                         SEQUENCE LISTING

<110>  Board of Regents, The University of Texas System
       Lizee, Gregory
       Yee, Cassian
 
<120>  T CELL RECEPTORS FOR IMMUNOTHERAPY

<130>  UTFC.P1314WO

<150>  62571447
<151>  2017-10-12

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 alpha chain

<400>  1
atggagaaga atcctttggc agccccatta ctaatcctct ggtttcatct tgactgcgtg       60

agcagcatac tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc      120

accaatttca cctgcagctt cccttccagc aatttttatg ccttacactg gtacagatgg      180

gaaactgcaa aaagccccga ggccttgttt gtaatgactt taaatgggga tgaaaagaag      240

aaaggacgaa taagtgccac tcttaatacc aaggagggtt acagctattt gtacatcaaa      300

ggatcccagc ctgaagactc agccacatac ctctgtgcct ttttgtcgaa taacaatgcc      360

agactcatgt ttggagatgg aactcagctg gtggtgaagc ccaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaaactgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagctaa                   828


<210>  2
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 alpha chain

<400>  2

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Phe Leu Ser Asn Asn Asn Ala Arg Leu Met Phe Gly Asp Gly Thr 
        115                 120                 125             


Gln Leu Val Val Lys Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser 
        275 


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 alpha chain CDR1

<400>  3

Ser Ser Asn Phe Tyr Ala 
1               5       


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 alpha chain CDR2

<400>  4

Met Thr Leu Asn Gly Asp Glu 
1               5           


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 alpha chain CDR3

<400>  5

Ala Phe Leu Ser Asn Asn Asn Ala Arg Leu Met 
1               5                   10      


<210>  6
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 beta chain

<400>  6
atgcttagtc ctgacctgcc tgactctgcc tggaacacca ggctcctctg ccatgtcatg       60

ctttgtctcc tgggagcagg ttcagtggct gctggagtca tccagtcccc aagacatctg      120

atcaaagaaa agagggaaac agccactctg aaatgctatc ctatccctag acacgacact      180

gtctactggt accagcaggg tccaggtcag gacccccagt tcctcatttc gttttatgaa      240

aagatgcaga gcgataaagg aagcatccct gatcgattct cagctcaaca gttcagtgac      300

tatcattctg aactgaacat gagctccttg gagctggggg actcagccct gtacttctgt      360

gccagcagct tatggggcag ccataattca cccctccact ttgggaacgg gaccaggctc      420

actgtgacag aggacctgaa caaggtgttc ccacccgagg tcgctgtgtt tgagccatca      480

gaagcagaga tctcccacac ccaaaaggcc acactggtgt gcctggccac aggcttcttc      540

cccgaccacg tggagctgag ctggtgggtg aatgggaagg aggtgcacag tggggtcagc      600

acggacccgc agcccctcaa ggagcagccc gccctcaatg actccagata ctgcctgagc      660

agccgcctga gggtctcggc caccttctgg cagaaccccc gcaaccactt ccgctgtcaa      720

gtccagttct acgggctctc ggagaatgac gagtggaccc aggatagggc caaacccgtc      780

acccagatcg tcagcgccga ggcctggggt agagcagact gtggctttac ctcggtgtcc      840

taccagcaag gggtcctgtc tgccaccatc ctctatgaga tcctgctagg gaaggccacc      900

ctgtatgctg tgctggtcag cgcccttgtg ttgatggcca tggtcaagag aaaggatttc      960

taa                                                                    963


<210>  7
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 beta chain

<400>  7

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Gly Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Leu Trp Gly Ser His 
        115                 120                 125             


Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg Leu Thr Val Thr Glu 
    130                 135                 140                 


Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
145                 150                 155                 160 


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                165                 170                 175     


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            180                 185                 190         


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
        195                 200                 205             


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
    210                 215                 220                 


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
225                 230                 235                 240 


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
                245                 250                 255     


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
            260                 265                 270         


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
        275                 280                 285             


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
    290                 295                 300                 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
305                 310                 315                 320 


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 beta chain CDR1

<400>  8

Pro Arg His Asp Thr 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 beta chain CDR2

<400>  9

Phe Tyr Glu Lys Met Gln 
1               5       


<210>  10
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #24 beta chain CDR3

