               SEQUENCE LISTING

<110> Universität für Bodenkultur Wien

<120> CYSTEINE ENGINEERED ANTIGEN-BINDING MOLECULES

<130> FS025P

<160> 88

<170> BiSSAP 1.3

<210> 1
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody domain

<400> 1
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Cys Lys 
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110     

<210> 2
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody domain

<400> 2
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      
Ala Cys Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110     

<210> 3
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody domain

<400> 3
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Cys Lys 
                85                  90                  95      
Ala Cys Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
            100                 105                 110     

<210> 4
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 4
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Cys Lys 
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 5
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 5
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      
Ala Cys Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 6
<211> 217
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 6
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Cys Lys 
                85                  90                  95      
Ala Cys Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             
Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         

<210> 7
<211> 15
<212> PRT
<213> Homo sapiens

<400> 7
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  

<210> 8
<211> 106
<212> PRT
<213> Homo sapiens

<400> 8
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
1               5                   10                  15      
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            20                  25                  30          
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        35                  40                  45              
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    50                  55                  60                  
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
65                  70                  75                  80  
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                85                  90                  95      
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105     

<210> 9
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody mutant

<400> 9
Gln Pro Phe Arg Pro Glu Val His Leu Leu Pro Pro Ser Arg Glu Glu 
1               5                   10                  15      
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Ala Arg Gly Phe Tyr 
            20                  25                  30          
Pro Lys Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        35                  40                  45              
Asn Tyr Lys Thr Thr Pro Ser Arg Gln Glu Pro Ser Gln Gly Thr Thr 
    50                  55                  60                  
Thr Phe Ala Val Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
65                  70                  75                  80  
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                85                  90                  95      
His Tyr Thr Gln Lys Thr Ile Ser Leu Ser Pro Gly Lys 
            100                 105                 

<210> 10
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody mutant

<400> 10
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Pro Ser Glu Glu 
1               5                   10                  15      
Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          
Tyr Pro Ser Asp Ile Ala Val Glu Trp Leu Gln Gly Ser Gln Glu Leu 
        35                  40                  45              
Pro Arg Glu Lys Tyr Leu Thr Trp Ala Pro Val Leu Asp Ser Asp Gly 
    50                  55                  60                  
Ser Phe Phe Leu Tyr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp Lys 
65                  70                  75                  80  
Lys Gly Asp Thr Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                85                  90                  95      
His Tyr Thr Gln Lys Ser Leu Asp Arg Ser Pro Gly Lys 
            100                 105                 

<210> 11
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Recognition sequence

<400> 11
Glu Leu Asp Lys Trp Ala 
1               5       

<210> 12
<211> 223
<212> PRT
<213> Homo sapiens

<400> 12
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             

<210> 13
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 13
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Glu Leu Asp Lys Trp Ala Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             

<210> 14
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 14
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Leu Asp Lys Trp Ala Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             

<210> 15
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 15
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Glu Leu Asp Lys Trp Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             

<210> 16
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 16
gtcacatgcg tggtggtgga actcgataag tgggcccctg aggtcaagtt caactgg        57


<210> 17
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 17
ccagttgaac ttgacctcag gggcccactt atcgagttcc accaccacgc atgtgac        57


<210> 18
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 18
caagacaaag ccgcgcgagg aactcgataa gtgggcctac cgtgtggtca gcgtcc         56


<210> 19
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 19
ggacgctgac cacacggtag gcccacttat cgagttcctc gcgcggcttt gtcttg         56


<210> 20
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 20
caagtgcaag gtctccgaac tcgataagtg ggcccccatc gagaaaacca tctcc          55


<210> 21
<211> 55
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
ggagatggtt ttctcgatgg gggcccactt atcgagttcg gagaccttgc acttg          55


<210> 22
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 22
ggagtacaag tgcaaggtct gtaacaaagc cctcccagcc ccc                       43


<210> 23
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 23
gggggctggg agggctttgt tacagacctt gcacttgtac tcc                       43


<210> 24
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 24
gggggctggg agggctttac aggagacctt gcacttgtac tc                        42


<210> 25
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 25
gggggctggg agggctttac aggagacctt gcacttgtac tc                        42


<210> 26
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 26
gtgcaaggtc tccaactgtg ccctcccagc cccc                                 34


<210> 27
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 27
gggggctggg agggcacagt tggagacctt gcac                                 34


<210> 28
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 28
gcaaggtctc caacaaatgc ctcccagccc ccatcg                               36


