                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF
        USE

<130>  57766-519832

<150>  US 62/565,980
<151>  2017-09-29

<150>  US 62/679,142
<151>  2018-06-01

<150>  US 62/720,292
<151>  2018-08-21

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser His Arg Leu Leu Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Thr Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  2
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Ala Ser Leu Arg Leu Phe Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Ala Gly Thr Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Ile Asn Val 
        35                  40                  45              


Ala Val His Val Phe Arg Lys Ala Ala Asp Asp Thr Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ser Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Glu Glu Glu Phe Val Glu Gly Ile Tyr Lys Val Glu Ile Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Ala Leu Gly Ile Ser Pro Phe His Glu His Ala Glu 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly Pro Arg Arg Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Thr Asn 
    130                 135                 140                 


Pro Lys Glu 
145         


<210>  3
<211>  7258
<212>  DNA
<213>  Homo sapiens

<400>  3
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacggtgag tgtttctgtg acatcccatt cctacattta      240

agattcacgc taaatgaagt agaagtgact ccttccagct ttgccaacca gcttttatta      300

ctagggcaag ggtacccagc atctattttt aatataatta attcaaactt caaaaagaat      360

gaagttccac tgagcttact gagctgggac ttgaactctg agcattctac ctcattgctt      420

tggtgcatta ggtttgtaat atctggtacc tctgtttcct cagatagatg atagaaataa      480

agatatgata ttaaggaagc tgttaatact gaattttcag aaaagtatcc ctccataaaa      540

tgtatttggg ggacaaactg caggagatta tattctggcc ctatagttat tcaaaacgta      600

tttattgatt aatctttaaa aggcttagtg aacaatattc tagtcagata tctaattctt      660

aaatcctcta gaagaattaa ctaatactat aaaatgggtc tggatgtagt tctgacatta      720

ttttataaca actggtaaga gggagtgact atagcaacaa ctaaaatgat ctcaggaaaa      780

cctgtttggc cctatgtatg gtacattaca tcttttcagt aattccactc aaatggagac      840

ttttaacaaa gcaactgttc tcaggggacc tattttctcc cttaaaattc attatacaca      900

tccctggttg atagcagtgt gtctggaggc agaaaccatt cttgctttgg aaacaattac      960

gtctgtgtta tactgagtag ggaagctcat taattgtcga cacttacgtt cctgataatg     1020

ggatcagtgt gtaattcttg tttcgctcca gatttctaat accacaaaga ataaatcctt     1080

tcactctgat caattttgtt aacttctcac gtgtcttctc tacacccagg gcaccggtga     1140

atccaagtgt cctctgatgg tcaaagttct agatgctgtc cgaggcagtc ctgccatcaa     1200

tgtggccgtg catgtgttca gaaaggctgc tgatgacacc tgggagccat ttgcctctgg     1260

gtaagttgcc aaagaaccct cccacaggac ttggttttat cttcccgttt gcccctcact     1320

tggtagagag aggctcacat catctgctaa agaatttaca agtagattga aaaacgtagg     1380

cagaggtcaa gtatgccctc tgaaggatgc cctctttttg ttttgcttag ctaggaagtg     1440

accaggaacc tgagcatcat ttaggggcag acagtagaga aaagaaggaa tcagaactcc     1500

tctcctctag ctgtggtttg caaccctttt gggtcacaga acactttatg taggtgatga     1560

aaagtaaaca ttctatgccc agaaaaaatg cacagataca cacacataca aaatcatata     1620

tgtgatttta ggagtttcac agattccctg gtgtccctgg gtaacaccaa agctaagtgt     1680

ccttgtctta gaattttagg aaaaggtata atgtgtatta acccattaac aaaaggaaag     1740

gaattcagaa atattattaa ccaggcatct gtctgtagtt aatatggatc acccaaaacc     1800

caaggctttt gcctaatgaa cactttgggg cacctactgt gtgcaaggct gggggctgtc     1860

aagctcagtt aaaaaaaaaa agatagaaga gatggatcca tgaggcaaag tacagcccca     1920

ggctaatccc acgatcaccc gacttcatgt ccaagagtgg cttctcacct tcattagcca     1980

gttcacaatt ttcatggagt ttttctacct gcactagcaa aaacttcaag gaaaatacat     2040

attaataaat ctaagcaaag tgaccagaag acagagcaat caggagaccc tttgcatcca     2100

gcagaagagg aactgctaag tatttacatc tccacagaga agaatttctg ttgggtttta     2160

attgaacccc aagaaccaca tgattcttca accattattg ggaagatcat tttcttaggt     2220

ctggttttaa ctggcttttt atttgggaat tcatttatgt ttatataaaa tgccaagcat     2280

aacatgaaaa gtggttacag gactattcta agggagagac agaatggaca ccaaaaatat     2340

tccaatgttc ttgtgaatct tttccttgca ccaggacaaa aaaaaaaaga agtgaaaaga     2400

agaaaggagg aggggcataa tcagagtcag taaagacaac tgctattttt atctatcgta     2460

gctgttgcag tcaaatggga agcaatttcc aacattcaac tatggagctg gtacttacat     2520

ggaaatagaa gttgcctagt gtttgttgct ggcaaagagt tatcagagag gttaaatata     2580

taaaagggaa aagagtcaga tacaggttct tcttcctact ttaggttttc cactgtgtgt     2640

gcaaatgata ctccctggtg gtgtgcagat gcctcaaagc tatcctcaca ccacaaggga     2700

gaggagcgag atcctgctgt cctggagaag tgcagagtta gaacagctgt ggccacttgc     2760

atccaatcat caatcttgaa tcacagggac tctttcttaa gtaaacatta tacctggccg     2820

ggcacggtgg ctcacgcctg taatcccagc actttgggat gccaaagtgg gcatatcatc     2880

tgaggtcagg agttcaagac cagcctggcc aacatggcaa aactccgtct ttatgaaaaa     2940

tacaaaaatt agccaggcat ggtggcaggc gcctgtaatc ccagctaatt gggaggctga     3000

ggctggagaa tcccttgaat ctaggaggca gaggttgcag tgagctgaga tcgtgccatt     3060

gcactccagc ctgggtgaca agagtaaaac tctgtctcaa aaaaaaaaaa ttatacctac     3120

attctcttct tatcagagaa aaaaatctac agtgagcttt tcaaaaagtt tttacaaact     3180

ttttgccatt taatttcagt taggagtttt ccctacttct gacttagttg aggggaaatg     3240

ttcataacat gtttataaca tgtttatgtg tgttagttgg tgggggtgta ttactttgcc     3300

atgccatttg tttcctccat gcgtaactta atccagactt tcacacctta taggaaaacc     3360

agtgagtctg gagagctgca tgggctcaca actgaggagg aatttgtaga agggatatac     3420

aaagtggaaa tagacaccaa atcttactgg aaggcacttg gcatctcccc attccatgag     3480

catgcagagg tgagtataca gaccttcgag ggttgttttg gttttggttt ttgcttttgg     3540

cattccagga aatgcacagt tttactcagt gtaccacaga aatgtcctaa ggaaggtgat     3600

gaatgaccaa aggttccctt tcctattata caagaaaaaa ttcacaacac tctgagaagc     3660

aaatttcttt ttgactttga tgaaaatcca cttagtaaca tgacttgaac ttacatgaaa     3720

ctactcatag tctattcatt ccactttata tgaatattga tgtatctgct gttgaaataa     3780

tagtttatga ggcagccctc cagaccccac gtagagtgta tgtaacaaga gatgcaccat     3840

tttatttctc gaaaacccgt aacattcttc attccaaaac acatctggct tctcggaggt     3900

ctggacaagt gattcttggc aacacatacc tatagagaca ataaaatcaa agtaataatg     3960

gcaacacaat agataacatt taccaagcat acaccatgtg gcagacacaa ttataagtgt     4020

tttccatatt taacctactt aatcctcagg aataagccac tgaggtcagt cctattatta     4080

tccccatctt atagatgaag aaaatgaggc accaggaagt caaataactt gtcaaaggtc     4140

acaagactag gaaatacaca agtagaaatg tttacaatta aggcccaggc tgggtttgcc     4200

ctcagttctg ctatgcctcg cattatgccc caggaaactt tttcccttgt gaaagccaag     4260

cttaaaaaaa gaaaagccac atttgtaacg tgctctgttc ccctgcctat ggtgaggatc     4320

ttcaaacagt tatacatgga cccagtcccc ctgccttctc cttaatttct taagtcattt     4380

gaaacagatg gctgtcatgg aaatagaatc cagacatgtt ggtcagagtt aaagatcaac     4440

taattccatc aaaaatagct cggcatgaaa gggaactatt ctctggctta gtcatggatg     4500

agactttcaa ttgctataaa gtggttcctt tattagacaa tgttaccagg gaaacaacag     4560

gggtttgttt gacttctggg gcccacaagt caacaagaga gccccatcta ccaaggagca     4620

tgtccctgac tacccctcag ccagcagcaa gacatggacc ccagtcaggg caggagcagg     4680

gtttcggcgg cgcccagcac aagacattgc ccctagagtc tcagccccta ccctcgagta     4740

atagatctgc ctacctgaga ctgttgtttg cccaagagct gggtctcagc ctgatgggaa     4800

ccatataaaa aggttcactg acatactgcc cacatgttgt tctctttcat tagatcttag     4860

cttccttgtc tgctcttcat tcttgcagta ttcattcaac aaacattaaa aaaaaaaaaa     4920

agcattctat gtgtggaaca ctctgctaga tgctgtggat ttagaaatga aaatacatcc     4980

cgacccttgg aatggaaggg aaaggactga agtaagacag attaagcagg accgtcagcc     5040

cagcttgaag cccagataaa tacggagaac aagagagagc gagtagtgag agatgagtcc     5100

caatgcctca ctttggtgac gggtgcgtgg tgggcttcat gcagcttctt ctgataaatg     5160

cctccttcag aactggtcaa ctctaccttg gccagtgacc caggtggtca tagtagattt     5220

accaagggaa aatggaaact tttattagga gctcttaggc ctcttcactt catggatttt     5280

tttttccttt ttttttgaga tggagttttg ccctgtcacc caggctggaa tgcagtggtg     5340

caatctcagc tcactgcaac ctccgcctcc caggttcaag caattctcct gcctcagcct     5400

cccgagtagc tgggactaca ggtgtgcgcc accacaccag gctaattttt gtattttttg     5460

taaagacagg ttttcaccac gttggccagg ctggtctgaa ctccagacct caggtgattc     5520

acctgtctca gcctcccaaa gtgctgggat tacaggtgtg agccaccgtg cccggctact     5580

tcatggattt ttgattacag attatgcctc ttacaatttt taagaagaat caagtgggct     5640

gaaggtcaat gtcaccataa gacaaaagac atttttatta gttgattcta gggaattggc     5700

cttaagggga gccctttctt cctaagagat tcttaggtga ttctcacttc ctcttgcccc     5760

agtattattt ttgtttttgg tatggctcac tcagatcctt ttttcctcct atccctaagt     5820

aatccgggtt tctttttccc atatttagaa caaaatgtat ttatgcagag tgtgtccaaa     5880

cctcaaccca aggcctgtat acaaaataaa tcaaattaaa cacatcttta ctgtcttcta     5940

cctctttcct gacctcaata tatcccaact tgcctcactc tgagaaccaa ggctgtccca     6000

gcacctgagt cgcagatatt ctactgattt gacagaactg tgtgactatc tggaacagca     6060

ttttgatcca caatttgccc agttacaaag cttaaatgag ctctagtgca tgcatatata     6120

tttcaaaatt ccaccatgat cttccacact ctgtattgta aatagagccc tgtaatgctt     6180

ttacttcgta tttcattgct tgttatacat aaaaatatac ttttcttctt catgttagaa     6240

aatgcaaaga ataggagggt gggggaatct ctgggcttgg agacaggaga cttgccttcc     6300

tactatggtt ccatcagaat gtagactggg acaatacaat aattcaagtc tggtttgctc     6360

atctgtaaat tgggaagaat gtttccagct ccagaatgct aaatctctaa gtctgtggtt     6420

ggcagccact attgcagcag ctcttcaatg actcaatgca gttttgcatt ctccctacct     6480

tttttttcta aaaccaataa aatagataca gcctttaggc tttctgggat ttcccttagt     6540

caagctaggg tcatcctgac tttcggcgtg aatttgcaaa acaagacctg actctgtact     6600

cctgctctaa ggactgtgca tggttccaaa ggcttagctt gccagcatat ttgagctttt     6660

tccttctgtt caaactgttc caaaatataa aagaataaaa ttaattaagt tggcactgga     6720

cttccggtgg tcagtcatgt gtgtcatctg tcacgttttt cgggctctgg tggaaatgga     6780

tctgtctgtc ttctctcata ggtggtattc acagccaacg actccggccc ccgccgctac     6840

accattgccg ccctgctgag cccctactcc tattccacca cggctgtcgt caccaatccc     6900

aaggaatgag ggacttctcc tccagtggac ctgaaggacg agggatggga tttcatgtaa     6960

ccaagagtat tccattttta ctaaagcagt gttttcacct catatgctat gttagaagtc     7020

caggcagaga caataaaaca ttcctgtgaa aggcactttt cattccactt taacttgatt     7080

ttttaaattc ccttattgtc ccttccaaaa aaaagagaat caaaatttta caaagaatca     7140

aaggaattct agaaagtatc tgggcagaac gctaggagag atccaaattt ccattgtctt     7200

gcaagcaaag cacgtattaa atatgatctg cagccattaa aaagacacat tctgtaaa       7258


<210>  4
<211>  938
<212>  DNA
<213>  Homo sapiens

<400>  4
gttgactaag tcaataatca gaatcagcag gtttgcagtc agattggcag ggataagcag       60

cctagctcag gagaagtgag tataaaagcc ccaggctggg agcagccatc acagaagtcc      120

actcattctt ggcaggatgg cttctcatcg tctgctcctc ctctgccttg ctggactggt      180

atttgtgtct gaggctggcc ctacgggcac cggtgaatcc aagtgtcctc tgatggtcaa      240

agttctagat gctgtccgag gcagtcctgc catcaatgtg gccgtgcatg tgttcagaaa      300

ggctgctgat gacacctggg agccatttgc ctctgggaaa accagtgagt ctggagagct      360

gcatgggctc acaactgagg aggaatttgt agaagggata tacaaagtgg aaatagacac      420

caaatcttac tggaaggcac ttggcatctc cccattccat gagcatgcag aggtggtatt      480

cacagccaac gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc      540

ctattccacc acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga      600

cctgaaggac gagggatggg atttcatgta accaagagta ttccattttt actaaagcag      660

tgttttcacc tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga      720

aaggcacttt tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa      780

aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa      840

cgctaggaga gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct      900

gcagccatta aaaagacaca ttctgtaaaa aaaaaaaa                              938


<210>  5
<211>  9077
<212>  DNA
<213>  Mus musculus

<400>  5
ctaatctccc taggcaaggt tcatatttgt gtaggttact tattctcctt ttgttgacta       60

