                               SEQUENCE LISTING

<110> MCMASTER UNIVERSITY
 
<120> T CELL-ANTIGEN COUPLER WITH Y182T MUTATION AND METHODS AND USES 
      THEREOF

<130> 27109-P57378PC00

<150> US 62/571,354
<151> 2017-10-12

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 1575
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atggatttcc aggtccagat tttctccttc ctgctgattt ccgcaagcgt cattatgtca       60

cggggctccg acctgggcaa aaagctgctg gaggccgcta gggccgggca ggacgatgaa      120

gtgagaatcc tgatggccaa cggggctgac gtgaatgcta aggatgagta cggcctgacc      180

cccctgtatc tggctacagc acacggccat ctggagatcg tggaagtcct gctgaaaaac      240

ggagccgacg tgaatgcagt cgatgccatt gggttcactc ctctgcacct ggcagccttt      300

atcggacatc tggagattgc agaagtgctg ctgaagcacg gcgctgacgt gaacgcacag      360

gataagttcg gaaaaaccgc ttttgacatc agcattggca acggaaatga agacctggct      420

gaaatcctgc agaaactgaa tgaacagaaa ctgattagcg aagaagacct gaaccccggg      480

ggaggaggag ggagcggggg aggaggcagc ggcgggggag gctctggagg aggagggagc      540

ggatccatgg acatccagat gactcagacc acaagctccc tgtctgcaag tctgggcgac      600

cgggtgacaa tctcctgcag agcctctcag gatattagga actacctgaa ttggtatcag      660

cagaaacctg atggcacagt caagctgctg atctactata ccagccggct gcactcaggc      720

gtgccaagca aattctcagg aagcggctcc gggactgact actccctgac catctctaac      780

ctggagcagg aagatattgc tacctatttc tgccagcagg gcaatacact gccctggact      840

tttgccggag gcaccaaact ggagatcaag gggggaggcg ggagtggagg cgggggatca      900

ggaggaggag gcagcggagg aggagggtcc gaggtccagc tgcagcagag cggaccagaa      960

ctggtgaagc ccggagcaag tatgaaaatc tcctgtaagg cctcaggata cagcttcacc     1020

ggctatacaa tgaactgggt gaaacagtcc catggcaaga acctggaatg gatggggctg     1080

attaatcctt acaaaggcgt cagcacctat aatcagaagt ttaaagacaa ggccacactg     1140

actgtggata agtctagttc aaccgcttac atggagctgc tgtccctgac atctgaagac     1200

agtgccgtgt actattgtgc tcggtctggc tactatgggg acagtgattg gtacttcgat     1260

gtctggggac agggcactac cctgaccgtg ttttctacta gtggcggagg aggatcactc     1320

gagagcggac aggtgctgct ggaatccaat atcaaagtcc tgcccacttg gtctaccccc     1380

gtgcagccta tggctctgat tgtgctggga ggagtcgcag gactgctgct gtttatcggg     1440

ctgggaattt tcttttgcgt gcgctgccgg caccggagaa ggcaggccga gcgcatgagc     1500

cagatcaagc gactgctgag cgagaagaaa acctgtcagt gtccccatag attccagaag     1560

acctgttcac ccatt                                                      1575


<210> 2
<211> 525
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
            20                  25                  30          


Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly 
        35                  40                  45              


Ala Asp Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu 
    50                  55                  60                  


Ala Thr Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn 
65                  70                  75                  80  


Gly Ala Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His 
                85                  90                  95      


Leu Ala Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys 
            100                 105                 110         


His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe 
        115                 120                 125             


Asp Ile Ser Ile Gly Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
    130                 135                 140                 


Lys Leu Asn Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Pro Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Ser Met Asp Ile Gln Met Thr Gln Thr Thr Ser 
            180                 185                 190         


Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala 
        195                 200                 205             


Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp 
    210                 215                 220                 


Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly 
225                 230                 235                 240 


Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu 
                245                 250                 255     


Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln 
            260                 265                 270         


Gln Gly Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu 
        275                 280                 285             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
305                 310                 315                 320 


Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly 
                325                 330                 335     


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
            340                 345                 350         


Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser 
        355                 360                 365             


Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
    370                 375                 380                 


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
385                 390                 395                 400 


Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp 
                405                 410                 415     


Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
            420                 425                 430         


Thr Ser Gly Gly Gly Gly Ser Leu Glu Ser Gly Gln Val Leu Leu Glu 
        435                 440                 445             


Ser Asn Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met 
    450                 455                 460                 


Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly 
465                 470                 475                 480 


Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala 
                485                 490                 495     


Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys 
            500                 505                 510         


Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
        515                 520                 525 


<210> 3
<211> 1647
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atggactttc aggtgcagat tttctctttt ctgctgattt ccgcaagcgt catcgagctc       60

gggggggggg ggtcaggatc catggacatc cagatgactc agaccacaag ctccctgagc      120

gcatccctgg gcgaccgagt gacaatctca tgcagagcca gccaggatat taggaactac      180

ctgaattggt atcagcagaa acctgacggc acagtcaagc tgctgatcta ctatacttcc      240

cggctgcact ctggcgtgcc aagtaaattc tctgggagtg gatcaggcac tgactactca      300

ctgaccatca gcaacctgga gcaggaagat attgctacct atttctgcca gcagggcaat      360

acactgccct ggacttttgc aggcgggacc aaactggaga tcaagggcgg cggcggaagt      420

ggaggaggag gctcaggcgg aggagggagc ggcggaggag gcagcgaggt ccagctgcag      480

cagagcggac cagaactggt gaagcctggc gcatccatga aaatctcttg taaggcctct      540

gggtacagtt tcaccggata tacaatgaac tgggtgaaac agtctcatgg caagaacctg      600

gaatggatgg gcctgattaa tccttacaaa ggcgtcagca cctataatca gaagtttaaa      660

gacaaggcca cactgactgt ggataagtct agttcaaccg cttacatgga gctgctgtca      720

ctgacaagcg aagactccgc cgtgtactat tgcgctagga gcggatacta tggcgactcc      780

gattggtact tcgatgtctg ggggcaggga actaccctga ccgtgtttag cactagtgga      840

ggaggaggct ctggaggagg agggagtgga ggcgggggat caggaggagg aggcagcgat      900

atcatgtcac ggggctccga cctgggcaaa aagctgctgg aggccgctag ggccgggcag      960

gacgatgaag tgagaatcct gatggccaac ggggctgacg tgaatgctaa ggatgagtac     1020

ggcctgaccc ccctgtatct ggctacagca cacggccatc tggagatcgt ggaagtcctg     1080

ctgaaaaacg gagccgacgt gaatgcagtc gatgccattg ggttcactcc tctgcacctg     1140

gcagccttta tcggacatct ggagattgca gaagtgctgc tgaagcacgg cgctgacgtg     1200

aacgcacagg ataagttcgg aaaaaccgct tttgacatca gcattggcaa cggaaatgaa     1260

gacctggctg aaatcctgca gaaactgaat gaacagaaac tgattagcga agaagacctg     1320

aacgtcgacg gaggaggagg gtctggagga gggggaagtg gcgggggagg cagcggggga     1380

ggcgggtctc tcgagagtgg ccaggtgctg ctggaaagca atatcaaggt cctgccaact     1440

tggtccaccc cagtgcagcc tatggctctg attgtgctgg gaggagtcgc aggactgctg     1500

ctgtttatcg gcctggggat tttcttttgc gtgcgctgcc ggcaccggag aaggcaggct     1560

gagcgcatgt ctcagattaa gcgactgctg agcgagaaga agacctgtca gtgcccccat     1620

agattccaga aaacctgttc acccatt                                         1647


<210> 4
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Glu Leu Gly Gly Gly Gly Ser Gly Ser Met Asp Ile Gln Met 
            20                  25                  30          


Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr 
        35                  40                  45              


Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn Tyr Leu Asn Trp Tyr 
    50                  55                  60                  


Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser 
65                  70                  75                  80  


Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser Gly Ser Gly Ser Gly 
                85                  90                  95      


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
            100                 105                 110         


Thr Tyr Phe Cys Gln Asn Thr Leu Pro Trp Thr Phe Ala Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys 
                165                 170                 175     


Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln 
            180                 185                 190         


Ser His Gly Lys Asn Leu Glu Trp Met Gly Leu Ile Asn Pro Tyr Lys 
        195                 200                 205             


Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
    210                 215                 220                 


Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr Tyr Gly 
                245                 250                 255     


Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Leu Thr 
            260                 265                 270         


Val Phe Ser Thr Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Met Ser Arg Gly Ser 
    290                 295                 300                 


Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
305                 310                 315                 320 


Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
                325                 330                 335     


Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr Ala His Gly His Leu 
            340                 345                 350         


Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Val 
        355                 360                 365             


Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala Ala Phe Ile Gly His 
    370                 375                 380                 


Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
385                 390                 395                 400 


Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Gly Asn Gly 
                405                 410                 415     


Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn Glu Gln Lys Leu 
            420                 425                 430         


Ile Ser Glu Glu Asp Leu Asn Val Asp Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Ser 
    450                 455                 460                 


Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp Ser 
465                 470                 475                 480 


Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly 
                485                 490                 495     


Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg 
            500                 505                 510         


His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu 
        515                 520                 525             


Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys 
    530                 535                 540                 


Ser Pro Ile 
545         


<210> 5
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
atggatttcc aggtccagat tttctccttc ctgctgattt ccgcaagcgt catt             54


<210> 6
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile 
        


<210> 7
<211> 387
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgtcacggg gctccgacct gggcaaaaag ctgctggagg ccgctagggc cgggcaggac       60

gatgaagtga gaatcctgat ggccaacggg gctgacgtga atgctaagga tgagtacggc      120

ctgacccccc tgtatctggc tacagcacac ggccatctgg agatcgtgga agtcctgctg      180

aaaaacggag ccgacgtgaa tgcagtcgat gccattgggt tcactcctct gcacctggca      240

gcctttatcg gacatctgga gattgcagaa gtgctgctga agcacggcgc tgacgtgaac      300

gcacaggata agttcggaaa aaccgctttt gacatcagca ttggcaacgg aaatgaagac      360

ctggctgaaa tcctgcagaa actgaat                                          387


<210> 8
<211> 129
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Ser Arg Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
1               5                   10                  15      


Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
            20                  25                  30          


Val Asn Ala Lys Asp Glu Tyr Gly Leu Thr Pro Leu Tyr Leu Ala Thr 
        35                  40                  45              


Ala His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala 
    50                  55                  60                  


Asp Val Asn Ala Val Asp Ala Ile Gly Phe Thr Pro Leu His Leu Ala 
65                  70                  75                  80  


Ala Phe Ile Gly His Leu Glu Ile Ala Glu Val Leu Leu Lys His Gly 
                85                  90                  95      


Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
            100                 105                 110         


Ser Ile Gly Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
        115                 120                 125             


Asn 
    


<210> 9
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
gaacagaaac tgattagcga agaagacctg                                        30


<210> 10
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 11
<211> 75
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
aaccccgggg gaggaggagg gagcggggga ggaggcagcg gcgggggagg ctctggagga       60

ggagggagcg gatcc                                                        75


<210> 12
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Asn Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            20                  25  


<210> 13
<211> 750
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgctaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

acaatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

ccttacaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210> 14
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210> 15
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
actagtggcg gaggaggatc actcgag                                           27


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Thr Ser Gly Gly Gly Gly Ser Leu Glu 
1               5                   


<210> 17
<211> 252
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
agcggacagg tgctgctgga atccaatatc aaagtcctgc ccacttggtc tacccccgtg       60

cagcctatgg ctctgattgt gctgggagga gtcgcaggac tgctgctgtt tatcgggctg      120

ggaattttct tttgcgtgcg ctgccggcac cggagaaggc aggccgagcg catgagccag      180

atcaagcgac tgctgagcga gaagaaaacc tgtcagtgtc cccatagatt ccagaagacc      240

tgttcaccca tt                                                          252


<210> 18
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro Met Ala Leu Ile Val Leu Gly Gly Val Ala 
            20                  25                  30          


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
        35                  40                  45              


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
    50                  55                  60                  


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
65                  70                  75                  80  


Cys Ser Pro Ile 
                


<210> 19
<211> 66
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
agcggacagg tgctgctgga atccaatatc aaagtcctgc ccacttggtc tacccccgtg       60

cagcct                                                                  66


<210> 20
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr Trp 
1               5                   10                  15      


Ser Thr Pro Val Gln Pro 
            20          


<210> 21
<211> 801
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 21
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtct       60

