                         SEQUENCE LISTING

<110>  NLIFE THERAPEUTICS, S.L.
 
<120>  COMPOSITIONS AND METHODS FOR THE DELIVERY OF mRNA TO HEPATIC 
       CELLS

<130>  P14376EP00

<140>  EP17382649.6
<141>  2017-09-29

<160>  148   

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  1

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  2
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Nucleoplasmin bipartite NLS sequence

<400>  2

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  5
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  6
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  IBB domain from importin-alpha sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Any naturally occuring amino acid

<400>  6

Arg Met Arg Ile Xaa Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  7
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  Myoma T protein sequence

<400>  7

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>   Myoma T protein sequence

<400>  8

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  9

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  10
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  11
<211>  5
<212>  PRT
<213>  Influenza virus

<400>  11

Asp Arg Leu Arg Arg 
1               5   


<210>  12
<211>  7
<212>  PRT
<213>  Influenza virus

<400>  12

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  13
<211>  10
<212>  PRT
<213>  Hepatitus delta virus

<400>  13

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  14
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  14

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  15
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  16
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Arg Gly Val Pro 
1               5                   10                  15      


<210>  18
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide

<400>  18

Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys Lys Lys Arg Lys Val 
1               5                   10                  15      


Asp 
    


<210>  19
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic peptide

<400>  19

Arg Lys Lys Arg Arg Arg Glu Ser Arg Lys Lys Arg Arg Arg Glu Ser 
1               5                   10                  15      


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  20

Gly Arg Pro Arg Glu Ser Gly Lys Lys Arg Lys Arg Lys Arg Leu Lys 
1               5                   10                  15      


Pro 
    


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  21

Gly Lys Arg Lys Lys Lys Gly Lys Leu Gly Lys Lys Arg Asp Pro 
1               5                   10                  15  


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  22

Gly Lys Arg Lys Lys Lys Gly Lys Leu Gly Lys Lys Arg Pro Arg Ser 
1               5                   10                  15      


Arg 
    


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  23

Arg Lys Lys Arg Arg Arg Glu Ser Arg Arg Ala Arg Arg Ser Pro Arg 
1               5                   10                  15      


His Leu 
        


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  24

Ser Arg Arg Ala Arg Arg Ser Pro Arg Glu Ser Gly Lys Lys Arg Lys 
1               5                   10                  15      


Arg Lys Arg 
            


<210>  25
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  25

Val Lys Arg Gly Leu Lys Leu Arg His Val Arg Pro Arg Val Thr Arg 
1               5                   10                  15      


Met Asp Val 
            


<210>  26
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  26

Ser Arg Arg Ala Arg Arg Ser Pro Arg His Leu Gly Ser Gly 
1               5                   10                  


<210>  27
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  27

Leu Arg Arg Glu Arg Gln Ser Arg Leu Arg Arg Glu Arg Gln Ser Arg 
1               5                   10                  15      


<210>  28
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  28

Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Leu Arg Arg 
1               5                   10                  15      


Arg Glu Arg Gln Ser Arg 
            20          


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  29

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  30

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  31

Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
1               5                   10                  15      


Arg 
    


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  32

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  33

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  34

Asn Ala Lys Thr Arg Arg His Glu Arg Arg Arg Lys Leu Ala Ile Glu 
1               5                   10                  15      


Arg 
    


<210>  35
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  35

Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys Gln Ala 
1               5                   10                  15      


Gln Trp Lys Ala Ala Asn 
            20          


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  36

Thr Ala Lys Thr Arg Tyr Lys Ala Arg Arg Ala Glu Leu Ile Ala Glu 
1               5                   10                  15      


Arg Arg 
        


<210>  37
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  37

Thr Arg Arg Asn Lys Arg Asn Arg Ile Gln Glu Gln Leu Asn Arg Lys 
1               5                   10                  15      


<210>  38
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  38

Pro Arg Arg Arg Arg Ser Ser Ser Arg Pro Val Arg Arg Arg Arg Arg 
1               5                   10                  15      


Pro Arg Val Ser Arg Arg Arg Arg Arg Arg Gly Gly Arg Arg Arg Arg 
            20                  25                  30          


<210>  39
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  39

Arg Ile Lys Ala Glu Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser 
1               5                   10                  15      


Lys Ser Arg Lys Arg Lys Leu Glu Arg Ile Ala Arg 
            20                  25              


