<140>  PCT/US2018/056547
<141>  2018-10-18

<150>  US 62/574,623
<151>  2017-10-19

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  F-dsGFP primer

<400>  1
gaattaatac gactcactat agggagaagc tgaccctgaa gttcatctg                   49


<210>  2
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  R-dsGFP primer

<400>  2
gaattaatac gactcactat agggagatat agacgttgtg gctgttgtag tt               52


<210>  3
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  F-dsdSamtor primer

<400>  3
gaattaatac gactcactat agggagatgg aatcctacag agccgaggg                   49


<210>  4
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  R-dsdSamtor primer

<400>  4
gaattaatac gactcactat agggagacgt acccgtagca gtccaatcct g                51


<210>  5
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  F-dsdSesn primer

<400>  5
gaattaatac gactcactat agggagagac tacgactatg gcgaagtgaa                  50


<210>  6
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  R-dsdSesn primer

<400>  6
gaattaatac gactcactat agggagatca agtcatatag cgcattatct cg               52


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  F-alpha-tubulin primer

<400>  7
caaccagatg gtcaagtgcg                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  R-alpha-tubulin primer

<400>  8
acgtccttgg gcacaacatc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  F-dSamtor primer

<400>  9
gaccaacgat gggaaggtgg                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  R-dSamtor primer

<400>  10
gctctgtagg attccaggag t                                                 21


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  F-dSesn primer

<400>  11
tccgctgcct aacgattaca g                                                 21


<210>  12
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  R-dSesn primer

<400>  12
ttcaccagat acggacactg a                                                 21


<210>  13
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgSAMTOR_guide1_S

<400>  13
caccggaaat actgctcgtg cgcag                                             25


<210>  14
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgSAMTOR_guide1_AS

<400>  14
aaacctgcgc acgagcagta tttcc                                             25


<210>  15
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgSAMTOR_1 (S)

<400>  15
caccggaaat actgctcgtg cgcag                                             25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgSAMTOR_1 (AS)

<400>  16
aaacctgcgc acgagcagta tttcc                                             25


<210>  17
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgSAMTOR_2 (S)

<400>  17
caccggatat ggagccaggg gccgg                                             25


<210>  18
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgSAMTOR_2 (AS)

<400>  18
aaacccggcc cctggctcca tatcc                                             25


<210>  19
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMmSamtor_1 (S)

<400>  19
caccggcagg agaagctgtc cgggg                                             25


<210>  20
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMmSamtor_1 (AS)

<400>  20
aaaccgccac taagaccact ccagc                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMmSamtor_2 (S)

<400>  21
caccgctccg caagaagtac cgcga                                             25


<210>  22
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMmSamtor_2 (AS)

<400>  22
aaactcgcgg tacttcttgc ggagc                                             25


<210>  23
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMmSamtor_3 (S)

<400>  23
caccgatgaa cgctcttcac caccc                                             25


<210>  24
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMmSamtor_3 (AS)

<400>  24
aaacgggtgg tgaagagcgt tcatc                                             25


<210>  25
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMAT2A_1 (S)

<400>  25
caccgttaaa ggaggtctgt gccgg                                             25


<210>  26
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  sgMAT2A_1 (AS)

<400>  26
aaacccggca cagacctcct ttaac                                             25


<210>  27
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  28
<211>  29
<212>  PRT
<213>  Pan troglodytes

<400>  28

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  29
<211>  29
<212>  PRT
<213>  Macaca mulatta

<400>  29

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  30
<211>  29
<212>  PRT
<213>  Callithrix jacchus

<400>  30

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  31
<211>  29
<212>  PRT
<213>  Mus musculus

<400>  31

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  32
<211>  29
<212>  PRT
<213>  Gallus gallus

<400>  32

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  33
<211>  29
<212>  PRT
<213>  Xenopus tropicalis

<400>  33

Ile Arg Leu Leu Asp Val Gly Ser Cys Tyr Asn Pro Phe Leu Lys Tyr 
1               5                   10                  15      


Glu Asp Phe Leu Ala Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Danio rerio

<400>  34

Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Leu Lys Phe 
1               5                   10                  15      


Asp Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Drosophila melanogaster

<400>  35

Leu His Val Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Ser Ser Ala 
1               5                   10                  15      


Pro His Leu Glu Val Thr Ala Leu Asp Leu Cys Pro Ala 
            20                  25                  


<210>  36
<211>  29
<212>  PRT
<213>  Hydra vulgaris

<400>  36

Ile Val Leu Leu Asp Val Gly Ser Cys Phe Asn Gly Phe Lys Glu Phe 
1               5                   10                  15      


Asn Glu Phe Leu Val Phe Pro Ile Asp Ile Ala Pro Ala 
            20                  25                  


<210>  37
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Ala Gln Arg Ala 
1               5                   10                  15      


Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu 
            20                  25                  30          


Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg 
        35                  40                  45              


Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His 
    50                  55                  60                  


Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn 
65                  70                  75                  80  


Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile 
                85                  90                  95      


Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys 
            100                 105                 110         


Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys 
        115                 120                 125             


Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly His 
    130                 135                 140                 


Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn 
                165                 170                 175     


Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val 
            180                 185                 190         


Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu 
        195                 200                 205             


Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys 
    210                 215                 220                 


Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val 
225                 230                 235                 240 


Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg 
                245                 250                 255     


Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu 
            260                 265                 270         


Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met 
        275                 280                 285             


Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg 
    290                 295                 300                 


Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys 
305                 310                 315                 320 


Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly 
                325                 330                 335     


Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr 
            340                 345                 350         


Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu 
        355                 360                 365             


Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser 
    370                 375                 380                 


Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro 
385                 390                 395                 400 


Ile Leu Leu Leu Ser 
                405 


<210>  38
<211>  405
<212>  PRT
<213>  Pan troglodytes

<400>  38

Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Gly Gln Arg Ala 
1               5                   10                  15      


Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu 
            20                  25                  30          


Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg 
        35                  40                  45              


Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His 
    50                  55                  60                  


Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn 
65                  70                  75                  80  


Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile 
                85                  90                  95      


Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys 
            100                 105                 110         


Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys 
        115                 120                 125             


Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly His 
    130                 135                 140                 


Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn 
                165                 170                 175     


Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val 
            180                 185                 190         


Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu 
        195                 200                 205             


Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys 
    210                 215                 220                 


Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val 
225                 230                 235                 240 


Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg 
                245                 250                 255     


Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu 
            260                 265                 270         


Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met 
        275                 280                 285             


Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg 
    290                 295                 300                 


Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys 
305                 310                 315                 320 


Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly 
                325                 330                 335     


Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr 
            340                 345                 350         


Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu 
        355                 360                 365             


Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser 
    370                 375                 380                 


Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro 
385                 390                 395                 400 


Ile Leu Leu Leu Ser 
                405 


<210>  39
<211>  405
<212>  PRT
<213>  Macaca mulatta

<400>  39

Met Glu Pro Gly Ala Gly Gly Arg Ser Thr Ala Arg Gly Gln Arg Ala 
1               5                   10                  15      


Gly Pro Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu 
            20                  25                  30          


Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg 
        35                  40                  45              


Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His 
    50                  55                  60                  


Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn 
65                  70                  75                  80  


Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile 
                85                  90                  95      


Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys 
            100                 105                 110         


Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys 
        115                 120                 125             


Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Lys Leu Glu Gly His 
    130                 135                 140                 


Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn 
                165                 170                 175     


Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val 
            180                 185                 190         


Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu 
        195                 200                 205             


Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys 
    210                 215                 220                 


Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val 
225                 230                 235                 240 


Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg 
                245                 250                 255     


Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu 
            260                 265                 270         


Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met 
        275                 280                 285             


Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg 
    290                 295                 300                 


Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys 
305                 310                 315                 320 


Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly 
                325                 330                 335     


Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr 
            340                 345                 350         


Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu 
        355                 360                 365             


Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser 
    370                 375                 380                 


Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro 
385                 390                 395                 400 


Ile Leu Leu Leu Ser 
                405 


<210>  40
<211>  405
<212>  PRT
<213>  Callithrix jacchus

<400>  40

Met Glu Pro Gly Ala Gly Gly Arg Ser Thr Ala Arg Gly Gln Lys Ala 
1               5                   10                  15      


Gly His Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu 
            20                  25                  30          


Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg 
        35                  40                  45              


Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His 
    50                  55                  60                  


Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn 
65                  70                  75                  80  


Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile 
                85                  90                  95      


Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys 
            100                 105                 110         


Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys 
        115                 120                 125             


Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Lys Leu Glu Gly His 
    130                 135                 140                 


Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn 
                165                 170                 175     


Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val 
            180                 185                 190         


Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu 
        195                 200                 205             


Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys 
    210                 215                 220                 


Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val 
225                 230                 235                 240 


Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg 
                245                 250                 255     


Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu 
            260                 265                 270         


Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met 
        275                 280                 285             


Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg 
    290                 295                 300                 


Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys 
305                 310                 315                 320 


Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly 
                325                 330                 335     


Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr 
            340                 345                 350         


Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu 
        355                 360                 365             


Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser 
    370                 375                 380                 


Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro 
385                 390                 395                 400 


Ile Leu Leu Leu Ser 
                405 


<210>  41
<211>  403
<212>  PRT
<213>  Mus musculus

<400>  41

Met Glu Pro Gly Pro Gly Gly Arg Gly Ala Ala Arg Gly Gln Arg Pro 
1               5                   10                  15      


Pro Asn Ala Ala Gln Pro Arg Glu Gln Glu Arg Lys Leu Glu Gln Glu 
            20                  25                  30          


Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg Lys Lys 
        35                  40                  45              


Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His Cys Glu 
    50                  55                  60                  


Asp Ala Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn Leu Ala 
65                  70                  75                  80  


Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile Glu Trp 
                85                  90                  95      


Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys Arg Lys 
            100                 105                 110         


Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys Thr Thr 
        115                 120                 125             


Pro Ala Leu Asn Val His Glu Ser Ser Lys Leu Glu Gly Pro Leu Thr 
    130                 135                 140                 


Asn Leu Ser Phe Thr Ser Pro Asp Phe Ile Thr Glu Leu Leu Gln Ala 
145                 150                 155                 160 


Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn Pro Phe 
                165                 170                 175     


Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val Pro Ala 
            180                 185                 190         


Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu Gln Gln 
        195                 200                 205             


Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys Gln Leu 
    210                 215                 220                 


Arg Asn Pro Ile Asp Ala Leu Pro Gly Glu Leu Phe His Val Val Val 
225                 230                 235                 240 


Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg Trp Ile 
                245                 250                 255     


Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu Leu Leu 
            260                 265                 270         


Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met Met Met 
        275                 280                 285             


Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg Phe Lys 
    290                 295                 300                 


Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys Thr Ser 
305                 310                 315                 320 


Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly Met Leu 
                325                 330                 335     


Tyr Ile Pro Gln Asp Phe Asn Ser Val Glu Glu Glu Glu Tyr Ser Asn 
            340                 345                 350         


Thr Ser Cys Tyr Val Arg Ser Asp Leu Glu Asp Glu Gln Leu Ala Tyr 
        355                 360                 365             


Gly Phe Thr Glu Leu Pro Glu Ala Pro Tyr Asp Ser Asp Ser Gly Glu 
    370                 375                 380                 


Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro Ile Leu 
385                 390                 395                 400 


Leu Leu Ser 
            


<210>  42
<211>  408
<212>  PRT
<213>  Gallus gallus

<400>  42

Met Glu Ala Ala Pro Arg Ser Arg Pro Arg Pro Gly Gly Ala Ala Ala 
1               5                   10                  15      


Ser Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Glu Gln Glu Arg Lys 
            20                  25                  30          


Leu Glu Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg 
        35                  40                  45              


Leu Arg Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg 
    50                  55                  60                  


Glu His Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met 
65                  70                  75                  80  


Lys Asn Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly 
                85                  90                  95      


Arg Ile Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly 
            100                 105                 110         


Gly Lys Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Leu Leu Ala 
        115                 120                 125             


Ser Lys Ser Thr Pro Ala Leu Asn Ala Ser Gln Pro Pro Lys Ile Glu 
    130                 135                 140                 


Asp Pro Leu Pro Asn Phe Gly Leu Thr Asn His Glu Ala Ile Thr Glu 
145                 150                 155                 160 


Glu Leu Leu His Ser Leu Gly Lys Ile Arg Leu Leu Asp Val Gly Ser 
                165                 170                 175     


Cys Phe Asn Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile 
            180                 185                 190         


Asp Ile Val Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn 
        195                 200                 205             


Leu Gln Ile Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala 
    210                 215                 220                 


Phe Leu Lys Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu 
225                 230                 235                 240 


Phe His Val Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro 
                245                 250                 255     


Tyr Gln Arg Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu 
            260                 265                 270         


Asn Gly Leu Leu Leu Val Ile Thr Pro Asp Ser Ser His Gln Asn Arg 
        275                 280                 285             


Arg Ala Met Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly 
    290                 295                 300                 


Phe Lys Arg Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala 
305                 310                 315                 320 


Phe Arg Lys Thr Ser Leu Gln Thr Thr Ser Asp Leu Val Ser Arg Asn 
                325                 330                 335     


Tyr Pro Gly Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp 
            340                 345                 350         


Glu Glu Tyr Ser Asn Thr Ser Cys Tyr Ile Arg Ser Asp Met Glu Asp 
        355                 360                 365             


Glu Gln Leu Ala Tyr Gly Phe Met Glu Leu Pro Asp Ala Pro Tyr Asp 
    370                 375                 380                 


Ser Asp Ser Gly Glu Ser Gln Ser Ser Ser Ile Pro Phe Tyr Glu Leu 
385                 390                 395                 400 


Glu Asp Pro Val Leu Leu Leu Ser 
                405             


<210>  43
<211>  410
<212>  PRT
<213>  Xenopus tropicalis

<400>  43

Met Glu Pro Val Leu Gln Ala Arg Gly Lys Arg Glu Asn Val Leu Gly 
1               5                   10                  15      


Asn Ala Arg Glu Glu Arg Cys Val Pro Gly Phe Pro Ser Ala Cys Glu 
            20                  25                  30          


