                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  METHODS OF ISOLATING T CELLS HAVING ANTIGENIC SPECIFICITY FOR A 
       P53 CANCER-SPECIFIC MUTATION

<130>  740175

<150>  US 62/565,464
<151>  2017-09-29

<160>  602   

<170>  PatentIn version 3.5

<210>  1
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  2
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  2

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His 
1               5                   10                  15      


His Glu Arg Cys Ser Asp Ser Asp Gly 
            20                  25  


<210>  3
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val His Val Cys Ala 
1               5                   10                  15      


Cys Pro Gly Arg Asp Arg Arg Thr Glu 
            20                  25  


<210>  4
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  4

Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Leu Arg Pro Ile 
1               5                   10                  15      


Leu Thr Ile Ile Thr Leu Glu Asp Ser 
            20                  25  


<210>  5
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg Asp Trp Arg Thr Glu 
1               5                   10                  15      


Glu Glu Asn Leu Arg Lys Lys Gly Glu 
            20                  25  


<210>  6
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Cys Val Cys Ala 
1               5                   10                  15      


Cys Pro Gly Arg Asp Arg Arg Thr Glu 
            20                  25  


<210>  7
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  7

His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg 
1               5                   10                  15      


Arg Pro Ile Leu Thr Ile Ile Thr Leu 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  8

Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Gln Arg Pro Ile 
1               5                   10                  15      


Leu Thr Ile Ile Thr Leu Glu Asp Ser 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  9

His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Asp Met Asn Arg 
1               5                   10                  15      


Arg Pro Ile Leu Thr Ile Ile Thr Leu 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Leu Val Cys Ala 
1               5                   10                  15      


Cys Pro Gly Arg Asp Arg Arg Thr Glu 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  11

Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro Ile 
1               5                   10                  15      


Leu Thr Ile Ile Thr Leu Glu Asp Ser 
            20                  25  


<210>  12
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Cys Glu Pro Pro 
1               5                   10                  15      


Glu Val Gly Ser Asp Cys Thr Thr Ile 
            20                  25  


<210>  13
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Ser Pro Ile Leu 
1               5                   10                  15      


Thr Ile Ile Thr Leu Glu Asp Ser Ser 
            20                  25  


<210>  14
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His 
1               5                   10                  15      


His Glu Arg Cys Ser Asp Ser Asp Gly Ser Gly Asn Leu Leu Gly Arg 
            20                  25                  30          


Asn Ser Phe Glu Val His Val Cys Ala Cys Pro Gly Arg Asp Arg Arg 
        35                  40                  45              


Thr Glu Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Leu Arg 
    50                  55                  60                  


Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Phe Glu Val Arg Val 
65                  70                  75                  80  


Cys Ala Cys Pro Gly Arg Asp Trp Arg Thr Glu Glu Glu Asn Leu Arg 
                85                  90                  95      


Lys Lys Gly Glu Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            100                 105                 110         


Cys Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu His Tyr Asn 
        115                 120                 125             


Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg Arg Pro Ile 
    130                 135                 140                 


Leu Thr Ile Ile Thr Leu Tyr Met Cys Asn Ser Ser Cys Met Gly Gly 
145                 150                 155                 160 


Met Asn Gln Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser His 
                165                 170                 175     


Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Asp Met Asn Arg Arg 
            180                 185                 190         


Pro Ile Leu Thr Ile Ile Thr Leu Ser Gly Asn Leu Leu Gly Arg Asn 
        195                 200                 205             


Ser Phe Glu Val Leu Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr 
    210                 215                 220                 


Glu Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro 
225                 230                 235                 240 


Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Asp Arg Asn Thr Phe Arg 
                245                 250                 255     


His Ser Val Val Val Pro Cys Glu Pro Pro Glu Val Gly Ser Asp Cys 
            260                 265                 270         


Thr Thr Ile Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Ser 
        275                 280                 285             


Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser 
    290                 295                 300 


<210>  15
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  15

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His 
1               5                   10                  15      


His Glu Arg Cys Ser Asp Ser Asp Gly 
            20                  25  


<210>  16
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  16

Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
1               5                   10                  15      


Cys Pro Gly Arg Asp Arg Arg Thr Glu 
            20                  25  


<210>  17
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  17

Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile 
1               5                   10                  15      


Leu Thr Ile Ile Thr Leu Glu Asp Ser 
            20                  25  


<210>  18
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu 
1               5                   10                  15      


Glu Glu Asn Leu Arg Lys Lys Gly Glu 
            20                  25  


<210>  19
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  19

His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg 
1               5                   10                  15      


Arg Pro Ile Leu Thr Ile Ile Thr Leu 
            20                  25  


<210>  20
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro 
1               5                   10                  15      


Glu Val Gly Ser Asp Cys Thr Thr Ile 
            20                  25  


<210>  21
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu 
1               5                   10                  15      


Thr Ile Ile Thr Leu Glu Asp Ser Ser 
            20                  25  


<210>  22
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His 
1               5                   10                  15      


His Glu Arg Cys Ser Asp Ser Asp Gly Ser Gly Asn Leu Leu Gly Arg 
            20                  25                  30          


Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg 
        35                  40                  45              


Thr Glu Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg 
    50                  55                  60                  


Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Phe Glu Val Arg Val 
65                  70                  75                  80  


Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg 
                85                  90                  95      


Lys Lys Gly Glu Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            100                 105                 110         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu His Tyr Asn 
        115                 120                 125             


Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile 
    130                 135                 140                 


Leu Thr Ile Ile Thr Leu Tyr Met Cys Asn Ser Ser Cys Met Gly Gly 
145                 150                 155                 160 


Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser His 
                165                 170                 175     


Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg 
            180                 185                 190         


Pro Ile Leu Thr Ile Ile Thr Leu Ser Gly Asn Leu Leu Gly Arg Asn 
        195                 200                 205             


Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr 
    210                 215                 220                 


Glu Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg Pro 
225                 230                 235                 240 


Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Asp Arg Asn Thr Phe Arg 
                245                 250                 255     


His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys 
            260                 265                 270         


Thr Thr Ile Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Arg Arg 
        275                 280                 285             


Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser 
    290                 295                 300 


<210>  23
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  24
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
1               5                   10                  15      


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
            20                  25                  30          


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
        35                  40                  45              


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
    50                  55                  60                  


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
65                  70                  75                  80  


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
                85                  90                  95      


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
            100                 105                 110         


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        115                 120                 125             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135         


<210>  25
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  26
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  27
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  27

Tyr Gly Gly Thr Val Asn 
1               5       


<210>  28
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Phe Ser Gly Asp Pro Leu Val 
1               5               


<210>  29
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  29

Cys Ala Val Lys Gly Asp Tyr Lys Leu Ser Phe 
1               5                   10      


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Ser Gly His Ala Thr 
1               5   


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  31

Phe Gln Asn Asn Gly Val 
1               5       


<210>  32
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Ala Ser Ser Leu Val Asn Thr Glu Ala Phe Phe 
1               5                   10          


<210>  33
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Lys Gly Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val 
        115                 120                 125             


Arg Ala 
    130 


<210>  34
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val 
    130     


<210>  35
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Leu Leu Leu Leu Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg 
1               5                   10                  15      


Asp Ala Arg Ala Gln Ser Val Ser Gln His Asn His His Val Ile Leu 
            20                  25                  30          


Ser Glu Ala Ala Ser Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly 
        35                  40                  45              


Thr Val Asn Leu Phe Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg 
                85                  90                  95      


Lys Pro Ser Val Gln Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Lys Gly Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val 
        115                 120                 125             


Arg Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  36
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  37
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  37

Thr Arg Asp Thr Thr Tyr Tyr 
1               5           


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Asn Ser Phe Asp Glu Gln Asn 
1               5               


<210>  39
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  39

Cys Ala Leu Ser Glu Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
1               5                   10                  


<210>  40
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Asn His Asn Val 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  41

Tyr Tyr Asp Lys Asp Phe 
1               5       


<210>  42
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  42

Cys Ala Thr Ser Arg Glu Leu Arg Gly Asn Glu Gln Phe Phe 
1               5                   10                  


<210>  43
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr Leu Leu Thr Val Asn Pro 
    130                 135 


<210>  44
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Arg Glu Leu Arg Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  45
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Leu Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  46
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Arg Glu Leu Arg Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  47
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  47

Thr Ser Gly Phe Asn Gly 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  48

Asn Val Leu Asp Gly Leu 
1               5       


<210>  49
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Ala Val Lys Trp Thr Gly Gly Phe Lys Thr Ile Phe 
1               5                   10              


<210>  50
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asn His Glu Tyr 
1               5   


<210>  51
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Val Gly Ala Gly Ile 
1               5       


<210>  52
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Ala Ser Ser Tyr Arg Glu Ser His Tyr Gly Tyr Thr Phe 
1               5                   10                  


<210>  53
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Lys Trp Thr Gly Gly 
            100                 105                 110         


Phe Lys Thr Ile Phe Gly Ala Gly Thr Arg Leu Phe Val Lys Ala 
        115                 120                 125         


<210>  54
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu 
1               5                   10                  15      


Trp Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln 
            20                  25                  30          


Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met 
        35                  40                  45              


Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu 
    50                  55                  60                  


Arg Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu 
65                  70                  75                  80  


Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro 
                85                  90                  95      


Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys 
            100                 105                 110         


Ala Ser Ser Tyr Arg Glu Ser His Tyr Gly Tyr Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Val 
    130                 


<210>  55
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Trp Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Lys Trp Thr Gly Gly 
            100                 105                 110         


Phe Lys Thr Ile Phe Gly Ala Gly Thr Arg Leu Phe Val Lys Ala Asn 
        115                 120                 125             


Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
    130                 135                 140                 


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
145                 150                 155                 160 


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val 
                165                 170                 175     


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
            180                 185                 190         


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
        195                 200                 205             


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
    210                 215                 220                 


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val 
225                 230                 235                 240 


Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
                245                 250                 255     


Met Thr Leu Arg Leu Trp Ser Ser 
            260                 


<210>  56
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu 
1               5                   10                  15      


Trp Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln 
            20                  25                  30          


Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met 
        35                  40                  45              


Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu 
    50                  55                  60                  


Arg Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu 
65                  70                  75                  80  


Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro 
                85                  90                  95      


Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys 
            100                 105                 110         


Ala Ser Ser Tyr Arg Glu Ser His Tyr Gly Tyr Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  57
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Ser Gly Asn Pro Tyr 
1               5       


<210>  58
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  58

Tyr Ile Thr Gly Asp Asn Leu Val 
1               5               


<210>  59
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  59

Cys Ala Val Arg Val Trp Asp Tyr Lys Leu Ser Phe 
1               5                   10          


<210>  60
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  60

Leu Asn His Asp Ala 
1               5   


<210>  61
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Gln Ile Val Asn Asp 
1               5       


<210>  62
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  62

Cys Ala Ser Ser Ile Ser Ala Gly Gly Asp Gly Tyr Thr Phe 
1               5                   10                  


<210>  63
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Val Trp Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala 
    130     


<210>  64
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  64

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Ser Ala Gly Gly Asp Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val 
    130         


<210>  65
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Val Trp Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  66
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  66

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ile Ser Ala Gly Gly Asp Gly Tyr Thr Phe Gly Ser Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  67
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  67

Asn Ser Ala Ser Gln Ser 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  68

Val Tyr Ser Ser Gly Asn 
1               5       


<210>  69
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  69

Cys Val Val Gln Pro Gly Gly Tyr Gln Lys Val Thr Phe 
1               5                   10              


<210>  70
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asn His Asn Ser 
1               5   


<210>  71
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  71

Ser Ala Ser Glu Gly Thr 
1               5       


<210>  72
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  72

Cys Ala Ser Ser Glu Gly Leu Trp Gln Val Gly Asp Glu Gln Tyr Phe 
1               5                   10                  15      


<210>  73
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Gln 
            100                 105                 110         


Pro Gly Gly Tyr Gln Lys Val Thr Phe Gly Thr Gly Thr Lys Leu Gln 
        115                 120                 125             


Val Ile Pro 
    130     


<210>  74
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Gly Leu Trp Gln Val Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr 
    130                 


<210>  75
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe 
            20                  25                  30          


Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn 
        35                  40                  45              


Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu 
    50                  55                  60                  


Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg 
65                  70                  75                  80  


Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile 
                85                  90                  95      


Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Gln 
            100                 105                 110         


Pro Gly Gly Tyr Gln Lys Val Thr Phe Gly Thr Gly Thr Lys Leu Gln 
        115                 120                 125             


Val Ile Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  76
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Gly Leu Trp Gln Val Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  77
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  77

Thr Ser Glu Asn Asn Tyr Tyr 
1               5           


<210>  78
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Glu Ala Tyr Lys Gln Gln Asn 
1               5               


<210>  79
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  79

Cys Ala Phe Met Gly Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe 
1               5                   10                  15      


<210>  80
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Asn His Arg Tyr 
1               5   


<210>  81
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  81

Ser Tyr Gly Val Lys Asp 
1               5       


<210>  82
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  82

Cys Ala Ile Ser Glu Leu Val Thr Gly Asp Ser Pro Leu His Phe 
1               5                   10                  15  


<210>  83
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Met Gly Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly 
        115                 120                 125             


Lys Gly Thr Lys Leu Ser Val Ile Pro 
    130                 135         


<210>  84
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ala Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Thr 
1               5                   10                  15      


Gly His Met Asp Ala Gly Ile Thr Gln Ser Pro Arg His Lys Val Thr 
            20                  25                  30          


Glu Thr Gly Thr Pro Val Thr Leu Arg Cys His Gln Thr Glu Asn His 
        35                  40                  45              


Arg Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Lys Asp Thr Asp Lys Gly Glu Val Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ser Lys Thr Glu Asp Phe Leu Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Ser Ser Gln Thr Ser Val Tyr Phe Cys Ala Ile 
            100                 105                 110         


Ser Glu Leu Val Thr Gly Asp Ser Pro Leu His Phe Gly Asn Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr 
    130             


<210>  85
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Thr Arg Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu 
1               5                   10                  15      


Glu Ser Gly Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser 
            20                  25                  30          


Val Gln Glu Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Glu Asn Asn Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln 
    50                  55                  60                  


Met Ile Leu Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Asn Arg Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser 
                85                  90                  95      


Leu Lys Ile Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Phe Met Gly Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly 
        115                 120                 125             


Lys Gly Thr Lys Leu Ser Val Ile Pro Asp Ile Gln Asn Pro Glu Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu 
                165                 170                 175     


Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met 
            180                 185                 190         


Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe 
        195                 200                 205             


Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser 
    210                 215                 220                 


Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  86
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ala Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Thr 
1               5                   10                  15      


Gly His Met Asp Ala Gly Ile Thr Gln Ser Pro Arg His Lys Val Thr 
            20                  25                  30          


Glu Thr Gly Thr Pro Val Thr Leu Arg Cys His Gln Thr Glu Asn His 
        35                  40                  45              


Arg Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Lys Asp Thr Asp Lys Gly Glu Val Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ser Lys Thr Glu Asp Phe Leu Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Ser Ser Gln Thr Ser Val Tyr Phe Cys Ala Ile 
            100                 105                 110         


Ser Glu Leu Val Thr Gly Asp Ser Pro Leu His Phe Gly Asn Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  87
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  87

Asn Tyr Ser Pro Ala Tyr 
1               5       


<210>  88
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  88

Ile Arg Glu Asn Glu Lys Glu 
1               5           


<210>  89
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  89

Cys Ala Leu Asp Ile Tyr Pro His Asp Met Arg Phe 
1               5                   10          


<210>  90
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Gly His Ala Thr 
1               5   


<210>  91
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  91

Phe Gln Asn Asn Gly Val 
1               5       


<210>  92
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  92

Cys Ala Ser Ser Leu Asp Pro Gly Asp Thr Gly Glu Leu Phe Phe 
1               5                   10                  15  


<210>  93
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Glu Ser Phe Leu Gly Gly Val Leu Leu Ile Leu Trp Leu Gln Val 
1               5                   10                  15      


Asp Trp Val Lys Ser Gln Lys Ile Glu Gln Asn Ser Glu Ala Leu Asn 
            20                  25                  30          


Ile Gln Glu Gly Lys Thr Ala Thr Leu Thr Cys Asn Tyr Thr Asn Tyr 
        35                  40                  45              


Ser Pro Ala Tyr Leu Gln Trp Tyr Arg Gln Asp Pro Gly Arg Gly Pro 
    50                  55                  60                  


Val Phe Leu Leu Leu Ile Arg Glu Asn Glu Lys Glu Lys Arg Lys Glu 
65                  70                  75                  80  


Arg Leu Lys Val Thr Phe Asp Thr Thr Leu Lys Gln Ser Leu Phe His 
                85                  90                  95      


Ile Thr Ala Ser Gln Pro Ala Asp Ser Ala Thr Tyr Leu Cys Ala Leu 
            100                 105                 110         


Asp Ile Tyr Pro His Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Lys Pro 
    130     


<210>  94
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Asp Pro Gly Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu 
    130                 


<210>  95
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Glu Ser Phe Leu Gly Gly Val Leu Leu Ile Leu Trp Leu Gln Val 
1               5                   10                  15      


Asp Trp Val Lys Ser Gln Lys Ile Glu Gln Asn Ser Glu Ala Leu Asn 
            20                  25                  30          


Ile Gln Glu Gly Lys Thr Ala Thr Leu Thr Cys Asn Tyr Thr Asn Tyr 
        35                  40                  45              


Ser Pro Ala Tyr Leu Gln Trp Tyr Arg Gln Asp Pro Gly Arg Gly Pro 
    50                  55                  60                  


Val Phe Leu Leu Leu Ile Arg Glu Asn Glu Lys Glu Lys Arg Lys Glu 
65                  70                  75                  80  


Arg Leu Lys Val Thr Phe Asp Thr Thr Leu Lys Gln Ser Leu Phe His 
                85                  90                  95      


Ile Thr Ala Ser Gln Pro Ala Asp Ser Ala Thr Tyr Leu Cys Ala Leu 
            100                 105                 110         


Asp Ile Tyr Pro His Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Lys Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  96
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Asp Pro Gly Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  97
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  97

Ser Ser Val Ser Val Tyr 
1               5       


<210>  98
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  98

Tyr Leu Ser Gly Ser Thr Leu Val 
1               5               


<210>  99
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  99

Cys Ala Val Ser Asp Leu Val Arg Asp Asp Lys Ile Ile Phe 
1               5                   10                  


<210>  100
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asn His Asn Ser 
1               5   


<210>  101
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  101

Ser Ala Ser Glu Gly Thr 
1               5       


<210>  102
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  102

Cys Ala Ser Ile Gly Gly Phe Glu Ala Phe Phe 
1               5                   10      


<210>  103
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Asp Leu Val Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg 
        115                 120                 125             


Leu His Ile Leu Pro 
    130             


<210>  104
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  104

Met His Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ile Gly Gly Phe Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val 
    


<210>  105
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Asp Leu Val Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg 
        115                 120                 125             


Leu His Ile Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  106
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  106

Met His Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ile Gly Gly Phe Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300         


<210>  107
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  107

Thr Ser Gly Phe Asn Gly 
1               5       


<210>  108
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  108

Asn Val Leu Asp Gly Leu 
1               5       


<210>  109
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  109

Cys Ala Val Tyr Thr Gly Gly Phe Lys Thr Ile Phe 
1               5                   10          


