                         SEQUENCE LISTING

<110>  Bioverativ USA Inc
       PANICKER, SANDIP
       MOORE, STEPHEN
       NIKITIN, PAVEL
       BYUN, TONY
       PARRY, Graham
 
<120>  METHODS OF INDUCING COMPLEMENT ACTIVITY

<130>  4159.517PC02/C-K/DHH

<150>  US 62/637,135
<151>  2018-03-01

<150>  US 62/570,953
<151>  2017-10-11

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  1

Gly Tyr Ser Phe Thr Asp Tyr Leu 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  2

Ile Asn Pro Tyr Asn Gly Asp Ala 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  3

Ala Arg Leu Glu Asn Asp Tyr Gly Phe Thr Tyr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  4

Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  5
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  5

Arg Met Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  6

Ala Gln Met Leu Glu Arg Pro Trp Thr 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Factor B VH

<400>  7

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Leu Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Asp Ala Phe Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Glu Asn Asp Tyr Gly Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  8
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Factor B VL

<400>  8

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      


Leu Glu Arg Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-Factor B Heavy Chain

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Leu Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Asp Ala Phe Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Glu Asn Asp Tyr Gly Phe Thr Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 


<210>  10
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antifactor B Light Chain

<400>  10

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Ser Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Met 
                85                  90                  95      


Leu Glu Arg Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly 
    210                 215     


<210>  11
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Factor B  VH

<400>  11
gaagtgcaac tccaacagag cggaccagaa cttgtgaagc ccggagcctc agtgaagatg       60

tcctgtaagg cttccggata ttccttcact gattacctga tgaactgggt caagcagagc      120

catggaaagt ccctggagtg gattgggcgc atcaatccgt acaacggcga tgcgttctac      180

aaccagcggt ttaaggggaa ggccaccctg accgtggaca agtcatcgtc caccgcccac      240

atggagttga gatccctgac ctcggaggac agcgccctct actactgcgc aaggctggaa      300

aacgattacg gcttcaccta ctggggccag ggtactctgg tcactgtgtc cgct            354


<210>  12
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-factor B Heavy chain

<400>  12
gaagtgcaac tccaacagag cggaccagaa cttgtgaagc ccggagcctc agtgaagatg       60

tcctgtaagg cttccggata ttccttcact gattacctga tgaactgggt caagcagagc      120

catggaaagt ccctggagtg gattgggcgc atcaatccgt acaacggcga tgcgttctac      180

aaccagcggt ttaaggggaa ggccaccctg accgtggaca agtcatcgtc caccgcccac      240

atggagttga gatccctgac ctcggaggac agcgccctct actactgcgc aaggctggaa      300

aacgattacg gcttcaccta ctggggccag ggtactctgg tcactgtgtc cgcttccacc      360

aagggcccat ccgtcttccc cctggcgccc tgctccagga gcacctccga gagcacagcc      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacgaagac ctacacctgc      600

aatgtagatc acaagcccag caacaccaag gtggacaaga gagttgagtc caaatatggt      660

cccccatgcc caccatgccc agcacctgag ttcgaggggg gaccatcagt cttcctgttc      720

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      780

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      840

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      900

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      960

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc     1020

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc     1080

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc     1140

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc     1200

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc     1260

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg     1320

tctctgggta aatga                                                      1335


<210>  13
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  13
gatatcgtga tgacccaggc tgccttctcc aaccctgtga ctctcggaac ctccgcctca       60

atctcctgct cgtcatccaa gtccctgctt cactcgaacg ggattaccta cctgtattgg      120

tacttgcaaa gaccgggcca gagcccccag ctgctgatct accgcatgtc gaacctggcc      180

agcggagtgc cagaccggtt ctccggttct ggttccggga ctgacttcac tctgcggatt      240

agcagggtgg aagcagagga cgtcggagtg tactactgtg cgcagatgct cgagcgcccg      300

tggacctttg gcggaggcac caagctggaa atcaagact                             339


<210>  14
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<400>  14
gatatcgtga tgacccaggc tgccttctcc aaccctgtga ctctcggaac ctccgcctca       60

atctcctgct cgtcatccaa gtccctgctt cactcgaacg ggattaccta cctgtattgg      120

tacttgcaaa gaccgggcca gagcccccag ctgctgatct accgcatgtc gaacctggcc      180

agcggagtgc cagaccggtt ctccggttct ggttccggga ctgacttcac tctgcggatt      240

agcagggtgg aagcagagga cgtcggagtg tactactgtg cgcagatgct cgagcgcccg      300

tggacctttg gcggaggcac caagctggaa atcaagactg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag         657