Gln Lys Leu Glu Gln Glu Lys Leu Ser Gly Val Val Lys Arg Val His 
        35                  40                  45              


Arg Asp Leu Arg Lys Lys Tyr Arg Glu Ala Gly Asp Phe Glu Lys Ile 
    50                  55                  60                  


Trp Leu Glu His Cys Lys Asp Lys Gly Arg Leu Cys Glu Tyr Ala Val 
65                  70                  75                  80  


Ala Met Lys Ala Leu Ala Asp Asn His Trp Ala Lys Lys Cys Glu Gly 
                85                  90                  95      


Glu Gly Arg Ile Glu Trp Cys Leu Gly Val Cys Gln Glu Tyr Phe Phe 
            100                 105                 110         


Asn Gly Gly Lys Lys Lys Ala Ile Glu Lys Asp Ala Arg Arg Ala Thr 
        115                 120                 125             


Leu Ile Cys Lys Arg Tyr Val Thr Ser Pro Ile Asn Asn Thr Glu Gln 
    130                 135                 140                 


Thr Asn His Glu Gly Phe Pro Thr Leu Glu Asn Ser Lys Gln Asn Asp 
145                 150                 155                 160 


Phe Val Leu Lys Leu Lys Tyr Met Thr Gly Lys Ile Arg Leu Leu Asp 
                165                 170                 175     


Val Gly Ser Cys Tyr Asn Pro Phe Leu Lys Tyr Glu Asp Phe Leu Ala 
            180                 185                 190         


Val Gly Ile Asp Ile Val Pro Ala Val Glu Thr Val Cys Lys Cys Asp 
        195                 200                 205             


Phe Leu Asn Leu Gln Ile Gln Arg Pro Leu Gln Phe Ala Pro Asp Ala 
    210                 215                 220                 


Ile Asp Ala Phe Leu Lys Gln Leu Glu Ser Pro Ile Asp Tyr Leu Pro 
225                 230                 235                 240 


Ala Glu Leu Phe His Val Val Val Phe Ser Leu Leu Leu Ser Tyr Phe 
                245                 250                 255     


Pro Ser Pro Tyr Gln Arg Trp Ile Cys Cys Lys Lys Ala His Glu Leu 
            260                 265                 270         


Leu Thr Leu Asn Gly Leu Leu Leu Ile Ile Thr Pro Asp Ser Ser His 
        275                 280                 285             


Gln Asn Arg His Ala Val Met Met Lys Ser Trp Lys Ile Ala Ile Glu 
    290                 295                 300                 


Ser Leu Gly Phe Arg Arg Met Thr Tyr Ser Lys Phe Ser His Met His 
305                 310                 315                 320 


Leu Met Ala Phe Arg Lys Thr Ser Leu Lys Thr Thr Ser Asp Leu Ile 
                325                 330                 335     


Thr Met Asn Tyr Pro Asp Met Leu Tyr Ile Pro Gln Asp Phe Asn Tyr 
            340                 345                 350         


Asp Gly Glu Glu Asp Tyr Phe Ser Pro Cys Cys Ala Arg Ser Glu Leu 
        355                 360                 365             


Glu Asp Glu Gln Leu Ala Cys Gly Phe Thr Glu Leu Pro Asp Thr Pro 
    370                 375                 380                 


Tyr Asp Ser Asp Ser Gly Glu Ser Gln Asn Ser Thr Met Pro Phe Tyr 
385                 390                 395                 400 


Glu Phe Glu Asp Pro Ile Leu Leu Leu Thr 
                405                 410 


<210>  44
<211>  393
<212>  PRT
<213>  Danio rerio

<400>  44

Met Asp Leu Arg Ser Ser Ala Glu Thr Asp Pro Asp Leu Ser Glu Asn 
1               5                   10                  15      


His Pro Gly Ser Val Pro Ala Glu Leu Gln Ser Arg Lys Gln Glu Gln 
            20                  25                  30          


Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Lys Leu Arg Arg 
        35                  40                  45              


Lys Tyr Ile Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His Cys 
    50                  55                  60                  


Glu Asp Glu Gln Thr Leu Ser Glu Tyr Ala Met Ala Met Lys Asn Leu 
65                  70                  75                  80  


Ala Asp Asn His Trp Ala Asn Lys Cys Glu Gly Glu Gly Arg Ile Glu 
                85                  90                  95      


Trp Cys Arg Ser Val Cys Gln Glu Tyr Phe Gln Asp Gly Gly Met Arg 
            100                 105                 110         


Arg Val Leu Glu Lys Asp Glu Lys Ser Ala Arg His Ala Thr Ala Gly 
        115                 120                 125             


Asn Ala Asn Thr Asp Thr Asn Ala Pro Pro Gln Leu Ser Ser Ile Ser 
    130                 135                 140                 


