                         SEQUENCE LISTING

<110>  VOYAGER THERAPEUTICS, INC.
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
       UNIVERSITE DE STRASBOURG
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  RESCUE OF CENTRAL AND PERIPHERAL NEUROLOGICAL PHENOTYPE OF 
       FRIEDREICH'S ATAXIA BY INTRAVENOUS DELIVERY

<130>  2057.1054PCT

<140>  PCT/US2018/XXXXXX
<141>  2018-09-28

<150>  US 62/565,840
<151>  2017-09-29

<150>  US 62/663,835
<151>  2018-04-27

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  2772
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Polynucleotide

<400>  1
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc       60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca      120

actccatcac taggggttcc ttgtagttaa tgattaaccc gccatgctac ttatctacgt      180

agccatgcgt cgacataacg cgtcgttaca taacttacgg taaatggccc gcctggctga      240

ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca      300

atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca      360

gtacatcaag tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg      420

cccgcctggc attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc      480

tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt      540

ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt      600

ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg      660

acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata taagcagagc tcgggagcaa      720

gcttcgttta gtgaaccgtc agatcgcctg gagacgccat ccacgctgtt ttgacctcca      780

tagaagacac cgggaccgat ccagcctccg cggattcgaa tcccggccgg gaacggtgca      840

ttggaacgcg gattccccgt gccaagagtg acgtaagtac cgcctataga gtctataggc      900

ccacaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt ctaatacttt      960

ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct ttgcaccatt     1020

ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat     1080

atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa     1140

tccagctacc attctgcttt tattttatgg ttgggataag gctggattat tctgagtcca     1200

agctaggccc ttttgctaat catgttcata cctcttatct tcctcccaca gctcctgggc     1260

aacgtgctgg tctgtgtgct ggcccatcac tttggcaaag aattgggatt cgaaccggta     1320

tgtggacttt cgggcgccgc gcagttgccg gcctcctggc gtccccgagc ccggcccagg     1380

cccagaccct cacccgggcc ccgcggctgg cagagttggc ccagctctgc agccgccggg     1440

gcctgcgcac cggcatcaat gcgacctgca caacccacca caccagttcg aacctccgtg     1500

gcctcaacca gattcggaat gtcaaaaggc agagtgtcta cttgatgaat ttgaggaaat     1560

cgggaacttt gggccaccca ggctctctag atgacaccac ctatgaaaga ctagcagagg     1620

aaacgctgga ctctttagca gagttttttg aagaccttgc agacaagcca tacacctttg     1680

aggactatga tgtttccttt gggagtggtg tcttaactgt taaactgggt ggagatctag     1740

gaacctacgt gatcaacaag cagacgccaa acaagcaaat ctggttatct tctccatcca     1800

gtggacccaa gcgttatgac tggactggga aaaactgggt gtattcccac gacggcgttt     1860

ccctccatga gctgctgggc gcagagctca ctaaagcctt aaaaaccaaa ctggacttgt     1920

cttccttggc ctattccgga aaagacgctt atccttatga cgtgcctgac tatgcctgat     1980

gactcgagcc attgactagt acaaacacca ttgtcacact ccacacaaac accattgtca     2040

cactccacac aaacaccatt gtcacactcc actgcagtca ggtctatcct gaggatgggt     2100

ggcatccctg tgacccctcc ccagtgcctc tcctggccct ggaagttgcc actccagtgc     2160

ccaccagcct tgtcctaata aaattaagtt gcatcatttt gtctgactag gtgtccttct     2220

ataatattat ggggtggagg ggggtggtat ggagcaaggg gcaagttggg aagacaacct     2280

gtagggcctg cggggtctat tgggaaccaa gctggagtgc agtggcacaa tcttggctca     2340

ctgcaatctc cgcctcctgg gttcaagcga ttctcctgcc tcagcctccc gagttgttgg     2400

gattccaggc atgcatgacc aggctcagct aatttttgtt tttttggtag agacggggtt     2460

tcaccatatt ggccaggctg gtctccaact cctaatctca ggtgatctac ccaccttggc     2520

ctcccaaatt gctgggatta caggcgtgaa ccactgctcc cttccctgtc cttggcctag     2580

gtatcgatgc tacgtagata agtagcatgg cgggttaatc attaactaca gaggaacccc     2640

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac     2700

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca     2760

gctgcctgca gg                                                         2772


<210>  2
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Polypeptide

<400>  2

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Thr Leu Ala Val 
            580                 585                 590         


Pro Phe Lys Ala Gln Ala Gln Thr Gly Trp Val Gln Asn Gln Gly Ile 
        595                 600                 605             


Leu Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro 
    610                 615                 620                 


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
625                 630                 635                 640 


Leu Met Gly Gly Phe Gly Met Lys His Pro Pro Pro Gln Ile Leu Ile 
                645                 650                 655     


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Ala Phe Asn Lys Asp 
            660                 665                 670         


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
        675                 680                 685             


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
    690                 695                 700                 


