                         SEQUENCE LISTING

<110>  Elasmogen Ltd
 
<120>  SPECIFIC BINDING MOLECULES

<130>  P111682wo

<150>  62/563948
<151>  2017-09-27

<150>  62/667126
<151>  2018-05-04

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1 CDR3

<400>  1

Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
1               5                   10      


<210>  2
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1 CDR3

<400>  2

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105     


<210>  3
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1

<400>  3

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Ala Ala Ala His His His 
            100                 105                 110         


His His His Gly Ala Ala Glu Ser Lys Leu Ile Ser Glu Glu Asp Leu 
        115                 120                 125             


<210>  4
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1

<400>  4
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaat                                                    318


<210>  5
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1 WITH HIS AND MYC TAGS

<400>  5
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgc ggccgcacat catcatcacc atcacggcgc cgcagaatca      360

aaactcatct cagaagagga tctg                                             384


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR C4 CDR3

<400>  6

Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val 
1               5                   10                  


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR C4

<400>  7

Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser 
1               5                   10                  15      


Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser Ser 
            20                  25                  30          


Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile 
        35                  40                  45              


Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys Ser 
    50                  55                  60                  


Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr 
65                  70                  75                  80  


Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser 
                85                  90                  95      


Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn 
            100                 105             


<210>  8
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR C4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  8

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Ala Ala Ala 
            100                 105                 110         


His His His His His His Gly Ala Ala Glu Ser Lys Leu Ile Ser Glu 
        115                 120                 125             


Glu Asp Leu 
    130     


<210>  9
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR C4

<400>  9
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag caactgtggg ttgtccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacaattaac      180

gaaggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agttaagctg gtggacccag aactggagat gctcaaattc cgatgtatac      300

ggaggtggca ctgtcgtgac tgtgaat                                          327


<210>  10
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1 WITH HIS AND MYC TAGS

<400>  10
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag caactgtggg ttgtccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacaattaac      180

gaaggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agttaagctg gtggacccag aactggagat gctcaaattc cgatgtatac      300

ggaggtggca ctgtcgtgac tgtgaatgcg gccgcacatc atcatcacca tcacggcgcc      360

gcagaatcaa aactcatctc agaagaggat ctg                                   393


<210>  11
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR B4 CDR3

<400>  11

Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met Ile Ser Gly Gly Thr 
1               5                   10                  15      


Ser Gly Pro Ile His Asp Val 
            20              


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR B4

<400>  12

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Ser 
            20                  25                  30          


Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met 
                85                  90                  95      


Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly Gly 
            100                 105                 110         


Thr Val Val Thr Val Asn 
        115             


<210>  13
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR B4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  13

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Ser 
            20                  25                  30          


Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met 
                85                  90                  95      


Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly Gly 
            100                 105                 110         


Thr Val Val Thr Val Asn Ala Ala Ala His His His His His His Gly 
        115                 120                 125             


Ala Ala Glu Ser Lys Leu Ile Ser Glu Glu Asp Leu 
    130                 135                 140 


<210>  14
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR B4

<400>  14
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag taactgtgca ttgtccagca tgtactggta tcgcaaaaaa      120

tctggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca aggtatatat accttgcatc gatgaactgg tatatatgat cagtgggggt      300

acctctggcc cgattcatga tgtatacgga ggtggcactg tcgtgactgt gaat            354


<210>  15
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15

<400>  15
gctaggctct agaaataatt ttgtttaact ttaagaagga gatataccat ggctcgagtg       60

gaccaaacac c                                                            71


<210>  16
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  16

<400>  16
cgcgccggat ccgccacctc cgctaccgcc acctccgcta ccgccacctc cgctaccgcc       60

acctccattc acagtcacga cagtgcc                                           87


<210>  17
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  17

<400>  17
ggtggcggat ccggcgcgca ctccgctcga gtggaccaaa caccgc                      46


<210>  18
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  18

<400>  18
gtccggaatt ctcacagatc ctcttctgag atgagttttt gttctgcggc ccc              53


<210>  19
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  19

<400>  19
aattcccctc tagaaggcgc gcactccgct cgagtggacc aaacaccg                    48


<210>  20
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR B4 WITH HIS AND MYC TAGS

<400>  20
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag taactgtgca ttgtccagca tgtactggta tcgcaaaaaa      120

tctggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca aggtatatat accttgcatc gatgaactgg tatatatgat cagtgggggt      300

acctctggcc cgattcatga tgtatacgga ggtggcactg tcgtgactgt gaatgcggcc      360

gcacatcatc atcaccatca cggcgccgca gaatcaaaac tcatctcaga agaggatctg      420


<210>  21
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER D1-D1 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  21

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro 
        115                 120                 125             


Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val 
    130                 135                 140                 


Leu Arg Asp Ser His Cys Ala Thr Ser Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr 
                165                 170                 175     


Val Glu Thr Val Asn Ser Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn 
            180                 185                 190         


Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Ala Ser Glu Cys 
        195                 200                 205             


Gln Tyr Gly Leu Ala Glu Tyr Asp Val Tyr Gly Gly Gly Thr Val Val 
    210                 215                 220                 


Thr Val Asn Ala Ala Ala His His His His His His Gly Ala Ala Glu 
225                 230                 235                 240 


Ser Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 


<210>  22
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER D1-D1 WITH HIS AND MYC TAGS

<400>  22
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcggt agcggaggtg gtggcggatc cggcgcgcac      360

tccgctcgag tggaccaaac accgcaaaca ataacaaagg agacgggcga atcactgacc      420

atcaactgtg tcctacgaga tagccactgt gcaacctcca gcacgtactg gtatcgcaaa      480

aaatcgggct caacaaacga ggagagcata tcgaaaggtg gacgatatgt tgaaacagtt      540

aacagcggat caaagtcctt ttctttgaga attaatgatc taacagttga agacagtggc      600

acgtatcgat gcgcttccga gtgccaatat ggactggcag aatatgatgt atacggaggt      660

ggcactgtcg tgactgtgaa tgcggccgca catcatcatc accatcacgg ggccgcagaa      720

caaaaactca tctcagaaga ggatctg                                          747


<210>  23
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER C4-C4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  23

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp 
        115                 120                 125             


Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile 
    130                 135                 140                 


Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp 
145                 150                 155                 160 


Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly 
                165                 170                 175     


Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu 
            180                 185                 190         


Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys 
        195                 200                 205             


Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr 
    210                 215                 220                 


Gly Gly Gly Thr Val Val Thr Val Asn Ala Ala Ala His His His His 
225                 230                 235                 240 


His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250                 255 


<210>  24
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER C4-C4 WITH HIS AND MYC TAGS

<400>  24
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag caactgtggg ttgtccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacaattaac      180

gaaggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agttaagctg gtggacccag aactggagat gctcaaattc cgatgtatac      300

ggaggtggca ctgtcgtgac tgtgaacgga ggtggcggta gcggaggtgg tggcggatcc      360

ggcgcgcact ccgctcgagt ggaccaaaca ccgcaaacaa taacaaagga gacgggcgaa      420

tcactgacca tcaactgtgt cctacgagat agcaactgtg ggttgtccag cacgtactgg      480

tatcgcaaaa aatcgggctc aacaaacgag gagagcatat cgaaaggtgg acgatatgtt      540

gaaacaatta acgaaggatc aaagtccttt tctttgagaa ttaatgatct aacagttgaa      600

gacagtggca cgtatcgatg caagttaagc tggtggaccc agaactggag atgctcaaat      660

tccgatgtat acggaggtgg cactgtcgtg actgtgaacg cggccgcaca tcatcatcac      720

catcacgggg ccgcagaaca aaaactcatc tcagaagagg atctg                      765


<210>  25
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER B4-B4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  25

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Ser 
            20                  25                  30          


Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met 
                85                  90                  95      


Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly Gly 
            100                 105                 110         


Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr 
    130                 135                 140                 


Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser 
145                 150                 155                 160 


Asn Cys Ala Leu Ser Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser 
                165                 170                 175     


Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val 
            180                 185                 190         


Asn Ser Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val 
        195                 200                 205             


Glu Asp Ser Gly Thr Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp 
    210                 215                 220                 


Glu Leu Val Tyr Met Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp 
225                 230                 235                 240 


Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Ala Ala Ala His His 
                245                 250                 255     


His His His His Gly Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp 
            260                 265                 270         


Leu 
    


<210>  26
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER B4-B4 WITH HIS AND MYC TAGS

