               SEQUENCE LISTING



<110> Fechner Henry

      Hazini Ahmet

      Bruckner Vanessa



<120> Method for treating cancer with a Coxsackievirus B3 variant



<130> P14698US00 / FGP-001



<140> US15720850

<141> 2017-09-29



<160> 2



<170> BiSSAP 1.3.6



<210> 1

<211> 3294

<212> DNA

<213> artificial Sequence





<220> 

<223> VP4-VP2-VP3-VP1



<400> 1

ttaaaacagc ctgtgggttg atcccaccca cagggcccat tgggcgctag cactctggta       60



tcacggtacc tttgtgcgcc tgttttatac cccctccccc aactgtaact tagaagcaac      120



acacaccgat caacagtcag cgtggcacac cagccacgtt ttgatcaagc acttctgtta      180



ccccggactg agtatcaata gactgctcac gcggttgaag gagaaagcgt tcgttatccg      240



gccaactatt tcgaaaaacc tagtaacacc gtggaagttg cagagtgttt cgctcagcac      300



taccccagtg tagatcaggt cgatgagtca ccgcattccc cacgggcgac cgtggcggtg      360



gctgcgttgg cggcctgccc atggggaaac ccatgggacg ctctaataca gacatggtgc      420



gaagagtcta ttgagctagt tggtagtcct ccggcccctg aatgcggcta atcctaactg      480



cggagcacac accctcaagc cagagggcag tgtgtcgtaa cgggcaactc tgcagcggaa      540



ccgactactt tgggtgtccg tgtttcattt tattcctata ctggctgctt atggtgacaa      600



ttgagagatt gttaccatat agctattgga ttggccatcc ggtgaccaat agagctatta      660



tatatctctt tgttgggttt ataccactta gcttgaaaga ggttaaaaca ttacaattca      720



ttgttaagtt gaatacagca aaatgggagc tcaagtatca acgcaaaaga ctggggcaca      780



tgagaccggg ctgaatgcta gcggcaattc catcattcac tacacaaata ttaattatta      840



caaggatgcc gcatccaact cagccaatcg gcaggatttc actcaagacc cgggcaagtt      900



cacagaacca gtaaaagata tcatgattaa atcactacca gctctcaact cccccacagt      960



agaggagtgc ggatacagtg acagggtgag atcaatcaca ttaggtaact ccaccataac     1020



gactcaggaa tgcgccaacg tggtggtggg ctatggagta tggccagatt atctaaagga     1080



tagtgaggca acagcagagg accaaccgac ccaaccagac gttgccacat gtaggttcta     1140



tacccttgac tctgtgcaat ggcagaaaac ctcaccagga tggtggtgga agctgcccga     1200



tgctttgtcg aacttaggac tgtttgggca gaacatgcag taccactact taggccgaac     1260



tgggtatacc gtacatgtgc agtgcaatgc atctaagttc caccaaggat gcttgctagt     1320



agtgtgtgta ccggaagctg agatgggttg cgcaacgcta gacaacaccc catccagtgc     1380



agaattgctg gggggcgata gcgcaaaaga gtttgcggac aaaccggtcg catccgggtc     1440



caacaagttg gtacagaggg tggtgtataa tgcaggcatg ggggtgggtg ttggaaacct     1500



caccattttc ccccaccaat ggatcaacct acgcaccaat aatagtgcta caattgtgat     1560



gccatacacc aacagtgtac ctatggataa catgtttagg cataacaacg tcaccctaat     1620



ggttatccca tttgtaccgc tagattactg ccctgggtcc accacgtacg tcccaattac     1680



ggtcacgata gccccaatgt gtgccgagta caatgggtta cgtttagcag ggcaccaggg     1740



cttaccaacc atgaatactc cggggagctg tcaatttctg acatcagacg acttccaatc     1800



gccatccgcc atgccgcaat atgacgtcac accagagatg aggatacctg gtgaggtgaa     1860



aaacttgatg gaaatagctg aggttgactc agttgtccca gtccaaaatg ttggagagaa     1920



ggtcaactct atggaagcat accagatacc tgtgagatcc aatgaaggat ctggaacgca     1980



agtattcggc tttccactgc aaccagggta ctcgagtgtt tttagtcgga cgctcctagg     2040



agagatcttg aactattata cacattggtc aggcagcata aagcttacgt ttatgttctg     2100



tggttcggcc atggctactg gaaaattcct tttggcatac tcaccaccag gtgctggagc     2160



tcctacaaaa agggttgatg ccatgcttgg tactcatgta gtttgggacg tggggctaca     2220



atcaagttgc gtgctgtgta taccctggat aagccaaaca cactaccggt atgttgcttc     2280



agatgagtat accgcagggg gttttattac gtgctggtat caaacaaaca tagtggtccc     2340



agcggatgcc caaagctcct gttacatcat gtgttttgtg tcagcatgca atgacttctc     2400



tgtcaggcta ttgaaggata ctcctttcat ttcgcagcaa aacttttacc agggcccagt     2460



ggaagacgcg ataacagccg ctatagggag agttgcggat accgtgggta cagggccaac     2520



caactcagaa gctataccag cactcactgc tgctgagaca ggtcacacgt cacaagtagt     2580



gccgggtgac accatgcaga cacgccacgt taagaactac cattcaaggt ccgagtcaac     2640



catagagaac ttcctatgta ggtcagcatg cgtgtacttt acgaagtatg caaactcagg     2700



tgccaagcgg tatgctgaat gggcaataac accacgacaa gcagcacaac ttaggagaaa     2760