<210> 29
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 29
cgatgggggc tgggaggcat ttgttggaga ccttgc                               36


<210> 30
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 30
ggtctccaac aaagcctgcc cagcccccat cgagaaaacc                           40


<210> 31
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 31
ggttttctcg atgggggctg ggcaggcttt gttggagacc                           40


<210> 32
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 32
ggtctccaac aaagccctct gcgcccccat cgagaaaacc                           40


<210> 33
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 33
ggttttctcg atgggggcgc agagggcttt gttggagacc                           40


<210> 34
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 34
ggtctccaac aaagccctcc catgccccat cgagaaaacc                           40


<210> 35
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 35
ggttttctcg atggggcatg ggagggcttt gttggagacc                           40


<210> 36
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 36
gagtacaagt gcaaggtgtg taacaaggcc ctgcctgc                             38


<210> 37
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 37
gcaggcaggg ccttgttaca caccttgcac ttgtactc                             38


<210> 38
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 38
gagtacaagt gcaaggtgag ctgtaaagcc ctgcctgccc cc                        42


<210> 39
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 39
gggggcaggc agggctttac agctcacctt gcacttgtac tc                        42


<210> 40
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 40
ggtgagcaac aaggcctgtc ctgcacccat cgagaagacc                           40


<210> 41
<211> 40
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 41
ggtcttctcg atgggtgcag gacaggcctt gttgctcacc                           40


<210> 42
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 42
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Cys Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Phe Phe Thr Tyr Trp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Arg Arg Arg 
            180                 185                 190         
Trp Thr Ala Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             

<210> 43
<211> 223
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc mutant

<400> 43
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      
Cys Lys Val Ser Asn Lys Ala Cys Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             
Pro Ser Arg Asp Glu Phe Phe Thr Tyr Trp Val Ser Leu Thr Cys Leu 
    130                 135                 140                 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Arg Arg Arg 
            180                 185                 190         
Trp Thr Ala Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220             

<210> 44
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 44
Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      
Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              
Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
65                  70                  75                  80  
Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      
Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 45
<211> 1404
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 45
atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt cctatcccag      60

gtgcagctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc     120

tgcacagtct ctggtttctc attaactaac tatggtgtac actgggttcg ccagtctcca     180

ggaaagggtc tggagtggct gggagtgata tggagtggtg gaaacacaga ctataataca     240

cctttcacat ccagactgag catcaacaag gacaattcca agagccaagt tttctttaaa     300

atgaacagtc tgcaatctaa tgacacagcc atatattact gtgccagagc cctcacctac     360

tatgattacg agtttgctta ctggggccaa gggactctgg tcactgtctc tgcagctagc     420

accaagggcc ccagcgtgtt ccctctggcc cccagctcca agagcacctc cggcggcacc     480

gccgccctgg gctgcctggt gaaggattac ttcccagagc ccgtgaccgt gagctggaac     540

agcggcgccc tgaccagcgg cgtgcacacc tttcccgccg tgctgcagtc cagcggcctg     600

tactccctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc     660

tgcaatgtga accacaagcc cagcaatacc aaggtggata agaaggtgga gcccaagagc     720

tgcgacaaga cacacacgtg tcccccatgt cccgcccctg agctgctggg cggcccttcc     780

gtgttcctgt tccctcccaa gccaaaggac accctgatga tctcccggac ccctgaggtg     840

acctgtgtgg tggtggacgt gagccacgag gacccagagg tgaagttcaa ctggtacgtg     900

gacggcgtgg aggtgcacaa cgccaagacc aagcctagag aggagcagta caacagcacc     960

taccgcgtgg tgagcgtgct gaccgtgctg caccaggatt ggctgaatgg caaggagtac    1020

aagtgcaagg tgagcaacaa ggccctgcct gcccccatcg agaagaccat ctccaaggcc    1080

aagggccagc ctcgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc    1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg    1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac    1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag    1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag    1380

agcctctccc tgtctccggg taaa                                           1404


<210> 46
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 46
Met Val Ser Thr Pro Gln Phe Leu Val Phe Leu Leu Phe Trp Ile Pro 
1               5                   10                  15      
Ala Ser Arg Gly Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser 
            20                  25                  30          
Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro 
    50                  55                  60                  
Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn 
                85                  90                  95      
Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn 
            100                 105                 110         
Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 47
<211> 702
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 47
atggtatcca cacctcagtt ccttgtattt ttgcttttct ggattccagc ctccagaggt      60

gacatcttgc tgactcagtc tccagtcatc ctgtctgtga gtccaggaga aagagtcagt     120

ttctcctgca gggccagtca gagtattggc acaaacatac actggtatca gcaaagaaca     180

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg aatcccttcc     240

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct     300

gaagatattg cagattatta ctgtcaacaa aataataact ggccaaccac gttcggtgct     360

gggaccaagc tggagctgaa aagaactgtt gcggcgccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                        702