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Asn Asn Val Glu Phe 
705                 710                 715                 720 


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
                725                 730                 735     


Arg Tyr Leu Thr Arg Asn Leu 
            740             


<210>  3
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic Polynucleotide

<400>  3
atggctgccg atggttatct tccagattgg ctcgaggaca accttagtga aggaattcgc       60

gagtggtggg ctttgaaacc tggagcccct caacccaagg caaatcaaca acatcaagac      120

aacgctcgag gtcttgtgct tccgggttac aaataccttg gacccggcaa cggactcgac      180

aagggggagc cggtcaacgc agcagacgcg gcggccctcg agcacgacaa ggcctacgac      240

cagcagctca aggccggaga caacccgtac ctcaagtaca accacgccga cgccgagttc      300

caggagcggc tcaaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag      360

gccaaaaaga ggcttcttga acctcttggt ctggttgagg aagcggctaa gacggctcct      420

ggaaagaaga ggcctgtaga gcagtctcct caggaaccgg actcctccgc gggtattggc      480

aaatcgggtg cacagcccgc taaaaagaga ctcaatttcg gtcagactgg cgacacagag      540

tcagtcccag accctcaacc aatcggagaa cctcccgcag ccccctcagg tgtgggatct      600

cttacaatgg cttcaggtgg tggcgcacca gtggcagaca ataacgaagg tgccgatgga      660

gtgggtagtt cctcgggaaa ttggcattgc gattcccaat ggctggggga cagagtcatc      720

accaccagca cccgaacctg ggccctgccc acctacaaca atcacctcta caagcaaatc      780

tccaacagca catctggagg atcttcaaat gacaacgcct acttcggcta cagcaccccc      840

tgggggtatt ttgacttcaa cagattccac tgccacttct caccacgtga ctggcagcga      900

ctcatcaaca acaactgggg attccggcct aagcgactca acttcaagct cttcaacatt      960

caggtcaaag aggttacgga caacaatgga gtcaagacca tcgccaataa ccttaccagc     1020

acggtccagg tcttcacgga ctcagactat cagctcccgt acgtgctcgg gtcggctcac     1080

gagggctgcc tcccgccgtt cccagcggac gttttcatga ttcctcagta cgggtatctg     1140

acgcttaatg atggaagcca ggccgtgggt cgttcgtcct tttactgcct ggaatatttc     1200

ccgtcgcaaa tgctaagaac gggtaacaac ttccagttca gctacgagtt tgagaacgta     1260

cctttccata gcagctacgc tcacagccaa agcctggacc gactaatgaa tccactcatc     1320

gaccaatact tgtactatct ctcaaagact attaacggtt ctggacagaa tcaacaaacg     1380

ctaaaattca gtgtggccgg acccagcaac atggctgtcc agggaagaaa ctacatacct     1440

ggacccagct accgacaaca acgtgtctca accactgtga ctcaaaacaa caacagcgaa     1500

tttgcttggc ctggagcttc ttcttgggct ctcaatggac gtaatagctt gatgaatcct     1560

ggacctgcta tggccagcca caaagaagga gaggaccgtt tctttccttt gtctggatct     1620

ttaatttttg gcaaacaagg aactggaaga gacaacgtgg atgcggacaa agtcatgata     1680

accaacgaag aagaaattaa aactactaac ccggtagcaa cggagtccta tggacaagtg     1740

gccacaaacc accagagtgc ccaaactttg gcggtgcctt ttaaggcaca ggcgcagacc     1800

ggctgggttc aaaaccaagg aatacttccg ggtatggttt ggcaggacag agatgtgtac     1860

ctgcaaggac ccatttgggc caaaattcct cacacggacg gcaactttca cccttctccg     1920

ctgatgggag ggtttggaat gaagcacccg cctcctcaga tcctcatcaa aaacacacct     1980

gtacctgcgg atcctccaac ggccttcaac aaggacaagc tgaactcttt catcacccag     2040

tattctactg gccaagtcag cgtggagatc gagtgggagc tgcagaagga aaacagcaag     2100

cgctggaacc cggagatcca gtacacttcc aactattaca agtctaataa tgttgaattt     2160

gctgttaata ctgaaggtgt atatagtgaa ccccgcccca ttggcaccag atacctgact     2220

cgtaatctgt aa                                                         2232


<210>  4
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  5
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Arg Tyr Val Val Asp Leu Ser Val Met Thr Gly Leu Gly Lys Thr Gly 
                165                 170                 175     


Cys Thr Pro Thr Thr Ala Cys Pro Ser Met Ser Cys Trp Pro Gln Ser 
            180                 185                 190         


Ser Leu Lys Pro 
        195     


<210>  6
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Arg Leu Thr Trp Leu Leu Trp Leu Phe His Pro 
                165                 170     