<210>  110
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  110

Ser Gly His Ala Thr 
1               5   


<210>  111
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  111

Phe Gln Asn Asn Gly Val 
1               5       


<210>  112
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  112

Cys Ala Ser Asn Leu Gly Gly Gly Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  113
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Tyr Thr Gly Gly Phe 
            100                 105                 110         


Lys Thr Ile Phe Gly Ala Gly Thr Arg Leu Phe Val Lys Ala 
        115                 120                 125     


<210>  114
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  114

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Asn Leu Gly Gly Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  115
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Tyr Thr Gly Gly Phe 
            100                 105                 110         


Lys Thr Ile Phe Gly Ala Gly Thr Arg Leu Phe Val Lys Ala Asn Ile 
        115                 120                 125             


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
    130                 135                 140                 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
145                 150                 155                 160 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
            180                 185                 190         


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
        195                 200                 205             


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
    210                 215                 220                 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
225                 230                 235                 240 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
                245                 250                 255     


Thr Leu Arg Leu Trp Ser Ser 
            260             


<210>  116
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  116

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Asn Leu Gly Gly Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  117
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  117

Thr Ser Gly Phe Asn Gly 
1               5       


<210>  118
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  118

Asn Val Leu Asp Gly Leu 
1               5       


<210>  119
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  119

Cys Ala Phe Tyr Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe 
1               5                   10                  


<210>  120
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  120

Ser Gly His Val Ser 
1               5   


<210>  121
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  121

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  122
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  122

Cys Ala Ser Ser Phe Gly Ser Gly Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  123
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Phe Tyr Tyr Gly Gly Ser 
            100                 105                 110         


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
        115                 120                 125             


<210>  124
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  124

Met His Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Phe Gly Ser Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  125
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Phe Tyr Tyr Gly Gly Ser 
            100                 105                 110         


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265 


<210>  126
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  126

Met His Thr Arg Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Ala 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Phe Gly Ser Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  127
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  127

Thr Ser Gly Phe Asn Gly 
1               5       


<210>  128
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  128

Asn Val Leu Asp Gly Leu 
1               5       


<210>  129
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  129

Cys Ala Val Tyr Pro Gly Gly Ser Gln Gly Asn Leu Ile Phe 
1               5                   10                  


<210>  130
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  130

Ser Gly His Ala Thr 
1               5   


<210>  131
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  131

Phe Gln Asn Asn Gly Val 
1               5       


<210>  132
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  132

Cys Ala Ser Ser Leu Gly Thr Gly Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  133
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Tyr Pro Gly Gly Ser 
            100                 105                 110         


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
        115                 120                 125             


<210>  134
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  134

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Thr Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  135
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Tyr Pro Gly Gly Ser 
            100                 105                 110         


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265 


<210>  136
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  136

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Thr Gly Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  137
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  137

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  138
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  138

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  139
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  139

Cys Ala Val Ser Trp Tyr Ser Thr Leu Thr Phe 
1               5                   10      


<210>  140
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  140

Trp Ser His Ser Tyr 
1               5   


<210>  141
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  141

Ser Ala Ala Ala Asp Ile 
1               5       


<210>  142
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  142

Cys Ala Ser Ser Gly Ser Arg Thr Asp Thr Gln Tyr Phe 
1               5                   10              


<210>  143
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Ser Trp Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu Val 
        115                 120                 125             


Ser Pro 
    130 


<210>  144
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  144

Met His Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Ala 
1               5                   10                  15      


Gly His Arg Asp Ala Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr 
            20                  25                  30          


Glu Thr Gly Arg Gln Val Thr Leu Met Cys His Gln Thr Trp Ser His 
        35                  40                  45              


Ser Tyr Met Phe Trp Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Val Val Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Ser Arg Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu 
    130     


<210>  145
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Ser Trp Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu Val 
        115                 120                 125             


Ser Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  146
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  146

Met His Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Ala 
1               5                   10                  15      


Gly His Arg Asp Ala Gly Ile Thr Gln Ser Pro Arg Tyr Lys Ile Thr 
            20                  25                  30          


Glu Thr Gly Arg Gln Val Thr Leu Met Cys His Gln Thr Trp Ser His 
        35                  40                  45              


Ser Tyr Met Phe Trp Tyr Arg Gln Asp Leu Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ala Ala Asp Ile Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Val Val Ser Arg Ser Lys Thr Glu Asn Phe Pro Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Arg Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Gly Ser Arg Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  147
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  147

Ser Val Phe Ser Ser 
1               5   


<210>  148
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  148

Val Val Thr Gly Gly Glu Val 
1               5           


<210>  149
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  149

Cys Ala Gly Glu Phe Ala Gly Asn Gln Phe Tyr Phe 
1               5                   10          


<210>  150
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Gly His Arg Ala 
1               5   


<210>  151
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  151

Tyr Ser Tyr Glu Lys Leu 
1               5       


<210>  152
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  152

Cys Ala Ser Ser Gln Val Gly Leu Thr Tyr Glu Gln Tyr Phe 
1               5                   10                  


<210>  153
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Ala Leu Lys Phe Ser Val Ser Ile Leu Trp Ile Gln Leu Ala Trp 
1               5                   10                  15      


Val Ser Thr Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln 
            20                  25                  30          


Glu Gly Glu Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser 
        35                  40                  45              


Ser Leu Gln Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Val Thr Val Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Ala Gln Pro Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Glu Phe Ala 
            100                 105                 110         


Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro 
        115                 120                 125             


<210>  154
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  154

Met His Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Ile Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His 
        35                  40                  45              


Arg Ala Met Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His 
                85                  90                  95      


Leu His Ala Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Val Gly Leu Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr 
    130         


<210>  155
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Ala Leu Lys Phe Ser Val Ser Ile Leu Trp Ile Gln Leu Ala Trp 
1               5                   10                  15      


Val Ser Thr Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln 
            20                  25                  30          


Glu Gly Glu Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser 
        35                  40                  45              


Ser Leu Gln Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Val Thr Val Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Ala Gln Pro Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Glu Phe Ala 
            100                 105                 110         


Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265 


<210>  156
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  156

Met His Cys Arg Leu Leu Cys Cys Ala Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Val Pro Ile Asp Thr Glu Val Thr Gln Thr Pro Lys His Leu Val Met 
            20                  25                  30          


Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln His Met Gly His 
        35                  40                  45              


Arg Ala Met Tyr Trp Tyr Lys Gln Lys Ala Lys Lys Pro Pro Glu Leu 
    50                  55                  60                  


Met Phe Val Tyr Ser Tyr Glu Lys Leu Ser Ile Asn Glu Ser Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser Leu Leu Asn Leu His 
                85                  90                  95      


Leu His Ala Leu Gln Pro Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gln Val Gly Leu Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  157
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  157

Val Ser Gly Asn Pro Tyr 
1               5       


<210>  158
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  158

Tyr Ile Thr Gly Asp Asn Leu Val 
1               5               


<210>  159
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  159

Cys Ala Val Arg Asp Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
1               5                   10                  15      


<210>  160
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  160

Ser Gly His Ala Thr 
1               5   


<210>  161
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  161

Phe Gln Asn Asn Gly Val 
1               5       


<210>  162
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  162

Cys Ala Ser Ser Leu Gly Gln Gly Gln Thr Gln Tyr Phe 
1               5                   10              


<210>  163
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr Leu Leu Thr Val Asn Pro 
    130                 135 


<210>  164
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  164

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gln Gly Gln Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Leu Val Leu 
    130         


<210>  165
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  166
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  166

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Gln Gly Gln Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  167
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  167

Ser Ser Val Ser Val Tyr 
1               5       


<210>  168
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  168

Tyr Leu Ser Gly Ser Thr Leu Val 
1               5               


<210>  169
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  169

Cys Ala Val Arg Gly Ser Ser Gly Thr Tyr Lys Tyr Ile Phe 
1               5                   10                  


<210>  170
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Asp His Glu Asn 
1               5   


<210>  171
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  171

Ser Tyr Asp Val Lys Met 
1               5       


<210>  172
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  172

Cys Ala Ser Lys Gly Asp Gln Asn Thr Glu Ala Phe Phe 
1               5                   10              


<210>  173
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Gly Ser Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg 
        115                 120                 125             


Leu Lys Val Leu Ala 
    130             


<210>  174
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  174

Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Lys Gly Asp Gln Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val 
    130     


<210>  175
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Gly Ser Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg 
        115                 120                 125             


Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  176
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  176

Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Lys Gly Asp Gln Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  177
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  177

Thr Ser Gly Phe Asn Gly 
1               5       


<210>  178
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  178

Asn Val Leu Asp Gly Leu 
1               5       


<210>  179
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  179

Cys Ala Val Arg Asp Leu Gln Thr Gly Ala Asn Asn Leu Phe Phe 
1               5                   10                  15  


<210>  180
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Asp His Glu Asn 
1               5   


<210>  181
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  181

Ser Tyr Asp Val Lys Met 
1               5       


<210>  182
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  182

Cys Ala Ser Ser Leu Thr Phe Gly Thr Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  183
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Arg Asp Leu Gln Thr 
            100                 105                 110         


Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu Thr Val Ile 
        115                 120                 125             


Pro 
    


<210>  184
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  184

Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Thr Phe Gly Thr Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val 
    130         


<210>  185
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Arg Asp Leu Gln Thr 
            100                 105                 110         


Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu Thr Val Ile 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
    130                 135                 140                 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
                165                 170                 175     


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
            180                 185                 190         


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
        195                 200                 205             


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
    210                 215                 220                 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265     


<210>  186
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  186

Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Leu Thr Phe Gly Thr Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  187
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  187

Val Thr Asn Phe Arg Ser 
1               5       


<210>  188
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  188

Leu Thr Ser Ser Gly Ile Glu 
1               5           


<210>  189
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  189

Cys Ala Gly Gln Asn Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe 
1               5                   10                  15  


<210>  190
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  190

Ser Asn His Leu Tyr 
1               5   


<210>  191
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  191

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  192
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  192

Cys Ala Ser Arg Asp Pro Ala Tyr Glu Gln Tyr Phe 
1               5                   10          


<210>  193
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Ala Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Ser Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Ile Tyr Leu Cys Ala Gly 
            100                 105                 110         


Gln Asn Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Lys Pro 
    130                 


<210>  194
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  194

Met His Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Asp Pro Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr 
    130     


<210>  195
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Ala Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Ser Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Ile Tyr Leu Cys Ala Gly 
            100                 105                 110         


Gln Asn Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  196
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  196

Met His Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Arg Asp Pro Ala Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  197
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  197

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  198
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  198

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  199
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  199

Cys Ala Val Asn Pro Pro Val Lys Thr Ser Tyr Asp Lys Val Ile Phe 
1               5                   10                  15      


<210>  200
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  200

Ser Gly His Val Ser 
1               5   


<210>  201
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  201

Phe Asn Tyr Glu Ala Gln 
1               5       


<210>  202
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  202

Cys Ala Ser Ser His Arg Glu Pro His Thr Gly Glu Leu Phe Phe 
1               5                   10                  15  


<210>  203
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Pro Pro Val Lys Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro Gly 
        115                 120                 125             


Thr Ser Leu Ser Val Ile Pro 
    130                 135 


<210>  204
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  204

Met His Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala 
            100                 105                 110         


Ser Ser His Arg Glu Pro His Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu 
    130                 


<210>  205
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Pro Pro Val Lys Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro Gly 
        115                 120                 125             


Thr Ser Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  206
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  206

Met His Thr Ser Leu Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr 
            20                  25                  30          


Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Val Ser Leu Tyr Trp Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Asn Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Ser Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala 
            100                 105                 110         


Ser Ser His Arg Glu Pro His Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  207
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  207

Thr Arg Asp Thr Thr Tyr Tyr 
1               5           


<210>  208
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  208

Arg Asn Ser Phe Asp Glu Gln Asn 
1               5               


<210>  209
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  209

Cys Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10                  15  


<210>  210
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  210

Ser Gly Asp Leu Ser 
1               5   


<210>  211
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  211

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  212
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  212

Cys Ala Ser Ser Val Gly Ser Ser Ser Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  213
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  213

Met Ala Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala 
    130                 135     


<210>  214
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  214

Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Gly Ser Ser Ser Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  215
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  215

Met Ala Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  216
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  216

Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Gly Ser Ser Ser Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  217
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  217

Thr Arg Asp Thr Thr Tyr Tyr 
1               5           


<210>  218
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  218

Arg Asn Ser Phe Asp Glu Gln Asn 
1               5               


<210>  219
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  219

Cys Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10                  15  


<210>  220
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  220

Ser Gly Asp Leu Ser 
1               5   


<210>  221
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  221

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  222
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  222

Cys Ala Ser Ser Val Gly Ser Ser Ser Ser Thr Asp Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  223
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  223

Met Ala Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala 
    130                 135     


<210>  224
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  224

Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile His Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Gly Ser Ser Ser Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  225
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  225

Met Ala Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  226
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  226

Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile His Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Val Gly Ser Ser Ser Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  227
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  227

Asn Ser Ala Phe Gln Tyr 
1               5       


<210>  228
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  228

Thr Tyr Ser Ser Gly Asn 
1               5       


<210>  229
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  229

Cys Ala Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe 
1               5                   10                  


<210>  230
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  230

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  231
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  231

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  232
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  232

Cys Ser Gly Gly Leu Glu Glu Ala Ala Arg Gln Phe Ile 
1               5                   10              


<210>  233
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  233

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro 
    130                 


<210>  234
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  234

Met His Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Gly Gly Leu Glu Glu Ala Ala Arg 
        115                 120                 125             


Gln Phe Ile Gly Pro Gly Thr Arg Leu Thr Val Leu 
    130                 135                 140 


<210>  235
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  235

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  236
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  236

Met His Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Gly Gly Leu Glu Glu Ala Ala Arg 
        115                 120                 125             


Gln Phe Ile Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  237
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  237

Asn Ser Ala Phe Gln Tyr 
1               5       


<210>  238
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  238

Thr Tyr Ser Ser Gly Asn 
1               5       


<210>  239
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  239

Cys Ala Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe 
1               5                   10                  


<210>  240
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  240

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  241
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  241

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  242
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  242

Cys Ser Gly Gly Leu Glu Glu Ala Ala Arg Gln Phe Ile 
1               5                   10              


<210>  243
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro 
    130                 


<210>  244
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  244

Met His Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly 
1               5                   10                  15      


Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr 
            20                  25                  30          


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
        35                  40                  45              


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
    50                  55                  60                  


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
65                  70                  75                  80  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
                85                  90                  95      


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Gly Gly 
            100                 105                 110         


Leu Glu Glu Ala Ala Arg Gln Phe Ile Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Leu 
    130 


<210>  245
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  245

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  246
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  246

Met His Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly 
1               5                   10                  15      


Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr 
            20                  25                  30          


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
        35                  40                  45              


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
    50                  55                  60                  


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
65                  70                  75                  80  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
                85                  90                  95      


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Gly Gly 
            100                 105                 110         


Leu Glu Glu Ala Ala Arg Gln Phe Ile Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  247
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  247

Thr Ile Ser Gly Asn Glu Tyr 
1               5           


<210>  248
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  248

Gly Leu Lys Asn Asn 
1               5   


<210>  249
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  249

Cys Ile Val Pro Asn Asp Tyr Lys Leu Ser Phe 
1               5                   10      


<210>  250
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  250

Met Asp His Glu Asn 
1               5   


<210>  251
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  251

Ser Tyr Asp Val Lys Met 
1               5       


<210>  252
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  252

Cys Ala Ser Ser Phe Gly Thr Gly Ser Ile Gln Glu Thr Gln Tyr Phe 
1               5                   10                  15      


<210>  253
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  253

Met Ala Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Pro Asn Asp Tyr Lys 
            100                 105                 110         


Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala 
        115                 120                 125 


<210>  254
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  254

Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Gly Thr Gly Ser Ile Gln Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu 
    130                 


<210>  255
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  255

Met Ala Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Pro Asn Asp Tyr Lys 
            100                 105                 110         


Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn Ile Gln 
        115                 120                 125             


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
    130                 135                 140                 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
145                 150                 155                 160 


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
                165                 170                 175     


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
            180                 185                 190         


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
        195                 200                 205             


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
    210                 215                 220                 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
225                 230                 235                 240 


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
                245                 250                 255     


Leu Arg Leu Trp Ser Ser 
            260         


<210>  256
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  256

Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala Val 
1               5                   10                  15      


Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val Lys 
            20                  25                  30          


Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp His 
        35                  40                  45              


Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile Pro 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu Ile 
                85                  90                  95      


Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Phe Gly Thr Gly Ser Ile Gln Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  257
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  257

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  258
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  258

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  259
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  259

Cys Ala Leu Asn Pro Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  260
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  260

Ser Gly His Thr Ser 
1               5   


<210>  261
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  261

Tyr Asp Glu Gly Glu Glu 
1               5       


<210>  262
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  262

Cys Ala Ser Ser Ser Pro Gly Ala Thr Ser Gly Gly Ala Asn Thr Gly 
1               5                   10                  15      


Glu Leu Phe Phe 
            20  


<210>  263
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  263

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Asn 
            100                 105                 110         


Pro Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Ile Leu Thr Val His Pro 
    130                 135 


<210>  264
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  264

Met His Pro Arg Leu Leu Phe Trp Ala Leu Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly Pro Val Glu Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Ala Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ser Val Tyr Trp Tyr Gln Gln Ala Leu Gly Leu Gly Leu Gln Phe 
    50                  55                  60                  


Leu Leu Trp Tyr Asp Glu Gly Glu Glu Arg Asn Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Glu Leu Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Pro Gly Ala Thr Ser Gly Gly Ala Asn Thr Gly Glu Leu Phe 
        115                 120                 125             


Phe Gly Glu Gly Ser Arg Leu Thr Val Leu 
    130                 135             


<210>  265
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  265

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Asn 
            100                 105                 110         


Pro Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  266
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  266

Met His Pro Arg Leu Leu Phe Trp Ala Leu Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly Pro Val Glu Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Ala Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ser Val Tyr Trp Tyr Gln Gln Ala Leu Gly Leu Gly Leu Gln Phe 
    50                  55                  60                  


Leu Leu Trp Tyr Asp Glu Gly Glu Glu Arg Asn Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Pro Arg Phe Ser Gly Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Glu Leu Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Pro Gly Ala Thr Ser Gly Gly Ala Asn Thr Gly Glu Leu Phe 
        115                 120                 125             


Phe Gly Glu Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val 
    130                 135                 140                 


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
145                 150                 155                 160 


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
                165                 170                 175     


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
            180                 185                 190         


Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
225                 230                 235                 240 


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
            260                 265                 270         


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala 
    290                 295                 300                 


Met Val Lys Arg Lys Asn Ser 
305                 310     


<210>  267
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  267

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  268
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  268

Ile Phe Ser Asn Met Asp Met 
1               5           


<210>  269
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  269

Cys Ala Glu Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  270
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  270

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  271
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  271

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  272
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  272

Cys Ser Ala Arg Asp Leu Gln Arg Ser Tyr Glu Gln Tyr Phe 
1               5                   10                  


<210>  273
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  273

Met Ala Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro 
    130                 135     