<400>  26
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag taactgtgca ttgtccagca tgtactggta tcgcaaaaaa      120

tctggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca aggtatatat accttgcatc gatgaactgg tatatatgat cagtgggggt      300

acctctggcc cgattcatga tgtatacgga ggtggcactg tcgtgactgt gaatggaggt      360

ggcggtagcg gaggtggtgg cggatccggc gcgcactccg ctcgagtgga ccaaacaccg      420

caaacaataa caaaggagac gggcgaatca ctgaccatca actgtgtcct acgagatagt      480

aactgtgcat tgtccagcat gtactggtat cgcaaaaaat ctggctcaac aaacgaggag      540

agcatatcga aaggtggacg atatgttgaa acagttaaca gcggatcaaa gtccttttct      600

ttgagaatta atgatctaac agttgaagac agtggcacgt atcgatgcaa ggtatatata      660

ccttgcatcg atgaactggt atatatgatc agtgggggta cctctggccc gattcatgat      720

gtatacggag gtggcactgt cgtgactgtg aatgcggccg cacatcatca tcaccatcac      780

ggggccgcag aacaaaaact catctcagaa gaggatctg                             819


<210>  27
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER D1-C4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  27

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro 
        115                 120                 125             


Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val 
    130                 135                 140                 


Leu Arg Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr 
                165                 170                 175     


Val Glu Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn 
            180                 185                 190         


Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp 
        195                 200                 205             


Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly 
    210                 215                 220                 


Thr Val Val Thr Val Asn Ala Ala Ala His His His His His His Gly 
225                 230                 235                 240 


Ala Ala Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                245                 250         


<210>  28
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER D1-C4 WITH HIS AND MYC TAGS

<400>  28
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcggt agcggaggtg gtggcggatc cggcgcgcac      360

tccgctcgag tggaccaaac accgcaaaca ataacaaagg agacgggcga atcactgacc      420

atcaactgtg tcctacgaga tagcaactgt gggttgtcca gcacgtactg gtatcgcaaa      480

aaatcgggct caacaaacga ggagagcata tcgaaaggtg gacgatatgt tgaaacaatt      540

aacgaaggat caaagtcctt ttctttgaga attaatgatc taacagttga agacagtggc      600

acgtatcgat gcaagttaag ctggtggacc cagaactgga gatgctcaaa ttccgatgta      660

tacggaggtg gcactgtcgt gactgtgaac gcggccgcac atcatcatca ccatcacggg      720

gccgcagaac aaaaactcat ctcagaagag gatctg                                756


<210>  29
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER D1-B4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  29

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Pro Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro 
        115                 120                 125             


Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val 
    130                 135                 140                 


Leu Arg Asp Ser Asn Cys Ala Leu Ser Ser Met Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr 
                165                 170                 175     


Val Glu Thr Val Asn Ser Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn 
            180                 185                 190         


Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Val Tyr Ile 
        195                 200                 205             


Pro Cys Ile Asp Glu Leu Val Tyr Met Ile Ser Gly Gly Thr Ser Gly 
    210                 215                 220                 


Pro Ile His Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Ala 
225                 230                 235                 240 


Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile 
                245                 250                 255     


Ser Glu Glu Asp Leu 
            260     


<210>  30
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODIGN FOR THE TNF VNAR DIMER D1-B4 
       NUCLEOTIDE SEQUENCE WITH HIS AND MYC TAGS

<400>  30
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcggt agcggaggtg gtggcggatc cggcgcgcac      360

tccgctcgag tggaccaaac accgcaaaca ataacaaagg agacgggcga atcactgacc      420

atcaactgtg tcctacgaga tagtaactgt gcattgtcca gcatgtactg gtatcgcaaa      480

aaatctggct caacaaacga ggagagcata tcgaaaggtg gacgatatgt tgaaacagtt      540

aacagcggat caaagtcctt ttctttgaga attaatgatc taacagttga agacagtggc      600

acgtatcgat gcaaggtata tataccttgc atcgatgaac tggtatatat gatcagtggg      660

ggtacctctg gcccgattca tgatgtatac ggaggtggca ctgtcgtgac tgtgaatgcg      720

gccgcacatc atcatcacca tcacggggcc gcagaacaaa aactcatctc agaagaggat      780

ctg                                                                    783


<210>  31
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER B4-D1 AMINO ACID SEQUENCE

<400>  31

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Ser 
            20                  25                  30          


Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met 
                85                  90                  95      


Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly Gly 
            100                 105                 110         


Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr 
    130                 135                 140                 


Lys Glu Thr Gly Glu Ser Leu Pro Ile Asn Cys Val Leu Arg Asp Ser 
145                 150                 155                 160 


His Cys Ala Thr Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser 
                165                 170                 175     


Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val 
            180                 185                 190         


Asn Ser Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val 
        195                 200                 205             


Glu Asp Ser Gly Thr Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu 
    210                 215                 220                 


Ala Glu Tyr Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Ala 
225                 230                 235                 240 


Ala Ala His His His His His His Gly Ala Ala Glu Gln Lys Leu Ile 
                245                 250                 255     


Ser Glu Glu Asp Leu 
            260     


<210>  32
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER B4-D1 NUCLEOTIDE SEQUENCE

<400>  32
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag taactgtgca ttgtccagca tgtactggta tcgcaaaaaa      120

tctggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca aggtatatat accttgcatc gatgaactgg tatatatgat cagtgggggt      300

acctctggcc cgattcatga tgtatacgga ggtggcactg tcgtgactgt gaatggaggt      360

ggcggtagcg gaggtggtgg cggatccggc gcgcactccg ctcgagtgga ccaaacaccg      420

caaacaataa caaaggagac gggcgaatca ctgaccatca actgtgtcct acgagatagc      480

cactgtgcaa cctccagcac gtactggtat cgcaaaaaat cgggctcaac aaacgaggag      540

agcatatcga aaggtggacg atatgttgaa acagttaaca gcggatcaaa gtccttttct      600

ttgagaatta atgatctaac agttgaagac agtggcacgt atcgatgcgc ttccgagtgc      660

caatatggac tggcagaata tgatgtatac ggaggtggca ctgtcgtgac tgtgaatgcg      720

gccgcacatc atcatcacca tcacggggcc gcagaacaaa aactcatctc agaagaggat      780

ctg                                                                    783


<210>  33
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER C4-B4 AMINO ACID SEQUENCE

<400>  33

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp 
        115                 120                 125             


Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile 
    130                 135                 140                 


Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Ser Ser Met Tyr Trp 
145                 150                 155                 160 


Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly 
                165                 170                 175     


Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys Ser Phe Ser Leu 
            180                 185                 190         


Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys 
        195                 200                 205             


Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met Ile Ser Gly Gly 
    210                 215                 220                 


Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly Gly Thr Val Val Thr 
225                 230                 235                 240 


Val Asn Ala Ala Ala His His His His His His Gly Ala Ala Glu Gln 
                245                 250                 255     


Lys Leu Ile Ser Glu Glu Asp 
            260             


<210>  34
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER C4-B4 NUCLEOTIDE SEQUENCE

<400>  34
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag caactgtggg ttgtccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacaattaac      180

gaaggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca agttaagctg gtggacccag aactggagat gctcaaattc cgatgtatac      300

ggaggtggca ctgtcgtgac tgtgaacgga ggtggcggta gcggaggtgg tggcggatcc      360

ggcgcgcact ccgctcgagt ggaccaaaca ccgcaaacaa taacaaagga gacgggcgaa      420

tcactgacca tcaactgtgt cctacgagat agtaactgtg cattgtccag catgtactgg      480

tatcgcaaaa aatctggctc aacaaacgag gagagcatat cgaaaggtgg acgatatgtt      540

gaaacagtta acagcggatc aaagtccttt tctttgagaa ttaatgatct aacagttgaa      600

gacagtggca cgtatcgatg caaggtatat ataccttgca tcgatgaact ggtatatatg      660

atcagtgggg gtacctctgg cccgattcat gatgtatacg gaggtggcac tgtcgtgact      720

gtgaatgcgg ccgcacatca tcatcaccat cacggggccg cagaacaaaa actcatctca      780

gaagaggatc tg                                                          792


<210>  35
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER B4-C4 AMINO ACID SEQUENCE

<400>  35

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu Ser 
            20                  25                  30          


Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr Met 
                85                  90                  95      


Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly Gly 
            100                 105                 110         


Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr 
    130                 135                 140                 


Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser 
145                 150                 155                 160 


Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser 
                165                 170                 175     


Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile 
            180                 185                 190         


Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val 
        195                 200                 205             


Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn 
    210                 215                 220                 


Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr 
225                 230                 235                 240 


Val Asn Ala Ala Ala His His His His His His Gly Ala Ala Glu Gln 
                245                 250                 255     


Lys Leu Ile Ser Glu Glu Asp 
            260             


<210>  36
<211>  792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TNF VNAR DIMER B4-C4 NUCLEOTIDE SEQUENCE

