                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Non-Human Animals Expressing Humanized C1Q Complex

<130>  35342 (10353WO01)

<150>  62/565,438
<151>  2017-09-29

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  245
<212>  PRT
<213>  Mus musculus

<400>  1

Met Glu Thr Ser Gln Gly Trp Leu Val Ala Cys Val Leu Thr Met Thr 
1               5                   10                  15      


Leu Val Trp Thr Val Ala Glu Asp Val Cys Arg Ala Pro Asn Gly Lys 
            20                  25                  30          


Asp Gly Ala Pro Gly Asn Pro Gly Arg Pro Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Arg Gly Glu Pro Gly Ala Ala Gly Ile Arg Thr Gly Ile Arg 
    50                  55                  60                  


Gly Phe Lys Gly Asp Pro Gly Glu Ser Gly Pro Pro Gly Lys Pro Gly 
65                  70                  75                  80  


Asn Val Gly Leu Pro Gly Pro Ser Gly Pro Leu Gly Asp Ser Gly Pro 
                85                  90                  95      


Gln Gly Leu Lys Gly Val Lys Gly Asn Pro Gly Asn Ile Arg Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Gln Asn Pro Met Thr Leu Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Lys Val Leu Thr Asn Gln Glu Ser Pro Tyr 
    130                 135                 140                 


Gln Asn His Thr Gly Arg Phe Ile Cys Ala Val Pro Gly Phe Tyr Tyr 
145                 150                 155                 160 


Phe Asn Phe Gln Val Ile Ser Lys Trp Asp Leu Cys Leu Phe Ile Lys 
                165                 170                 175     


Ser Ser Ser Gly Gly Gln Pro Arg Asp Ser Leu Ser Phe Ser Asn Thr 
            180                 185                 190         


Asn Asn Lys Gly Leu Phe Gln Val Leu Ala Gly Gly Thr Val Leu Gln 
        195                 200                 205             


Leu Arg Arg Gly Asp Glu Val Trp Ile Glu Lys Asp Pro Ala Lys Gly 
    210                 215                 220                 


Arg Ile Tyr Gln Gly Thr Glu Ala Asp Ser Ile Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  2
<211>  253
<212>  PRT
<213>  Mus musculus

<400>  2

Met Lys Thr Gln Trp Gly Glu Val Trp Thr His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Phe Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Gly Ile Pro Gly Ile Pro Gly Val Pro Gly Val Pro Gly Ser Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp Leu Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Thr Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                85                  90                  95      


Gly Thr Pro Gly Pro Ser Gly Pro Arg Gly Pro Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Tyr Gly Ala Thr Gln Lys Val Ala Phe Ser Ala Leu Arg Thr Ile 
        115                 120                 125             


Asn Ser Pro Leu Arg Pro Asn Gln Val Ile Arg Phe Glu Lys Val Ile 
    130                 135                 140                 


Thr Asn Ala Asn Glu Asn Tyr Glu Pro Arg Asn Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Val Arg Gly Arg Asp Arg Asp Ser Met Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Gln Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Val Val Leu Lys Leu Glu Gln Glu Glu Val Val His Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Ile Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Thr Gly Phe Leu Leu Phe Pro Asp Met Asp Ala 
                245                 250             


<210>  3
<211>  246
<212>  PRT
<213>  Mus musculus

<400>  3

Met Val Val Gly Pro Ser Cys Gln Pro Pro Cys Gly Leu Cys Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ala Leu Pro Leu Arg Ser Gln Ala Ser Ala Gly 
            20                  25                  30          


Cys Tyr Gly Ile Pro Gly Met Pro Gly Met Pro Gly Ala Pro Gly Lys 
        35                  40                  45              


Asp Gly His Asp Gly Leu Gln Gly Pro Lys Gly Glu Pro Gly Ile Pro 
    50                  55                  60                  


Ala Val Pro Gly Thr Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Met Pro Gly His Arg Gly Lys Asn Gly Pro Arg Gly Thr Ser Gly Leu 
                85                  90                  95      


Pro Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Val Glu 
            100                 105                 110         


Gly Arg Tyr Lys Gln Lys His Gln Ser Val Phe Thr Val Thr Arg Gln 
        115                 120                 125             


Thr Thr Gln Tyr Pro Glu Ala Asn Ala Leu Val Arg Phe Asn Ser Val 
    130                 135                 140                 