<210> 48
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 48
caagtgcaag gtgagctgta aggccctgcc tgcc                                 34


<210> 49
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 49
ggcaggcagg gccttacagc tcaccttgca cttg                                 34


<210> 50
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 50
gtgagcaaca aggcctgccc tgcccccatc gagaag                               36


<210> 51
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 51
cttctcgatg ggggcagggc aggccttgtt gctcac                               36


<210> 52
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 52
ggacgtgagc cacgaggact gcgaggtgaa gttcaac                              37


<210> 53
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 53
gttgaacttc acctcgcagt cctcgtggct cacgtcc                              37


<210> 54
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 54
cgccaagacc aagccttgcg aggagcagta caac                                 34


<210> 55
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 55
gttgtactgc tcctcgcaag gcttggtctt ggcg                                 34


<210> 56
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 56
ctcccaagcc aaaggacgtg ctgatgatct cccggac                              37


<210> 57
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 57
gtccgggaga tcatcagcac gtcctttggc ttgggag                              37


<210> 58
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 58
gcttctatcc cagcgatatc gtggtggagt gggagagcaa tgggcagc                  48


<210> 59
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 59
gctgcccatt gctctcccac tccaccacga tatcgctggg atagaagc                  48


<210> 60
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 60
ggtgagctgt aaggcctgtc ctgcccccat cgag                                 34


<210> 61
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 61
ctcgatgggg gcaggacagg ccttacagct cacc                                 34


<210> 62
<211> 466
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 62
Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      
Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          
Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              
Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  
Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
65                  70                  75                  80  
Pro Phe Thr Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      
Val Phe Phe Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Pro Lys Ser 
225                 230                 235                 240 
Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Ala Gln Ser Thr Phe 
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     
Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 
Pro Gly 
465     

<210> 63
<211> 1398
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 63
atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt cctatcccag      60

gtgcagctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc     120

tgcacagtct ctggtttctc attaactaac tatggtgtac actgggttcg ccagtctcca     180

ggaaagggtc tggagtggct gggagtgata tggagtggtg gaaacacaga ctataataca     240

cctttcacat ccagactgag catcaacaag gacaattcca agagccaagt tttctttaaa     300

atgaacagtc tgcaatctaa tgacacagcc atatattact gtgccagagc cctcacctac     360

tatgattacg agtttgctta ctggggccaa gggactctgg tcactgtctc tgcagctagc     420

accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca     480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     540

tcaggcgctc tgaccagcgg cgtgcacacc ttcccagctg tcctacagtc ctcaggactc     600

tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc     660

tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcccaaatct     720

tctgacaaaa ctcacacatg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc     780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg     840

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac     900

ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcaggccca gagcacgttc     960

cgtgtggtca gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag    1020

tgcgctgtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa    1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cacgggagga gatgaccaag    1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag    1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc    1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg    1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc    1380

ctctccctgt ccccgggt                                                  1398


<210> 64
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 64
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      
Ser Leu Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu 
        35                  40                  45              
Thr Asn Tyr Gly Val His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
65                  70                  75                  80  
Pro Phe Thr Ser Arg Val Thr Ile Thr Ser Asp Lys Ser Thr Ser Thr 
                85                  90                  95      
Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 65
<211> 1344
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 65
gaggtccaat tggtgcagtc tggagctgag gtgaagaagc ctggagcttc agtgaaggtg      60

tcctgcaaag cttctggatt ctcattaact aactatggtg tacactggat gcgtcaggct     120

cctgggcagg gtctcgagtg gattggagtg atatggagtg gtggaaacac agactataat     180

acacctttca catccagagt cacaatcact tcagacaaat ccaccagcac agcctacatg     240

gagctcagca gcctgaggtc tgaggacact gcggtctatt actgtgcaag agccctcacc     300

tactatgatt acgagtttgc ttactggggt caaggcaccc tggtcacagt ctcctcagcc     360

tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc     420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg     480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga     540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac     600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa     660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg     720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctctag aacccctgag     780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac gatatccaaa    1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcacg ggaggagatg    1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc    1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg    1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag    1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag    1320

aagagcctct ccctgtcccc gggt                                           1344


<210> 66
<211> 233
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 66
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      
Ser Leu Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              
Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  
Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asn Tyr Asn 
            100                 105                 110         
Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             
Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 
Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 
Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     
Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         
Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             
Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 
Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             