agtcaataat cagaatcagc aggtttggag tcagcttggc agggatcagc agcctgggtt      120

ggaaggaggg ggtataaaag ccccttcacc aggagaagcc gtcacacaga tccacaagct      180

cctgacagga tggcttccct tcgactcttc ctcctttgcc tcgctggact ggtatttgtg      240

tctgaagctg gccccgcggt gagtgatcct gtgagcgatc cagacatggc agttagacct      300

tagataaaga agaagtgcct tcttccagat gtgagaacta gagtactcag actctatatt      360

taccattaga ctccaaagag aagagctgga gtgcctctgg ctcttccttc tattgcttta      420

gcgcattggg tctgtagtgc tcagtctctg gtgtccttag ataataaaga tatgagatta      480

acatagaaat aaagatataa aagggctgga tgtatagttt agtggtccag tgtatgccta      540

gtatgtgaaa agccttctgt tcaacctcta gcaatagaaa aacaagatat attctcggtg      600

gggctgttaa tattgaattc tcataaaatc tttaatatat ttagtatgcc tattatgttg      660

ttatatttta gttctttagc taatcaaaat gcattattga tctttctttg tctttttttg      720

gccaacactc tattccagtc tttgaaaaag tcctttaaaa gagttaatca gtataattaa      780

atgagtcagg aagtatgtga gggttatttt acaaccagag ggaattacta tagcaacagc      840

tgattagaat gatctcaaga aaaagcccat tctgtctttt tgcaccatgc acctttcagt      900

ggctccattc agatggagag gcaaacagag caatggctct cagagggcct attttccctt      960

tgaacattca ttatccatat ccctggtgca cagcagtgca tctgggggca gaaactgttc     1020

ttgctttgga aacaatgctg tctatgtcat actggataaa gaagctcatt aattgtcaac     1080

acttatgtta tcataatggg atcagcatgt acttttggtt ttgttccaga gtctatcacc     1140

ggaaagaaca agccggttta ctctgaccca tttcactgac atttctcttg tctcctctgt     1200

gcccagggtg ctggagaatc caaatgtcct ctgatggtca aagtcctgga tgctgtccga     1260

ggcagccctg ctgtagacgt ggctgtaaaa gtgttcaaaa agacctctga gggatcctgg     1320

gagccctttg cctctgggta agcttgtaga aagcccacca tgggaccggt tccaggttcc     1380

catttgctct tattcgtgtt agattcagac acacacaact taccagctag agggctcaga     1440

gagagggctc aggggcgaag ggcacgtatt gctcttgtaa gagacacagg tttaattcct     1500

agcaccagaa tggcagctca taaccatctg aaactcacag tcttaggaga tctgggtatc     1560

tgacattctc ttctacccac catgtgtgtg gtgcacaaat tcacatgcag gcatcaaatc     1620

ttataaacaa caacaaaaaa ccaacaaacc tggtagcaaa agaagattag aaggttaaac     1680

atatgagccg agagcttttg ttttgttttg ttttgttttg ttttgtttac atttcaaatg     1740

ttatcccctt tctcggtccc cctccccaaa ccctctaccc cattctctcc tccccttctt     1800

ctatgagggt gttccccacc aacccactcc caccttcctg ctctcgaatt cccctatact     1860

gggacatcaa gccttcacag aatcaagggc ctctcctccc attgatgccc gacaatgtca     1920

tcctctgcta cctatgtggc tggagccatg ggtcccttca tgtatcctcc ttggttggtg     1980

gtttagtctc tgggaggtct gggggatctg gttgattgat attattgttc ttcctatgag     2040

attgcaaacc ccttcagctc cttcggtcct ttaactcctc cactggggac cccgagctca     2100

gtccaatggt tggctgtgag catccaccag cagaggcctt tttttttttt tttaacaaag     2160

ctgctttatt atgttgctta gagcatgacc aggaaccaga gcacagtcca agactgaagg     2220

gaggaaaagg gggggagtca ataaccccac tgtttcatag tggtttgcaa cccttttata     2280

tcacagccca ctttaggcaa ataatgaaaa ttatagtctc cagggacaga gaagatggtg     2340

caggaagtga agtgcctgct cagaaaatgg gggcttgaat gtgagttccc agactctgtg     2400

taagatgccc agcatcgaag tgcatgctta taacaccagc ctggaggtag aagcttagaa     2460

acaggggtac cctgaagttg cttgttcacc agtgtccctg aatgggtagg tgcatgtttg     2520

gtgagagacc ctgtctcaaa aatcaaggtg taggataatt gaaaatacct agctttgagc     2580

ttagatcatg caaatgtgta cacacactca cacacaccac acacacaaaa aaatgcagag     2640

acagagagat acagagagac agagagatac agagacagag acagagagaa aaggagaaag     2700

taaaaaacaa ataatttaaa gacccatggc cacaaagagg ctcaaagaca agcacgtata     2760

aaaccataca catgtaattt taggagtttt cagattccct ggtacccgtg ggtgatgcac     2820

aagctttgaa tcccagtctt aaaatcttac gaagaacgtg ttcgtgtgtg ctaatttatt     2880

gatgagagga aaggaattga caaagtgccc ttccggagct tcctgcatta cccagactca     2940

gggttttttt aaatgtacac tcagaacaga gtagctctgt gcaagggtag caaccacgaa     3000

gcttaataag aaacatatcg tgagagatct gcaaggcaaa tctaggggct gaccaatctc     3060

acagtcaccc actagcatgt caacacaact tcccacctgt gctagccact tagcaatttt     3120

gtgttgttct gttttgtttt tgtttttaac aaagcaattt caaagagatt tctaattcat     3180

ctaaacaaac aaaccaaaag gaaaacagca aagacgccct gagcacttag cagagcagct     3240

atgcagttat gactcctggg tggagacttt atatcaggct tcaactgaat acctagaacc     3300

tactagtgct cttcatcaat ccttgggaag gtcattttct tttggtgctg ttttgagttt     3360

ctatttgtta atgtcttcat aattatacac gtgttgagca cagcatgcaa agtgattagg     3420

ggaatctagt tggagtggaa tggataccca aatattcaga ctttcttgtg actcttcttt     3480

cttgtaccca catcaaaaaa aaaaaaaatg gagatgagac atggtcagag tcactaaaac     3540

cagctgctac ttttaattac gtggggagca gtttctaaca ttgccattat tgaactgatg     3600

ctgcctgggt ggaaatggaa atcacttagt atttcttgtt ggcaaagaat tactgaatgg     3660

attaaatttc caaagggaga agtcagttac aagtcttttc tttgtttatt aggctttctg     3720

ctatgataaa ttacactact tccagaagtt acccttaggc catgggacac tggactatca     3780

ctctgctgtc acaagagatt acagagttag tcaaggcagc ttgtgacacc ttcagggact     3840

gtcataaact tccagcaagt cattaatcct gaatgcaata ctgtgtgtgt gtgtctatgt     3900

gtgtttgtat gtctgtgtgt gtcttatgtc tgtgtctctg tgtgtgtgtg tgtttgtgtg     3960

tgtgtgtgta tgtatgcctg tgtgtgtctt atgtctgtgt ttgtgtgtct gtgtgtgtct     4020

tatgtctgtg tttgtatgtc tgtgtgtgtc tgtgtgtgtc ttatgtctgt gtctctgtgt     4080

gtgtgtgtgt gtatgtatgt atgtatgtat gtatgtgtat gtgtttgcat ctctctgtgt     4140

gtctgcgctt atatatttgt gtatgtgttt atgtgttcgc ctttgtgcgt tgttggggat     4200

tgaatccagg ggaatacaaa tgttaagaaa gaacgttacc actaagcttc acctgtaggc     4260

cttaaagctt ttctttcttt taaaaattgt aattaattca ttttcagtca ggatctccac     4320

acctcgtccc tgctgctcta gaactcacta tttaaacaca atcgccctca aacctgcagc     4380

aaccctcccg cctctaccct gcgagcacta gaataataac aggtgacccc acacgcctag     4440

attaagacct ttaaggtaaa cattttacta tattttagtc tcataagaca agatgctaca     4500

ataaagctgt acataaagtt ccctcgaatt tcttgctatt ttaactcaaa cataaggatt     4560

tcctcctttt tgattcaggt aacagaaaaa atacacaggt acatacatgt acacacatga     4620

acacacacgc atcacaacca catatgcgca cgcttgtgtg atctatcatt taccatgcca     4680

ctgaactctt ctttccccat aaattcctct ggacttgtgt gccctccagg aagaccgcgg     4740

agtctggaga gctgcacggg ctcaccacag atgagaagtt tgtagaagga gtgtacagag     4800

tagaactgga caccaaatcg tactggaaga cacttggcat ttccccgttc catgaattcg     4860

cggatgtaag tggacacacc aagttgtttg gattttgttt ttagtctcag gaaattccct     4920

tcgctcttgc tgtacgatgg gcatgagtgg aaagtagatt ccacagccag aatccacagt     4980

gctgggaaag caagccttct gaatttttct aaaactcatt tagcaacatg gcctgaacct     5040

gttcacactg cttatggtca gctaactata tttatgtaaa tattcatttc tctgttgagg     5100

aaatgttagt atttgctttt gaggcaacct ccagatacca tggagggcat gtcatagtca     5160

aagagagggc tccctatggt atttctctaa attctggcat ttcctttatt ccaaagcaca     5220

tctagtgtcc ccagaagttt gggtagacaa ttcttggcaa cacagagaat tacaacatgt     5280

tcaaaaccca acagcttaat atctaaatca tcaagcaaac atcacatggc aaagggattt     5340

ctgaatcaaa actgtttcat ccttatgatc aacctatgga ggtctagcct cgacttacac     5400

ccattttacc aataagctaa gagaagctaa gttcctcatc aaggacacaa ggctagcatg     5460

tgtgagcaag tgacagagtt gccctctatg ttggttagtg tgccttagcc agtgtctcag     5520

taagaaatgg agctaaatca aaacccaagg ccaacagcca aaggcacatg agtaaccttt     5580

gcttggcact gggctcagtt tccctggctc ctctcagtcc tcagttcaca gaggcagctg     5640

tcatgcaaat agaatccaag cttgttggtc agacctggag ataacaaatt ccatcaaaaa     5700

tagctcctca tgtgacctag tttgctgtct gttgctatga tacacaccat gaccgaaaag     5760

caaccctggg gagagaaggg tttatttcat cttacagctt acagttcacc atggaggaaa     5820

gccaggtggg aacctggaag tggaaattga agcagagacc agaaaggaat gctgtttact     5880

ggctggctta gctccttttc ttatacagct taggtctatg tgcccagggg atggtactgc     5940

cgagcatagg ctgagcccgc ctacatcaac cattagtcaa aaaaaggtcc atagacttgc     6000

ctacaggcca atctcatgga ggcaataccc cagtggaggg tccctcttcg caggttactc     6060

tagtttgtgt caagttgaca aaacctaacc acaaagcaca aacagggtct gcccttgtgg     6120

cttagccatg gatgacactc tcagatgatg gtgttaccag acaaaccaga ggggctcacc     6180

aagagtctgc cacctaccaa ggtagtactc tactcctcac tgggcaccaa cacccatatt     6240

agctgggcca gtacaggacc cttgctgttt cctgcatgaa ttgtccatag accctgggtc     6300

tcagcctgcc gggagtacct gtaagtagtc gcctcaaaca cattattcct gttggaagac     6360

ttgtctgatt ctcttttaga actcaatcaa caaacgtttt tattttgttt tggctttttg     6420

gagacaagat ctctcatagg ccagcctgac ttgaatgtag ctgaggatga cctgtgctgc     6480

taatcttctc gcctcttcct cccaagtggt aggataatag gcataagaca ccacagcagt     6540

tttactccat accagggctc tgaacccaga ctttaaacac tctatcaact gattcacatt     6600

cccaccccat cattcaacaa acatttgaaa aataaaaccc ttctgccttg agcactctgc     6660

taaatacagc ctttgagtgc ggagtatttc ctcacaacca gggtccaaga tgaccccatc     6720

atacatacca cggaaaatta ggagatgttt ttaggtctct ttgcttgggg taatttttat     6780

gtgtgtgtgt acacagccct gtgcgtgtgt gtgtgtgtgt gtgtgtgtgt gtacaggcac     6840

acacgtgtat gcatgtagag gctacataaa aaccttaggt gtcattctca ggcactctgt     6900

tcaccccttc acacagcccg aacacacaaa atttgaggca ttagcctgga gctcaccagt     6960

taggctagac tgacttgcca gcagacccca ggctgtctcc atctccccag ctctgggatt     7020

acaaactcta tcataccaga catttttata catattctga gcataaaatt catgtcttca     7080

ggctaacaag tcaagagctt aaatgactga gctctcttac gtggtggatt ttttttaaaa     7140

ctacataata tctttttttt ttttttcact tctggggaag aaacaaatga gcctgagtga     7200

caatgcgaca gaaaagaaat tttgaggagt gtgtgtgtct gtgtgtgtgg tggcacatgc     7260

ctctcatcta atgctagagg ctacagtaga atgctcctga attagtggcc agccaaggcc     7320

aagggctagg gttgtaactc agtggcagag ggcttgccta gcattcgcag gatttgatcc     7380

atagcgctat aaataataat aaataaatac aacagtctaa gatgattctc cctttcattt     7440

atctggatgt tatttttgtg ttagttttac tctgtcatcc aatcattgtt tgccctatat     7500

ttggacattt aaaaaaaatc tttattccaa gtgtgttcaa agctgtatcc aaaacctgtc     7560

caccaaatga gtccaatgac atacatcttc tatattacca tctgttccag atttggctga     7620

ctcccggcac ctgggctgtt gctgcaccca tgtctcagat agtctagtga tttgagaagt     7680

gactagtaat tgcaaaatcc agactttgtc cagaaacttc tatgagctcc aaaactttca     7740

tttacatttc tgccagccac aaaccgcttg tgttgtggag agaaccctgt gatgtcttcc     7800

cacagcatct cagccttgtt tcttccctta aaatattcat cttttcacat tagaacatgc     7860

aaagggacag tgggagcgaa acccctggac tgggacgcac gaagccttcc tttctggtca     7920

ggctctcact gtagaaactt aggccggttt cagcatgcag tctgctggag aatggctcct     7980

gccaacattc caggtctgga agtttgtagt ggagttgttg ataaccactg ttcgccacag     8040

gtcttttgtt tgtgggtgtc agtgtttcta ctctcctgac ttttatctga acccaagaaa     8100

gggaacaata gccttcaagc tctctgtgac tctgatctga ccagggccac ccacactgca     8160

gaaggaaact tgcaaagaga gacctgcaat tctctaagag ctccacacag ctccaaagac     8220

ttaggcagca tattttaatc taattattcg tcccccaacc ccaccccaga ggacagttag     8280

acaataaaag gaagattacc agcttagcat cctgtgaaca ctttgtctgc agctcctacc     8340

tctgggctct gttagaacta gctgtctctc ctctctccta ggtggttttc acagccaacg     8400

actctggcca tcgccactac accatcgcag ccctgctcag cccatactcc tacagcacca     8460

cggctgtcgt cagcaacccc cagaattgag agactcagcc caggaggacc aggatcttgc     8520

caaagcagta gcatcccatt tgtaccaaaa cagtgttctt gctctataaa ccgtgttagc     8580

agctcaggaa gatgccgtga agcattctta ttaaaccacc tgctatttca ttcaaactgt     8640

gtttcttttt tatttcctca tttttctccc ctgctcctaa aacccaaaat cttctaaaga     8700

attctagaag gtatgcgatc aaacttttta aagaaagaaa atactttttg actcatggtt     8760

taaaggcatc ctttccatct tggggaggtc atgggtgctc ctggcaactt gcttgaggaa     8820

gataggtcag aaagcagagt ggaccaaccg ttcaatgttt tacaagcaaa acatacacta     8880

agcatggtct gtagctatta aaagcacaca atctgaaggg ctgtagatgc acagtagtgt     8940

tttcccagag catgttcaaa agccctgggt tcaatcacaa tactgaaaag taggccaaaa     9000

aacattctga aaatgaaata tttgggtttt tttttataac ctttagtgac taaataaaga     9060

caaatctaag agactaa                                                    9077


<210>  6
<211>  147
<212>  PRT
<213>  Mus musculus

<400>  6

Met Ala Ser Leu Arg Leu Phe Leu Leu Cys Leu Ala Gly Leu Val Phe 
1               5                   10                  15      


Val Ser Glu Ala Gly Pro Ala Gly Ala Gly Glu Ser Lys Cys Pro Leu 
            20                  25                  30          


Met Val Lys Val Leu Asp Ala Val Arg Gly Ser Pro Ala Val Asp Val 
        35                  40                  45              


Ala Val Lys Val Phe Lys Lys Thr Ser Glu Gly Ser Trp Glu Pro Phe 
    50                  55                  60                  


Ala Ser Gly Lys Thr Ala Glu Ser Gly Glu Leu His Gly Leu Thr Thr 
65                  70                  75                  80  


Asp Glu Lys Phe Val Glu Gly Val Tyr Arg Val Glu Leu Asp Thr Lys 
                85                  90                  95      


Ser Tyr Trp Lys Thr Leu Gly Ile Ser Pro Phe His Glu Phe Ala Asp 
            100                 105                 110         


Val Val Phe Thr Ala Asn Asp Ser Gly His Arg His Tyr Thr Ile Ala 
        115                 120                 125             


Ala Leu Leu Ser Pro Tyr Ser Tyr Ser Thr Thr Ala Val Val Ser Asn 
    130                 135                 140                 


Pro Gln Asn 
145         


<210>  7
<211>  1237
<212>  DNA
<213>  Mus musculus

<400>  7
ctaatctccc taggcaaggt tcatatttgt gtaggttact tattctcctt ttgttgacta       60

agtcaataat cagaatcagc aggtttggag tcagcttggc agggatcagc agcctgggtt      120

ggaaggaggg ggtataaaag ccccttcacc aggagaagcc gtcacacaga tccacaagct      180

cctgacagga tggcttccct tcgactcttc ctcctttgcc tcgctggact ggtatttgtg      240

tctgaagctg gccccgcggg tgctggagaa tccaaatgtc ctctgatggt caaagtcctg      300

gatgctgtcc gaggcagccc tgctgtagac gtggctgtaa aagtgttcaa aaagacctct      360

gagggatcct gggagccctt tgcctctggg aagaccgcgg agtctggaga gctgcacggg      420

ctcaccacag atgagaagtt tgtagaagga gtgtacagag tagaactgga caccaaatcg      480

tactggaaga cacttggcat ttccccgttc catgaattcg cggatgtggt tttcacagcc      540

aacgactctg gccatcgcca ctacaccatc gcagccctgc tcagcccata ctcctacagc      600

accacggctg tcgtcagcaa cccccagaat tgagagactc agcccaggag gaccaggatc      660

ttgccaaagc agtagcatcc catttgtacc aaaacagtgt tcttgctcta taaaccgtgt      720

tagcagctca ggaagatgcc gtgaagcatt cttattaaac cacctgctat ttcattcaaa      780

ctgtgtttct tttttatttc ctcatttttc tcccctgctc ctaaaaccca aaatcttcta      840

aagaattcta gaaggtatgc gatcaaactt tttaaagaaa gaaaatactt tttgactcat      900

ggtttaaagg catcctttcc atcttgggga ggtcatgggt gctcctggca acttgcttga      960

ggaagatagg tcagaaagca gagtggacca accgttcaat gttttacaag caaaacatac     1020

actaagcatg gtctgtagct attaaaagca cacaatctga agggctgtag atgcacagta     1080

gtgttttccc agagcatgtt caaaagccct gggttcaatc acaatactga aaagtaggcc     1140

aaaaaacatt ctgaaaatga aatatttggg ttttttttta taacctttag tgactaaata     1200

aagacaaatc taagagacta aaaaaaaaaa aaaaaaa                              1237


<210>  8
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
guuggaacca uucaaaacag cauagcaagu uaaaauaagg cuaguccguu aucaacuuga       60

aaaaguggca ccgagucggu gc                                                82


<210>  9
<211>  76
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugc                                                       76


<210>  10
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
guuuaagagc uaugcuggaa acagcauagc aaguuuaaau aaggcuaguc cguuaucaac       60

uugaaaaagu ggcaccgagu cggugc                                            86


<210>  11
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (2)..(21)
<223>  n = A, T, C, or G

<400>  11
gnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  n = A, T, C, or G

<400>  12
nnnnnnnnnn nnnnnnnnnn ngg                                               23


<210>  13
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(23)
<223>  n = A, T, C, or G

<400>  13
ggnnnnnnnn nnnnnnnnnn nnngg                                             25


<210>  14
<211>  12208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (98)..(7298)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (7299)..(12108)
<223>  SDC Neo Cassette

<220>
<221>  misc_feature
<222>  (12109)..(12208)
<223>  Mouse Sequence

<400>  14
agcttggcag ggatcagcag cctgggttgg aaggaggggg tataaaagcc ccttcaccag       60