<210>  274
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  274

Met His Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp Leu Gln Arg Ser Tyr 
        115                 120                 125             


Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr 
    130                 135                 140     


<210>  275
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  275

Met Ala Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  276
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  276

Met His Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp Leu Gln Arg Ser Tyr 
        115                 120                 125             


Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu 
    130                 135                 140                 


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
145                 150                 155                 160 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
                165                 170                 175     


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
            180                 185                 190         


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
        195                 200                 205             


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    210                 215                 220                 


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
225                 230                 235                 240 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
                245                 250                 255     


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
            260                 265                 270         


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        275                 280                 285             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
    290                 295                 300                 


Val Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310                 


<210>  277
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  277

Asp Ser Ser Ser Thr Tyr 
1               5       


<210>  278
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  278

Ile Phe Ser Asn Met Asp Met 
1               5           


<210>  279
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  279

Cys Ala Glu Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10                  15      


Phe 
    


<210>  280
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  280

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  281
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  281

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  282
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  282

Cys Ser Ala Arg Asp Leu Gln Arg Ser Tyr Glu Gln Tyr Phe 
1               5                   10                  


<210>  283
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Ala Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro 
    130                 135     


<210>  284
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  284

Met His Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly 
1               5                   10                  15      


Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr 
            20                  25                  30          


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
        35                  40                  45              


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
    50                  55                  60                  


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
65                  70                  75                  80  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
                85                  90                  95      


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg 
            100                 105                 110         


Asp Leu Gln Arg Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr 
    130     


<210>  285
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Ala Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  286
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  286

Met His Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly 
1               5                   10                  15      


Ala Val Val Ser Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr 
            20                  25                  30          


Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met 
        35                  40                  45              


Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr 
    50                  55                  60                  


Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp 
65                  70                  75                  80  


Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val 
                85                  90                  95      


Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg 
            100                 105                 110         


Asp Leu Gln Arg Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


<210>  287
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  287

Asn Ser Ala Ser Asp Tyr 
1               5       


<210>  288
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  288

Ile Arg Ser Asn Met Asp Lys 
1               5           


<210>  289
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  289

Cys Ala Glu Pro Val Gly Gly Leu Asn Ser Gly Tyr Ala Leu Asn Phe 
1               5                   10                  15      


<210>  290
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  290

Ser Gly His Lys Ser 
1               5   


<210>  291
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  291

Tyr Tyr Glu Lys Glu Glu 
1               5       


<210>  292
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  292

Cys Ala Ser Ser Gly Gly Arg Thr Ser Gly Ala Tyr Glu Gln Phe Phe 
1               5                   10                  15      


<210>  293
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Pro Val Gly Gly Leu Asn Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly 
        115                 120                 125             


Thr Ser Leu Leu Val Thr Pro 
    130                 135 


<210>  294
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  294

Met His Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Lys Ser Val Ser Trp Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Arg Thr Ser Gly Ala Tyr Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  295
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  295

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Pro Val Gly Gly Leu Asn Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly 
        115                 120                 125             


Thr Ser Leu Leu Val Thr Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


<210>  296
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  296

Met His Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His 
        35                  40                  45              


Lys Ser Val Ser Trp Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Ala Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Gly Gly Arg Thr Ser Gly Ala Tyr Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  297
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  297

Val Ser Gly Leu Arg Gly 
1               5       


<210>  298
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  298

Leu Tyr Ser Ala Gly Glu Glu 
1               5           


<210>  299
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  299

Cys Ala Val Thr Ala His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe 
1               5                   10                  15      


<210>  300
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  300

Ser Gly His Asp Thr 
1               5   


<210>  301
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  301

Tyr Tyr Glu Glu Glu Glu 
1               5       


<210>  302
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  302

Cys Ala Ser Ser Arg Arg Gly Gly Ala Tyr Asn Glu Gln Phe Phe 
1               5                   10                  15  


<210>  303
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  303

Met Ala Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr 
            100                 105                 110         


Ala His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr 
        115                 120                 125             


Gln Leu Thr Val Trp Pro 
    130                 


<210>  304
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  304

Met His Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Arg Gly Gly Ala Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu 
    130             


<210>  305
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  305

Met Ala Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr 
            100                 105                 110         


Ala His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr 
        115                 120                 125             


Gln Leu Thr Val Trp Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  306
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  306

Met His Pro Gly Leu Leu Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Leu Val Asp Ala Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys 
            20                  25                  30          


Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Pro Lys Ser Gly His 
        35                  40                  45              


Asp Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe 
    50                  55                  60                  


Ile Phe Gln Tyr Tyr Glu Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro 
65                  70                  75                  80  


Asp Arg Phe Ser Gly His Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn 
                85                  90                  95      


Val Asn Ala Leu Leu Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Arg Arg Gly Gly Ala Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  307
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  307

Ser Ser Asn Phe Tyr Ala 
1               5       


<210>  308
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  308

Met Thr Leu Asn Gly Asp Glu 
1               5           


<210>  309
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  309

Cys Ala Ser Val Gly Gly Gly Ala Asp Gly Leu Thr Phe 
1               5                   10              


<210>  310
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  310

Ser Gly His Thr Ala 
1               5   


<210>  311
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  311

Phe Gln Gly Asn Ser Ala 
1               5       


<210>  312
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  312

Cys Ala Ser Thr Trp Asp Arg Gly Ser Tyr Asn Glu Gln Phe Phe 
1               5                   10                  15  


<210>  313
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  313

Met Ala Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Ser Val Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


His Leu Ile Ile Gln Pro 
    130                 


<210>  314
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  314

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Thr Trp Asp Arg Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu 
    130                 


<210>  315
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  315

Met Ala Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Ser Val Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


His Leu Ile Ile Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  316
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  316

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Thr Trp Asp Arg Gly Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  317
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  317

Asn Ser Met Phe Asp Tyr 
1               5       


<210>  318
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  318

Ile Ser Ser Ile Lys Asp Lys 
1               5           


<210>  319
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  319

Cys Ala Ala Asn Thr Gly Asn Gln Phe Tyr Phe 
1               5                   10      


<210>  320
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  320

Ser Gly His Ala Thr 
1               5   


<210>  321
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  321

Phe Gln Asn Asn Gly Val 
1               5       


<210>  322
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  322

Cys Ala Ser Ser His Leu Ala Gly Glu Phe Tyr Asn Glu Gln Phe Phe 
1               5                   10                  15      


<210>  323
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  323

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Asn Thr Gly Asn Gln Phe Tyr Phe Gly Thr 
        115                 120                 125             


Gly Thr Ser Leu Thr Val Ile Pro 
    130                 135     


<210>  324
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  324

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser His Leu Ala Gly Glu Phe Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu 
    130                 135 


<210>  325
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  325

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Asn Thr Gly Asn Gln Phe Tyr Phe Gly Thr 
        115                 120                 125             


Gly Thr Ser Leu Thr Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser 
    


<210>  326
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  326

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser His Leu Ala Gly Glu Phe Tyr Asn Glu Gln Phe Phe Gly Pro 
        115                 120                 125             


Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
            180                 185                 190         


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
            260                 265                 270         


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
    290                 295                 300                 


Arg Lys Asn Ser 
305             


<210>  327
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  327

Thr Ser Gly Phe Tyr Gly 
1               5       


<210>  328
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  328

Asn Ala Leu Asp Gly Leu 
1               5       


<210>  329
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  329

Cys Ala Phe Ala Tyr Gly Gln Asn Phe Val Phe 
1               5                   10      


<210>  330
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  330

Ser Gly Asp Leu Ser 
1               5   


<210>  331
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  331

Tyr Tyr Asn Gly Glu Glu 
1               5       


<210>  332
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  332

Cys Ala Ser Ser Pro Leu Gly Asp Ser Gly Asn Thr Ile Tyr Phe 
1               5                   10                  15  


<210>  333
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Ala Gly Ala Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Ala Gly Gln Ser Leu Glu Gln Pro Ser Glu Val Thr Ala Val Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Tyr Gly 
        35                  40                  45              


Leu Ser Trp Tyr Gln Gln His Asp Gly Gly Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Ala Leu Asp Gly Leu Glu Glu Thr Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Asp Ser Tyr Gly Tyr Leu Leu Leu Gln Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Phe Cys Ala Phe Ala Tyr Gly Gln Asn 
            100                 105                 110         


Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu Pro 
        115                 120                 125 


<210>  334
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  334

Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Leu Gly Asp Ser Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser 
        115                 120                 125             


Trp Leu Thr Val Val 
    130             


<210>  335
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Ala Gly Ala Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Ala Gly Gln Ser Leu Glu Gln Pro Ser Glu Val Thr Ala Val Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Tyr Gly 
        35                  40                  45              


Leu Ser Trp Tyr Gln Gln His Asp Gly Gly Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Ala Leu Asp Gly Leu Glu Glu Thr Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Asp Ser Tyr Gly Tyr Leu Leu Leu Gln Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Phe Cys Ala Phe Ala Tyr Gly Gln Asn 
            100                 105                 110         


Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu Pro Asn Ile Gln 
        115                 120                 125             


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
    130                 135                 140                 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
145                 150                 155                 160 


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
                165                 170                 175     


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
            180                 185                 190         


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
        195                 200                 205             


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
    210                 215                 220                 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
225                 230                 235                 240 


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
                245                 250                 255     


Leu Arg Leu Trp Ser Ser 
            260         


<210>  336
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  336

Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr 
            20                  25                  30          


Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp 
        35                  40                  45              


Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe 
    50                  55                  60                  


Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu 
65                  70                  75                  80  


Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn 
                85                  90                  95      


Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Pro Leu Gly Asp Ser Gly Asn Thr Ile Tyr Phe Gly Glu Gly Ser 
        115                 120                 125             


Trp Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  337
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  337

Thr Ser Ile Asn Asn 
1               5   


<210>  338
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  338

Ile Arg Ser Asn Glu Arg Glu 
1               5           


<210>  339
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  339

Cys Ala Thr Asp Ala Trp Asn Asn Asp Met Arg Phe 
1               5                   10          


<210>  340
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  340

Met Asn His Asn Ser 
1               5   


<210>  341
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  341

Ser Ala Ser Glu Gly Thr 
1               5       


<210>  342
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  342

Cys Ala Ser Ser Glu Ser Gln Gly Asn Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  343
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  343

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Ala Trp Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Lys Pro 
    130 


<210>  344
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  344

Met His Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Ser Gln Gly Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val 
    130         


<210>  345
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  345

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Ala Trp Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  346
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  346

Met His Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Ser Gln Gly Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  347
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  347

Val Ser Pro Phe Ser Asn 
1               5       


<210>  348
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  348

Met Thr Phe Ser Glu Asn Thr 
1               5           


<210>  349
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  349

Cys Val Val Ser Ser Tyr Lys Ile Ile Phe 
1               5                   10  


<210>  350
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  350

Ser Gly His Thr Ala 
1               5   


<210>  351
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  351

Phe Gln Gly Asn Ser Ala 
1               5       


<210>  352
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  352

Cys Ala Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro Leu His Phe 
1               5                   10                  15  


<210>  353
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  353

Met Ala Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ser Tyr Lys Ile Ile Phe Gly Thr Gly Thr Arg Leu His Val 
        115                 120                 125             


Phe Pro 
    130 


<210>  354
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  354

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Tyr His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Glu Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr 
    130                 


<210>  355
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  355

Met Ala Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ser Tyr Lys Ile Ile Phe Gly Thr Gly Thr Arg Leu His Val 
        115                 120                 125             


Phe Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  356
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  356

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Tyr His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Glu Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  357
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  357

Val Ser Pro Phe Ser Asn 
1               5       


<210>  358
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  358

Met Thr Phe Ser Glu Asn Thr 
1               5           


<210>  359
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  359

Ile Cys Val Val Ser Ser Tyr Lys Leu Ile Phe 
1               5                   10      


<210>  360
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  360

Ser Gly His Thr Ala 
1               5   


<210>  361
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  361

Phe Gln Gly Asn Ser Ala 
1               5       


<210>  362
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  362

Cys Ala Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro Leu His Phe 
1               5                   10                  15  


<210>  363
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  363

Met Ala Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ser Tyr Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val 
        115                 120                 125             


Phe Pro 
    130 


<210>  364
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  364

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Tyr His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Glu Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr 
    130                 


<210>  365
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  365

Met Ala Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ser Tyr Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val 
        115                 120                 125             


Phe Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  366
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  366

Met His Thr Arg Leu Leu Phe Trp Val Ala Phe Cys Leu Leu Gly Ala 
1               5                   10                  15      


Tyr His Thr Gly Ala Gly Val Ser Gln Ser Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Asp Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu Gly Gln Gly Leu Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly Glu Ser Val Ser Thr Leu 
                85                  90                  95      


Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro Leu His Phe Gly Asn Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  367
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  367

Ser Ser Val Ser Val Tyr 
1               5       


<210>  368
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  368

Tyr Leu Ser Gly Ser Thr Leu Val 
1               5               


<210>  369
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  369

Cys Ala Val Ser Lys Gly Thr Gly Ala Gln Lys Leu Val Phe 
1               5                   10                  


<210>  370
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  370

Leu Asn His Asp Ala 
1               5   


<210>  371
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  371

Ser Gln Ile Val Asn Asp 
1               5       


<210>  372
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  372

Cys Ala Ser Glu Ala Phe Phe 
1               5           


<210>  373
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  373

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Lys Gly Thr Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Ile Asn Pro 
    130             


<210>  374
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  374

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Ile 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Ser Tyr Leu Cys Ala Ser 
            100                 105                 110         


Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
        115                 120                 125 


<210>  375
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  375

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Lys Gly Thr Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Ile Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  376
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  376

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Ala 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Ile 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Ser Tyr Leu Cys Ala Ser 
            100                 105                 110         


Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu 
        115                 120                 125             


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
    130                 135                 140                 


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
145                 150                 155                 160 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
                165                 170                 175     


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
            180                 185                 190         


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
        195                 200                 205             


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
    210                 215                 220                 


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
225                 230                 235                 240 


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
                245                 250                 255     


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
            260                 265                 270         


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
        275                 280                 285             


Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295             


<210>  377
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  377

Thr Ile Ser Gly Thr Asp Tyr 
1               5           


<210>  378
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  378

Gly Leu Thr Ser Asn 
1               5   


<210>  379
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  379

Cys Ile Leu Ala Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe 
1               5                   10                  


<210>  380
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  380

Leu Gly His Asp Thr 
1               5   


<210>  381
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  381

Tyr Asn Asn Lys Glu Leu 
1               5       


<210>  382
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  382

Cys Ala Ser Arg Thr Ile Gly Tyr Asn Thr Glu Ala Phe Phe 
1               5                   10                  


<210>  383
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  383

Met Ala Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Ala Ser Gly Ala Gly 
            100                 105                 110         


Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile Pro 
        115                 120                 125             


<210>  384
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  384

Met His Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Arg Thr Ile Gly Tyr Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val 
    130         


<210>  385
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  385

Met Ala Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Ala Ser Gly Ala Gly 
            100                 105                 110         


Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265 


<210>  386
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  386

Met His Cys Arg Leu Leu Cys Cys Val Val Phe Cys Leu Leu Gln Ala 
1               5                   10                  15      


Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys Tyr Leu Val Thr 
            20                  25                  30          


Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln Asn Leu Gly His 
        35                  40                  45              


Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys Phe Leu Lys Ile 
    50                  55                  60                  


Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn Glu Thr Val Pro 
65                  70                  75                  80  


Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His Leu Asn Leu His 
                85                  90                  95      


Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Arg Thr Ile Gly Tyr Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  387
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  387

Val Gly Ile Ser Ala 
1               5   


<210>  388
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  388

Leu Ser Ser Gly Lys 
1               5   


<210>  389
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  389

Cys Ala Ala Leu Ser Tyr Asn Thr Asp Lys Leu Ile Phe 
1               5                   10              


<210>  390
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  390

Ser Gly His Thr Ala 
1               5   


<210>  391
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  391

Phe Gln Gly Thr Gly Ala 
1               5       


<210>  392
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  392

Cys Ala Ser Ser Leu Ser Gly Leu Leu Gln Glu Thr Gln Tyr Phe 
1               5                   10                  15  


<210>  393
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  393

Met Ala Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Ala Leu 
            100                 105                 110         


Ser Tyr Asn Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln 
        115                 120                 125             


Val Phe Pro 
    130     


<210>  394
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  394

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Ser Gly Leu Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu 
    130                 


<210>  395
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  395

Met Ala Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Ala Leu 
            100                 105                 110         


Ser Tyr Asn Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln 
        115                 120                 125             


Val Phe Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  396
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  396

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Thr Gly Ala Gly Val Ser Gln Thr Pro Ser Asn Lys Val Thr 
            20                  25                  30          


Glu Lys Gly Lys Tyr Val Glu Leu Arg Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Thr Ala Leu Tyr Trp Tyr Arg Gln Ser Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Ile Tyr Phe Gln Gly Thr Gly Ala Ala Asp Asp Ser Gly Leu Pro 
65                  70                  75                  80  


Asn Asp Arg Phe Phe Ala Val Arg Pro Glu Gly Ser Val Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Arg Thr Glu Arg Gly Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Ser Gly Leu Leu Gln Glu Thr Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  397
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  397

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  398
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  398

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  399
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  399

Cys Ala Leu Ser His Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe 
1               5                   10                  15      


<210>  400
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  400

Ser Gly His Ala Thr 
1               5   


<210>  401
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  401

Phe Gln Asn Asn Gly Val 
1               5       


<210>  402
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  402

Cys Ala Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe 
1               5                   10                  15  


<210>  403
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  403

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


His Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro 
    130                 


<210>  404
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  404

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu 
    130                 


<210>  405
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  405

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


His Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  406
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  406

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  407
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  407

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  408
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  408

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  409
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  409

Cys Ala Leu Ser Gln Thr Gly Ser Ser Lys Thr Gly Lys Leu Ile Phe 
1               5                   10                  15      


<210>  410
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  410

Ser Gly His Ala Thr 
1               5   


<210>  411
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  411

Phe Gln Asn Asn Gly Val 
1               5       


<210>  412
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  412

Cys Ala Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe 
1               5                   10                  15  


<210>  413
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  413

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Gln Thr Gly Ser Ser Lys Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro 
    130                 


<210>  414
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  414

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu 
    130                 


<210>  415
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  415

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Gln Thr Gly Ser Ser Lys Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  416
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  416

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  417
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  417

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  418
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  418

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  419
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  419

Cys Ala Leu Ser Gln Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe 
1               5                   10                  15      


<210>  420
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  420

Ser Gly His Ala Thr 
1               5   


<210>  421
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  421

Phe Gln Asn Asn Gly Val 
1               5       


<210>  422
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  422

Cys Ala Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe 
1               5                   10                  15  


<210>  423
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  423

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Gln Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro 
    130                 


<210>  424
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  424

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu 
    130                 


<210>  425
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  425

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Gln Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  426
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  426

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  427
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  427

Ala Thr Gly Tyr Pro Ser 
1               5       


<210>  428
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  428

Ala Thr Lys Ala Asp Asp Lys 
1               5           


<210>  429
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  429

Cys Ala Leu Ser Thr Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe 
1               5                   10                  15      


<210>  430
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  430

Ser Gly His Ala Thr 
1               5   


<210>  431
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  431

Phe Gln Asn Asn Gly Val 
1               5       


<210>  432
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  432

Cys Ala Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe 
1               5                   10                  15  