<210>  7
<211>  7168
<212>  DNA
<213>  Homo sapiens

<400>  7
agtctccctt gggtcagggg tcctggttgc actccgtgct ttgcacaaag caggctctcc       60

atttttgtta aatgcacgaa tagtgctaag ctgggaagtt cttcctgagg tctaacctct      120

agctgctccc ccacagaaga gtgcctgcgg ccagtggcca ccaggggtcg ccgcagcacc      180

cagcgctgga gggcggagcg ggcggcagac ccggagcagc atgtggactc tcgggcgccg      240

cgcagtagcc ggcctcctgg cgtcacccag cccagcccag gcccagaccc tcacccgggt      300

cccgcggccg gcagagttgg ccccactctg cggccgccgt ggcctgcgca ccgacatcga      360

tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt ggcctcaacc agatttggaa      420

tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa tctggaactt tgggccaccc      480

aggctctcta gatgagacca cctatgaaag actagcagag gaaacgctgg actctttagc      540

agagtttttt gaagaccttg cagacaagcc atacacgttt gaggactatg atgtctcctt      600

tgggagtggt gtcttaactg tcaaactggg tggagatcta ggaacctatg tgatcaacaa      660

gcagacgcca aacaagcaaa tctggctatc ttctccatcc agtggaccta agcgttatga      720

ctggactggg aaaaactggg tgtactccca cgacggcgtg tccctccatg agctgctggc      780

cgcagagctc actaaagcct taaaaaccaa actggacttg tcttccttgg cctattccgg      840

aaaagatgct tgatgcccag ccccgtttta aggacattaa aagctatcag gccaagaccc      900

cagcttcatt atgcagctga ggtctgtttt ttgttgttgt tgttgtttat tttttttatt      960

cctgcttttg aggacagttg ggctatgtgt cacagctctg tagaaagaat gtgttgcctc     1020

ctaccttgcc cccaagttct gatttttaat ttctatggaa gattttttgg attgtcggat     1080

ttcctccctc acatgatacc ccttatcttt tataatgtct tatgcctata cctgaatata     1140

acaaccttta aaaaagcaaa ataataagaa ggaaaaattc caggagggaa aatgaattgt     1200

cttcactctt cattctttga aggatttact gcaagaagta catgaagagc agctggtcaa     1260

cctgctcact gttctatctc caaatgagac acattaaagg gtagcctaca aatgttttca     1320

ggcttctttc aaagtgtaag cacttctgag ctctttagca ttgaagtgtc gaaagcaact     1380

cacacgggaa gatcatttct tatttgtgct ctgtgactgc caaggtgtgg cctgcactgg     1440

gttgtccagg gagacctagt gctgtttctc ccacatattc acatacgtgt ctgtgtgtat     1500

atatattttt tcaatttaaa ggttagtatg gaatcagctg ctacaagaat gcaaaaaatc     1560

ttccaaagac aagaaaagag gaaaaaaagc cgttttcatg agctgagtga tgtagcgtaa     1620

caaacaaaat catggagctg aggaggtgcc ttgtaaacat gaaggggcag ataaaggaag     1680

gagatactca tgttgataaa gagagccctg gtcctagaca tagttcagcc acaaagtagt     1740

tgtccctttg tggacaagtt tcccaaattc cctggacctc tgcttcccca tctgttaaat     1800

gagagaatag agtatggttg attcccagca ttcagtggtc ctgtcaagca acctaacagg     1860

ctagttctaa ttccctattg ggtagatgag gggatgacaa agaacagttt ttaagctata     1920

taggaaacat tgttattggt gttgccctat cgtgatttca gttgaattca tgtgaaaata     1980

atagccatcc ttggcctggc gcggtggctc acacctgtaa tcccagcact tttggaggcc     2040

aaggtgggtg gatcacctga ggtcaggagt tcaagaccag cctggccaac atgatgaaac     2100

cccgtctcta ctaaaaatac aaaaaattag ccgggcatga tggcaggtgc ctgtaatccc     2160

agctacttgg gaggctgaag cggaagaatc gcttgaaccc agaggtggag gttgcagtga     2220

gccgagatcg tgccattgca ctgtaacctg ggtgactgag caaaactctg tctcaaaata     2280

ataataacaa tataataata ataatagcca tcctttattg tacccttact gggttaatcg     2340

tattatacca cattacctca ttttaatttt tactgacctg cactttatac aaagcaacaa     2400

gcctccagga cattaaaatt catgcaaagt tatgctcatg ttatattatt ttcttactta     2460

aagaaggatt tattagtggc tgggcatggt ggcgtgcacc tgtaatccca ggtactcagg     2520