gagaagccgt cacacagatc cacaagctcc tgacaggatg gcttctcatc gtctgctcct      120

cctctgcctt gctggactgg tatttgtgtc tgaggctggc cctacggtga gtgtttctgt      180

gacatcccat tcctacattt aagattcacg ctaaatgaag tagaagtgac tccttccagc      240

tttgccaacc agcttttatt actagggcaa gggtacccag catctatttt taatataatt      300

aattcaaact tcaaaaagaa tgaagttcca ctgagcttac tgagctggga cttgaactct      360

gagcattcta cctcattgct ttggtgcatt aggtttgtaa tatctggtac ctctgtttcc      420

tcagatagat gatagaaata aagatatgat attaaggaag ctgttaatac tgaattttca      480

gaaaagtatc cctccataaa atgtatttgg gggacaaact gcaggagatt atattctggc      540

cctatagtta ttcaaaacgt atttattgat taatctttaa aaggcttagt gaacaatatt      600

ctagtcagat atctaattct taaatcctct agaagaatta actaatacta taaaatgggt      660

ctggatgtag ttctgacatt attttataac aactggtaag agggagtgac tatagcaaca      720

actaaaatga tctcaggaaa acctgtttgg ccctatgtat ggtacattac atcttttcag      780

taattccact caaatggaga cttttaacaa agcaactgtt ctcaggggac ctattttctc      840

ccttaaaatt cattatacac atccctggtt gatagcagtg tgtctggagg cagaaaccat      900

tcttgctttg gaaacaatta cgtctgtgtt atactgagta gggaagctca ttaattgtcg      960

acacttacgt tcctgataat gggatcagtg tgtaattctt gtttcgctcc agatttctaa     1020

taccacaaag aataaatcct ttcactctga tcaattttgt taacttctca cgtgtcttct     1080

ctacacccag ggcaccggtg aatccaagtg tcctctgatg gtcaaagttc tagatgctgt     1140

ccgaggcagt cctgccatca atgtggccgt gcatgtgttc agaaaggctg ctgatgacac     1200

ctgggagcca tttgcctctg ggtaagttgc caaagaaccc tcccacagga cttggtttta     1260

tcttcccgtt tgcccctcac ttggtagaga gaggctcaca tcatctgcta aagaatttac     1320

aagtagattg aaaaacgtag gcagaggtca agtatgccct ctgaaggatg ccctcttttt     1380

gttttgctta gctaggaagt gaccaggaac ctgagcatca tttaggggca gacagtagag     1440

aaaagaagga atcagaactc ctctcctcta gctgtggttt gcaacccttt tgggtcacag     1500

aacactttat gtaggtgatg aaaagtaaac attctatgcc cagaaaaaat gcacagatac     1560

acacacatac aaaatcatat atgtgatttt aggagtttca cagattccct ggtgtccctg     1620

ggtaacacca aagctaagtg tccttgtctt agaattttag gaaaaggtat aatgtgtatt     1680

aacccattaa caaaaggaaa ggaattcaga aatattatta accaggcatc tgtctgtagt     1740

taatatggat cacccaaaac ccaaggcttt tgcctaatga acactttggg gcacctactg     1800

tgtgcaaggc tgggggctgt caagctcagt taaaaaaaaa aagatagaag agatggatcc     1860

atgaggcaaa gtacagcccc aggctaatcc cacgatcacc cgacttcatg tccaagagtg     1920

gcttctcacc ttcattagcc agttcacaat tttcatggag tttttctacc tgcactagca     1980

aaaacttcaa ggaaaataca tattaataaa tctaagcaaa gtgaccagaa gacagagcaa     2040

tcaggagacc ctttgcatcc agcagaagag gaactgctaa gtatttacat ctccacagag     2100

aagaatttct gttgggtttt aattgaaccc caagaaccac atgattcttc aaccattatt     2160

gggaagatca ttttcttagg tctggtttta actggctttt tatttgggaa ttcatttatg     2220

tttatataaa atgccaagca taacatgaaa agtggttaca ggactattct aagggagaga     2280

cagaatggac accaaaaata ttccaatgtt cttgtgaatc ttttccttgc accaggacaa     2340

aaaaaaaaag aagtgaaaag aagaaaggag gaggggcata atcagagtca gtaaagacaa     2400

ctgctatttt tatctatcgt agctgttgca gtcaaatggg aagcaatttc caacattcaa     2460

ctatggagct ggtacttaca tggaaataga agttgcctag tgtttgttgc tggcaaagag     2520

ttatcagaga ggttaaatat ataaaaggga aaagagtcag atacaggttc ttcttcctac     2580

tttaggtttt ccactgtgtg tgcaaatgat actccctggt ggtgtgcaga tgcctcaaag     2640

ctatcctcac accacaaggg agaggagcga gatcctgctg tcctggagaa gtgcagagtt     2700

agaacagctg tggccacttg catccaatca tcaatcttga atcacaggga ctctttctta     2760

agtaaacatt atacctggcc gggcacggtg gctcacgcct gtaatcccag cactttggga     2820

tgccaaagtg ggcatatcat ctgaggtcag gagttcaaga ccagcctggc caacatggca     2880

aaactccgtc tttatgaaaa atacaaaaat tagccaggca tggtggcagg cgcctgtaat     2940

cccagctaat tgggaggctg aggctggaga atcccttgaa tctaggaggc agaggttgca     3000

gtgagctgag atcgtgccat tgcactccag cctgggtgac aagagtaaaa ctctgtctca     3060

aaaaaaaaaa attataccta cattctcttc ttatcagaga aaaaaatcta cagtgagctt     3120

ttcaaaaagt ttttacaaac tttttgccat ttaatttcag ttaggagttt tccctacttc     3180

tgacttagtt gaggggaaat gttcataaca tgtttataac atgtttatgt gtgttagttg     3240

gtgggggtgt attactttgc catgccattt gtttcctcca tgcgtaactt aatccagact     3300

ttcacacctt ataggaaaac cagtgagtct ggagagctgc atgggctcac aactgaggag     3360

gaatttgtag aagggatata caaagtggaa atagacacca aatcttactg gaaggcactt     3420

ggcatctccc cattccatga gcatgcagag gtgagtatac agaccttcga gggttgtttt     3480

ggttttggtt tttgcttttg gcattccagg aaatgcacag ttttactcag tgtaccacag     3540

aaatgtccta aggaaggtga tgaatgacca aaggttccct ttcctattat acaagaaaaa     3600

attcacaaca ctctgagaag caaatttctt tttgactttg atgaaaatcc acttagtaac     3660

atgacttgaa cttacatgaa actactcata gtctattcat tccactttat atgaatattg     3720

atgtatctgc tgttgaaata atagtttatg aggcagccct ccagacccca cgtagagtgt     3780

atgtaacaag agatgcacca ttttatttct cgaaaacccg taacattctt cattccaaaa     3840

cacatctggc ttctcggagg tctggacaag tgattcttgg caacacatac ctatagagac     3900

aataaaatca aagtaataat ggcaacacaa tagataacat ttaccaagca tacaccatgt     3960

ggcagacaca attataagtg ttttccatat ttaacctact taatcctcag gaataagcca     4020

ctgaggtcag tcctattatt atccccatct tatagatgaa gaaaatgagg caccaggaag     4080

tcaaataact tgtcaaaggt cacaagacta ggaaatacac aagtagaaat gtttacaatt     4140

aaggcccagg ctgggtttgc cctcagttct gctatgcctc gcattatgcc ccaggaaact     4200

ttttcccttg tgaaagccaa gcttaaaaaa agaaaagcca catttgtaac gtgctctgtt     4260

cccctgccta tggtgaggat cttcaaacag ttatacatgg acccagtccc cctgccttct     4320

ccttaatttc ttaagtcatt tgaaacagat ggctgtcatg gaaatagaat ccagacatgt     4380

tggtcagagt taaagatcaa ctaattccat caaaaatagc tcggcatgaa agggaactat     4440

tctctggctt agtcatggat gagactttca attgctataa agtggttcct ttattagaca     4500

atgttaccag ggaaacaaca ggggtttgtt tgacttctgg ggcccacaag tcaacaagag     4560

agccccatct accaaggagc atgtccctga ctacccctca gccagcagca agacatggac     4620

cccagtcagg gcaggagcag ggtttcggcg gcgcccagca caagacattg cccctagagt     4680

ctcagcccct accctcgagt aatagatctg cctacctgag actgttgttt gcccaagagc     4740

tgggtctcag cctgatggga accatataaa aaggttcact gacatactgc ccacatgttg     4800

ttctctttca ttagatctta gcttccttgt ctgctcttca ttcttgcagt attcattcaa     4860

caaacattaa aaaaaaaaaa aagcattcta tgtgtggaac actctgctag atgctgtgga     4920

tttagaaatg aaaatacatc ccgacccttg gaatggaagg gaaaggactg aagtaagaca     4980

gattaagcag gaccgtcagc ccagcttgaa gcccagataa atacggagaa caagagagag     5040

cgagtagtga gagatgagtc ccaatgcctc actttggtga cgggtgcgtg gtgggcttca     5100

tgcagcttct tctgataaat gcctccttca gaactggtca actctacctt ggccagtgac     5160

ccaggtggtc atagtagatt taccaaggga aaatggaaac ttttattagg agctcttagg     5220

cctcttcact tcatggattt ttttttcctt tttttttgag atggagtttt gccctgtcac     5280

ccaggctgga atgcagtggt gcaatctcag ctcactgcaa cctccgcctc ccaggttcaa     5340

gcaattctcc tgcctcagcc tcccgagtag ctgggactac aggtgtgcgc caccacacca     5400

ggctaatttt tgtatttttt gtaaagacag gttttcacca cgttggccag gctggtctga     5460

actccagacc tcaggtgatt cacctgtctc agcctcccaa agtgctggga ttacaggtgt     5520

gagccaccgt gcccggctac ttcatggatt tttgattaca gattatgcct cttacaattt     5580

ttaagaagaa tcaagtgggc tgaaggtcaa tgtcaccata agacaaaaga catttttatt     5640

agttgattct agggaattgg ccttaagggg agccctttct tcctaagaga ttcttaggtg     5700

attctcactt cctcttgccc cagtattatt tttgtttttg gtatggctca ctcagatcct     5760

tttttcctcc tatccctaag taatccgggt ttctttttcc catatttaga acaaaatgta     5820

tttatgcaga gtgtgtccaa acctcaaccc aaggcctgta tacaaaataa atcaaattaa     5880

acacatcttt actgtcttct acctctttcc tgacctcaat atatcccaac ttgcctcact     5940

ctgagaacca aggctgtccc agcacctgag tcgcagatat tctactgatt tgacagaact     6000

gtgtgactat ctggaacagc attttgatcc acaatttgcc cagttacaaa gcttaaatga     6060

gctctagtgc atgcatatat atttcaaaat tccaccatga tcttccacac tctgtattgt     6120

aaatagagcc ctgtaatgct tttacttcgt atttcattgc ttgttataca taaaaatata     6180

cttttcttct tcatgttaga aaatgcaaag aataggaggg tgggggaatc tctgggcttg     6240

gagacaggag acttgccttc ctactatggt tccatcagaa tgtagactgg gacaatacaa     6300

taattcaagt ctggtttgct catctgtaaa ttgggaagaa tgtttccagc tccagaatgc     6360

taaatctcta agtctgtggt tggcagccac tattgcagca gctcttcaat gactcaatgc     6420

agttttgcat tctccctacc ttttttttct aaaaccaata aaatagatac agcctttagg     6480

ctttctggga tttcccttag tcaagctagg gtcatcctga ctttcggcgt gaatttgcaa     6540

aacaagacct gactctgtac tcctgctcta aggactgtgc atggttccaa aggcttagct     6600

tgccagcata tttgagcttt ttccttctgt tcaaactgtt ccaaaatata aaagaataaa     6660

attaattaag ttggcactgg acttccggtg gtcagtcatg tgtgtcatct gtcacgtttt     6720

tcgggctctg gtggaaatgg atctgtctgt cttctctcat aggtggtatt cacagccaac     6780

gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc ctattccacc     6840

acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga cctgaaggac     6900

gagggatggg atttcatgta accaagagta ttccattttt actaaagcag tgttttcacc     6960

tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga aaggcacttt     7020

tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa aaaaagagaa     7080

tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa cgctaggaga     7140

gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct gcagccatta     7200

aaaagacaca ttctgtaaat gagagagcct tattttcctg taaccttcag caaatagcaa     7260

aagacacatt ccaagggccc acttctttac tgtgggcact cgagataact tcgtataatg     7320

tatgctatac gaagttatat gcatgccagt agcagcaccc acgtccacct tctgtctagt     7380

aatgtccaac acctccctca gtccaaacac tgctctgcat ccatgtggct cccatttata     7440

cctgaagcac ttgatggggc ctcaatgttt tactagagcc cacccccctg caactctgag     7500

accctctgga tttgtctgtc agtgcctcac tggggcgttg gataatttct taaaaggtca     7560

agttccctca gcagcattct ctgagcagtc tgaagatgtg tgcttttcac agttcaaatc     7620

catgtggctg tttcacccac ctgcctggcc ttgggttatc tatcaggacc tagcctagaa     7680

gcaggtgtgt ggcacttaac acctaagctg agtgactaac tgaacactca agtggatgcc     7740

atctttgtca cttcttgact gtgacacaag caactcctga tgccaaagcc ctgcccaccc     7800

ctctcatgcc catatttgga catggtacag gtcctcactg gccatggtct gtgaggtcct     7860

ggtcctcttt gacttcataa ttcctagggg ccactagtat ctataagagg aagagggtgc     7920

tggctcccag gccacagccc acaaaattcc acctgctcac aggttggctg gctcgaccca     7980

ggtggtgtcc cctgctctga gccagctccc ggccaagcca gcaccatggg aacccccaag     8040

aagaagagga aggtgcgtac cgatttaaat tccaatttac tgaccgtaca ccaaaatttg     8100

cctgcattac cggtcgatgc aacgagtgat gaggttcgca agaacctgat ggacatgttc     8160

agggatcgcc aggcgttttc tgagcatacc tggaaaatgc ttctgtccgt ttgccggtcg     8220

tgggcggcat ggtgcaagtt gaataaccgg aaatggtttc ccgcagaacc tgaagatgtt     8280

cgcgattatc ttctatatct tcaggcgcgc ggtctggcag taaaaactat ccagcaacat     8340

ttgggccagc taaacatgct tcatcgtcgg tccgggctgc cacgaccaag tgacagcaat     8400

gctgtttcac tggttatgcg gcggatccga aaagaaaacg ttgatgccgg tgaacgtgca     8460

aaacaggtaa atataaaatt tttaagtgta taatgatgtt aaactactga ttctaattgt     8520

ttgtgtattt taggctctag cgttcgaacg cactgatttc gaccaggttc gttcactcat     8580

ggaaaatagc gatcgctgcc aggatatacg taatctggca tttctgggga ttgcttataa     8640

caccctgtta cgtatagccg aaattgccag gatcagggtt aaagatatct cacgtactga     8700

cggtgggaga atgttaatcc atattggcag aacgaaaacg ctggttagca ccgcaggtgt     8760

agagaaggca cttagcctgg gggtaactaa actggtcgag cgatggattt ccgtctctgg     8820

tgtagctgat gatccgaata actacctgtt ttgccgggtc agaaaaaatg gtgttgccgc     8880

gccatctgcc accagccagc tatcaactcg cgccctggaa gggatttttg aagcaactca     8940

tcgattgatt tacggcgcta aggatgactc tggtcagaga tacctggcct ggtctggaca     9000

cagtgcccgt gtcggagccg cgcgagatat ggcccgcgct ggagtttcaa taccggagat     9060

catgcaagct ggtggctgga ccaatgtaaa tattgtcatg aactatatcc gtaacctgga     9120

tagtgaaaca ggggcaatgg tgcgcctgct ggaagatggc gattaggcgg ccggccgcta     9180

atcagccata ccacatttgt agaggtttta cttgctttaa aaaacctccc acacctcccc     9240

ctgaacctga aacataaaat gaatgcaatt gttgttgtta acttgtttat tgcagcttat     9300

aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg     9360

cattctagtt gtggtttgtc caaactcatc aatgtatctt atcatgtctg gatcccccgg     9420

ctagagttta aacactagaa ctagtggatc ccccgggatc atggcctccg cgccgggttt     9480

tggcgcctcc cgcgggcgcc cccctcctca cggcgagcgc tgccacgtca gacgaagggc     9540

gcagcgagcg tcctgatcct tccgcccgga cgctcaggac agcggcccgc tgctcataag     9600

actcggcctt agaaccccag tatcagcaga aggacatttt aggacgggac ttgggtgact     9660

ctagggcact ggttttcttt ccagagagcg gaacaggcga ggaaaagtag tcccttctcg     9720

gcgattctgc ggagggatct ccgtggggcg gtgaacgccg atgattatat aaggacgcgc     9780

cgggtgtggc acagctagtt ccgtcgcagc cgggatttgg gtcgcggttc ttgtttgtgg     9840

atcgctgtga tcgtcacttg gtgagtagcg ggctgctggg ctggccgggg ctttcgtggc     9900

cgccgggccg ctcggtggga cggaagcgtg tggagagacc gccaagggct gtagtctggg     9960

tccgcgagca aggttgccct gaactggggg ttggggggag cgcagcaaaa tggcggctgt    10020

tcccgagtct tgaatggaag acgcttgtga ggcgggctgt gaggtcgttg aaacaaggtg    10080

gggggcatgg tgggcggcaa gaacccaagg tcttgaggcc ttcgctaatg cgggaaagct    10140

cttattcggg tgagatgggc tggggcacca tctggggacc ctgacgtgaa gtttgtcact    10200

gactggagaa ctcggtttgt cgtctgttgc gggggcggca gttatggcgg tgccgttggg    10260

cagtgcaccc gtacctttgg gagcgcgcgc cctcgtcgtg tcgtgacgtc acccgttctg    10320

ttggcttata atgcagggtg gggccacctg ccggtaggtg tgcggtaggc ttttctccgt    10380

cgcaggacgc agggttcggg cctagggtag gctctcctga atcgacaggc gccggacctc    10440

tggtgagggg agggataagt gaggcgtcag tttctttggt cggttttatg tacctatctt    10500

cttaagtagc tgaagctccg gttttgaact atgcgctcgg ggttggcgag tgtgttttgt    10560

gaagtttttt aggcaccttt tgaaatgtaa tcatttgggt caatatgtaa ttttcagtgt    10620

tagactagta aattgtccgc taaattctgg ccgtttttgg cttttttgtt agacgtgttg    10680

acaattaatc atcggcatag tatatcggca tagtataata cgacaaggtg aggaactaaa    10740

ccatgggatc ggccattgaa caagatggat tgcacgcagg ttctccggcc gcttgggtgg    10800

agaggctatt cggctatgac tgggcacaac agacaatcgg ctgctctgat gccgccgtgt    10860

tccggctgtc agcgcagggg cgcccggttc tttttgtcaa gaccgacctg tccggtgccc    10920

tgaatgaact gcaggacgag gcagcgcggc tatcgtggct ggccacgacg ggcgttcctt    10980

gcgcagctgt gctcgacgtt gtcactgaag cgggaaggga ctggctgcta ttgggcgaag    11040

tgccggggca ggatctcctg tcatctcacc ttgctcctgc cgagaaagta tccatcatgg    11100

ctgatgcaat gcggcggctg catacgcttg atccggctac ctgcccattc gaccaccaag    11160

cgaaacatcg catcgagcga gcacgtactc ggatggaagc cggtcttgtc gatcaggatg    11220

atctggacga agagcatcag gggctcgcgc cagccgaact gttcgccagg ctcaaggcgc    11280

gcatgcccga cggcgatgat ctcgtcgtga cccatggcga tgcctgcttg ccgaatatca    11340

tggtggaaaa tggccgcttt tctggattca tcgactgtgg ccggctgggt gtggcggacc    11400

gctatcagga catagcgttg gctacccgtg atattgctga agagcttggc ggcgaatggg    11460

ctgaccgctt cctcgtgctt tacggtatcg ccgctcccga ttcgcagcgc atcgccttct    11520

atcgccttct tgacgagttc ttctgagggg atccgctgta agtctgcaga aattgatgat    11580

ctattaaaca ataaagatgt ccactaaaat ggaagttttt cctgtcatac tttgttaaga    11640

agggtgagaa cagagtacct acattttgaa tggaaggatt ggagctacgg gggtgggggt    11700

ggggtgggat tagataaatg cctgctcttt actgaaggct ctttactatt gctttatgat    11760

aatgtttcat agttggatat cataatttaa acaagcaaaa ccaaattaag ggccagctca    11820

ttcctcccac tcatgatcta tagatctata gatctctcgt gggatcattg tttttctctt    11880

gattcccact ttgtggttct aagtactgtg gtttccaaat gtgtcagttt catagcctga    11940

agaacgagat cagcagcctc tgttccacat acacttcatt ctcagtattg ttttgccaag    12000

ttctaattcc atcagacctc gacctgcagc ccctagataa cttcgtataa tgtatgctat    12060

acgaagttat gctaggtaac tataacggtc ctaaggtagc gagctagcga gactcagccc    12120

aggaggacca ggatcttgcc aaagcagtag catcccattt gtaccaaaac agtgttcttg    12180

ctctataaac cgtgttagca gctcagga                                       12208


<210>  15
<211>  7476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(97)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (98)..(7298)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (7299)..(7376)
<223>  Cassette LoxP Scar