<210>  433
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  433

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Thr Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Gln Val Lys Pro 
    130                 


<210>  434
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  434

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu 
    130                 


<210>  435
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  435

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Thr Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  436
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  436

Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Thr Gly Gly Gly Arg His Gln Pro Gln His Phe Gly Asp Gly 
        115                 120                 125             


Thr Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser 
305         


<210>  437
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  437

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  438
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  438

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  439
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  439

Cys Ala Val Thr Leu Cys Gly Gly Tyr Asn Lys Leu Ile Phe 
1               5                   10                  


<210>  440
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  440

Leu Asn His Asp Ala 
1               5   


<210>  441
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  441

Ser Gln Ile Val Asn Asp 
1               5       


<210>  442
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  442

Cys Ala Ser Ser Ser Arg Asp Tyr Glu Gln Tyr Phe 
1               5                   10          


<210>  443
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  443

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Thr Leu Cys Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ala Val His Pro 
    130             


<210>  444
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  444

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Val 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Arg Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Thr 
    130 


<210>  445
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  445

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Thr Leu Cys Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ala Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  446
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  446

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Val 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Arg Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  447
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  447

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  448
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  448

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  449
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  449

Cys Ala Val Thr Leu Ser Gly Gly Tyr Asn Lys Leu Ile Phe 
1               5                   10                  


<210>  450
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  450

Leu Asn His Asp Ala 
1               5   


<210>  451
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  451

Ser Gln Ile Val Asn Asp 
1               5       


<210>  452
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  452

Cys Ala Ser Ser Ser Arg Asp Tyr Glu Gln Tyr Phe 
1               5                   10          


<210>  453
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  453

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Thr Leu Ser Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ala Val His Pro 
    130             


<210>  454
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  454

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Val 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Arg Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Thr 
    130 


<210>  455
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  455

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Thr Leu Ser Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ala Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  456
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  456

Met His Asn Gln Val Leu Cys Cys Val Val Leu Cys Phe Leu Gly Ala 
1               5                   10                  15      


Asn Thr Val Asp Gly Gly Ile Thr Gln Ser Pro Lys Tyr Leu Phe Arg 
            20                  25                  30          


Lys Glu Gly Gln Asn Val Thr Leu Ser Cys Glu Gln Asn Leu Asn His 
        35                  40                  45              


Asp Ala Met Tyr Trp Tyr Arg Gln Asp Pro Gly Gln Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Gln Ile Val Asn Asp Phe Gln Lys Gly Asp Ile Val 
65                  70                  75                  80  


Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Ser Phe Pro Leu Thr 
                85                  90                  95      


Val Thr Ser Ala Gln Lys Asn Pro Thr Ala Phe Tyr Leu Cys Ala Ser 
            100                 105                 110         


Ser Ser Arg Asp Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             


Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
            180                 185                 190         


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300             


<210>  457
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  457

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  458
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  458

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  459
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  459

Cys Ala Val Asn Asp Ala Gly Asn Met Leu Thr Phe 
1               5                   10          


<210>  460
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  460

Asp Phe Gln Ala Thr Thr 
1               5       


<210>  461
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  461

Ser Asn Glu Gly Ser Lys Ala 
1               5           


<210>  462
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  462

Cys Ser Ala Ala Gly Gln Ala Asn Thr Glu Ala Phe Phe 
1               5                   10              


<210>  463
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  463

Met His Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Asp Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met 
        115                 120                 125             


Val Lys Pro 
    130     


<210>  464
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  464

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ala Gly Gln Ala Asn Thr Glu 
        115                 120                 125             


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
    130                 135                 140 


<210>  465
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  465

Met His Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Asp Ala Gly Asn Met Leu Thr Phe Gly Gly Gly Thr Arg Leu Met 
        115                 120                 125             


Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  466
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  466

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ala Gly Gln Ala Asn Thr Glu 
        115                 120                 125             


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser 
305                 310             


<210>  467
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  467

Asp Ser Ala Ser Asn Tyr 
1               5       


<210>  468
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  468

Ile Arg Ser Asn Val Gly Glu 
1               5           


<210>  469
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  469

Cys Ala Ala Ser Lys Ser Ala Ile Met Val Val Leu Gln Thr Ser Ser 
1               5                   10                  15      


Ser Leu 
        


<210>  470
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  470

Met Asn His Glu Tyr 
1               5   


<210>  471
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  471

Ser Met Asn Val Glu Val 
1               5       


<210>  472
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  472

Cys Ala Ser Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe 
1               5                   10                  


<210>  473
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  473

Met Ala Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Lys Ser Ala Ile Met Val Val Leu Gln Thr Ser Ser Ser Leu Glu Leu 
        115                 120                 125             


Ala Leu Cys Leu Leu Ser Ser Gln Val 
    130                 135         


<210>  474
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  474

Met His Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu 
    130         


<210>  475
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  475

Met Ala Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Lys Ser Ala Ile Met Val Val Leu Gln Thr Ser Ser Ser Leu Glu Leu 
        115                 120                 125             


Ala Leu Cys Leu Leu Ser Ser Gln Val Asn Ile Gln Asn Pro Glu Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu 
                165                 170                 175     


Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met 
            180                 185                 190         


Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe 
        195                 200                 205             


Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser 
    210                 215                 220                 


Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  476
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  476

Met His Pro Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Gly Pro Leu Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr 
            20                  25                  30          


Val Thr Gly Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln 
    50                  55                  60                  


Ile Tyr Tyr Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro 
65                  70                  75                  80  


Glu Gly Tyr Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile 
                85                  90                  95      


Leu Glu Ser Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Ile Gln Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  477
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  477

Asp Arg Gly Ser Gln Ser 
1               5       


<210>  478
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  478

Ile Tyr Ser Asn Gly Asp 
1               5       


<210>  479
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  479

Cys Ala Trp Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
1               5                   10                  


<210>  480
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  480

Met Asn His Glu Tyr 
1               5   


<210>  481
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  481

Ser Val Gly Glu Gly Thr 
1               5       


<210>  482
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  482

Cys Ala Ser Ser Tyr Ser Gln Ala Trp Gly Gln Pro Gln His Phe 
1               5                   10                  15  


<210>  483
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  483

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Trp 
            100                 105                 110         


Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu 
        115                 120                 125             


Leu Thr Val Asn Pro 
    130             


<210>  484
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  484

Met His Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ser Gln Ala Trp Gly Gln Pro Gln His Phe Gly Asp Gly Thr 
        115                 120                 125             


Arg Leu Ser Ile Leu 
    130             


<210>  485
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  485

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Trp 
            100                 105                 110         


Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu 
        115                 120                 125             


Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 


<210>  486
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  486

Met His Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Ser Gln Ala Trp Gly Gln Pro Gln His Phe Gly Asp Gly Thr 
        115                 120                 125             


Arg Leu Ser Ile Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  487
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  487

Ser Ser Asn Phe Tyr Ala 
1               5       


<210>  488
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  488

Met Thr Leu Asn Gly Asp Glu 
1               5           


<210>  489
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  489

Cys Ala Leu Ile Thr Gly Gly Gly Asn Lys Leu Thr Phe 
1               5                   10              


<210>  490
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  490

Met Asn His Glu Tyr 
1               5   


<210>  491
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  491

Ser Val Gly Glu Gly Thr 
1               5       


<210>  492
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  492

Cys Ala Ser Arg Leu Gln Gly Trp Asn Ser Pro Leu His Phe 
1               5                   10                  


<210>  493
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  493

Met Ala Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Ile Thr Gly Gly Gly Asn Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Gln Leu Lys Val Glu Leu 
    130                 


<210>  494
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  494

Met His Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Arg Leu Gln Gly Trp Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr 
    130         


<210>  495
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  495

Met Ala Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Ile Thr Gly Gly Gly Asn Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Gln Leu Lys Val Glu Leu Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270     


<210>  496
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  496

Met His Leu Gly Leu Leu Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Arg Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Leu Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Glu Gly Thr Thr Ala Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asp Gly Tyr Asn Val Ser Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Arg Leu Gln Gly Trp Asn Ser Pro Leu His Phe Gly Asn Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser 
305 


<210>  497
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  497

His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn 
1               5                   10                  15  


<210>  498
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  498

Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg 
1               5                   10                  15  


<210>  499
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  499

Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg Arg 
1               5                   10                  15  


<210>  500
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  500

Tyr Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg Arg Pro 
1               5                   10                  15  


<210>  501
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  501

Met Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg Arg Pro Ile 
1               5                   10                  15  


<210>  502
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  502

Cys Asn Ser Ser Cys Met Gly Ser Met Asn Arg Arg Pro Ile Leu 
1               5                   10                  15  


<210>  503
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  503

Asn Ser Ser Cys Met Gly Ser Met Asn Arg Arg Pro Ile Leu Thr 
1               5                   10                  15  


<210>  504
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  504

Ser Ser Cys Met Gly Ser Met Asn Arg Arg Pro Ile Leu Thr Ile 
1               5                   10                  15  


<210>  505
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  505

Ser Cys Met Gly Ser Met Asn Arg Arg Pro Ile Leu Thr Ile Ile 
1               5                   10                  15  


<210>  506
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  506

Cys Met Gly Ser Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
1               5                   10                  15  


<210>  507
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  507

Met Gly Ser Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu 
1               5                   10                  15  


<210>  508
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  508

Asp Arg Asn Thr Phe Arg His Ser Val Val Val Pro Cys Glu Pro 
1               5                   10                  15  


<210>  509
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  509

Arg Asn Thr Phe Arg His Ser Val Val Val Pro Cys Glu Pro Pro 
1               5                   10                  15  


<210>  510
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  510

Asn Thr Phe Arg His Ser Val Val Val Pro Cys Glu Pro Pro Glu 
1               5                   10                  15  


<210>  511
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  511

Thr Phe Arg His Ser Val Val Val Pro Cys Glu Pro Pro Glu Val 
1               5                   10                  15  


<210>  512
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  512

Phe Arg His Ser Val Val Val Pro Cys Glu Pro Pro Glu Val Gly 
1               5                   10                  15  


<210>  513
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  513

Arg His Ser Val Val Val Pro Cys Glu Pro Pro Glu Val Gly Ser 
1               5                   10                  15  


<210>  514
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  514

His Ser Val Val Val Pro Cys Glu Pro Pro Glu Val Gly Ser Asp 
1               5                   10                  15  


<210>  515
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  515

Ser Val Val Val Pro Cys Glu Pro Pro Glu Val Gly Ser Asp Cys 
1               5                   10                  15  


<210>  516
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  516

Val Val Val Pro Cys Glu Pro Pro Glu Val Gly Ser Asp Cys Thr 
1               5                   10                  15  


<210>  517
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  517

Val Val Pro Cys Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
1               5                   10                  15  


<210>  518
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  518

Val Pro Cys Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr Ile 
1               5                   10                  15  


<210>  519
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  519

Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro 
1               5                   10                  15  


<210>  520
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  520

Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His 
1               5                   10                  15  


<210>  521
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  521

Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His His 
1               5                   10                  15  


<210>  522
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  522

Ser Gln His Met Thr Glu Val Val Arg His Cys Pro His His Glu 
1               5                   10                  15  


<210>  523
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  523

Gln His Met Thr Glu Val Val Arg His Cys Pro His His Glu Arg 
1               5                   10                  15  


<210>  524
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  524

His Met Thr Glu Val Val Arg His Cys Pro His His Glu Arg Cys 
1               5                   10                  15  


<210>  525
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  525

Met Thr Glu Val Val Arg His Cys Pro His His Glu Arg Cys Ser 
1               5                   10                  15  


<210>  526
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  526

Thr Glu Val Val Arg His Cys Pro His His Glu Arg Cys Ser Asp 
1               5                   10                  15  


<210>  527
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  527

Glu Val Val Arg His Cys Pro His His Glu Arg Cys Ser Asp Ser 
1               5                   10                  15  


<210>  528
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  528

Val Val Arg His Cys Pro His His Glu Arg Cys Ser Asp Ser Asp 
1               5                   10                  15  


<210>  529
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  529

Val Arg His Cys Pro His His Glu Arg Cys Ser Asp Ser Asp Gly 
1               5                   10                  15  


<210>  530
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  530

His Met Thr Glu Val Val Arg His Cys 
1               5                   


<210>  531
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  531

Ser Gln His Met Thr Glu Val Val Arg His 
1               5                   10  


<210>  532
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  532

His Met Thr Glu Val Val Arg Arg Cys 
1               5                   


<210>  533
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  533

Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu 
1               5                   10              


<210>  534
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  534

Arg Asn Thr Phe Arg His Ser Val Val Val Pro Cys Glu 
1               5                   10              


<210>  535
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  535

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe 
                325                 330                 335     


Gln Lys Glu Asn Cys 
            340     


<210>  536
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  536

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu 
                325                 330                 335     


Arg Trp Cys Tyr Phe Leu Ile Asn Ser Ser 
            340                 345     


<210>  537
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  537

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
    290                 295                 300                 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
305                 310                 315                 320 


Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys Lys Gly Gln 
                325                 330                 335     


Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu Gly Pro Asp 
            340                 345                 350         


Ser Asp 
        


<210>  538
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  538

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn Cys 
    290                 295                 300         


<210>  539
<211>  307
<212>  PRT
<213>  Homo sapiens

<400>  539

Met Asp Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr 
1               5                   10                  15      


Glu Asp Pro Gly Pro Asp Glu Ala Pro Arg Met Pro Glu Ala Ala Pro 
            20                  25                  30          


Pro Val Ala Pro Ala Pro Ala Ala Pro Thr Pro Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Pro Ser Trp Pro Leu Ser Ser Ser Val Pro Ser Gln Lys Thr Tyr 
    50                  55                  60                  


Gln Gly Ser Tyr Gly Phe Arg Leu Gly Phe Leu His Ser Gly Thr Ala 
65                  70                  75                  80  


Lys Ser Val Thr Cys Thr Tyr Ser Pro Ala Leu Asn Lys Met Phe Cys 
                85                  90                  95      


Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp Ser Thr Pro 
            100                 105                 110         


Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys Gln Ser Gln 
        115                 120                 125             


His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu Arg Cys Ser 
    130                 135                 140                 


Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg Val Glu Gly 
145                 150                 155                 160 


Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe Arg His Ser 
                165                 170                 175     


Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp Cys Thr Thr 
            180                 185                 190         


Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn 
        195                 200                 205             


Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser Ser Gly Asn 
    210                 215                 220                 


Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala Cys Pro Gly 
225                 230                 235                 240 


Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys Gly Glu Pro 
                245                 250                 255     


His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu Pro Asn Asn 
            260                 265                 270         


Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Glu Tyr 
        275                 280                 285             


Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr Phe Leu Ile 
    290                 295                 300                 


Asn Ser Ser 
305         


<210>  540
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  540

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met 
        195                 200                 205             


Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly 
    210                 215                 220                 


Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His Leu Lys Ser Lys 
225                 230                 235                 240 


Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met Phe Lys Thr Glu 
                245                 250                 255     


Gly Pro Asp Ser Asp 
            260     


<210>  541
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  541

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Asp Gln Thr Ser Phe Gln Lys Glu Asn 
        195                 200                 205             


Cys 
    


<210>  542
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  542

Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln Leu Trp Val Asp 
1               5                   10                  15      


Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met Ala Ile Tyr Lys 
            20                  25                  30          


Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys Pro His His Glu 
        35                  40                  45              


Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln His Leu Ile Arg 
    50                  55                  60                  


Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp Arg Asn Thr Phe 
65                  70                  75                  80  


Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu Val Gly Ser Asp 
                85                  90                  95      


Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
            100                 105                 110         


Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
        115                 120                 125             


Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val Arg Val Cys Ala 
    130                 135                 140                 


Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn Leu Arg Lys Lys 
145                 150                 155                 160 


Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr Lys Arg Ala Leu 
                165                 170                 175     


Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys Lys Pro Leu Asp 
            180                 185                 190         


Gly Glu Tyr Phe Thr Leu Gln Met Leu Leu Asp Leu Arg Trp Cys Tyr 
        195                 200                 205             


Phe Leu Ile Asn Ser Ser 
    210                 


<210>  543
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  543

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Val Asn Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
305                 310                 315                 320 


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Leu Leu Leu 
                325                 330                 335     


Ile Pro Val Leu Gly Met Ile Phe Ala Leu Arg Asp Ala Arg Ala Gln 
            340                 345                 350         


Ser Val Ser Gln His Asn His His Val Ile Leu Ser Glu Ala Ala Ser 
        355                 360                 365             


Leu Glu Leu Gly Cys Asn Tyr Ser Tyr Gly Gly Thr Val Asn Leu Phe 
    370                 375                 380                 


Trp Tyr Val Gln Tyr Pro Gly Gln His Leu Gln Leu Leu Leu Lys Tyr 
385                 390                 395                 400 


Phe Ser Gly Asp Pro Leu Val Lys Gly Ile Lys Gly Phe Glu Ala Glu 
                405                 410                 415     


Phe Ile Lys Ser Lys Phe Ser Phe Asn Leu Arg Lys Pro Ser Val Gln 
            420                 425                 430         


Trp Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val Lys Gly Asp Tyr Lys 
        435                 440                 445             


Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  544
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  544

Met Ala Pro Gly Leu Leu His Trp Met Ala Leu Cys Leu Leu Gly Thr 
1               5                   10                  15      


Gly His Gly Asp Ala Met Val Ile Gln Asn Pro Arg Tyr Gln Val Thr 
            20                  25                  30          


Gln Phe Gly Lys Pro Val Thr Leu Ser Cys Ser Gln Thr Leu Asn His 
        35                  40                  45              


Asn Val Met Tyr Trp Tyr Gln Gln Lys Ser Ser Gln Ala Pro Lys Leu 
    50                  55                  60                  


Leu Phe His Tyr Tyr Asp Lys Asp Phe Asn Asn Glu Ala Asp Thr Pro 
65                  70                  75                  80  


Asp Asn Phe Gln Ser Arg Arg Pro Asn Thr Ser Phe Cys Phe Leu Asp 
                85                  90                  95      


Ile Arg Ser Pro Gly Leu Gly Asp Ala Ala Met Tyr Leu Cys Ala Thr 
            100                 105                 110         


Ser Arg Glu Leu Arg Gly Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
305                 310                 315                 320 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Thr Ala 
                325                 330                 335     


Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val Val Ser Ser Met 
            340                 345                 350         


Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser Val Val Glu Lys 
        355                 360                 365             


Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg Asp Thr Thr Tyr 
    370                 375                 380                 


Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu Leu Val Phe Leu 
385                 390                 395                 400 


Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile Ser Gly Arg Tyr 
                405                 410                 415     


Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn Phe Thr Ile Thr 
            420                 425                 430         


Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser Glu 
        435                 440                 445             


Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu Thr 
    450                 455                 460                 


Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
465                 470                 475                 480 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
                485                 490                 495     


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
            500                 505                 510         


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
        515                 520                 525             


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
    530                 535                 540                 


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
545                 550                 555                 560 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
                565                 570                 575     


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
            580                 585                 590         


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 


<210>  545
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  545

Met Ala Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu 
1               5                   10                  15      


Trp Ala Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln 
            20                  25                  30          


Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met 
        35                  40                  45              


Asn His Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu 
    50                  55                  60                  


