                         SEQUENCE LISTING

<110>  ELI LILLY AND COMPANY
 
<120>  ANTI-PACAP ANTIBODY

<130>  X21602

<150>  62/565,278
<151>  2017-09-29

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HC


<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa at residue 62 is one of Asp, Ala, Glu, and Gln

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa at residue 104 is one of Asn and Thr

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa at residue 231 is one of Pro and Ser

<220>
<221>  MISC_FEATURE
<222>  (237)..(237)
<223>  Xaa at residue 237 is one of Ala and Phe

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa at residue 238 is one of Ala and Leu

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Leu Ser Gly Gly Ser Thr Tyr Tyr Ala Xaa Ser His 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Val Gly Ala Ser Xaa His Asn Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Xaa Cys Pro Ala Pro Glu Xaa Xaa Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LC


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at residue 30 is one of Ser and Trp

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa at residue 55 is one of Leu and Phe

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Xaa Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Asp Ala Ser Gln Leu Xaa Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Asp Leu Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR1

<400>  3

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Tyr Met Ser 
1               5                   10              


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR2


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa at residue 13 is one of Asp, Ala, Glu and Gln

<400>  4

Ala Ile Ser Leu Ser Gly Gly Ser Thr Tyr Tyr Ala Xaa Ser His Lys 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCDR3


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at residue 8 is one of Asn and Thr

<400>  5

Val Arg Glu Val Gly Ala Ser Xaa His Asn Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR1


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at residue 7 is one Ser and Trp

<400>  6

Arg Ala Ser Gln Ser Ile Xaa Arg Trp Leu Ala 
1               5                   10      


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR2


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at residue 7 is one of Leu and Phe

<400>  7

His Asp Ala Ser Gln Leu Xaa Glu 
1               5               


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCDR3

<400>  8

Gln Gln Phe Asp Leu Leu Pro Leu Thr 
1               5                   


<210>  9
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified HCVR


<220>
<221>  MISC_FEATURE
<222>  (62)..(62)
<223>  Xaa at residue 62 is one of Asp, Ala, Glu and Gln

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa at residue 104 is one of Asn and Thr

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Leu Ser Gly Gly Ser Thr Tyr Tyr Ala Xaa Ser His 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Val Gly Ala Ser Xaa His Asn Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplified LCVR


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa at residue 30 is one of Ser and Trp

<220>
<221>  MISC_FEATURE
<222>  (55)..(55)
<223>  Xaa at residue 55 is one of Leu and Phe

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Xaa Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Asp Ala Ser Gln Leu Xaa Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Asp Leu Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  11
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence Encoding HC of Exemplified Ab B

<400>  11
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctattaca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtctga gtggtggtag cacatactac      180

gcagcgtccc acaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgt ccgggaggtg      300

ggagctagca ctcacaacta ctacggtatg gacgtctggg gccaagggac catggtcacc      360

gtctcttcag cttctaccaa gggcccatcg gtcttcccgc tagcgccctg ctccaggagc      420

acctccgaga gcacagccgc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acgaagacct acacctgcaa cgtagatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagtcca aatatggtcc cccatgccca ccctgcccag cacctgaggc cgccggggga      720

ccatcagtct tcctgttccc cccaaaaccc aaggacactc tcatgatctc ccggacccct      780

gaggtcacgt gcgtggtggt ggacgtgagc caggaagacc ccgaggtcca gttcaactgg      840

tacgtggatg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagttcaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaacggcaag      960

gagtacaagt gcaaggtctc caacaaaggc ctcccgtcct ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agagccacag gtgtacaccc tgcccccatc ccaggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc     1140

gccgtggagt gggaaagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctctac agcaggctaa ccgtggacaa gagcaggtgg     1260

caggagggga atgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacaca     1320

cagaagagcc tctccctgtc tctgggt                                         1347


<210>  12
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide Sequence Encoding LC of Exemplified Ab B

<400>  12
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca gagtatttgg aggtggttgg cctggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatccacgat gcatcccaat tgttcgaagg ggtcccatca      180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct      240

gaagatattg caacatatta ctgtcaacag tttgatttgc tccctctcac tttcggcgga      300

gggaccaagg tggagatcaa acggaccgtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gc                         642


<210>  13
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant Human PACAP 38


<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  Lys at residue 38 is post-translationally modified by C-terminal 
       amidation

<400>  13

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu Gly Lys Arg Tyr Lys 
            20                  25                  30          


Gln Arg Val Lys Asn Lys 
        35              


<210>  14
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant Human PACAP27


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Leu at residue 27 is post-translationally modified by C-terminal 
       amidation

<400>  14

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