aggctgagac gggagaattg cttgacccca ggcggaggag gttacagtga gtcgagatcg     2580

tacctgagcg acagagcgag actccgtctc aaaaaaaaaa aaaaggaggg tttattaatg     2640

agaagtttgt attaatatgt agcaaaggct tttccaatgg gtgaataaaa acacattcca     2700

ttaagtcaag ctgggagcag tggcatatac ctatagtccc agctgcacag gaggctgaga     2760

caggaggatt gcttgaagcc aggaattgga gatcagcctg ggcaacacag caagatccta     2820

tctcttaaaa aaagaaaaaa aaacctatta ataataaaac agtataaaca aaagctaaat     2880

aggtaaaata ttttttctga aataaaatta ttttttgagt ctgatggaaa tgtttaagtg     2940

cagtaggcca gtgccagtga gaaaataaat aacatcatac atgtttgtat gtgtttgcat     3000

cttgcttcta ctgaaagttt cagtgcaccc cacttactta gaactcggtg acatgatgta     3060

ctcctttatc tgggacacag cacaaaagag gtatgcagtg gggctgctct gacatgaaag     3120

tggaagttaa ggaatctggg ctcttatggg gtccttgtgg gccagccctt caggcctatt     3180

ttactttcat tttacatata gctctaattg gtttgattat ctcgttccca aggcagtggg     3240

agatccccat ttaaggaaag aaaaggggcc tggcacagtg gctcatgcct gtaatcccag     3300

cactttggga ggctgaggca agtgtatcac ctgaggtcag gagttcaaga ccagcctggc     3360

caacatggca aaatcccgtc tctactaaaa atattaaaaa attggctggg cgtggtggtt     3420

cgtgcctata atttcagcta ctcaggaggc tgaggcagga gaatcgctgt aacctggggg     3480

gtggaggttg cagtgagacg agatcatgcc acttcactcc agcctggcca acagagccat     3540

actccgtctc aaataaataa ataaataaat aaagggactt caaacacatg aacagcagcc     3600

aggggaagaa tcaaaatcat attctgtcaa gcaaactgga aaagtaccac tgtgtgtacc     3660

aatagcctcc ccaccacaga ccctgggagc atcgcctcat ttatggtgtg gtccagtcat     3720

ccatgtgaag gatgagtttc caggaaaagg ttattaaata ttcactgtaa catactggag     3780

gaggtgagga attgcataat acaatcttag aaaacttttt tttccccttt ctattttttg     3840

agacaggatc tcactttggc actcaggctg gaggacagtg gtacaatcaa agctcatggc     3900

agcctcgacc tccctgggct tgggcaatcc tcccacaggt gtgcacctcc atagctggct     3960

aatttgtgta ttttttgtag agatggggtt tcaccatgtt gcccaggctg gtctctaaca     4020

cttaggctca agtgatccac ctgcctcgtc ctcccaagat gctgggatta caggtgtgtg     4080

ccacaggtgt tcatcagaaa gctttttcta ttatttttac cttcttgagt gggtagaacc     4140

tcagccacat agaaaataaa atgttctggc atgacttatt tagctctctg gaattacaaa     4200

gaaggaatga ggtgtgtaaa agagaacctg ggtttttgaa tcacaaattt agaatttaat     4260

cgaaactctg cctcttactt gtttgtagac actgacagtg gcctcatgtt tttttttttt     4320

ttaatctata aaatggagat atctaacatg ttgagcctgg gcccacaggc aaagcacaat     4380

cctgatgtga gaagtactca gttcatgaca actgttgttc tcacatgcat agcataattt     4440

catattcaca ttggaggact tctcccaaaa tatggatgac gttccctact caaccttgaa     4500

cttaatcaaa atactcagtt tacttaactt cgtattagat tctgattccc tggaaccatt     4560

tatcgtgtgc cttaccatgc ttatatttta cttgatcttt tgcatacctt ctaaaactat     4620

tttagccaat ttaaaatttg acagtttgca ttaaattata ggtttacaat atgctttatc     4680

cagctatacc tgccccaaat tctgacagat gcttttgcca cctctaaagg aagacccatg     4740

ttcatagtga tggagtttgt gtggactaac catgcaaggt tgccaaggaa aaatcgcttt     4800

acgcttccaa ggtacacact aagatgaaag taattttagt ccgtgtccag ttggattctt     4860

ggcacatagt tatcttctgc tagaacaaac taaaacagct acatgccagc aagggagaaa     4920

ggggaaggag gggcaaagtt ttgaaatttc atgtaaattt atgctgttca aaacgacgag     4980

ttcatgactt tgtgtataga gtaagaaatg ccttttcttt tttgagacag agtcttgctc     5040

tgtcacccag gctggagtgc agtggcacga tctgggctca ctacaacctc cgcctcctgg     5100

gttcaagcaa ttctctgcct cagcctcccg agtagctggg attacaggtg cctgccacca     5160