Thr Ser Ser Thr Phe Gln Leu Gly Arg Ile Arg Leu Leu Asp Val Gly 
145                 150                 155                 160 


Ser Cys Phe Asn Pro Phe Leu Lys Phe Asp Glu Phe Leu Thr Val Gly 
                165                 170                 175     


Ile Asp Ile Val Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu 
            180                 185                 190         


Asn Leu Gln Leu Gln Gln Pro Leu Gln Leu Ala Ser Asp Ala Leu Asp 
        195                 200                 205             


Ala Phe Leu Arg Gln Leu Arg Gly Pro Ile Asp Ala Leu Pro Ala Glu 
    210                 215                 220                 


Leu Phe His Val Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser 
225                 230                 235                 240 


Pro Tyr Gln Arg Trp Leu Cys Cys Lys Lys Ala His Glu Leu Leu Thr 
                245                 250                 255     


Leu Asn Gly Leu Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Gly 
            260                 265                 270         


Arg His Ala Leu Met Met Arg Ser Trp Arg Val Ala Val Glu Ser Leu 
        275                 280                 285             


Gly Phe Lys Arg Tyr Lys Tyr Val Lys Phe Ser His Met His Leu Ile 
    290                 295                 300                 


Ala Phe Arg Lys Val Ser Pro Thr Thr Ser Ser Asp Leu Val Ser Arg 
305                 310                 315                 320 


Asn Tyr Pro Glu Met Leu Tyr Ile Pro Gln Asp Phe Asn Thr Phe Asp 
                325                 330                 335     


Glu Asp Gly Phe Ala Asp Cys Tyr Glu Pro Pro Arg Ser Asp Phe Glu 
            340                 345                 350         


Asp Asp Gln Met Ala Cys Ser Phe Ala Glu Leu Pro Glu Thr Pro Tyr 
        355                 360                 365             


Asp Ser Asp Ser Ser Glu Ser Gln Ser Ser Ser Ala Pro Phe Tyr Glu 
    370                 375                 380                 


Leu Glu Asp Pro Ile Leu Leu Gln Ser 
385                 390             


<210>  45
<211>  302
<212>  PRT
<213>  Drosophila melanogaster

<400>  45

Met Ala Thr Glu Glu His Gln Arg Leu Ala Ser Ile Val Lys Ser Cys 
1               5                   10                  15      


His Glu Ser Leu Arg Gln Leu Thr Lys Glu Tyr Gly Ala Thr Ala Ala 
            20                  25                  30          


Trp Gln Glu His Thr Ser Pro Arg Asn Ala Lys Gln Leu Ala Glu Tyr 
        35                  40                  45              


Ala Lys Ala Met Lys Gln Leu Ala Ala Ile Trp Glu Thr Asn Asp Gly 
    50                  55                  60                  


Lys Val Glu Leu Gln Ala Arg Ser Arg Ile Lys Trp Ala Ile Asp Tyr 
65                  70                  75                  80  


Ile Thr Lys Tyr Phe Phe Thr Glu Gly Ile Tyr Leu Gln Lys Arg Gln 
                85                  90                  95      


Arg Glu Gln Arg Leu Leu Glu Ser Tyr Arg Ala Glu Gly Lys Leu Gly 
            100                 105                 110         


Glu Val Gln Cys Arg Leu Met Glu Glu Pro Pro Asp Arg Leu His Val 
        115                 120                 125             


Leu Asp Val Gly Ser Cys Phe Asn Pro Phe Ser Ser Ala Pro His Leu 
    130                 135                 140                 


Glu Val Thr Ala Leu Asp Leu Cys Pro Ala Thr Glu Asp Val Leu Gln 
145                 150                 155                 160 


Ala Asp Phe Leu Lys Val Glu Val Val Pro Gly Ile Arg Glu Pro Glu 
                165                 170                 175     


Leu Glu Glu Gly Ser Val Arg Arg Leu Pro Ala Ser His Tyr Glu Cys 
            180                 185                 190         


Val Ile Phe Ser Leu Leu Leu Glu Tyr Met Pro Ser Ala Glu Gln Arg 
        195                 200                 205             


Leu Gln Cys Cys Leu Gln Ala Tyr Asp Leu Leu Leu Pro Glu Gly Ile 
    210                 215                 220                 


Leu Val Leu Ile Thr Pro Asp Ser Gln His Val Gly Lys Asn Ala His 
225                 230                 235                 240 


Leu Met Lys Asn Trp Arg Tyr Ser Leu Ala Arg Ile Gly Leu Leu Arg 
                245                 250                 255     


Val Arg Phe Glu Lys Leu Pro His Ile Ser Cys Met Val Phe Arg Lys 
            260                 265                 270         


Ala Ile Ser Arg Glu Leu Ser Gln His Trp Ala Ser Ile His Arg Glu 
        275                 280                 285             


