               SEQUENCE LISTING

<110> Universiteit Antwerpen

<120> Respiratory syncytial virus vaccination

<130> UNA-025

<150> EP17194098.4
<151> 2017-09-29

<160> 31

<170> BiSSAP 1.3.6

<210> 1
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F Wild-Type

<400> 1
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 2
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F Wild-Type

<400> 2
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgaac     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 3
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N27Q

<400> 3
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Gln Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 4
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N27Q

<400> 4
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagca gatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgaac     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 5
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N70Q

<400> 5
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Gln Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 6
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N70Q

<400> 6
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgccag ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgaac     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 7
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N116Q

<400> 7
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Gln Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 8
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N116Q

<400> 8
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgcagta taccctgaac     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 9
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N120Q

<400> 9
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Asn Tyr Thr Leu Gln Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 10
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N120Q

<400> 10
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgcag     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 11
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N126Q

<400> 11
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Gln Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Asn Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 12
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N126Q

<400> 12
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgaac     360

aataccaaga agacacaggt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 13
<211> 574
<212> PRT
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N500Q

<400> 13
Met Glu Leu Pro Ile Leu Lys Ala Asn Ala Ile Thr Thr Ile Leu Ala 
1               5                   10                  15      
Ala Val Thr Phe Cys Phe Ala Ser Ser Gln Asn Ile Thr Glu Glu Phe 
            20                  25                  30          
Tyr Gln Ser Thr Cys Ser Ala Val Ser Lys Gly Tyr Leu Ser Ala Leu 
        35                  40                  45              
Arg Thr Gly Trp Tyr Thr Ser Val Ile Thr Ile Glu Leu Ser Asn Ile 
    50                  55                  60                  
Lys Lys Asn Lys Cys Asn Gly Thr Asp Ala Lys Val Lys Leu Met Lys 
65                  70                  75                  80  
Gln Glu Leu Asp Lys Tyr Lys Asn Ala Val Thr Glu Leu Gln Leu Leu 
                85                  90                  95      
Met Gln Ser Thr Pro Ala Ala Asn Asn Arg Ala Arg Arg Glu Leu Pro 
            100                 105                 110         
Arg Phe Met Asn Tyr Thr Leu Asn Asn Thr Lys Lys Thr Asn Val Thr 
        115                 120                 125             
Leu Ser Lys Lys Arg Lys Arg Arg Phe Leu Gly Phe Leu Leu Gly Val 
    130                 135                 140                 
Gly Ser Ala Ile Ala Ser Gly Ile Ala Val Ser Lys Val Leu His Leu 
145                 150                 155                 160 
Glu Gly Glu Val Asn Lys Ile Lys Ser Ala Leu Leu Ser Thr Asn Lys 
                165                 170                 175     
Ala Val Val Ser Leu Ser Asn Gly Val Ser Val Leu Thr Ser Arg Val 
            180                 185                 190         
Leu Asp Leu Lys Asn Tyr Ile Asp Lys Gln Leu Leu Pro Ile Val Asn 
        195                 200                 205             
Lys Gln Ser Cys Arg Ile Ser Asn Ile Glu Thr Val Ile Glu Phe Gln 
    210                 215                 220                 
Gln Lys Asn Asn Arg Leu Leu Glu Ile Thr Arg Glu Phe Ser Val Asn 
225                 230                 235                 240 
Ala Gly Val Thr Thr Pro Val Ser Thr Tyr Met Leu Thr Asn Ser Glu 
                245                 250                 255     
Leu Leu Ser Leu Ile Asn Asp Met Pro Ile Thr Asn Asp Gln Lys Lys 
            260                 265                 270         
Leu Met Ser Asn Asn Val Gln Ile Val Arg Gln Gln Ser Tyr Ser Ile 
        275                 280                 285             
Met Ser Ile Ile Lys Glu Glu Val Leu Ala Tyr Val Val Gln Leu Pro 
    290                 295                 300                 
Leu Tyr Gly Val Ile Asp Thr Pro Cys Trp Lys Leu His Thr Ser Pro 
305                 310                 315                 320 
Leu Cys Thr Thr Asn Thr Lys Glu Gly Ser Asn Ile Cys Leu Thr Arg 
                325                 330                 335     
Thr Asp Arg Gly Trp Tyr Cys Asp Asn Ala Gly Ser Val Ser Phe Phe 
            340                 345                 350         
Pro Gln Ala Glu Lys Cys Lys Val Gln Ser Asn Arg Val Phe Cys Asp 
        355                 360                 365             
Thr Met Tyr Ser Leu Thr Leu Pro Ser Glu Val Asn Leu Cys Asn Val 
    370                 375                 380                 
Asp Ile Phe Asn Pro Lys Tyr Asp Cys Lys Ile Met Thr Ser Lys Thr 
385                 390                 395                 400 
Asp Val Ser Ser Ser Val Ile Thr Ser Leu Gly Ala Ile Val Ser Cys 
                405                 410                 415     
Tyr Gly Lys Thr Lys Cys Thr Ala Ser Asn Lys Asn Arg Gly Ile Ile 
            420                 425                 430         
Lys Thr Phe Ser Asn Gly Cys Asp Tyr Val Ser Asn Lys Gly Val Asp 
        435                 440                 445             
Thr Val Ser Val Gly Asn Thr Leu Tyr Tyr Val Asn Lys Gln Glu Gly 
    450                 455                 460                 
Lys Ser Leu Tyr Val Lys Gly Glu Pro Ile Ile Asn Phe Tyr Asp Pro 
465                 470                 475                 480 
Leu Val Phe Pro Ser Asp Glu Phe Asp Ala Ser Ile Ser Gln Val Asn 
                485                 490                 495     
Glu Lys Ile Gln Gln Ser Leu Ala Phe Ile Arg Lys Ser Asp Glu Leu 
            500                 505                 510         
Leu His Asn Val Asn Ala Gly Lys Ser Thr Thr Asn Ile Met Ile Thr 
        515                 520                 525             
Thr Ile Ile Ile Val Ile Ile Val Ile Leu Leu Ser Leu Ile Ala Val 
    530                 535                 540                 
Gly Leu Leu Leu Tyr Cys Lys Ala Arg Ser Thr Pro Ile Thr Leu Ser 
545                 550                 555                 560 
Lys Asp Gln Leu Ser Gly Ile Asn Asn Ile Ala Phe Ser Asn 
                565                 570                 

