                         SEQUENCE LISTING

<110>  University of Vriginia Patent Foundation
       Ambati, Jayakrishna
       Kerur, Nagaraj
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED MACULAR 
       DEGENERATION AND GEOGRAPHIC ATROPHY

<130>  02401-02

<150>  US 62/570,207
<151>  2017-10-10

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  1
ccggctttga taactgcgtg acatactcga gtatgtcacg cagttatcaa agttttttg        59


<210>  2
<211>  48
<212>  DNA
<213>  Homo sapiens

<400>  2
aagaagaaac atggcggcta tccttctctc acatcgaaaa ggaaattt                    48


<210>  3
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Pro Trp His Gly Lys Ala Met Gln Arg Ala Ser Glu Ala Gly 
1               5                   10                  15      


Ala Thr Ala Pro Lys Ala Ser Ala Arg Asn Ala Arg Gly Ala Pro Met 
            20                  25                  30          


Asp Pro Thr Glu Ser Pro Ala Ala Pro Glu Ala Ala Leu Pro Lys Ala 
        35                  40                  45              


Gly Lys Phe Gly Pro Ala Arg Lys Ser Gly Ser Arg Gln Lys Lys Ser 
    50                  55                  60                  


Ala Pro Asp Thr Gln Glu Arg Pro Pro Val Arg Ala Thr Gly Ala Arg 
65                  70                  75                  80  


Ala Lys Lys Ala Pro Gln Arg Ala Gln Asp Thr Gln Pro Ser Asp Ala 
                85                  90                  95      


Thr Ser Ala Pro Gly Ala Glu Gly Leu Glu Pro Pro Ala Ala Arg Glu 
            100                 105                 110         


Pro Ala Leu Ser Arg Ala Gly Ser Cys Arg Gln Arg Gly Ala Arg Cys 
        115                 120                 125             


Ser Thr Lys Pro Arg Pro Pro Pro Gly Pro Trp Asp Val Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Val Ser Ala Pro Ile Leu Val Arg Arg Asp Ala Ala Pro 
145                 150                 155                 160 


Gly Ala Ser Lys Leu Arg Ala Val Leu Glu Lys Leu Lys Leu Ser Arg 
                165                 170                 175     


Asp Asp Ile Ser Thr Ala Ala Gly Met Val Lys Gly Val Val Asp His 
            180                 185                 190         


Leu Leu Leu Arg Leu Lys Cys Asp Ser Ala Phe Arg Gly Val Gly Leu 
        195                 200                 205             


Leu Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala Pro Asn 
    210                 215                 220                 


Glu Phe Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Gln Leu Glu 
225                 230                 235                 240 


Glu Tyr Ser Asn Thr Arg Ala Tyr Tyr Phe Val Lys Phe Lys Arg Asn 
                245                 250                 255     


Pro Lys Glu Asn Pro Leu Ser Gln Phe Leu Glu Gly Glu Ile Leu Ser 
            260                 265                 270         


Ala Ser Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu Glu Ile 
        275                 280                 285             


Asn Asp Ile Lys Asp Thr Asp Val Ile Met Lys Arg Lys Arg Gly Gly 
    290                 295                 300                 


Ser Pro Ala Val Thr Leu Leu Ile Ser Glu Lys Ile Ser Val Asp Ile 
305                 310                 315                 320 


Thr Leu Ala Leu Glu Ser Lys Ser Ser Trp Pro Ala Ser Thr Gln Glu 
                325                 330                 335     


Gly Leu Arg Ile Gln Asn Trp Leu Ser Ala Lys Val Arg Lys Gln Leu 
            340                 345                 350         


Arg Leu Lys Pro Phe Tyr Leu Val Pro Lys His Ala Lys Glu Gly Asn 
        355                 360                 365             


Gly Phe Gln Glu Glu Thr Trp Arg Leu Ser Phe Ser His Ile Glu Lys 
    370                 375                 380                 


Glu Ile Leu Asn Asn His Gly Lys Ser Lys Thr Cys Cys Glu Asn Lys 
385                 390                 395                 400 


