                         SEQUENCE LISTING

<110>  Washington University
       DiAntonio, Aaron
       Milbrandt, Jeffrey
       Summers, Daniel
       Geisler, Stefanie
       Mao, Xianrong
 
<120>  DOMINANT NEGATIVE SARM1 MOLECULES AS A THERAPEUTIC STRATEGY FOR 
       NEURODEGENERATIVE DISEASES OR DISORDERS

<130>  047563-608551

<150>  62/573,967
<151>  2017-10-18

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  1

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Lys His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  2
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  2

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Tyr 
            180                 185                 190         


Lys His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  3
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  3

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Arg His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  4
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  4

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Ala His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  5
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  5

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Gln His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  6
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  6

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Glu His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  7
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  7

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Met His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  8
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  8

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Lys Ala Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  9
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  9

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Lys His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Ala Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  10
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  10

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Lys His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser Ala Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  11
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  11

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Arg His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Ala Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser His Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  12
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  12

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Lys His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Ala Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser Ala Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  13
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  13

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Arg His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Glu Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser Ala Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  14
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  14

Met Val Leu Thr Leu Leu Leu Ser Ala Tyr Lys Leu Cys Arg Phe Phe 
1               5                   10                  15      


Ala Met Ser Gly Pro Arg Pro Gly Ala Glu Arg Leu Ala Val Pro Gly 
            20                  25                  30          


Pro Asp Gly Gly Gly Gly Thr Gly Pro Trp Trp Ala Ala Gly Gly Arg 
        35                  40                  45              


Gly Pro Arg Glu Val Ser Pro Gly Ala Gly Thr Glu Val Gln Asp Ala 
    50                  55                  60                  


Leu Glu Arg Ala Leu Pro Glu Leu Gln Gln Ala Leu Ser Ala Leu Lys 
65                  70                  75                  80  


Gln Ala Gly Gly Ala Arg Ala Val Gly Ala Gly Leu Ala Glu Val Phe 
                85                  90                  95      


Gln Leu Val Glu Glu Ala Trp Leu Leu Pro Ala Val Gly Arg Glu Val 
            100                 105                 110         


Ala Gln Gly Leu Cys Asp Ala Ile Arg Leu Asp Gly Gly Leu Asp Leu 
        115                 120                 125             


Leu Leu Arg Leu Leu Gln Ala Pro Glu Leu Glu Thr Arg Val Gln Ala 
    130                 135                 140                 


Ala Arg Leu Leu Glu Gln Ile Leu Val Ala Glu Asn Arg Asp Arg Val 
145                 150                 155                 160 


Ala Arg Ile Gly Leu Gly Val Ile Leu Asn Leu Ala Lys Glu Arg Glu 
                165                 170                 175     


Pro Val Glu Leu Ala Arg Ser Val Ala Gly Ile Leu Glu His Met Phe 
            180                 185                 190         


Arg His Ser Glu Glu Thr Cys Gln Arg Leu Val Ala Ala Gly Gly Leu 
        195                 200                 205             


Asp Ala Val Leu Tyr Trp Cys Arg Arg Thr Asp Pro Ala Leu Leu Arg 
    210                 215                 220                 


His Cys Ala Leu Ala Leu Gly Asn Cys Ala Leu His Gly Gly Gln Ala 
225                 230                 235                 240 


Val Gln Arg Arg Met Val Glu Lys Arg Ala Ala Glu Trp Leu Phe Pro 
                245                 250                 255     


Leu Ala Phe Ser Lys Glu Asp Glu Leu Leu Arg Leu His Ala Cys Leu 
            260                 265                 270         


Ala Val Ala Val Leu Ala Thr Asn Lys Glu Val Glu Arg Glu Val Glu 
        275                 280                 285             


Arg Ser Gly Thr Leu Ala Leu Val Glu Pro Leu Val Ala Ser Leu Asp 
    290                 295                 300                 


Pro Gly Arg Phe Ala Arg Cys Leu Val Asp Ala Ser Asp Thr Ser Gln 
305                 310                 315                 320 


