                         SEQUENCE LISTING

<110>   Beijing Biocytogen Co., Ltd
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC PD-1

<130>  1

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  1972
<212>  DNA/RNA
<213>  Mouse

<400>  1
tgagcagcgg ggaggaggaa gaggagactg ctactgaagg cgacactgcc aggggctctg       60

ggcatgtggg tccggcaggt accctggtca ttcacttggg ctgtgctgca gttgagctgg      120

caatcagggt ggcttctaga ggtccccaat gggccctgga ggtccctcac cttctaccca      180

gcctggctca cagtgtcaga gggagcaaat gccaccttca cctgcagctt gtccaactgg      240

tcggaggatc ttatgctgaa ctggaaccgc ctgagtccca gcaaccagac tgaaaaacag      300

gccgccttct gtaatggttt gagccaaccc gtccaggatg cccgcttcca gatcatacag      360

ctgcccaaca ggcatgactt ccacatgaac atccttgaca cacggcgcaa tgacagtggc      420

atctacctct gtggggccat ctccctgcac cccaaggcaa aaatcgagga gagccctgga      480

gcagagctcg tggtaacaga gagaatcctg gagacctcaa caagatatcc cagcccctcg      540

cccaaaccag aaggccggtt tcaaggcatg gtcattggta tcatgagtgc cctagtgggt      600

atccctgtat tgctgctgct ggcctgggcc ctagctgtct tctgctcaac aagtatgtca      660

gaggccagag gagctggaag caaggacgac actctgaagg aggagccttc agcagcacct      720

gtccctagtg tggcctatga ggagctggac ttccagggac gagagaagac accagagctc      780

cctaccgcct gtgtgcacac agaatatgcc accattgtct tcactgaagg gctgggtgcc      840

tcggccatgg gacgtagggg ctcagctgat ggcctgcagg gtcctcggcc tccaagacat      900

gaggatggac attgttcttg gcctctttga ccagattctt cagccattag catgctgcag      960

accctccaca gagagcaccg gtccgtccct cagtcaagag gagcatgcag gctacagttc     1020

agccaaggct cccagggtct gagctagctg gagtgacagc ccagcgcctg caccaattcc     1080

agcacatgca ctgttgagtg agagctcact tcaggtttac cacaagctgg gagcagcagg     1140

cttcccggtt tcctattgtc acaaggtgca gagctggggc ctaagcctat gtctcctgaa     1200

tcctactgtt gggcacttct agggacttga gacactatag ccaatggcct ctgtgggttc     1260

tgtgcctgga aatggagaga tctgagtaca gcctgctttg aatggccctg tgaggcaacc     1320

ccaaagcaag ggggtccagg tatactatgg gcccagcacc taaagccacc cttgggagat     1380

gatactcagg tgggaaattc gtagactggg ggactgaacc aatcccaaga tctggaaaag     1440

ttttgatgaa gacttgaaaa gctcctagct tcgggggtct gggaagcatg agcacttacc     1500

aggcaaaagc tccgtgagcg tatctgctgt ccttctgcat gcccaggtac ctcagttttt     1560

ttcaacagca aggaaactag ggcaataaag ggaaccagca gagctagagc cacccacaca     1620

tccagggggc acttgactct ccctactcct cctaggaacc aaaaggacaa agtccatgtt     1680

gacagcaggg aaggaaaggg ggatataacc ttgacgcaaa ccaacactgg ggtgttagaa     1740

tctcctcatt cactctgtcc tggagttggg ttctggctct ccttcacacc taggactctg     1800

aaatgagcaa gcacttcaga cagtcagggt agcaagagtc tagctgtctg gtgggcaccc     1860

aaaatgacca gggcttaagt ccctttcctt tggtttaagc ccgttataat taaatggtac     1920

caaaagcttt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1972


<210>  2
<211>  288
<212>  PRT
<213>  mouse

<400>  1
Met Trp Val Arg Gln Val Pro Trp Ser Phe Thr Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Ser Trp Gln Ser Gly Trp Leu Leu Glu Val Pro Asn Gly Pro Trp 
            20                  25                  30          
Arg Ser Leu Thr Phe Tyr Pro Ala Trp Leu Thr Val Ser Glu Gly Ala 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Leu Ser Asn Trp Ser Glu Asp Leu Met 
    50                  55                  60                  
Leu Asn Trp Asn Arg Leu Ser Pro Ser Asn Gln Thr Glu Lys Gln Ala 
65                  70                  75                  80  
Ala Phe Cys Asn Gly Leu Ser Gln Pro Val Gln Asp Ala Arg Phe Gln 
                85                  90                  95      
Ile Ile Gln Leu Pro Asn Arg His Asp Phe His Met Asn Ile Leu Asp 
            100                 105                 110         
Thr Arg Arg Asn Asp Ser Gly Ile Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
His Pro Lys Ala Lys Ile Glu Glu Ser Pro Gly Ala Glu Leu Val Val 
    130                 135                 140                 
Thr Glu Arg Ile Leu Glu Thr Ser Thr Arg Tyr Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Lys Pro Glu Gly Arg Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     
Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         
Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             
Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 
Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 
Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     
Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         
Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  3
<211>  867
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  3
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctga                                          867