Glu Glu Lys Cys Cys Arg Lys Asp Cys Leu Lys Leu Met Lys Tyr Leu 
                405                 410                 415     


Leu Glu Gln Leu Lys Glu Arg Phe Lys Asp Lys Lys His Leu Asp Lys 
            420                 425                 430         


Phe Ser Ser Tyr His Val Lys Thr Ala Phe Phe His Val Cys Thr Gln 
        435                 440                 445             


Asn Pro Gln Asp Ser Gln Trp Asp Arg Lys Asp Leu Gly Leu Cys Phe 
    450                 455                 460                 


Asp Asn Cys Val Thr Tyr Phe Leu Gln Cys Leu Arg Thr Glu Lys Leu 
465                 470                 475                 480 


Glu Asn Tyr Phe Ile Pro Glu Phe Asn Leu Phe Ser Ser Asn Leu Ile 
                485                 490                 495     


Asp Lys Arg Ser Lys Glu Phe Leu Thr Lys Gln Ile Glu Tyr Glu Arg 
            500                 505                 510         


Asn Asn Glu Phe Pro Val Phe Asp Glu Phe 
        515                 520         


<210>  4
<211>  1802
<212>  DNA
<213>  Homo sapiens

<400>  4
agcctggggt tccccttcgg gtcgcagact cttgtgtgcc cgccagtagt gcttggtttc       60