<220>
<221>  misc_feature
<222>  (7377)..(7476)
<223>  Mouse Sequence

<400>  15
agcttggcag ggatcagcag cctgggttgg aaggaggggg tataaaagcc ccttcaccag       60

gagaagccgt cacacagatc cacaagctcc tgacaggatg gcttctcatc gtctgctcct      120

cctctgcctt gctggactgg tatttgtgtc tgaggctggc cctacggtga gtgtttctgt      180

gacatcccat tcctacattt aagattcacg ctaaatgaag tagaagtgac tccttccagc      240

tttgccaacc agcttttatt actagggcaa gggtacccag catctatttt taatataatt      300

aattcaaact tcaaaaagaa tgaagttcca ctgagcttac tgagctggga cttgaactct      360

gagcattcta cctcattgct ttggtgcatt aggtttgtaa tatctggtac ctctgtttcc      420

tcagatagat gatagaaata aagatatgat attaaggaag ctgttaatac tgaattttca      480

gaaaagtatc cctccataaa atgtatttgg gggacaaact gcaggagatt atattctggc      540

cctatagtta ttcaaaacgt atttattgat taatctttaa aaggcttagt gaacaatatt      600

ctagtcagat atctaattct taaatcctct agaagaatta actaatacta taaaatgggt      660

ctggatgtag ttctgacatt attttataac aactggtaag agggagtgac tatagcaaca      720

actaaaatga tctcaggaaa acctgtttgg ccctatgtat ggtacattac atcttttcag      780

taattccact caaatggaga cttttaacaa agcaactgtt ctcaggggac ctattttctc      840

ccttaaaatt cattatacac atccctggtt gatagcagtg tgtctggagg cagaaaccat      900

tcttgctttg gaaacaatta cgtctgtgtt atactgagta gggaagctca ttaattgtcg      960

acacttacgt tcctgataat gggatcagtg tgtaattctt gtttcgctcc agatttctaa     1020

taccacaaag aataaatcct ttcactctga tcaattttgt taacttctca cgtgtcttct     1080

ctacacccag ggcaccggtg aatccaagtg tcctctgatg gtcaaagttc tagatgctgt     1140

ccgaggcagt cctgccatca atgtggccgt gcatgtgttc agaaaggctg ctgatgacac     1200

ctgggagcca tttgcctctg ggtaagttgc caaagaaccc tcccacagga cttggtttta     1260

tcttcccgtt tgcccctcac ttggtagaga gaggctcaca tcatctgcta aagaatttac     1320

aagtagattg aaaaacgtag gcagaggtca agtatgccct ctgaaggatg ccctcttttt     1380

gttttgctta gctaggaagt gaccaggaac ctgagcatca tttaggggca gacagtagag     1440

aaaagaagga atcagaactc ctctcctcta gctgtggttt gcaacccttt tgggtcacag     1500

aacactttat gtaggtgatg aaaagtaaac attctatgcc cagaaaaaat gcacagatac     1560

acacacatac aaaatcatat atgtgatttt aggagtttca cagattccct ggtgtccctg     1620

ggtaacacca aagctaagtg tccttgtctt agaattttag gaaaaggtat aatgtgtatt     1680

aacccattaa caaaaggaaa ggaattcaga aatattatta accaggcatc tgtctgtagt     1740

taatatggat cacccaaaac ccaaggcttt tgcctaatga acactttggg gcacctactg     1800

tgtgcaaggc tgggggctgt caagctcagt taaaaaaaaa aagatagaag agatggatcc     1860

atgaggcaaa gtacagcccc aggctaatcc cacgatcacc cgacttcatg tccaagagtg     1920

gcttctcacc ttcattagcc agttcacaat tttcatggag tttttctacc tgcactagca     1980

aaaacttcaa ggaaaataca tattaataaa tctaagcaaa gtgaccagaa gacagagcaa     2040

tcaggagacc ctttgcatcc agcagaagag gaactgctaa gtatttacat ctccacagag     2100

aagaatttct gttgggtttt aattgaaccc caagaaccac atgattcttc aaccattatt     2160

gggaagatca ttttcttagg tctggtttta actggctttt tatttgggaa ttcatttatg     2220

tttatataaa atgccaagca taacatgaaa agtggttaca ggactattct aagggagaga     2280

cagaatggac accaaaaata ttccaatgtt cttgtgaatc ttttccttgc accaggacaa     2340

aaaaaaaaag aagtgaaaag aagaaaggag gaggggcata atcagagtca gtaaagacaa     2400

ctgctatttt tatctatcgt agctgttgca gtcaaatggg aagcaatttc caacattcaa     2460

ctatggagct ggtacttaca tggaaataga agttgcctag tgtttgttgc tggcaaagag     2520

ttatcagaga ggttaaatat ataaaaggga aaagagtcag atacaggttc ttcttcctac     2580

tttaggtttt ccactgtgtg tgcaaatgat actccctggt ggtgtgcaga tgcctcaaag     2640

ctatcctcac accacaaggg agaggagcga gatcctgctg tcctggagaa gtgcagagtt     2700

agaacagctg tggccacttg catccaatca tcaatcttga atcacaggga ctctttctta     2760

agtaaacatt atacctggcc gggcacggtg gctcacgcct gtaatcccag cactttggga     2820

tgccaaagtg ggcatatcat ctgaggtcag gagttcaaga ccagcctggc caacatggca     2880

aaactccgtc tttatgaaaa atacaaaaat tagccaggca tggtggcagg cgcctgtaat     2940

cccagctaat tgggaggctg aggctggaga atcccttgaa tctaggaggc agaggttgca     3000

gtgagctgag atcgtgccat tgcactccag cctgggtgac aagagtaaaa ctctgtctca     3060

aaaaaaaaaa attataccta cattctcttc ttatcagaga aaaaaatcta cagtgagctt     3120

ttcaaaaagt ttttacaaac tttttgccat ttaatttcag ttaggagttt tccctacttc     3180

tgacttagtt gaggggaaat gttcataaca tgtttataac atgtttatgt gtgttagttg     3240

gtgggggtgt attactttgc catgccattt gtttcctcca tgcgtaactt aatccagact     3300

ttcacacctt ataggaaaac cagtgagtct ggagagctgc atgggctcac aactgaggag     3360

gaatttgtag aagggatata caaagtggaa atagacacca aatcttactg gaaggcactt     3420

ggcatctccc cattccatga gcatgcagag gtgagtatac agaccttcga gggttgtttt     3480

ggttttggtt tttgcttttg gcattccagg aaatgcacag ttttactcag tgtaccacag     3540

aaatgtccta aggaaggtga tgaatgacca aaggttccct ttcctattat acaagaaaaa     3600

attcacaaca ctctgagaag caaatttctt tttgactttg atgaaaatcc acttagtaac     3660

atgacttgaa cttacatgaa actactcata gtctattcat tccactttat atgaatattg     3720

atgtatctgc tgttgaaata atagtttatg aggcagccct ccagacccca cgtagagtgt     3780

atgtaacaag agatgcacca ttttatttct cgaaaacccg taacattctt cattccaaaa     3840

cacatctggc ttctcggagg tctggacaag tgattcttgg caacacatac ctatagagac     3900

aataaaatca aagtaataat ggcaacacaa tagataacat ttaccaagca tacaccatgt     3960

ggcagacaca attataagtg ttttccatat ttaacctact taatcctcag gaataagcca     4020

ctgaggtcag tcctattatt atccccatct tatagatgaa gaaaatgagg caccaggaag     4080

tcaaataact tgtcaaaggt cacaagacta ggaaatacac aagtagaaat gtttacaatt     4140

aaggcccagg ctgggtttgc cctcagttct gctatgcctc gcattatgcc ccaggaaact     4200

ttttcccttg tgaaagccaa gcttaaaaaa agaaaagcca catttgtaac gtgctctgtt     4260

cccctgccta tggtgaggat cttcaaacag ttatacatgg acccagtccc cctgccttct     4320

ccttaatttc ttaagtcatt tgaaacagat ggctgtcatg gaaatagaat ccagacatgt     4380

tggtcagagt taaagatcaa ctaattccat caaaaatagc tcggcatgaa agggaactat     4440

tctctggctt agtcatggat gagactttca attgctataa agtggttcct ttattagaca     4500

atgttaccag ggaaacaaca ggggtttgtt tgacttctgg ggcccacaag tcaacaagag     4560

agccccatct accaaggagc atgtccctga ctacccctca gccagcagca agacatggac     4620

cccagtcagg gcaggagcag ggtttcggcg gcgcccagca caagacattg cccctagagt     4680

ctcagcccct accctcgagt aatagatctg cctacctgag actgttgttt gcccaagagc     4740

tgggtctcag cctgatggga accatataaa aaggttcact gacatactgc ccacatgttg     4800

ttctctttca ttagatctta gcttccttgt ctgctcttca ttcttgcagt attcattcaa     4860

caaacattaa aaaaaaaaaa aagcattcta tgtgtggaac actctgctag atgctgtgga     4920

tttagaaatg aaaatacatc ccgacccttg gaatggaagg gaaaggactg aagtaagaca     4980

gattaagcag gaccgtcagc ccagcttgaa gcccagataa atacggagaa caagagagag     5040

cgagtagtga gagatgagtc ccaatgcctc actttggtga cgggtgcgtg gtgggcttca     5100

tgcagcttct tctgataaat gcctccttca gaactggtca actctacctt ggccagtgac     5160

ccaggtggtc atagtagatt taccaaggga aaatggaaac ttttattagg agctcttagg     5220

cctcttcact tcatggattt ttttttcctt tttttttgag atggagtttt gccctgtcac     5280

ccaggctgga atgcagtggt gcaatctcag ctcactgcaa cctccgcctc ccaggttcaa     5340

gcaattctcc tgcctcagcc tcccgagtag ctgggactac aggtgtgcgc caccacacca     5400

ggctaatttt tgtatttttt gtaaagacag gttttcacca cgttggccag gctggtctga     5460

actccagacc tcaggtgatt cacctgtctc agcctcccaa agtgctggga ttacaggtgt     5520

gagccaccgt gcccggctac ttcatggatt tttgattaca gattatgcct cttacaattt     5580

ttaagaagaa tcaagtgggc tgaaggtcaa tgtcaccata agacaaaaga catttttatt     5640

agttgattct agggaattgg ccttaagggg agccctttct tcctaagaga ttcttaggtg     5700

attctcactt cctcttgccc cagtattatt tttgtttttg gtatggctca ctcagatcct     5760

tttttcctcc tatccctaag taatccgggt ttctttttcc catatttaga acaaaatgta     5820

tttatgcaga gtgtgtccaa acctcaaccc aaggcctgta tacaaaataa atcaaattaa     5880

acacatcttt actgtcttct acctctttcc tgacctcaat atatcccaac ttgcctcact     5940

ctgagaacca aggctgtccc agcacctgag tcgcagatat tctactgatt tgacagaact     6000

gtgtgactat ctggaacagc attttgatcc acaatttgcc cagttacaaa gcttaaatga     6060

gctctagtgc atgcatatat atttcaaaat tccaccatga tcttccacac tctgtattgt     6120

aaatagagcc ctgtaatgct tttacttcgt atttcattgc ttgttataca taaaaatata     6180

cttttcttct tcatgttaga aaatgcaaag aataggaggg tgggggaatc tctgggcttg     6240

gagacaggag acttgccttc ctactatggt tccatcagaa tgtagactgg gacaatacaa     6300

taattcaagt ctggtttgct catctgtaaa ttgggaagaa tgtttccagc tccagaatgc     6360

taaatctcta agtctgtggt tggcagccac tattgcagca gctcttcaat gactcaatgc     6420

agttttgcat tctccctacc ttttttttct aaaaccaata aaatagatac agcctttagg     6480

ctttctggga tttcccttag tcaagctagg gtcatcctga ctttcggcgt gaatttgcaa     6540

aacaagacct gactctgtac tcctgctcta aggactgtgc atggttccaa aggcttagct     6600

tgccagcata tttgagcttt ttccttctgt tcaaactgtt ccaaaatata aaagaataaa     6660

attaattaag ttggcactgg acttccggtg gtcagtcatg tgtgtcatct gtcacgtttt     6720

tcgggctctg gtggaaatgg atctgtctgt cttctctcat aggtggtatt cacagccaac     6780

gactccggcc cccgccgcta caccattgcc gccctgctga gcccctactc ctattccacc     6840

acggctgtcg tcaccaatcc caaggaatga gggacttctc ctccagtgga cctgaaggac     6900

gagggatggg atttcatgta accaagagta ttccattttt actaaagcag tgttttcacc     6960

tcatatgcta tgttagaagt ccaggcagag acaataaaac attcctgtga aaggcacttt     7020

tcattccact ttaacttgat tttttaaatt cccttattgt cccttccaaa aaaaagagaa     7080

tcaaaatttt acaaagaatc aaaggaattc tagaaagtat ctgggcagaa cgctaggaga     7140

gatccaaatt tccattgtct tgcaagcaaa gcacgtatta aatatgatct gcagccatta     7200

aaaagacaca ttctgtaaat gagagagcct tattttcctg taaccttcag caaatagcaa     7260

aagacacatt ccaagggccc acttctttac tgtgggcact cgagataact tcgtataatg     7320

tatgctatac gaagttatgc taggtaacta taacggtcct aaggtagcga gctagcgaga     7380

ctcagcccag gaggaccagg atcttgccaa agcagtagca tcccatttgt accaaaacag     7440

tgttcttgct ctataaaccg tgttagcagc tcagga                               7476


<210>  16
<211>  11218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(100)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (101)..(6308)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (6309)..(11118)
<223>  SDC Neo Cassette

<220>
<221>  misc_feature
<222>  (11119)..(11218)
<223>  Mouse Sequence

<400>  16
atgtactttt ggttttgttc cagagtctat caccggaaag aacaagccgg tttactctga       60

cccatttcac tgacatttct cttgtctcct ctgtgcccag ggcaccggtg aatccaagtg      120

tcctctgatg gtcaaagttc tagatgctgt ccgaggcagt cctgccatca atgtggccgt      180

gcatgtgttc agaaaggctg ctgatgacac ctgggagcca tttgcctctg ggtaagttgc      240

caaagaaccc tcccacagga cttggtttta tcttcccgtt tgcccctcac ttggtagaga      300

gaggctcaca tcatctgcta aagaatttac aagtagattg aaaaacgtag gcagaggtca      360

agtatgccct ctgaaggatg ccctcttttt gttttgctta gctaggaagt gaccaggaac      420

ctgagcatca tttaggggca gacagtagag aaaagaagga atcagaactc ctctcctcta      480

gctgtggttt gcaacccttt tgggtcacag aacactttat gtaggtgatg aaaagtaaac      540

attctatgcc cagaaaaaat gcacagatac acacacatac aaaatcatat atgtgatttt      600

aggagtttca cagattccct ggtgtccctg ggtaacacca aagctaagtg tccttgtctt      660

agaattttag gaaaaggtat aatgtgtatt aacccattaa caaaaggaaa ggaattcaga      720

aatattatta accaggcatc tgtctgtagt taatatggat cacccaaaac ccaaggcttt      780

tgcctaatga acactttggg gcacctactg tgtgcaaggc tgggggctgt caagctcagt      840

taaaaaaaaa aagatagaag agatggatcc atgaggcaaa gtacagcccc aggctaatcc      900

cacgatcacc cgacttcatg tccaagagtg gcttctcacc ttcattagcc agttcacaat      960

tttcatggag tttttctacc tgcactagca aaaacttcaa ggaaaataca tattaataaa     1020

tctaagcaaa gtgaccagaa gacagagcaa tcaggagacc ctttgcatcc agcagaagag     1080

gaactgctaa gtatttacat ctccacagag aagaatttct gttgggtttt aattgaaccc     1140

caagaaccac atgattcttc aaccattatt gggaagatca ttttcttagg tctggtttta     1200

actggctttt tatttgggaa ttcatttatg tttatataaa atgccaagca taacatgaaa     1260

agtggttaca ggactattct aagggagaga cagaatggac accaaaaata ttccaatgtt     1320

cttgtgaatc ttttccttgc accaggacaa aaaaaaaaag aagtgaaaag aagaaaggag     1380

gaggggcata atcagagtca gtaaagacaa ctgctatttt tatctatcgt agctgttgca     1440

gtcaaatggg aagcaatttc caacattcaa ctatggagct ggtacttaca tggaaataga     1500

agttgcctag tgtttgttgc tggcaaagag ttatcagaga ggttaaatat ataaaaggga     1560

aaagagtcag atacaggttc ttcttcctac tttaggtttt ccactgtgtg tgcaaatgat     1620

actccctggt ggtgtgcaga tgcctcaaag ctatcctcac accacaaggg agaggagcga     1680

gatcctgctg tcctggagaa gtgcagagtt agaacagctg tggccacttg catccaatca     1740

tcaatcttga atcacaggga ctctttctta agtaaacatt atacctggcc gggcacggtg     1800

gctcacgcct gtaatcccag cactttggga tgccaaagtg ggcatatcat ctgaggtcag     1860

gagttcaaga ccagcctggc caacatggca aaactccgtc tttatgaaaa atacaaaaat     1920

tagccaggca tggtggcagg cgcctgtaat cccagctaat tgggaggctg aggctggaga     1980

atcccttgaa tctaggaggc agaggttgca gtgagctgag atcgtgccat tgcactccag     2040

cctgggtgac aagagtaaaa ctctgtctca aaaaaaaaaa attataccta cattctcttc     2100

ttatcagaga aaaaaatcta cagtgagctt ttcaaaaagt ttttacaaac tttttgccat     2160

ttaatttcag ttaggagttt tccctacttc tgacttagtt gaggggaaat gttcataaca     2220

tgtttataac atgtttatgt gtgttagttg gtgggggtgt attactttgc catgccattt     2280

gtttcctcca tgcgtaactt aatccagact ttcacacctt ataggaaaac cagtgagtct     2340

ggagagctgc atgggctcac aactgaggag gaatttgtag aagggatata caaagtggaa     2400

atagacacca aatcttactg gaaggcactt ggcatctccc cattccatga gcatgcagag     2460

gtgagtatac agaccttcga gggttgtttt ggttttggtt tttgcttttg gcattccagg     2520

aaatgcacag ttttactcag tgtaccacag aaatgtccta aggaaggtga tgaatgacca     2580

aaggttccct ttcctattat acaagaaaaa attcacaaca ctctgagaag caaatttctt     2640

tttgactttg atgaaaatcc acttagtaac atgacttgaa cttacatgaa actactcata     2700

gtctattcat tccactttat atgaatattg atgtatctgc tgttgaaata atagtttatg     2760

aggcagccct ccagacccca cgtagagtgt atgtaacaag agatgcacca ttttatttct     2820

cgaaaacccg taacattctt cattccaaaa cacatctggc ttctcggagg tctggacaag     2880

tgattcttgg caacacatac ctatagagac aataaaatca aagtaataat ggcaacacaa     2940

tagataacat ttaccaagca tacaccatgt ggcagacaca attataagtg ttttccatat     3000

ttaacctact taatcctcag gaataagcca ctgaggtcag tcctattatt atccccatct     3060

tatagatgaa gaaaatgagg caccaggaag tcaaataact tgtcaaaggt cacaagacta     3120

ggaaatacac aagtagaaat gtttacaatt aaggcccagg ctgggtttgc cctcagttct     3180

gctatgcctc gcattatgcc ccaggaaact ttttcccttg tgaaagccaa gcttaaaaaa     3240

agaaaagcca catttgtaac gtgctctgtt cccctgccta tggtgaggat cttcaaacag     3300

ttatacatgg acccagtccc cctgccttct ccttaatttc ttaagtcatt tgaaacagat     3360

ggctgtcatg gaaatagaat ccagacatgt tggtcagagt taaagatcaa ctaattccat     3420

caaaaatagc tcggcatgaa agggaactat tctctggctt agtcatggat gagactttca     3480

attgctataa agtggttcct ttattagaca atgttaccag ggaaacaaca ggggtttgtt     3540

tgacttctgg ggcccacaag tcaacaagag agccccatct accaaggagc atgtccctga     3600

ctacccctca gccagcagca agacatggac cccagtcagg gcaggagcag ggtttcggcg     3660

gcgcccagca caagacattg cccctagagt ctcagcccct accctcgagt aatagatctg     3720

cctacctgag actgttgttt gcccaagagc tgggtctcag cctgatggga accatataaa     3780

aaggttcact gacatactgc ccacatgttg ttctctttca ttagatctta gcttccttgt     3840

ctgctcttca ttcttgcagt attcattcaa caaacattaa aaaaaaaaaa aagcattcta     3900

tgtgtggaac actctgctag atgctgtgga tttagaaatg aaaatacatc ccgacccttg     3960

gaatggaagg gaaaggactg aagtaagaca gattaagcag gaccgtcagc ccagcttgaa     4020

gcccagataa atacggagaa caagagagag cgagtagtga gagatgagtc ccaatgcctc     4080

actttggtga cgggtgcgtg gtgggcttca tgcagcttct tctgataaat gcctccttca     4140

gaactggtca actctacctt ggccagtgac ccaggtggtc atagtagatt taccaaggga     4200

aaatggaaac ttttattagg agctcttagg cctcttcact tcatggattt ttttttcctt     4260

tttttttgag atggagtttt gccctgtcac ccaggctgga atgcagtggt gcaatctcag     4320

ctcactgcaa cctccgcctc ccaggttcaa gcaattctcc tgcctcagcc tcccgagtag     4380

ctgggactac aggtgtgcgc caccacacca ggctaatttt tgtatttttt gtaaagacag     4440

gttttcacca cgttggccag gctggtctga actccagacc tcaggtgatt cacctgtctc     4500

agcctcccaa agtgctggga ttacaggtgt gagccaccgt gcccggctac ttcatggatt     4560

tttgattaca gattatgcct cttacaattt ttaagaagaa tcaagtgggc tgaaggtcaa     4620

tgtcaccata agacaaaaga catttttatt agttgattct agggaattgg ccttaagggg     4680

agccctttct tcctaagaga ttcttaggtg attctcactt cctcttgccc cagtattatt     4740

tttgtttttg gtatggctca ctcagatcct tttttcctcc tatccctaag taatccgggt     4800

ttctttttcc catatttaga acaaaatgta tttatgcaga gtgtgtccaa acctcaaccc     4860

aaggcctgta tacaaaataa atcaaattaa acacatcttt actgtcttct acctctttcc     4920

tgacctcaat atatcccaac ttgcctcact ctgagaacca aggctgtccc agcacctgag     4980

tcgcagatat tctactgatt tgacagaact gtgtgactat ctggaacagc attttgatcc     5040

acaatttgcc cagttacaaa gcttaaatga gctctagtgc atgcatatat atttcaaaat     5100

tccaccatga tcttccacac tctgtattgt aaatagagcc ctgtaatgct tttacttcgt     5160

atttcattgc ttgttataca taaaaatata cttttcttct tcatgttaga aaatgcaaag     5220

aataggaggg tgggggaatc tctgggcttg gagacaggag acttgccttc ctactatggt     5280

tccatcagaa tgtagactgg gacaatacaa taattcaagt ctggtttgct catctgtaaa     5340

ttgggaagaa tgtttccagc tccagaatgc taaatctcta agtctgtggt tggcagccac     5400

tattgcagca gctcttcaat gactcaatgc agttttgcat tctccctacc ttttttttct     5460

aaaaccaata aaatagatac agcctttagg ctttctggga tttcccttag tcaagctagg     5520

gtcatcctga ctttcggcgt gaatttgcaa aacaagacct gactctgtac tcctgctcta     5580

aggactgtgc atggttccaa aggcttagct tgccagcata tttgagcttt ttccttctgt     5640

tcaaactgtt ccaaaatata aaagaataaa attaattaag ttggcactgg acttccggtg     5700

gtcagtcatg tgtgtcatct gtcacgtttt tcgggctctg gtggaaatgg atctgtctgt     5760

cttctctcat aggtggtatt cacagccaac gactccggcc cccgccgcta caccattgcc     5820

gccctgctga gcccctactc ctattccacc acggctgtcg tcaccaatcc caaggaatga     5880

gggacttctc ctccagtgga cctgaaggac gagggatggg atttcatgta accaagagta     5940

ttccattttt actaaagcag tgttttcacc tcatatgcta tgttagaagt ccaggcagag     6000

acaataaaac attcctgtga aaggcacttt tcattccact ttaacttgat tttttaaatt     6060

cccttattgt cccttccaaa aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc     6120