<400>  36
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag taactgtgca ttgtccagca tgtactggta tcgcaaaaaa      120

tctggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgca aggtatatat accttgcatc gatgaactgg tatatatgat cagtgggggt      300

acctctggcc cgattcatga tgtatacgga ggtggcactg tcgtgactgt gaatggaggt      360

ggcggtagcg gaggtggtgg cggatccggc gcgcactccg ctcgagtgga ccaaacaccg      420

caaacaataa caaaggagac gggcgaatca ctgaccatca actgtgtcct acgagatagc      480

aactgtgggt tgtccagcac gtactggtat cgcaaaaaat cgggctcaac aaacgaggag      540

agcatatcga aaggtggacg atatgttgaa acaattaacg aaggatcaaa gtccttttct      600

ttgagaatta atgatctaac agttgaagac agtggcacgt atcgatgcaa gttaagctgg      660

tggacccaga actggagatg ctcaaattcc gatgtatacg gaggtggcac tgtcgtgact      720

gtgaacgcgg ccgcacatca tcatcaccat cacggggccg cagaacaaaa actcatctca      780

gaagaggatc tg                                                          792


<210>  37
<211>  383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1-BA11-C4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  37

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala 
        115                 120                 125             


His Ser Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro 
145                 150                 155                 160 


Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys 
                165                 170                 175     


Glu Gln Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly 
            180                 185                 190         


Thr Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Arg Ala Met Ser Thr Asn Ile Trp Thr Gly Asp 
    210                 215                 220                 


Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala His 
                245                 250                 255     


Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly 
            260                 265                 270         


Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu 
        275                 280                 285             


Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu 
    290                 295                 300                 


Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser 
305                 310                 315                 320 


Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly 
                325                 330                 335     


Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser 
            340                 345                 350         


Asn Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn His His 
        355                 360                 365             


His His His His His Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    370                 375                 380             


<210>  38
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE TNF VNAR D1-BA11-C4 WITH HIS 
       AND MYC TAGS

<400>  38
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcgga tccgggggtg gcggtagcgg aggtggcggt      360

agcggaggtg gcggtagtgg agctcattca acaagagtgg accaaagtcc aagctctctg      420

tccgccagtg tgggcgaccg cgtgaccatc acctgcgtcc tgactgatac cagctatcct      480

ctgtacagca catactggta tcggaagaat cccggttcca gcaacaagga gcagatttcc      540

atctccggcc gctatagtga atcagtcaac aagggcacta agtcctttac cctgacaatc      600

agttccctgc agcccgagga ctccgccacc tattactgca gagctatgag tacaaatatc      660

tggaccgggg acggagctgg taccaaggtg gagatcaagg gaggtggcgg ttccggaggt      720

ggcggtagcg gaggtggcgg tagcggaggt ggcggtagcg gggcccattc tgctcgagtg      780

gaccaaacac cgcaaacaat aacaaaggag acgggcgaat cactgaccat caactgtgtc      840

ctacgagata gcaactgtgg gttgtccagc acgtactggt atcgcaaaaa atcgggctca      900

acaaacgagg agagcatatc gaaaggtgga cgatatgttg aaacaattaa cgaaggatca      960

aagtcctttt ctttgagaat taatgatcta acagttgaag acagtggcac gtatcgatgc     1020

aagttaagct ggtggaccca gaactggaga tgctcaaatt ccgatgtata cggaggtggc     1080

actgtcgtga ctgtgaatca tcaccatcac catcaccatg aacaaaaact catctcagaa     1140

gaggatctg                                                             1149


<210>  39
<211>  380
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1-BA11-D1 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  39

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala 
        115                 120                 125             


His Ser Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro 
145                 150                 155                 160 


Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys 
                165                 170                 175     


Glu Gln Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly 
            180                 185                 190         


Thr Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Arg Ala Met Ser Thr Asn Ile Trp Thr Gly Asp 
    210                 215                 220                 


Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala His 
                245                 250                 255     


Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly 
            260                 265                 270         


Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr 
        275                 280                 285             


Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu 
    290                 295                 300                 


Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser 
305                 310                 315                 320 


Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly 
                325                 330                 335     


Thr Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp 
            340                 345                 350         


Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn His His His His His 
        355                 360                 365             


His His Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
    370                 375                 380 


<210>  40
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE TNF VNAR D1-BA11-D1 WITH HIS 
       AND MYC TAGS

<400>  40
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcgga tccgggggtg gcggtagcgg aggtggcggt      360

agcggaggtg gcggtagtgg agctcattca acaagagtgg accaaagtcc aagctctctg      420

tccgccagtg tgggcgaccg cgtgaccatc acctgcgtcc tgactgatac cagctatcct      480

ctgtacagca catactggta tcggaagaat cccggttcca gcaacaagga gcagatttcc      540

atctccggcc gctatagtga atcagtcaac aagggcacta agtcctttac cctgacaatc      600

agttccctgc agcccgagga ctccgccacc tattactgca gagctatgag tacaaatatc      660

tggaccgggg acggagctgg taccaaggtg gagatcaagg gaggtggcgg ttccggaggt      720

ggcggtagcg gaggtggcgg tagcggaggt ggcggtagcg gggcccattc tgctcgagtg      780

gaccaaacac cgcaaacaat aacaaaggag acgggcgaat cactgaccat caactgtgtc      840

ctacgagata gccactgtgc aacctccagc acgtactggt atcgcaaaaa atcgggctca      900

acaaacgagg agagcatatc gaaaggtgga cgatatgttg aaacagttaa cagcggatca      960

aagtcctttt ctttgagaat taatgatcta acagttgaag acagtggcac gtatcgatgc     1020

gcttccgagt gccaatatgg actggcagaa tatgatgtat acggaggtgg cactgtcgtg     1080

actgtgaatc atcaccatca ccatcaccat gaacaaaaac tcatctcaga agaggatctg     1140


<210>  41
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF VNAR D1-BA11-B4 AMINO ACID SEQUENCE WITH HIS AND MYC TAGS

<400>  41

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala 
        115                 120                 125             


His Ser Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro 
145                 150                 155                 160 


Leu Tyr Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys 
                165                 170                 175     


Glu Gln Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly 
            180                 185                 190         


Thr Lys Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser 
        195                 200                 205             


Ala Thr Tyr Tyr Cys Arg Ala Met Ser Thr Asn Ile Trp Thr Gly Asp 
    210                 215                 220                 


Gly Ala Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ala His 
                245                 250                 255     


Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly 
            260                 265                 270         


Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Ala Leu 
        275                 280                 285             


Ser Ser Met Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu 
    290                 295                 300                 


Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser 
305                 310                 315                 320 


Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly 
                325                 330                 335     


Thr Tyr Arg Cys Lys Val Tyr Ile Pro Cys Ile Asp Glu Leu Val Tyr 
            340                 345                 350         


Met Ile Ser Gly Gly Thr Ser Gly Pro Ile His Asp Val Tyr Gly Gly 
        355                 360                 365             


Gly Thr Val Val Thr Val Asn His His His His His His His Glu Gln 
    370                 375                 380                 


Lys Leu Ile Ser Glu Glu Asp Leu 
385                 390         


<210>  42
<211>  1176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE TNF VNAR D1-BA11-B4 WITH HIS 
       AND MYC TAGS

<400>  42
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcgga tccgggggtg gcggtagcgg aggtggcggt      360

agcggaggtg gcggtagtgg agctcattca acaagagtgg accaaagtcc aagctctctg      420

tccgccagtg tgggcgaccg cgtgaccatc acctgcgtcc tgactgatac cagctatcct      480

ctgtacagca catactggta tcggaagaat cccggttcca gcaacaagga gcagatttcc      540

atctccggcc gctatagtga atcagtcaac aagggcacta agtcctttac cctgacaatc      600

agttccctgc agcccgagga ctccgccacc tattactgca gagctatgag tacaaatatc      660

tggaccgggg acggagctgg taccaaggtg gagatcaagg gaggtggcgg ttccggaggt      720

ggcggtagcg gaggtggcgg tagcggaggt ggcggtagcg gggcccattc tgctcgagtg      780

gaccaaacac cgcaaacaat aacaaaggag acgggcgaat cactgaccat caactgtgtc      840

ctacgagata gtaactgtgc attgtccagc atgtactggt atcgcaaaaa atctggctca      900

acaaacgagg agagcatatc gaaaggtgga cgatatgttg aaacagttaa cagcggatca      960

aagtcctttt ctttgagaat taatgatcta acagttgaag acagtggcac gtatcgatgc     1020

aaggtatata taccttgcat cgatgaactg gtatatatga tcagtggggg tacctctggc     1080

ccgattcatg atgtatacgg aggtggcact gtcgtgactg tgaatcatca ccatcaccat     1140

caccatgaac aaaaactcat ctcagaagag gatctg                               1176


<210>  43
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR 2D4-Fc-2D4 AMINO ACID SEQUENCE

