                         б

<110>  Ŵѧ
 
<120>  H3N2вѪص׵ͻ弰Ӧ

<130>  IEC170092PCT

<150>  CN 201710969146.0
<151>  2017-10-18

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  550
<212>  PRT
<213>  Influenza A virus

<400>  1

Gln Lys Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp 
            20                  25                  30          


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
        35                  40                  45              


Gly Gly Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln 
65                  70                  75                  80  


Asn Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Asn Asp Glu Ser Phe Asn Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Thr Ser Ser Ser Cys Lys Arg Arg Ser Asn 
    130                 135                 140                 


Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr Gln Leu Lys Phe Lys 
145                 150                 155                 160 


Tyr Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Lys Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Val Thr Asp Asn Asp Gln Ile 
            180                 185                 190         


Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile Thr Val Ser Thr Lys Arg 
        195                 200                 205             


Ser Gln Gln Thr Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg 
    210                 215                 220                 


Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Ile Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn Gly Lys Leu Asn Arg Leu 
    370                 375                 380                 


Ile Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  2
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WI2005-WT-HA

<400>  2

Met Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asp Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser 
        115                 120                 125             


Ser Cys Lys Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr Gln Leu Lys Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Val Thr Asp Asn Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Gly 
                485                 490                 495     


Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
            500                 505                 510         


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
        515                 520                 525             


Leu Ser Thr Phe Leu Gly His His His His His His 
    530                 535                 540 


<210>  3
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-mut1

<400>  3

Met Ala Thr Leu Cys Leu Gly His His Ala Val Pro Ala Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Ala Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Ala Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asp Glu Ser Phe Ala Trp Thr Gly Val Thr Gln Ala Gly Thr Ser Ser 
        115                 120                 125             


Ser Cys Lys Arg Arg Ser Ala Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr Gln Leu Lys Phe Lys Tyr Pro Ala Leu Ala Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Val Thr Asp Asn Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Ala Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Ala Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Ala Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Gly 
                485                 490                 495     


Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
            500                 505                 510         


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
        515                 520                 525             


Leu Ser Thr Phe Leu Gly His His His His His His 
    530                 535                 540 


<210>  4
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-mut2

<400>  4

Met Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Ala Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asp Glu Ser Phe Ala Trp Thr Gly Val Thr Gln Ala Gly Thr Ser Ser 
        115                 120                 125             


Ser Cys Lys Arg Arg Ser Ala Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr Gln Leu Lys Phe Lys Tyr Pro Ala Leu Ala Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Val Thr Asp Asn Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Ala Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Gly 
                485                 490                 495     


Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
            500                 505                 510         


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
        515                 520                 525             


Leu Ser Thr Phe Leu Gly His His His His His His 
    530                 535                 540 


<210>  5
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-mut3

<400>  5

Met Ala Thr Leu Cys Leu Gly His His Ala Val Pro Ala Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Ala Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asp Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser 
        115                 120                 125             


Ser Cys Lys Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr Gln Leu Lys Phe Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Val Thr Asp Asn Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg 
            180                 185                 190         


Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Ala Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Ala Gly Thr Tyr Asp His Asp 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Gly 
                485                 490                 495     


Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
            500                 505                 510         


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
        515                 520                 525             


Leu Ser Thr Phe Leu Gly His His His His His His 
    530                 535                 540 


<210>  6
<211>  565
<212>  PRT
<213>  Influenza A virus

<400>  6

Lys Thr Ile Ile Ala Leu Ser Tyr Ile Leu Cys Leu Val Phe Ala Gln 
1               5                   10                  15      


Lys Ile Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly His 
            20                  25                  30          


His Ala Val Pro Asn Gly Thr Ile Val Lys Thr Ile Thr Asn Asp Arg 
        35                  40                  45              


Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Asn Ser Ser Ile Gly 
    50                  55                  60                  


Glu Ile Cys Asp Ser Pro His Gln Ile Leu Asp Gly Glu Asn Cys Thr 
65                  70                  75                  80  


Leu Ile Asp Ala Leu Leu Gly Asp Pro Gln Cys Asp Gly Phe Gln Asn 
                85                  90                  95      


Lys Lys Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Tyr Ser Asn Cys 
            100                 105                 110         


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val Ala 
        115                 120                 125             


Ser Ser Gly Thr Leu Glu Phe Asn Asn Glu Ser Phe Asn Trp Thr Gly 
    130                 135                 140                 


Val Thr Gln Asn Gly Thr Ser Ser Ala Cys Ile Arg Arg Ser Ser Ser 
145                 150                 155                 160 


Ser Phe Phe Ser Arg Leu Asn Trp Leu Thr His Leu Asn Tyr Lys Tyr 
                165                 170                 175     