<210>  4
<211>  867
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  4
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aggcatggtc attggtatca tgagtgccct agtgggtatc      540

cctgtattgc tgctgctggc ctgggcccta gctgtcttct gctcaacaag tatgtcagag      600

gccagaggag ctggaagcaa ggacgacact ctgaaggagg agccttcagc agcacctgtc      660

cctagtgtgg cctatgagga gctggacttc cagggacgag agaagacacc agagctccct      720

accgcctgtg tgcacacaga atatgccacc attgtcttca ctgaagggct gggtgcctcg      780

gccatgggac gtaggggctc agctgatggc ctgcagggtc ctcggcctcc aagacatgag      840

gatggacatt gttcttggcc tctttga                                          867


<210>  5
<211>  589
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  5
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  6
<211>  208
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  6
ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc       60

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc      120

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt      180

gggaagacaa tagcaggcat gctgggga                                         208


<210>  7
<211>  1400
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  7
gtcttgctac cctgagcatg ccagaaagac ataaaggtat aaaggaggct ctgtaacagc       60

caggcgtggg gaggggatcc ccctagcttc tgcccacagg ccccatgctg agactggagg      120

cggccagtct gtgcctcaca ctctttttcc atttctgtgc tgttcaaagt aatgtttcct      180

tccccaccaa gctagtgcct ctgaacctgg gtggctgagg cagttgccag atggtttcca      240

ggcgggctgc ctattttagg gtggtgagac ccacacatct cattgctaat attagcagtt      300

tcgttttccc tttttttccc attcactgtg gcgaaacaca gagagcagaa tgattaaatc      360

atcagaatgc cccagaaatg actagccagc caggtactat gcatgcacac aagtcggccc      420

accccaccta atcccagaga gacaagcagg aggtgaggtg ggcctccacc tcctagggac      480

tgaggaaagt tgactgggaa agacctagaa attgagtcta ccccagcctg gtgttaggtt      540

tttctcaggg gaagagaaag atgcagggca gcagagctag caaacctaag acaactatag      600

aagcagagaa aacagtgaga tccgggcagc agatccagca tcttgaaagg aagaaaagcc      660

ttaagagaaa gcaagaccag gcccagggtc tttctgaacc tacaggggtg tctggagagg      720

aaaggcatcg tctcgggtcc taggaaatgt tcactatagc ccttcgaggc ctcctctgac      780

ccatcaaacg ggagcatgtg ggatagctgg gctcttgctc ctcagtagta aaggactaag      840

gcatagctca gggcattcaa ggccacgcat ggcagacaag gtaggggagg gtccagcttg      900

ccctcgctgc ggccataggt accaaagcca ggcctcgaca cccaccctcc aaagggacaa      960

gagtctggcc ctagtttcag tctctctcag ccctgggagc taaggctcga tcggggtacc     1020

aggaatggaa aagaccaaac ctacccacaa gaggggctag aaatggagag gaccccatag     1080

caggacaaga ggcaaggaca gctagtcaga gagaaccccc cctctctgct ccccaatctc     1140

tcactagtcc cttacctgct cctcccaggc atcgttccct cccactcccc tcccccttcc     1200

atgcccctcc cccacctcta gttgcctgtt ctcccaccct tgtggaggtg gaggaagagg     1260

gggcgggagc caagaacagg tctcctccct ccaacatgac ctgggacagt ttcctttccg     1320

ctacagacaa ctctgcctga gcagcgggga ggaggaagag gagactgcta ctgaaggcga     1380

cactgccagg ggctctgggc                                                 1400


<210>  8
<211>  1400
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  8
gtatgtggct cctagggatg tgggatcaat tggggttggt ggctggggca gggcttgaag       60