gctagaattc tttacctacg tccggttcga cctggagctg acgtttgtca taacaagtac     2820



tcaacagccc tcaaccacac agaaccaaga cgcacagatc ctaacacacc aaattatgta     2880



tgtaccacca ggtggacctg taccagagaa agttgattca tacgtgtggc aaacatctac     2940



gaatcccagt gtgttttgga ccgagggaaa cgccccgccg cgcatgtcca taccgttttt     3000



gagcattggc aacgcctatt caaatttcta tgacggatgg tctgaatttt ccaggaacgg     3060



agtttacggc atcaacacgc taaacaacat gggcacgcta tatgcaagac atgtcaactc     3120



tggaagcacg ggtccaataa aaagcaccat tagaatctac ttcaaaccga agcatgtcaa     3180



agcgtggata cctagaccac ctagactctg ccaatacgag aaggcaaaga acgtgaactt     3240



ccaacccagc ggagttacca ctactaggca aagcatcact acaatgacaa atac           3294





<210> 2

<211> 850

<212> PRT

<213> artificial Sequence





<220> 

<223> VP4-VP2-VP3-VP1



<400> 2

Met Gly Ala Gln Val Ser Thr Gln Lys Thr Gly Ala His Glu Thr Gly 

1               5                   10                  15      

Leu Asn Ala Ser Gly Asn Ser Ile Ile His Tyr Thr Asn Ile Asn Tyr 

            20                  25                  30          

Tyr Lys Asp Ala Ala Ser Asn Ser Ala Asn Arg Gln Asp Phe Thr Gln 

        35                  40                  45              

Asp Pro Gly Lys Phe Thr Glu Pro Val Lys Asp Ile Met Ile Lys Ser 

    50                  55                  60                  

Leu Pro Ala Leu Asn Ser Pro Thr Val Glu Glu Cys Gly Tyr Ser Asp 

65                  70                  75                  80  

Arg Val Arg Ser Ile Thr Leu Gly Asn Ser Thr Ile Thr Thr Gln Glu 

                85                  90                  95      

Cys Ala Asn Val Val Val Gly Tyr Gly Val Trp Pro Asp Tyr Leu Lys 

            100                 105                 110         

Asp Ser Glu Ala Thr Ala Glu Asp Gln Pro Thr Gln Pro Asp Val Ala 

        115                 120                 125             

Thr Cys Arg Phe Tyr Thr Leu Asp Ser Val Gln Trp Gln Lys Thr Ser 

    130                 135                 140                 

Pro Gly Trp Trp Trp Lys Leu Pro Asp Ala Leu Ser Asn Leu Gly Leu 

145                 150                 155                 160 

Phe Gly Gln Asn Met Gln Tyr His Tyr Leu Gly Arg Thr Gly Tyr Thr 

                165                 170                 175     

Val His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Cys Leu Leu 

            180                 185                 190         

Val Val Cys Val Pro Glu Ala Glu Met Gly Cys Ala Thr Leu Asp Asn 

        195                 200                 205             

Thr Pro Ser Ser Ala Glu Leu Leu Gly Gly Asp Ser Ala Lys Glu Phe 

    210                 215                 220                 

Ala Asp Lys Pro Val Ala Ser Gly Ser Asn Lys Leu Val Gln Arg Val 

225                 230                 235                 240 

Val Tyr Asn Ala Gly Met Gly Val Gly Val Gly Asn Leu Thr Ile Phe 

                245                 250                 255     

Pro His Gln Trp Ile Asn Leu Arg Thr Asn Asn Ser Ala Thr Ile Val 

            260                 265                 270         

Met Pro Tyr Thr Asn Ser Val Pro Met Asp Asn Met Phe Arg His Asn 

        275                 280                 285             

Asn Val Thr Leu Met Val Ile Pro Phe Val Pro Leu Asp Tyr Cys Pro 

    290                 295                 300                 

Gly Ser Thr Thr Tyr Val Pro Ile Thr Val Thr Ile Ala Pro Met Cys 

305                 310                 315                 320 

Ala Glu Tyr Asn Gly Leu Arg Leu Ala Gly His Gln Gly Leu Pro Thr 

                325                 330                 335     

Met Asn Thr Pro Gly Ser Cys Gln Phe Leu Thr Ser Asp Asp Phe Gln 

            340                 345                 350         

Ser Pro Ser Ala Met Pro Gln Tyr Asp Val Thr Pro Glu Met Arg Ile 

        355                 360                 365             

Pro Gly Glu Val Lys Asn Leu Met Glu Ile Ala Glu Val Asp Ser Val 

