                               SEQUENCE LISTING

<110> DANA-FARBER CANCER INSTITUTE, INC.
 
<120> TREATING MERKEL CELL CARCINOMA

<130> 00530-0340WO1

<140> PCT/US2018/055611
<141> 2018-10-12

<150> 62/571,668
<151> 2017-10-12

<160> 33    

<170> PatentIn version 3.5

<210> 1
<211> 43
<212> PRT
<213> Merkel cell polyomavirus

<400> 1
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Thr Leu Lys Asp Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 2
<211> 439
<212> PRT
<213> Homo sapiens

<400> 2
Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210> 3
<211> 464
<212> PRT
<213> Homo sapiens

<400> 3
Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210> 4
<211> 364
<212> PRT
<213> Homo sapiens

<400> 4
Met Asp Tyr Asp Ser Tyr Gln His Tyr Phe Tyr Asp Tyr Asp Cys Gly 
1               5                   10                  15      


Glu Asp Phe Tyr Arg Ser Thr Ala Pro Ser Glu Asp Ile Trp Lys Lys 
            20                  25                  30          


Phe Glu Leu Val Pro Ser Pro Pro Thr Ser Pro Pro Trp Gly Leu Gly 
        35                  40                  45              


Pro Gly Ala Gly Asp Pro Ala Pro Gly Ile Gly Pro Pro Glu Pro Trp 
    50                  55                  60                  


Pro Gly Gly Cys Thr Gly Asp Glu Ala Glu Ser Arg Gly His Ser Lys 
65                  70                  75                  80  


Gly Trp Gly Arg Asn Tyr Ala Ser Ile Ile Arg Arg Asp Cys Met Trp 
                85                  90                  95      


Ser Gly Phe Ser Ala Arg Glu Arg Leu Glu Arg Ala Val Ser Asp Arg 
            100                 105                 110         


Leu Ala Pro Gly Ala Pro Arg Gly Asn Pro Pro Lys Ala Ser Ala Ala 
        115                 120                 125             


Pro Asp Cys Thr Pro Ser Leu Glu Ala Gly Asn Pro Ala Pro Ala Ala 
    130                 135                 140                 


Pro Cys Pro Leu Gly Glu Pro Lys Thr Gln Ala Cys Ser Gly Ser Glu 
145                 150                 155                 160 


Ser Pro Ser Asp Ser Glu Asn Glu Glu Ile Asp Val Val Thr Val Glu 
                165                 170                 175     


Lys Arg Gln Ser Leu Gly Ile Arg Lys Pro Val Thr Ile Thr Val Arg 
            180                 185                 190         


Ala Asp Pro Leu Asp Pro Cys Met Lys His Phe His Ile Ser Ile His 
        195                 200                 205             


Gln Gln Gln His Asn Tyr Ala Ala Arg Phe Pro Pro Glu Ser Cys Ser 
    210                 215                 220                 


Gln Glu Glu Ala Ser Glu Arg Gly Pro Gln Glu Glu Val Leu Glu Arg 
225                 230                 235                 240 


Asp Ala Ala Gly Glu Lys Glu Asp Glu Glu Asp Glu Glu Ile Val Ser 
                245                 250                 255     


Pro Pro Pro Val Glu Ser Glu Ala Ala Gln Ser Cys His Pro Lys Pro 
            260                 265                 270         


Val Ser Ser Asp Thr Glu Asp Val Thr Lys Arg Lys Asn His Asn Phe 
        275                 280                 285             


Leu Glu Arg Lys Arg Arg Asn Asp Leu Arg Ser Arg Phe Leu Ala Leu 
    290                 295                 300                 


Arg Asp Gln Val Pro Thr Leu Ala Ser Cys Ser Lys Ala Pro Lys Val 
305                 310                 315                 320 


Val Ile Leu Ser Lys Ala Leu Glu Tyr Leu Gln Ala Leu Val Gly Ala 
                325                 330                 335     


Glu Lys Arg Met Ala Thr Glu Lys Arg Gln Leu Arg Cys Arg Gln Gln 
            340                 345                 350         