caacagctgc tgctggctct tcctcttgcg gccttttcct gaaacggatt cttctttcgg      120

ggaacagaaa gcgccagcca tgcagccttg gcacggaaag gccatgcaga gagcttccga      180

ggccggagcc actgccccca aggcttccgc acggaatgcc aggggcgccc cgatggatcc      240

caccgagtct ccggctgccc ccgaggccgc cctgcctaag gcgggaaagt tcggccccgc      300

caggaagtcg ggatcccggc agaaaaagag cgccccggac acccaggaga ggccgcccgt      360

ccgcgcaact ggggcccgcg ccaaaaaggc ccctcagcgc gcccaggaca cgcagccgtc      420

tgacgccacc agcgcccctg gggcagaggg gctggagcct cctgcggctc gggagccggc      480

tctttccagg gctggttctt gccgccagag gggcgcgcgc tgctccacga agccaagacc      540

tccgcccggg ccctgggacg tgcccagccc cggcctgccg gtctcggccc ccattctcgt      600

acggagggat gcggcgcctg gggcctcgaa gctccgggcg gttttggaga agttgaagct      660

cagccgcgat gatatctcca cggcggcggg gatggtgaaa ggggttgtgg accacctgct      720

gctcagactg aagtgcgact ccgcgttcag aggcgtcggg ctgctgaaca ccgggagcta      780

ctatgagcac gtgaagattt ctgcacctaa tgaatttgat gtcatgttta aactggaagt      840

ccccagaatt caactagaag aatattccaa cactcgtgca tattactttg tgaaatttaa      900

aagaaatccg aaagaaaatc ctctgagtca gtttttagaa ggtgaaatat tatcagcttc      960

taagatgctg tcaaagttta ggaaaatcat taaggaagaa attaacgaca ttaaagatac     1020

agatgtcatc atgaagagga aaagaggagg gagccctgct gtaacacttc ttattagtga     1080

aaaaatatct gtggatataa ccctggcttt ggaatcaaaa agtagctggc ctgctagcac     1140

ccaagaaggc ctgcgcattc aaaactggct ttcagcaaaa gttaggaagc aactacgact     1200

aaagccattt taccttgtac ccaagcatgc aaaggaagga aatggtttcc aagaagaaac     1260

atggcggcta tccttctctc acatcgaaaa ggaaattttg aacaatcatg gaaaatctaa     1320

aacgtgctgt gaaaacaaag aagagaaatg ttgcaggaaa gattgtttaa aactaatgaa     1380

atacctttta gaacagctga aagaaaggtt taaagacaaa aaacatctgg ataaattctc     1440

ttcttatcat gtgaaaactg ccttctttca cgtatgtacc cagaaccctc aagacagtca     1500

gtgggaccgc aaagacctgg gcctctgctt tgataactgc gtgacatact ttcttcagtg     1560

cctcaggaca gaaaaacttg agaattattt tattcctgaa ttcaatctat tctctagcaa     1620

cttaattgac aaaagaagta aggaatttct gacaaagcaa attgaatatg aaagaaacaa     1680

tgagtttcca gtttttgatg aattttgaga ttgtattttt agaaagatct aagaactaga     1740

gtcaccctaa atcctggaga atacaagaaa aatttgaaaa ggggccagac gctgtggctc     1800

ac                                                                    1802


<210>  5
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Gly Asn His Arg Lys Lys Pro Leu Lys Val Leu Glu Ser 
1               5                   10                  15      


Leu Gly Lys Asp Phe Leu Thr Gly Val Leu Asp Asn Leu Val Glu Gln 
            20                  25                  30          


Asn Val Leu Asn Trp Lys Glu Glu Glu Lys Lys Lys Tyr Tyr Asp Ala 
        35                  40                  45              


Lys Thr Glu Asp Lys Val Arg Val Met Ala Asp Ser Met Gln Glu Lys 
    50                  55                  60                  


Gln Arg Met Ala Gly Gln Met Leu Leu Gln Thr Phe Phe Asn Ile Asp 
65                  70                  75                  80  


Gln Ile Ser Pro Asn Lys Lys Ala His Pro Asn Met Glu Ala Gly Pro 
                85                  90                  95      


Pro Glu Ser Gly Glu Ser Thr Asp Ala Leu Lys Leu Cys Pro His Glu 
            100                 105                 110         


Glu Phe Leu Arg Leu Cys Lys Glu Arg Ala Glu Glu Ile Tyr Pro Ile 
        115                 120                 125             


Lys Glu Arg Asn Asn Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Thr 
    130                 135                 140                 


Glu Phe Asp His Leu Pro Pro Arg Asn Gly Ala Asp Phe Asp Ile Thr 
145                 150                 155                 160 


Gly Met Lys Glu Leu Leu Glu Gly Leu Asp Tyr Ser Val Asp Val Glu 
                165                 170                 175     


Glu Asn Leu Thr Ala Arg Asp Met Glu Ser Ala Leu Arg Ala Phe Ala 
            180                 185                 190         


Thr Arg Pro Glu His Lys Ser Ser Asp Ser Thr Phe Leu Val Leu Met 
        195                 200                 205             


Ser His Gly Ile Leu Glu Gly Ile Cys Gly Thr Val His Asp Glu Lys 
    210                 215                 220                 


Lys Pro Asp Val Leu Leu Tyr Asp Thr Ile Phe Gln Ile Phe Asn Asn 
225                 230                 235                 240 


Arg Asn Cys Leu Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Val Gln 
                245                 250                 255     


Ala Cys Arg Gly Ala Asn Arg Gly Glu Leu Trp Val Arg Asp Ser Pro 
            260                 265                 270         


Ala Ser Leu Glu Val Ala Ser Ser Gln Ser Ser Glu Asn Leu Glu Glu 
        275                 280                 285             


Asp Ala Val Tyr Lys Thr His Val Glu Lys Asp Phe Ile Ala Phe Cys 
    290                 295                 300                 


Ser Ser Thr Pro His Asn Val Ser Trp Arg Asp Ser Thr Met Gly Ser 
305                 310                 315                 320 


Ile Phe Ile Thr Gln Leu Ile Thr Cys Phe Gln Lys Tyr Ser Trp Cys 
                325                 330                 335     


Cys His Leu Glu Glu Val Phe Arg Lys Val Gln Gln Ser Phe Glu Thr 
            340                 345                 350         


Pro Arg Ala Lys Ala Gln Met Pro Thr Ile Glu Arg Leu Ser Met Thr 
        355                 360                 365             