cacccggcta atttttgtat ttttagtaga gacggggttt caccatcatg gccaggctgg     5220

tcttgaactc ctgacctagt aatccacctg cctccgcctc ccaaagtgct gggattacag     5280

gcgtgagcca ctgcacccag ccagaaatgc cttctaatct ttggtttatc ttaattagcc     5340

aggacacttg gagtgcatcc cgaagtacct gatcagtggc ccctttggaa tgtgtaaaac     5400

tcagctcact tatatccctg catccgctac agagacagaa tccaagctca tatgttccat     5460

cttctctggc tgtatagttt aaggaatgga aggcaccaga acagatttat tgaaatgttt     5520

attagctgaa gatttattta gacagttgag gaaaacatca gcacccagca gtaaaattgg     5580

ctctcaaaga ttttcttctc ctgtggaaag tcagacctct gaggccccat ccaggtagaa     5640

gtactagtgc aagaagggcc tctgctgtcc acttgtgttt ctgtgatctg tgggaacatt     5700

gttaacgcca catcttgacc tcaaattgtt tagctcctgg ccagacacgg tggctcacac     5760

ctgtaatccc agcactttga gaggctgagg caggtggatc acctgaggtt aggagttcga     5820

ggccagcctg gtcaacatgg taaaaccccg cctctactaa aaatacaaaa attagctggc     5880

cgtagtggcg cacgcctgtt atcccagcta ctcgggaggc tgaggcagga gaattgcttg     5940

aacctgggtg gtggaggttg cagtgagccg agattacacc actgcactcc agcctgggtg     6000

acaagaggga aactccatta aaaaaatgta attcccgtgt ctgccatctt aagtgtaaag     6060

gtggctaaat tatatagaaa aataagacaa tatcatttcc caattacatt cctttcctac     6120

cgcactctat gatgctagct gagatttttc caaaagaaaa tggcttaaat aaaaccctaa     6180

gagaaagaaa aactttaaat ccctccaaag ctcaaaagta atagaaacag atgagtttgg     6240

agtcaggatt tctctgtaag attgcctagg ctgtgtactg cacatctcca ggtgccactg     6300

ttgacagaga ttataactac aatgtgaagt gaatggtgcc actgacagtt atgcaaaccg     6360

tccagagcat agccacctga tcctgctggg attcctcttg ccagtccatc agcagttccc     6420

cttgaaagtt tcaccaaaca tcccttaaat ctgccctctc ctgcccgtcc ccagtggagg     6480

tcctcatcat ttttcacctg catttttgca ggagctttct tatatccacc ttcctccttt     6540

tctctcagcc catcatctag ctacacagtc tccagggtaa gctttcagaa aggcaatctc     6600

ttgtctgtaa aacctaagca ggaccaaggc caagtttctt agcctgaaaa atgtgctttt     6660

ctgactgaac tgttcaggca ctgactctac atataattat gcttttctac cccctcacac     6720

tcaacacttt gactccagca atcccaaatc cccagatccc taagtgtgct gtgctatttt     6780

cacgtggctc tcagacttgg ccagtgctgt ttccattttg gtctttattc cccacatctc     6840

tgcctggggg gtagattcta ccctgaaaaa tgttcttggc acagccttgc aaactcctcc     6900

tccactcagc ctctgcctgg atgcccttga ttgttccatg tcctcagcat accatgtttg     6960

tctttcccag cactgaccta ccatgtgtca cccctgcttg gctgtacctt ccatgaggct     7020

aggactatgt gtctcctttg ttgactgctg ttgccctagc atcttgcaca gttccttgca     7080

cacaattaga gctctataaa tgtcaaataa atgtgttata attatatgtt taagatagtt     7140

gttcaaataa actctaaata accccaac                                        7168


<210>  8
<211>  7176
<212>  DNA
<213>  Homo sapiens

<400>  8
agtctccctt gggtcagggg tcctggttgc actccgtgct ttgcacaaag caggctctcc       60

atttttgtta aatgcacgaa tagtgctaag ctgggaagtt cttcctgagg tctaacctct      120

agctgctccc ccacagaaga gtgcctgcgg ccagtggcca ccaggggtcg ccgcagcacc      180

cagcgctgga gggcggagcg ggcggcagac ccggagcagc atgtggactc tcgggcgccg      240

cgcagtagcc ggcctcctgg cgtcacccag cccagcccag gcccagaccc tcacccgggt      300

cccgcggccg gcagagttgg ccccactctg cggccgccgt ggcctgcgca ccgacatcga      360

tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt ggcctcaacc agatttggaa      420

tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa tctggaactt tgggccaccc      480