Gln Leu Gln Lys Arg Ile Ala Tyr Leu Thr Gly Tyr 
        355                 360                 


<210> 5
<211> 394
<212> PRT
<213> Homo sapiens

<400> 5
Met Cys Val Cys Ala Gly Cys Arg Ala Ala Pro Ser Arg Arg Gly Ala 
1               5                   10                  15      


Gly Pro Leu Gln Val Ala Gly Gly Trp Ser Glu Gly Ala Asp Met Asp 
            20                  25                  30          


Tyr Asp Ser Tyr Gln His Tyr Phe Tyr Asp Tyr Asp Cys Gly Glu Asp 
        35                  40                  45              


Phe Tyr Arg Ser Thr Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe Glu 
    50                  55                  60                  


Leu Val Pro Ser Pro Pro Thr Ser Pro Pro Trp Gly Leu Gly Pro Gly 
65                  70                  75                  80  


Ala Gly Asp Pro Ala Pro Gly Ile Gly Pro Pro Glu Pro Trp Pro Gly 
                85                  90                  95      


Gly Cys Thr Gly Asp Glu Ala Glu Ser Arg Gly His Ser Lys Gly Trp 
            100                 105                 110         


Gly Arg Asn Tyr Ala Ser Ile Ile Arg Arg Asp Cys Met Trp Ser Gly 
        115                 120                 125             


Phe Ser Ala Arg Glu Arg Leu Glu Arg Ala Val Ser Asp Arg Leu Ala 
    130                 135                 140                 


Pro Gly Ala Pro Arg Gly Asn Pro Pro Lys Ala Ser Ala Ala Pro Asp 
145                 150                 155                 160 


Cys Thr Pro Ser Leu Glu Ala Gly Asn Pro Ala Pro Ala Ala Pro Cys 
                165                 170                 175     


Pro Leu Gly Glu Pro Lys Thr Gln Ala Cys Ser Gly Ser Glu Ser Pro 
            180                 185                 190         


Ser Asp Ser Glu Asn Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg 
        195                 200                 205             


Gln Ser Leu Gly Ile Arg Lys Pro Val Thr Ile Thr Val Arg Ala Asp 
    210                 215                 220                 


Pro Leu Asp Pro Cys Met Lys His Phe His Ile Ser Ile His Gln Gln 
225                 230                 235                 240 


Gln His Asn Tyr Ala Ala Arg Phe Pro Pro Glu Ser Cys Ser Gln Glu 
                245                 250                 255     


Glu Ala Ser Glu Arg Gly Pro Gln Glu Glu Val Leu Glu Arg Asp Ala 
            260                 265                 270         


Ala Gly Glu Lys Glu Asp Glu Glu Asp Glu Glu Ile Val Ser Pro Pro 
        275                 280                 285             


Pro Val Glu Ser Glu Ala Ala Gln Ser Cys His Pro Lys Pro Val Ser 
    290                 295                 300                 


Ser Asp Thr Glu Asp Val Thr Lys Arg Lys Asn His Asn Phe Leu Glu 
305                 310                 315                 320 


Arg Lys Arg Arg Asn Asp Leu Arg Ser Arg Phe Leu Ala Leu Arg Asp 
                325                 330                 335     


Gln Val Pro Thr Leu Ala Ser Cys Ser Lys Ala Pro Lys Val Val Ile 
            340                 345                 350         


Leu Ser Lys Ala Leu Glu Tyr Leu Gln Ala Leu Val Gly Ala Glu Lys 
        355                 360                 365             


Arg Met Ala Thr Glu Lys Arg Gln Leu Arg Cys Arg Gln Gln Gln Leu 
    370                 375                 380                 


Gln Lys Arg Ile Ala Tyr Leu Thr Gly Tyr 
385                 390                 


<210> 6
<211> 49
<212> PRT
<213> Merkel cell polyomavirus

<400> 6
Lys Phe Gln Gln Asn Ile His Lys Leu Arg Ser Asp Phe Ser Met Phe 
1               5                   10                  15      