agagacatcg tgctgaccca gagccccccc agcctggcca tgtctctggg caagagagcc      120

accatcagct gccgggccag cgagagcgtg accatcctgg gcagccacct gatccactgg      180

tatcagcaga agcccggcca gccccccacc ctgctgatcc agctcgccag caatgtgcag      240

accggcgtgc ccgccagatt cagcggcagc ggcagcagaa ccgacttcac cctgaccatc      300

gaccccgtgg aagaggacga cgtggccgtg tactactgcc tgcagagccg gaccatcccc      360

cggacctttg gcggaggcac caaactggaa atcaagggca gcaccagcgg ctccggcaag      420

cctggctctg gcgagggcag cacaaaggga cagattcagc tggtgcagag cggccctgag      480

ctgaagaaac ccggcgagac agtgaagatc agctgcaagg cctccggcta caccttcacc      540

gactacagca tcaactgggt gaaaagagcc cctggcaagg gcctgaagtg gatgggctgg      600

atcaacaccg agacaagaga gcccgcctac gcctacgact tccggggcag attcgccttc      660

agcctggaaa ccagcgccag caccgcctac ctgcagatca acaacctgaa gtacgaggac      720

accgccacct acttttgcgc cctggactac agctacgcca tggactactg gggccagggc      780

accagcgtga ccgtgtccag c                                                801


<210> 22
<211> 267
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            260                 265         


<210> 23
<211> 750
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgttaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

ccgatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

ccttacaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210> 24
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Val Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Pro Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210> 25
<211> 750
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
atggacatcc agatgactca gaccacaagc tccctgtctg caagtctggg cgaccgggtg       60

acaatctcct gcagagcctc tcaggatatt aggaactacc tgaattggta tcagcagaaa      120

cctgatggca cagtcaagct gctgatctac tataccagcc ggctgcactc aggcgtgcca      180

agcaaattct caggaagcgg ctccgggact gactactccc tgaccatctc taacctggag      240

caggaagata ttgctaccta tttctgccag cagggcaata cactgccctg gacttttgcc      300

ggaggcacca aactggagat caagggggga ggcgggagtg gaggcggggg atcaggagga      360

ggaggcagcg gaggaggagg gtccgaggtc cagctgcagc agagcggacc agaactggtg      420

aagcccggag caagtatgaa aatctcctgt aaggcctcag gatacagctt caccggctat      480

acaatgaact gggtgaaaca gtcccatggc aagaacctgg aatggatggg gctgattaat      540

cctaccaaag gcgtcagcac ctataatcag aagtttaaag acaaggccac actgactgtg      600

gataagtcta gttcaaccgc ttacatggag ctgctgtccc tgacatctga agacagtgcc      660

gtgtactatt gtgctcggtc tggctactat ggggacagtg attggtactt cgatgtctgg      720

ggacagggca ctaccctgac cgtgttttct                                       750


<210> 26
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Lys Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu 
65                  70                  75                  80  


Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Ala Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
    130                 135                 140                 


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
145                 150                 155                 160 


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Met 
                165                 170                 175     


Gly Leu Ile Asn Pro Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe 
            180                 185                 190         


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
        195                 200                 205             


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Ser Gly Tyr Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Thr Leu Thr Val Phe Ser 
                245                 250 


<210> 27
<211> 735
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
atggatatcc agatgaccca gtccccgagc tccctgtccg cctctgtggg cgatagggtc       60

accatcacct gccgtgccag tcaggacatc cgtaattatc tgaactggta tcaacagaaa      120

ccaggaaaag ctccgaaact actgatttac tatacctccc gcctggagtc tggagtccct      180

tctcgcttct ctggttctgg ttctgggacg gattacactc tgaccatcag cagtctgcaa      240

ccggaagact tcgcaactta ttactgtcag caaggtaata ctctgccgtg gacgttcgga      300

cagggcacca aggtggagat caaaggcggc ggcggaagtg gaggaggagg ctcaggcgga      360

ggagggagcg aggttcagct ggtggagtct ggcggtggcc tggtgcagcc agggggctca      420

ctccgtttgt cctgtgcagc ttctggctac tcctttaccg gctacactat gaactgggtg      480

cgtcaggccc caggtaaggg cctggaatgg gttgcactga ttaatcctac caaaggtgtt      540

agtacctaca accagaagtt caaggaccgt ttcactataa gcgtagataa atccaaaaac      600

acagcctacc tgcaaatgaa cagcctgcgt gctgaggaca ctgccgtcta ttattgtgct      660

agaagcggat actacggcga tagtgactgg tattttgacg tgtggggtca aggaaccctg      720

gtcaccgtct cctcg                                                       735


<210> 28
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Thr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210> 29
<211> 245
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asn 
            20                  25                  30          


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Thr Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
        115                 120                 125             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    130                 135                 140                 


Cys Ala Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Asn Pro 
                165                 170                 175     


Tyr Lys Gly Val Ser Thr Tyr Asn Gln Lys Phe Lys Asp Arg Phe Thr 
            180                 185                 190         


Ile Ser Val Asp Lys Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
        195                 200                 205             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Gly Tyr 
    210                 215                 220                 


Tyr Gly Asp Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Leu 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210> 30
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