tagaaagtat ctgggcagaa cgctaggaga gatccaaatt tccattgtct tgcaagcaaa     6180

gcacgtatta aatatgatct gcagccatta aaaagacaca ttctgtaaat gagagagcct     6240

tattttcctg taaccttcag caaatagcaa aagacacatt ccaagggccc acttctttac     6300

tgtgggcact cgagataact tcgtataatg tatgctatac gaagttatat gcatgccagt     6360

agcagcaccc acgtccacct tctgtctagt aatgtccaac acctccctca gtccaaacac     6420

tgctctgcat ccatgtggct cccatttata cctgaagcac ttgatggggc ctcaatgttt     6480

tactagagcc cacccccctg caactctgag accctctgga tttgtctgtc agtgcctcac     6540

tggggcgttg gataatttct taaaaggtca agttccctca gcagcattct ctgagcagtc     6600

tgaagatgtg tgcttttcac agttcaaatc catgtggctg tttcacccac ctgcctggcc     6660

ttgggttatc tatcaggacc tagcctagaa gcaggtgtgt ggcacttaac acctaagctg     6720

agtgactaac tgaacactca agtggatgcc atctttgtca cttcttgact gtgacacaag     6780

caactcctga tgccaaagcc ctgcccaccc ctctcatgcc catatttgga catggtacag     6840

gtcctcactg gccatggtct gtgaggtcct ggtcctcttt gacttcataa ttcctagggg     6900

ccactagtat ctataagagg aagagggtgc tggctcccag gccacagccc acaaaattcc     6960

acctgctcac aggttggctg gctcgaccca ggtggtgtcc cctgctctga gccagctccc     7020

ggccaagcca gcaccatggg aacccccaag aagaagagga aggtgcgtac cgatttaaat     7080

tccaatttac tgaccgtaca ccaaaatttg cctgcattac cggtcgatgc aacgagtgat     7140

gaggttcgca agaacctgat ggacatgttc agggatcgcc aggcgttttc tgagcatacc     7200

tggaaaatgc ttctgtccgt ttgccggtcg tgggcggcat ggtgcaagtt gaataaccgg     7260

aaatggtttc ccgcagaacc tgaagatgtt cgcgattatc ttctatatct tcaggcgcgc     7320

ggtctggcag taaaaactat ccagcaacat ttgggccagc taaacatgct tcatcgtcgg     7380

tccgggctgc cacgaccaag tgacagcaat gctgtttcac tggttatgcg gcggatccga     7440

aaagaaaacg ttgatgccgg tgaacgtgca aaacaggtaa atataaaatt tttaagtgta     7500

taatgatgtt aaactactga ttctaattgt ttgtgtattt taggctctag cgttcgaacg     7560

cactgatttc gaccaggttc gttcactcat ggaaaatagc gatcgctgcc aggatatacg     7620

taatctggca tttctgggga ttgcttataa caccctgtta cgtatagccg aaattgccag     7680

gatcagggtt aaagatatct cacgtactga cggtgggaga atgttaatcc atattggcag     7740

aacgaaaacg ctggttagca ccgcaggtgt agagaaggca cttagcctgg gggtaactaa     7800

actggtcgag cgatggattt ccgtctctgg tgtagctgat gatccgaata actacctgtt     7860

ttgccgggtc agaaaaaatg gtgttgccgc gccatctgcc accagccagc tatcaactcg     7920

cgccctggaa gggatttttg aagcaactca tcgattgatt tacggcgcta aggatgactc     7980

tggtcagaga tacctggcct ggtctggaca cagtgcccgt gtcggagccg cgcgagatat     8040

ggcccgcgct ggagtttcaa taccggagat catgcaagct ggtggctgga ccaatgtaaa     8100

tattgtcatg aactatatcc gtaacctgga tagtgaaaca ggggcaatgg tgcgcctgct     8160

ggaagatggc gattaggcgg ccggccgcta atcagccata ccacatttgt agaggtttta     8220

cttgctttaa aaaacctccc acacctcccc ctgaacctga aacataaaat gaatgcaatt     8280

gttgttgtta acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca     8340

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc     8400

aatgtatctt atcatgtctg gatcccccgg ctagagttta aacactagaa ctagtggatc     8460

ccccgggatc atggcctccg cgccgggttt tggcgcctcc cgcgggcgcc cccctcctca     8520

cggcgagcgc tgccacgtca gacgaagggc gcagcgagcg tcctgatcct tccgcccgga     8580

cgctcaggac agcggcccgc tgctcataag actcggcctt agaaccccag tatcagcaga     8640

aggacatttt aggacgggac ttgggtgact ctagggcact ggttttcttt ccagagagcg     8700

gaacaggcga ggaaaagtag tcccttctcg gcgattctgc ggagggatct ccgtggggcg     8760

gtgaacgccg atgattatat aaggacgcgc cgggtgtggc acagctagtt ccgtcgcagc     8820

cgggatttgg gtcgcggttc ttgtttgtgg atcgctgtga tcgtcacttg gtgagtagcg     8880

ggctgctggg ctggccgggg ctttcgtggc cgccgggccg ctcggtggga cggaagcgtg     8940

tggagagacc gccaagggct gtagtctggg tccgcgagca aggttgccct gaactggggg     9000

ttggggggag cgcagcaaaa tggcggctgt tcccgagtct tgaatggaag acgcttgtga     9060

ggcgggctgt gaggtcgttg aaacaaggtg gggggcatgg tgggcggcaa gaacccaagg     9120

tcttgaggcc ttcgctaatg cgggaaagct cttattcggg tgagatgggc tggggcacca     9180

tctggggacc ctgacgtgaa gtttgtcact gactggagaa ctcggtttgt cgtctgttgc     9240

gggggcggca gttatggcgg tgccgttggg cagtgcaccc gtacctttgg gagcgcgcgc     9300

cctcgtcgtg tcgtgacgtc acccgttctg ttggcttata atgcagggtg gggccacctg     9360

ccggtaggtg tgcggtaggc ttttctccgt cgcaggacgc agggttcggg cctagggtag     9420

gctctcctga atcgacaggc gccggacctc tggtgagggg agggataagt gaggcgtcag     9480

tttctttggt cggttttatg tacctatctt cttaagtagc tgaagctccg gttttgaact     9540

atgcgctcgg ggttggcgag tgtgttttgt gaagtttttt aggcaccttt tgaaatgtaa     9600

tcatttgggt caatatgtaa ttttcagtgt tagactagta aattgtccgc taaattctgg     9660

ccgtttttgg cttttttgtt agacgtgttg acaattaatc atcggcatag tatatcggca     9720

tagtataata cgacaaggtg aggaactaaa ccatgggatc ggccattgaa caagatggat     9780

tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac tgggcacaac     9840

agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg cgcccggttc     9900

tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaggacgag gcagcgcggc     9960

tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag    10020

cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg tcatctcacc    10080

ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg catacgcttg    10140

atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga gcacgtactc    10200

ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag gggctcgcgc    10260

cagccgaact gttcgccagg ctcaaggcgc gcatgcccga cggcgatgat ctcgtcgtga    10320

cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt tctggattca    10380

tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg gctacccgtg    10440

atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg    10500

ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc ttctgagggg    10560

atccgctgta agtctgcaga aattgatgat ctattaaaca ataaagatgt ccactaaaat    10620

ggaagttttt cctgtcatac tttgttaaga agggtgagaa cagagtacct acattttgaa    10680

tggaaggatt ggagctacgg gggtgggggt ggggtgggat tagataaatg cctgctcttt    10740

actgaaggct ctttactatt gctttatgat aatgtttcat agttggatat cataatttaa    10800

acaagcaaaa ccaaattaag ggccagctca ttcctcccac tcatgatcta tagatctata    10860

gatctctcgt gggatcattg tttttctctt gattcccact ttgtggttct aagtactgtg    10920

gtttccaaat gtgtcagttt catagcctga agaacgagat cagcagcctc tgttccacat    10980

acacttcatt ctcagtattg ttttgccaag ttctaattcc atcagacctc gacctgcagc    11040

ccctagataa cttcgtataa tgtatgctat acgaagttat gctaggtaac tataacggtc    11100

ctaaggtagc gagctagcga gactcagccc aggaggacca ggatcttgcc aaagcagtag    11160

catcccattt gtaccaaaac agtgttcttg ctctataaac cgtgttagca gctcagga      11218


<210>  17
<211>  6486
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(100)
<223>  Mouse Sequence

<220>
<221>  misc_feature
<222>  (101)..(6308)
<223>  Human Sequence

<220>
<221>  misc_feature
<222>  (6309)..(6386)
<223>  Cassette LoxP Scar

<220>
<221>  misc_feature
<222>  (6387)..(6486)
<223>  Mouse Sequence

<400>  17
atgtactttt ggttttgttc cagagtctat caccggaaag aacaagccgg tttactctga       60