Glu Gly Met Cys Glu Glu Ile Arg Ile Pro Gln Asp Asp Ser 
    290                 295                 300         


<210>  46
<211>  350
<212>  PRT
<213>  Hydra vulgaris

<400>  46

Lys Lys Phe Phe Met Phe Thr Met Asp Glu Ala Thr Lys Asn Ala Glu 
1               5                   10                  15      


Val Val Lys Lys Leu His Lys Thr Leu Arg Ser Lys Val Lys Lys Gly 
            20                  25                  30          


Tyr Pro Pro Asp Glu Val Trp Ala Asn Leu Leu Lys Asp Ser Asp Val 
        35                  40                  45              


Leu Ser Glu Tyr Ser Lys Ala Met Ser Ile Leu Ala Leu Gln Tyr Trp 
    50                  55                  60                  


Pro Lys Asp Thr Ser Gln Ser Arg Ile Lys Trp Ala Tyr Asn Val Cys 
65                  70                  75                  80  


Leu Glu Tyr Phe Tyr Asn Gly Gly Ala Tyr Lys Ser Ala Gln Lys Tyr 
                85                  90                  95      


Phe Lys Gln Gln Met Tyr Ser Ser Leu Glu Lys Asn Ile Val Thr Glu 
            100                 105                 110         


Tyr Glu Lys Leu Thr Ile Glu Ser Glu Leu Arg Ile Phe Glu Arg Asp 
        115                 120                 125             


Trp Lys Ser Leu Ile Thr Glu Lys Ile Val Leu Leu Asp Val Gly Ser 
    130                 135                 140                 


Cys Phe Asn Gly Phe Lys Glu Phe Asn Glu Phe Leu Val Phe Pro Ile 
145                 150                 155                 160 


Asp Ile Ala Pro Ala Thr Gln Asp Val Tyr Lys Leu Asp Phe Leu Asn 
                165                 170                 175     


Val Ala Phe Lys Glu Val Ser Gln Ser Phe Thr Ser Asp Gln Phe Thr 
            180                 185                 190         


Leu Val Thr Tyr Ile Arg Asp Asn Leu Thr Asp Ser Leu Leu Leu Lys 
        195                 200                 205             


Ala Val Phe Asp Val Val Val Phe Ser Leu Leu Leu Cys Tyr Leu Pro 
    210                 215                 220                 


Cys Pro Glu Gln Arg Leu Lys Cys Cys Ile Asn Ala His Ile Ser Leu 
225                 230                 235                 240 


Arg Leu Tyr Gly Leu Leu Ile Ile Ile Thr Pro Asp Ser Ser His Gln 
                245                 250                 255     


Asn Arg Asn Ala Lys Met Met Ala Ser Trp Lys Asn Ala Leu Glu Gly 
            260                 265                 270         


Ile Gly Phe Val Arg Tyr Lys Tyr Thr Lys Leu Glu His Phe His Cys 
        275                 280                 285             


Met Ala Phe Phe Lys Ala Asn Glu Thr Asn Ile Leu Leu Trp Glu Lys 
    290                 295                 300                 


Tyr Ser Arg Phe Leu Phe Ile Pro Gln Asp Phe Gln Glu Ile Lys Glu 
305                 310                 315                 320 


Glu Lys Val Asp Ile Asn Cys Ser Glu Glu Lys Phe Ser Ser Asn Tyr 
                325                 330                 335     


Asn Ile Glu Glu Leu Ile Gln Val Cys Asn Leu Ser Glu Leu 
            340                 345                 350 


<210>  47
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Pro Gly Ala Gly Gly Arg Asn Thr Ala Arg Ala Gln Arg Ala 
1               5                   10                  15      


Gly Ser Pro Asn Thr Pro Pro Pro Arg Glu Gln Glu Arg Lys Leu Glu 
            20                  25                  30          


Gln Glu Lys Leu Ser Gly Val Val Lys Ser Val His Arg Arg Leu Arg 
        35                  40                  45              


Lys Lys Tyr Arg Glu Val Gly Asp Phe Asp Lys Ile Trp Arg Glu His 
    50                  55                  60                  


Cys Glu Asp Glu Glu Thr Leu Cys Glu Tyr Ala Val Ala Met Lys Asn 
65                  70                  75                  80  


Leu Ala Asp Asn His Trp Ala Lys Thr Cys Glu Gly Glu Gly Arg Ile 
                85                  90                  95      


Glu Trp Cys Cys Ser Val Cys Arg Glu Tyr Phe Gln Asn Gly Gly Lys 
            100                 105                 110         


Arg Lys Ala Leu Glu Lys Asp Glu Lys Arg Ala Val Leu Ala Thr Lys 
        115                 120                 125             