aggctctcta gatgagacca cctatgaaag actagcagag gaaacgctgg actctttagc      540

agagtttttt gaagaccttg cagacaagcc atacacgttt gaggactatg atgtctcctt      600

tgggagtggt gtcttaactg tcaaactggg tggagatcta ggaacctatg tgatcaacaa      660

gcagacgcca aacaagcaaa tctggctatc ttctccatcc aggtatgtag tggacctaag      720

cgttatgact ggactgggaa aaactgggtg tactcccacg acggcgtgtc cctccatgag      780

ctgctggccg cagagctcac taaagcctta aaaaccaaac tggacttgtc ttccttggcc      840

tattccggaa aagatgcttg atgcccagcc ccgttttaag gacattaaaa gctatcaggc      900

caagacccca gcttcattat gcagctgagg tctgtttttt gttgttgttg ttgtttattt      960

tttttattcc tgcttttgag gacagttggg ctatgtgtca cagctctgta gaaagaatgt     1020

gttgcctcct accttgcccc caagttctga tttttaattt ctatggaaga ttttttggat     1080

tgtcggattt cctccctcac atgatacccc ttatctttta taatgtctta tgcctatacc     1140

tgaatataac aacctttaaa aaagcaaaat aataagaagg aaaaattcca ggagggaaaa     1200

tgaattgtct tcactcttca ttctttgaag gatttactgc aagaagtaca tgaagagcag     1260

ctggtcaacc tgctcactgt tctatctcca aatgagacac attaaagggt agcctacaaa     1320

tgttttcagg cttctttcaa agtgtaagca cttctgagct ctttagcatt gaagtgtcga     1380

aagcaactca cacgggaaga tcatttctta tttgtgctct gtgactgcca aggtgtggcc     1440

tgcactgggt tgtccaggga gacctagtgc tgtttctccc acatattcac atacgtgtct     1500

gtgtgtatat atattttttc aatttaaagg ttagtatgga atcagctgct acaagaatgc     1560

aaaaaatctt ccaaagacaa gaaaagagga aaaaaagccg ttttcatgag ctgagtgatg     1620

tagcgtaaca aacaaaatca tggagctgag gaggtgcctt gtaaacatga aggggcagat     1680

aaaggaagga gatactcatg ttgataaaga gagccctggt cctagacata gttcagccac     1740

aaagtagttg tccctttgtg gacaagtttc ccaaattccc tggacctctg cttccccatc     1800

tgttaaatga gagaatagag tatggttgat tcccagcatt cagtggtcct gtcaagcaac     1860

ctaacaggct agttctaatt ccctattggg tagatgaggg gatgacaaag aacagttttt     1920

aagctatata ggaaacattg ttattggtgt tgccctatcg tgatttcagt tgaattcatg     1980

tgaaaataat agccatcctt ggcctggcgc ggtggctcac acctgtaatc ccagcacttt     2040

tggaggccaa ggtgggtgga tcacctgagg tcaggagttc aagaccagcc tggccaacat     2100

gatgaaaccc cgtctctact aaaaatacaa aaaattagcc gggcatgatg gcaggtgcct     2160

gtaatcccag ctacttggga ggctgaagcg gaagaatcgc ttgaacccag aggtggaggt     2220

tgcagtgagc cgagatcgtg ccattgcact gtaacctggg tgactgagca aaactctgtc     2280

tcaaaataat aataacaata taataataat aatagccatc ctttattgta cccttactgg     2340

gttaatcgta ttataccaca ttacctcatt ttaattttta ctgacctgca ctttatacaa     2400

agcaacaagc ctccaggaca ttaaaattca tgcaaagtta tgctcatgtt atattatttt     2460

cttacttaaa gaaggattta ttagtggctg ggcatggtgg cgtgcacctg taatcccagg     2520

tactcaggag gctgagacgg gagaattgct tgaccccagg cggaggaggt tacagtgagt     2580

cgagatcgta cctgagcgac agagcgagac tccgtctcaa aaaaaaaaaa aaggagggtt     2640

tattaatgag aagtttgtat taatatgtag caaaggcttt tccaatgggt gaataaaaac     2700

acattccatt aagtcaagct gggagcagtg gcatatacct atagtcccag ctgcacagga     2760

ggctgagaca ggaggattgc ttgaagccag gaattggaga tcagcctggg caacacagca     2820

agatcctatc tcttaaaaaa agaaaaaaaa acctattaat aataaaacag tataaacaaa     2880

agctaaatag gtaaaatatt ttttctgaaa taaaattatt ttttgagtct gatggaaatg     2940

tttaagtgca gtaggccagt gccagtgaga aaataaataa catcatacat gtttgtatgt     3000

gtttgcatct tgcttctact gaaagtttca gtgcacccca cttacttaga actcggtgac     3060

atgatgtact cctttatctg ggacacagca caaaagaggt atgcagtggg gctgctctga     3120

catgaaagtg gaagttaagg aatctgggct cttatggggt ccttgtgggc cagcccttca     3180

ggcctatttt actttcattt tacatatagc tctaattggt ttgattatct cgttcccaag     3240

gcagtgggag atccccattt aaggaaagaa aaggggcctg gcacagtggc tcatgcctgt     3300

aatcccagca ctttgggagg ctgaggcaag tgtatcacct gaggtcagga gttcaagacc     3360

agcctggcca acatggcaaa atcccgtctc tactaaaaat attaaaaaat tggctgggcg     3420

tggtggttcg tgcctataat ttcagctact caggaggctg aggcaggaga atcgctgtaa     3480

cctggggggt ggaggttgca gtgagacgag atcatgccac ttcactccag cctggccaac     3540

agagccatac tccgtctcaa ataaataaat aaataaataa agggacttca aacacatgaa     3600