Val Thr Asn Pro Gln Gly His Tyr Asn Pro Ser Thr Gly Lys Phe Thr 
145                 150                 155                 160 


Cys Glu Val Pro Gly Leu Tyr Tyr Phe Val Tyr Tyr Thr Ser His Thr 
                165                 170                 175     


Ala Asn Leu Cys Val His Leu Asn Leu Asn Leu Ala Arg Val Ala Ser 
            180                 185                 190         


Phe Cys Asp His Met Phe Asn Ser Lys Gln Val Ser Ser Gly Gly Val 
        195                 200                 205             


Leu Leu Arg Leu Gln Arg Gly Asp Glu Val Trp Leu Ser Val Asn Asp 
    210                 215                 220                 


Tyr Asn Gly Met Val Gly Ile Glu Gly Ser Asn Ser Val Phe Ser Gly 
225                 230                 235                 240 


Phe Leu Leu Phe Pro Asp 
                245     


<210>  4
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  5
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly Pro Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly Pro Lys 
                85                  90                  95      


Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu Ser Gly 
            100                 105                 110         


Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
        115                 120                 125             


Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
    130                 135                 140                 


Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
            180                 185                 190         


Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
        195                 200                 205             


Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
    210                 215                 220                 


Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser Ile Phe 
225                 230                 235                 240 


Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250     


<210>  6
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  7
<211>  245
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Glu Thr Ser Gln Gly Trp Leu Val Ala Cys Val Leu Ala Val Thr 
1               5                   10                  15      


Leu Val Trp Thr Val Ala Glu Asp Val Cys Arg Ala Pro Asn Gly Lys 
            20                  25                  30          


Asp Gly Val Ala Gly Ile Pro Gly Arg Pro Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Arg Gly Glu Pro Gly Ala Ala Gly Ile Arg Thr Gly Ile Arg 
    50                  55                  60                  


Gly Leu Lys Gly Asp Met Gly Glu Ser Gly Pro Pro Gly Lys Pro Gly 
65                  70                  75                  80  


Asn Val Gly Phe Pro Gly Pro Thr Gly Pro Leu Gly Asn Ser Gly Pro 
                85                  90                  95      


Gln Gly Leu Lys Gly Val Lys Gly Asn Pro Gly Asn Ile Arg Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Gln Asn Pro Pro Thr Tyr Gly 
        115                 120                 125             


Asn Val Val Val Phe Asp Lys Val Leu Thr Asn Gln Glu Asn Pro Tyr 
    130                 135                 140                 


Gln Asn Arg Thr Gly His Phe Ile Cys Ala Val Pro Gly Phe Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Ile Ser Lys Trp Asp Leu Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Pro Arg Asn Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Asn Ser Lys Gly Leu Phe Gln Val Leu Ala Gly Gly Thr Val Leu Gln 
        195                 200                 205             


Leu Gln Arg Gly Asp Glu Val Trp Ile Glu Lys Asp Pro Ala Lys Gly 
    210                 215                 220                 


Arg Ile Tyr Gln Gly Thr Glu Ala Asp Ser Ile Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  8
<211>  253
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Lys Thr Gln Trp Ser Glu Ile Leu Thr Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Ser 
            20                  25                  30          


Pro Gly Ile Pro Gly Val Pro Gly Ile Pro Gly Val Pro Gly Ser Asp 
        35                  40                  45              


Gly Lys Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp His Gly Glu Leu Gly Glu Lys Gly Asp Ala Gly Ile 
65                  70                  75                  80  


Pro Gly Ile Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                85                  90                  95      


Gly Ala Pro Gly Pro Pro Gly Pro Arg Gly Pro Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Tyr Lys Ala Thr Gln Lys Val Ala Phe Ser Ala Leu Arg Thr Val 
        115                 120                 125             


Asn Ser Ala Leu Arg Pro Asn Gln Ala Ile Arg Phe Glu Lys Val Ile 
    130                 135                 140                 


Thr Asn Val Asn Asp Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Ile Val Arg Gly Arg Asp Arg Asp Arg Met Gln 
            180                 185                 190         


Lys Val Leu Thr Phe Cys Asp Tyr Ala Gln Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Val Val Leu Lys Leu Glu Gln Glu Glu Val Val His Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Val Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Thr Gly Phe Leu Leu Phe Pro Asp Met Asp Val 
                245                 250             