Gly Arg Gly Pro Asp Asp Leu Gln Arg Leu Val Pro Leu Leu Asp Ser 
                325                 330                 335     


Asn Arg Leu Glu Ala Gln Cys Ile Gly Ala Phe Tyr Leu Cys Ala Glu 
            340                 345                 350         


Ala Ala Ile Lys Ser Leu Gln Gly Lys Thr Lys Val Phe Ser Asp Ile 
        355                 360                 365             


Gly Ala Ile Gln Ser Leu Lys Arg Leu Val Ser Tyr Ser Thr Asn Gly 
    370                 375                 380                 


Thr Lys Ser Ala Leu Ala Lys Arg Ala Leu Arg Leu Leu Gly Glu Glu 
385                 390                 395                 400 


Val Pro Arg Pro Ile Leu Pro Ser Val Pro Ser Trp Lys Glu Ala Glu 
                405                 410                 415     


Val Gln Thr Trp Leu Gln Gln Ile Gly Phe Ser Lys Tyr Cys Glu Ser 
            420                 425                 430         


Phe Arg Glu Gln Gln Val Asp Gly Asp Leu Leu Leu Arg Leu Thr Glu 
        435                 440                 445             


Glu Glu Leu Gln Thr Asp Leu Gly Met Lys Ser Gly Ile Thr Arg Lys 
    450                 455                 460                 


Arg Phe Phe Arg Glu Leu Thr Glu Leu Lys Thr Phe Ala Asn Tyr Ser 
465                 470                 475                 480 


Thr Cys Asp Arg Ser Asn Leu Ala Asp Trp Leu Gly Ser Leu Asp Pro 
                485                 490                 495     


Arg Phe Arg Gln Tyr Thr Tyr Gly Leu Val Ser Cys Gly Leu Asp Arg 
            500                 505                 510         


Ser Leu Leu His Arg Val Ser Glu Gln Gln Leu Leu Glu Asp Cys Gly 
        515                 520                 525             


Ile His Leu Gly Val His Arg Ala Arg Ile Leu Thr Ala Ala Arg Glu 
    530                 535                 540                 


Met Leu His Ser Pro Leu Pro Cys Thr Gly Gly Lys Pro Ser Gly Asp 
545                 550                 555                 560 


Thr Pro Asp Val Phe Ile Ser Tyr Arg Arg Asn Ser Gly Ser Gln Leu 
                565                 570                 575     


Ala Ser Leu Leu Lys Val His Leu Gln Leu His Gly Phe Ser Val Phe 
            580                 585                 590         


Ile Asp Val Glu Lys Leu Glu Ala Gly Lys Phe Glu Asp Lys Leu Ile 
        595                 600                 605             


Gln Ser Val Met Gly Ala Arg Asn Phe Val Leu Val Leu Ser Pro Gly 
    610                 615                 620                 


Ala Leu Asp Lys Cys Met Gln Asp His Asp Cys Lys Asp Trp Val His 
625                 630                 635                 640 


Lys Ala Ile Val Thr Ala Leu Ser Cys Gly Lys Asn Ile Val Pro Ile 
                645                 650                 655     


Ile Asp Gly Phe Glu Trp Pro Glu Pro Gln Val Leu Pro Glu Asp Met 
            660                 665                 670         


Gln Ala Val Leu Thr Phe Asn Gly Ile Lys Trp Ser Ala Glu Tyr Gln 
        675                 680                 685             


Glu Ala Thr Ile Glu Lys Ile Ile Arg Phe Leu Gln Gly Arg Ser Ser 
    690                 695                 700                 


Arg Asp Ser Ser Ala Gly Ser Asp Thr Ser Leu Glu Gly Ala Ala Pro 
705                 710                 715                 720 


Met Gly Pro Thr 
                


<210>  15
<211>  2172
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SYNTHESIZED