cagcagccag gggaagaatc aaaatcatat tctgtcaagc aaactggaaa agtaccactg     3660

tgtgtaccaa tagcctcccc accacagacc ctgggagcat cgcctcattt atggtgtggt     3720

ccagtcatcc atgtgaagga tgagtttcca ggaaaaggtt attaaatatt cactgtaaca     3780

tactggagga ggtgaggaat tgcataatac aatcttagaa aacttttttt tcccctttct     3840

attttttgag acaggatctc actttggcac tcaggctgga ggacagtggt acaatcaaag     3900

ctcatggcag cctcgacctc cctgggcttg ggcaatcctc ccacaggtgt gcacctccat     3960

agctggctaa tttgtgtatt ttttgtagag atggggtttc accatgttgc ccaggctggt     4020

ctctaacact taggctcaag tgatccacct gcctcgtcct cccaagatgc tgggattaca     4080

ggtgtgtgcc acaggtgttc atcagaaagc tttttctatt atttttacct tcttgagtgg     4140

gtagaacctc agccacatag aaaataaaat gttctggcat gacttattta gctctctgga     4200

attacaaaga aggaatgagg tgtgtaaaag agaacctggg tttttgaatc acaaatttag     4260

aatttaatcg aaactctgcc tcttacttgt ttgtagacac tgacagtggc ctcatgtttt     4320

tttttttttt aatctataaa atggagatat ctaacatgtt gagcctgggc ccacaggcaa     4380

agcacaatcc tgatgtgaga agtactcagt tcatgacaac tgttgttctc acatgcatag     4440

cataatttca tattcacatt ggaggacttc tcccaaaata tggatgacgt tccctactca     4500

accttgaact taatcaaaat actcagttta cttaacttcg tattagattc tgattccctg     4560

gaaccattta tcgtgtgcct taccatgctt atattttact tgatcttttg cataccttct     4620

aaaactattt tagccaattt aaaatttgac agtttgcatt aaattatagg tttacaatat     4680

gctttatcca gctatacctg ccccaaattc tgacagatgc ttttgccacc tctaaaggaa     4740

gacccatgtt catagtgatg gagtttgtgt ggactaacca tgcaaggttg ccaaggaaaa     4800

atcgctttac gcttccaagg tacacactaa gatgaaagta attttagtcc gtgtccagtt     4860

ggattcttgg cacatagtta tcttctgcta gaacaaacta aaacagctac atgccagcaa     4920

gggagaaagg ggaaggaggg gcaaagtttt gaaatttcat gtaaatttat gctgttcaaa     4980

acgacgagtt catgactttg tgtatagagt aagaaatgcc ttttcttttt tgagacagag     5040

tcttgctctg tcacccaggc tggagtgcag tggcacgatc tgggctcact acaacctccg     5100

cctcctgggt tcaagcaatt ctctgcctca gcctcccgag tagctgggat tacaggtgcc     5160

tgccaccaca cccggctaat ttttgtattt ttagtagaga cggggtttca ccatcatggc     5220

caggctggtc ttgaactcct gacctagtaa tccacctgcc tccgcctccc aaagtgctgg     5280

gattacaggc gtgagccact gcacccagcc agaaatgcct tctaatcttt ggtttatctt     5340

aattagccag gacacttgga gtgcatcccg aagtacctga tcagtggccc ctttggaatg     5400

tgtaaaactc agctcactta tatccctgca tccgctacag agacagaatc caagctcata     5460

tgttccatct tctctggctg tatagtttaa ggaatggaag gcaccagaac agatttattg     5520

aaatgtttat tagctgaaga tttatttaga cagttgagga aaacatcagc acccagcagt     5580

aaaattggct ctcaaagatt ttcttctcct gtggaaagtc agacctctga ggccccatcc     5640

aggtagaagt actagtgcaa gaagggcctc tgctgtccac ttgtgtttct gtgatctgtg     5700

ggaacattgt taacgccaca tcttgacctc aaattgttta gctcctggcc agacacggtg     5760

gctcacacct gtaatcccag cactttgaga ggctgaggca ggtggatcac ctgaggttag     5820

gagttcgagg ccagcctggt caacatggta aaaccccgcc tctactaaaa atacaaaaat     5880

tagctggccg tagtggcgca cgcctgttat cccagctact cgggaggctg aggcaggaga     5940

attgcttgaa cctgggtggt ggaggttgca gtgagccgag attacaccac tgcactccag     6000

cctgggtgac aagagggaaa ctccattaaa aaaatgtaat tcccgtgtct gccatcttaa     6060

gtgtaaaggt ggctaaatta tatagaaaaa taagacaata tcatttccca attacattcc     6120

tttcctaccg cactctatga tgctagctga gatttttcca aaagaaaatg gcttaaataa     6180

aaccctaaga gaaagaaaaa ctttaaatcc ctccaaagct caaaagtaat agaaacagat     6240

gagtttggag tcaggatttc tctgtaagat tgcctaggct gtgtactgca catctccagg     6300

tgccactgtt gacagagatt ataactacaa tgtgaagtga atggtgccac tgacagttat     6360

gcaaaccgtc cagagcatag ccacctgatc ctgctgggat tcctcttgcc agtccatcag     6420

cagttcccct tgaaagtttc accaaacatc ccttaaatct gccctctcct gcccgtcccc     6480

agtggaggtc ctcatcattt ttcacctgca tttttgcagg agctttctta tatccacctt     6540

cctccttttc tctcagccca tcatctagct acacagtctc cagggtaagc tttcagaaag     6600

gcaatctctt gtctgtaaaa cctaagcagg accaaggcca agtttcttag cctgaaaaat     6660

gtgcttttct gactgaactg ttcaggcact gactctacat ataattatgc ttttctaccc     6720