Asp Glu Val Ser Thr Lys Phe Pro Trp Glu Glu Tyr Gly Thr Leu Lys 
            20                  25                  30          


Asp Tyr Met Gln Ser Gly Tyr Asn Ala Arg Phe Cys Arg Gly Ser Lys 
        35                  40                  45              


Cys 
    


<210> 7
<211> 49
<212> PRT
<213> Gorilla gorilla gorilla polyomavirus 1

<400> 7
Lys Phe Gln Arg Asn Ile His Lys Leu Arg Ser Glu Phe Thr Ile Phe 
1               5                   10                  15      


Asp Glu Val Ser Ile Lys Phe Pro Trp Glu Glu Tyr Gly Thr Leu Lys 
            20                  25                  30          


Asp Tyr Met Gln Ser Gly Tyr Arg Ala Ile Phe Cys Lys Gly Pro Gly 
        35                  40                  45              


Cys 
    


<210> 8
<211> 45
<212> PRT
<213> Human polyomavirus 14

<400> 8
Lys Phe Thr Thr Ser Leu Thr Glu Ala Arg Ala Ser Thr Tyr Gln Ala 
1               5                   10                  15      


Ser Thr Leu Phe Trp Glu Ile Asp Asn Pro Leu Lys Asn Leu Leu Gly 
            20                  25                  30          


Pro Val Ile Lys Arg Pro Phe Leu Lys Ser Pro His Cys 
        35                  40                  45  


<210> 9
<211> 46
<212> PRT
<213> Human polyomavirus 13

<400> 9
Lys Phe Gln Glu Gly Leu Ile Glu Val Arg Asp Ser Glu Val Cys Gln 
1               5                   10                  15      


Val Ser Phe Ser Asp Cys Tyr Asp Ser Ser Leu Leu Lys Cys Cys Ser 
            20                  25                  30          


Pro Lys Val Phe His Glu Leu Phe Leu Arg Ser Pro Gln Cys 
        35                  40                  45      


<210> 10
<211> 51
<212> PRT
<213> Human polyomavirus 9

<400> 10
Lys Leu Gln Val Thr Leu Leu Glu Ile Arg Ser Asn Cys Gly Ser Ser 
1               5                   10                  15      


Ser Ser Gln Val Ala Trp Tyr Phe Trp Asp Glu Asn Phe Arg Thr Leu 
            20                  25                  30          


Gly Ala Phe Leu Gly Glu Lys Phe Asn Gln Arg Ile Ile Gly Gly Tyr 
        35                  40                  45              


Pro Asp Cys 
    50      


<210> 11
<211> 53
<212> PRT
<213> Human polyomavirus 8

<400> 11
Lys Leu Gln Glu Gly Ile Tyr Asn Ala Arg Gln Glu Phe Pro Thr Ser 
1               5                   10                  15      


Phe Ser Ser Gln Val Gly Ser Trp Tyr Trp Glu Ala Asn Leu Ile Ser 
            20                  25                  30          


Leu Lys Glu Tyr Phe Gly Lys Lys Lys Tyr Asp Glu Asn Val Ile Lys 
        35                  40                  45              


His Trp Pro Gln Cys 
    50              


<210> 12
<211> 61
<212> PRT
<213> Human polyomavirus 4

<400> 12
Lys Leu Gln Glu Cys Val Ser Thr Val His Gln Leu Asn Glu Glu Glu 
1               5                   10                  15      


Asp Glu Val Trp Ser Ser Ser Gln Val Glu Cys Thr Glu Leu Cys Cys 
            20                  25                  30          


Asn Phe Pro Pro Arg Lys Tyr Arg Leu Val Gly Glu Val Tyr Gly Asp 
        35                  40                  45              


Val Phe Glu Glu Tyr Ile Leu Lys Asp Trp Asp Ile Cys 
    50                  55                  60      


<210> 13
<211> 57
<212> PRT
<213> Human polyomavirus 3

<400> 13
Lys Leu Gln Asp Ser Val Ser Ser Val His Asp Leu Asn Glu Glu Glu 
1               5                   10                  15      