<210> 14
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> hRSV F N500Q

<400> 14
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgaac     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatccag    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer for RSV A2 M gene

<400> 15
tcacgaaggc tccacataca                                                20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer for RSV A2 M Gene

<400> 16
gcagggtcat cgtctttttc                                                20


<210> 17
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116-120Q

<400> 17
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgcagta taccctgcag     360

aataccaaga agacaaatgt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 18
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116-126Q

<400> 18
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgcagta taccctgaac     360

aataccaaga agacacaggt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 19
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N120-126Q

<400> 19
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgaacta taccctgcag     360

aataccaaga agacacaggt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 20
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116-120-126Q

<400> 20
atggagctgc ctatcctgaa ggccaacgcc atcaccacaa tcctggccgc cgtgaccttc      60

tgctttgcca gctcccagaa tatcaccgag gagttctacc agtccacatg ttctgccgtg     120

agcaaaggat acctgagcgc cctgagaaca ggatggtata cctctgtgat cacaatcgag     180

ctgagcaaca tcaagaagaa caagtgcaat ggcaccgacg ccaaggtgaa gctgatgaag     240

caggagctgg ataagtacaa gaatgccgtg accgagctgc agctgctgat gcagtccaca     300

ccagccgcca acaatagagc aagaagagag ctgccacggt tcatgcagta taccctgcag     360

aataccaaga agacacaggt gaccctgagc aagaagagga agaggcgctt cctgggcttt     420

ctgctgggag tgggatccgc cattgcatct ggcatcgccg tgtccaaggt cctgcacctg     480

gagggcgagg tgaacaagat caagagcgcc ctgctgtcca ccaacaaggc cgtggtgtct     540

ctgagcaatg gcgtgtctgt gctgacaagc agggtgctgg acctgaagaa ttacatcgat     600

aagcagctgc tgcctatcgt gaacaagcag tcctgtcgca tctctaatat cgagacagtg     660

atcgagttcc agcagaagaa caataggctg ctggagatca cacgcgagtt ttctgtgaac     720

gccggcgtga ccacacccgt gagcacctac atgctgacaa atagcgagct gctgtccctg     780

atcaacgaca tgcctatcac caatgatcag aagaagctga tgtctaacaa tgtgcagatc     840

gtgcggcagc agtcctattc tatcatgagc atcatcaagg aggaggtgct ggcctacgtg     900

gtgcagctgc cactgtatgg cgtgatcgac accccctgct ggaagctgca cacaagcccc     960

ctgtgcacca caaacaccaa ggagggctct aatatctgcc tgacccggac agacagaggc    1020

tggtattgtg ataacgccgg cagcgtgtcc ttctttccac aggccgagaa gtgcaaggtg    1080

cagagcaata gggtgttctg tgacaccatg tactctctga cactgcctag cgaggtgaac    1140

ctgtgcaatg tggacatctt taacccaaag tacgattgta agatcatgac atctaagacc    1200

gacgtgagca gctccgtgat caccagcctg ggcgccatcg tgtcctgcta cggcaagaca    1260

aagtgtaccg cctccaacaa gaatcgcggc atcatcaaga cattctccaa cggctgcgac    1320

tacgtgagca ataagggcgt ggataccgtg tccgtgggca acacactgta ctatgtgaat    1380

aagcaggagg gcaagtctct gtacgtgaag ggcgagccaa tcatcaactt ctatgacccc    1440

ctggtgttcc ctagcgacga gtttgatgcc tctatcagcc aggtgaacga gaagatcaat    1500

cagagcctgg cctttatccg gaagtccgat gagctgctgc acaacgtgaa tgccggcaag    1560

tccaccacaa atatcatgat caccacaatc atcatcgtga tcatcgtgat cctgctgagc    1620

ctgatcgccg tgggcctgct gctgtactgt aaggccagat ccacacccat caccctgtcc    1680

aaggatcagc tgtctggcat caacaatatc gcctttagca actaa                    1725


<210> 21
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F WT - Recombinant Virus