cctcacactc aacactttga ctccagcaat cccaaatccc cagatcccta agtgtgctgt     6780

gctattttca cgtggctctc agacttggcc agtgctgttt ccattttggt ctttattccc     6840

cacatctctg cctggggggt agattctacc ctgaaaaatg ttcttggcac agccttgcaa     6900

actcctcctc cactcagcct ctgcctggat gcccttgatt gttccatgtc ctcagcatac     6960

catgtttgtc tttcccagca ctgacctacc atgtgtcacc cctgcttggc tgtaccttcc     7020

atgaggctag gactatgtgt ctcctttgtt gactgctgtt gccctagcat cttgcacagt     7080

tccttgcaca caattagagc tctataaatg tcaaataaat gtgttataat tatatgttta     7140

agatagttgt tcaaataaac tctaaataac cccaac                               7176


<210>  9
<211>  980
<212>  DNA
<213>  Homo sapiens

<400>  9
agtctccctt gggtcagggg tcctggttgc actccgtgct ttgcacaaag caggctctcc       60

atttttgtta aatgcacgaa tagtgctaag ctgggaagtt cttcctgagg tctaacctct      120

agctgctccc ccacagaaga gtgcctgcgg ccagtggcca ccaggggtcg ccgcagcacc      180

cagcgctgga gggcggagcg ggcggcagac ccggagcagc atgtggactc tcgggcgccg      240

cgcagtagcc ggcctcctgg cgtcacccag cccagcccag gcccagaccc tcacccgggt      300

cccgcggccg gcagagttgg ccccactctg cggccgccgt ggcctgcgca ccgacatcga      360

tgcgacctgc acgccccgcc gcgcaagttc gaaccaacgt ggcctcaacc agatttggaa      420

tgtcaaaaag cagagtgtct atttgatgaa tttgaggaaa tctggaactt tgggccaccc      480

aggctctcta gatgagacca cctatgaaag actagcagag gaaacgctgg actctttagc      540

agagtttttt gaagaccttg cagacaagcc atacacgttt gaggactatg atgtctcctt      600

tgggagtggt gtcttaactg tcaaactggg tggagatcta ggaacctatg tgatcaacaa      660

gcagacgcca aacaagcaaa tctggctatc ttctccatcc aggttaacgt ggctcctgtg      720

gctgttccat ccctgaggaa aagtgaggac catgctctcc aaacaggcca tgtgctggac      780

tacctctgtt tctgtctcct gggattccaa tcagcaagtg agcaacgaag caacccagac      840

agtgtggttc ataggatggc tgggtaagtg gctgtttgtt ttttccttac tgtggatatg      900

tatcagtgaa ggaatctgta gaacattctt gatgggaaca tttagtcata tcaagtcaat      960

aaattaatgt ttaggctggg                                                  980


<210>  10
<211>  210
<212>  PRT
<213>  Macaca fascicularis

<400>  10

Met Trp Thr Phe Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Ala Pro Arg Leu Ala Glu 
            20                  25                  30          


Leu Ala Gln Leu Cys Ser Arg Arg Gly Leu Arg Thr Gly Ile Asn Ala 
        35                  40                  45              


Thr Cys Thr Thr His His Thr Ser Ser Asn Leu Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Arg Asn Val Lys Arg Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Asp Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Gly Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  11
<211>  210
<212>  PRT
<213>  Macaca fascicularis

<400>  11

Met Trp Thr Phe Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Ala Pro Arg Leu Ala Glu 
            20                  25                  30          


Leu Ala Gln Leu Cys Ser Arg Arg Gly Leu Arg Thr Gly Ile Asn Ala 
        35                  40                  45              


Thr Arg Thr Thr His His Thr Ser Ser Asn Leu Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Arg Asn Val Lys Arg Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Asp Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Arg Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Gly Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210>  12
<211>  210
<212>  PRT
<213>  Macaca mulatta

<400>  12

Met Trp Thr Phe Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Ala Pro Arg Leu Ala Glu 
            20                  25                  30          


Leu Ala Gln Leu Cys Ser Arg Arg Gly Leu Arg Thr Gly Ile Asn Ala 
        35                  40                  45              


Thr Cys Thr Thr His His Thr Ser Ser Asn Leu Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Arg Asn Val Lys Arg Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Asp Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Gly Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