Arg Leu Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu 
65                  70                  75                  80  


Val Pro Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro 
                85                  90                  95      


Leu Arg Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys 
            100                 105                 110         


Ala Ser Ser Tyr Arg Glu Ser His Tyr Gly Tyr Thr Phe Gly Ser Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Trp 
                325                 330                 335     


Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr Thr Gly 
            340                 345                 350         


Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly Ala Ile 
        355                 360                 365             


Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly Leu Phe 
    370                 375                 380                 


Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser Tyr Asn 
385                 390                 395                 400 


Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe Leu Ser 
                405                 410                 415     


Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln Met Lys 
            420                 425                 430         


Asp Ser Ala Ser Tyr Leu Cys Ala Val Lys Trp Thr Gly Gly Phe Lys 
        435                 440                 445             


Thr Ile Phe Gly Ala Gly Thr Arg Leu Phe Val Lys Ala Asn Ile Gln 
    450                 455                 460                 


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
465                 470                 475                 480 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
                485                 490                 495     


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
            500                 505                 510         


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
        515                 520                 525             


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
    530                 535                 540                 


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
545                 550                 555                 560 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
                565                 570                 575     


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
            580                 585                 590         


Leu Arg Leu Trp Ser Ser 
        595             


<210>  546
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  546

Met Ala Leu Leu Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu 
1               5                   10                  15      


Pro Gly Ser Leu Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
            20                  25                  30          


Pro Ser Trp Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
        35                  40                  45              


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
    50                  55                  60                  


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
65                  70                  75                  80  


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
                85                  90                  95      


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
            100                 105                 110         


Asp Ser Ser Phe Tyr Ile Cys Ser Ala Ala Gly Gln Ala Asn Thr Glu 
        115                 120                 125             


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Arg Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser 
305                 310                 315                 320 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
                325                 330                 335     


Asn Pro Gly Pro Met His Ser Leu Arg Val Leu Leu Val Ile Leu Trp 
            340                 345                 350         


Leu Gln Leu Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn 
        355                 360                 365             


Ser Gly Pro Leu Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys 
    370                 375                 380                 


Thr Tyr Ser Asp Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr 
385                 390                 395                 400 


Ser Gly Lys Ser Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp 
                405                 410                 415     


Lys Glu Asp Gly Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr 
            420                 425                 430         


Val Ser Leu Leu Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr 
        435                 440                 445             


Leu Cys Ala Val Asn Asp Ala Gly Asn Met Leu Thr Phe Gly Gly Gly 
    450                 455                 460                 


Thr Arg Leu Met Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
465                 470                 475                 480 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
                485                 490                 495     


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
            500                 505                 510         


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
        515                 520                 525             


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
    530                 535                 540                 


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
545                 550                 555                 560 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
                565                 570                 575     


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
            580                 585                 590         


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605             


<210>  547
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  547

Met Ala Ile Gly Leu Leu Cys Cys Val Ala Phe Ser Leu Leu Trp Ala 
1               5                   10                  15      


Ser Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr Asp Lys Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys Arg Glu Phe Ser Leu Arg 
                85                  90                  95      


Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Glu Gly Leu Trp Gln Val Gly Asp Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             


Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile 
                325                 330                 335     


Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser Trp Val 
            340                 345                 350         


Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val 
        355                 360                 365             


Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala 
    370                 375                 380                 


Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys 
385                 390                 395                 400 


Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr 
                405                 410                 415     


Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp 
            420                 425                 430         


Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Gln Pro Gly 
        435                 440                 445             


Gly Tyr Gln Lys Val Thr Phe Gly Thr Gly Thr Lys Leu Gln Val Ile 
    450                 455                 460                 


Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  548
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  548

Met Ala Thr Arg Leu Phe Phe Tyr Val Ala Leu Cys Leu Leu Trp Thr 
1               5                   10                  15      


Gly His Met Asp Ala Gly Ile Thr Gln Ser Pro Arg His Lys Val Thr 
            20                  25                  30          


Glu Thr Gly Thr Pro Val Thr Leu Arg Cys His Gln Thr Glu Asn His 
        35                  40                  45              


Arg Tyr Met Tyr Trp Tyr Arg Gln Asp Pro Gly His Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Tyr Gly Val Lys Asp Thr Asp Lys Gly Glu Val Ser 
65                  70                  75                  80  


Asp Gly Tyr Ser Val Ser Arg Ser Lys Thr Glu Asp Phe Leu Leu Thr 
                85                  90                  95      


Leu Glu Ser Ala Thr Ser Ser Gln Thr Ser Val Tyr Phe Cys Ala Ile 
            100                 105                 110         


Ser Glu Leu Val Thr Gly Asp Ser Pro Leu His Phe Gly Asn Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
    290                 295                 300                 


Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
305                 310                 315                 320 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Thr Arg 
                325                 330                 335     


Val Ser Leu Leu Trp Ala Val Val Val Ser Thr Cys Leu Glu Ser Gly 
            340                 345                 350         


Met Ala Gln Thr Val Thr Gln Ser Gln Pro Glu Met Ser Val Gln Glu 
        355                 360                 365             


Ala Glu Thr Val Thr Leu Ser Cys Thr Tyr Asp Thr Ser Glu Asn Asn 
    370                 375                 380                 


Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Arg Gln Met Ile Leu 
385                 390                 395                 400 


Val Ile Arg Gln Glu Ala Tyr Lys Gln Gln Asn Ala Thr Glu Asn Arg 
                405                 410                 415     


Phe Ser Val Asn Phe Gln Lys Ala Ala Lys Ser Phe Ser Leu Lys Ile 
            420                 425                 430         


Ser Asp Ser Gln Leu Gly Asp Thr Ala Met Tyr Phe Cys Ala Phe Met 
        435                 440                 445             


Gly Tyr Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
    450                 455                 460                 


Lys Leu Ser Val Ile Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr 
465                 470                 475                 480 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
                485                 490                 495     


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
            500                 505                 510         


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
        515                 520                 525             


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
    530                 535                 540                 


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
545                 550                 555                 560 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
                565                 570                 575     


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
            580                 585                 590         


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605         


<210>  549
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  549

Met Ala Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile 
            20                  25                  30          


Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His 
        35                  40                  45              


Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu 
    50                  55                  60                  


Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro 
65                  70                  75                  80  


Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Asp Pro Gly Asp Thr Gly Glu Leu Phe Phe Gly Glu Gly 
        115                 120                 125             


Ser Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
            180                 185                 190         


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
            260                 265                 270         


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
    290                 295                 300                 


Lys Asn Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
305                 310                 315                 320 


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Glu 
                325                 330                 335     


Ser Phe Leu Gly Gly Val Leu Leu Ile Leu Trp Leu Gln Val Asp Trp 
            340                 345                 350         


Val Lys Ser Gln Lys Ile Glu Gln Asn Ser Glu Ala Leu Asn Ile Gln 
        355                 360                 365             


Glu Gly Lys Thr Ala Thr Leu Thr Cys Asn Tyr Thr Asn Tyr Ser Pro 
    370                 375                 380                 


Ala Tyr Leu Gln Trp Tyr Arg Gln Asp Pro Gly Arg Gly Pro Val Phe 
385                 390                 395                 400 


Leu Leu Leu Ile Arg Glu Asn Glu Lys Glu Lys Arg Lys Glu Arg Leu 
                405                 410                 415     


Lys Val Thr Phe Asp Thr Thr Leu Lys Gln Ser Leu Phe His Ile Thr 
            420                 425                 430         


Ala Ser Gln Pro Ala Asp Ser Ala Thr Tyr Leu Cys Ala Leu Asp Ile 
        435                 440                 445             


Tyr Pro His Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val Lys 
    450                 455                 460                 


Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


<210>  550
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  550

Met Ala Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Phe Arg 
    290                 295                 300                 


Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala Gly Pro Val Asp 
305                 310                 315                 320 


Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly Gln 
                325                 330                 335     


Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val Tyr 
            340                 345                 350         


Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile Gln Tyr 
        355                 360                 365             


Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe Ser 
    370                 375                 380                 


Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Val Gly Ser 
                405                 410                 415     


Ser Ser Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            420                 425                 430         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        435                 440                 445             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    450                 455                 460                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
465                 470                 475                 480 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
                485                 490                 495     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            500                 505                 510         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        515                 520                 525             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    530                 535                 540                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
545                 550                 555                 560 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                565                 570                 575     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            580                 585                 590         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605         


<210>  551
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  551

Met Ala Thr Ala Ser Leu Leu Arg Ala Val Ile Ala Ser Ile Cys Val 
1               5                   10                  15      


Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser 
            20                  25                  30          


Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg 
        35                  40                  45              


Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu 
    50                  55                  60                  


Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile 
65                  70                  75                  80  


Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn 
                85                  90                  95      


Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys 
            100                 105                 110         


Ala Leu Ser Glu Val Asp Ser Gly Asn Thr Pro Leu Val Phe Gly Lys 
        115                 120                 125             


Gly Thr Arg Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Phe Arg 
    290                 295                 300                 


Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly Ala Gly Pro Val Asp 
305                 310                 315                 320 


Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile Thr Ala Thr Gly Gln 
                325                 330                 335     


Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly Asp Leu Ser Val Tyr 
            340                 345                 350         


Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln Phe Leu Ile His Tyr 
        355                 360                 365             


Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile Leu Glu Arg Phe Ser 
    370                 375                 380                 


Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu Asn Leu Ser Ser Leu 
385                 390                 395                 400 


Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala Ser Ser Val Gly Ser 
                405                 410                 415     


Ser Ser Ser Thr Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            420                 425                 430         


Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
        435                 440                 445             


Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
    450                 455                 460                 


Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
465                 470                 475                 480 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala 
                485                 490                 495     


Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            500                 505                 510         


Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        515                 520                 525             


Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
    530                 535                 540                 


Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
545                 550                 555                 560 


Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                565                 570                 575     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            580                 585                 590         


Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605         


<210>  552
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  552

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Leu Leu Leu 
    290                 295                 300                 


Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu Pro Gly Ser Leu Ala Gly 
305                 310                 315                 320 


Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val Ile Cys 
                325                 330                 335     


Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp Phe Gln 
            340                 345                 350         


Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser Leu Met 
        355                 360                 365             


Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu Gln Gly 
    370                 375                 380                 


Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr Leu Ser 
385                 390                 395                 400 


Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe Tyr Ile 
                405                 410                 415     


Cys Ser Gly Gly Leu Glu Glu Ala Ala Arg Gln Phe Ile Gly Pro Gly 
            420                 425                 430         


Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
        435                 440                 445             


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
    450                 455                 460                 


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
465                 470                 475                 480 


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
                485                 490                 495     


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
            500                 505                 510         


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
        515                 520                 525             


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
    530                 535                 540                 


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
545                 550                 555                 560 


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
                565                 570                 575     


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
            580                 585                 590         


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
        595                 600                 605             


Lys Asn Ser 
    610     


<210>  553
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  553

Met Ala Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  


Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  


Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      


Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Met Thr Ser Pro Tyr Asn Asn Asn Asp Met Arg Phe Gly Ala Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Leu Leu Leu 
    290                 295                 300                 


Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His 
305                 310                 315                 320 


Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys 
                325                 330                 335     


Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe 
            340                 345                 350         


Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys 
        355                 360                 365             


Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His 
    370                 375                 380                 


Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu 
385                 390                 395                 400 


Asp Ser Ser Phe Tyr Ile Cys Ser Gly Gly Leu Glu Glu Ala Ala Arg 
                405                 410                 415     


Gln Phe Ile Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg 
            420                 425                 430         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        435                 440                 445             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                485                 490                 495     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            500                 505                 510         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        515                 520                 525             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    530                 535                 540                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
545                 550                 555                 560 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                565                 570                 575     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            580                 585                 590         


Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600     


<210>  554
<211>  596
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  554

Met Ala Leu Val Ala Arg Val Thr Val Phe Leu Thr Phe Gly Thr Ile 
1               5                   10                  15      


Ile Asp Ala Lys Thr Thr Gln Pro Pro Ser Met Asp Cys Ala Glu Gly 
            20                  25                  30          


Arg Ala Ala Asn Leu Pro Cys Asn His Ser Thr Ile Ser Gly Asn Glu 
        35                  40                  45              


Tyr Val Tyr Trp Tyr Arg Gln Ile His Ser Gln Gly Pro Gln Tyr Ile 
    50                  55                  60                  


Ile His Gly Leu Lys Asn Asn Glu Thr Asn Glu Met Ala Ser Leu Ile 
65                  70                  75                  80  


Ile Thr Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu Pro His Ala Thr 
                85                  90                  95      


Leu Arg Asp Thr Ala Val Tyr Tyr Cys Ile Val Pro Asn Asp Tyr Lys 
            100                 105                 110         


Leu Ser Phe Gly Ala Gly Thr Thr Val Thr Val Arg Ala Asn Ile Gln 
        115                 120                 125             


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
    130                 135                 140                 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
145                 150                 155                 160 


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
                165                 170                 175     


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
            180                 185                 190         


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
        195                 200                 205             


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
    210                 215                 220                 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
225                 230                 235                 240 


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
                245                 250                 255     


Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr 
            260                 265                 270         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        275                 280                 285             


Pro Met His Ile Arg Leu Leu Cys Arg Val Ala Phe Cys Phe Leu Ala 
    290                 295                 300                 


Val Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser Arg Tyr Leu Val 
305                 310                 315                 320 


Lys Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val Gln Asp Met Asp 
                325                 330                 335     


His Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg 
            340                 345                 350         


Leu Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu Lys Gly Asp Ile 
        355                 360                 365             


Pro Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu Arg Phe Ser Leu 
    370                 375                 380                 


Ile Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met Tyr Leu Cys Ala 
385                 390                 395                 400 


Ser Ser Phe Gly Thr Gly Ser Ile Gln Glu Thr Gln Tyr Phe Gly Pro 
                405                 410                 415     


Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
            420                 425                 430         


Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
        435                 440                 445             


Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
    450                 455                 460                 


Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys 
465                 470                 475                 480 


Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
                485                 490                 495     


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
            500                 505                 510         


Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
        515                 520                 525             


Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
    530                 535                 540                 


Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly 
545                 550                 555                 560 


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
                565                 570                 575     


Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys 
            580                 585                 590         


Arg Lys Asn Ser 
        595     


<210>  555
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  555

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Asn 
            100                 105                 110         


Pro Asn Ala Gly Gly Thr Ser Tyr Gly Lys Leu Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Ile Leu Thr Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
        275                 280                 285             


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Pro Arg Leu 
    290                 295                 300                 


Leu Phe Trp Ala Leu Leu Cys Leu Leu Gly Thr Gly Pro Val Glu Ala 
305                 310                 315                 320 


Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln 
                325                 330                 335     


Ala Thr Leu Arg Cys Ser Pro Ile Ser Gly His Thr Ser Val Tyr Trp 
            340                 345                 350         


Tyr Gln Gln Ala Leu Gly Leu Gly Leu Gln Phe Leu Leu Trp Tyr Asp 
        355                 360                 365             


Glu Gly Glu Glu Arg Asn Arg Gly Asn Phe Pro Pro Arg Phe Ser Gly 
    370                 375                 380                 


Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Glu 
385                 390                 395                 400 


Leu Glu Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Ser Pro Gly Ala 
                405                 410                 415     


Thr Ser Gly Gly Ala Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser 
            420                 425                 430         


Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
        435                 440                 445             


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
    450                 455                 460                 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
465                 470                 475                 480 


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
                485                 490                 495     


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
            500                 505                 510         


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
        515                 520                 525             


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
    530                 535                 540                 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
545                 550                 555                 560 


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu 
                565                 570                 575     


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
            580                 585                 590         


Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys 
        595                 600                 605             


Asn Ser 
    610 


<210>  556
<211>  614
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  556

Met Ala Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Leu 
    290                 295                 300                 


Leu Leu Leu Leu Gly Pro Gly Ile Ser Leu Leu Leu Pro Gly Ser Leu 
305                 310                 315                 320 


Ala Gly Ser Gly Leu Gly Ala Val Val Ser Gln His Pro Ser Trp Val 
                325                 330                 335     


Ile Cys Lys Ser Gly Thr Ser Val Lys Ile Glu Cys Arg Ser Leu Asp 
            340                 345                 350         


Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg Gln Phe Pro Lys Gln Ser 
        355                 360                 365             


Leu Met Leu Met Ala Thr Ser Asn Glu Gly Ser Lys Ala Thr Tyr Glu 
    370                 375                 380                 


Gln Gly Val Glu Lys Asp Lys Phe Leu Ile Asn His Ala Ser Leu Thr 
385                 390                 395                 400 


Leu Ser Thr Leu Thr Val Thr Ser Ala His Pro Glu Asp Ser Ser Phe 
                405                 410                 415     


Tyr Ile Cys Ser Ala Arg Asp Leu Gln Arg Ser Tyr Glu Gln Tyr Phe 
            420                 425                 430         


Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr 
        435                 440                 445             


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
    450                 455                 460                 


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
465                 470                 475                 480 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
                485                 490                 495     


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
            500                 505                 510         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
        515                 520                 525             


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
    530                 535                 540                 


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
545                 550                 555                 560 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
                565                 570                 575     


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
            580                 585                 590         


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
        595                 600                 605             


Val Lys Arg Lys Asn Ser 
    610                 


<210>  557
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  557

Met Ala Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      


Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          


Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              


Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  


Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  


Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      


Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         


Ile Pro Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys 
        115                 120                 125             


Gly Thr His Leu Ile Ile Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Leu 
    290                 295                 300                 


Leu Leu Leu Leu Gly Pro Ala Gly Ser Gly Leu Gly Ala Val Val Ser 
305                 310                 315                 320 


Gln His Pro Ser Arg Val Ile Cys Lys Ser Gly Thr Ser Val Lys Ile 
                325                 330                 335     


Glu Cys Arg Ser Leu Asp Phe Gln Ala Thr Thr Met Phe Trp Tyr Arg 
            340                 345                 350         


Gln Phe Pro Lys Gln Ser Leu Met Leu Met Ala Thr Ser Asn Glu Gly 
        355                 360                 365             


Ser Lys Ala Thr Tyr Glu Gln Gly Val Glu Lys Asp Lys Phe Leu Ile 
    370                 375                 380                 


Asn His Ala Ser Leu Thr Leu Ser Thr Leu Thr Val Thr Ser Ala His 
385                 390                 395                 400 


Pro Glu Asp Ser Ser Phe Tyr Ile Cys Ser Ala Arg Asp Leu Gln Arg 
                405                 410                 415     


Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu 
            420                 425                 430         


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
        435                 440                 445             


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
    450                 455                 460                 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
465                 470                 475                 480 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
                485                 490                 495     


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            500                 505                 510         


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
        515                 520                 525             


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
    530                 535                 540                 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
545                 550                 555                 560 


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                565                 570                 575     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
            580                 585                 590         


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 


<210>  558
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  558

Met Ala Gly Ile Arg Ala Leu Phe Met Tyr Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Trp Val Ser Arg Gly Glu Ser Val Gly Leu His Leu Pro Thr Leu Ser 
            20                  25                  30          


Val Gln Glu Gly Asp Asn Ser Ile Ile Asn Cys Ala Tyr Ser Asn Ser 
        35                  40                  45              