Thr Thr Pro Ala Leu Asn Met His Glu Ser Ser Gln Leu Glu Gly His 
    130                 135                 140                 


Leu Thr Asn Leu Ser Phe Thr Asn Pro Glu Phe Ile Thr Glu Leu Leu 
145                 150                 155                 160 


Gln Ala Ser Gly Lys Ile Arg Leu Leu Asp Val Gly Ser Cys Phe Asn 
                165                 170                 175     


Pro Phe Leu Lys Phe Glu Glu Phe Leu Thr Val Gly Ile Asp Ile Val 
            180                 185                 190         


Pro Ala Val Glu Ser Val Tyr Lys Cys Asp Phe Leu Asn Leu Gln Leu 
        195                 200                 205             


Gln Gln Pro Leu Gln Leu Ala Gln Asp Ala Ile Asp Ala Phe Leu Lys 
    210                 215                 220                 


Gln Leu Lys Asn Pro Ile Asp Ser Leu Pro Gly Glu Leu Phe His Val 
225                 230                 235                 240 


Val Val Phe Ser Leu Leu Leu Ser Tyr Phe Pro Ser Pro Tyr Gln Arg 
                245                 250                 255     


Trp Ile Cys Cys Lys Lys Ala His Glu Leu Leu Val Leu Asn Gly Leu 
            260                 265                 270         


Leu Leu Ile Ile Thr Pro Asp Ser Ser His Gln Asn Arg His Ala Met 
        275                 280                 285             


Met Met Lys Ser Trp Lys Ile Ala Ile Glu Ser Leu Gly Phe Lys Arg 
    290                 295                 300                 


Phe Lys Tyr Ser Lys Phe Ser His Met His Leu Met Ala Phe Arg Lys 
305                 310                 315                 320 


Ile Ser Leu Lys Thr Thr Ser Asp Leu Val Ser Arg Asn Tyr Pro Gly 
                325                 330                 335     


Met Leu Tyr Ile Pro Gln Asp Phe Asn Ser Ile Glu Asp Glu Glu Tyr 
            340                 345                 350         


Ser Asn Pro Ser Cys Tyr Val Arg Ser Asp Ile Glu Asp Glu Gln Leu 
        355                 360                 365             


Ala Tyr Gly Phe Thr Glu Leu Pro Asp Ala Pro Tyr Asp Ser Asp Ser 
    370                 375                 380                 


Gly Glu Ser Gln Ala Ser Ser Ile Pro Phe Tyr Glu Leu Glu Asp Pro 
385                 390                 395                 400 


Ile Leu Leu Leu Ser 
                405 


<210>  48
<211>  240
<212>  PRT
<213>  Escherichia coli

<400>  48

Met Asn Ala Glu Lys Ser Pro Val Asn His Asn Val Asp His Glu Glu 
1               5                   10                  15      


Ile Ala Lys Phe Glu Ala Val Ala Ser Arg Trp Trp Asp Leu Glu Gly 
            20                  25                  30          


Glu Phe Lys Pro Leu His Arg Ile Asn Pro Leu Arg Leu Gly Tyr Ile 
        35                  40                  45              


Ala Glu Arg Ala Gly Gly Leu Phe Gly Lys Lys Val Leu Asp Val Gly 
    50                  55                  60                  


Cys Gly Gly Gly Ile Leu Ala Glu Ser Met Ala Arg Glu Gly Ala Thr 
65                  70                  75                  80  


Val Thr Gly Leu Asp Met Gly Phe Glu Pro Leu Gln Val Ala Lys Leu 
                85                  90                  95      


His Ala Leu Glu Ser Gly Ile Gln Val Asp Tyr Val Gln Glu Thr Val 
            100                 105                 110         


Glu Glu His Ala Ala Lys His Ala Gly Gln Tyr Asp Val Val Thr Cys 
        115                 120                 125             


Met Glu Met Leu Glu His Val Pro Asp Pro Gln Ser Val Val Arg Ala 
    130                 135                 140                 


Cys Ala Gln Leu Val Lys Pro Gly Gly Asp Val Phe Phe Ser Thr Leu 
145                 150                 155                 160 


Asn Arg Asn Gly Lys Ser Trp Leu Met Ala Val Val Gly Ala Glu Tyr 
                165                 170                 175     


Ile Leu Arg Met Val Pro Lys Gly Thr His Asp Val Lys Lys Phe Ile 
            180                 185                 190         


Lys Pro Ala Glu Leu Leu Gly Trp Val Asp Gln Thr Ser Leu Lys Glu 
        195                 200                 205             


Arg His Ile Thr Gly Leu His Tyr Asn Pro Ile Thr Asn Thr Phe Lys 
    210                 215                 220                 


Leu Gly Pro Gly Val Asp Val Asn Tyr Met Leu His Thr Gln Asn Lys 
225                 230                 235                 240 