<210>  15
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human Factor Bb

<400>  15

Met Gly Ser Asn Leu Ser Pro Gln Leu Cys Leu Met Pro Phe Ile Leu 
1               5                   10                  15      


Gly Leu Leu Ser Gly Gly Val Thr Thr Thr Pro Trp Ser Leu Ala Arg 
            20                  25                  30          


Pro Gln Gly Ser Cys Ser Leu Glu Gly Val Glu Ile Lys Gly Gly Ser 
        35                  40                  45              


Phe Arg Leu Leu Gln Glu Gly Gln Ala Leu Glu Tyr Val Cys Pro Ser 
    50                  55                  60                  


Gly Phe Tyr Pro Tyr Pro Val Gln Thr Arg Thr Cys Arg Ser Thr Gly 
65                  70                  75                  80  


Ser Trp Ser Thr Leu Lys Thr Gln Asp Gln Lys Thr Val Arg Lys Ala 
                85                  90                  95      


Glu Cys Arg Ala Ile His Cys Pro Arg Pro His Asp Phe Glu Asn Gly 
            100                 105                 110         


Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr Asn Val Ser Asp Glu Ile Ser 
        115                 120                 125             


Phe His Cys Tyr Asp Gly Tyr Thr Leu Arg Gly Ser Ala Asn Arg Thr 
    130                 135                 140                 


Cys Gln Val Asn Gly Arg Trp Ser Gly Gln Thr Ala Ile Cys Asp Asn 
145                 150                 155                 160 


Gly Ala Gly Tyr Cys Ser Asn Pro Gly Ile Pro Ile Gly Thr Arg Lys 
                165                 170                 175     


Val Gly Ser Gln Tyr Arg Leu Glu Asp Ser Val Thr Tyr His Cys Ser 
            180                 185                 190         


Arg Gly Leu Thr Leu Arg Gly Ser Gln Arg Arg Thr Cys Gln Glu Gly 
        195                 200                 205             


Gly Ser Trp Ser Gly Thr Glu Pro Ser Cys Gln Asp Ser Phe Met Tyr 
    210                 215                 220                 


Asp Thr Pro Gln Glu Val Ala Glu Ala Phe Leu Ser Ser Leu Thr Glu 
225                 230                 235                 240 


Thr Ile Glu Gly Val Asp Ala Glu Asp Gly His Gly Pro Gly Glu Gln 
                245                 250                 255     


Gln Lys Arg Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr 
            260                 265                 270         


Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly 
        275                 280                 285             


Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
    290                 295                 300                 


Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile 
305                 310                 315                 320 


Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr 
                325                 330                 335     


Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly 
            340                 345                 350         


Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp 
        355                 360                 365             


Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile 
    370                 375                 380                 


Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr 
385                 390                 395                 400 


Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys Asp Arg Lys 
                405                 410                 415     


Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro 
            420                 425                 430         


Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn 
        435                 440                 445             


Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val 
    450                 455                 460                 


Phe Tyr Gln Met Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met 
465                 470                 475                 480 


Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln 
                485                 490                 495     


Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met 
            500                 505                 510         


Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe 
        515                 520                 525             


Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu 
    530                 535                 540                 


Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn 
545                 550                 555                 560 


Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp 
                565                 570                 575     


Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile 
            580                 585                 590         


Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg 
        595                 600                 605             


Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro 
    610                 615                 620                 


Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu 
625                 630                 635                 640 


Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys 
                645                 650                 655     


Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile 
            660                 665                 670         


Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro 
        675                 680                 685             


Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile 
    690                 695                 700                 


Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly 
705                 710                 715                 720 


Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala 
                725                 730                 735     


His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu 
            740                 745                 750         


Lys Glu Lys Leu Gln Asp Glu Asp Leu Gly Phe Leu 
        755                 760                 