<210>  40
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  40

Lys Arg Arg Ile Arg Arg Glu Arg Asn Lys Met Ala Ala Ala Lys Ser 
1               5                   10                  15      


Arg Asn Arg Arg Arg Glu Leu Thr Asp Thr 
            20                  25      


<210>  41
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  41

Lys Arg Ala Arg Asn Thr Glu Ala Ala Arg Arg Ser Arg Ala Arg Lys 
1               5                   10                  15      


Leu Gln Arg Met Lys Gln 
            20          


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  42

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  43

Arg Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210>  44
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  44

Ser Lys Arg Thr Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu 
1               5                   10                  15      


Glu Lys Glu Phe His Phe Asn Arg Tyr Ile Thr Arg Arg Arg Arg Ile 
            20                  25                  30          


Asp Ile Ala Asn Ala Leu Ser Leu Ser Glu Arg Gln Ile Lys Ile Trp 
        35                  40                  45              


Phe Gln Asn Arg Arg Met Lys Ser Lys Lys Asp Arg 
    50                  55                  60  


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  45

Ser Gln Ile Lys Ile Trp Phe Gln Asn Lys Arg Ala Lys Ile Lys Lys 
1               5                   10                  15      


<210>  46
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  46

Arg Gln Val Thr Ile Trp Phe Gln Asn Arg Arg Val Lys Glu Lys Lys 
1               5                   10                  15      


<210>  47
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  47

Lys Gln Ile Asn Asn Trp Phe Ile Asn Gln Arg Lys Arg His Trp Lys 
1               5                   10                  15      


<210>  48
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  48

Arg His Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  49
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  49

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Lys Lys Lys Arg Lys Val 
            20              


<210>  50
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  50

Met Val Lys Ser Lys Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala 
1               5                   10                  15      


Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25                  30  


<210>  51
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  51

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  52

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  53
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  53

Arg Arg Ile Arg Pro Arg Pro Pro Arg Leu Pro Arg Pro Arg Pro Arg 
1               5                   10                  15      


Pro Leu Pro Phe Pro Arg Pro Gly 
            20                  


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  54

Val Asp Lys Gly Ser Tyr Leu Pro Arg Pro Thr Pro Pro Arg Pro Ile 
1               5                   10                  15      


Tyr Asn Arg Asn 
            20  


<210>  55
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  55

Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val Arg Gly Pro Pro 
1               5                   10                  15      


Val Ser Cys Ile Lys Arg 
            20          


<210>  56
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  56

Thr Arg Ser Ser Arg Ala Gly Leu Gln Trp Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  57
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  57

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  58
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  58

Gly Ile Gly Lys Trp Leu His Ser Ala Lys Lys Phe Gly Lys Ala Phe 
1               5                   10                  15      


Val Gly Glu Ile Met Asn Ser 
            20              


<210>  59
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  59

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu 
        35      


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  60

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  61

Tyr Lys Gln Cys His Lys Lys Gly Gly Lys Lys Gly Ser Gly 
1               5                   10                  


<210>  62
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  62

Ala Leu Trp Lys Thr Leu Leu Lys Lys Val Leu Lys Ala Pro Lys Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210>  63
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  63

His Ala Arg Ile Lys Pro Thr Phe Arg Arg Leu Lys Trp Lys Tyr Lys 
1               5                   10                  15      


Gly Lys Phe Trp 
            20  


<210>  64
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  64

Thr Lys Arg Arg Ile Thr Pro Lys Asp Val Ile Asp Val Arg Ser Val 
1               5                   10                  15      


Thr Thr Glu Ile Asn Thr 
            20          


<210>  65
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  65

Arg Gln Gly Ala Ala Arg Val Thr Ser Trp Leu Gly Arg Gln Leu Arg 
1               5                   10                  15      


Ile Ala Gly Lys Arg Leu Glu Gly Arg Ser Lys 
            20                  25          


<210>  66
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  66

Asn Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Gln Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Gln 
        


<210>  67
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  67

Arg His Ser Arg Ile Gly Ile Ile Gln Gln Arg Arg Thr Arg Asn Gly 
1               5                   10                  15      


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  68

Lys Leu Ile Lys Gly Arg Thr Pro Ile Lys Phe Gly Lys Ala Asp Cys 
1               5                   10                  15      


Asp Arg Pro Pro Lys His Ser Gln Asn Gly Met Gly Lys 
            20                  25                  


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  69

Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro 
1               5                   10          