<210>  49
<211>  218
<212>  PRT
<213>  Methanococcus maripaludis

<400>  49

Met Ser Glu Asn Lys Lys Lys Phe Asp Lys Lys Gly Ala Lys Asn Met 
1               5                   10                  15      


Asp Glu Ile Ser Lys Thr Leu Phe Ala Pro Ile Tyr Pro Ile Ile Ala 
            20                  25                  30          


Glu Asn Ile Ile Asn Arg Phe Gly Ile Thr Ala Gly Asn Cys Ile Asp 
        35                  40                  45              


Ile Gly Ser Gly Pro Gly Ala Leu Ser Ile Ala Leu Ala Lys Gln Ser 
    50                  55                  60                  


Asp Phe Ser Ile Arg Ala Leu Asp Phe Ser Lys His Met Asn Glu Ile 
65                  70                  75                  80  


Ala Leu Lys Asn Ile Ala Asp Ala Asp Leu Asn Asp Arg Ile Gln Ile 
                85                  90                  95      


Val Gln Gly Asp Val His Asn Ile Pro Ile Glu Asp Asn Tyr Ala Asp 
            100                 105                 110         


Leu Ile Val Ser Arg Gly Ser Val Phe Phe Trp Glu Asp Val Thr Thr 
        115                 120                 125             


Ala Phe Arg Glu Ile Tyr Arg Ile Leu Lys Ser Gly Gly Lys Thr Tyr 
    130                 135                 140                 


Ile Gly Gly Gly Phe Gly Asn Lys Glu Leu Arg Asp Ser Ile Ser Ala 
145                 150                 155                 160 


Glu Met Ile Arg Lys Asn Pro Asp Trp Lys Glu Phe Asn Arg Lys Asn 
                165                 170                 175     


Ile Ser Gln Glu Asn Val Glu Arg Phe Gln Asn Val Leu Asp Glu Ile 
            180                 185                 190         


Gly Val Ser Ser Tyr Glu Ile Ile Leu Glu Asp Glu Gly Phe Trp Ile 
        195                 200                 205             


Ile Ile Ser Lys Thr Asp Gln Glu Val Ile 
    210                 215             


<210>  50
<211>  266
<212>  PRT
<213>  Plasmodium falciparum

<400>  50

Met Thr Leu Ile Glu Asn Leu Asn Ser Asp Lys Thr Phe Leu Glu Asn 
1               5                   10                  15      


Asn Gln Tyr Thr Asp Glu Gly Val Lys Val Tyr Glu Phe Ile Phe Gly 
            20                  25                  30          


Glu Asn Tyr Ile Ser Ser Gly Gly Leu Glu Ala Thr Lys Lys Ile Leu 
        35                  40                  45              


Ser Asp Ile Glu Leu Asn Glu Asn Ser Lys Val Leu Asp Ile Gly Ser 
    50                  55                  60                  


Gly Leu Gly Gly Gly Cys Met Tyr Ile Asn Glu Lys Tyr Gly Ala His 
65                  70                  75                  80  


Thr His Gly Ile Asp Ile Cys Ser Asn Ile Val Asn Met Ala Asn Glu 
                85                  90                  95      


Arg Val Ser Gly Asn Asn Lys Ile Ile Phe Glu Ala Asn Asp Ile Leu 
            100                 105                 110         


Thr Lys Glu Phe Pro Glu Asn Asn Phe Asp Leu Ile Tyr Ser Arg Asp 
        115                 120                 125             


Ala Ile Leu His Leu Ser Leu Glu Asn Lys Asn Lys Leu Phe Gln Lys 
    130                 135                 140                 


Cys Tyr Lys Trp Leu Lys Pro Thr Gly Thr Leu Leu Ile Thr Asp Tyr 
145                 150                 155                 160 


Cys Ala Thr Glu Lys Glu Asn Trp Asp Asp Glu Phe Lys Glu Tyr Val 
                165                 170                 175     


Lys Gln Arg Lys Tyr Thr Leu Ile Thr Val Glu Glu Tyr Ala Asp Ile 
            180                 185                 190         


Leu Thr Ala Cys Asn Phe Lys Asn Val Val Ser Lys Asp Leu Ser Asp 
        195                 200                 205             


Tyr Trp Asn Gln Leu Leu Glu Val Glu His Lys Tyr Leu His Glu Asn 
    210                 215                 220                 


Lys Glu Glu Phe Leu Lys Leu Phe Ser Glu Lys Lys Phe Ile Ser Leu 
225                 230                 235                 240 


Asp Asp Gly Trp Ser Arg Lys Ile Lys Asp Ser Lys Arg Lys Met Gln 
                245                 250                 255     


Arg Trp Gly Tyr Phe Lys Ala Thr Lys Asn 
            260                 265     


