                               SEQUENCE LISTING

<110> DICERNA PHARMACEUTICALS, INC.
 
<120> BETA CATENIN NUCLEIC ACID INHIBITOR MOLECULE 

<130> 0243.0008-PCT

<140>
<141>

<150> 62/573,999
<151> 2017-10-18

<160> 14

<170> PatentIn version 3.5

<210> 1
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> RNA base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (3)..(3)
<223> RNA base 

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (7)..(7)
<223> RNA base 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (9)..(11)
<223> RNA base 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (13)..(13)
<223> RNA base 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (15)..(15)
<223> RNA base 

<220>
<221> modified_base
<222> (16)..(18)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (19)..(23)
<223> RNA base

<220>
<221> modified_base
<222> (24)..(25)
<223> DNA base 

<400> 1
agaauacaaa ugauguagaa acagc                                             25


<210> 2
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (5)..(8)
<223> RNA base 

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (10)..(10)
<223> RNA base 

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (12)..(12)
<223> RNA base 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (14)..(14)
<223> RNA base 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (16)..(20)
<223> RNA base

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (22)..(22)
<223> RNA base

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (24)..(24)
<223> RNA base

<220>
<221> modified_base
<222> (25)..(27)
<223> 2'Ome modified base

<400> 2
gcuguuucua caucauuugu auucugc                                           27


<210> 3
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'F modified base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified base

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified base

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'F modified base

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified base

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified base

<220>
<221> modified_base
<222> (16)..(18)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (19)..(23)
<223> RNA base

<220>
<221> modified_base
<222> (24)..(25)
<223> DNA base

<400> 3
agaauacaaa ugauguagaa acagc                                             25


<210> 4
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (5)..(7)
<223> RNA base

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified base

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified base

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified base

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified base

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (16)..(19)
<223> RNA base 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'F modified base

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'F modified base

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'F modified base

<220>
<221> modified_base
<222> (25)..(27)
<223> 2'Ome modified base

<400> 4
gcuguuucua caucauuugu auucugc                                           27


<210> 5
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'F modified base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified base

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified base

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'F modified base

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified base

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified base

<220>
<221> modified_base
<222> (16)..(18)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (19)..(21)
<223> 2'F modified base

<220>
<221> modified_base
<222> (22)..(23)
<223> RNA base

<220>
<221> modified_base
<222> (24)..(25)
<223> DNA base

<400> 5
agaauacaaa ugauguagaa acagc                                             25


<210> 6
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(4)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (5)..(7)
<223> RNA base

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'F modified base

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'F modified base

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'F modified base

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'F modified base

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (16)..(18)
<223> RNA base 

<220>
<221> modified_base
<222> (19)..(20)
<223> 2'F modified base

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'F modified base

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'F modified base

<220>
<221> modified_base
<222> (25)..(27)
<223> 2'Ome modified base

<400> 6
gcuguuucua caucauuugu auucugc                                           27


<210> 7
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> RNA base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (3)..(3)
<223> RNA base 

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (7)..(7)
<223> RNA base 

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (9)..(11)
<223> RNA base 

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (13)..(13)
<223> RNA base 

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (15)..(15)
<223> RNA base 

<220>
<221> modified_base
<222> (16)..(18)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (19)..(23)
<223> RNA base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (25)..(26)
<223> DNA base 

<400> 7
agaauacaaa ugauguagaa acagcc                                            26


<210> 8
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'F modified base 

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified base 

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (10)..(10)
<223> DNA base 

<220>
<221> modified_base
<222> (11)..(15)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (16)..(19)
<223> RNA base 

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (21)..(21)
<223> RNA base 

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (23)..(23)
<223> RNA base 

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (25)..(25)
<223> RNA base 

<220>
<221> modified_base
<222> (26)..(26)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (27)..(31)
<223> RNA base

<220>
<221> modified_base
<222> (32)..(32)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (33)..(33)
<223> RNA base

<220>
<221> modified_base
<222> (34)..(34)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (35)..(35)
<223> RNA base

<220>
<221> modified_base
<222> (36)..(38)
<223> 2'Ome modified base

<400> 8
uagcuaucgt ggcuguuucu acaucauuug uauucugc                               38


<210> 9
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'F modified base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified base

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified base

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'F modified base

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified base

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified base

<220>
<221> modified_base
<222> (16)..(18)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (19)..(23)
<223> RNA base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (25)..(26)
<223> DNA base

<400> 9
agaauacaaa ugauguagaa acagcc                                            26


<210> 10
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'F modified base 

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified base 

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (10)..(10)
<223> DNA base 

<220>
<221> modified_base
<222> (11)..(15)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (16)..(18)
<223> RNA base

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified base

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'F modified base

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'F modified base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (25)..(25)
<223> 2'F modified base

<220>
<221> modified_base
<222> (26)..(26)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (27)..(30)
<223> RNA base 

<220>
<221> modified_base
<222> (31)..(31)
<223> 2'F modified base

<220>
<221> modified_base
<222> (32)..(32)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (33)..(33)
<223> 2'F modified base

<220>
<221> modified_base
<222> (34)..(34)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (35)..(35)
<223> 2'F modified base

<220>
<221> modified_base
<222> (36)..(38)
<223> 2'Ome modified base

<400> 10
uagcuaucgt ggcuguuucu acaucauuug uauucugc                               38


<210> 11
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'F modified base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'F modified base

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'F modified base

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (9)..(11)
<223> 2'F modified base

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'F modified base

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'F modified base

<220>
<221> modified_base
<222> (16)..(18)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (19)..(20)
<223> 2'F modified base

<220>
<221> modified_base
<222> (21)..(23)
<223> RNA base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (25)..(26)
<223> DNA base

<400> 11
agaauacaaa ugauguagaa acagcc                                            26


<210> 12
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'F modified base

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'F modified base

<220>
<221> modified_base
<222> (7)..(9)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (10)..(10)
<223> DNA base

<220>
<221> modified_base
<222> (11)..(15)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (16)..(18)
<223> RNA base

<220>
<221> modified_base
<222> (19)..(19)
<223> 2'F modified base

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'F modified base

<220>
<221> modified_base
<222> (22)..(22)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'F modified base

<220>
<221> modified_base
<222> (24)..(24)
<223> 2'Ome modified base

<220>
<221> modified_base
<222> (25)..(25)
<223> 2'F modified base

<220>
<221> modified_base
<222> (26)..(26)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (27)..(29)
<223> RNA base 

<220>
<221> modified_base
<222> (30)..(31)
<223> 2'F modified base

<220>
<221> modified_base
<222> (32)..(32)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (33)..(33)
<223> 2'F modified base

<220>
<221> modified_base
<222> (34)..(34)
<223> 2'Ome modified base 

<220>
<221> modified_base
<222> (35)..(35)
<223> 2'F modified base

<220>
<221> modified_base
<222> (36)..(38)
<223> 2'Ome modified base 

<400> 12
uagcuaucgt ggcuguuucu acaucauuug uauucugc                               38


<210> 13
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 13
agaauacaaa ugauguagaa acagcc                                            26


<210> 14
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 14
uagcuaucgt ggcuguuucu acaucauuug uauucugc                               38