Asp Asn Ile Trp Gln Ser Ser Gln Val Tyr Cys Lys Asp Leu Cys Cys 
            20                  25                  30          


Asn Lys Phe Arg Leu Val Gly Ala Ile Tyr Gly Asp Tyr Tyr Glu Ala 
        35                  40                  45              


Tyr Ile Met Lys Gln Trp Asp Val Cys 
    50                  55          


<210> 14
<211> 51
<212> PRT
<213> Human polyomavirus 6

<400> 14
Lys Leu Asn Ala Thr Leu Arg Asp Gln Met Ser Ser Ser Pro Thr Trp 
1               5                   10                  15      


Cys Phe Ser Ser Glu Val Ser Asp Asp Trp Gly Ile Pro Leu Thr Val 
            20                  25                  30          


Gly Glu Phe Leu Gly Pro Glu Phe His Lys Arg Lys Val Trp Asp Phe 
        35                  40                  45              


Arg Leu Cys 
    50      


<210> 15
<211> 51
<212> PRT
<213> Human polyomavirus 7

<400> 15
Lys Leu Glu Ala Thr Leu Arg Asp Gln Arg Ser Gly Ser Pro Met Trp 
1               5                   10                  15      


His Tyr Ser Ser Asp Glu Val Ser Phe Trp Asp Ile Glu Leu Thr Val 
            20                  25                  30          


Gly Glu Phe Leu Gly Pro Glu Phe Asn Arg Lys Lys Val Trp Asn Tyr 
        35                  40                  45              


Asn Leu Cys 
    50      


<210> 16
<211> 50
<212> PRT
<213> Human polyomavirus 10

<400> 16
Lys Met Tyr Thr Thr Ile Glu Lys Leu Arg Arg Glu Gly Glu Val Tyr 
1               5                   10                  15      


Phe Pro Ala Lys Val Gly Tyr Phe Ile Asp Asp Val Val Thr Leu Gly 
            20                  25                  30          


Asp Val Leu Gly Pro Ser Phe Glu Glu Lys Ile Ile Tyr Ile Trp Pro 
        35                  40                  45              


Leu Cys 
    50  


<210> 17
<211> 52
<212> PRT
<213> Human polyomavirus 11

<400> 17
Arg Met Gln Asn Thr Leu Gln Asn Leu Arg Ser Ser Asn Glu Asn Glu 
1               5                   10                  15      


Asn Met Tyr Pro Pro Val Arg Met Leu Leu Leu Thr Asp Thr Phe Thr 
            20                  25                  30          


Leu Gly Glu Leu Leu Gly Pro Gln Phe Glu Ser Lys Val Ile Phe Ile 
        35                  40                  45              


Trp Pro Thr Cys 
    50          


<210> 18
<211> 41
<212> PRT
<213> Human polyomavirus 1

<400> 18
Lys Met Glu Gln Asp Val Lys Val Ala His Gln Pro Asp Phe Gly Thr 
1               5                   10                  15      


Trp Ser Ser Ser Glu Val Cys Ala Asp Phe Pro Leu Cys Pro Asp Thr 
            20                  25                  30          


Leu Tyr Cys Lys Glu Trp Pro Ile Cys 
        35                  40      


<210> 19
<211> 41
<212> PRT
<213> Human polyomavirus 2

<400> 19
Lys Met Glu Gln Gly Val Lys Val Ala His Gln Pro Asp Phe Gly Thr 
1               5                   10                  15      


Trp Asn Ser Ser Glu Val Gly Cys Asp Phe Pro Pro Asn Ser Asp Thr 
            20                  25                  30          


Leu Tyr Cys Lys Glu Trp Pro Asn Cys 
        35                  40      


<210> 20
<211> 40
<212> PRT
<213> Human polyomavirus 12

<400> 20
Lys Phe Lys Asp Gly Ile Tyr Asn Leu Arg Glu Val Lys Pro Ser Leu 
1               5                   10                  15      


His Pro Val Val Thr Cys Thr Val Leu Gly Ala Arg Asn Ile Phe Asn 
            20                  25                  30          