cccatttcac tgacatttct cttgtctcct ctgtgcccag ggcaccggtg aatccaagtg      120

tcctctgatg gtcaaagttc tagatgctgt ccgaggcagt cctgccatca atgtggccgt      180

gcatgtgttc agaaaggctg ctgatgacac ctgggagcca tttgcctctg ggtaagttgc      240

caaagaaccc tcccacagga cttggtttta tcttcccgtt tgcccctcac ttggtagaga      300

gaggctcaca tcatctgcta aagaatttac aagtagattg aaaaacgtag gcagaggtca      360

agtatgccct ctgaaggatg ccctcttttt gttttgctta gctaggaagt gaccaggaac      420

ctgagcatca tttaggggca gacagtagag aaaagaagga atcagaactc ctctcctcta      480

gctgtggttt gcaacccttt tgggtcacag aacactttat gtaggtgatg aaaagtaaac      540

attctatgcc cagaaaaaat gcacagatac acacacatac aaaatcatat atgtgatttt      600

aggagtttca cagattccct ggtgtccctg ggtaacacca aagctaagtg tccttgtctt      660

agaattttag gaaaaggtat aatgtgtatt aacccattaa caaaaggaaa ggaattcaga      720

aatattatta accaggcatc tgtctgtagt taatatggat cacccaaaac ccaaggcttt      780

tgcctaatga acactttggg gcacctactg tgtgcaaggc tgggggctgt caagctcagt      840

taaaaaaaaa aagatagaag agatggatcc atgaggcaaa gtacagcccc aggctaatcc      900

cacgatcacc cgacttcatg tccaagagtg gcttctcacc ttcattagcc agttcacaat      960

tttcatggag tttttctacc tgcactagca aaaacttcaa ggaaaataca tattaataaa     1020

tctaagcaaa gtgaccagaa gacagagcaa tcaggagacc ctttgcatcc agcagaagag     1080

gaactgctaa gtatttacat ctccacagag aagaatttct gttgggtttt aattgaaccc     1140

caagaaccac atgattcttc aaccattatt gggaagatca ttttcttagg tctggtttta     1200

actggctttt tatttgggaa ttcatttatg tttatataaa atgccaagca taacatgaaa     1260

agtggttaca ggactattct aagggagaga cagaatggac accaaaaata ttccaatgtt     1320

cttgtgaatc ttttccttgc accaggacaa aaaaaaaaag aagtgaaaag aagaaaggag     1380

gaggggcata atcagagtca gtaaagacaa ctgctatttt tatctatcgt agctgttgca     1440

gtcaaatggg aagcaatttc caacattcaa ctatggagct ggtacttaca tggaaataga     1500

agttgcctag tgtttgttgc tggcaaagag ttatcagaga ggttaaatat ataaaaggga     1560

aaagagtcag atacaggttc ttcttcctac tttaggtttt ccactgtgtg tgcaaatgat     1620

actccctggt ggtgtgcaga tgcctcaaag ctatcctcac accacaaggg agaggagcga     1680

gatcctgctg tcctggagaa gtgcagagtt agaacagctg tggccacttg catccaatca     1740

tcaatcttga atcacaggga ctctttctta agtaaacatt atacctggcc gggcacggtg     1800

gctcacgcct gtaatcccag cactttggga tgccaaagtg ggcatatcat ctgaggtcag     1860

gagttcaaga ccagcctggc caacatggca aaactccgtc tttatgaaaa atacaaaaat     1920

tagccaggca tggtggcagg cgcctgtaat cccagctaat tgggaggctg aggctggaga     1980

atcccttgaa tctaggaggc agaggttgca gtgagctgag atcgtgccat tgcactccag     2040

cctgggtgac aagagtaaaa ctctgtctca aaaaaaaaaa attataccta cattctcttc     2100

ttatcagaga aaaaaatcta cagtgagctt ttcaaaaagt ttttacaaac tttttgccat     2160

ttaatttcag ttaggagttt tccctacttc tgacttagtt gaggggaaat gttcataaca     2220

tgtttataac atgtttatgt gtgttagttg gtgggggtgt attactttgc catgccattt     2280

gtttcctcca tgcgtaactt aatccagact ttcacacctt ataggaaaac cagtgagtct     2340

ggagagctgc atgggctcac aactgaggag gaatttgtag aagggatata caaagtggaa     2400

atagacacca aatcttactg gaaggcactt ggcatctccc cattccatga gcatgcagag     2460

gtgagtatac agaccttcga gggttgtttt ggttttggtt tttgcttttg gcattccagg     2520

aaatgcacag ttttactcag tgtaccacag aaatgtccta aggaaggtga tgaatgacca     2580

aaggttccct ttcctattat acaagaaaaa attcacaaca ctctgagaag caaatttctt     2640

tttgactttg atgaaaatcc acttagtaac atgacttgaa cttacatgaa actactcata     2700

gtctattcat tccactttat atgaatattg atgtatctgc tgttgaaata atagtttatg     2760

aggcagccct ccagacccca cgtagagtgt atgtaacaag agatgcacca ttttatttct     2820

cgaaaacccg taacattctt cattccaaaa cacatctggc ttctcggagg tctggacaag     2880

tgattcttgg caacacatac ctatagagac aataaaatca aagtaataat ggcaacacaa     2940

tagataacat ttaccaagca tacaccatgt ggcagacaca attataagtg ttttccatat     3000

ttaacctact taatcctcag gaataagcca ctgaggtcag tcctattatt atccccatct     3060

tatagatgaa gaaaatgagg caccaggaag tcaaataact tgtcaaaggt cacaagacta     3120

ggaaatacac aagtagaaat gtttacaatt aaggcccagg ctgggtttgc cctcagttct     3180

gctatgcctc gcattatgcc ccaggaaact ttttcccttg tgaaagccaa gcttaaaaaa     3240

agaaaagcca catttgtaac gtgctctgtt cccctgccta tggtgaggat cttcaaacag     3300

ttatacatgg acccagtccc cctgccttct ccttaatttc ttaagtcatt tgaaacagat     3360

ggctgtcatg gaaatagaat ccagacatgt tggtcagagt taaagatcaa ctaattccat     3420

caaaaatagc tcggcatgaa agggaactat tctctggctt agtcatggat gagactttca     3480

attgctataa agtggttcct ttattagaca atgttaccag ggaaacaaca ggggtttgtt     3540

tgacttctgg ggcccacaag tcaacaagag agccccatct accaaggagc atgtccctga     3600

ctacccctca gccagcagca agacatggac cccagtcagg gcaggagcag ggtttcggcg     3660

gcgcccagca caagacattg cccctagagt ctcagcccct accctcgagt aatagatctg     3720

cctacctgag actgttgttt gcccaagagc tgggtctcag cctgatggga accatataaa     3780

aaggttcact gacatactgc ccacatgttg ttctctttca ttagatctta gcttccttgt     3840

ctgctcttca ttcttgcagt attcattcaa caaacattaa aaaaaaaaaa aagcattcta     3900

tgtgtggaac actctgctag atgctgtgga tttagaaatg aaaatacatc ccgacccttg     3960

gaatggaagg gaaaggactg aagtaagaca gattaagcag gaccgtcagc ccagcttgaa     4020

gcccagataa atacggagaa caagagagag cgagtagtga gagatgagtc ccaatgcctc     4080

actttggtga cgggtgcgtg gtgggcttca tgcagcttct tctgataaat gcctccttca     4140

gaactggtca actctacctt ggccagtgac ccaggtggtc atagtagatt taccaaggga     4200

aaatggaaac ttttattagg agctcttagg cctcttcact tcatggattt ttttttcctt     4260

tttttttgag atggagtttt gccctgtcac ccaggctgga atgcagtggt gcaatctcag     4320

ctcactgcaa cctccgcctc ccaggttcaa gcaattctcc tgcctcagcc tcccgagtag     4380

ctgggactac aggtgtgcgc caccacacca ggctaatttt tgtatttttt gtaaagacag     4440

gttttcacca cgttggccag gctggtctga actccagacc tcaggtgatt cacctgtctc     4500

agcctcccaa agtgctggga ttacaggtgt gagccaccgt gcccggctac ttcatggatt     4560

tttgattaca gattatgcct cttacaattt ttaagaagaa tcaagtgggc tgaaggtcaa     4620

tgtcaccata agacaaaaga catttttatt agttgattct agggaattgg ccttaagggg     4680

agccctttct tcctaagaga ttcttaggtg attctcactt cctcttgccc cagtattatt     4740

tttgtttttg gtatggctca ctcagatcct tttttcctcc tatccctaag taatccgggt     4800

ttctttttcc catatttaga acaaaatgta tttatgcaga gtgtgtccaa acctcaaccc     4860

aaggcctgta tacaaaataa atcaaattaa acacatcttt actgtcttct acctctttcc     4920

tgacctcaat atatcccaac ttgcctcact ctgagaacca aggctgtccc agcacctgag     4980

tcgcagatat tctactgatt tgacagaact gtgtgactat ctggaacagc attttgatcc     5040

acaatttgcc cagttacaaa gcttaaatga gctctagtgc atgcatatat atttcaaaat     5100

tccaccatga tcttccacac tctgtattgt aaatagagcc ctgtaatgct tttacttcgt     5160

atttcattgc ttgttataca taaaaatata cttttcttct tcatgttaga aaatgcaaag     5220

aataggaggg tgggggaatc tctgggcttg gagacaggag acttgccttc ctactatggt     5280

tccatcagaa tgtagactgg gacaatacaa taattcaagt ctggtttgct catctgtaaa     5340

ttgggaagaa tgtttccagc tccagaatgc taaatctcta agtctgtggt tggcagccac     5400

tattgcagca gctcttcaat gactcaatgc agttttgcat tctccctacc ttttttttct     5460

aaaaccaata aaatagatac agcctttagg ctttctggga tttcccttag tcaagctagg     5520

gtcatcctga ctttcggcgt gaatttgcaa aacaagacct gactctgtac tcctgctcta     5580

aggactgtgc atggttccaa aggcttagct tgccagcata tttgagcttt ttccttctgt     5640

tcaaactgtt ccaaaatata aaagaataaa attaattaag ttggcactgg acttccggtg     5700

gtcagtcatg tgtgtcatct gtcacgtttt tcgggctctg gtggaaatgg atctgtctgt     5760

cttctctcat aggtggtatt cacagccaac gactccggcc cccgccgcta caccattgcc     5820

gccctgctga gcccctactc ctattccacc acggctgtcg tcaccaatcc caaggaatga     5880

gggacttctc ctccagtgga cctgaaggac gagggatggg atttcatgta accaagagta     5940

ttccattttt actaaagcag tgttttcacc tcatatgcta tgttagaagt ccaggcagag     6000

acaataaaac attcctgtga aaggcacttt tcattccact ttaacttgat tttttaaatt     6060

cccttattgt cccttccaaa aaaaagagaa tcaaaatttt acaaagaatc aaaggaattc     6120

tagaaagtat ctgggcagaa cgctaggaga gatccaaatt tccattgtct tgcaagcaaa     6180

gcacgtatta aatatgatct gcagccatta aaaagacaca ttctgtaaat gagagagcct     6240

tattttcctg taaccttcag caaatagcaa aagacacatt ccaagggccc acttctttac     6300

tgtgggcact cgagataact tcgtataatg tatgctatac gaagttatgc taggtaacta     6360

taacggtcct aaggtagcga gctagcgaga ctcagcccag gaggaccagg atcttgccaa     6420

agcagtagca tcccatttgt accaaaacag tgttcttgct ctataaaccg tgttagcagc     6480

tcagga                                                                6486


<210>  18
<211>  7201
<212>  DNA
<213>  Homo sapiens

<400>  18
atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct       60

ggccctacgg tgagtgtttc tgtgacatcc cattcctaca tttaagattc acgctaaatg      120

aagtagaagt gactccttcc agctttgcca accagctttt attactaggg caagggtacc      180

cagcatctat ttttaatata attaattcaa acttcaaaaa gaatgaagtt ccactgagct      240

tactgagctg ggacttgaac tctgagcatt ctacctcatt gctttggtgc attaggtttg      300

taatatctgg tacctctgtt tcctcagata gatgatagaa ataaagatat gatattaagg      360

aagctgttaa tactgaattt tcagaaaagt atccctccat aaaatgtatt tgggggacaa      420

actgcaggag attatattct ggccctatag ttattcaaaa cgtatttatt gattaatctt      480

taaaaggctt agtgaacaat attctagtca gatatctaat tcttaaatcc tctagaagaa      540

ttaactaata ctataaaatg ggtctggatg tagttctgac attattttat aacaactggt      600

aagagggagt gactatagca acaactaaaa tgatctcagg aaaacctgtt tggccctatg      660

tatggtacat tacatctttt cagtaattcc actcaaatgg agacttttaa caaagcaact      720

gttctcaggg gacctatttt ctcccttaaa attcattata cacatccctg gttgatagca      780

gtgtgtctgg aggcagaaac cattcttgct ttggaaacaa ttacgtctgt gttatactga      840

gtagggaagc tcattaattg tcgacactta cgttcctgat aatgggatca gtgtgtaatt      900

cttgtttcgc tccagatttc taataccaca aagaataaat cctttcactc tgatcaattt      960

tgttaacttc tcacgtgtct tctctacacc cagggcaccg gtgaatccaa gtgtcctctg     1020

atggtcaaag ttctagatgc tgtccgaggc agtcctgcca tcaatgtggc cgtgcatgtg     1080

ttcagaaagg ctgctgatga cacctgggag ccatttgcct ctgggtaagt tgccaaagaa     1140

ccctcccaca ggacttggtt ttatcttccc gtttgcccct cacttggtag agagaggctc     1200

acatcatctg ctaaagaatt tacaagtaga ttgaaaaacg taggcagagg tcaagtatgc     1260

cctctgaagg atgccctctt tttgttttgc ttagctagga agtgaccagg aacctgagca     1320

tcatttaggg gcagacagta gagaaaagaa ggaatcagaa ctcctctcct ctagctgtgg     1380

tttgcaaccc ttttgggtca cagaacactt tatgtaggtg atgaaaagta aacattctat     1440

gcccagaaaa aatgcacaga tacacacaca tacaaaatca tatatgtgat tttaggagtt     1500

tcacagattc cctggtgtcc ctgggtaaca ccaaagctaa gtgtccttgt cttagaattt     1560

taggaaaagg tataatgtgt attaacccat taacaaaagg aaaggaattc agaaatatta     1620

ttaaccaggc atctgtctgt agttaatatg gatcacccaa aacccaaggc ttttgcctaa     1680

tgaacacttt ggggcaccta ctgtgtgcaa ggctgggggc tgtcaagctc agttaaaaaa     1740

aaaaagatag aagagatgga tccatgaggc aaagtacagc cccaggctaa tcccacgatc     1800

acccgacttc atgtccaaga gtggcttctc accttcatta gccagttcac aattttcatg     1860

gagtttttct acctgcacta gcaaaaactt caaggaaaat acatattaat aaatctaagc     1920

aaagtgacca gaagacagag caatcaggag accctttgca tccagcagaa gaggaactgc     1980

taagtattta catctccaca gagaagaatt tctgttgggt tttaattgaa ccccaagaac     2040

cacatgattc ttcaaccatt attgggaaga tcattttctt aggtctggtt ttaactggct     2100

ttttatttgg gaattcattt atgtttatat aaaatgccaa gcataacatg aaaagtggtt     2160

acaggactat tctaagggag agacagaatg gacaccaaaa atattccaat gttcttgtga     2220

atcttttcct tgcaccagga caaaaaaaaa aagaagtgaa aagaagaaag gaggaggggc     2280

ataatcagag tcagtaaaga caactgctat ttttatctat cgtagctgtt gcagtcaaat     2340

gggaagcaat ttccaacatt caactatgga gctggtactt acatggaaat agaagttgcc     2400

tagtgtttgt tgctggcaaa gagttatcag agaggttaaa tatataaaag ggaaaagagt     2460

cagatacagg ttcttcttcc tactttaggt tttccactgt gtgtgcaaat gatactccct     2520

ggtggtgtgc agatgcctca aagctatcct cacaccacaa gggagaggag cgagatcctg     2580

ctgtcctgga gaagtgcaga gttagaacag ctgtggccac ttgcatccaa tcatcaatct     2640

tgaatcacag ggactctttc ttaagtaaac attatacctg gccgggcacg gtggctcacg     2700

cctgtaatcc cagcactttg ggatgccaaa gtgggcatat catctgaggt caggagttca     2760

agaccagcct ggccaacatg gcaaaactcc gtctttatga aaaatacaaa aattagccag     2820

gcatggtggc aggcgcctgt aatcccagct aattgggagg ctgaggctgg agaatccctt     2880

gaatctagga ggcagaggtt gcagtgagct gagatcgtgc cattgcactc cagcctgggt     2940

gacaagagta aaactctgtc tcaaaaaaaa aaaattatac ctacattctc ttcttatcag     3000

agaaaaaaat ctacagtgag cttttcaaaa agtttttaca aactttttgc catttaattt     3060

cagttaggag ttttccctac ttctgactta gttgagggga aatgttcata acatgtttat     3120

aacatgttta tgtgtgttag ttggtggggg tgtattactt tgccatgcca tttgtttcct     3180

ccatgcgtaa cttaatccag actttcacac cttataggaa aaccagtgag tctggagagc     3240

tgcatgggct cacaactgag gaggaatttg tagaagggat atacaaagtg gaaatagaca     3300

ccaaatctta ctggaaggca cttggcatct ccccattcca tgagcatgca gaggtgagta     3360

tacagacctt cgagggttgt tttggttttg gtttttgctt ttggcattcc aggaaatgca     3420

cagttttact cagtgtacca cagaaatgtc ctaaggaagg tgatgaatga ccaaaggttc     3480

cctttcctat tatacaagaa aaaattcaca acactctgag aagcaaattt ctttttgact     3540

ttgatgaaaa tccacttagt aacatgactt gaacttacat gaaactactc atagtctatt     3600

cattccactt tatatgaata ttgatgtatc tgctgttgaa ataatagttt atgaggcagc     3660

cctccagacc ccacgtagag tgtatgtaac aagagatgca ccattttatt tctcgaaaac     3720

ccgtaacatt cttcattcca aaacacatct ggcttctcgg aggtctggac aagtgattct     3780

tggcaacaca tacctataga gacaataaaa tcaaagtaat aatggcaaca caatagataa     3840

catttaccaa gcatacacca tgtggcagac acaattataa gtgttttcca tatttaacct     3900

acttaatcct caggaataag ccactgaggt cagtcctatt attatcccca tcttatagat     3960

gaagaaaatg aggcaccagg aagtcaaata acttgtcaaa ggtcacaaga ctaggaaata     4020

cacaagtaga aatgtttaca attaaggccc aggctgggtt tgccctcagt tctgctatgc     4080

ctcgcattat gccccaggaa actttttccc ttgtgaaagc caagcttaaa aaaagaaaag     4140

ccacatttgt aacgtgctct gttcccctgc ctatggtgag gatcttcaaa cagttataca     4200

tggacccagt ccccctgcct tctccttaat ttcttaagtc atttgaaaca gatggctgtc     4260

atggaaatag aatccagaca tgttggtcag agttaaagat caactaattc catcaaaaat     4320

agctcggcat gaaagggaac tattctctgg cttagtcatg gatgagactt tcaattgcta     4380

taaagtggtt cctttattag acaatgttac cagggaaaca acaggggttt gtttgacttc     4440

tggggcccac aagtcaacaa gagagcccca tctaccaagg agcatgtccc tgactacccc     4500

tcagccagca gcaagacatg gaccccagtc agggcaggag cagggtttcg gcggcgccca     4560

gcacaagaca ttgcccctag agtctcagcc cctaccctcg agtaatagat ctgcctacct     4620

gagactgttg tttgcccaag agctgggtct cagcctgatg ggaaccatat aaaaaggttc     4680

actgacatac tgcccacatg ttgttctctt tcattagatc ttagcttcct tgtctgctct     4740

tcattcttgc agtattcatt caacaaacat taaaaaaaaa aaaaagcatt ctatgtgtgg     4800

aacactctgc tagatgctgt ggatttagaa atgaaaatac atcccgaccc ttggaatgga     4860

agggaaagga ctgaagtaag acagattaag caggaccgtc agcccagctt gaagcccaga     4920

taaatacgga gaacaagaga gagcgagtag tgagagatga gtcccaatgc ctcactttgg     4980

tgacgggtgc gtggtgggct tcatgcagct tcttctgata aatgcctcct tcagaactgg     5040

tcaactctac cttggccagt gacccaggtg gtcatagtag atttaccaag ggaaaatgga     5100

aacttttatt aggagctctt aggcctcttc acttcatgga tttttttttc cttttttttt     5160

gagatggagt tttgccctgt cacccaggct ggaatgcagt ggtgcaatct cagctcactg     5220

caacctccgc ctcccaggtt caagcaattc tcctgcctca gcctcccgag tagctgggac     5280

tacaggtgtg cgccaccaca ccaggctaat ttttgtattt tttgtaaaga caggttttca     5340

ccacgttggc caggctggtc tgaactccag acctcaggtg attcacctgt ctcagcctcc     5400

caaagtgctg ggattacagg tgtgagccac cgtgcccggc tacttcatgg atttttgatt     5460

acagattatg cctcttacaa tttttaagaa gaatcaagtg ggctgaaggt caatgtcacc     5520

ataagacaaa agacattttt attagttgat tctagggaat tggccttaag gggagccctt     5580

tcttcctaag agattcttag gtgattctca cttcctcttg ccccagtatt atttttgttt     5640

ttggtatggc tcactcagat ccttttttcc tcctatccct aagtaatccg ggtttctttt     5700

tcccatattt agaacaaaat gtatttatgc agagtgtgtc caaacctcaa cccaaggcct     5760

gtatacaaaa taaatcaaat taaacacatc tttactgtct tctacctctt tcctgacctc     5820

aatatatccc aacttgcctc actctgagaa ccaaggctgt cccagcacct gagtcgcaga     5880

tattctactg atttgacaga actgtgtgac tatctggaac agcattttga tccacaattt     5940

gcccagttac aaagcttaaa tgagctctag tgcatgcata tatatttcaa aattccacca     6000

tgatcttcca cactctgtat tgtaaataga gccctgtaat gcttttactt cgtatttcat     6060

tgcttgttat acataaaaat atacttttct tcttcatgtt agaaaatgca aagaatagga     6120

gggtggggga atctctgggc ttggagacag gagacttgcc ttcctactat ggttccatca     6180

gaatgtagac tgggacaata caataattca agtctggttt gctcatctgt aaattgggaa     6240

gaatgtttcc agctccagaa tgctaaatct ctaagtctgt ggttggcagc cactattgca     6300

gcagctcttc aatgactcaa tgcagttttg cattctccct accttttttt tctaaaacca     6360

ataaaataga tacagccttt aggctttctg ggatttccct tagtcaagct agggtcatcc     6420

tgactttcgg cgtgaatttg caaaacaaga cctgactctg tactcctgct ctaaggactg     6480

tgcatggttc caaaggctta gcttgccagc atatttgagc tttttccttc tgttcaaact     6540

gttccaaaat ataaaagaat aaaattaatt aagttggcac tggacttccg gtggtcagtc     6600

atgtgtgtca tctgtcacgt ttttcgggct ctggtggaaa tggatctgtc tgtcttctct     6660

cataggtggt attcacagcc aacgactccg gcccccgccg ctacaccatt gccgccctgc     6720

tgagccccta ctcctattcc accacggctg tcgtcaccaa tcccaaggaa tgagggactt     6780

ctcctccagt ggacctgaag gacgagggat gggatttcat gtaaccaaga gtattccatt     6840

tttactaaag cagtgttttc acctcatatg ctatgttaga agtccaggca gagacaataa     6900

aacattcctg tgaaaggcac ttttcattcc actttaactt gattttttaa attcccttat     6960

tgtcccttcc aaaaaaaaga gaatcaaaat tttacaaaga atcaaaggaa ttctagaaag     7020

tatctgggca gaacgctagg agagatccaa atttccattg tcttgcaagc aaagcacgta     7080

ttaaatatga tctgcagcca ttaaaaagac acattctgta aatgagagag ccttattttc     7140

ctgtaacctt cagcaaatag caaaagacac attccaaggg cccacttctt tactgtgggc     7200

a                                                                     7201


<210>  19
<211>  6208
<212>  DNA
<213>  Homo sapiens

<400>  19
ggcaccggtg aatccaagtg tcctctgatg gtcaaagttc tagatgctgt ccgaggcagt       60