<400>  43

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Asp Tyr Gly Leu Phe 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Phe Thr Trp Pro Trp Glu Trp Pro Asp Arg Trp 
                85                  90                  95      


Phe Arg Pro Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ala Asp Gln Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys Thr Ala Ala Ala Ala Thr Ala Ala Ala Ala Thr Ala Ala Ala 
        355                 360                 365             


Ala Thr Ala Ala Ala Ala Thr Arg Val Asp Gln Thr Pro Arg Thr Ala 
    370                 375                 380                 


Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Thr Asp 
385                 390                 395                 400 


Thr Asp Tyr Gly Leu Phe Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly 
                405                 410                 415     


Thr Thr Asp Trp Glu Arg Met Ser Ile Gly Gly Arg Tyr Val Glu Ser 
            420                 425                 430         


Val Asn Lys Gly Ala Lys Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr 
        435                 440                 445             


Val Ala Asp Ser Ala Thr Tyr Tyr Cys Lys Ala Phe Thr Trp Pro Trp 
    450                 455                 460                 


Glu Trp Pro Asp Arg Trp Phe Arg Pro Trp Tyr Asp Gly Ala Gly Thr 
465                 470                 475                 480 


Val Leu Thr Val Asn 
                485 


<210>  44
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR 2D4-Fc-2D4

<400>  44
acacgtgttg accagacacc gcgtaccgca accaaagaaa ccggtgaaag cctgaccatt       60

aattgtgttc tgaccgatac cgattatggt ttgttctcca ccagctggtt tcgtaaaaat      120

ccgggtacaa ccgattggga acgtatgagc attggtggtc gttatgttga aagcgtgaat      180

aaaggtgcca aaagctttag cctgcgcatt aaagatctga ccgttgcaga tagcgcaacc      240

tattactgta aagcattcac ttggccgtgg gaatggccgg accgttggtt ccgtccgtgg      300

tatgatggtg caggcaccgt tctgaccgtt aatggcggtg gtggttctgg tggtggtgct      360

gatcaggagc ccaaatcttc tgacaaaact cacacatgtc caccgtgccc agcacctgaa      420

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      480

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      540

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      600

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      660

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      720

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      780

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      840

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      900

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac      960

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1020

aaccactaca cgcagaagag cctctccctg tccccgggta aaaccgccgc cgccgccacc     1080

gccgccgccg ccaccgccgc cgccgccacc gccgcggccg ccacacgtgt tgatcagaca     1140

ccgcgtaccg caaccaaaga aaccggtgaa agcctgacca ttaattgtgt tctgaccgat     1200

accgattatg gtttgttctc caccagctgg tttcgtaaaa atccgggtac aaccgattgg     1260

gaacgtatga gcattggtgg tcgttatgtt gaaagcgtga ataaaggtgc caaaagcttt     1320

agcctgcgca ttaaagatct gaccgttgca gatagcgcaa cctattactg taaagcattc     1380

acttggccgt gggaatggcc ggaccgttgg ttccgtccgt ggtatgatgg tgcaggcacc     1440

gttctgaccg ttaat                                                      1455


<210>  45
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR 2D4-Fc-CC3 AMINO ACID SEQUENCE

<400>  45

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Asp Tyr Gly Leu Phe 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Phe Thr Trp Pro Trp Glu Trp Pro Asp Arg Trp 
                85                  90                  95      


Phe Arg Pro Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ala Asp Gln Glu Pro Lys Ser Ser Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys Thr Ala Ala Ala Ala Thr Ala Ala Ala Ala Thr Ala Ala Ala 
        355                 360                 365             


Ala Thr Ala Ala Ala Ala Thr Arg Val Asp Gln Thr Pro Arg Thr Ala 
    370                 375                 380                 


Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Thr Asp 
385                 390                 395                 400 


Thr Glu Tyr Gly Leu Phe Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly 
                405                 410                 415     


Thr Thr Asp Trp Glu Arg Met Ser Ile Gly Gly Arg Tyr Val Glu Ser 
            420                 425                 430         


Val Asn Lys Gly Ala Lys Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr 
        435                 440                 445             


Val Ala Asp Ser Ala Thr Tyr Tyr Cys Lys Ala Leu Gly Trp Trp Pro 
    450                 455                 460                 


Pro Ala Phe Pro His Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val 
465                 470                 475                 480 


Asn 
    


<210>  46
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR 2D4-Fc-CC3

<400>  46
acacgtgttg accagacacc gcgtaccgca accaaagaaa ccggtgaaag cctgaccatt       60

aattgtgttc tgaccgatac cgattatggt ttgttctcca ccagctggtt tcgtaaaaat      120

ccgggtacaa ccgattggga acgtatgagc attggtggtc gttatgttga aagcgtgaat      180

aaaggtgcca aaagctttag cctgcgcatt aaagatctga ccgttgcaga tagcgcaacc      240

tattactgta aagcattcac ttggccgtgg gaatggccgg accgttggtt ccgtccgtgg      300

tatgatggtg caggcaccgt tctgaccgtt aatggcggtg gtggttctgg tggtggtgct      360

gatcaggagc ccaaatcttc tgacaaaact cacacatgtc caccgtgccc agcacctgaa      420

ctcctgggtg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      480

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      540

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      600

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      660

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      720

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca      780

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat      840

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc      900

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac      960

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1020

aaccactaca cgcagaagag cctctccctg tccccgggta aaaccgccgc cgccgccacc     1080

gccgccgccg ccaccgccgc cgccgccacc gccgcggccg ccacacgtgt tgatcagaca     1140

ccgcgtaccg caaccaaaga aaccggtgaa agcctgacca ttaattgtgt tctgaccgat     1200

accgagtatg gtttgttctc caccagctgg tttcgtaaaa atccgggtac aaccgattgg     1260

gaacgtatga gcattggtgg tcgttatgtt gaaagcgtga ataaaggtgc caaaagcttt     1320

agcctgcgca ttaaagatct gaccgttgca gatagcgcaa cctattactg taaagcactg     1380

ggttggtggc cgccggcttt cccgcattgg tatgatggtg caggcaccgt tctgaccgtt     1440

aat                                                                   1443


<210>  47
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR CC3-Fc-2D4 AMINO ACID SEQUENCE

<400>  47

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Glu Tyr Gly Leu Phe 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Leu Gly Trp Trp Pro Pro Ala Phe Pro His Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr Ala 
            340                 345                 350         


Ala Ala Ala Thr Ala Ala Ala Ala Thr Ala Ala Ala Ala Thr Ala Ala 
        355                 360                 365             


Ala Ala Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr 
    370                 375                 380                 


Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Asp Tyr Gly 
385                 390                 395                 400 


Leu Phe Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp 
                405                 410                 415     


Glu Arg Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly 
            420                 425                 430         


Ala Lys Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser 
        435                 440                 445             


Ala Thr Tyr Tyr Cys Lys Ala Phe Thr Trp Pro Trp Glu Trp Pro Asp 
    450                 455                 460                 


Arg Trp Phe Arg Pro Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val 
465                 470                 475                 480 


Asn 
    


<210>  48
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR CC3-Fc-2D4

<400>  48
acacgtgttg atcagacacc gcgtaccgca accaaagaaa ccggtgaaag cctgaccatt       60

aattgtgttc tgaccgatac cgagtatggt ttgttctcca ccagctggtt tcgtaaaaat      120

ccgggtacaa ccgattggga acgtatgagc attggtggtc gttatgttga aagcgtgaat      180

aaaggtgcca aaagctttag cctgcgcatt aaagatctga ccgttgcaga tagcgcaacc      240

tattactgta aagcactggg ttggtggccg ccggctttcc cgcattggta tgatggtgca      300

ggcaccgttc tgaccgttaa tggcggtggt ggttctggtg gtggtggtcg tacggagccc      360

aaatcttctg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgctggggca      420

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      480

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      540

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      600

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      660

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      720

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      780

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      840

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      900

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      960

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1020

cagaagagcc tctccctgtc cccgggtaaa accgccgccg ccgccaccgc cgccgccgcc     1080

accgccgccg ccgccaccgc cgcggccgcc acacgtgttg atcagacacc gcgtaccgca     1140

accaaagaaa ccggtgaaag cctgaccatt aattgtgttc tgaccgatac cgattatggt     1200

ttgttctcca ccagctggtt tcgtaaaaat ccgggtacaa ccgattggga acgtatgagc     1260

attggtggtc gttatgttga aagcgtgaat aaaggtgcca aaagctttag cctgcgcatt     1320

aaagatctga ccgttgcaga tagcgcaacc tattactgta aagcattcac ttggccgtgg     1380

gaatggccgg accgttggtt ccgtccgtgg tatgatggtg caggcaccgt tctgaccgtt     1440

aat                                                                   1443


<210>  49
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR CC3-Fc-CC3 AMINO ACID SEQUENCE