Leu Ile Thr Asn Ser Ser Gln Cys 
        35                  40  


<210> 21
<211> 876
<212> PRT
<213> Homo sapiens

<400> 21
Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Gln Ala Gly 
                165                 170                 175     


Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp Gly Gln Ala Ser 
            180                 185                 190         


Gly Val Glu Gly Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met 
        195                 200                 205             


Thr Ser Gln Glu Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln 
    210                 215                 220                 


Gln Thr Gln Lys Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu 
225                 230                 235                 240 


Trp Leu Asp Asn Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln 
                245                 250                 255     


Gln Leu Glu Ala Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val 
            260                 265                 270         


His Ser Tyr Leu Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys 
        275                 280                 285             


Arg Ile Lys Pro Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile 
    290                 295                 300                 


Gly Ser Gly Val Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe 
305                 310                 315                 320 


Gly Met Asp Val Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg 
                325                 330                 335     


Val Ala Thr Phe Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met 
            340                 345                 350         


Val Val Thr Gly Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln 
        355                 360                 365             


Val Asn Met Glu Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu 
    370                 375                 380                 


Ala Asn Gly Gln Ala Asp Thr Val Lys Val Pro Lys Glu Lys Asp Glu 
385                 390                 395                 400 


Met Val Glu Gln Glu Phe Asn Arg Leu Leu Glu Ala Thr Ser Tyr Leu 
                405                 410                 415     


Ser His Gln Leu Asp Phe Asn Val Leu Asn Asn Lys Pro Val Ser Leu 
            420                 425                 430         


Gly Gln Ala Leu Glu Val Val Ile Gln Leu Gln Glu Lys His Val Lys 
        435                 440                 445             


Asp Glu Gln Ile Glu His Trp Lys Lys Ile Val Lys Thr Gln Glu Glu 
    450                 455                 460                 


Leu Lys Glu Leu Leu Asn Lys Met Val Asn Leu Lys Glu Lys Ile Lys 
465                 470                 475                 480 


Glu Leu His Gln Gln Tyr Lys Glu Ala Ser Glu Val Lys Pro Pro Arg 
                485                 490                 495     


Asp Ile Thr Ala Glu Phe Leu Val Lys Ser Lys His Arg Asp Leu Thr 
            500                 505                 510         


Ala Leu Cys Lys Glu Tyr Asp Glu Leu Ala Glu Thr Gln Gly Lys Leu 
        515                 520                 525             


Glu Glu Lys Leu Gln Glu Leu Glu Ala Asn Pro Pro Ser Asp Val Tyr 
    530                 535                 540                 


Leu Ser Ser Arg Asp Arg Gln Ile Leu Asp Trp His Phe Ala Asn Leu 
545                 550                 555                 560 


Glu Phe Ala Asn Ala Thr Pro Leu Ser Thr Leu Ser Leu Lys His Trp 
                565                 570                 575     


Asp Gln Asp Asp Asp Phe Glu Phe Thr Gly Ser His Leu Thr Val Arg 
            580                 585                 590         


Asn Gly Tyr Ser Cys Val Pro Val Ala Leu Ala Glu Gly Leu Asp Ile 
        595                 600                 605             


Lys Leu Asn Thr Ala Val Arg Gln Val Arg Tyr Thr Ala Ser Gly Cys 
    610                 615                 620                 


Glu Val Ile Ala Val Asn Thr Arg Ser Thr Ser Gln Thr Phe Ile Tyr 
625                 630                 635                 640 


Lys Cys Asp Ala Val Leu Cys Thr Leu Pro Leu Gly Val Leu Lys Gln 
                645                 650                 655     


Gln Pro Pro Ala Val Gln Phe Val Pro Pro Leu Pro Glu Trp Lys Thr 
            660                 665                 670         


Ser Ala Val Gln Arg Met Gly Phe Gly Asn Leu Asn Lys Val Val Leu 
        675                 680                 685             


Cys Phe Asp Arg Val Phe Trp Asp Pro Ser Val Asn Leu Phe Gly His 
    690                 695                 700                 