<400>  10

Cys Ala Ser Ser Leu Trp Gly Ser His Asn Ser Pro Leu 
1               5                   10              


<210>  11
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Alpha chain

<400>  11
atggaaactc tcctgggagt gtctttggtg attctatggc ttcaactggc tagggtgaac       60

agtcaacagg gagaagagga tcctcaggcc ttgagcatcc aggagggtga aaatgccacc      120

atgaactgca gttacaaaac tagtataaac aatttacagt ggtatagaca aaattcaggt      180

agaggccttg tccacctaat tttaatacgt tcaaatgaaa gagagaaaca cagtggaaga      240

ttaagagtca cgcttgacac ttccaagaaa agcagttcct tgttgatcac ggcttcccgg      300

gcagcagaca ctgcttctta cttctgtgct acggacgata atgcaggcaa catgctcacc      360

tttggagggg gaacaaggtt aatggtcaaa ccccatatcc agaaccctga ccctgccgtg      420

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat      480

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg      540

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct      600

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc      660

agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac      720

ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg      780

tttaatctgc tcatgacgct gcggctgtgg tccagctaa                             819


<210>  12
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Alpha chain

<400>  12

Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Asp Asn Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met 
        115                 120                 125             


Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Alpha chain CDR1

<400>  13

Thr Ser Ile Asn Asn 
1               5   


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Alpha chain CDR2

<400>  14

Ile Arg Ser Asn Glu Arg Glu 
1               5           


<210>  15
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Alpha chain CDR3

<400>  15

Ala Thr Asp Asp Asn Ala Gly Asn Met Leu Thr 
1               5                   10      


<210>  16
<211>  924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Beta chain

<400>  16
atgggaatca ggctcctctg tcgtgtggcc ttttgtttcc tggctgtagg cctcgtagat       60

gtgaaagtaa cccagagctc gagatatcta gtcaaaagga cgggagagaa agtttttctg      120

gaatgtgtcc aggatatgga ccatgaaaat atgttctggt atcgacaaga cccaggtctg      180

gggctacggc tgatctattt ctcatatgat gttaaaatga aagaaaaagg agatattcct      240

gaggggtaca gtgtctctag agagaagaag gagcgcttct ccctgattct ggagtccgcc      300

agcaccaacc agacatctat gtacctctgt gccagcagtt ttaccccaga tacgcagtat      360

tttggcccag gcacccggct gacagtgctc gaggacctga aaaacgtgtt cccacccgag      420

gtcgctgtgt ttgagccatc agaagcagag atctcccaca cccaaaaggc cacactggtg      480

tgcctggcca caggcttcta ccccgaccac gtggagctga gctggtgggt gaatgggaag      540

gaggtgcaca gtggggtcag cacagacccg cagcccctca aggagcagcc cgccctcaat      600

gactccagat actgcctgag cagccgcctg agggtctcgg ccaccttctg gcagaacccc      660

cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga cgagtggacc      720

caggataggg ccaaacctgt cacccagatc gtcagcgccg aggcctgggg tagagcagac      780

tgtggcttca cctccgagtc ttaccagcaa ggggtcctgt ctgccaccat cctctatgag      840

atcttgctag ggaaggccac cttgtatgcc gtgctggtca gtgccctcgt gctgatggcc      900

atggtcaaga gaaaggattt ctaa                                             924


<210>  17
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Beta chain

<400>  17

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Thr Pro Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
    130                 135                 140                 


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
            180                 185                 190         


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
225                 230                 235                 240 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asp Phe 
305         


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Beta chain CDR1

<400>  18

Met Asp His Glu Asn 
1               5   


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Beta chain CDR2

<400>  19

Ser Tyr Asp Val Lys Met 
1               5       


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #39 Beta chain CDR3

<400>  20

Ala Ser Ser Phe Thr Pro Asp Thr Gln Tyr 
1               5                   10  


<210>  21
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 alpha chain

<400>  21
atggagaccc tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctc      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggtctca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gataatcaaa ctggggcaaa caacctcttc      360