Ala Ser Asp Tyr Phe Ile Trp Tyr Lys Gln Glu Ser Gly Lys Gly Pro 
    50                  55                  60                  


Gln Phe Ile Ile Asp Ile Arg Ser Asn Met Asp Lys Arg Gln Gly Gln 
65                  70                  75                  80  


Arg Val Thr Val Leu Leu Asn Lys Thr Val Lys His Leu Ser Leu Gln 
                85                  90                  95      


Ile Ala Ala Thr Gln Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala Glu 
            100                 105                 110         


Pro Val Gly Gly Leu Asn Ser Gly Tyr Ala Leu Asn Phe Gly Lys Gly 
        115                 120                 125             


Thr Ser Leu Leu Val Thr Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
        275                 280                 285             


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Pro Gly Leu 
    290                 295                 300                 


Leu Cys Trp Val Leu Leu Cys Leu Leu Gly Ala Gly Pro Val Asp Ala 
305                 310                 315                 320 


Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln 
                325                 330                 335     


Val Thr Leu Arg Cys Ser Pro Ile Ser Gly His Lys Ser Val Ser Trp 
            340                 345                 350         


Tyr Gln Gln Val Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr 
        355                 360                 365             


Glu Lys Glu Glu Arg Gly Arg Gly Asn Phe Pro Asp Arg Phe Ser Ala 
    370                 375                 380                 


Arg Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Leu 
385                 390                 395                 400 


Leu Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Gly Gly Arg Thr 
                405                 410                 415     


Ser Gly Ala Tyr Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            420                 425                 430         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        435                 440                 445             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    450                 455                 460                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
465                 470                 475                 480 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
                485                 490                 495     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            500                 505                 510         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        515                 520                 525             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    530                 535                 540                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
545                 550                 555                 560 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                565                 570                 575     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            580                 585                 590         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605     


<210>  559
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  559

Met Ala Lys Met Leu Glu Cys Ala Phe Ile Val Leu Trp Leu Gln Leu 
1               5                   10                  15      


Gly Trp Leu Ser Gly Glu Asp Gln Val Thr Gln Ser Pro Glu Ala Leu 
            20                  25                  30          


Arg Leu Gln Glu Gly Glu Ser Ser Ser Leu Asn Cys Ser Tyr Thr Val 
        35                  40                  45              


Ser Gly Leu Arg Gly Leu Phe Trp Tyr Arg Gln Asp Pro Gly Lys Gly 
    50                  55                  60                  


Pro Glu Phe Leu Phe Thr Leu Tyr Ser Ala Gly Glu Glu Lys Glu Lys 
65                  70                  75                  80  


Glu Arg Leu Lys Ala Thr Leu Thr Lys Lys Glu Ser Phe Leu His Ile 
                85                  90                  95      


Thr Ala Pro Lys Pro Glu Asp Ser Ala Thr Tyr Leu Cys Ala Val Thr 
            100                 105                 110         


Ala His Arg Gly Ser Thr Leu Gly Arg Leu Tyr Phe Gly Arg Gly Thr 
        115                 120                 125             


Gln Leu Thr Val Trp Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Pro Gly Leu Leu 
    290                 295                 300                 


Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala Gly Leu Val Asp Ala Gly 
305                 310                 315                 320 


Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln Val 
                325                 330                 335     


Thr Leu Arg Cys Ser Pro Lys Ser Gly His Asp Thr Val Ser Trp Tyr 
            340                 345                 350         


Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr Glu 
        355                 360                 365             


Glu Glu Glu Arg Gln Arg Gly Asn Phe Pro Asp Arg Phe Ser Gly His 
    370                 375                 380                 


Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Leu Leu 
385                 390                 395                 400 


Gly Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Arg Arg Gly Gly Ala 
                405                 410                 415     


Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu 
            420                 425                 430         


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
        435                 440                 445             


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
    450                 455                 460                 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
465                 470                 475                 480 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
                485                 490                 495     


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            500                 505                 510         


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
        515                 520                 525             


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
    530                 535                 540                 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
545                 550                 555                 560 


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                565                 570                 575     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
            580                 585                 590         


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 


<210>  560
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  560

Met Ala Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Ser Val Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


His Leu Ile Ile Gln Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu 
    290                 295                 300                 


Phe Trp Val Ala Phe Cys Leu Leu Gly Ala Asp His Thr Gly Ala Gly 
305                 310                 315                 320 


Val Ser Gln Ser Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp Val 
                325                 330                 335     


Glu Leu Arg Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp Tyr 
            340                 345                 350         


Arg Gln Ser Leu Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln Gly 
        355                 360                 365             


Asn Ser Ala Pro Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser Ala 
    370                 375                 380                 


Glu Arg Thr Gly Gly Ser Val Ser Thr Leu Thr Ile Gln Arg Thr Gln 
385                 390                 395                 400 


Gln Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Thr Trp Asp Arg Gly 
                405                 410                 415     


Ser Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  561
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  561

Met Ala Lys Cys Pro Gln Ala Leu Leu Ala Ile Phe Trp Leu Leu Leu 
1               5                   10                  15      


Ser Trp Val Ser Ser Glu Asp Lys Val Val Gln Ser Pro Leu Ser Leu 
            20                  25                  30          


Val Val His Glu Gly Asp Thr Val Thr Leu Asn Cys Ser Tyr Glu Val 
        35                  40                  45              


Thr Asn Phe Arg Ser Leu Leu Trp Tyr Lys Gln Glu Lys Lys Ala Pro 
    50                  55                  60                  


Thr Phe Leu Phe Met Leu Thr Ser Ser Gly Ile Glu Lys Lys Ser Gly 
65                  70                  75                  80  


Arg Leu Ser Ser Ile Leu Asp Lys Lys Glu Leu Ser Ser Ile Leu Asn 
                85                  90                  95      


Ile Thr Ala Thr Gln Thr Gly Asp Ser Ala Ile Tyr Leu Cys Ala Gly 
            100                 105                 110         


Gln Asn Tyr Gly Gly Ser Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Trp Leu Val 
    290                 295                 300                 


Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala Gly Leu Thr Glu Pro Glu 
305                 310                 315                 320 


Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly Gln Glu Val 
                325                 330                 335     


Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe Tyr Trp Tyr 
            340                 345                 350         


Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser Phe Tyr Asn 
        355                 360                 365             


Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln Phe Ser Val 
    370                 375                 380                 


Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg Ser Thr Lys 
385                 390                 395                 400 


Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Arg Asp Pro Ala Tyr 
                405                 410                 415     


Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu 
            420                 425                 430         


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
        435                 440                 445             


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
    450                 455                 460                 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
465                 470                 475                 480 


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
                485                 490                 495     


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
            500                 505                 510         


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
        515                 520                 525             


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
    530                 535                 540                 


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
545                 550                 555                 560 


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
                565                 570                 575     


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
            580                 585                 590         


Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600         


<210>  562
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  562

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Asn Pro Pro Val Lys Thr Ser Tyr Asp Lys Val Ile Phe Gly Pro Gly 
        115                 120                 125             


Thr Ser Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
        275                 280                 285             


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Ser Leu 
    290                 295                 300                 


Leu Cys Trp Val Val Leu Gly Phe Leu Gly Thr Asp His Thr Gly Ala 
305                 310                 315                 320 


Gly Val Ser Gln Ser Pro Arg Tyr Lys Val Thr Lys Arg Gly Gln Asp 
                325                 330                 335     


Val Ala Leu Arg Cys Asp Pro Ile Ser Gly His Val Ser Leu Tyr Trp 
            340                 345                 350         


Tyr Arg Gln Ala Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Asn 
        355                 360                 365             


Tyr Glu Ala Gln Gln Asp Lys Ser Gly Leu Pro Asn Asp Arg Phe Ser 
    370                 375                 380                 


Ala Glu Arg Pro Glu Gly Ser Ile Ser Thr Leu Thr Ile Gln Arg Thr 
385                 390                 395                 400 


Glu Gln Arg Asp Ser Ala Met Tyr Arg Cys Ala Ser Ser His Arg Glu 
                405                 410                 415     


Pro His Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg Leu Thr Val 
            420                 425                 430         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        435                 440                 445             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    450                 455                 460                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
465                 470                 475                 480 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
                485                 490                 495     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            500                 505                 510         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        515                 520                 525             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    530                 535                 540                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
545                 550                 555                 560 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                565                 570                 575     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            580                 585                 590         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605     


<210>  563
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  563

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Thr Leu Cys Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ala Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Asn Gln Val Leu Cys 
    290                 295                 300                 


Cys Val Val Leu Cys Phe Leu Gly Ala Asn Thr Val Asp Gly Gly Ile 
305                 310                 315                 320 


Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn Val Thr 
                325                 330                 335     


Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln Ile Val 
        355                 360                 365             


Asn Asp Phe Gln Lys Gly Asp Ile Val Glu Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln Lys Asn 
385                 390                 395                 400 


Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ser Arg Asp Tyr Glu Gln 
                405                 410                 415     


Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn 
            420                 425                 430         


Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile 
        435                 440                 445             


Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
    450                 455                 460                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
465                 470                 475                 480 


Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
                485                 490                 495     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
            500                 505                 510         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
        515                 520                 525             


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
    530                 535                 540                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
545                 550                 555                 560 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                565                 570                 575     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
            580                 585                 590         


Ala Met Val Lys Arg Lys Asn Ser 
        595                 600 


<210>  564
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  564

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Thr Leu Ser Gly Gly Tyr Asn Lys Leu Ile Phe Gly Ala Gly Thr Arg 
        115                 120                 125             


Leu Ala Val His Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Asn Gln Val Leu Cys 
    290                 295                 300                 


Cys Val Val Leu Cys Phe Leu Gly Ala Asn Thr Val Asp Gly Gly Ile 
305                 310                 315                 320 


Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn Val Thr 
                325                 330                 335     


Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln Ile Val 
        355                 360                 365             


Asn Asp Phe Gln Lys Gly Asp Ile Val Glu Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Glu Lys Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln Lys Asn 
385                 390                 395                 400 


Pro Thr Ala Phe Tyr Leu Cys Ala Ser Ser Ser Arg Asp Tyr Glu Gln 
                405                 410                 415     


Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn 
            420                 425                 430         


Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile 
        435                 440                 445             


Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
    450                 455                 460                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
465                 470                 475                 480 


Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
                485                 490                 495     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
            500                 505                 510         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
        515                 520                 525             


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
    530                 535                 540                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
545                 550                 555                 560 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                565                 570                 575     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
            580                 585                 590         


Ala Met Val Lys Arg Lys Asn Ser 
        595                 600 


<210>  565
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  565

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Val Trp Asp Tyr Lys Leu Ser Phe Gly Ala Gly Thr Thr Val Thr 
        115                 120                 125             


Val Arg Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
            260                 265                 270         


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met His Asn Gln Val Leu Cys Cys Val 
    290                 295                 300                 


Val Leu Cys Phe Leu Gly Ala Asn Thr Val Asp Gly Gly Ile Thr Gln 
305                 310                 315                 320 


Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn Val Thr Leu Ser 
                325                 330                 335     


Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp Tyr Arg Gln Asp 
            340                 345                 350         


Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln Ile Val Asn Asp 
        355                 360                 365             


Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val Ser Arg Glu Lys 
    370                 375                 380                 


Lys Glu Ser Phe Pro Leu Thr Val Thr Ser Ala Gln Lys Asn Pro Thr 
385                 390                 395                 400 


Ala Phe Tyr Leu Cys Ala Ser Ser Ile Ser Ala Gly Gly Asp Gly Tyr 
                405                 410                 415     


Thr Phe Gly Ser Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn 
            420                 425                 430         


Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile 
        435                 440                 445             


Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe 
    450                 455                 460                 


Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His 
465                 470                 475                 480 


Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser 
                485                 490                 495     


Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn 
            500                 505                 510         


Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu 
        515                 520                 525             


Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile 
    530                 535                 540                 


Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser 
545                 550                 555                 560 


Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu 
                565                 570                 575     


Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met 
            580                 585                 590         


Ala Met Val Lys Arg Lys Asn Ser 
        595                 600 


<210>  566
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  566

Met Ala Met Leu Leu Gly Ala Ser Val Leu Ile Leu Trp Leu Gln Pro 
1               5                   10                  15      


Asp Trp Val Asn Ser Gln Gln Lys Asn Asp Asp Gln Gln Val Lys Gln 
            20                  25                  30          


Asn Ser Pro Ser Leu Ser Val Gln Glu Gly Arg Ile Ser Ile Leu Asn 
        35                  40                  45              


Cys Asp Tyr Thr Asn Ser Met Phe Asp Tyr Phe Leu Trp Tyr Lys Lys 
    50                  55                  60                  


Tyr Pro Ala Glu Gly Pro Thr Phe Leu Ile Ser Ile Ser Ser Ile Lys 
65                  70                  75                  80  


Asp Lys Asn Glu Asp Gly Arg Phe Thr Val Phe Leu Asn Lys Ser Ala 
                85                  90                  95      


Lys His Leu Ser Leu His Ile Val Pro Ser Gln Pro Gly Asp Ser Ala 
            100                 105                 110         


Val Tyr Phe Cys Ala Ala Asn Thr Gly Asn Gln Phe Tyr Phe Gly Thr 
        115                 120                 125             


Gly Thr Ser Leu Thr Val Ile Pro Asn Ile Gln Asn Pro Glu Pro Ala 
    130                 135                 140                 


Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu 
145                 150                 155                 160 


Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser 
                165                 170                 175     


Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp 
            180                 185                 190         


Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr 
        195                 200                 205             


Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp 
    210                 215                 220                 


Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg 
    290                 295                 300                 


Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Glu Leu Thr Glu 
305                 310                 315                 320 


Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln 
                325                 330                 335     


Ser Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr 
            340                 345                 350         


Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe 
        355                 360                 365             


Gln Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe 
    370                 375                 380                 


Ser Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro 
385                 390                 395                 400 


Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser His Leu 
                405                 410                 415     


Ala Gly Glu Phe Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            420                 425                 430         


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
        435                 440                 445             


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
    450                 455                 460                 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
465                 470                 475                 480 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                485                 490                 495     


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
            500                 505                 510         


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
        515                 520                 525             


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
    530                 535                 540                 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
545                 550                 555                 560 


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                565                 570                 575     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            580                 585                 590         


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605             


<210>  567
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  567

Met Ala Gly Ala Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Ala Gly Gln Ser Leu Glu Gln Pro Ser Glu Val Thr Ala Val Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Tyr Gly 
        35                  40                  45              


Leu Ser Trp Tyr Gln Gln His Asp Gly Gly Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Ala Leu Asp Gly Leu Glu Glu Thr Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Asp Ser Tyr Gly Tyr Leu Leu Leu Gln Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Phe Cys Ala Phe Ala Tyr Gly Gln Asn 
            100                 105                 110         


Phe Val Phe Gly Pro Gly Thr Arg Leu Ser Val Leu Pro Asn Ile Gln 
        115                 120                 125             


Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp 
    130                 135                 140                 


Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro 
145                 150                 155                 160 


Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp 
                165                 170                 175     


Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn 
            180                 185                 190         


Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr 
        195                 200                 205             


Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser 
    210                 215                 220                 


Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val 
225                 230                 235                 240 


Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr 
                245                 250                 255     


Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr 
            260                 265                 270         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        275                 280                 285             


Pro Met His Phe Arg Leu Leu Cys Cys Val Ala Phe Cys Leu Leu Gly 
    290                 295                 300                 


Ala Gly Pro Val Asp Ser Gly Val Thr Gln Thr Pro Lys His Leu Ile 
305                 310                 315                 320 


Thr Ala Thr Gly Gln Arg Val Thr Leu Arg Cys Ser Pro Arg Ser Gly 
                325                 330                 335     


Asp Leu Ser Val Tyr Trp Tyr Gln Gln Ser Leu Asp Gln Gly Leu Gln 
            340                 345                 350         


Phe Leu Ile Gln Tyr Tyr Asn Gly Glu Glu Arg Ala Lys Gly Asn Ile 
        355                 360                 365             


Leu Glu Arg Phe Ser Ala Gln Gln Phe Pro Asp Leu His Ser Glu Leu 
    370                 375                 380                 


Asn Leu Ser Ser Leu Glu Leu Gly Asp Ser Ala Leu Tyr Phe Cys Ala 
385                 390                 395                 400 


Ser Ser Pro Leu Gly Asp Ser Gly Asn Thr Ile Tyr Phe Gly Glu Gly 
                405                 410                 415     


Ser Trp Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
            420                 425                 430         


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
        435                 440                 445             


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
    450                 455                 460                 


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
465                 470                 475                 480 


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
                485                 490                 495     


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
            500                 505                 510         


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
        515                 520                 525             


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
    530                 535                 540                 


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
545                 550                 555                 560 


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
                565                 570                 575     


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
            580                 585                 590         


Lys Asn Ser 
        595 


<210>  568
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  568

Met Ala Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
        35                  40                  45              


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
    50                  55                  60                  


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
                85                  90                  95      


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Ala Thr Asp 
            100                 105                 110         


Ala Trp Asn Asn Asp Met Arg Phe Gly Ala Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser 
            260                 265                 270         


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        275                 280                 285             


Glu Glu Asn Pro Gly Pro Met His Ile Gly Leu Leu Cys Cys Val Ala 
    290                 295                 300                 


Phe Ser Leu Leu Trp Ala Ser Pro Val Asn Ala Gly Val Thr Gln Thr 
305                 310                 315                 320 


Pro Lys Phe Gln Val Leu Lys Thr Gly Gln Ser Met Thr Leu Gln Cys 
                325                 330                 335     


Ala Gln Asp Met Asn His Asn Ser Met Tyr Trp Tyr Arg Gln Asp Pro 
            340                 345                 350         


Gly Met Gly Leu Arg Leu Ile Tyr Tyr Ser Ala Ser Glu Gly Thr Thr 
        355                 360                 365             


Asp Lys Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg Leu Asn Lys 
    370                 375                 380                 


Arg Glu Phe Ser Leu Arg Leu Glu Ser Ala Ala Pro Ser Gln Thr Ser 
385                 390                 395                 400 


Val Tyr Phe Cys Ala Ser Ser Glu Ser Gln Gly Asn Thr Glu Ala Phe 
                405                 410                 415     


Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val 
            420                 425                 430         


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
        435                 440                 445             


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
    450                 455                 460                 


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
465                 470                 475                 480 


Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr 
                485                 490                 495     


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
            500                 505                 510         


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
        515                 520                 525             


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
    530                 535                 540                 


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
545                 550                 555                 560 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
                565                 570                 575     


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala 
            580                 585                 590         


Met Val Lys Arg Lys Asn Ser 
        595                 


<210>  569
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  569

Met Ala Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ser Tyr Lys Ile Ile Phe Gly Thr Gly Thr Arg Leu His Val 
        115                 120                 125             


Phe Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser 
            260                 265                 270         


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        275                 280                 285             


Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu Phe Trp Val Ala 
    290                 295                 300                 


Phe Cys Leu Leu Gly Ala Tyr His Thr Gly Ala Gly Val Ser Gln Ser 
305                 310                 315                 320 


Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp Val Glu Leu Arg Cys 
                325                 330                 335     


Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu 
            340                 345                 350         


Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro 
        355                 360                 365             


Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly 
    370                 375                 380                 