Val Gly Ser Thr Thr Ala Ser Arg Gly Glu Leu Phe Leu Phe Trp Asn 
705                 710                 715                 720 


Leu Tyr Lys Ala Pro Ile Leu Leu Ala Leu Val Ala Gly Glu Ala Ala 
                725                 730                 735     


Gly Ile Met Glu Asn Ile Ser Asp Asp Val Ile Val Gly Arg Cys Leu 
            740                 745                 750         


Ala Ile Leu Lys Gly Ile Phe Gly Ser Ser Ala Val Pro Gln Pro Lys 
        755                 760                 765             


Glu Thr Val Val Ser Arg Trp Arg Ala Asp Pro Trp Ala Arg Gly Ser 
    770                 775                 780                 


Tyr Ser Tyr Val Ala Ala Gly Ser Ser Gly Asn Asp Tyr Asp Leu Met 
785                 790                 795                 800 


Ala Gln Pro Ile Thr Pro Gly Pro Ser Ile Pro Gly Ala Pro Gln Pro 
                805                 810                 815     


Ile Pro Arg Leu Phe Phe Ala Gly Glu His Thr Ile Arg Asn Tyr Pro 
            820                 825                 830         


Ala Thr Val His Gly Ala Leu Leu Ser Gly Leu Arg Glu Ala Gly Arg 
        835                 840                 845             


Ile Ala Asp Gln Phe Leu Gly Ala Met Tyr Thr Leu Pro Arg Gln Ala 
    850                 855                 860                 


Thr Pro Gly Val Pro Ala Gln Gln Ser Pro Ser Met 
865                 870                 875     


<210> 22
<211> 2631
<212> DNA
<213> Homo sapiens

<400> 22
atgttatctg ggaagaaggc ggcagccgcg gcggcggcgg ctgcagcggc agcaaccggg       60