<400>  49

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Glu Tyr Gly Leu Phe 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Leu Gly Trp Trp Pro Pro Ala Phe Pro His Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr Ala 
            340                 345                 350         


Ala Ala Ala Thr Ala Ala Ala Ala Thr Ala Ala Ala Ala Thr Ala Ala 
        355                 360                 365             


Ala Ala Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr 
    370                 375                 380                 


Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Glu Tyr Gly 
385                 390                 395                 400 


Leu Phe Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp 
                405                 410                 415     


Glu Arg Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly 
            420                 425                 430         


Ala Lys Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser 
        435                 440                 445             


Ala Thr Tyr Tyr Cys Lys Ala Leu Gly Trp Trp Pro Pro Ala Phe Pro 
    450                 455                 460                 


His Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
465                 470                 475         


<210>  50
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS VNAR CC3-Fc-CC3

<400>  50
acacgtgttg atcagacacc gcgtaccgca accaaagaaa ccggtgaaag cctgaccatt       60

aattgtgttc tgaccgatac cgagtatggt ttgttctcca ccagctggtt tcgtaaaaat      120

ccgggtacaa ccgattggga acgtatgagc attggtggtc gttatgttga aagcgtgaat      180

aaaggtgcca aaagctttag cctgcgcatt aaagatctga ccgttgcaga tagcgcaacc      240

tattactgta aagcactggg ttggtggccg ccggctttcc cgcattggta tgatggtgca      300

ggcaccgttc tgaccgttaa tggcggtggt ggttctggtg gtggtggtcg tacggagccc      360

aaatcttctg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgctggggca      420

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      480

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      540

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      600

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      660

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      720

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      780

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      840

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      900

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      960

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1020

cagaagagcc tctccctgtc cccgggtaaa accgccgccg ccgccaccgc cgccgccgcc     1080

accgccgccg ccgccaccgc cgcggccgcc acacgtgttg atcagacacc gcgtaccgca     1140

accaaagaaa ccggtgaaag cctgaccatt aattgtgttc tgaccgatac cgagtatggt     1200

ttgttctcca ccagctggtt tcgtaaaaat ccgggtacaa ccgattggga acgtatgagc     1260

attggtggtc gttatgttga aagcgtgaat aaaggtgcca aaagctttag cctgcgcatt     1320

aaagatctga ccgttgcaga tagcgcaacc tattactgta aagcactggg ttggtggccg     1380

ccggctttcc cgcattggta tgatggtgca ggcaccgttc tgaccgttaa t              1431


<210>  51
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SoloMER VNAR D1-v1 AMINO ACID SEQUENCE WITH HIS TAG

<400>  51

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys His His His His His His 
            100                 105                 110         


<210>  52
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE SoloMER VNAR D1-v1 WITH HIS 
       TAG

<400>  52
gcccgcgtgg accagtcccc ctcctccctg tccgcctccg tgggcgaccg cgtgaccatc       60

acctgcgtgc tgcgcgactc ccactgcgcc acctcctcca cctactggta ccgcaagaag      120

tccggctcca ccaacgagga gtccatctcc aaggggggcc gctacgtgga gaccgtgaac      180

tccggctcca agtccttctc cctgcgcatc aacgacctga ccgtggagga ctccggcacc      240

taccgctgcg cctccgagtg ccagtacggc ctggccgagt acgacgtgta cggcggcggc      300

accaaggtgg agatcaagca ccaccaccac caccac                                336


<210>  53
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SoloMER VNAR D1-v2 AMINO ACID SEQUENCE WITH HIS TAG

<400>  53

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys His His His His His His 
            100                 105                 110         


<210>  54
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE SoloMER VNAR D1-v2 WITH HIS 
       TAG

<400>  54
gcccgcgtgg accagtcccc ctcctccctg tccgcctccg tgggcgaccg cgtgaccatc       60

acctgcgtgc tgcgcgactc ccactgcgcc acctcctcca cctactggta ccgcaagaag      120

tccggctcca ccaacgagga gtccatctcc aaggggggcc gctacgtgga gaccgtgaac      180

tccggctcca agtccttcac cctgaccatc tcctccctgc agcccgagga cttcgccacc      240

tactactgcg cctccgagtg ccagtacggc ctggccgagt acgacgtgta cggcggcggc      300

accaaggtgg agatcaagca ccaccaccac caccac                                336


<210>  55
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SoloMER VNAR D1-v3 AMINO ACID SEQUENCE WITH HIS TAG

<400>  55

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys His His His His His His 
            100                 105                 110         


<210>  56
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE SoloMER VNAR D1-v3 WITH HIS 
       TAG

<400>  56
gcccgcgtgg accagtcccc ctcctccctg tccgcctccg tgggcgaccg cgtgaccatc       60

acctgcgtgc tgcgcgactc ccactgcgcc acctcctcca cctactggta ccagcagaag      120

cccggcaaga ccaacgagga gtccatctcc aaggggggcc gctacgtgga gaccgtgaac      180

tccggctcca agtccttcac cctgaccatc tcctccctgc agcccgagga cttcgccacc      240

tactactgcg cctccgagtg ccagtacggc ctggccgagt acgacgtgta cggcggcggc      300

accaaggtgg agatcaagca ccaccaccac caccac                                336


<210>  57
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SoloMER VNAR D1-v4 AMINO ACID SEQUENCE WITH HIS TAG

<400>  57

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Pro Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Phe Ser Gly Ser Gly Ser Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys His His His His His His 
            100                 105                 110         


<210>  58
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE SoloMER VNAR D1-v4 WITH HIS 
       TAG

<400>  58
gcccgcgtgg accagtcccc ctcctccctg tccgcctccg tgggcgaccg cgtgaccatc       60

acctgcgtgc tgcgcgactc ccactgcgcc acctcctcca cctactggta ccgcaagaag      120

cccggctcca ccaacgagga gtccatctcc aaggggggcc gcttctccgg ctccggctcc      180

tccggctcca agtccttcac cctgaccatc tcctccctgc agcccgagga cttcgccacc      240

tactactgcg cctccgagtg ccagtacggc ctggccgagt acgacgtgtt cggccagggc      300

accaaggtgg agatcaagca ccaccaccac caccac                                336


<210>  59
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Quad-X D1-Fc-C4 AMINO ACID SEQUENCE

<400>  59

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro Gln Thr Ile 
    370                 375                 380                 


Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu Arg Asp 
385                 390                 395                 400 


Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly 
                405                 410                 415     


Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr 
            420                 425                 430         


Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr 
        435                 440                 445             


Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln 
    450                 455                 460                 


Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly Thr Val Val 
465                 470                 475                 480 


Thr Val Asn 
            


<210>  60
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE Quad-X D1-Fc-C4

<400>  60
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg atccggtggt gggtccggag gaggtggctc aggagagccc      360

aaatctagcg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      420

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      480

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      540

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      600

agcacgtacc gggtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      660

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      720

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      780

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      840

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      900

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      960

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1020

cagaagagcc tctccctgtc tccggggaaa ggaggtggcg gttccggagg tggcggtagc     1080

ggaggtggcg gtagcggagg tggcggtagc ggggcccatt ctgctcgagt ggaccaaaca     1140

ccgcaaacaa taacaaagga gacgggcgaa tcactgacca tcaactgtgt cctacgagat     1200

agcaactgtg ggttgtccag cacgtactgg tatcgcaaaa aatcgggctc aacaaacgag     1260

gagagcatat cgaaaggtgg acgatatgtt gaaacaatta acgaaggatc aaagtccttt     1320

tctttgagaa ttaatgatct aacagttgaa gacagtggca cgtatcgatg caagttaagc     1380

tggtggaccc agaactggag atgctcaaat tccgatgtat acggaggtgg cactgtcgtg     1440

actgtgaat                                                             1449


<210>  61
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Quad-Y-D1C4 D1-C4-Fc AMINO ACID SEQUENCE

<400>  61

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp Gln Thr Pro 
        115                 120                 125             


Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val 
    130                 135                 140                 


Leu Arg Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr 
                165                 170                 175     


Val Glu Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn 
            180                 185                 190         


Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp 
        195                 200                 205             


Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly 
    210                 215                 220                 


Thr Val Val Thr Val Asn Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  62
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE Quad-Y-D1C4 AMINO ACID 
       SEQUENCE