    370                 375                 380                 

Val Pro Val Gln Asn Val Gly Glu Lys Val Asn Ser Met Glu Ala Tyr 

385                 390                 395                 400 

Gln Ile Pro Val Arg Ser Asn Glu Gly Ser Gly Thr Gln Val Phe Gly 

                405                 410                 415     

Phe Pro Leu Gln Pro Gly Tyr Ser Ser Val Phe Ser Arg Thr Leu Leu 

            420                 425                 430         

Gly Glu Ile Leu Asn Tyr Tyr Thr His Trp Ser Gly Ser Ile Lys Leu 

        435                 440                 445             

Thr Phe Met Phe Cys Gly Ser Ala Met Ala Thr Gly Lys Phe Leu Leu 

    450                 455                 460                 

Ala Tyr Ser Pro Pro Gly Ala Gly Ala Pro Thr Lys Arg Val Asp Ala 

465                 470                 475                 480 

Met Leu Gly Thr His Val Val Trp Asp Val Gly Leu Gln Ser Ser Cys 

                485                 490                 495     

Val Leu Cys Ile Pro Trp Ile Ser Gln Thr His Tyr Arg Tyr Val Ala 

            500                 505                 510         

Ser Asp Glu Tyr Thr Ala Gly Gly Phe Ile Thr Cys Trp Tyr Gln Thr 

        515                 520                 525             

Asn Ile Val Val Pro Ala Asp Ala Gln Ser Ser Cys Tyr Ile Met Cys 

    530                 535                 540                 

Phe Val Ser Ala Cys Asn Asp Phe Ser Val Arg Leu Leu Lys Asp Thr 

545                 550                 555                 560 

Pro Phe Ile Ser Gln Gln Asn Phe Tyr Gln Gly Pro Val Glu Asp Ala 

                565                 570                 575     

Ile Thr Ala Ala Ile Gly Arg Val Ala Asp Thr Val Gly Thr Gly Pro 

            580                 585                 590         

Thr Asn Ser Glu Ala Ile Pro Ala Leu Thr Ala Ala Glu Thr Gly His 

        595                 600                 605             

Thr Ser Gln Val Val Pro Gly Asp Thr Met Gln Thr Arg His Val Lys 

    610                 615                 620                 

Asn Tyr His Ser Arg Ser Glu Ser Thr Ile Glu Asn Phe Leu Cys Arg 

625                 630                 635                 640 

Ser Ala Cys Val Tyr Phe Thr Lys Tyr Ala Asn Ser Gly Ala Lys Arg 

                645                 650                 655     

Tyr Ala Glu Trp Ala Ile Thr Pro Arg Gln Ala Ala Gln Leu Arg Arg 

            660                 665                 670         

Lys Leu Glu Phe Phe Thr Tyr Val Arg Phe Asp Leu Glu Leu Thr Phe 

        675                 680                 685             

Val Ile Thr Ser Thr Gln Gln Pro Ser Thr Thr Gln Asn Gln Asp Ala 

    690                 695                 700                 

Gln Ile Leu Thr His Gln Ile Met Tyr Val Pro Pro Gly Gly Pro Val 

705                 710                 715                 720 

Pro Glu Lys Val Asp Ser Tyr Val Trp Gln Thr Ser Thr Asn Pro Ser 

                725                 730                 735     

Val Phe Trp Thr Glu Gly Asn Ala Pro Pro Arg Met Ser Ile Pro Phe 

            740                 745                 750         

Leu Ser Ile Gly Asn Ala Tyr Ser Asn Phe Tyr Asp Gly Trp Ser Glu 

        755                 760                 765             

Phe Ser Arg Asn Gly Val Tyr Gly Ile Asn Thr Leu Asn Asn Met Gly 

    770                 775                 780                 

Thr Leu Tyr Ala Arg His Val Asn Ser Gly Ser Thr Gly Pro Ile Lys 

785                 790                 795                 800 

Ser Thr Ile Arg Ile Tyr Phe Lys Pro Lys His Val Lys Ala Trp Ile 

                805                 810                 815     

Pro Arg Pro Pro Arg Leu Cys Gln Tyr Glu Lys Ala Lys Asn Val Asn 

            820                 825                 830         

Phe Gln Pro Ser Gly Val Thr Thr Thr Arg Gln Ser Ile Thr Thr Met 

        835                 840                 845             

Thr Asn 

    850 