tttgggactg gaacgagact caccgttatt ccctatatcc agaaccctga ccctgccgtg      420

taccagctga gagactctaa atccagtgac aagtctgtct gcctattcac cgattttgat      480

tctcaaacaa atgtgtcaca aagtaaggat tctgatgtgt atatcacaga caaaactgtg      540

ctagacatga ggtctatgga cttcaagagc aacagtgctg tggcctggag caacaaatct      600

gactttgcat gtgcaaacgc cttcaacaac agcattattc cagaagacac cttcttcccc      660

agcccagaaa gttcctgtga tgtcaagctg gtcgagaaaa gctttgaaac agatacgaac      720

ctaaactttc aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg      780

tttaatctgc tcatgacgct gcggctgtgg tccagc                                816


<210>  22
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 alpha chain

<400>  22

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Asp Asn 
            100                 105                 110         


Gln Thr Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Ile Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
    130                 135                 140                 


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
            180                 185                 190         


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
        195                 200                 205             


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
    210                 215                 220                 


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 alpha chain CDR1

<400>  23

Asp Ser Ala Ile Tyr Asn 
1               5       


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 alpha chain CDR2

<400>  24

Ile Gln Ser Ser Gln Arg Glu 
1               5           


<210>  25
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 alpha chain CDR3

<400>  25

Ala Asp Asn Gln Thr Gly Ala Asn Asn Leu Phe 
1               5                   10      


<210>  26
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 beta chain

<400>  26
atgcttagtc ctgacctgcc tgactctgcc tggaacacca ggctcctctg ccatgtcatg       60

ctttgtctcc tgggagcagg ttcagtggct gctggagtca tccagtcccc aagacatctg      120

atcaaagaaa agagggaaac agccactctg aaatgctatc ctatccctag acacgacact      180

gtctactggt accagcaggg tccaggtcag gacccccagt tcctcatttc gttttatgaa      240

aagatgcaga gcgataaagg aagcatccct gatcgattct cagctcaaca gttcagtgac      300

tatcattctg aactgaacat gagctccttg gagctggggg actcagccct gtacttctgt      360

gccagcagcg agggggggta tggaaactat ggctacacct tcggttcggg gaccaggtta      420

accgttgtag aggacctgaa caaggtgttc ccacccgagg tcgctgtgtt tgagccatca      480

gaagcagaga tctcccacac ccaaaaggcc acactggtgt gcctggccac aggcttcttc      540

cccgaccacg tggagctgag ctggtgggtg aatgggaagg aggtgcacag tggggtcagc      600

acggacccgc agcccctcaa ggagcagccc gccctcaatg actccagata ctgcctgagc      660

agccgcctga gggtctcggc caccttctgg cagaaccccc gcaaccactt ccgctgtcaa      720

gtccagttct acgggctctc ggagaatgac gagtggaccc aggatagggc caaacccgtc      780

acccagatcg tcagcgccga ggcctggggt agagcagact gtggctttac ctcggtgtcc      840

taccagcaag gggtcctgtc tgccaccatc ctctatgaga tcctgctagg gaaggccacc      900

ctgtatgctg tgctggtcag cgcccttgtg ttgatggcca tggtcaagag aaaggatttc      960

taa                                                                    963


<210>  27
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 beta chain

<400>  27

Met Leu Ser Pro Asp Leu Pro Asp Ser Ala Trp Asn Thr Arg Leu Leu 
1               5                   10                  15      


Cys His Val Met Leu Cys Leu Leu Gly Ala Gly Ser Val Ala Ala Gly 
            20                  25                  30          


Val Ile Gln Ser Pro Arg His Leu Ile Lys Glu Lys Arg Glu Thr Ala 
        35                  40                  45              


Thr Leu Lys Cys Tyr Pro Ile Pro Arg His Asp Thr Val Tyr Trp Tyr 
    50                  55                  60                  


Gln Gln Gly Pro Gly Gln Asp Pro Gln Phe Leu Ile Ser Phe Tyr Glu 
65                  70                  75                  80  


Lys Met Gln Ser Asp Lys Gly Ser Ile Pro Asp Arg Phe Ser Ala Gln 
                85                  90                  95      


Gln Phe Ser Asp Tyr His Ser Glu Leu Asn Met Ser Ser Leu Glu Leu 
            100                 105                 110         


Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Glu Gly Gly Tyr Gly 
        115                 120                 125             


Asn Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val Glu 
    130                 135                 140                 


Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
145                 150                 155                 160 


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
                165                 170                 175     


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
            180                 185                 190         


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
        195                 200                 205             


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
    210                 215                 220                 


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
225                 230                 235                 240 


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
                245                 250                 255     


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
            260                 265                 270         


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
        275                 280                 285             


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
    290                 295                 300                 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
305                 310                 315                 320 


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 beta chain CDR1

<400>  28

Pro Arg His Asp Thr 
1               5   


<210>  29
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 beta chain CDR2

<400>  29

Phe Tyr Glu Lys Met Gln 
1               5       


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone #76 beta chain CDR3

<400>  30

Ala Ser Ser Glu Gly Gly Tyr Gly Asn Tyr Gly Tyr Thr 
1               5                   10              


<210>  31
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Alpha chain

<400>  31
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgagagaggg ctggggcttt      360

ggaaatgaga aattaacctt tgggactgga acaagactca ccatcatacc caatatccag      420

aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc      480

ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat      540

atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg      600

gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca      660

gaagacacct tcttccccag cccagaaagt tcctgtgatg tcaagctggt cgagaaaagc      720

tttgaaacag atacgaacct aaactttcaa aacctgtcag tgattgggtt ccgaatcctc      780

ctcctgaaag tggccgggtt taatctgctc atgacgctgc ggctgtggtc cagctaa         837


<210>  32
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Alpha chain CDR1

<400>  32

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Gly Trp Gly Phe Gly Asn Glu Lys Leu Thr Phe Gly 
        115                 120                 125             


Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp 
                165                 170                 175     


Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met 
            180                 185                 190         


Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe 
        195                 200                 205             


Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe 
    210                 215                 220                 


Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
                245                 250                 255     


Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser 
        275             


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Alpha chain CDR1

<400>  33

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Alpha chain CDR2

<400>  34

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Alpha chain CDR3

<400>  35

Ala Met Arg Glu Gly Trp Gly Phe Gly Asn Glu Lys Leu Thr 
1               5                   10                  


<210>  36
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Beta chain

<400>  36
atgggaatca ggctcctctg tcgtgtggcc ttttgtttcc tggctgtagg cctcgtagat       60

gtgaaagtaa cccagagctc gagatatcta gtcaaaagga cgggagagaa agtttttctg      120

gaatgtgtcc aggatatgga ccatgaaaat atgttctggt atcgacaaga cccaggtctg      180

gggctacggc tgatctattt ctcatatgat gttaaaatga aagaaaaagg agatattcct      240

gaggggtaca gtgtctctag agagaagaag gagcgcttct ccctgattct ggagtccgcc      300

agcaccaacc agacatctat gtacctctgt gccagcagag agaagcgggg ggaagacaca      360

gatacgcagt attttggccc aggcacccgg ctgacagtgc tcgaggacct gaaaaacgtg      420

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag      480

gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg      540

gtgaatggga aggaggtgca cagtggggtc agcacagacc cgcagcccct caaggagcag      600

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc      660

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat      720

gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg      780

ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc      840

atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc      900

gtgctgatgg ccatggtcaa gagaaaggat tcctaa                                936


<210>  37
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Beta chain

<400>  37

Met Gly Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Arg Glu Lys Arg Gly Glu Asp Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
    130                 135                 140                 


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
225                 230                 235                 240 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asp Ser 
305                 310     


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Beta chain  CDR1

<400>  38

Met Asp His Glu Asn 
1               5   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Beta chain CDR2

<400>  39

Ser Tyr Asp Val Lys Met 
1               5       


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta3 Beta chain  CDR3

<400>  40

Ala Ser Arg Glu Lys Arg Gly Glu Asp Thr Asp Thr Gln Tyr 
1               5                   10                  


<210>  41
<211>  834
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 alpha chain