aaacgttcac cctcggttcc tattactgga ggggaggaac acctgtgtcc ctggttacac      120

ggattggctc ctggttacac agattggctt taggtgggtt ttacaggtga aatgccccct      180

ggggctcaaa atccaccccc tccttgcttt tagacagaca gaacatttat ctaacgtcag      240

ttgatcttct gtgtccctct ctgtgaagcg atggtaggtc tgaacagagc tctgacctca      300

gccactgctt caggattctg gcaggccctg gtatccttgg cctttctcta tgtttttcta      360

tggttgggga catccctaca tggagcctgc cctacacact gtatagatga ctgaagatcc      420

aagagtataa tcagctgtct accctcatgg acaagcttcc cgtgctagca tttctggggg      480

actcccgagt tcatatccct ggcctcatag catcctgggg gtggggggtg tgtgaaacgg      540

agaggtccag gaatcctgct caaattcctc acagtgaaaa cacagctccc tgtactcctt      600

actcctcact accctgtacc ccttggcccc tgcccaccct ctggactgag ccaaccttca      660

ctgagaacct ggtcctggga ccagagggaa ctttgtttct cctggatgtc aacaaactcc      720

taggtcagag ctacacctgc ggcgcatgga attgtggcct agacaagctt atactcttgt      780

gctgccttaa catctttgac ctgcaatgat gttcctttgc tcatatgacg tcccagtcac      840

cttcacccca gcctcttcac taccgtgaaa acaggatggg actgggagct gggtgctggg      900

tgcttaccac cacaggccct ctcctgggtt gcaggctaag gctggttggg aagccaggga      960

cattttccct ccacgtaccc tcttaagata gcccatggtt tgctgtcaag actggatgga     1020

ggaaacagac ctgaacatgg tagatggtct gaggccctag ggtgaaagat gtcccttggg     1080

gaaaccttgt caggaaaccc acggagcaaa gtcggaagga ttatgtgtca ttggagagaa     1140

gcaactgaga cagaaagggg actatgactc actctggtga cctggcacac tgggcatgtc     1200

cgcaaatgaa gctttgatga gacaatatgg agatacagat gtatttatgc aggcctactg     1260

tagattgtct ctgacaaatg tctcaaagtg gcatgcctcc ttcacgacct gaatagctca     1320

acgtgggaca cctcacaggc cagtgccatt tggcagccgt ggacctttag tctagtgcat     1380

ttcttccctc ctgattggcc                                                 1400


<210>  9
<211>  1696
<212>  DNA
<213>  Artificial Sequence

<400>  9
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aaccctggtg gttggtgtcg tgggcggcct gctgggcagc      540

ctggtgctgc tagtctgggt cctggccgtc atctgctccc gggccgcacg agggacaata      600

ggagccaggc gcaccggcca gcccctgaag gaggacccct cagccgtgcc tgtgttctct      660

gtggactatg gggagctgga tttccagtgg cgagagaaga ccccggagcc ccccgtgccc      720

tgtgtccctg agcagacgga gtatgccacc attgtctttc ctagcggaat gggcacctca      780

tcccccgccc gcaggggctc agctgacggc cctcggagtg cccagccact gaggcctgag      840

gatggacact gctcttggcc cctctgaaat caacctctgg attacaaaat ttgtgaaaga      900

ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg      960

cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc     1020

tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc     1080

actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt     1140

tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt     1200

gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg     1260

aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg     1320

tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg     1380

ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt     1440

tgggccgcct ccccgcatcg ataccgtcga cctcgactgt gccttctagt tgccagccat     1500

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     1560

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     1620

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     1680

gggaattaat agtact                                                     1696


<210>  10
<211>  1740
<212>  DNA
<213>  Artificial Sequence

<400>  10
cgacactgcc aggggctctg ggcatgcaga tcccacaggc gccctggcca gtcgtctggg       60