<210>  9
<211>  248
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Leu Arg Met Val Val Gly Thr Ser Cys Gln Pro Gln His Gly Leu 
1               5                   10                  15      


Tyr Leu Leu Leu Leu Leu Leu Ala Leu Pro Leu Arg Ser Gln Ala Asn 
            20                  25                  30          


Ala Gly Cys Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Thr Pro 
        35                  40                  45              


Gly Lys Asp Gly His Asp Gly Leu Gln Gly Pro Lys Gly Glu Pro Gly 
    50                  55                  60                  


Ile Pro Ala Ile Pro Gly Thr Gln Gly Pro Lys Gly Gln Lys Gly Glu 
65                  70                  75                  80  


Pro Gly Met Pro Gly His Arg Gly Lys Asn Gly Pro Met Gly Thr Ser 
                85                  90                  95      


Gly Ser Pro Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
            100                 105                 110         


Glu Glu Gly Arg Tyr Lys Gln Lys His Gln Ser Val Phe Thr Val Thr 
        115                 120                 125             


Arg Gln Thr Ala Gln Tyr Pro Ala Ala Asn Gly Leu Val Lys Phe Asn 
    130                 135                 140                 


Ser Ala Ile Thr Asn Pro Gln Gly Asp Tyr Asn Thr Asn Thr Gly Lys 
145                 150                 155                 160 


Phe Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Val His His Thr Ser 
                165                 170                 175     


Gln Thr Ala Asn Leu Cys Val Gln Leu Leu Leu Asn Asn Ala Lys Val 
            180                 185                 190         


Thr Ser Phe Cys Asp His Met Ser Asn Ser Lys Gln Val Ser Ser Gly 
        195                 200                 205             


Gly Val Leu Leu Arg Leu Gln Arg Gly Asp Glu Val Trp Leu Ala Val 
    210                 215                 220                 


Asn Asp Tyr Asn Gly Met Val Gly Thr Glu Gly Ser Asp Ser Val Phe 
225                 230                 235                 240 


Ser Gly Phe Leu Leu Phe Pro Asp 
                245             


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence of a chimeric mouse/human C1qa

<400>  10

Met Glu Thr Ser Gln Gly Trp Leu Val Ala Cys Val Leu Thr Met Thr 
1               5                   10                  15      


Leu Val Trp Thr Val Ala Glu Asp Val Cys Arg Ala Pro Asn Gly Lys 
            20                  25                  30          


Asp Gly Ala Pro Gly Asn Pro Gly Arg Pro Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Arg Gly Glu Pro Gly Ala Ala Gly Ile Arg Thr Gly Ile Arg 
    50                  55                  60                  


Gly Phe Lys Gly Asp Pro Gly Glu Ser Gly Pro Pro Gly Lys Pro Gly 
65                  70                  75                  80  


Asn Val Gly Leu Pro Gly Pro Thr Gly Pro Leu Gly Asp Ser Gly Pro 
                85                  90                  95      


Gln Gly Leu Lys Gly Val Lys Gly Asn Pro Gly Asn Ile Arg Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  11
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence of a chimeric mouse/human C1qb

<400>  11

Met Lys Thr Gln Trp Gly Glu Val Trp Thr His Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Phe Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Pro 
            20                  25                  30          


Pro Gly Ile Pro Gly Ile Pro Gly Val Pro Gly Val Pro Gly Ser Asp 
        35                  40                  45              


Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp Leu Gly Glu Phe Gly Glu Lys Gly Asp Pro Gly Ile 
65                  70                  75                  80  


Pro Gly Thr Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                85                  90                  95      


Gly Thr Pro Gly Pro Ser Gly Pro Arg Gly Pro Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Tyr Gly Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
        115                 120                 125             


Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
    130                 135                 140                 


Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
            180                 185                 190         


Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
        195                 200                 205             


Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
    210                 215                 220                 


Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser Ile Phe 
225                 230                 235                 240 


Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250     


<210>  12
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence of a chimeric mouse/human C1qc

<400>  12

Met Val Val Gly Pro Ser Cys Gln Pro Pro Cys Gly Leu Cys Leu Leu 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ala Leu Pro Leu Arg Ser Gln Ala Ser Ala Gly 
            20                  25                  30          


Cys Tyr Gly Ile Pro Gly Met Pro Gly Met Pro Gly Ala Pro Gly Lys 
        35                  40                  45              