Arg Tyr Phe Tyr Leu Phe Pro Gly Asn 
    370                 375         


<210>  6
<211>  1319
<212>  DNA
<213>  Homo sapiens

<400>  6
atacatagtt tactttcatt tttgactctg aggctctttc caacgctgta aaaaaggaca       60

gaggctgttc cctatggcag aaggcaacca cagaaaaaag ccacttaagg tgttggaatc      120

cctgggcaaa gatttcctca ctggtgtttt ggataacttg gtggaacaaa atgtactgaa      180

ctggaaggaa gaggaaaaaa agaaatatta cgatgctaaa actgaagaca aagttcgggt      240

catggcagac tctatgcaag agaagcaacg tatggcagga caaatgcttc ttcaaacctt      300

ttttaacata gaccaaatat cccccaataa aaaagctcat ccgaatatgg aggctggacc      360

acctgagtca ggagaatcta cagatgccct caagctttgt cctcatgaag aattcctgag      420

actatgtaaa gaaagagctg aagagatcta tccaataaag gagagaaaca accgcacacg      480

cctggctctc atcatatgca atacagagtt tgaccatctg cctccgagga atggagctga      540

ctttgacatc acagggatga aggagctact tgagggtctg gactatagtg tagatgtaga      600

agagaatctg acagccaggg atatggagtc agcgctgagg gcatttgcta ccagaccaga      660

gcacaagtcc tctgacagca cattcttggt actcatgtct catggcatcc tggagggaat      720

ctgcggaact gtgcatgatg agaaaaaacc agatgtgctg ctttatgaca ccatcttcca      780

gatattcaac aaccgcaact gcctcagtct gaaggacaaa cccaaggtca tcattgtcca      840

ggcctgcaga ggtgcaaacc gtggggaact gtgggtcaga gactctccag catccttgga      900

agtggcctct tcacagtcat ctgagaacct agaggaagat gctgtttaca agacccacgt      960

ggagaaggac ttcattgctt tctgctcttc aacgccacac aacgtgtcct ggagagacag     1020

cacaatgggc tctatcttca tcacacaact catcacatgc ttccagaaat attcttggtg     1080

ctgccaccta gaggaagtat ttcggaaggt acagcaatca tttgaaactc caagggccaa     1140

agctcaaatg cccaccatag aacgactgtc catgacaaga tatttctacc tctttcctgg     1200

caattgaaaa tggaagccac aagcagccca gccctcctta atcaacttca aggagcacct     1260

tcattagtac agcttgcata tttaacattt tgtatttcaa taaaagtgaa gacaaacga      1319


<210>  7
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gly Ser Ala Phe Glu Arg Val Val Arg Arg Val Val Gln Glu Leu 
1               5                   10                  15      


Asp His Gly Gly Glu Phe Ile Pro Val Thr Ser Leu Gln Ser Ser Thr 
            20                  25                  30          


Gly Phe Gln Pro Tyr Cys Leu Val Val Arg Lys Pro Ser Ser Ser Trp 
        35                  40                  45              


Phe Trp Lys Pro Arg Tyr Lys Cys Val Asn Leu Ser Ile Lys Asp Ile 
    50                  55                  60                  


Leu Glu Pro Asp Ala Ala Glu Pro Asp Val Gln Arg Gly Arg Ser Phe 
65                  70                  75                  80  


His Phe Tyr Asp Ala Met Asp Gly Gln Ile Gln Gly Ser Val Glu Leu 
                85                  90                  95      


Ala Ala Pro Gly Gln Ala Lys Ile Ala Gly Gly Ala Ala Val Ser Asp 
            100                 105                 110         


Ser Ser Ser Thr Ser Met Asn Val Tyr Ser Leu Ser Val Asp Pro Asn 
        115                 120                 125             


Thr Trp Gln Thr Leu Leu His Glu Arg His Leu Arg Gln Pro Glu His 
    130                 135                 140                 


Lys Val Leu Gln Gln Leu Arg Ser Arg Gly Asp Asn Val Tyr Val Val 
145                 150                 155                 160 