Pro Ala Leu Asn Val Thr Met Pro Asn Asn Glu Gln Phe Asp Lys Leu 
            180                 185                 190         


Tyr Ile Trp Gly Val His His Pro Gly Thr Asp Lys Asp Gln Ile Phe 
        195                 200                 205             


Pro Tyr Ala Gln Ser Ser Gly Arg Ile Ile Val Ser Thr Lys Arg Ser 
    210                 215                 220                 


Gln Gln Ala Val Ile Pro Asn Ile Gly Ser Arg Pro Arg Ile Arg Asp 
225                 230                 235                 240 


Ile Pro Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly Asp 
                245                 250                 255     


Ile Leu Leu Ile Asn Ser Thr Gly Asn Leu Ile Ala Pro Arg Gly Tyr 
            260                 265                 270         


Phe Lys Leu Arg Ser Gly Lys Ser Ser Ile Met Arg Ser Asp Ala Pro 
        275                 280                 285             


Ile Gly Lys Cys Lys Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile Pro 
    290                 295                 300                 


Asn Asp Lys Pro Phe Gln Asn Val Asn Arg Ile Thr Tyr Gly Ala Cys 
305                 310                 315                 320 


Pro Arg Tyr Val Lys His Ser Thr Leu Lys Leu Ala Thr Gly Met Arg 
                325                 330                 335     


Asn Val Pro Glu Lys Gln Thr Arg Gly Ile Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Asn Gly Trp Glu Gly Met Val Asp Gly Trp Tyr Gly Phe 
        355                 360                 365             


Arg His Gln Asn Ser Glu Gly Arg Gly Gln Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Leu Ile 
385                 390                 395                 400 


Gly Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser Glu 
                405                 410                 415     


Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr Lys 
            420                 425                 430         


Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu Asn 
        435                 440                 445             


Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe Glu 
    450                 455                 460                 


Lys Thr Lys Lys Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Gly Ser Ile 
                485                 490                 495     


Arg Asn Gly Thr Tyr Asp His Asn Val Tyr Arg Asp Glu Ala Leu Asn 
            500                 505                 510         


Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys Asp 
        515                 520                 525             


Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys Val 
    530                 535                 540                 


Ala Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Lys Gly Asn Ile Arg 
545                 550                 555                 560 


Cys Asn Ile Cys Ile 
                565 


<210>  7
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK2014-WT-HA

<400>  7

Met Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Asn Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser Ser 
        115                 120                 125             


Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr His Leu Asn Tyr Lys Tyr Pro Ala Leu Asn Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Gly Thr Asp Lys Asp Gln Ile Phe Pro Tyr Ala Gln Ser Ser Gly Arg 
            180                 185                 190         


Ile Ile Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Leu Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His Asn 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Gly 
                485                 490                 495     


Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
            500                 505                 510         


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
        515                 520                 525             


Leu Ser Thr Phe Leu Gly His His His His His His 
    530                 535                 540 


<210>  8
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HK2014-DG-HA

<400>  8

Met Ala Thr Leu Cys Leu Gly His His Ala Val Pro Gln Gly Thr Ile 
1               5                   10                  15      


Val Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Gln Ala Thr Glu 
            20                  25                  30          


Leu Val Gln Gln Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His Gln 
        35                  40                  45              


Ile Leu Asp Gly Glu Gln Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp 
    50                  55                  60                  


Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu 
65                  70                  75                  80  


Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
                85                  90                  95      


Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn 
            100                 105                 110         


Gln Glu Ser Phe Gln Trp Thr Gly Val Thr Gln Gln Gly Thr Ser Ser 
        115                 120                 125             


Ala Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn Trp 
    130                 135                 140                 


Leu Thr His Leu Asn Tyr Lys Tyr Pro Ala Leu Gln Val Thr Met Pro 
145                 150                 155                 160 


Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro 
                165                 170                 175     


Gly Thr Asp Lys Asp Gln Ile Phe Pro Tyr Ala Gln Ser Ser Gly Arg 
            180                 185                 190         


Ile Ile Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Gln Ser Thr Gly 
225                 230                 235                 240 


Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Leu Arg Ser Gly Lys Ser 
                245                 250                 255     


Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu Cys 
            260                 265                 270         


Ile Thr Pro Gln Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val 
        275                 280                 285             


Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg 
305                 310                 315                 320 


Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg 
            340                 345                 350         


Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile 
        355                 360                 365             


Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His 
    370                 375                 380                 


Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu 
385                 390                 395                 400 


Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp 
            420                 425                 430         


Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys 
    450                 455                 460                 