cggtgctaca actgggctgg cggccaggat ggttcttaga ctccccagac aggccctgga      120

acccccccac cttctcccca gccctgctcg tggtgaccga aggggacaac gccaccttca      180

cctgcagctt ctccaacaca tcggagagct tcgtgctaaa ctggtaccgc atgagcccca      240

gcaaccagac ggacaagctg gccgccttcc ccgaggaccg cagccagccc ggccaggact      300

gccgcttccg tgtcacacaa ctgcccaacg ggcgtgactt ccacatgagc gtggtcaggg      360

cccggcgcaa tgacagcggc acctacctct gtggggccat ctccctggcc cccaaggcgc      420

agatcaaaga gagcctgcgg gcagagctca gggtgacaga gagaagggca gaagtgccca      480

cagcccaccc cagcccctca cccaggccag ccggccagtt ccaaaccctg gtggttggtg      540

tcgtgggcgg cctgctgggc agcctggtgc tgctagtctg ggtcctggcc gtcatctgct      600

cccgggccgc acgagggaca ataggagcca ggcgcaccgg ccagcccctg aaggaggacc      660

cctcagccgt gcctgtgttc tctgtggact atggggagct ggatttccag tggcgagaga      720

agaccccgga gccccccgtg ccctgtgtcc ctgagcagac ggagtatgcc accattgtct      780

ttcctagcgg aatgggcacc tcatcccccg cccgcagggg ctcagctgac ggccctcgga      840

gtgcccagcc actgaggcct gaggatggac actgctcttg gcccctctga aatcaacctc      900

tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct ccttttacgc      960

tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt atggctttca     1020

ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg tggcccgttg     1080

tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact ggttggggca     1140

ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct attgccacgg     1200

cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg ttgggcactg     1260

acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg     1320

ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc aatccagcgg     1380

accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc     1440

ctcagacgag tcggatctcc ctttgggccg cctccccgca tcgataccgt cgacctcgac     1500

tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct     1560

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct     1620

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg     1680

ggaagacaat agcaggcatg ctggggaatt aatagtactg tatgtggctc ctagggatgt     1740


<210>  11
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  11
tctgggcatg tgggtccggc agg                                               23


<210>  12
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  12
tgtgggtccg gcaggtaccc tgg                                               23


<210>  13
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  13
ctgcagttga gctggcaatc agg                                               23


<210>  14
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  14
aggtaccctg gtcattcact tgg                                               23


<210>  15
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  15
tgaatgacca gggtacctgc cgg                                               23


<210>  16
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  16
agttgagctg gcaatcaggg tgg                                               23


<210>  17
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  17
cagggtggct tctaggtatg tgg                                               23


<210>  18
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  18
acagcccaag tgaatgacca ggg                                               23


<210>  19
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  19
gccaggggct ctgggcatgt ggg                                               23


<210>  20
<211>  18
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  20
ttgagctggc aatcaggg                                                     18


<210>  21
<211>  18
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  21
ccctgattgc cagctcaa                                                     18


<210>  22
<211>  140
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  22
gtaaaacgac ggccagtgaa ttctaatacg actcactata ggttgagctg gcaatcaggg       60

gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt      120

ggcaccgagt cggtgctttt                                                  140


<210>  23
<211>  25
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  23
ccagaagaag gtacagcaga agggg                                             25


<210>  24
<211>  25
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  24
aagcagcgta tccacatagc gtaaa                                             25


<210>  25
<211>  25
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  25
gtgcctgtgt tctctgtgga ctatg                                             25


<210>  26
<211>  25
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  26
ctggtcttga actttgatgg gcacg                                             25


<210>  27
<211>  25
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  27
tcaacctccc aatgctaacc agaac                                             25


<210>  28
<211>  25
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  28
cagactgttg gatcaagtgc tgtct                                             25


<210>  29
<211>  22
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  29
gtggatacgc tgctttaatg cc                                                22


<210>  30
<211>  23
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  30
aagggagatc cgactcgtct gag                                               23


<210>  31
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  31
cctggctcac agtgtcagag                                                   20


<210>  32
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  32
cagggctctc ctcgattttt                                                   20


<210>  33
<211>  288
<212>  PRT
<213>  Artificial Sequence

<400>  33

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Gly Met Val Ile Gly Ile Met Ser Ala 
                165                 170                 175     


Leu Val Gly Ile Pro Val Leu Leu Leu Leu Ala Trp Ala Leu Ala Val 
            180                 185                 190         


Phe Cys Ser Thr Ser Met Ser Glu Ala Arg Gly Ala Gly Ser Lys Asp 
        195                 200                 205             


Asp Thr Leu Lys Glu Glu Pro Ser Ala Ala Pro Val Pro Ser Val Ala 
    210                 215                 220                 


Tyr Glu Glu Leu Asp Phe Gln Gly Arg Glu Lys Thr Pro Glu Leu Pro 
225                 230                 235                 240 


Thr Ala Cys Val His Thr Glu Tyr Ala Thr Ile Val Phe Thr Glu Gly 
                245                 250                 255     


Leu Gly Ala Ser Ala Met Gly Arg Arg Gly Ser Ala Asp Gly Leu Gln 
            260                 265                 270         


Gly Pro Arg Pro Pro Arg His Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  34
<211>  2115
<212>  DNA/RNA
<213>  human