Thr Glu Val Leu Gln Thr Gln Lys Glu Val Glu Val Thr Arg Thr His 
                165                 170                 175     


Lys Arg Glu Gly Ser Gly Arg Phe Ser Leu Pro Gly Ala Thr Cys Leu 
            180                 185                 190         


Gln Gly Glu Gly Gln Gly His Leu Ser Gln Lys Lys Thr Val Thr Ile 
        195                 200                 205             


Pro Ser Gly Ser Thr Leu Ala Phe Arg Val Ala Gln Leu Val Ile Asp 
    210                 215                 220                 


Ser Asp Leu Asp Val Leu Leu Phe Pro Asp Lys Lys Gln Arg Thr Phe 
225                 230                 235                 240 


Gln Pro Pro Ala Thr Gly His Lys Arg Ser Thr Ser Glu Gly Ala Trp 
                245                 250                 255     


Pro Gln Leu Pro Ser Gly Leu Ser Met Met Arg Cys Leu His Asn Phe 
            260                 265                 270         


Leu Thr Asp Gly Val Pro Ala Glu Gly Ala Phe Thr Glu Asp Phe Gln 
        275                 280                 285             


Gly Leu Arg Ala Glu Val Glu Thr Ile Ser Lys Glu Leu Glu Leu Leu 
    290                 295                 300                 


Asp Arg Glu Leu Cys Gln Leu Leu Leu Glu Gly Leu Glu Gly Val Leu 
305                 310                 315                 320 


Arg Asp Gln Leu Ala Leu Arg Ala Leu Glu Glu Ala Leu Glu Gln Gly 
                325                 330                 335     


Gln Ser Leu Gly Pro Val Glu Pro Leu Asp Gly Pro Ala Gly Ala Val 
            340                 345                 350         


Leu Glu Cys Leu Val Leu Ser Ser Gly Met Leu Val Pro Glu Leu Ala 
        355                 360                 365             


Ile Pro Val Val Tyr Leu Leu Gly Ala Leu Thr Met Leu Ser Glu Thr 
    370                 375                 380                 


Gln His Lys Leu Leu Ala Glu Ala Leu Glu Ser Gln Thr Leu Leu Gly 
385                 390                 395                 400 


Pro Leu Glu Leu Val Gly Ser Leu Leu Glu Gln Ser Ala Pro Trp Gln 
                405                 410                 415     


Glu Arg Ser Thr Met Ser Leu Pro Pro Gly Leu Leu Gly Asn Ser Trp 
            420                 425                 430         


Gly Glu Gly Ala Pro Ala Trp Val Leu Leu Asp Glu Cys Gly Leu Glu 
        435                 440                 445             


Leu Gly Glu Asp Thr Pro His Val Cys Trp Glu Pro Gln Ala Gln Gly 
    450                 455                 460                 


Arg Met Cys Ala Leu Tyr Ala Ser Leu Ala Leu Leu Ser Gly Leu Ser 
465                 470                 475                 480 


Gln Glu Pro His 
                


<210>  8
<211>  1823
<212>  DNA
<213>  Homo sapiens

<400>  8
cctgggcggg ccctgcgtca ggttgcagtt tcacttttag ctctgggcac ctccagctcc       60