<210> 67
<211> 699
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 67
atgaagcttc ctgttaggct gttggtgctg atgttctgga tccctgctag cttaagcgat      60

atccagatga cccagtctcc gagctccctg tccgcatctg tgggagacag agtcaccatc     120

acttgcaggg ccagtcagag tattggcaca aacatacact ggtatcagca gaagccaggg     180

aaagctccta agcttcttat taagtatgct tctgagtcta tctctggagt cccatcccga     240

ttctccggaa gtggctatgg tacagatttt actctcacaa ttagcagcct gcagcctgaa     300

gatgttgcaa cttactactg tcaacaaaat tataactggc caaccacgtt tggccaaggt     360

accaaggtgg aaataaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct     420

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc     480

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag     540

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg     600

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg     660

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                            699


<210> 68
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 68
caagtgcgct gtctcctgca aaggcctccc agc                                  33


<210> 69
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 69
gctgggaggc ctttgcagga gacagcgcac ttg                                  33


<210> 70
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 70
gtctccaaca aaggctgccc agcccccatc gag                                  33


<210> 71
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 71
ctcgatgggg gctgggcagc ctttgttgga gac                                  33


<210> 72
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 72
gtctcctgca aaggctgccc agcccccatc gag                                  33


<210> 73
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 73
ctcgatgggg gctgggcagc ctttgcagga gac                                  33


<210> 74
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 74
taccccagcg acatcgtggt ggagtgggag agc                                  33


<210> 75
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 75
gctctcccac tccaccacga tgtcgctggg gta                                  33


<210> 76
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 76
gtgagccacg aagactgcga ggtccagttc aac                                  33


<210> 77
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 77
gttgaactgg acctcgcagt cttcgtggct cac                                  33


<210> 78
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 78
gccaagacaa agccatgcga ggagcaggcc cag                                  33


<210> 79
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 79
ctgggcctgc tcctcgcatg gctttgtctt ggc                                  33


<210> 80
<211> 501
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 80
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      
Ser Leu Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Ser Leu 
        35                  40                  45              
Thr Asn Tyr Gly Val His Trp Met Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr 
65                  70                  75                  80  
Pro Phe Thr Ser Arg Val Thr Ile Thr Ser Asp Lys Ser Thr Ser Thr 
                85                  90                  95      
Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
            100                 105                 110         
Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
145                 150                 155                 160 
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
                165                 170                 175     
Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys 
            180                 185                 190         
Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile 
        195                 200                 205             
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe 
    210                 215                 220                 
Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr 
225                 230                 235                 240 
Cys Gln Gln Asn Tyr Asn Trp Pro Thr Thr Phe Gly Gln Gly Thr Lys 
                245                 250                 255     
Val Glu Ile Lys Ser Ser Gly Pro Gly Val Glu Pro Lys Ser Ser Asp 
            260                 265                 270         
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 
Thr Leu Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr 
                405                 410                 415     
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         
Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp 
        435                 440                 445             
Ala Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ile Leu 
    450                 455                 460                 
Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Ser 
465                 470                 475                 480 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Asp 
                485                 490                 495     
Arg Ser Pro Gly Lys 
            500     

<210> 81
<211> 1503
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 81
atgaagcttc ctgttaggct gttggtgctg atgttctgga tccctgctag cttaagcgag      60