cctgccatca atgtggccgt gcatgtgttc agaaaggctg ctgatgacac ctgggagcca      120

tttgcctctg ggtaagttgc caaagaaccc tcccacagga cttggtttta tcttcccgtt      180

tgcccctcac ttggtagaga gaggctcaca tcatctgcta aagaatttac aagtagattg      240

aaaaacgtag gcagaggtca agtatgccct ctgaaggatg ccctcttttt gttttgctta      300

gctaggaagt gaccaggaac ctgagcatca tttaggggca gacagtagag aaaagaagga      360

atcagaactc ctctcctcta gctgtggttt gcaacccttt tgggtcacag aacactttat      420

gtaggtgatg aaaagtaaac attctatgcc cagaaaaaat gcacagatac acacacatac      480

aaaatcatat atgtgatttt aggagtttca cagattccct ggtgtccctg ggtaacacca      540

aagctaagtg tccttgtctt agaattttag gaaaaggtat aatgtgtatt aacccattaa      600

caaaaggaaa ggaattcaga aatattatta accaggcatc tgtctgtagt taatatggat      660

cacccaaaac ccaaggcttt tgcctaatga acactttggg gcacctactg tgtgcaaggc      720

tgggggctgt caagctcagt taaaaaaaaa aagatagaag agatggatcc atgaggcaaa      780

gtacagcccc aggctaatcc cacgatcacc cgacttcatg tccaagagtg gcttctcacc      840

ttcattagcc agttcacaat tttcatggag tttttctacc tgcactagca aaaacttcaa      900

ggaaaataca tattaataaa tctaagcaaa gtgaccagaa gacagagcaa tcaggagacc      960

ctttgcatcc agcagaagag gaactgctaa gtatttacat ctccacagag aagaatttct     1020

gttgggtttt aattgaaccc caagaaccac atgattcttc aaccattatt gggaagatca     1080

ttttcttagg tctggtttta actggctttt tatttgggaa ttcatttatg tttatataaa     1140

atgccaagca taacatgaaa agtggttaca ggactattct aagggagaga cagaatggac     1200

accaaaaata ttccaatgtt cttgtgaatc ttttccttgc accaggacaa aaaaaaaaag     1260

aagtgaaaag aagaaaggag gaggggcata atcagagtca gtaaagacaa ctgctatttt     1320

tatctatcgt agctgttgca gtcaaatggg aagcaatttc caacattcaa ctatggagct     1380

ggtacttaca tggaaataga agttgcctag tgtttgttgc tggcaaagag ttatcagaga     1440

ggttaaatat ataaaaggga aaagagtcag atacaggttc ttcttcctac tttaggtttt     1500

ccactgtgtg tgcaaatgat actccctggt ggtgtgcaga tgcctcaaag ctatcctcac     1560

accacaaggg agaggagcga gatcctgctg tcctggagaa gtgcagagtt agaacagctg     1620

tggccacttg catccaatca tcaatcttga atcacaggga ctctttctta agtaaacatt     1680

atacctggcc gggcacggtg gctcacgcct gtaatcccag cactttggga tgccaaagtg     1740

ggcatatcat ctgaggtcag gagttcaaga ccagcctggc caacatggca aaactccgtc     1800

tttatgaaaa atacaaaaat tagccaggca tggtggcagg cgcctgtaat cccagctaat     1860

tgggaggctg aggctggaga atcccttgaa tctaggaggc agaggttgca gtgagctgag     1920

atcgtgccat tgcactccag cctgggtgac aagagtaaaa ctctgtctca aaaaaaaaaa     1980

attataccta cattctcttc ttatcagaga aaaaaatcta cagtgagctt ttcaaaaagt     2040

ttttacaaac tttttgccat ttaatttcag ttaggagttt tccctacttc tgacttagtt     2100

gaggggaaat gttcataaca tgtttataac atgtttatgt gtgttagttg gtgggggtgt     2160

attactttgc catgccattt gtttcctcca tgcgtaactt aatccagact ttcacacctt     2220

ataggaaaac cagtgagtct ggagagctgc atgggctcac aactgaggag gaatttgtag     2280

aagggatata caaagtggaa atagacacca aatcttactg gaaggcactt ggcatctccc     2340

cattccatga gcatgcagag gtgagtatac agaccttcga gggttgtttt ggttttggtt     2400

tttgcttttg gcattccagg aaatgcacag ttttactcag tgtaccacag aaatgtccta     2460

aggaaggtga tgaatgacca aaggttccct ttcctattat acaagaaaaa attcacaaca     2520

ctctgagaag caaatttctt tttgactttg atgaaaatcc acttagtaac atgacttgaa     2580

cttacatgaa actactcata gtctattcat tccactttat atgaatattg atgtatctgc     2640

tgttgaaata atagtttatg aggcagccct ccagacccca cgtagagtgt atgtaacaag     2700

agatgcacca ttttatttct cgaaaacccg taacattctt cattccaaaa cacatctggc     2760

ttctcggagg tctggacaag tgattcttgg caacacatac ctatagagac aataaaatca     2820

aagtaataat ggcaacacaa tagataacat ttaccaagca tacaccatgt ggcagacaca     2880

attataagtg ttttccatat ttaacctact taatcctcag gaataagcca ctgaggtcag     2940

tcctattatt atccccatct tatagatgaa gaaaatgagg caccaggaag tcaaataact     3000

tgtcaaaggt cacaagacta ggaaatacac aagtagaaat gtttacaatt aaggcccagg     3060

ctgggtttgc cctcagttct gctatgcctc gcattatgcc ccaggaaact ttttcccttg     3120

tgaaagccaa gcttaaaaaa agaaaagcca catttgtaac gtgctctgtt cccctgccta     3180

tggtgaggat cttcaaacag ttatacatgg acccagtccc cctgccttct ccttaatttc     3240

ttaagtcatt tgaaacagat ggctgtcatg gaaatagaat ccagacatgt tggtcagagt     3300

taaagatcaa ctaattccat caaaaatagc tcggcatgaa agggaactat tctctggctt     3360

agtcatggat gagactttca attgctataa agtggttcct ttattagaca atgttaccag     3420

ggaaacaaca ggggtttgtt tgacttctgg ggcccacaag tcaacaagag agccccatct     3480

accaaggagc atgtccctga ctacccctca gccagcagca agacatggac cccagtcagg     3540

gcaggagcag ggtttcggcg gcgcccagca caagacattg cccctagagt ctcagcccct     3600

accctcgagt aatagatctg cctacctgag actgttgttt gcccaagagc tgggtctcag     3660

cctgatggga accatataaa aaggttcact gacatactgc ccacatgttg ttctctttca     3720

ttagatctta gcttccttgt ctgctcttca ttcttgcagt attcattcaa caaacattaa     3780

aaaaaaaaaa aagcattcta tgtgtggaac actctgctag atgctgtgga tttagaaatg     3840

aaaatacatc ccgacccttg gaatggaagg gaaaggactg aagtaagaca gattaagcag     3900

gaccgtcagc ccagcttgaa gcccagataa atacggagaa caagagagag cgagtagtga     3960

gagatgagtc ccaatgcctc actttggtga cgggtgcgtg gtgggcttca tgcagcttct     4020

tctgataaat gcctccttca gaactggtca actctacctt ggccagtgac ccaggtggtc     4080

atagtagatt taccaaggga aaatggaaac ttttattagg agctcttagg cctcttcact     4140

tcatggattt ttttttcctt tttttttgag atggagtttt gccctgtcac ccaggctgga     4200

atgcagtggt gcaatctcag ctcactgcaa cctccgcctc ccaggttcaa gcaattctcc     4260

tgcctcagcc tcccgagtag ctgggactac aggtgtgcgc caccacacca ggctaatttt     4320

tgtatttttt gtaaagacag gttttcacca cgttggccag gctggtctga actccagacc     4380

tcaggtgatt cacctgtctc agcctcccaa agtgctggga ttacaggtgt gagccaccgt     4440

gcccggctac ttcatggatt tttgattaca gattatgcct cttacaattt ttaagaagaa     4500

tcaagtgggc tgaaggtcaa tgtcaccata agacaaaaga catttttatt agttgattct     4560

agggaattgg ccttaagggg agccctttct tcctaagaga ttcttaggtg attctcactt     4620

cctcttgccc cagtattatt tttgtttttg gtatggctca ctcagatcct tttttcctcc     4680

tatccctaag taatccgggt ttctttttcc catatttaga acaaaatgta tttatgcaga     4740

gtgtgtccaa acctcaaccc aaggcctgta tacaaaataa atcaaattaa acacatcttt     4800

actgtcttct acctctttcc tgacctcaat atatcccaac ttgcctcact ctgagaacca     4860

aggctgtccc agcacctgag tcgcagatat tctactgatt tgacagaact gtgtgactat     4920

ctggaacagc attttgatcc acaatttgcc cagttacaaa gcttaaatga gctctagtgc     4980

atgcatatat atttcaaaat tccaccatga tcttccacac tctgtattgt aaatagagcc     5040

ctgtaatgct tttacttcgt atttcattgc ttgttataca taaaaatata cttttcttct     5100

tcatgttaga aaatgcaaag aataggaggg tgggggaatc tctgggcttg gagacaggag     5160

acttgccttc ctactatggt tccatcagaa tgtagactgg gacaatacaa taattcaagt     5220

ctggtttgct catctgtaaa ttgggaagaa tgtttccagc tccagaatgc taaatctcta     5280

agtctgtggt tggcagccac tattgcagca gctcttcaat gactcaatgc agttttgcat     5340

tctccctacc ttttttttct aaaaccaata aaatagatac agcctttagg ctttctggga     5400

tttcccttag tcaagctagg gtcatcctga ctttcggcgt gaatttgcaa aacaagacct     5460

gactctgtac tcctgctcta aggactgtgc atggttccaa aggcttagct tgccagcata     5520

tttgagcttt ttccttctgt tcaaactgtt ccaaaatata aaagaataaa attaattaag     5580

ttggcactgg acttccggtg gtcagtcatg tgtgtcatct gtcacgtttt tcgggctctg     5640

gtggaaatgg atctgtctgt cttctctcat aggtggtatt cacagccaac gactccggcc     5700

cccgccgcta caccattgcc gccctgctga gcccctactc ctattccacc acggctgtcg     5760

tcaccaatcc caaggaatga gggacttctc ctccagtgga cctgaaggac gagggatggg     5820

atttcatgta accaagagta ttccattttt actaaagcag tgttttcacc tcatatgcta     5880

tgttagaagt ccaggcagag acaataaaac attcctgtga aaggcacttt tcattccact     5940

ttaacttgat tttttaaatt cccttattgt cccttccaaa aaaaagagaa tcaaaatttt     6000

acaaagaatc aaaggaattc tagaaagtat ctgggcagaa cgctaggaga gatccaaatt     6060

tccattgtct tgcaagcaaa gcacgtatta aatatgatct gcagccatta aaaagacaca     6120

ttctgtaaat gagagagcct tattttcctg taaccttcag caaatagcaa aagacacatt     6180

ccaagggccc acttctttac tgtgggca                                        6208


<210>  20
<211>  8300
<212>  DNA
<213>  Mus musculus

<400>  20
atggcttccc ttcgactctt cctcctttgc ctcgctggac tggtatttgt gtctgaagct       60

ggccccgcgg tgagtgatcc tgtgagcgat ccagacatgg cagttagacc ttagataaag      120

aagaagtgcc ttcttccaga tgtgagaact agagtactca gactctatat ttaccattag      180

actccaaaga gaagagctgg agtgcctctg gctcttcctt ctattgcttt agcgcattgg      240

gtctgtagtg ctcagtctct ggtgtcctta gataataaag atatgagatt aacatagaaa      300

taaagatata aaagggctgg atgtatagtt tagtggtcca gtgtatgcct agtatgtgaa      360

aagccttctg ttcaacctct agcaatagaa aaacaagata tattctcggt ggggctgtta      420

atattgaatt ctcataaaat ctttaatata tttagtatgc ctattatgtt gttatatttt      480

agttctttag ctaatcaaaa tgcattattg atctttcttt gtcttttttt ggccaacact      540

ctattccagt ctttgaaaaa gtcctttaaa agagttaatc agtataatta aatgagtcag      600

gaagtatgtg agggttattt tacaaccaga gggaattact atagcaacag ctgattagaa      660

tgatctcaag aaaaagccca ttctgtcttt ttgcaccatg cacctttcag tggctccatt      720

cagatggaga ggcaaacaga gcaatggctc tcagagggcc tattttccct ttgaacattc      780

attatccata tccctggtgc acagcagtgc atctgggggc agaaactgtt cttgctttgg      840

aaacaatgct gtctatgtca tactggataa agaagctcat taattgtcaa cacttatgtt      900

atcataatgg gatcagcatg tacttttggt tttgttccag agtctatcac cggaaagaac      960

aagccggttt actctgaccc atttcactga catttctctt gtctcctctg tgcccagggt     1020

gctggagaat ccaaatgtcc tctgatggtc aaagtcctgg atgctgtccg aggcagccct     1080

gctgtagacg tggctgtaaa agtgttcaaa aagacctctg agggatcctg ggagcccttt     1140

gcctctgggt aagcttgtag aaagcccacc atgggaccgg ttccaggttc ccatttgctc     1200

ttattcgtgt tagattcaga cacacacaac ttaccagcta gagggctcag agagagggct     1260

caggggcgaa gggcacgtat tgctcttgta agagacacag gtttaattcc tagcaccaga     1320

atggcagctc ataaccatct gaaactcaca gtcttaggag atctgggtat ctgacattct     1380

cttctaccca ccatgtgtgt ggtgcacaaa ttcacatgca ggcatcaaat cttataaaca     1440

acaacaaaaa accaacaaac ctggtagcaa aagaagatta gaaggttaaa catatgagcc     1500

gagagctttt gttttgtttt gttttgtttt gttttgttta catttcaaat gttatcccct     1560

ttctcggtcc ccctccccaa accctctacc ccattctctc ctccccttct tctatgaggg     1620

tgttccccac caacccactc ccaccttcct gctctcgaat tcccctatac tgggacatca     1680

agccttcaca gaatcaaggg cctctcctcc cattgatgcc cgacaatgtc atcctctgct     1740

acctatgtgg ctggagccat gggtcccttc atgtatcctc cttggttggt ggtttagtct     1800

ctgggaggtc tgggggatct ggttgattga tattattgtt cttcctatga gattgcaaac     1860

cccttcagct ccttcggtcc tttaactcct ccactgggga ccccgagctc agtccaatgg     1920

ttggctgtga gcatccacca gcagaggcct tttttttttt ttttaacaaa gctgctttat     1980

tatgttgctt agagcatgac caggaaccag agcacagtcc aagactgaag ggaggaaaag     2040

ggggggagtc aataacccca ctgtttcata gtggtttgca acccttttat atcacagccc     2100

actttaggca aataatgaaa attatagtct ccagggacag agaagatggt gcaggaagtg     2160

aagtgcctgc tcagaaaatg ggggcttgaa tgtgagttcc cagactctgt gtaagatgcc     2220

cagcatcgaa gtgcatgctt ataacaccag cctggaggta gaagcttaga aacaggggta     2280

ccctgaagtt gcttgttcac cagtgtccct gaatgggtag gtgcatgttt ggtgagagac     2340

cctgtctcaa aaatcaaggt gtaggataat tgaaaatacc tagctttgag cttagatcat     2400

gcaaatgtgt acacacactc acacacacca cacacacaaa aaaatgcaga gacagagaga     2460

tacagagaga cagagagata cagagacaga gacagagaga aaaggagaaa gtaaaaaaca     2520

aataatttaa agacccatgg ccacaaagag gctcaaagac aagcacgtat aaaaccatac     2580

acatgtaatt ttaggagttt tcagattccc tggtacccgt gggtgatgca caagctttga     2640

atcccagtct taaaatctta cgaagaacgt gttcgtgtgt gctaatttat tgatgagagg     2700

aaaggaattg acaaagtgcc cttccggagc ttcctgcatt acccagactc agggtttttt     2760

taaatgtaca ctcagaacag agtagctctg tgcaagggta gcaaccacga agcttaataa     2820

gaaacatatc gtgagagatc tgcaaggcaa atctaggggc tgaccaatct cacagtcacc     2880

cactagcatg tcaacacaac ttcccacctg tgctagccac ttagcaattt tgtgttgttc     2940

tgttttgttt ttgtttttaa caaagcaatt tcaaagagat ttctaattca tctaaacaaa     3000

caaaccaaaa ggaaaacagc aaagacgccc tgagcactta gcagagcagc tatgcagtta     3060

tgactcctgg gtggagactt tatatcaggc ttcaactgaa tacctagaac ctactagtgc     3120

tcttcatcaa tccttgggaa ggtcattttc ttttggtgct gttttgagtt tctatttgtt     3180

aatgtcttca taattataca cgtgttgagc acagcatgca aagtgattag gggaatctag     3240

ttggagtgga atggataccc aaatattcag actttcttgt gactcttctt tcttgtaccc     3300

acatcaaaaa aaaaaaaaat ggagatgaga catggtcaga gtcactaaaa ccagctgcta     3360

cttttaatta cgtggggagc agtttctaac attgccatta ttgaactgat gctgcctggg     3420

tggaaatgga aatcacttag tatttcttgt tggcaaagaa ttactgaatg gattaaattt     3480

ccaaagggag aagtcagtta caagtctttt ctttgtttat taggctttct gctatgataa     3540

attacactac ttccagaagt tacccttagg ccatgggaca ctggactatc actctgctgt     3600

cacaagagat tacagagtta gtcaaggcag cttgtgacac cttcagggac tgtcataaac     3660

ttccagcaag tcattaatcc tgaatgcaat actgtgtgtg tgtgtctatg tgtgtttgta     3720

tgtctgtgtg tgtcttatgt ctgtgtctct gtgtgtgtgt gtgtttgtgt gtgtgtgtgt     3780

atgtatgcct gtgtgtgtct tatgtctgtg tttgtgtgtc tgtgtgtgtc ttatgtctgt     3840

gtttgtatgt ctgtgtgtgt ctgtgtgtgt cttatgtctg tgtctctgtg tgtgtgtgtg     3900

tgtatgtatg tatgtatgta tgtatgtgta tgtgtttgca tctctctgtg tgtctgcgct     3960

tatatatttg tgtatgtgtt tatgtgttcg cctttgtgcg ttgttgggga ttgaatccag     4020

gggaatacaa atgttaagaa agaacgttac cactaagctt cacctgtagg ccttaaagct     4080

tttctttctt ttaaaaattg taattaattc attttcagtc aggatctcca cacctcgtcc     4140

ctgctgctct agaactcact atttaaacac aatcgccctc aaacctgcag caaccctccc     4200

gcctctaccc tgcgagcact agaataataa caggtgaccc cacacgccta gattaagacc     4260

tttaaggtaa acattttact atattttagt ctcataagac aagatgctac aataaagctg     4320

tacataaagt tccctcgaat ttcttgctat tttaactcaa acataaggat ttcctccttt     4380

ttgattcagg taacagaaaa aatacacagg tacatacatg tacacacatg aacacacacg     4440

catcacaacc acatatgcgc acgcttgtgt gatctatcat ttaccatgcc actgaactct     4500

tctttcccca taaattcctc tggacttgtg tgccctccag gaagaccgcg gagtctggag     4560

agctgcacgg gctcaccaca gatgagaagt ttgtagaagg agtgtacaga gtagaactgg     4620

acaccaaatc gtactggaag acacttggca tttccccgtt ccatgaattc gcggatgtaa     4680

gtggacacac caagttgttt ggattttgtt tttagtctca ggaaattccc ttcgctcttg     4740

ctgtacgatg ggcatgagtg gaaagtagat tccacagcca gaatccacag tgctgggaaa     4800

gcaagccttc tgaatttttc taaaactcat ttagcaacat ggcctgaacc tgttcacact     4860

gcttatggtc agctaactat atttatgtaa atattcattt ctctgttgag gaaatgttag     4920

tatttgcttt tgaggcaacc tccagatacc atggagggca tgtcatagtc aaagagaggg     4980

ctccctatgg tatttctcta aattctggca tttcctttat tccaaagcac atctagtgtc     5040

cccagaagtt tgggtagaca attcttggca acacagagaa ttacaacatg ttcaaaaccc     5100

aacagcttaa tatctaaatc atcaagcaaa catcacatgg caaagggatt tctgaatcaa     5160

aactgtttca tccttatgat caacctatgg aggtctagcc tcgacttaca cccattttac     5220

caataagcta agagaagcta agttcctcat caaggacaca aggctagcat gtgtgagcaa     5280

gtgacagagt tgccctctat gttggttagt gtgccttagc cagtgtctca gtaagaaatg     5340

gagctaaatc aaaacccaag gccaacagcc aaaggcacat gagtaacctt tgcttggcac     5400

tgggctcagt ttccctggct cctctcagtc ctcagttcac agaggcagct gtcatgcaaa     5460

tagaatccaa gcttgttggt cagacctgga gataacaaat tccatcaaaa atagctcctc     5520

atgtgaccta gtttgctgtc tgttgctatg atacacacca tgaccgaaaa gcaaccctgg     5580

ggagagaagg gtttatttca tcttacagct tacagttcac catggaggaa agccaggtgg     5640

gaacctggaa gtggaaattg aagcagagac cagaaaggaa tgctgtttac tggctggctt     5700

agctcctttt cttatacagc ttaggtctat gtgcccaggg gatggtactg ccgagcatag     5760

gctgagcccg cctacatcaa ccattagtca aaaaaaggtc catagacttg cctacaggcc     5820

aatctcatgg aggcaatacc ccagtggagg gtccctcttc gcaggttact ctagtttgtg     5880

tcaagttgac aaaacctaac cacaaagcac aaacagggtc tgcccttgtg gcttagccat     5940

ggatgacact ctcagatgat ggtgttacca gacaaaccag aggggctcac caagagtctg     6000

ccacctacca aggtagtact ctactcctca ctgggcacca acacccatat tagctgggcc     6060

agtacaggac ccttgctgtt tcctgcatga attgtccata gaccctgggt ctcagcctgc     6120

cgggagtacc tgtaagtagt cgcctcaaac acattattcc tgttggaaga cttgtctgat     6180

tctcttttag aactcaatca acaaacgttt ttattttgtt ttggcttttt ggagacaaga     6240

tctctcatag gccagcctga cttgaatgta gctgaggatg acctgtgctg ctaatcttct     6300

cgcctcttcc tcccaagtgg taggataata ggcataagac accacagcag ttttactcca     6360

taccagggct ctgaacccag actttaaaca ctctatcaac tgattcacat tcccacccca     6420

tcattcaaca aacatttgaa aaataaaacc cttctgcctt gagcactctg ctaaatacag     6480

cctttgagtg cggagtattt cctcacaacc agggtccaag atgaccccat catacatacc     6540

acggaaaatt aggagatgtt tttaggtctc tttgcttggg gtaattttta tgtgtgtgtg     6600

tacacagccc tgtgcgtgtg tgtgtgtgtg tgtgtgtgtg tgtacaggca cacacgtgta     6660

tgcatgtaga ggctacataa aaaccttagg tgtcattctc aggcactctg ttcacccctt     6720

cacacagccc gaacacacaa aatttgaggc attagcctgg agctcaccag ttaggctaga     6780

ctgacttgcc agcagacccc aggctgtctc catctcccca gctctgggat tacaaactct     6840

atcataccag acatttttat acatattctg agcataaaat tcatgtcttc aggctaacaa     6900

gtcaagagct taaatgactg agctctctta cgtggtggat tttttttaaa actacataat     6960

atcttttttt tttttttcac ttctggggaa gaaacaaatg agcctgagtg acaatgcgac     7020

agaaaagaaa ttttgaggag tgtgtgtgtc tgtgtgtgtg gtggcacatg cctctcatct     7080

aatgctagag gctacagtag aatgctcctg aattagtggc cagccaaggc caagggctag     7140

ggttgtaact cagtggcaga gggcttgcct agcattcgca ggatttgatc catagcgcta     7200

taaataataa taaataaata caacagtcta agatgattct ccctttcatt tatctggatg     7260

ttatttttgt gttagtttta ctctgtcatc caatcattgt ttgccctata tttggacatt     7320

taaaaaaaat ctttattcca agtgtgttca aagctgtatc caaaacctgt ccaccaaatg     7380

agtccaatga catacatctt ctatattacc atctgttcca gatttggctg actcccggca     7440

cctgggctgt tgctgcaccc atgtctcaga tagtctagtg atttgagaag tgactagtaa     7500

ttgcaaaatc cagactttgt ccagaaactt ctatgagctc caaaactttc atttacattt     7560

ctgccagcca caaaccgctt gtgttgtgga gagaaccctg tgatgtcttc ccacagcatc     7620

tcagccttgt ttcttccctt aaaatattca tcttttcaca ttagaacatg caaagggaca     7680

gtgggagcga aacccctgga ctgggacgca cgaagccttc ctttctggtc aggctctcac     7740

tgtagaaact taggccggtt tcagcatgca gtctgctgga gaatggctcc tgccaacatt     7800

ccaggtctgg aagtttgtag tggagttgtt gataaccact gttcgccaca ggtcttttgt     7860

ttgtgggtgt cagtgtttct actctcctga cttttatctg aacccaagaa agggaacaat     7920

agccttcaag ctctctgtga ctctgatctg accagggcca cccacactgc agaaggaaac     7980

ttgcaaagag agacctgcaa ttctctaaga gctccacaca gctccaaaga cttaggcagc     8040

atattttaat ctaattattc gtcccccaac cccaccccag aggacagtta gacaataaaa     8100

ggaagattac cagcttagca tcctgtgaac actttgtctg cagctcctac ctctgggctc     8160

tgttagaact agctgtctct cctctctcct aggtggtttt cacagccaac gactctggcc     8220

atcgccacta caccatcgca gccctgctca gcccatactc ctacagcacc acggctgtcg     8280

tcagcaaccc ccagaattga                                                 8300


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
cacagacaat cagacgtacc agta                                              24