Asp Gly His Asp Gly Leu Gln Gly Pro Lys Gly Glu Pro Gly Ile Pro 
    50                  55                  60                  


Ala Val Pro Gly Thr Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly 
65                  70                  75                  80  


Met Pro Gly His Arg Gly Lys Asn Gly Pro Arg Gly Thr Ser Gly Leu 
                85                  90                  95      


Pro Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Val Glu 
            100                 105                 110         


Gly Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln 
        115                 120                 125             


Thr His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val 
    130                 135                 140                 


Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr 
145                 150                 155                 160 


Cys Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr 
                165                 170                 175     


Ala Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr 
            180                 185                 190         


Phe Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val 
        195                 200                 205             


Leu Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp 
    210                 215                 220                 


Tyr Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly 
225                 230                 235                 240 


Phe Leu Leu Phe Pro Asp 
                245     


<210>  13
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  13
catacccagt gtccctgtgt gtctctgtag ggacaccatg ggtaccgatt taaatgatcc       60

agtggtc                                                                 67


<210>  14
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  14
gcagccccta gataacttcg tataatgtat gctatacgaa gttatcctag gctatccaac       60

accatcttcc tgc                                                          73


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  15
tcccgcacca tcctggaggc aat                                               23


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
taagcgttct ctccggctgg                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  17
cgcttctcag gacccctaaa c                                                 21


<210>  18
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
cgatactgtc gtcgtcccct caaactg                                           27


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
ggagtgcgat cttcctgagg                                                   20


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
cgcatcgtaa ccgtgcatc                                                    19


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
tgggcacaac agacaatcgg ctg                                               23


<210>  22
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  22
ggtggagagg ctattcggc                                                    19


<210>  23
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
gaacacggcg gcatcag                                                      17


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
aggaccatca acagcccctt gcgac                                             25


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
gaaagtcgcc ttctctgccc                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
cgaagcgaat gacctggttc                                                   20


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  27
tgacaaggtc ctcaccaacc aggagag                                           27


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  28
cgcttggcaa cgtggttat                                                    19


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  29
cccgtgtggt tctggtatgg                                                   20


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  30
tatgagccac gcaacggcaa gttca                                             25


<210>  31
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  31
tcaccaacgc gaacgagaa                                                    19


<210>  32
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  32
ggccaggcac cttgca                                                       16


<210>  33
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  33
cccatcctca ctcagacctc ttcctcca                                          28


<210>  34
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  34
cacctcgctc cctctgctt                                                    19


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  35
caggaaccag ggtggacttc                                                   20


<210>  36
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  36
caacgtggtc atcttcgaca cggtca                                            26


<210>  37
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  37
cggaaccccc caatgg                                                       16


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  38
tggttctggt acggttcttc ct                                                22


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  39
accatcaacg tccccctgcg c                                                 21


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  40
aatcgccttc tctgccacaa                                                   20


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  41
gtggtcgaag cggatggt                                                     18


<210>  42
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  42
cacctgcaaa gtccccggcc tc                                                22


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  43
tgacacgagc actggcaagt                                                   20


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  44
cgacgcgtgg tagacaaagt ag                                                22


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  45
acgagcgggt tcggcccatt c                                                 21


<210>  46
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  46
tgcggccgat cttagcc                                                      17


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  47
ttgaccgatt ccttgcgg                                                     18


<210>  48
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  48
cggcccccaa ggactgaagg gcgtgaaagg caatccaggc aatatcaggg accagccgag       60

gccagccttc tccgccattc ggcggaaccc cccaatgggg ggc                        103


<210>  49
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  49
ttgagaggga ggcctaagaa taataacaat ccagtgctta agagtcaggc gcgatcgctg       60

atgcacgcct ttaatcccag cacttgggag gcagagacag gtga                       104


<210>  50
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  50
gccaggggac ccaggcccca gggggcctcc gggggagcca ggtgtggagg gccgatacaa       60

gcagaaattc cagtcagtgt tcacggtcac tcggcagacc cacca                      105


<210>  51
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  51
tgaatttcgg atcttcaact ttgcatcagc catagctggg ctctggactc tacctaacta       60

taacggtcct aaggtagcga aagggggatg atttggagt                              99


<210>  52
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  52
tccaggcccc tctggacccc gcggtcccaa aggcgattct ggggactacg gggctacaca       60