Glu Ser Val Ser Thr Leu Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser 
385                 390                 395                 400 


Ala Val Tyr Leu Cys Ala Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro 
                405                 410                 415     


Leu His Phe Gly Asn Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg 
            420                 425                 430         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        435                 440                 445             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                485                 490                 495     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            500                 505                 510         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        515                 520                 525             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    530                 535                 540                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
545                 550                 555                 560 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                565                 570                 575     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            580                 585                 590         


Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600     


<210>  570
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  570

Met Ala Lys His Leu Thr Thr Phe Leu Val Ile Leu Trp Leu Tyr Phe 
1               5                   10                  15      


Tyr Arg Gly Asn Gly Lys Asn Gln Val Glu Gln Ser Pro Gln Ser Leu 
            20                  25                  30          


Ile Ile Leu Glu Gly Lys Asn Cys Thr Leu Gln Cys Asn Tyr Thr Val 
        35                  40                  45              


Ser Pro Phe Ser Asn Leu Arg Trp Tyr Lys Gln Asp Thr Gly Arg Gly 
    50                  55                  60                  


Pro Val Ser Leu Thr Ile Met Thr Phe Ser Glu Asn Thr Lys Ser Asn 
65                  70                  75                  80  


Gly Arg Tyr Thr Ala Thr Leu Asp Ala Asp Thr Lys Gln Ser Ser Leu 
                85                  90                  95      


His Ile Thr Ala Ser Gln Leu Ser Asp Ser Ala Ser Tyr Ile Cys Val 
            100                 105                 110         


Val Ser Ser Tyr Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln Val 
        115                 120                 125             


Phe Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser 
            260                 265                 270         


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        275                 280                 285             


Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu Phe Trp Val Ala 
    290                 295                 300                 


Phe Cys Leu Leu Gly Ala Tyr His Thr Gly Ala Gly Val Ser Gln Ser 
305                 310                 315                 320 


Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Asp Val Glu Leu Arg Cys 
                325                 330                 335     


Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp Tyr Arg Gln Arg Leu 
            340                 345                 350         


Gly Gln Gly Leu Glu Phe Leu Ile Tyr Phe Gln Gly Asn Ser Ala Pro 
        355                 360                 365             


Asp Lys Ser Gly Leu Pro Ser Asp Arg Phe Ser Ala Glu Arg Thr Gly 
    370                 375                 380                 


Glu Ser Val Ser Thr Leu Thr Ile Gln Arg Thr Gln Gln Glu Asp Ser 
385                 390                 395                 400 


Ala Val Tyr Leu Cys Ala Ser Ser Pro Ile Gln Gly Glu Asn Ser Pro 
                405                 410                 415     


Leu His Phe Gly Asn Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg 
            420                 425                 430         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        435                 440                 445             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                485                 490                 495     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            500                 505                 510         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        515                 520                 525             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    530                 535                 540                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
545                 550                 555                 560 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                565                 570                 575     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            580                 585                 590         


Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600     


<210>  571
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  571

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Lys Gly Thr Gly Ala Gln Lys Leu Val Phe Gly Gln Gly Thr Arg 
        115                 120                 125             


Leu Thr Ile Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Asn Gln Val Leu Cys 
    290                 295                 300                 


Cys Val Val Leu Cys Phe Leu Gly Ala Asn Thr Val Asp Gly Gly Ile 
305                 310                 315                 320 


Thr Gln Ser Pro Lys Tyr Leu Phe Arg Lys Glu Gly Gln Asn Val Thr 
                325                 330                 335     


Leu Ser Cys Glu Gln Asn Leu Asn His Asp Ala Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Gln Gly Leu Arg Leu Ile Tyr Tyr Ser Gln Ile Val 
        355                 360                 365             


Asn Asp Phe Gln Lys Gly Asp Ile Ala Glu Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Glu Lys Lys Glu Ser Phe Pro Leu Ile Val Thr Ser Ala Gln Lys Asn 
385                 390                 395                 400 


Pro Thr Ala Ser Tyr Leu Cys Ala Ser Glu Ala Phe Phe Gly Gln Gly 
                405                 410                 415     


Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
            420                 425                 430         


Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
        435                 440                 445             


Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
    450                 455                 460                 


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
465                 470                 475                 480 


Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
                485                 490                 495     


Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
            500                 505                 510         


Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
        515                 520                 525             


Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
    530                 535                 540                 


Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val 
545                 550                 555                 560 


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
                565                 570                 575     


Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg 
            580                 585                 590         


Lys Asn Ser 
        595 


<210>  572
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  572

Met Ala Leu Val Thr Ser Ile Thr Val Leu Leu Ser Leu Gly Ile Met 
1               5                   10                  15      


Gly Asp Ala Lys Thr Thr Gln Pro Asn Ser Met Glu Ser Asn Glu Glu 
            20                  25                  30          


Glu Pro Val His Leu Pro Cys Asn His Ser Thr Ile Ser Gly Thr Asp 
        35                  40                  45              


Tyr Ile His Trp Tyr Arg Gln Leu Pro Ser Gln Gly Pro Glu Tyr Val 
    50                  55                  60                  


Ile His Gly Leu Thr Ser Asn Val Asn Asn Arg Met Ala Ser Leu Ala 
65                  70                  75                  80  


Ile Ala Glu Asp Arg Lys Ser Ser Thr Leu Ile Leu His Arg Ala Thr 
                85                  90                  95      


Leu Arg Asp Ala Ala Val Tyr Tyr Cys Ile Leu Ala Ser Gly Ala Gly 
            100                 105                 110         


Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr Lys Leu Ser Val Ile Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met His Cys Arg Leu Leu Cys Cys Val Val Phe Cys 
    290                 295                 300                 


Leu Leu Gln Ala Gly Pro Leu Asp Thr Ala Val Ser Gln Thr Pro Lys 
305                 310                 315                 320 


Tyr Leu Val Thr Gln Met Gly Asn Asp Lys Ser Ile Lys Cys Glu Gln 
                325                 330                 335     


Asn Leu Gly His Asp Thr Met Tyr Trp Tyr Lys Gln Asp Ser Lys Lys 
            340                 345                 350         


Phe Leu Lys Ile Met Phe Ser Tyr Asn Asn Lys Glu Leu Ile Ile Asn 
        355                 360                 365             


Glu Thr Val Pro Asn Arg Phe Ser Pro Lys Ser Pro Asp Lys Ala His 
    370                 375                 380                 


Leu Asn Leu His Ile Asn Ser Leu Glu Leu Gly Asp Ser Ala Val Tyr 
385                 390                 395                 400 


Phe Cys Ala Ser Arg Thr Ile Gly Tyr Asn Thr Glu Ala Phe Phe Gly 
                405                 410                 415     


Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro 
            420                 425                 430         


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
        435                 440                 445             


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
    450                 455                 460                 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
465                 470                 475                 480 


Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
                485                 490                 495     


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
            500                 505                 510         


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
        515                 520                 525             


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
    530                 535                 540                 


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
545                 550                 555                 560 


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
                565                 570                 575     


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
            580                 585                 590         


Lys Arg Lys Asn Ser 
        595         


<210>  573
<211>  602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  573

Met Ala Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Ala Leu 
            100                 105                 110         


Ser Tyr Asn Thr Asp Lys Leu Ile Phe Gly Thr Gly Thr Arg Leu Gln 
        115                 120                 125             


Val Phe Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
            260                 265                 270         


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
        275                 280                 285             


Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu Cys Trp Ala 
    290                 295                 300                 


Ala Leu Cys Leu Leu Gly Ala Asp His Thr Gly Ala Gly Val Ser Gln 
305                 310                 315                 320 


Thr Pro Ser Asn Lys Val Thr Glu Lys Gly Lys Tyr Val Glu Leu Arg 
                325                 330                 335     


Cys Asp Pro Ile Ser Gly His Thr Ala Leu Tyr Trp Tyr Arg Gln Ser 
            340                 345                 350         


Leu Gly Gln Gly Pro Glu Phe Leu Ile Tyr Phe Gln Gly Thr Gly Ala 
        355                 360                 365             


Ala Asp Asp Ser Gly Leu Pro Asn Asp Arg Phe Phe Ala Val Arg Pro 
    370                 375                 380                 


Glu Gly Ser Val Ser Thr Leu Lys Ile Gln Arg Thr Glu Arg Gly Asp 
385                 390                 395                 400 


Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Ser Gly Leu Leu Gln Glu 
                405                 410                 415     


Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu 
            420                 425                 430         


Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala 
        435                 440                 445             


Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly 
    450                 455                 460                 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
465                 470                 475                 480 


Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn 
                485                 490                 495     


Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
            500                 505                 510         


His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu 
        515                 520                 525             


Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln 
    530                 535                 540                 


Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser 
545                 550                 555                 560 


Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
                565                 570                 575     


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val 
            580                 585                 590         


Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600         


<210>  574
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  574

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


His Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu 
    290                 295                 300                 


Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Glu Leu Thr Glu Ala Gly 
305                 310                 315                 320 


Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser Val 
                325                 330                 335     


Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp Tyr 
            340                 345                 350         


Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln Asn 
        355                 360                 365             


Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser Ala 
    370                 375                 380                 


Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala Lys 
385                 390                 395                 400 


Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Thr Gly Gly Gly 
                405                 410                 415     


Arg His Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  575
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  575

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Gln Thr Gly Ser Ser Lys Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu 
    290                 295                 300                 


Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Glu Leu Thr Glu Ala Gly 
305                 310                 315                 320 


Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser Val 
                325                 330                 335     


Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp Tyr 
            340                 345                 350         


Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln Asn 
        355                 360                 365             


Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser Ala 
    370                 375                 380                 


Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala Lys 
385                 390                 395                 400 


Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Thr Gly Gly Gly 
                405                 410                 415     


Arg His Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  576
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  576

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Gln Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Arg Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu 
    290                 295                 300                 


Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Glu Leu Thr Glu Ala Gly 
305                 310                 315                 320 


Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser Val 
                325                 330                 335     


Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp Tyr 
            340                 345                 350         


Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln Asn 
        355                 360                 365             


Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser Ala 
    370                 375                 380                 


Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala Lys 
385                 390                 395                 400 


Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Thr Gly Gly Gly 
                405                 410                 415     


Arg His Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  577
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  577

Met Ala Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      


Arg Thr Arg Gly Asn Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          


Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              


Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  


Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      


Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Ser 
            100                 105                 110         


Thr Thr Gly Ser Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Gln Val Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Leu 
    290                 295                 300                 


Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Glu Leu Thr Glu Ala Gly 
305                 310                 315                 320 


Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser Val 
                325                 330                 335     


Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp Tyr 
            340                 345                 350         


Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln Asn 
        355                 360                 365             


Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser Ala 
    370                 375                 380                 


Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala Lys 
385                 390                 395                 400 


Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Thr Gly Gly Gly 
                405                 410                 415     


Arg His Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu 
            420                 425                 430         


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
        435                 440                 445             


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
    450                 455                 460                 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
465                 470                 475                 480 


Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys 
                485                 490                 495     


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
            500                 505                 510         


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
        515                 520                 525             


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
    530                 535                 540                 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
545                 550                 555                 560 


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
                565                 570                 575     


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
            580                 585                 590         


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605 


<210>  578
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  578

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Val 
            100                 105                 110         


Ser Trp Tyr Ser Thr Leu Thr Phe Gly Lys Gly Thr Met Leu Leu Val 
        115                 120                 125             


Ser Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser 
            260                 265                 270         


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        275                 280                 285             


Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu Phe Phe Tyr Val Ala 
    290                 295                 300                 


Leu Cys Leu Leu Trp Ala Gly His Arg Asp Ala Gly Ile Thr Gln Ser 
305                 310                 315                 320 


Pro Arg Tyr Lys Ile Thr Glu Thr Gly Arg Gln Val Thr Leu Met Cys 
                325                 330                 335     


His Gln Thr Trp Ser His Ser Tyr Met Phe Trp Tyr Arg Gln Asp Leu 
            340                 345                 350         


Gly His Gly Leu Arg Leu Ile Tyr Tyr Ser Ala Ala Ala Asp Ile Thr 
        355                 360                 365             


Asp Lys Gly Glu Val Pro Asp Gly Tyr Val Val Ser Arg Ser Lys Thr 
    370                 375                 380                 


Glu Asn Phe Pro Leu Thr Leu Glu Ser Ala Thr Arg Ser Gln Thr Ser 
385                 390                 395                 400 


Val Tyr Phe Cys Ala Ser Ser Gly Ser Arg Thr Asp Thr Gln Tyr Phe 
                405                 410                 415     


Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  579
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  579

Met Ala Leu Lys Phe Ser Val Ser Ile Leu Trp Ile Gln Leu Ala Trp 
1               5                   10                  15      


Val Ser Thr Gln Leu Leu Glu Gln Ser Pro Gln Phe Leu Ser Ile Gln 
            20                  25                  30          


Glu Gly Glu Asn Leu Thr Val Tyr Cys Asn Ser Ser Ser Val Phe Ser 
        35                  40                  45              


Ser Leu Gln Trp Tyr Arg Gln Glu Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  


Val Thr Val Val Thr Gly Gly Glu Val Lys Lys Leu Lys Arg Leu Thr 
65                  70                  75                  80  


Phe Gln Phe Gly Asp Ala Arg Lys Asp Ser Ser Leu His Ile Thr Ala 
                85                  90                  95      


Ala Gln Pro Gly Asp Thr Gly Leu Tyr Leu Cys Ala Gly Glu Phe Ala 
            100                 105                 110         


Gly Asn Gln Phe Tyr Phe Gly Thr Gly Thr Ser Leu Thr Val Ile Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met His Cys Arg Leu Leu Cys Cys Ala Val Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Val Pro Ile Asp Thr Glu Val Thr Gln Thr Pro Lys 
305                 310                 315                 320 


His Leu Val Met Gly Met Thr Asn Lys Lys Ser Leu Lys Cys Glu Gln 
                325                 330                 335     


His Met Gly His Arg Ala Met Tyr Trp Tyr Lys Gln Lys Ala Lys Lys 
            340                 345                 350         


Pro Pro Glu Leu Met Phe Val Tyr Ser Tyr Glu Lys Leu Ser Ile Asn 
        355                 360                 365             


Glu Ser Val Pro Ser Arg Phe Ser Pro Glu Cys Pro Asn Ser Ser Leu 
    370                 375                 380                 


Leu Asn Leu His Leu His Ala Leu Gln Pro Glu Asp Ser Ala Leu Tyr 
385                 390                 395                 400 


Leu Cys Ala Ser Ser Gln Val Gly Leu Thr Tyr Glu Gln Tyr Phe Gly 
                405                 410                 415     


Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro 
            420                 425                 430         


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
        435                 440                 445             


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
    450                 455                 460                 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
465                 470                 475                 480 


Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
                485                 490                 495     


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
            500                 505                 510         


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
        515                 520                 525             


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
    530                 535                 540                 


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
545                 550                 555                 560 


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
                565                 570                 575     


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
            580                 585                 590         


Lys Arg Lys Asn Ser 
        595         


<210>  580
<211>  604
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  580

Met Ala Ser Ala Pro Ile Ser Met Leu Ala Met Leu Phe Thr Leu Ser 
1               5                   10                  15      


Gly Leu Arg Ala Gln Ser Val Ala Gln Pro Glu Asp Gln Val Asn Val 
            20                  25                  30          


Ala Glu Gly Asn Pro Leu Thr Val Lys Cys Thr Tyr Ser Val Ser Gly 
        35                  40                  45              


Asn Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Arg Gly Leu Gln 
    50                  55                  60                  


Phe Leu Leu Lys Tyr Ile Thr Gly Asp Asn Leu Val Lys Gly Ser Tyr 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Lys 
                85                  90                  95      


Lys Pro Ser Ala Leu Val Ser Asp Ser Ala Leu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Asp Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly 
        115                 120                 125             


Thr Leu Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly 
                165                 170                 175     


Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser 
            180                 185                 190         


Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys 
        195                 200                 205             


Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val 
    210                 215                 220                 


Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn 
225                 230                 235                 240 


Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu 
                245                 250                 255     


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270         


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
        275                 280                 285             


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Thr Arg Leu 
    290                 295                 300                 


Leu Cys Trp Ala Ala Leu Cys Leu Leu Gly Ala Glu Leu Thr Glu Ala 
305                 310                 315                 320 


Gly Val Ala Gln Ser Pro Arg Tyr Lys Ile Ile Glu Lys Arg Gln Ser 
                325                 330                 335     


Val Ala Phe Trp Cys Asn Pro Ile Ser Gly His Ala Thr Leu Tyr Trp 
            340                 345                 350         


Tyr Gln Gln Ile Leu Gly Gln Gly Pro Lys Leu Leu Ile Gln Phe Gln 
        355                 360                 365             


Asn Asn Gly Val Val Asp Asp Ser Gln Leu Pro Lys Asp Arg Phe Ser 
    370                 375                 380                 


Ala Glu Arg Leu Lys Gly Val Asp Ser Thr Leu Lys Ile Gln Pro Ala 
385                 390                 395                 400 


Lys Leu Glu Asp Ser Ala Val Tyr Leu Cys Ala Ser Ser Leu Gly Gln 
                405                 410                 415     


Gly Gln Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu 
            420                 425                 430         


Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser 
        435                 440                 445             


Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala 
    450                 455                 460                 


Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
465                 470                 475                 480 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu 
                485                 490                 495     


Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr 
            500                 505                 510         


Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His 
        515                 520                 525             


Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val 
    530                 535                 540                 


Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile 
545                 550                 555                 560 


Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr 
                565                 570                 575     


Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr 
            580                 585                 590         


Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 


<210>  581
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  581

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Arg Gly Ser Ser Gly Thr Tyr Lys Tyr Ile Phe Gly Thr Gly Thr Arg 
        115                 120                 125             


Leu Lys Val Leu Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Ile Arg Leu Leu Cys 
    290                 295                 300                 


Arg Val Ala Phe Cys Phe Leu Ala Val Gly Leu Val Asp Val Lys Val 
305                 310                 315                 320 


Thr Gln Ser Ser Arg Tyr Leu Val Lys Arg Thr Gly Glu Lys Val Phe 
                325                 330                 335     


Leu Glu Cys Val Gln Asp Met Asp His Glu Asn Met Phe Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Leu Gly Leu Arg Leu Ile Tyr Phe Ser Tyr Asp Val 
        355                 360                 365             


Lys Met Lys Glu Lys Gly Asp Ile Pro Glu Gly Tyr Ser Val Ser Arg 
    370                 375                 380                 


Glu Lys Lys Glu Arg Phe Ser Leu Ile Leu Glu Ser Ala Ser Thr Asn 
385                 390                 395                 400 


Gln Thr Ser Met Tyr Leu Cys Ala Ser Lys Gly Asp Gln Asn Thr Glu 
                405                 410                 415     


Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg 
            420                 425                 430         


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
        435                 440                 445             


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
    450                 455                 460                 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
465                 470                 475                 480 


His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
                485                 490                 495     


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
            500                 505                 510         


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
        515                 520                 525             


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
    530                 535                 540                 


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
545                 550                 555                 560 


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
                565                 570                 575     


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
            580                 585                 590         


Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600     


<210>  582
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  582

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Arg Asp Leu Gln Thr 
            100                 105                 110         