<400>  62
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcggt agcggaggtg gtggcggatc cggggcgcac      360

tccgctcgag tggaccaaac accgcaaaca ataacaaagg agacgggcga atcactgacc      420

atcaactgtg tcctacgaga tagcaactgt gggttgtcca gcacgtactg gtatcgcaaa      480

aaatcgggct caacaaacga ggagagcata tcgaaaggtg gacgatatgt tgaaacaatt      540

aacgaaggat caaagtcctt ttctttgaga attaatgatc taacagttga agacagtggc      600

acgtatcgat gcaagttaag ctggtggacc cagaactgga gatgctcaaa ttccgatgta      660

tacggaggtg gcactgtcgt gactgtgaac ggtggtgggt ccggaggagg tggctcagga      720

gagcccaaat ctagcgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      780

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg gggaaa                               1416


<210>  63
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Quad-Y-C4D1 C4-D1-Fc AMINO ACID SEQUENCE

<400>  63

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser Asn Cys Gly Leu Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg Cys Ser Asn 
                85                  90                  95      


Ser Asp Val Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Gly Ser Gly Ala His Ser Ala Arg Val Asp 
        115                 120                 125             


Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile 
    130                 135                 140                 


Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser Ser Thr Tyr Trp 
145                 150                 155                 160 


Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly 
                165                 170                 175     


Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys Ser Phe Ser Leu 
            180                 185                 190         


Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Ala 
        195                 200                 205             


Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val Tyr Gly Gly Gly 
    210                 215                 220                 


Thr Val Val Thr Val Asn Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  64
<211>  1416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NUCLEOTIDE SEQUENCE CODING FOR THE Quad-Y-C4D1 AMINO ACID 
       SEQUENCE

<400>  64

Gly Cys Thr Cys Gly Ala Gly Thr Gly Gly Ala Cys Cys Ala Ala Ala 
1               5                   10                  15      


Cys Ala Cys Cys Gly Cys Ala Ala Ala Cys Ala Ala Thr Ala Ala Cys 
            20                  25                  30          


Ala Ala Ala Gly Gly Ala Gly Ala Cys Gly Gly Gly Cys Gly Ala Ala 
        35                  40                  45              


Thr Cys Ala Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Ala Cys Thr 
    50                  55                  60                  


Gly Thr Gly Thr Cys Cys Thr Ala Cys Gly Ala Gly Ala Thr Ala Gly 
65                  70                  75                  80  


Cys Ala Ala Cys Thr Gly Thr Gly Gly Gly Thr Thr Gly Thr Cys Cys 
                85                  90                  95      


Ala Gly Cys Ala Cys Gly Thr Ala Cys Thr Gly Gly Thr Ala Thr Cys 
            100                 105                 110         


Gly Cys Ala Ala Ala Ala Ala Ala Thr Cys Gly Gly Gly Cys Thr Cys 
        115                 120                 125             


Ala Ala Cys Ala Ala Ala Cys Gly Ala Gly Gly Ala Gly Ala Gly Cys 
    130                 135                 140                 


Ala Thr Ala Thr Cys Gly Ala Ala Ala Gly Gly Thr Gly Gly Ala Cys 
145                 150                 155                 160 


Gly Ala Thr Ala Thr Gly Thr Thr Gly Ala Ala Ala Cys Ala Ala Thr 
                165                 170                 175     


Thr Ala Ala Cys Gly Ala Ala Gly Gly Ala Thr Cys Ala Ala Ala Gly 
            180                 185                 190         


Thr Cys Cys Thr Thr Thr Thr Cys Thr Thr Thr Gly Ala Gly Ala Ala 
        195                 200                 205             


Thr Thr Ala Ala Thr Gly Ala Thr Cys Thr Ala Ala Cys Ala Gly Thr 
    210                 215                 220                 


Thr Gly Ala Ala Gly Ala Cys Ala Gly Thr Gly Gly Cys Ala Cys Gly 
225                 230                 235                 240 


Thr Ala Thr Cys Gly Ala Thr Gly Cys Ala Ala Gly Thr Thr Ala Ala 
                245                 250                 255     


Gly Cys Thr Gly Gly Thr Gly Gly Ala Cys Cys Cys Ala Gly Ala Ala 
            260                 265                 270         


Cys Thr Gly Gly Ala Gly Ala Thr Gly Cys Thr Cys Ala Ala Ala Thr 
        275                 280                 285             


Thr Cys Cys Gly Ala Thr Gly Thr Ala Thr Ala Cys Gly Gly Ala Gly 
    290                 295                 300                 


Gly Thr Gly Gly Cys Ala Cys Thr Gly Thr Cys Gly Thr Gly Ala Cys 
305                 310                 315                 320 


Thr Gly Thr Gly Ala Ala Cys Gly Gly Ala Gly Gly Thr Gly Gly Cys 
                325                 330                 335     


Gly Gly Thr Ala Gly Cys Gly Gly Ala Gly Gly Thr Gly Gly Thr Gly 
            340                 345                 350         


Gly Cys Gly Gly Ala Thr Cys Cys Gly Gly Gly Gly Cys Gly Cys Ala 
        355                 360                 365             


Cys Thr Cys Cys Gly Cys Thr Cys Gly Ala Gly Thr Gly Gly Ala Cys 
    370                 375                 380                 


Cys Ala Ala Ala Cys Ala Cys Cys Gly Cys Ala Ala Ala Cys Ala Ala 
385                 390                 395                 400 


Thr Ala Ala Cys Ala Ala Ala Gly Gly Ala Gly Ala Cys Gly Gly Gly 
                405                 410                 415     


Cys Gly Ala Ala Thr Cys Ala Cys Thr Gly Ala Cys Cys Ala Thr Cys 
            420                 425                 430         


Ala Ala Cys Thr Gly Thr Gly Thr Cys Cys Thr Ala Cys Gly Ala Gly 
        435                 440                 445             


Ala Thr Ala Gly Cys Cys Ala Cys Thr Gly Thr Gly Cys Ala Ala Cys 
    450                 455                 460                 


Cys Thr Cys Cys Ala Gly Cys Ala Cys Gly Thr Ala Cys Thr Gly Gly 
465                 470                 475                 480 


Thr Ala Thr Cys Gly Cys Ala Ala Ala Ala Ala Ala Thr Cys Gly Gly 
                485                 490                 495     


Gly Cys Thr Cys Ala Ala Cys Ala Ala Ala Cys Gly Ala Gly Gly Ala 
            500                 505                 510         


Gly Ala Gly Cys Ala Thr Ala Thr Cys Gly Ala Ala Ala Gly Gly Thr 
        515                 520                 525             


Gly Gly Ala Cys Gly Ala Thr Ala Thr Gly Thr Thr Gly Ala Ala Ala 
    530                 535                 540                 


Cys Ala Gly Thr Thr Ala Ala Cys Ala Gly Cys Gly Gly Ala Thr Cys 
545                 550                 555                 560 


Ala Ala Ala Gly Thr Cys Cys Thr Thr Thr Thr Cys Thr Thr Thr Gly 
                565                 570                 575     


Ala Gly Ala Ala Thr Thr Ala Ala Thr Gly Ala Thr Cys Thr Ala Ala 
            580                 585                 590         


Cys Ala Gly Thr Thr Gly Ala Ala Gly Ala Cys Ala Gly Thr Gly Gly 
        595                 600                 605             


Cys Ala Cys Gly Thr Ala Thr Cys Gly Ala Thr Gly Cys Gly Cys Thr 
    610                 615                 620                 


Thr Cys Cys Gly Ala Gly Thr Gly Cys Cys Ala Ala Thr Ala Thr Gly 
625                 630                 635                 640 


Gly Ala Cys Thr Gly Gly Cys Ala Gly Ala Ala Thr Ala Thr Gly Ala 
                645                 650                 655     


Thr Gly Thr Ala Thr Ala Cys Gly Gly Ala Gly Gly Thr Gly Gly Cys 
            660                 665                 670         


Ala Cys Thr Gly Thr Cys Gly Thr Gly Ala Cys Thr Gly Thr Gly Ala 
        675                 680                 685             


Ala Thr Gly Gly Thr Gly Gly Thr Gly Gly Gly Thr Cys Cys Gly Gly 
    690                 695                 700                 


Ala Gly Gly Ala Gly Gly Thr Gly Gly Cys Thr Cys Ala Gly Gly Ala 
705                 710                 715                 720 


Gly Ala Gly Cys Cys Cys Ala Ala Ala Thr Cys Thr Ala Gly Cys Gly 
                725                 730                 735     


Ala Cys Ala Ala Ala Ala Cys Thr Cys Ala Cys Ala Cys Ala Thr Gly 
            740                 745                 750         


Cys Cys Cys Ala Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala 
        755                 760                 765             


Cys Cys Thr Gly Ala Ala Cys Thr Cys Cys Thr Gly Gly Gly Gly Gly 
    770                 775                 780                 


Gly Ala Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys Cys Thr 
785                 790                 795                 800 


Cys Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys Cys Cys 
                805                 810                 815     


Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr Gly Ala 
            820                 825                 830         


Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr Gly Ala 
        835                 840                 845             


Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr Gly Gly Thr Gly 
    850                 855                 860                 


Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly 
865                 870                 875                 880 


Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly Gly Thr Cys Ala Ala 
                885                 890                 895     


Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly 
            900                 905                 910         


Gly Ala Cys Gly Gly Cys Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys 
        915                 920                 925             


Ala Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly Ala Cys Ala Ala Ala 
    930                 935                 940                 


Gly Cys Cys Gly Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly 
945                 950                 955                 960 


Thr Ala Cys Ala Ala Cys Ala Gly Cys Ala Cys Gly Thr Ala Cys Cys 
                965                 970                 975     


Gly Thr Gly Thr Gly Gly Thr Cys Ala Gly Cys Gly Thr Cys Cys Thr 
            980                 985                 990         


Cys Ala Cys Cys Gly Thr Cys Cys  Thr Gly Cys Ala Cys  Cys Ala Gly 
        995                 1000                 1005             


Gly Ala  Cys Thr Gly Gly Cys  Thr Gly Ala Ala Thr  Gly Gly Cys 
    1010                 1015                 1020             


Ala Ala  Gly Gly Ala Gly Thr  Ala Cys Ala Ala Gly  Thr Gly Cys 
    1025                 1030                 1035             


Ala Ala  Gly Gly Thr Cys Thr  Cys Cys Ala Ala Cys  Ala Ala Ala 
    1040                 1045                 1050             


Gly Cys  Cys Cys Thr Cys Cys  Cys Ala Gly Cys Cys  Cys Cys Cys 
    1055                 1060                 1065             


Ala Thr  Cys Gly Ala Gly Ala  Ala Ala Ala Cys Cys  Ala Thr Cys 
    1070                 1075                 1080             


Thr Cys  Cys Ala Ala Ala Gly  Cys Cys Ala Ala Ala  Gly Gly Gly 
    1085                 1090                 1095             


Cys Ala  Gly Cys Cys Cys Cys  Gly Ala Gly Ala Ala  Cys Cys Ala 
    1100                 1105                 1110             


Cys Ala  Gly Gly Thr Gly Thr  Ala Cys Ala Cys Cys  Cys Thr Gly 
    1115                 1120                 1125             


Cys Cys  Cys Cys Cys Ala Thr  Cys Cys Cys Gly Gly  Gly Ala Thr 
    1130                 1135                 1140             


Gly Ala  Gly Cys Thr Gly Ala  Cys Cys Ala Ala Gly  Ala Ala Cys 
    1145                 1150                 1155             


Cys Ala  Gly Gly Thr Cys Ala  Gly Cys Cys Thr Gly  Ala Cys Cys 
    1160                 1165                 1170             


Thr Gly  Cys Cys Thr Gly Gly  Thr Cys Ala Ala Ala  Gly Gly Cys 
    1175                 1180                 1185             


Thr Thr  Cys Thr Ala Thr Cys  Cys Cys Ala Gly Cys  Gly Ala Cys 
    1190                 1195                 1200             


Ala Thr  Cys Gly Cys Cys Gly  Thr Gly Gly Ala Gly  Thr Gly Gly 
    1205                 1210                 1215             


Gly Ala  Gly Ala Gly Cys Ala  Ala Thr Gly Gly Gly  Cys Ala Gly 
    1220                 1225                 1230             


Cys Cys  Gly Gly Ala Gly Ala  Ala Cys Ala Ala Cys  Thr Ala Cys 
    1235                 1240                 1245             


Ala Ala  Gly Ala Cys Cys Ala  Cys Gly Cys Cys Thr  Cys Cys Cys 
    1250                 1255                 1260             


Gly Thr  Gly Cys Thr Gly Gly  Ala Cys Thr Cys Cys  Gly Ala Cys 
    1265                 1270                 1275             


Gly Gly  Cys Thr Cys Cys Thr  Thr Cys Thr Thr Cys  Cys Thr Cys 
    1280                 1285                 1290             


Thr Ala  Cys Ala Gly Cys Ala  Ala Gly Cys Thr Cys  Ala Cys Cys 
    1295                 1300                 1305             


Gly Thr  Gly Gly Ala Cys Ala  Ala Gly Ala Gly Cys  Ala Gly Gly 
    1310                 1315                 1320             


Thr Gly  Gly Cys Ala Gly Cys  Ala Gly Gly Gly Gly  Ala Ala Cys 
    1325                 1330                 1335             


Gly Thr  Cys Thr Thr Cys Thr  Cys Ala Thr Gly Cys  Thr Cys Cys 
    1340                 1345                 1350             


Gly Thr  Gly Ala Thr Gly Cys  Ala Thr Gly Ala Gly  Gly Cys Thr 
    1355                 1360                 1365             


Cys Thr  Gly Cys Ala Cys Ala  Ala Cys Cys Ala Cys  Thr Ala Cys 
    1370                 1375                 1380             


Ala Cys  Gly Cys Ala Gly Ala  Ala Gly Ala Gly Cys  Cys Thr Cys 
    1385                 1390                 1395             


Thr Cys  Cys Cys Thr Gly Thr  Cys Thr Cys Cys Gly  Gly Gly Gly 
    1400                 1405                 1410             


Ala Ala  Ala 
    1415     


<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2D4

<400>  65

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Asp Tyr Gly Leu Phe 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Phe Thr Trp Pro Trp Glu Trp Pro Asp Arg Trp 
                85                  90                  95      


Phe Arg Pro Trp Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105                 110     


<210>  66
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC3

<400>  66

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Glu Tyr Gly Leu Phe 
            20                  25                  30          


Ser Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Lys Ala Leu Gly Trp Trp Pro Pro Ala Phe Pro His Trp 
                85                  90                  95      


Tyr Asp Gly Ala Gly Thr Val Leu Thr Val Asn 
            100                 105         


<210>  67
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BA11

<400>  67

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Ser Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha specific VNAR binding domain CDR1

<400>  68

His Cys Ala Thr Ser Ser 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha spcific VNAR binding domain CDR1

<400>  69

Asn Cys Gly Leu Ser Ser 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha specific VNAR binding domain CDR1

<400>  70

Asn Cys Ala Leu Ser Ser 
1               5       


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha specific VNAR binding domain hyper-variable region 2

<400>  71

Thr Asn Glu Glu Ser Ile Ser Lys Gly 
1               5                   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha specific VNAR binding domain hyper-variable region 4

<400>  72

Ser Gly Ser Lys Ser 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TNF-alpha specific VNAR binding domain hyper-variable region 4

<400>  73

Glu Gly Ser Lys Ser 
1               5   


<210>  74
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NARF4For1 primer

<400>  74
ataatcaagc ttgcggccgc attcacagtc acgacagtgc cacctc                      46


<210>  75
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NARF4For2 primer

<400>  75
ataatcaagc ttgcggccgc attcacagtc acggcagtgc catctc                      46


<210>  76
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NARF1Rev primer

<400>  76
ataataagga attccatggc tcgagtggac caaacaccg                              39


<210>  77
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E06

<400>  77

Thr Arg Val Asp Gln Thr Pro Arg Thr Ala Thr Arg Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Ile Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Val Leu Thr Val Asn 
            100             


<210>  78
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hE06v1.10

<400>  78

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  79
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AC9

<400>  79

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  80
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AD4

<400>  80

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Met Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Ser Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  81
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AG11

<400>  81

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Thr Lys 
            100             


<210>  82
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH7

<400>  82

Thr Arg Val Asp Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  83
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BB10

<400>  83

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Phe Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  84
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BB11

<400>  84

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Ala Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  85
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC3

<400>  85

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Asn Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  86
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BD12

<400>  86

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Asn 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  87
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BE4

<400>  87

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Ser Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Ile Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  88
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BH4

<400>  88

Thr Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Thr Asp Thr Ser Tyr Pro Leu Tyr 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Asn Pro Gly Ser Ser Asn Lys Glu Gln 
        35                  40                  45              


Ile Ser Ile Ser Gly Arg Tyr Ser Glu Ser Val Asn Lys Gly Thr Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Arg Ala Met Gly Thr Asn Leu Trp Thr Gly Asp Gly Ala 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys 
            100             


<210>  89
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  89

Ala Arg Val Asp Gln Thr Pro Gln Thr Ile Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp Ser Gly Thr 
65                  70                  75                  80  


Tyr Arg Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Val Val Thr Val Asn Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Ser Ala Arg Val Asp Gln Thr Pro 
        115                 120                 125             


Gln Thr Ile Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val 
    130                 135                 140                 


Leu Arg Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr 
                165                 170                 175     


Val Glu Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn 
            180                 185                 190         


Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp 
        195                 200                 205             


Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly 
    210                 215                 220                 


Thr Val Val Thr Val Asn Ala Ala Ala His His His His His His 
225                 230                 235                 