gaaaatcgcc ttctctgcca caagaaccat caacgtcccc ctgcgccggg                 110


<210>  53
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  53
gcacctggca caccagaagt gccatgctca gaaatgttgg ttacatgaat gaatgcggcc       60

gcaccggtat aacttcgtat aatgtatgct atacgaagtt a                          101


<210>  54
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  54
ccggcgcgcc ataacttcgt ataatgtatg ctatacgaag ttatgtcgac gaatgttcat       60

aggctgggga gatggctcag tcagtaaagt acttagcttg c                          101


<210>  55
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence of a chimeric rat/human C1qa

<400>  55

Met Glu Thr Ser Gln Gly Trp Leu Val Ala Cys Val Leu Ala Val Thr 
1               5                   10                  15      


Leu Val Trp Thr Val Ala Glu Asp Val Cys Arg Ala Pro Asn Gly Lys 
            20                  25                  30          


Asp Gly Val Ala Gly Ile Pro Gly Arg Pro Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Arg Gly Glu Pro Gly Ala Ala Gly Ile Arg Thr Gly Ile Arg 
    50                  55                  60                  


Gly Leu Lys Gly Asp Met Gly Glu Ser Gly Pro Pro Gly Lys Pro Gly 
65                  70                  75                  80  


Asn Val Gly Phe Pro Gly Pro Thr Gly Pro Leu Gly Asn Ser Gly Pro 
                85                  90                  95      


Gln Gly Leu Lys Gly Val Lys Gly Asn Pro Gly Asn Ile Arg Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  56
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence of a chimeric rat/human C1qb

<400>  56

Met Lys Thr Gln Trp Ser Glu Ile Leu Thr Pro Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gly Leu Leu His Val Ser Trp Ala Gln Ser Ser Cys Thr Gly Ser 
            20                  25                  30          


Pro Gly Ile Pro Gly Val Pro Gly Ile Pro Gly Val Pro Gly Ser Asp 
        35                  40                  45              


Gly Lys Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu Pro Gly 
    50                  55                  60                  


Leu Ala Gly Asp His Gly Glu Leu Gly Glu Lys Gly Asp Ala Gly Ile 
65                  70                  75                  80  


Pro Gly Ile Pro Gly Lys Val Gly Pro Lys Gly Pro Val Gly Pro Lys 
                85                  90                  95      


Gly Ala Pro Gly Pro Pro Gly Pro Arg Gly Pro Lys Gly Asp Ser Gly 
            100                 105                 110         


Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg Thr Ile 
        115                 120                 125             


Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His Val Ile 
    130                 135                 140                 


Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg Gly 
                165                 170                 175     


Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln Lys Val 
            180                 185                 190         


Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr Thr Gly 
        195                 200                 205             


Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala 
    210                 215                 220                 


Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser Ile Phe 
225                 230                 235                 240 


Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250     


<210>  57
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide sequence of a chimeric rat/human C1qc

<400>  57

Met Leu Arg Met Val Val Gly Thr Ser Cys Gln Pro Gln His Gly Leu 
1               5                   10                  15      


Tyr Leu Leu Leu Leu Leu Leu Ala Leu Pro Leu Arg Ser Gln Ala Asn 
            20                  25                  30          


Ala Gly Cys Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Thr Pro 
        35                  40                  45              


Gly Lys Asp Gly His Asp Gly Leu Gln Gly Pro Lys Gly Glu Pro Gly 
    50                  55                  60                  


Ile Pro Ala Ile Pro Gly Thr Gln Gly Pro Lys Gly Gln Lys Gly Glu 
65                  70                  75                  80  


Pro Gly Met Pro Gly His Arg Gly Lys Asn Gly Pro Met Gly Thr Ser 
                85                  90                  95      


Gly Ser Pro Gly Asp Pro Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly 
            100                 105                 110         


Glu Glu Gly Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr 
        115                 120                 125             


Arg Gln Thr His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn 
    130                 135                 140                 


Ala Val Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys 
145                 150                 155                 160 


Phe Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser 
                165                 170                 175     


His Thr Ala Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val 
            180                 185                 190         


Val Thr Phe Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly 
        195                 200                 205             


Gly Val Leu Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val 
    210                 215                 220                 


Asn Asp Tyr Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe 
225                 230                 235                 240 