Gly Ala Asn Asn Leu Phe Phe Gly Thr Gly Thr Arg Leu Thr Val Ile 
        115                 120                 125             


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
    130                 135                 140                 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
                165                 170                 175     


Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
            180                 185                 190         


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
        195                 200                 205             


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
    210                 215                 220                 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly 
            260                 265                 270         


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
        275                 280                 285             


Glu Asn Pro Gly Pro Met His Ile Arg Leu Leu Cys Arg Val Ala Phe 
    290                 295                 300                 


Cys Phe Leu Ala Val Gly Leu Val Asp Val Lys Val Thr Gln Ser Ser 
305                 310                 315                 320 


Arg Tyr Leu Val Lys Arg Thr Gly Glu Lys Val Phe Leu Glu Cys Val 
                325                 330                 335     


Gln Asp Met Asp His Glu Asn Met Phe Trp Tyr Arg Gln Asp Pro Gly 
            340                 345                 350         


Leu Gly Leu Arg Leu Ile Tyr Phe Ser Tyr Asp Val Lys Met Lys Glu 
        355                 360                 365             


Lys Gly Asp Ile Pro Glu Gly Tyr Ser Val Ser Arg Glu Lys Lys Glu 
    370                 375                 380                 


Arg Phe Ser Leu Ile Leu Glu Ser Ala Ser Thr Asn Gln Thr Ser Met 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Thr Phe Gly Thr Thr Glu Ala Phe Phe 
                405                 410                 415     


Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr 
            420                 425                 430         


Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn 
        435                 440                 445             


Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp 
    450                 455                 460                 


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
465                 470                 475                 480 


Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys 
                485                 490                 495     


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg 
            500                 505                 510         


Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp 
        515                 520                 525             


Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala 
    530                 535                 540                 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln 
545                 550                 555                 560 


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
                565                 570                 575     


Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met 
            580                 585                 590         


Val Lys Arg Lys Asn Ser 
        595             


<210>  583
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  583

Met Ala Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      


Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          


Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              


Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      


Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Asp Leu Val Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg 
        115                 120                 125             


Leu His Ile Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Ile Gly Leu Leu Cys 
    290                 295                 300                 


Cys Val Ala Phe Ser Leu Leu Trp Ala Ser Pro Val Asn Ala Gly Val 
305                 310                 315                 320 


Thr Gln Thr Pro Lys Phe Gln Val Leu Lys Thr Gly Gln Ser Met Thr 
                325                 330                 335     


Leu Gln Cys Ala Gln Asp Met Asn His Asn Ser Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Met Gly Leu Arg Leu Ile Tyr Tyr Ser Ala Ser Glu 
        355                 360                 365             


Gly Thr Thr Asp Lys Gly Glu Val Pro Asn Gly Tyr Asn Val Ser Arg 
    370                 375                 380                 


Leu Asn Lys Arg Glu Phe Ser Leu Arg Leu Glu Ser Ala Ala Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ile Gly Gly Phe Glu Ala Phe 
                405                 410                 415     


Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val 
            420                 425                 430         


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
        435                 440                 445             


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
    450                 455                 460                 


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
465                 470                 475                 480 


Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr 
                485                 490                 495     


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
            500                 505                 510         


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
        515                 520                 525             


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
    530                 535                 540                 


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
545                 550                 555                 560 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
                565                 570                 575     


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala 
            580                 585                 590         


Met Val Lys Arg Lys Asn Ser 
        595                 


<210>  584
<211>  597
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  584

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Tyr Thr Gly Gly Phe 
            100                 105                 110         


Lys Thr Ile Phe Gly Ala Gly Thr Arg Leu Phe Val Lys Ala Asn Ile 
        115                 120                 125             


Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln 
    130                 135                 140                 


Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val 
145                 150                 155                 160 


Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu 
                165                 170                 175     


Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser 
            180                 185                 190         


Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala 
        195                 200                 205             


Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys 
    210                 215                 220                 


Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile 
225                 230                 235                 240 


Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
                245                 250                 255     


Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala 
            260                 265                 270         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        275                 280                 285             


Gly Pro Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys Leu Leu 
    290                 295                 300                 


Gly Ala Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg Tyr Lys 
305                 310                 315                 320 


Ile Ile Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro Ile Ser 
                325                 330                 335     


Gly His Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln Gly Pro 
            340                 345                 350         


Lys Leu Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp Ser Gln 
        355                 360                 365             


Leu Pro Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val Asp Ser 
    370                 375                 380                 


Thr Leu Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val Tyr Leu 
385                 390                 395                 400 


Cys Ala Ser Asn Leu Gly Gly Gly Ser Thr Asp Thr Gln Tyr Phe Gly 
                405                 410                 415     


Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro 
            420                 425                 430         


Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys 
        435                 440                 445             


Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His 
    450                 455                 460                 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
465                 470                 475                 480 


Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu 
                485                 490                 495     


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn 
            500                 505                 510         


His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys 
        515                 520                 525             


Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu 
    530                 535                 540                 


Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln 
545                 550                 555                 560 


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
                565                 570                 575     


Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala Met Val 
            580                 585                 590         


Lys Arg Lys Asn Ser 
        595         


<210>  585
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  585

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Phe Tyr Tyr Gly Gly Ser 
            100                 105                 110         


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met His Thr Arg Leu Leu Cys Trp Val Val Leu Gly 
    290                 295                 300                 


Phe Leu Gly Thr Asp His Thr Gly Ala Gly Val Ser Gln Ser Pro Arg 
305                 310                 315                 320 


Tyr Lys Val Ala Lys Arg Gly Gln Asp Val Ala Leu Arg Cys Asp Pro 
                325                 330                 335     


Ile Ser Gly His Val Ser Leu Phe Trp Tyr Gln Gln Ala Leu Gly Gln 
            340                 345                 350         


Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Asp Lys 
        355                 360                 365             


Ser Gly Leu Pro Ser Asp Arg Phe Phe Ala Glu Arg Pro Glu Gly Ser 
    370                 375                 380                 


Val Ser Thr Leu Lys Ile Gln Arg Thr Gln Gln Glu Asp Ser Ala Val 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Phe Gly Ser Gly Ser Thr Asp Thr Gln Tyr 
                405                 410                 415     


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val 
            420                 425                 430         


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
        435                 440                 445             


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
    450                 455                 460                 


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
465                 470                 475                 480 


Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr 
                485                 490                 495     


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
            500                 505                 510         


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
        515                 520                 525             


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
    530                 535                 540                 


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
545                 550                 555                 560 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
                565                 570                 575     


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala 
            580                 585                 590         


Met Val Lys Arg Lys Asn Ser 
        595                 


<210>  586
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  586

Met Ala Gly Val Phe Leu Leu Tyr Val Ser Met Lys Met Gly Gly Thr 
1               5                   10                  15      


Thr Gly Gln Asn Ile Asp Gln Pro Thr Glu Met Thr Ala Thr Glu Gly 
            20                  25                  30          


Ala Ile Val Gln Ile Asn Cys Thr Tyr Gln Thr Ser Gly Phe Asn Gly 
        35                  40                  45              


Leu Phe Trp Tyr Gln Gln His Ala Gly Glu Ala Pro Thr Phe Leu Ser 
    50                  55                  60                  


Tyr Asn Val Leu Asp Gly Leu Glu Glu Lys Gly Arg Phe Ser Ser Phe 
65                  70                  75                  80  


Leu Ser Arg Ser Lys Gly Tyr Ser Tyr Leu Leu Leu Lys Glu Leu Gln 
                85                  90                  95      


Met Lys Asp Ser Ala Ser Tyr Leu Cys Ala Val Tyr Pro Gly Gly Ser 
            100                 105                 110         


Gln Gly Asn Leu Ile Phe Gly Lys Gly Thr Lys Leu Ser Val Lys Pro 
        115                 120                 125             


Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg 
    130                 135                 140                 


Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile 
145                 150                 155                 160 


Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Cys 
                165                 170                 175     


Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala 
            180                 185                 190         


Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr 
        195                 200                 205             


Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr 
    210                 215                 220                 


Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Leu 
225                 230                 235                 240 


Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
                245                 250                 255     


Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser 
            260                 265                 270         


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
        275                 280                 285             


Asn Pro Gly Pro Met His Thr Arg Leu Leu Cys Trp Ala Ala Leu Cys 
    290                 295                 300                 


Leu Leu Gly Ala Glu Leu Thr Glu Ala Gly Val Ala Gln Ser Pro Arg 
305                 310                 315                 320 


Tyr Lys Ile Ile Glu Lys Arg Gln Ser Val Ala Phe Trp Cys Asn Pro 
                325                 330                 335     


Ile Ser Gly His Ala Thr Leu Tyr Trp Tyr Gln Gln Ile Leu Gly Gln 
            340                 345                 350         


Gly Pro Lys Leu Leu Ile Gln Phe Gln Asn Asn Gly Val Val Asp Asp 
        355                 360                 365             


Ser Gln Leu Pro Lys Asp Arg Phe Ser Ala Glu Arg Leu Lys Gly Val 
    370                 375                 380                 


Asp Ser Thr Leu Lys Ile Gln Pro Ala Lys Leu Glu Asp Ser Ala Val 
385                 390                 395                 400 


Tyr Leu Cys Ala Ser Ser Leu Gly Thr Gly Ser Thr Asp Thr Gln Tyr 
                405                 410                 415     


Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val 
            420                 425                 430         


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
        435                 440                 445             


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
    450                 455                 460                 


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
465                 470                 475                 480 


Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr 
                485                 490                 495     


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
            500                 505                 510         


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
        515                 520                 525             


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
    530                 535                 540                 


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
545                 550                 555                 560 


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
                565                 570                 575     


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val Met Ala 
            580                 585                 590         


Met Val Lys Arg Lys Asn Ser 
        595                 


<210>  587
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  587

Met Ala Ser Ile Arg Ala Val Phe Ile Phe Leu Trp Leu Gln Leu Asp 
1               5                   10                  15      


Leu Val Asn Gly Glu Asn Val Glu Gln His Pro Ser Thr Leu Ser Val 
            20                  25                  30          


Gln Glu Gly Asp Ser Ala Val Ile Lys Cys Thr Tyr Ser Asp Ser Ala 
        35                  40                  45              


Ser Asn Tyr Phe Pro Trp Tyr Lys Gln Glu Leu Gly Lys Gly Pro Gln 
    50                  55                  60                  


Leu Ile Ile Asp Ile Arg Ser Asn Val Gly Glu Lys Lys Asp Gln Arg 
65                  70                  75                  80  


Ile Ala Val Thr Leu Asn Lys Thr Ala Lys His Phe Ser Leu His Ile 
                85                  90                  95      


Thr Glu Thr Gln Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ala Ser 
            100                 105                 110         


Lys Ser Ala Ile Met Val Val Leu Gln Thr Ser Ser Ser Leu Glu Leu 
        115                 120                 125             


Ala Leu Cys Leu Leu Ser Ser Gln Val Asn Ile Gln Asn Pro Glu Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu 
                165                 170                 175     


Ser Gly Thr Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met 
            180                 185                 190         


Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe 
        195                 200                 205             


Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser 
    210                 215                 220                 


Asp Val Pro Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Met Asn Leu Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        275                 280                 285             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Pro 
    290                 295                 300                 


Gln Leu Leu Gly Tyr Val Val Leu Cys Leu Leu Gly Ala Gly Pro Leu 
305                 310                 315                 320 


Glu Ala Gln Val Thr Gln Asn Pro Arg Tyr Leu Ile Thr Val Thr Gly 
                325                 330                 335     


Lys Lys Leu Thr Val Thr Cys Ser Gln Asn Met Asn His Glu Tyr Met 
            340                 345                 350         


Ser Trp Tyr Arg Gln Asp Pro Gly Leu Gly Leu Arg Gln Ile Tyr Tyr 
        355                 360                 365             


Ser Met Asn Val Glu Val Thr Asp Lys Gly Asp Val Pro Glu Gly Tyr 
    370                 375                 380                 


Lys Val Ser Arg Lys Glu Lys Arg Asn Phe Pro Leu Ile Leu Glu Ser 
385                 390                 395                 400 


Pro Ser Pro Asn Gln Thr Ser Leu Tyr Phe Cys Ala Ser Ser Ile Gln 
                405                 410                 415     


Gln Gly Ala Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val 
            420                 425                 430         


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
        435                 440                 445             


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
    450                 455                 460                 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
465                 470                 475                 480 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr 
                485                 490                 495     


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            500                 505                 510         


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        515                 520                 525             


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
    530                 535                 540                 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
545                 550                 555                 560 


Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                565                 570                 575     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            580                 585                 590         


Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600                 605     


<210>  588
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  588

Met Ala Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      


Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asn Ser Gly Pro Leu 
            20                  25                  30          


Ser Val Pro Glu Gly Ala Ile Ala Ser Leu Asn Cys Thr Tyr Ser Asp 
        35                  40                  45              


Arg Gly Ser Gln Ser Phe Phe Trp Tyr Arg Gln Tyr Ser Gly Lys Ser 
    50                  55                  60                  


Pro Glu Leu Ile Met Phe Ile Tyr Ser Asn Gly Asp Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Lys Ala Ser Gln Tyr Val Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala Trp 
            100                 105                 110         


Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu 
        115                 120                 125             


Leu Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         


Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             


Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 


Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 


Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     


Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala 
            260                 265                 270         


Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Gly Leu Leu Cys 
    290                 295                 300                 


Cys Gly Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Asn Ala Gly Val 
305                 310                 315                 320 


Thr Gln Thr Pro Lys Phe Arg Val Leu Lys Thr Gly Gln Ser Met Thr 
                325                 330                 335     


Leu Leu Cys Ala Gln Asp Met Asn His Glu Tyr Met Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly Glu 
        355                 360                 365             


Gly Thr Thr Ala Lys Gly Glu Val Pro Asp Gly Tyr Asn Val Ser Arg 
    370                 375                 380                 


Leu Lys Lys Gln Asn Phe Leu Leu Gly Leu Glu Ser Ala Ala Pro Ser 
385                 390                 395                 400 


Gln Thr Ser Val Tyr Phe Cys Ala Ser Ser Tyr Ser Gln Ala Trp Gly 
                405                 410                 415     


Gln Pro Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp 
            420                 425                 430         


Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys 
        435                 440                 445             


Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg 
    450                 455                 460                 


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
465                 470                 475                 480 


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser 
                485                 490                 495     


Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
            500                 505                 510         


Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly 
        515                 520                 525             


Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr 
    530                 535                 540                 


Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr 
545                 550                 555                 560 


Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
                565                 570                 575     


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu 
            580                 585                 590         


Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600             


<210>  589
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  589

Met Ala Lys Asn Pro Leu Ala Ala Pro Leu Leu Ile Leu Trp Phe His 
1               5                   10                  15      


Leu Asp Cys Val Ser Ser Ile Leu Asn Val Glu Gln Ser Pro Gln Ser 
            20                  25                  30          


Leu His Val Gln Glu Gly Asp Ser Thr Asn Phe Thr Cys Ser Phe Pro 
        35                  40                  45              


Ser Ser Asn Phe Tyr Ala Leu His Trp Tyr Arg Trp Glu Thr Ala Lys 
    50                  55                  60                  


Ser Pro Glu Ala Leu Phe Val Met Thr Leu Asn Gly Asp Glu Lys Lys 
65                  70                  75                  80  


Lys Gly Arg Ile Ser Ala Thr Leu Asn Thr Lys Glu Gly Tyr Ser Tyr 
                85                  90                  95      


Leu Tyr Ile Lys Gly Ser Gln Pro Glu Asp Ser Ala Thr Tyr Leu Cys 
            100                 105                 110         


Ala Leu Ile Thr Gly Gly Gly Asn Lys Leu Thr Phe Gly Thr Gly Thr 
        115                 120                 125             


Gln Leu Lys Val Glu Leu Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
                165                 170                 175     


Phe Ile Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys 
            180                 185                 190         


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
        195                 200                 205             


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
    210                 215                 220                 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
225                 230                 235                 240 


Asn Phe Gln Asn Leu Leu Val Ile Val Leu Arg Ile Leu Leu Leu Lys 
                245                 250                 255     


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
            260                 265                 270         


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
        275                 280                 285             


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met His Leu Gly Leu Leu 
    290                 295                 300                 


Cys Cys Gly Ala Phe Ser Leu Leu Trp Ala Gly Pro Val Asn Ala Gly 
305                 310                 315                 320 


Val Thr Gln Thr Pro Lys Phe Arg Val Leu Lys Thr Gly Gln Ser Met 
                325                 330                 335     


Thr Leu Leu Cys Ala Gln Asp Met Asn His Glu Tyr Met Tyr Trp Tyr 
            340                 345                 350         


Arg Gln Asp Pro Gly Met Gly Leu Arg Leu Ile His Tyr Ser Val Gly 
        355                 360                 365             


Glu Gly Thr Thr Ala Lys Gly Glu Val Pro Asp Gly Tyr Asn Val Ser 
    370                 375                 380                 


Arg Leu Lys Lys Gln Asn Phe Leu Leu Gly Leu Glu Ser Ala Ala Pro 
385                 390                 395                 400 


Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Arg Leu Gln Gly Trp Asn 
                405                 410                 415     


Ser Pro Leu His Phe Gly Asn Gly Thr Arg Leu Thr Val Thr Glu Asp 
            420                 425                 430         


Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys 
        435                 440                 445             


Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg 
    450                 455                 460                 


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
465                 470                 475                 480 


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Ala Tyr Lys Glu Ser 
                485                 490                 495     


Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
            500                 505                 510         


Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly 
        515                 520                 525             


Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr 
    530                 535                 540                 


Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr 
545                 550                 555                 560 


Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
                565                 570                 575     


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu 
            580                 585                 590         


Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
        595                 600             


<210>  590
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  590

Ser Ser Cys Met Gly Gly Met Asn Arg Arg 
1               5                   10  


<210>  591
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  591

Ser Ser Cys Met Gly Gly Met Asn Trp Arg 
1               5                   10  


<210>  592
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  592

Tyr Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro 
1               5                   10                  15  


<210>  593
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  593

Met Cys Asn Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro Ile 
1               5                   10                  15  


<210>  594
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  594

Cys Asn Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro Ile Leu 
1               5                   10                  15  


<210>  595
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  595

Asn Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro Ile Leu Thr 
1               5                   10                  15  


<210>  596
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  596

Ser Ser Cys Met Gly Gly Met Asn Trp Arg Pro Ile Leu Thr Ile 
1               5                   10                  15  


<210>  597
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  597

Ser Cys Met Gly Gly Met Asn Trp Arg Pro Ile Leu Thr Ile Ile 
1               5                   10                  15  


<210>  598
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  598

Cys Met Gly Gly Met Asn Trp Arg Pro Ile Leu Thr Ile Ile Thr 
1               5                   10                  15  


<210>  599
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  599

Met Gly Gly Met Asn Trp Arg Pro Ile Leu Thr Ile Ile Thr Leu 
1               5                   10                  15  


<210>  600
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  600

Gly Gly Met Asn Trp Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu 
1               5                   10                  15  


<210>  601
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  601

Gly Met Asn Trp Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp 
1               5                   10                  15  


<210>  602
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  602

Met Asn Trp Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
1               5                   10                  15  