<400>  15
atggtcctga cgctgcttct ctccgcctac aagctgtgtc gcttcttcgc catgtcgggc       60

ccacggccgg gcgccgagcg gctggcggtg cctgggccag atgggggcgg tggcacgggc      120

ccatggtggg ctgcgggtgg ccgcgggccc cgcgaagtgt cgccgggggc aggcaccgag      180

gtgcaggacg ccctggagcg cgcgctgccg gagctgcagc aggccttgtc cgcgctgaag      240

caggcgggcg gcgcgcgggc cgtgggcgcc ggcctggccg aggtcttcca actggtggag      300

gaggcctggc tgctgccggc cgtgggccgc gaggtagccc agggtctgtg cgacgccatc      360

cgcctcgatg gcggcctcga cctgctgttg cggctgctgc aggcgccgga gttggagacg      420

cgtgtgcagg ccgcgcgcct gctggagcag atcctggtgg ctgagaaccg agaccgcgtg      480

gcgcgcattg ggctgggcgt gatcctgaac ctggcgaagg aacgcgaacc cgtagagctg      540

gcgcggagcg tggcaggcat cttggagcac atgttccggc attcggagga gacatgccag      600

aggctggtgg cggccggcgg cctggacgcg gtgctgtatt ggtgccgccg cacggacccc      660

gcgctgctgc gccactgcgc gctggcgctg ggcaactgcg cgctgcacgg gggccaggcg      720

gtgcagcgac gcatggtaga gaagcgcgca gccgagtggc tcttcccgct cgccttctcc      780

aaggaggacg agctgcttcg gctgcacgcc tgcctcgcag tagcggtgtt ggcgactaac      840

aaggaggtgg agcgcgaggt ggagcgctcg ggcacgctgg cgctcgtgga gccgcttgtg      900

gcctcgctgg accctggccg cttcgcccgc tgtctggtgg acgccagcga cacaagccag      960

ggccgcgggc ccgacgacct gcagcgcctc gtgccgttgc tcgactctaa ccgcttggag     1020

gcgcagtgca tcggggcttt ctacctctgc gccgaggctg ccatcaagag cctgcaaggc     1080

aagaccaagg tgttcagcga catcggcgcc atccagagcc tgaaacgcct ggtttcctac     1140

tctaccaatg gcactaagtc ggcgctggcc aagcgcgcgc tgcgcctgct gggcgaggag     1200

gtgccacggc ccatcctgcc ctccgtgccc agctggaagg aggccgaggt tcagacgtgg     1260

ctgcagcaga tcggtttctc caagtactgc gagagcttcc gggagcagca ggtggatggc     1320

gacctgcttc tgcggctcac ggaggaggaa ctccagaccg acctgggcat gaaatcgggc     1380

atcacccgca agaggttctt tagggagctc acggagctca agaccttcgc caactattct     1440

acgtgcgacc gcagcaacct ggcggactgg ctgggcagcc tggacccgcg cttccgccag     1500

tacacctacg gcctggtcag ctgcggcctg gaccgctccc tgctgcaccg cgtgtctgag     1560

cagcagctgc tggaagactg cggcatccac ctgggcgtgc accgcgcccg catcctcacg     1620

gcggccagag aaatgctaca ctccccgctg ccctgtactg gtggcaaacc cagtggggac     1680

actccagatg tcttcatcag ctaccgccgg aactcaggtt cccagctggc cagtctcctg     1740

aaggtgcacc tgcagctgca tggcttcagt gtcttcattg atgtggagaa gctggaagca     1800

ggcaagttcg aggacaaact catccagagt gtcatgggtg cccgcaactt tgtgttggtg     1860

ctatcacctg gagcactgga caagtgcatg caagaccatg actgcaagga ttgggtgcat     1920

aaggagattg tgactgcttt aagctgcggc aagaacattg tgcccatcat tgatggcttc     1980

gagtggcctg agccccaggt cctgcctgag gacatgcagg ctgtgcttac tttcaacggt     2040

atcaagtggt ccgccgaata ccaggaggcc accattgaga agatcatccg cttcctgcag     2100

ggccgctcct cccgggactc atctgcaggc tctgacacca gtttggaggg tgctgcaccc     2160

atgggtccaa cc                                                         2172