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
ccagctttgc cagtttacga                                                   20


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
ttggacggtt gccctctt                                                     18


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
gatggcttcc cttcgactct tc                                                22


<210>  25
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
cactgacatt tctcttgtct cctct                                             25


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gggctcacca cagatgagaa g                                                 21


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
cactgttcgc cacaggtctt                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
gctcagccca tactcctaca                                                   20


<210>  29
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
gcccaggagg accaggat                                                     18


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
ggcaacttgc ttgaggaaga                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gcagcaaccc agcttcactt                                                   20


<210>  32
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
actgagctgg gacttgaac                                                    19


<210>  33
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
tgcctcactc tgagaacca                                                    19


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34
ggtggagagg ctattcggc                                                    19


<210>  35
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
ggccgtgcat gtgttcag                                                     18


<210>  36
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36
ggttcccatt tgctcttatt cgt                                               23


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
cccacactgc agaaggaaac ttg                                               23


<210>  38
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38
ggttcccatt tgctcttatt cgt                                               23


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
ccagcttagc atcctgtgaa ca                                                22


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40
ggcaacttgc ttgaggaaga                                                   20


<210>  41
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
tgtggagttc agtagtgtgg ag                                                22


<210>  42
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
cactgacatt tctcttgtct cctct                                             25


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
gggacatctc ggtttcctga ctt                                               23


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44
tccacactac tgaactccac aa                                                22


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
cggaacactc gctctacgaa a                                                 21


<210>  46
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46
gggccagctt cagacaca                                                     18


<210>  47
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
cccagggtgc tggagaatcc aa                                                22


<210>  48
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48
gccaagtgtc ttccagtacg at                                                22


<210>  49
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
gttccctttc ttgggttcag a                                                 21


<210>  50
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50
gatgctactg ctttggcaag atc                                               23


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
cctgagctgc taacacggtt                                                   20


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52
agctacagac catgcttagt gta                                               23


<210>  53
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
tgccagttta ggaggaatat gttc                                              24


<210>  54
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54
ctgaggaaac agaggtacca gatat                                             25


<210>  55
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55
agtcacacag ttctgtcaaa tcag                                              24


<210>  56
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56
gaacacggcg gcatcag                                                      17


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57
tcctgtggga gggttctttg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58
ccctctctct gagccctcta                                                   20


<210>  59
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59
gctgcctaag tctttggagc t                                                 21


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60
ccctctctct gagccctcta                                                   20


<210>  61
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61
gagaggagag acagctagtt ctaac                                             25


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62
agctacagac catgcttagt gta                                               23


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63
gccctcttca tacaggaatc ac                                                22


<210>  64
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64
cggacagcat ccaggactt                                                    19


<210>  65
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
tcatgtaatc tggcttcaga gtggga                                            26


<210>  66
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66
tgggaggcaa ttcttagttt caatgga                                           27


<210>  67
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
tcccaaaggt gtctgtctgc aca                                               23


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
ctcctttgcc tcgctggact gg                                                22


<210>  69
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
cggacagcat ccaggactt                                                    19


<210>  70
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
agaaggagtg tacagagtag aactggaca                                         29


<210>  71
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
tgtttgtggg tgtcagtgtt tctactc                                           27


<210>  72
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72
caccacggct gtcgtcagca a                                                 21


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
cttgccaaag cagtagcatc cca                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74
aggtcagaaa gcagagtgga cca                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
cccaggcaat tcctaccttc cca                                               23


<210>  76
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  76
tctgagcatt ctacctcatt gctttggt                                          28


<210>  77
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
aggctgtccc agcacctgag tcg                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
tgggcacaac agacaatcgg ctg                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79
aaggctgctg atgacacctg gga                                               23


<210>  80
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80
agattcagac acacacaact taccagc                                           27


<210>  81
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  81
agacctgcaa ttctctaaga gctccaca                                          28


<210>  82
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  82
agattcagac acacacaact taccagc                                           27


<210>  83
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  83
ttgtctgcag ctcctacctc tggg                                              24


<210>  84
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  84
aggtcagaaa gcagagtgga cca                                               23


<210>  85
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  85
ttgacatgtg tgggtgagag attttactg                                         29


<210>  86
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  86
cccagggtgc tggagaatcc aa                                                22


<210>  87
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  87
guuuuagagc uaugcu                                                       16


<210>  88
<211>  67
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  88
agcauagcaa guuaaaauaa ggcuaguccg uuaucaacuu gaaaaagugg caccgagucg       60

gugcuuu                                                                 67


<210>  89
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  89
guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc cguuaucaac uugaaaaagu       60

ggcaccgagu cggugcu                                                      77


<210>  90
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  90
atggcttctc atcgtctgct cctcctctgc cttgctggac tggtatttgt gtctgaggct       60

ggccctacgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc      120

cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc      180

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      240

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      300

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      360

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      420

gtcgtcacca atcccaagga atga                                             444


<210>  91
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  91
atggcttccc ttcgactctt cctcctttgc ctcgctggac tggtatttgt gtctgaagct       60

ggccccgcgg gcaccggtga atccaagtgt cctctgatgg tcaaagttct agatgctgtc      120

cgaggcagtc ctgccatcaa tgtggccgtg catgtgttca gaaaggctgc tgatgacacc      180

tgggagccat ttgcctctgg gaaaaccagt gagtctggag agctgcatgg gctcacaact      240

gaggaggaat ttgtagaagg gatatacaaa gtggaaatag acaccaaatc ttactggaag      300

gcacttggca tctccccatt ccatgagcat gcagaggtgg tattcacagc caacgactcc      360

ggcccccgcc gctacaccat tgccgccctg ctgagcccct actcctattc caccacggct      420

gtcgtcacca atcccaagga atga                                             444


<210>  92
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  92
atggcttccc ttcgactctt cctcctttgc ctcgctggac tggtatttgt gtctgaagct       60

ggccccgcgg gtgctggaga atccaaatgt cctctgatgg tcaaagtcct ggatgctgtc      120

cgaggcagcc ctgctgtaga cgtggctgta aaagtgttca aaaagacctc tgagggatcc      180

tgggagccct ttgcctctgg gaagaccgcg gagtctggag agctgcacgg gctcaccaca      240

gatgagaagt ttgtagaagg agtgtacaga gtagaactgg acaccaaatc gtactggaag      300

acacttggca tttccccgtt ccatgaattc gcggatgtgg ttttcacagc caacgactct      360

ggccatcgcc actacaccat cgcagccctg ctcagcccat actcctacag caccacggct      420

gtcgtcagca acccccagaa ttga                                             444


<210>  93
<211>  4176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Start Codon

<220>
<221>  misc_feature
<222>  (10)..(30)
<223>  5' NLS

<220>
<221>  misc_feature
<222>  (4126)..(4173)
<223>  3' NLS

<220>
<221>  misc_feature
<222>  (4174)..(4176)
<223>  Stop Codon

<400>  93
atggacaagc ccaagaaaaa gcggaaagtg aagtacagca tcggcctgga catcggcacc       60

aactctgtgg gctgggccgt gatcaccgac gagtacaagg tgcccagcaa gaaattcaag      120

gtgctgggca acaccgacag gcacagcatc aagaagaacc tgatcggcgc cctgctgttc      180

gacagcggcg aaacagccga ggccaccaga ctgaagagaa ccgccagaag aagatacacc      240

aggcggaaga acaggatctg ctatctgcaa gagatcttca gcaacgagat ggccaaggtg      300

gacgacagct tcttccacag actggaagag tccttcctgg tggaagagga caagaagcac      360

gagagacacc ccatcttcgg caacatcgtg gacgaggtgg cctaccacga gaagtacccc      420

accatctacc acctgagaaa gaaactggtg gacagcaccg acaaggccga cctgagactg      480

atctacctgg ccctggccca catgatcaag ttcagaggcc acttcctgat cgagggcgac      540

ctgaaccccg acaacagcga cgtggacaag ctgttcatcc agctggtgca gacctacaac      600

cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg acgccaaggc tatcctgtct      660

gccagactga gcaagagcag aaggctggaa aatctgatcg cccagctgcc cggcgagaag      720

aagaacggcc tgttcggcaa cctgattgcc ctgagcctgg gcctgacccc caacttcaag      780

agcaacttcg acctggccga ggatgccaaa ctgcagctga gcaaggacac ctacgacgac      840

gacctggaca acctgctggc ccagatcggc gaccagtacg ccgacctgtt cctggccgcc      900

aagaacctgt ctgacgccat cctgctgagc gacatcctga gagtgaacac cgagatcacc      960

aaggcccccc tgagcgcctc tatgatcaag agatacgacg agcaccacca ggacctgacc     1020

ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt acaaagaaat cttcttcgac     1080

cagagcaaga acggctacgc cggctacatc gatggcggcg ctagccagga agagttctac     1140

aagttcatca agcccatcct ggaaaagatg gacggcaccg aggaactgct cgtgaagctg     1200

aacagagagg acctgctgag aaagcagaga accttcgaca acggcagcat cccccaccag     1260

atccacctgg gagagctgca cgctatcctg agaaggcagg aagattttta cccattcctg     1320

aaggacaacc gggaaaagat cgagaagatc ctgaccttca ggatccccta ctacgtgggc     1380

cccctggcca gaggcaacag cagattcgcc tggatgacca gaaagagcga ggaaaccatc     1440

accccctgga acttcgagga agtggtggac aagggcgcca gcgcccagag cttcatcgag     1500

agaatgacaa acttcgataa gaacctgccc aacgagaagg tgctgcccaa gcacagcctg     1560

ctgtacgagt acttcaccgt gtacaacgag ctgaccaaag tgaaatacgt gaccgaggga     1620

atgagaaagc ccgccttcct gagcggcgag cagaaaaagg ccatcgtgga cctgctgttc     1680

aagaccaaca gaaaagtgac cgtgaagcag ctgaaagagg actacttcaa gaaaatcgag     1740

tgcttcgact ccgtggaaat ctccggcgtg gaagatagat tcaacgcctc cctgggcaca     1800

taccacgatc tgctgaaaat tatcaaggac aaggacttcc tggataacga agagaacgag     1860

gacattctgg aagatatcgt gctgaccctg acactgtttg aggaccgcga gatgatcgag     1920

gaaaggctga aaacctacgc tcacctgttc gacgacaaag tgatgaagca gctgaagaga     1980

aggcggtaca ccggctgggg caggctgagc agaaagctga tcaacggcat cagagacaag     2040

cagagcggca agacaatcct ggatttcctg aagtccgacg gcttcgccaa ccggaacttc     2100

atgcagctga tccacgacga cagcctgaca ttcaaagagg acatccagaa agcccaggtg     2160

tccggccagg gcgactctct gcacgagcat atcgctaacc tggccggcag ccccgctatc     2220

aagaagggca tcctgcagac agtgaaggtg gtggacgagc tcgtgaaagt gatgggcaga     2280

cacaagcccg agaacatcgt gatcgagatg gctagagaga accagaccac ccagaaggga     2340

cagaagaact cccgcgagag gatgaagaga atcgaagagg gcatcaaaga gctgggcagc     2400

cagatcctga aagaacaccc cgtggaaaac acccagctgc agaacgagaa gctgtacctg     2460

tactacctgc agaatggccg ggatatgtac gtggaccagg aactggacat caacagactg     2520

tccgactacg atgtggacca tatcgtgcct cagagctttc tgaaggacga ctccatcgat     2580

aacaaagtgc tgactcggag cgacaagaac agaggcaaga gcgacaacgt gccctccgaa     2640

gaggtcgtga agaagatgaa gaactactgg cgacagctgc tgaacgccaa gctgattacc     2700

cagaggaagt tcgataacct gaccaaggcc gagagaggcg gcctgagcga gctggataag     2760

gccggcttca tcaagaggca gctggtggaa accagacaga tcacaaagca cgtggcacag     2820

atcctggact cccggatgaa cactaagtac gacgaaaacg ataagctgat ccgggaagtg     2880

aaagtgatca ccctgaagtc caagctggtg tccgatttcc ggaaggattt ccagttttac     2940

aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg cctacctgaa cgccgtcgtg     3000

ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg agttcgtgta cggcgactac     3060

aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc aggaaatcgg caaggctacc     3120

gccaagtact tcttctacag caacatcatg aactttttca agaccgaaat caccctggcc     3180

aacggcgaga tcagaaagcg ccctctgatc gagacaaacg gcgaaaccgg ggagatcgtg     3240

tgggataagg gcagagactt cgccacagtg cgaaaggtgc tgagcatgcc ccaagtgaat     3300

atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca aagagtctat cctgcccaag     3360

aggaacagcg acaagctgat cgccagaaag aaggactggg accccaagaa gtacggcggc     3420

ttcgacagcc ctaccgtggc ctactctgtg ctggtggtgg ctaaggtgga aaagggcaag     3480

tccaagaaac tgaagagtgt gaaagagctg ctggggatca ccatcatgga aagaagcagc     3540

tttgagaaga accctatcga ctttctggaa gccaagggct acaaagaagt gaaaaaggac     3600

ctgatcatca agctgcctaa gtactccctg ttcgagctgg aaaacggcag aaagagaatg     3660

ctggcctctg ccggcgaact gcagaaggga aacgagctgg ccctgcctag caaatatgtg     3720

aacttcctgt acctggcctc ccactatgag aagctgaagg gcagccctga ggacaacgaa     3780

cagaaacagc tgtttgtgga acagcataag cactacctgg acgagatcat cgagcagatc     3840

agcgagttct ccaagagagt gatcctggcc gacgccaatc tggacaaggt gctgtctgcc     3900

tacaacaagc acagggacaa gcctatcaga gagcaggccg agaatatcat ccacctgttc     3960

accctgacaa acctgggcgc tcctgccgcc ttcaagtact ttgacaccac catcgaccgg     4020

aagaggtaca ccagcaccaa agaggtgctg gacgccaccc tgatccacca gagcatcacc     4080

ggcctgtacg agacaagaat cgacctgtct cagctgggag gcgacaagag acctgccgcc     4140

actaagaagg ccggacaggc caaaaagaag aagtga                               4176


<210>  94
<211>  1391
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (4)..(10)
<223>  5' NLS

<220>
<221>  MISC_FEATURE
<222>  (1376)..(1391)
<223>  3' NLS

<400>  94

Met Asp Lys Pro Lys Lys Lys Arg Lys Val Lys Tyr Ser Ile Gly Leu 
1               5                   10                  15      


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
            20                  25                  30          


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
        35                  40                  45              


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
    50                  55                  60                  


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
65                  70                  75                  80  


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
                85                  90                  95      


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
            100                 105                 110         


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
        115                 120                 125             


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
    130                 135                 140                 


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
145                 150                 155                 160 


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
                165                 170                 175     


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
            180                 185                 190         


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
        195                 200                 205             


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
    210                 215                 220                 


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
225                 230                 235                 240 


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
                245                 250                 255     


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
            260                 265                 270         


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
        275                 280                 285             


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
    290                 295                 300                 


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
305                 310                 315                 320 


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
                325                 330                 335     


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
            340                 345                 350         


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
        355                 360                 365             


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
    370                 375                 380                 


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
385                 390                 395                 400 


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
                405                 410                 415     


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
            420                 425                 430         


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
        435                 440                 445             


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
    450                 455                 460                 


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
465                 470                 475                 480 


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
                485                 490                 495     


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
            500                 505                 510         


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
        515                 520                 525             


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
    530                 535                 540                 


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
545                 550                 555                 560 


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
                565                 570                 575     


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
            580                 585                 590         


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
        595                 600                 605             


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
    610                 615                 620                 


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
625                 630                 635                 640 


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
                645                 650                 655     


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
            660                 665                 670         


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
        675                 680                 685             


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
    690                 695                 700                 


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
705                 710                 715                 720 


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
                725                 730                 735     


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
            740                 745                 750         


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
        755                 760                 765             


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
    770                 775                 780                 


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
785                 790                 795                 800 


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
                805                 810                 815     


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
            820                 825                 830         


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
        835                 840                 845             


Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu 
    850                 855                 860                 


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
865                 870                 875                 880 


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
                885                 890                 895     


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
            900                 905                 910         


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
        915                 920                 925             


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
    930                 935                 940                 


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
945                 950                 955                 960 


Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp 
                965                 970                 975     


Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His 
            980                 985                 990         


Asp Ala Tyr Leu Asn Ala Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr 
        995                 1000                 1005             


Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr 
    1010                 1015                 1020             


Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys 
    1025                 1030                 1035             


Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe 
    1040                 1045                 1050             


Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro 
    1055                 1060                 1065             


Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys 
    1070                 1075                 1080             


Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val Leu Ser  Met Pro Gln 
    1085                 1090                 1095             


Val Asn  Ile Val Lys Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala 
    1115                 1120                 1125             


Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser 
    1130                 1135                 1140             


Pro Thr  Val Ala Tyr Ser Val  Leu Val Val Ala Lys  Val Glu Lys 
    1145                 1150                 1155             


Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile 
    1160                 1165                 1170             


Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe 
    1175                 1180                 1185             


Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile 
    1190                 1195                 1200             


Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys 
    1205                 1210                 1215             


Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu 
    1220                 1225                 1230             


Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His 
    1235                 1240                 1245             


Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln 
    1250                 1255                 1260             


Leu Phe  Val Glu Gln His Lys  His Tyr Leu Asp Glu  Ile Ile Glu 
    1265                 1270                 1275             


Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn 
    1280                 1285                 1290             


Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro 
    1295                 1300                 1305             


Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr 
    1310                 1315                 1320             


Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile 
    1325                 1330                 1335             


Asp Arg  Lys Arg Tyr Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr 
    1340                 1345                 1350             


Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp 
    1355                 1360                 1365             


Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro Ala Ala  Thr Lys Lys 
    1370                 1375                 1380             


Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1385                 1390     