<400>  34
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115


<210>  35
<211>  288
<212>  PRT
<213>  human

<400>  35

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  36
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<400>  36
tgccaggggc tctgggcatg cagatcccac aggcgccctg gccagtcgtc tgggcggtgc       60

tacaactggg ctggcggcca ggatggttct tagactcccc agacaggccc tggaaccccc      120

ccaccttctc cccagccctg ctcgtggtga ccgaagggga caacgccacc ttcacctgca      180

gcttctccaa cacatcggag agcttcgtgc taaactggta ccgcatgagc cccagcaacc      240

agacggacaa gctggccgcc ttccccgagg accgcagcca gcccggccag gactgccgct      300

tccgtgtcac acaactgccc aacgggcgtg acttccacat gagcgtggtc agggcccggc      360

gcaatgacag cggcacctac ctctgtgggg ccatctccct ggcccccaag gcgcagatca      420

aagagagcct gcgggcagag ctcagggtga cagagagaag ggcagaagtg cccacagccc      480

accccagccc ctcacccagg ccagccggcc agttccaagg catggtcatt ggtatcatga      540

gtgccctagt gggtatccct gtattgctgc tgctggcctg ggccctagct gtcttctgct      600

caacaagtat gtcagaggcc agaggagctg gaagcaagga cgacactctg aaggaggagc      660

cttcagcagc acctgtccct agtgtggcct atgaggagct ggacttccag ggacgagaga      720

agacaccaga gctccctacc gcctgtgtgc acacagaata tgccaccatt gtcttcactg      780

aagggctggg tgcctcggcc atgggacgta ggggctcagc tgatggcctg cagggtcctc      840

ggcctccaag acatgaggat ggacattgtt cttggcctct ttgaaatcaa cctctggatt      900

acaaaatttg tgaaagattg actggtattc ttaactatgt tgctcctttt acgctatgtg      960

gatacgctgc tttaatgcct ttgtatcatg ctattgcttc ccgtatggct ttcattttct     1020

cctccttgta taaatcctgg ttgctgtctc tttatgagga gttgtggccc gttgtcaggc     1080

aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc cactggttgg ggcattgcca     1140

ccacctgtca gctcctttcc gggactttcg ctttccccct ccctattgcc acggcggaac     1200

tcatcgccgc ctgccttgcc cgctgctgga caggggctcg gctgttgggc actgacaatt     1260

ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct gctcgcctgt gttgccacct     1320

ggattctgcg cgggacgtcc ttctgctacg tcccttcggc cctcaatcca gcggaccttc     1380

cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga     1440

cgagtcggat ctccctttgg gccgcctccc cgcatcgata ccgtcgacct cgactgtgcc     1500

ttctagttgc cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg     1560

tgccactccc actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag     1620

gtgtcattct attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga     1680

caatagcagg catgctgggg aattaatagt actgtatgtg gc                        1722


<210>  37
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  37
ccctgctcgt ggtgaccgaa                                                   20


<210>  38
<211>  20
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  38
gcaggctctc tttgatctgc                                                   20


<210>  39
<211>  1696
<212>  DNA
<213>  Artificial Sequence

<400>  39
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg       60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc      120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg      180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc      240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg      300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc      360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca      420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc      480

aggccagccg gccagttcca aggcatggtc attggtatca tgagtgccct agtgggtatc      540

cctgtattgc tgctgctggc ctgggcccta gctgtcttct gctcaacaag tatgtcagag      600

gccagaggag ctggaagcaa ggacgacact ctgaaggagg agccttcagc agcacctgtc      660

cctagtgtgg cctatgagga gctggacttc cagggacgag agaagacacc agagctccct      720

accgcctgtg tgcacacaga atatgccacc attgtcttca ctgaagggct gggtgcctcg      780

gccatgggac gtaggggctc agctgatggc ctgcagggtc ctcggcctcc aagacatgag      840

gatggacatt gttcttggcc tctttgaaat caacctctgg attacaaaat ttgtgaaaga      900

ttgactggta ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg      960

cctttgtatc atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc     1020

tggttgctgt ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc     1080

actgtgtttg ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt     1140

tccgggactt tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt     1200

gcccgctgct ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg     1260

aaatcatcgt cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg     1320

tccttctgct acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg     1380

ccggctctgc ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt     1440

tgggccgcct ccccgcatcg ataccgtcga cctcgactgt gccttctagt tgccagccat     1500

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     1560

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     1620

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     1680

gggaattaat agtact                                                     1696


<210>  40
<211>  80
<212>  DNA/RNA
<213>  Artificial Sequence

<400>  40
gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc tcggctgttg       60

ggcactgaca attccgtggt                                                   80