tgctcgccgg acggctccca gggagagcag acgcgccaga cgcgccaccc tcggggcgcc      120

gacggtcacg gagcatgggg tcggcctttg agcgggtagt ccggagagtg gtccaggagc      180

tggaccatgg tggggagttc atccctgtga ccagcctgca gagctccact ggcttccagc      240

cctactgcct ggtggttagg aagccctcaa gctcatggtt ctggaaaccc cgttataagt      300

gtgtcaacct gtctatcaag gacatcctgg agccggatgc cgcggaacca gacgtgcagc      360

gtggcaggag cttccacttc tacgatgcca tggatgggca gatacagggc agcgtggagc      420

tggcagcccc aggacaggca aagatcgcag gcggggccgc ggtgtctgac agctccagca      480

cctcaatgaa tgtgtactcg ctgagtgtgg accctaacac ctggcagact ctgctccatg      540

agaggcacct gcggcagcca gaacacaaag tcctgcagca gctgcgcagc cgcggggaca      600

acgtgtacgt ggtgactgag gtgctacaga cacagaagga ggtggaagtc acgcgcaccc      660

acaagcggga gggctcgggc cggttttccc tgcccggagc cacgtgcttg cagggtgagg      720

gccagggcca tctgagccag aagaagacgg tcaccatccc ctcaggcagc accctcgcat      780

tccgggtggc ccagctggtt attgactctg acttggacgt ccttctcttc ccggataaga      840

agcagaggac cttccagcca cccgcgacag gccacaagcg ttccacgagc gaaggcgcct      900

ggccacagct gccctctggc ctctccatga tgaggtgcct ccacaacttc ctgacagatg      960

gggtccctgc ggagggggcg ttcactgaag acttccaggg cctacgggca gaggtggaga     1020

ccatctccaa ggaactggag cttttggaca gagagctgtg ccagctgctg ctggagggcc     1080

tggagggggt gctgcgggac cagctggccc tgcgagcctt ggaggaggcg ctggagcagg     1140

gccagagcct tgggccggtg gagcccctgg acggtccagc aggtgctgtc ctggagtgcc     1200

tggtgttgtc ctccggaatg ctggtgccgg aactcgctat ccctgttgtc tacctgctgg     1260

gggcactgac catgctgagt gaaacgcagc acaagctgct ggcggaggcg ctggagtcgc     1320

agaccctgtt ggggccgctc gagctggtgg gcagcctctt ggagcagagt gccccgtggc     1380

aggagcgcag caccatgtcc ctgccccccg ggctcctggg gaacagctgg ggcgaaggag     1440

caccggcctg ggtcttgctg gacgagtgtg gcctagagct gggggaggac actccccacg     1500

tgtgctggga gccgcaggcc cagggccgca tgtgtgcact ctacgcctcc ctggcactgc     1560

tatcaggact gagccaggag ccccactagc ctgtgcccgg gcatggcctg gcagctctcc     1620

agcagggcag agtgtttgcc caccagctgc tagccctagg aaggccagga gcccagtagc     1680

catgtggcca gtctaccatg gggcccagga gttggggaaa cacaataaag gtggcatacg     1740

aaggaaaaaa aaaaaaaaaa aaaaaccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaa                                             1823


<210>  9
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  9
guguagaugu agaagagaat t                                                 21


<210>  10
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  10
ccuagaggaa gaugcuguut t                                                 21


<210>  11
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  11
cuacacugug guugacgaa                                                    19


<210>  12
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  12
ccauagaacg agcaaccuu                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  13
cagcagaauc uacaaauau                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  14
cggaugugcu gcuuuauga                                                    19


<210>  15
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  15
ccggcctgct gtaacacttc ttattctcga gaataagaag tgttacagca ggttttttg        59


<210>  16
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  16
ccggagacta tgtaaagaaa gagctctcga gagctctttc tttacatagt ctttttt          57


<210>  17
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  17
ccggccaaca ttcgcttcct ggatactcga gtatccagga agcgaatgtt ggttttttg        59


<210>  18
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  18
ccggctgtgg ccagttgagc taatcctcga ggattagctc aactggccac agtttttg         58


<210>  19
<211>  59
<212>  DNA
<213>  Homo sapiens

<400>  19
ccggcaacct gtctatcaag gacatctcga gatgtccttg atagacaggt tgttttttg        59


<210>  20
<211>  57
<212>  DNA
<213>  Homo sapiens

<400>  20
ccggcagagt ggaaatccta aggaactcga gttccttagg atttccactc tgttttt          57


<210>  21
<211>  58
<212>  DNA
<213>  Homo sapiens

<400>  21
ccgggccaag attcaggaaa ttattctcga gaataatttc ctgaatcttg gctttttg         58