Asp Asn Ala Cys Ile Gly Ser Ile Arg Gln Gly Thr Tyr Asp His Asn 
465                 470                 475                 480 


Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Ser Gly 
                485                 490                 495     


Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro Glu Ala 
            500                 505                 510         


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
        515                 520                 525             


Leu Ser Thr Phe Leu Gly His His His His His His 
    530                 535                 540 


<210>  9
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ź

<400>  9

Met Leu Leu Val Asn Gln Ser His Gln Gly Phe Asn Lys Glu His Thr 
1               5                   10                  15      


Ser Lys Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala 
            20                  25                  30          


Ala His Ser Ala Phe Ala 
        35              


<210>  10
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ۵

<400>  10

Ser Gly Arg Leu Val Pro Arg Gly Ser Pro Gly Ser Gly Tyr Ile Pro 
1               5                   10                  15      


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
            20                  25                  30          


Val Leu Leu Ser Thr Phe Leu Gly 
        35                  40  


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hisǩ

<400>  11

His His His His His His 
1               5       


<210>  12
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  вA/WISCONSIN/67/2005 (H3N2)HA׵ͻ

<400>  12

Ala Thr Leu Cys Leu Gly His His Ala Val Pro Ala Gly Thr Ile Val 
1               5                   10                  15      


Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Ala Ala Thr Glu Leu 
            20                  25                  30          


Val Gln Ser Ser Ser Thr Gly Gly Ile Cys Asp Ser Pro His Gln Ile 
        35                  40                  45              


Leu Asp Gly Glu Ala Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro 
    50                  55                  60                  


Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu Arg 
65                  70                  75                  80  


Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn Asp 
            100                 105                 110         


Glu Ser Phe Ala Trp Thr Gly Val Thr Gln Ala Gly Thr Ser Ser Ser 
        115                 120                 125             


Cys Lys Arg Arg Ser Ala Asn Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr Gln Leu Lys Phe Lys Tyr Pro Ala Leu Ala Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Lys Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Val 
                165                 170                 175     


Thr Asp Asn Asp Gln Ile Phe Leu Tyr Ala Gln Ala Ser Gly Arg Ile 
            180                 185                 190         


Thr Val Ser Thr Lys Arg Ser Gln Gln Thr Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Ala Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Ala Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Asn Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Ile Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asn Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Arg Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Ala Gly Thr Tyr Asp His Asp Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys 
                485                 490             


<210>  13
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  вA/HONG_KONG/4801/2014(H3N2)HA׵ͻ

<400>  13

Ala Thr Leu Cys Leu Gly His His Ala Val Pro Gln Gly Thr Ile Val 
1               5                   10                  15      


Lys Thr Ile Thr Asn Asp Arg Ile Glu Val Thr Gln Ala Thr Glu Leu 
            20                  25                  30          


Val Gln Gln Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His Gln Ile 
        35                  40                  45              


Leu Asp Gly Glu Gln Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro 
    50                  55                  60                  


Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val Glu Arg 
65                  70                  75                  80  


Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Asn Gln 
            100                 105                 110         


Glu Ser Phe Gln Trp Thr Gly Val Thr Gln Gln Gly Thr Ser Ser Ala 
        115                 120                 125             


Cys Ile Arg Arg Ser Ser Ser Ser Phe Phe Ser Arg Leu Asn Trp Leu 
    130                 135                 140                 


Thr His Leu Asn Tyr Lys Tyr Pro Ala Leu Gln Val Thr Met Pro Asn 
145                 150                 155                 160 


Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His Pro Gly 
                165                 170                 175     


Thr Asp Lys Asp Gln Ile Phe Pro Tyr Ala Gln Ser Ser Gly Arg Ile 
            180                 185                 190         


Ile Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn Ile Gly 
        195                 200                 205             


Ser Arg Pro Arg Ile Arg Asp Ile Pro Ser Arg Ile Ser Ile Tyr Trp 
    210                 215                 220                 


Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Gln Ser Thr Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Arg Gly Tyr Phe Lys Leu Arg Ser Gly Lys Ser Ser 
                245                 250                 255     


Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Lys Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Gln Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys His Ser Thr Leu 
    290                 295                 300                 


Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr Arg Gly 
305                 310                 315                 320 


Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Met 
                325                 330                 335     


Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly Arg Gly 
            340                 345                 350         


Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe His Gln 
    370                 375                 380                 


Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp Leu Glu 
385                 390                 395                 400 


Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr Asp Ser 
            420                 425                 430         


Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys Cys Asp 
    450                 455                 460                 


Asn Ala Cys Ile Gly Ser Ile Arg Gln Gly Thr Tyr Asp His Asn Val 
465                 470                 475                 480 


Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys 
                485                 490             