<400>  41
atggagaaga atcctttggc agccccatta ctaatcctct ggtttcatct tgactgcgtg       60

agcagcatac tgaacgtgga acaaagtcct cagtcactgc atgttcagga gggagacagc      120

accaatttca cctgcagctt cccttccagc aatttttatg ccttacactg gtacagatgg      180

gaaactgcaa aaagccccga ggccttgttt gtaatgactt taaatgggga tgaaaagaag      240

aaaggacgaa taagtgccac tcttaatacc aaggagggtt acagctattt gtacatcaaa      300

ggatcccagc ctgaagactc agccacatac ctctgtgcct tcgactcgta ctataatgca      360

ggcaacatgc tcacctttgg agggggaaca aggttaatgg tcaaacccca tatccagaac      420

cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta      480

ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc      540

acagacaaaa ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc      600

tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagaa      660

gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt      720

gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgggttccg aatcctcctc      780

ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctaa            834


<210>  42
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 alpha chain

<400>  42

Met Glu Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Phe Asp Ser Tyr Tyr Asn Ala Gly Asn Met Leu Thr Phe Gly Gly 
        115                 120                 125             


Gly Thr Arg Leu Met Val Lys Pro His Ile Gln Asn Pro Asp Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser 
                165                 170                 175     


Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp 
            180                 185                 190         


Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala 
        195                 200                 205             


Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe 
    210                 215                 220                 


Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe 
225                 230                 235                 240 


Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe 
                245                 250                 255     


Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu 
            260                 265                 270         


Arg Leu Trp Ser Ser 
        275         


<210>  43
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 alpha chain CDR1

<400>  43

Ser Ser Asn Phe Tyr Ala 
1               5       


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 alpha chain CDR2

<400>  44

Met Thr Leu Asn Gly Asp Glu 
1               5           


<210>  45
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 alpha chain CDR3

<400>  45

Ala Phe Asp Ser Tyr Tyr Asn Ala Gly Asn Met Leu Thr 
1               5                   10              


<210>  46
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 beta chain

<400>  46
atggatacct ggctcgtatg ctgggcaatt tttagtctct tgaaagcagg actcacagaa       60

cctgaagtca cccagactcc cagccatcag gtcacacaga tgggacagga agtgatcttg      120

cgctgtgtcc ccatctctaa tcacttatac ttctattggt acagacaaat cttggggcag      180

aaagtcgagt ttctggtttc cttttataat aatgaaatct cagagaagtc tgaaatattc      240

gatgatcaat tctcagttga aaggcctgat ggatcaaatt tcactctgaa gatccggtcc      300

acaaagctgg aggactcagc catgtacttc tgtgccagca gcgcagacac cgggacactg      360

aacactgaag ctttctttgg acaaggcacc agactcacag ttgtagagga cctgaacaag      420

gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag cagagatctc ccacacccaa      480

aaggccacac tggtgtgcct ggccacaggc ttcttccccg accacgtgga gctgagctgg      540

tgggtgaatg ggaaggaggt gcacagtggg gtcagcacgg acccgcagcc cctcaaggag      600

cagcccgccc tcaatgactc cagatactgc ctgagcagcc gcctgagggt ctcggccacc      660

ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc agttctacgg gctctcggag      720

aatgacgagt ggacccagga tagggccaaa cccgtcaccc agatcgtcag cgccgaggcc      780

tggggtagag cagactgtgg ctttacctcg gtgtcctacc agcaaggggt cctgtctgcc      840

accatcctct atgagatcct gctagggaag gccaccctgt atgctgtgct ggtcagcgcc      900

cttgtgttga tggccatggt caagagaaag gatttctaa                             939


<210>  47
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 beta chain

<400>  47

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Ala Asp Thr Gly Thr Leu Asn Thr Glu Ala Phe Phe Gly Gln 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro 
    130                 135                 140                 


Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         


Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg 
        195                 200                 205             


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn 
    210                 215                 220                 


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu 
225                 230                 235                 240 


Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val 
                245                 250                 255     


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser 
            260                 265                 270         


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
        275                 280                 285             


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met 
    290                 295                 300                 


Ala Met Val Lys Arg Lys Asp Phe 
305                 310         


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 beta chain CDR1

<400>  48

Ser Asn His Leu Tyr 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 beta chain CDR2

<400>  49

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  50
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR Clone Vbeta22 beta chain CDR3

<400>  50

Ala Ser Ser Ala Asp Thr Gly Thr Leu Asn Thr Glu Ala Phe 
1               5                   10                  


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  51

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly 
        