gtccaattgg tgcagtctgg agctgaggtg aagaagcctg gagcttcagt gaaggtgtcc     120

tgcaaagctt ctggattctc attaactaac tatggtgtac actggatgcg tcaggctcct     180

gggcagggtc tcgagtggat tggagtgata tggagtggtg gaaacacaga ctataataca     240

cctttcacat ccagagtcac aatcacttca gacaaatcca ccagcacagc ctacatggag     300

ctcagcagcc tgaggtctga ggacactgcg gtctattact gtgcaagagc cctcacctac     360

tatgattacg agtttgctta ctggggtcaa ggcaccctgg tcacagtctc ctcgggaggt     420

ggaggttctg gaggtggcgg atccggaggt ggcggttctg atatccagat gacccagtct     480

ccgagctccc tgtccgcatc tgtgggagac agagtcacca tcacttgcag ggccagtcag     540

agtattggca caaacataca ctggtatcag cagaagccag ggaaagctcc taagcttctt     600

attaagtatg cttctgagtc tatctctgga gtcccatccc gattctccgg aagtggctat     660

ggtacagatt ttactctcac aattagcagc ctgcagcctg aagatgttgc aacttactac     720

tgtcaacaaa attataactg gccaaccacg tttggccaag gtaccaaggt ggaaataaaa     780

tcttccggtc ctggagtgga gcctaaatct tctgacaaaa ctcacacgtg cccaccgtgc     840

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     900

accctcatga tctctagaac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     960

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca    1020

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg    1080

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca    1140

gcccccatcg agaaaacgat atccaaagcc aaagggcagc cccgagaacc acaggtgtac    1200

accctgcccc caccgtcgga ggagctggcc ctgaacgagc tggtgacgct gacctgcctg    1260

gtcaaaggct tctatcccag cgacatcgcc gtggagtggc tgcaggggtc ccaggagctg    1320

ccccgcgaga agtacctgac ttgggcaccc gtgctggact ccgacggctc cttcttcctc    1380

tatagtatac tgcgcgtggc agccgaggac tggaagaagg gggacacctt ctcatgctcc    1440

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctcgaccg ctccccgggt    1500

aaa                                                                  1503


<210> 82
<211> 470
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 82
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val 
            20                  25                  30          
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              
Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  
Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         
Val Tyr Tyr Cys Ala Lys Asp Arg Arg Ile Thr His Thr Tyr Trp Gly 
        115                 120                 125             
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
    130                 135                 140                 
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 
Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Phe Arg Pro Glu Val 
        355                 360                 365             
His Leu Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 
Leu Thr Cys Leu Ala Arg Gly Phe Tyr Pro Lys Asp Ile Ala Val Glu 
385                 390                 395                 400 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Ser 
                405                 410                 415     
Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Lys 
            420                 425                 430         
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Thr Ile 
    450                 455                 460                 
Ser Leu Ser Pro Gly Lys 
465                 470 

<210> 83
<211> 1410
<212> DNA
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 83
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg gtcgaccggc      60

gaagtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     120

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct     180

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac     240

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat     300

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaagatcgg     360

cgtattaccc acacctactg gggccaggga accctggtca ccgtctcctc agctagcacc     420

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg     480

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca     540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac     600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc     660

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt     720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc     780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaacgatatc caaagccaaa    1080

gggcagccct tccggccaga ggtccacctg ctgcccccat cacgggagga gatgaccaag    1140

aaccaggtca gcctgacctg cctggcacgc ggcttctatc ccaaggacat cgccgtggag    1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgccttcccg gcaggagccc    1260

agccagggca ccaccacctt cgctgtgacc tcgaagctca ccgtggacaa gagcagatgg    1320

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg    1380

cagaagacca tctccctgtc cccgggtaaa                                     1410


<210> 84
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Antibody sequence

<400> 84
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Glu Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val 
            20                  25                  30          
Ala Pro Gly Glu Thr Ala Thr Ile Pro Cys Gly Gly Asp Ser Leu Gly 
        35                  40                  45              
Ser Lys Ile Val His Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Leu 
    50                  55                  60                  
Leu Val Val Tyr Asp Asp Ala Ala Arg Pro Ser Gly Ile Pro Glu Arg 
65                  70                  75                  80  
Phe Ser Gly Ser Lys Ser Gly Thr Thr Ala Thr Leu Thr Ile Ser Ser 
                85                  90                  95      
Val Glu Ala Gly Asp Glu Ala Asp Tyr Phe Cys Gln Val Tyr Asp Tyr 
            100                 105                 110         
His Ser Asp Val Glu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
        115                 120                 125             
Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
    130                 135                 140                 
Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
145                 150                 155                 160 
Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
                165                 170                 175     
Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
            180                 185                 190         
Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
        195                 200                 205             
Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
    210                 215                 220                 
Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
225                 230                 

<210> 85
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 85
caagtgcaag gtctcctgta aagccctccc agcc                                 34


<210> 86
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 86
ggctgggagg gctttacagg agaccttgca cttg                                 34


<210> 87
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 87
gtctccaaca aagcctgccc agcccccatc gag                                  33


<210> 88
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 88
ctcgatgggg gctgggcagg ctttgttgga gac                                  33