Ser Gly Phe Leu Leu Phe Pro Asp 
                245             


<210>  58
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  58
gattctccca atctctcctc tgcaggacca ctggatcatt taaatcggta cccatgatgt       60

tcctgcagag acacacaggg accccgggca tgctggacag tca                        103


<210>  59
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  59
tagttatcga gcccggggat ccactagttc tagtgtttaa actctagccg ggggatccag       60

acatgataag atacattgat gagtttggac aaaccacaac t                          101


<210>  60
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  60
aggattactg gcagggagga ggttttggat aggagtgatt tgaccccgtg agctagcata       60

acttcgtata gcatacatta tacgaagtta tctaggggct g                          101


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  61
aacccaccga cgtatggcaa cgt                                               23


<210>  62
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  62
gccagctttc tcagctattc g                                                 21


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  63
gcggttctgg tatggattct c                                                 21


<210>  64
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  64
aaacaccttc caggtcacca cggg                                              24


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  65
tctcaccttc tgcgactatg c                                                 21


<210>  66
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  66
cctgctccag cttcaagact ac                                                22


<210>  67
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  67
acgagcgggt tcggcccatt c                                                 21


<210>  68
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  68
tgcggccgat cttagcc                                                      17


<210>  69
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  69
ttgaccgatt ccttgcgg                                                     18


<210>  70
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  70
cgatactgtc gtcgtcccct caaactg                                           27


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  71
ggagtgcgat cttcctgagg                                                   20


<210>  72
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  72
cgcatcgtaa ccgtgcatc                                                    19


<210>  73
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  73
aacccaccga cgtatggcaa cgt                                               23


<210>  74
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  74
gccagctttc tcagctattc g                                                 21


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  75
gcggttctgg tatggattct c                                                 21


<210>  76
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  76
aaacaccttc caggtcacca cggg                                              24


<210>  77
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  77
tctcaccttc tgcgactatg c                                                 21


<210>  78
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  78
cctgctccag cttcaagact ac                                                22


<210>  79
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  79
ccttccaggt gctgtcccag tg                                                22


<210>  80
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  80
gtacccggct actactactt ca                                                22


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  81
gagacgatgg acaggcagat ttc                                               23


<210>  82
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  82
accatcaacg tccccctgcg c                                                 21


<210>  83
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  83
aatcgccttc tctgccacaa                                                   20


<210>  84
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  84
gtggtcgaag cggatggt                                                     18


<210>  85
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  85
cacctgcaaa gtccccggcc tc                                                22


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  86
tgacacgagc actggcaagt                                                   20


<210>  87
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  87
cgacgcgtgg tagacaaagt ag                                                22


<210>  88
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  88
gcccccaagg gttgaaaggt gtgaaaggca atccgggcaa tatcagggac cagccgaggc       60

cagccttctc cgccattcgg cggaaccccc caatgggggg ca                         102


<210>  89
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  89
gcattgagag ggaggcctaa gaataataac aatccagtgc ttaagagtca ggcgctgggt       60

agctgcccca cgttctgcca tctcctgcac tccctgttgc ggggcc                     106


<210>  90
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  90
gggatccagg ccccaggggt cctcccgggg agccgggtga ggagggtcga tacaagcaga       60

aattccagtc agtgttcacg gtcactcggc agacccacca gcccc                      105


<210>  91
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  91
tgaatttcgg atcttcaact ttgcatcagc catagctggg ctctggactc gaatggcagg       60

ctgggtccag cacccggacg cccgcctcgc tccctctgct                            100


<210>  92
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  92
gcccccctgg accccgcggt cccaaaggtg actctggaga ctacaaggct acccagaaaa       60

tcgccttctc tgccacaaga accatcaacg tccccctgcg ccgg                       104


<210>  93
<211>  101
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  93
ctggcacacc agaagtgcca tgctcagaaa tgttggttac atgaatgaat gtcgagataa       60

cttcgtataa tgtatgctat acgaagttat atgcatgcca g                          101


<210>  94
<211>  132
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic oligonucleotide

<400>  94
ggcggcctag ataacttcgt ataatgtatg ctatacgaag ttatgctagg taactataac       60

ggtcctaagg tagcgagcta gctcacgggg tcaaatcact cctatccaaa acctcctccc      120

tgccagtaat cc                                                          132


