                         SEQUENCE LISTING

<110>  Cellectis
 
<120>  Improved anti-CD123 CAR in universal engineered immune T cells

<130>  P81703926PCT00

<150>  PA201770765
<151>  2017-10-09

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  1

Gly Gly Gly Gly Ser 
1               5   


<210>  2
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  3

Cys Pro Tyr Ser Asn Pro Ser Leu Cys 
1               5                   


<210>  4
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  4

Asn Ser Glu Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp 
1               5                   10                  15      


Gln Lys Lys Leu Met Ser Asn Asn 
            20                  


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  5

Cys Gln Phe Asp Leu Ser Thr Arg Arg Leu Lys 
1               5                   10      


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  6

Cys Gln Tyr Asn Leu Ser Ser Arg Ala Leu Lys Cys 
1               5                   10          


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  7

Cys Val Trp Gln Arg Trp Gln Lys Ser Tyr Val Cys 
1               5                   10          


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  8

Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp 
1               5                   10                  15      


Lys Leu Ala Ala Phe Pro Glu Asp Arg 
            20                  25  


<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  9

Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln 
1               5                   10                  15      


Ile Lys Glu 
            


<210>  10
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  10

Glu Leu Pro Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser 
1               5                   10                  15      


Pro Ala Lys Pro Thr Thr Thr Ala 
            20                  


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAB-specific epitope

<400>  11

Gly Gln Asn Asp Thr Ser Gln Thr Ser Ser Pro Ser 
1               5                   10          


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  12

Gly Gly Gly Ser 
1               


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  13

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative signal peptide

<400>  16

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  17
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  18
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  18

Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  19
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  19

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  20
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  20

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  21
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  22
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  22

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  23
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Ser Gly Gly Ser 
1               


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Ser Ser Gly Gly Ser 
1               5   


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Gly Gly Gly Gly 
1               


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  26

Ser Gly Gly Gly Gly 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  27

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  28

Gly Gly Gly Gly Gly Ser 
1               5       


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  29

Ser Gly Gly Gly Gly Gly Ser 
1               5           


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  30

Ser Gly Gly Gly Gly Gly 
1               5       


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  31

Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  32

Gly Gly Gly Gly Gly Gly Gly Ser 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  33

Ser Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  34

Ser Gly Gly Gly Gly Gly Gly Gly Ser 
1               5                   


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  35

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  36
<211>  16
<212>  DNA
<213>  Homo sapiens

<400>  36
ttgtcccaca gatatc                                                       16


<210>  37
<211>  17
<212>  DNA
<213>  Homo sapiens

<400>  37
ccgtgtacca gctgaga                                                      17