<210>  70
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  70

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  71

Arg Arg Ile Pro Asn Arg Arg Pro Arg Arg 
1               5                   10  


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  72

Arg Leu Arg Trp Arg 
1               5   


<210>  73
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  73

Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  74
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  74

Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly 
1               5                   10                  15      


Pro Pro Arg Val Arg Val 
            20          


<210>  75
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  75

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  76
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  76

Leu Ser Thr Ala Ala Asp Met Gln Gly Val Val Thr Asp Gly Met Ala 
1               5                   10                  15      


Ser Gly 
        


<210>  77
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  77

Leu Ser Thr Ala Ala Asp Met Gln Gly Val Val Thr Asp Gly Met Ala 
1               5                   10                  15      


Ser Gly Leu Asp Lys Asp Tyr Leu Lys Pro Asp Asp 
            20                  25              


<210>  78
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  78

Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
1               5                   10                  15  


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  79

Val Pro Thr Leu Lys 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  80

Pro Met Leu Lys Glu 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  81

Val Pro Ala Leu Arg 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  82

Val Ser Ala Leu Lys 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  83

Ile Pro Ala Leu Lys 
1               5   


<210>  84
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  84

Pro Phe Val Tyr Leu Ile 
1               5       


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  85

Pro Ile Glu Val Cys Met Tyr Arg Glu Pro 
1               5                   10  


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  86

Arg Arg Arg Arg Arg Arg Arg Arg 
1               5               


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  87

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  88

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210>  89
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  89

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10          


<210>  90
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  90

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Arg Lys Val 
            20  


<210>  91
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  91

Gly Leu Ala Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  92
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  92

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  93
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Aib

<400>  93

Ala Gly Tyr Leu Leu Gly His Ile Asn Leu His His Leu Ala His Leu 
1               5                   10                  15      


Xaa His His Ile Leu 
            20      


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  94

Lys Leu Ala Leu Lys Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  95

Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   


<210>  96
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  96

Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Trp Arg Ala 
            20  


<210>  97
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  97

Leu Ile Arg Leu Trp Ser His Leu Ile His Ile Trp Phe Gln Asn Arg 
1               5                   10                  15      


Arg Leu Lys Trp Lys Lys Lys 
            20              


<210>  98
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  98

Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu His 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30  


<210>  99
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  99

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210>  100
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  100

Leu Lys Thr Leu Thr Glu Thr Leu Lys Glu Leu Thr Lys Thr Leu Thr 
1               5                   10                  15      


Glu Leu 
        


<210>  101
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  101

Gln Leu Ala Leu Gln Leu Ala Leu Gln Ala Leu Gln Ala Ala Leu Gln 
1               5                   10                  15      


Leu Ala 
        


<210>  102
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  102

Pro Pro Arg Pro Pro Arg Pro Pro Arg 
1               5                   


<210>  103
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  103

Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg 
1               5                   10          


<210>  104
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  104

Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg 
1               5                   10                  15  


<210>  105
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  105

Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro Pro Arg Pro 
1               5                   10                  15      


Pro Arg 
        


<210>  106
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  106

Pro Arg Arg Pro Arg Arg Pro Arg Arg 
1               5                   


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  107

Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg 
1               5                   10          


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  108

Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg 
1               5                   10                  15  


<210>  109
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  109

Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro Arg Arg Pro 
1               5                   10                  15      


Arg Arg 
        


<210>  110
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  110

Gly Pro Ser Gln Pro Thr Tyr Pro Gly Asp Asp Ala Pro Val Arg Asp 
1               5                   10                  15      


Leu Ile Arg Phe Tyr Arg Asp Leu Gln Arg Tyr Leu Asn Val Val Thr 
            20                  25                  30          


Arg His Arg Tyr 
        35      


<210>  111
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  111

Gly Pro Ser Gln Pro Thr Tyr Pro Gly Asp Asp Ala Pro Val Arg Asp 
1               5                   10                  15      


Leu Ile Arg Phe Tyr Arg Asp Leu Arg Arg Tyr Leu Asn Val Val Thr 
            20                  25                  30          


Arg His Arg Tyr 
        35      


<210>  112
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  112

Gly Pro Ser Gln Pro Thr Tyr Pro Gly Asp Asp Ala Pro Val Arg Asp 
1               5                   10                  15      


Leu Arg Arg Phe Tyr Arg Asp Leu Arg Arg Tyr Leu Asn Val Val Thr 
            20                  25                  30          


Arg His Arg Tyr 
        35      


<210>  113
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Proline-based mimic of leucine

<220>
<221>  Repeat
<222>  (2)..(4)
<223>  internal sequence that can be repeated n times, wherein n is a 
       whole number.