acggaggctg gccctgggac agcaggcggc tccgagaacg ggtctgaggt ggccgcgcag      120

cccgcgggcc tgtcgggccc agccgaggtc gggccggggg cggtggggga gcgcacaccc      180

cgcaagaaag agcctccgcg ggcctcgccc cccgggggcc tggcggaacc gccggggtcc      240

gcagggcctc aggccggccc tactgtcgtg cctgggtctg cgacccccat ggaaactgga      300

atagcagaga ctccggaggg gcgtcggacc agccggcgca agcgggcgaa ggtagagtac      360

agagagatgg atgaaagctt ggccaacctc tcagaagatg agtattattc agaagaagag      420

agaaatgcca aagcagagaa ggaaaagaag cttcccccac caccccctca agccccacct      480

gaggaagaaa atgaaagtga gcctgaagaa ccatcggggc aagcaggagg acttcaagac      540

gacagttctg gagggtatgg agacggccaa gcatcaggtg tggagggcgc agctttccag      600

agccgacttc ctcatgaccg gatgacttct caagaagcag cctgttttcc agatattatc      660

agtggaccac aacagaccca gaaggttttt cttttcatta gaaaccgcac actgcagttg      720

tggttggata atccaaagat tcagctgaca tttgaggcta ctctccaaca attagaagca      780

ccttataaca gtgatactgt gcttgtccac cgagttcaca gttatttaga gcgtcatggt      840

cttatcaact tcggcatcta taagaggata aaacccctac caactaaaaa gacaggaaag      900

gtaattatta taggctctgg ggtctcaggc ttggcagcag ctcgacagtt acaaagtttt      960

ggaatggatg tcacactttt ggaagccagg gatcgtgtgg gtggacgagt tgccacattt     1020

cgcaaaggaa actatgtagc tgatcttgga gccatggtgg taacaggtct tggagggaat     1080

cctatggctg tggtcagcaa acaagtaaat atggaactgg ccaagatcaa gcaaaaatgc     1140

ccactttatg aagccaacgg acaagctgac actgtcaagg ttcctaaaga gaaagatgaa     1200

atggtagagc aagagtttaa ccggttgcta gaagctacat cttaccttag tcatcaacta     1260

gacttcaatg tcctcaataa taagcctgtg tcccttggcc aggcattgga agttgtcatt     1320

cagttacaag agaagcatgt caaagatgag cagattgaac attggaagaa gatagtgaaa     1380

actcaggaag aattgaaaga acttcttaat aagatggtaa atttgaaaga gaaaattaaa     1440

gaactccatc agcaatacaa agaagcatct gaagtaaagc cacccagaga tattactgcc     1500

gagttcttag tgaaaagcaa acacagggat ctgaccgccc tatgcaagga atatgatgaa     1560

ttagctgaaa cacaaggaaa gctagaagaa aaacttcagg agttggaagc gaatccccca     1620

agtgatgtat atctctcatc aagagacaga caaatacttg attggcattt tgcaaatctt     1680

gaatttgcta atgccacacc tctctcaact ctctccctta agcactggga tcaggatgat     1740

gactttgagt tcactggcag ccacctgaca gtaaggaatg gctactcgtg tgtgcctgtg     1800

gctttagcag aaggcctaga cattaaactg aatacagcag tgcgacaggt tcgctacacg     1860

gcttcaggat gtgaagtgat agctgtgaat acccgctcca cgagtcaaac ctttatttat     1920

aaatgcgacg cagttctctg tacccttccc ctgggtgtgc tgaagcagca gccaccagcc     1980

gttcagtttg tgccacctct ccctgagtgg aaaacatctg cagtccaaag gatgggattt     2040

ggcaacctta acaaggtggt gttgtgtttt gatcgggtgt tctgggatcc aagtgtcaat     2100

ttgttcgggc atgttggcag tacgactgcc agcaggggtg agctcttcct cttctggaac     2160

ctctataaag ctccaatact gttggcacta gtggcaggag aagctgctgg tatcatggaa     2220

aacataagtg acgatgtgat tgttggccga tgcctggcca ttctcaaagg gatttttggt     2280

agcagtgcag tacctcagcc caaagaaact gtggtgtctc gttggcgtgc tgatccctgg     2340

gctcggggct cttattccta tgttgctgca ggatcatctg gaaatgacta tgatttaatg     2400

gctcagccaa tcactcctgg cccctcgatt ccaggtgccc cacagccgat tccacgactc     2460

ttctttgcgg gagaacatac gatccgtaac tacccagcca cagtgcatgg tgctctgctg     2520

agtgggctgc gagaagcggg aagaattgca gaccagtttt tgggggccat gtatacgctg     2580

cctcgccagg ccacaccagg tgttcctgca cagcagtccc caagcatgtg a              2631


<210> 23
<211> 21
<212> PRT
<213> Homo sapiens

<400> 23
Gly Gln Ala Gly Gly Leu Gln Asp Asp Ser Ser Gly Gly Tyr Gly Asp 
1               5                   10                  15      


Gly Gln Ala Ser Gly 
            20      


<210> 24
<211> 5
<212> PRT
<213> Homo sapiens

<400> 24
Ala Asp Thr Val Lys 
1               5   


<210> 25
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Arg Ser Asp Phe Ser Met Phe Ala Ala Ala Ala Ala Ala Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Thr Leu Lys Asp Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 26
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Ala Ala Ala 
1               5                   10                  15      


Ala Ala Ala Gly Thr Leu Lys Asp Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 27
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Ala Ala Ala Ala Ala Ala Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 28
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Thr Leu Lys Ala Ala Ala Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 29
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Thr Leu Lys Asp Tyr Met Ala Ala Ala Ala Ala Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 30
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Thr Leu Lys Asp Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Ala Ala Ala Ala Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 31
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Ser Ser Tyr Gly Thr Leu Lys Asp Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 32
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Glu Glu Tyr Gly Thr Leu Ser Ser Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


<210> 33
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Arg Ser Asp Phe Ser Met Phe Asp Glu Val Ser Thr Lys Phe Pro Trp 
1               5                   10                  15      


Ser Ser Tyr Gly Thr Leu Ser Ser Tyr Met Gln Ser Gly Tyr Asn Ala 
            20                  25                  30          


Arg Phe Cys Arg Gly Pro Gly Cys Met Leu Lys 
        35                  40              