<400> 21
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac     360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 22
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N27Q - Recombinant virus

<400> 22
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaca aatcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac     360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 23
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N70Q - Recombinant virus

<400> 23
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtcaa ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac     360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 24
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116Q - Recombinant virus

<400> 24
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgcaata tacactcaac     360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 25
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N120Q - Recombinant virus

<400> 25
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactccaa     360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 26
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N126Q - Recombinant virus

<400> 26
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac     360

aataccaaaa aaacccaagt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 27
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116-126Q - Recombinant virus

<400> 27
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgcaata tacactcaac     360

aataccaaaa aaacccaagt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 28
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116-126Q - Recombinant virus

<400> 28
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgcaata tacactcaac     360

aataccaaaa aaacccaagt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 29
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N120-126Q - Recombinant virus

<400> 29
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactccaa     360

aataccaaaa aaacccaagt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 30
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N116-120-126Q - Recombinant virus

<400> 30
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgcaata tacactccaa     360

aataccaaaa aaacccaagt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattaac    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


<210> 31
<211> 1725
<212> DNA
<213> Respiratory syncytial virus


<220> 
<223> RSV F N500Q - Recombinant virus

<400> 31
atggagttgc caatcctcaa agcaaatgca attaccacaa tcctcgctgc agtcacattt      60

tgctttgctt ctagtcaaaa catcactgaa gaattttatc aatcaacatg cagtgcagtt     120

agcaaaggct atcttagtgc tctaagaact ggttggtata ctagtgttat aactatagaa     180

ttaagtaata tcaagaaaaa taagtgtaat ggaacagatg ctaaggtaaa attgatgaaa     240

caagaattag ataaatataa aaatgctgta acagaattgc agttgctcat gcaaagcaca     300

ccagcagcaa acaatcgagc cagaagagaa ctaccaaggt ttatgaatta tacactcaac     360

aataccaaaa aaaccaatgt aacattaagc aagaaaagga aaagaagatt tcttggtttt     420

ttgttaggtg ttggatctgc aatcgccagt ggcattgctg tatctaaggt cctgcactta     480

gaaggagaag tgaacaagat caaaagtgct ctactatcca caaacaaggc cgtagtcagc     540

ttatcaaatg gagttagtgt cttaaccagc agagtgttag acctcaaaaa ctatatagat     600

aaacaattgt tacctattgt gaataagcaa agctgcagaa tatcaaatat agaaactgtg     660

atagagttcc aacaaaagaa caacagacta ctagagatta ccagggaatt tagtgttaat     720

gcaggtgtaa ctacacctgt aagcacttac atgttaacta atagtgaatt attgtcatta     780

atcaatgata tgcctataac aaatgatcag aaaaagttaa tgtccaacaa tgttcaaata     840

gttagacagc aaagttactc tatcatgtcc ataataaaag aggaagtctt agcatatgta     900

gtacaattac cactatatgg tgtgatagat acaccttgtt ggaaattaca cacatcccct     960

ctatgtacaa ccaacacaaa agaagggtca aacatctgtt taacaagaac tgacagagga    1020

tggtactgtg acaatgcagg atcagtatct ttcttcccac aagctgaaaa atgtaaagtt    1080

caatcgaatc gagtattttg tgacacaatg tacagtttaa cattaccaag tgaagtaaat    1140

ctctgcaatg ttgacatatt caatcccaaa tatgattgta aaattatgac ttcaaaaaca    1200

gatgtaagca gctccgttat cacatctcta ggagccattg tgtcatgcta tggcaaaact    1260

aaatgtacag catccaataa aaatcgtgga atcataaaga cattttctaa cgggtgtgat    1320

tatgtatcaa ataaaggggt ggacactgtg tctgtaggta acacattata ttatgtaaat    1380

aagcaagaag gcaaaagtct ctatgtaaaa ggtgaaccaa taataaattt ctatgaccca    1440

ttagtattcc cctctgatga atttgatgca tcaatatctc aagtcaatga gaagattcaa    1500

cagagtttag catttattcg taaatccgat gaattattac ataatgtaaa tgctggtaaa    1560

tcaaccacaa atatcatgat aactactata attatagtga ttatagtaat attgttatca    1620

ttaattgctg ttggactgct cctatactgt aaggccagaa gcacaccaat cacactaagc    1680

aaggatcaac tgagtggtat aaataatatt gcatttagta actga                    1725