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Proline-based mimic of lysine or arginine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Proline-based mimic of leucine

<400>  113

Gly Xaa Xaa Xaa Xaa 
1               5   


<210>  114
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  114

Val Arg Leu Pro Pro Pro Val Arg Leu Pro Pro Pro Val Arg Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  115

Val Glu Leu Pro Pro Pro Val Glu Leu Pro Pro Pro Val Glu Leu Pro 
1               5                   10                  15      


Pro Pro 
        


<210>  116
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  116

Phe Lys Ile Tyr Asp Lys Lys Val Arg Thr Arg Val Val Lys His 
1               5                   10                  15  


<210>  117
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  117

Arg Ala Ser Lys Arg Asp Gly Ser Trp Val Lys Lys Leu His Arg Ile 
1               5                   10                  15      


Leu Glu 
        


<210>  118
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  118

Lys Gly Thr Tyr Lys Lys Lys Leu Met Arg Ile Pro Leu Lys Gly Thr 
1               5                   10                  15      


<210>  119
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  119

Leu Tyr Lys Lys Gly Pro Ala Lys Lys Gly Arg Pro Pro Leu Arg Gly 
1               5                   10                  15      


Trp Phe His 
            


<210>  120
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  120

His Ser Pro Ile Ile Pro Leu Gly Thr Arg Phe Val Cys His Gly Val 
1               5                   10                  15      


Thr 
    


<210>  121
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  121

Tyr Thr Ala Ile Ala Trp Val Lys Ala Phe Ile Arg Lys Leu Arg Lys 
1               5                   10                  15      


<210>  122
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  122

Ile Ala Trp Val Lys Ala Phe Ile Arg Lys Leu Arg Lys Gly Pro Leu 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  123

Arg Leu Ser Gly Met Asn Glu Val Leu Ser Phe Arg Trp Leu 
1               5                   10                  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  124

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  125
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  125

Val Thr Trp Thr Pro Gln Ala Trp Phe Gln Trp Val 
1               5                   10          


<210>  126
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  126

Gly Ser Pro Trp Gly Leu Gln His His Pro Pro Arg Thr 
1               5                   10              


<210>  127
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  127

Gly Pro Phe His Phe Tyr Gln Phe Leu Phe Pro Pro Val 
1               5                   10              


<210>  128
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  128

Thr Ser Pro Leu Asn Ile His Asn Gly Gln Lys Leu 
1               5                   10          


<210>  129
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  129

Cys Ala Tyr His Arg Leu Arg Arg Cys 
1               5                   


<210>  130
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  130

Arg Cys Gly Arg Ala Ser Arg Cys Arg Val Arg Trp Met Arg Arg Arg 
1               5                   10                  15      


Arg Ile 
        


<210>  131
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  131

Pro Tyr Ser Arg Pro His Val Gln Leu Trp Tyr Pro Asn Arg Glu Ser 
1               5                   10                  15      


Cys Arg Ser Leu Ile Arg Ser Leu Gly Pro 
            20                  25      


<210>  132
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  132

Pro Leu Ile Leu Leu Arg Leu Leu Arg Gly Gln Phe 
1               5                   10          


<210>  133
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  133

Pro Leu Ile Tyr Leu Arg Leu Leu Arg Gly Gln Phe 
1               5                   10          


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  134

Lys Leu Trp Met Arg Trp Tyr Ser Pro Thr Thr Arg Arg Tyr Gly 
1               5                   10                  15  


<210>  135
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  135

Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210>  136
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  136

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  137
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  137

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  138
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  138

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  139
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  139

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  140
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  140

Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu His 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala 
            20                  25                  30  


<210>  141
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  141

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210>  142
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  142

Gly Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu 
1               5                   10                  15      


Leu Leu Glu Ala 
            20  


<210>  143
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  143

Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210>  144
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  144

Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  145

Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10  


<210>  146
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  146

His Ser Trp Tyr Gly 
1               5   


<210>  147
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  147

Gly Leu Phe His Ala Ile Ala His Phe Ile His Gly Gly Trp His Gly 
1               5                   10                  15      


Leu Ile His Gly Trp Tyr Gly 
            20              


<210>  148
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  148

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