<210>  90
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  90
gctcgagtgg accaaacacc gcaaacaata acaaaggaga cgggcgaatc actgaccatc       60

aactgtgtcc tacgagatag ccactgtgca acctccagca cgtactggta tcgcaaaaaa      120

tcgggctcaa caaacgagga gagcatatcg aaaggtggac gatatgttga aacagttaac      180

agcggatcaa agtccttttc tttgagaatt aatgatctaa cagttgaaga cagtggcacg      240

tatcgatgcg cttccgagtg ccaatatgga ctggcagaat atgatgtata cggaggtggc      300

actgtcgtga ctgtgaatgg aggtggcggt agcggaggtg gtggcggatc cggcggtggt      360

tccgctcgag tggaccaaac accgcaaaca ataacaaagg agacgggcga atcactgacc      420

atcaactgtg tcctacgaga tagcaactgt gggttgtcca gcacgtactg gtatcgcaaa      480

aaatcgggct caacaaacga ggagagcata tcgaaaggtg gacgatatgt tgaaacaatt      540

aacgaaggat caaagtcctt ttctttgaga attaatgatc taacagttga agacagtggc      600

acgtatcgat gcaagttaag ctggtggacc cagaactgga gatgctcaaa ttccgatgta      660

tacggaggtg gcactgtcgt gactgtgaac gcggccgcac atcatcatca ccatcac         717


<210>  91
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  91

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Ser Ala Arg Val Asp Gln Ser Pro 
        115                 120                 125             


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Val 
    130                 135                 140                 


Leu Arg Asp Ser Asn Cys Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys 
145                 150                 155                 160 


Lys Ser Gly Ser Thr Asn Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr 
                165                 170                 175     


Val Glu Thr Ile Asn Glu Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn 
            180                 185                 190         


Asp Leu Thr Val Glu Asp Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp 
        195                 200                 205             


Trp Thr Gln Asn Trp Arg Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly 
    210                 215                 220                 


Thr Lys Val Glu Ile Lys Ala Ala Ala His His His His His His 
225                 230                 235                 


<210>  92
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  92
gcccgcgtgg accagtcccc ctcctccctg tccgcctccg tgggcgaccg cgtgaccatc       60

acctgcgtgc tgcgcgactc ccactgcgcc acctcctcca cctactggta ccgcaagaag      120

tccggctcca ccaacgagga gtccatctcc aaggggggcc gctacgtgga gaccgtgaac      180

tccggctcca agtccttcac cctgaccatc tcctccctgc agcccgagga cttcgccacc      240

tactactgcg cctccgagtg ccagtacggc ctggccgagt acgacgtgta cggcggcggc      300

accaaggtgg agatcaaggg aggtggcggt agcggaggtg gtggcggatc cggcggtggt      360

tccgcccgcg tggaccagtc cccctcctcc ctgtccgcct ccgtgggcga ccgcgtgacc      420

atcacctgcg tgctgcgcga ctccaactgc ggcctgtcct ccacctactg gtaccgcaag      480

aagtccggct ccaccaacga ggagtccatc tccaagggcg gccgctacgt ggagaccatc      540

aacgagggct ccaagtcctt ctccctgcgc atcaacgacc tgaccgtgga ggactccggc      600

acctaccgct gcaagctgtc ctggtggacc cagaactggc gctgctccaa ctccgacgtg      660

tacggcggcg gcaccaaggt ggagatcaag gcggccgcac atcatcatca ccatcac         717


<210>  93
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  93

Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser His Cys Ala Thr Ser 
            20                  25                  30          


Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn Glu Glu Ser 
        35                  40                  45              


Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Val Asn Ser Gly Ser Lys 
    50                  55                  60                  


Ser Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
65                  70                  75                  80  


Tyr Tyr Cys Ala Ser Glu Cys Gln Tyr Gly Leu Ala Glu Tyr Asp Val 
                85                  90                  95      


Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ala Arg Val Asp Gln Ser Pro Ser Ser Leu Ser Ala Ser 
    130                 135                 140                 


Val Gly Asp Arg Val Thr Ile Thr Cys Val Leu Arg Asp Ser Asn Cys 
145                 150                 155                 160 


Gly Leu Ser Ser Thr Tyr Trp Tyr Arg Lys Lys Ser Gly Ser Thr Asn 
                165                 170                 175     


Glu Glu Ser Ile Ser Lys Gly Gly Arg Tyr Val Glu Thr Ile Asn Glu 
            180                 185                 190         


Gly Ser Lys Ser Phe Ser Leu Arg Ile Asn Asp Leu Thr Val Glu Asp 
        195                 200                 205             


Ser Gly Thr Tyr Arg Cys Lys Leu Ser Trp Trp Thr Gln Asn Trp Arg 
    210                 215                 220                 


Cys Ser Asn Ser Asp Val Tyr Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Ala Ala Ala His His His His His His 
                245                 


<210>  94
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  94
gcccgcgtgg accagtcccc ctcctccctg tccgcctccg tgggcgaccg cgtgaccatc       60

acctgcgtgc tgcgcgactc ccactgcgcc acctcctcca cctactggta ccgcaagaag      120

tccggctcca ccaacgagga gtccatctcc aaggggggcc gctacgtgga gaccgtgaac      180

tccggctcca agtccttcac cctgaccatc tcctccctgc agcccgagga cttcgccacc      240

tactactgcg cctccgagtg ccagtacggc ctggccgagt acgacgtgta cggcggcggc      300

accaaggtgg agatcaaggg tggtggtggt agcggtggtg gcggttcagg tggcggtggt      360

tctggcggtg gcggtagtgg cggaggtggt agtgcccgcg tggaccagtc cccctcctcc      420

ctgtccgcct ccgtgggcga ccgcgtgacc atcacctgcg tgctgcgcga ctccaactgc      480

ggcctgtcct ccacctactg gtaccgcaag aagtccggct ccaccaacga ggagtccatc      540

tccaagggcg gccgctacgt ggagaccatc aacgagggct ccaagtcctt ctccctgcgc      600

atcaacgacc tgaccgtgga ggactccggc acctaccgct gcaagctgtc ctggtggacc      660

cagaactggc gctgctccaa ctccgacgtg tacggcggcg gcaccaaggt ggagatcaag      720

gcggccgcac atcatcatca ccatcac                                          747


<210>  95
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  95

Ala Ser Val Asn Gln Thr Pro Arg Thr Ala Thr Lys Glu Thr Gly Glu 
1               5                   10                  15      


Ser Leu Thr Ile Asn Cys Val Leu Thr Asp Thr His Ala Lys Val Phe 
            20                  25                  30          


Thr Thr Ser Trp Phe Arg Lys Asn Pro Gly Thr Thr Asp Trp Glu Arg 
        35                  40                  45              


Met Ser Ile Gly Gly Arg Tyr Val Glu Ser Val Asn Lys Gly Ala Lys 
    50                  55                  60                  


Ser Phe Ser Leu Arg Ile Lys Asp Leu Thr Val Ala Asp Ser Ala Thr 
65                  70                  75                  80  


Tyr Ile Cys Arg Ala Gly Gly Tyr Leu Ser Gln Pro Arg Val Tyr Trp 
                85                  90                  95      


Asp Val Tyr Gly Ala Gly Thr Val Leu Thr Val Asn Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Arg Thr Glu Pro Arg Gly Pro Thr Ile Lys Pro 
        115                 120                 125             


Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser 
    130                 135                 140                 


Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
145                 150                 155                 160 


Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
                165                 170                 175     


Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
            180                 185                 190         


Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
        195                 200                 205             


Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
    210                 215                 220                 


Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
225                 230                 235                 240 


Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
                245                 250                 255     


Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
            260                 265                 270         


Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
        275                 280                 285             


Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
    290                 295                 300                 


Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
305                 310                 315                 320 


Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
                325                 330                 335     


Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Ala His Ser Ala Ser Val Asn Gln Thr Pro Arg 
    370                 375                 380                 


Thr Ala Thr Lys Glu Thr Gly Glu Ser Leu Thr Ile Asn Cys Val Leu 
385                 390                 395                 400 


Thr Asp Thr His Ala Lys Val Phe Thr Thr Ser Trp Phe Arg Lys Asn 
                405                 410                 415     


Pro Gly Thr Thr Asp Trp Glu Arg Met Ser Ile Gly Gly Arg Tyr Val 
            420                 425                 430         


Glu Ser Val Asn Lys Gly Ala Lys Ser Phe Ser Leu Arg Ile Lys Asp 
        435                 440                 445             


Leu Thr Val Ala Asp Ser Ala Thr Tyr Ile Cys Arg Ala Gly Gly Tyr 
    450                 455                 460                 


Leu Ser Gln Pro Arg Val Tyr Trp Asp Val Tyr Gly Ala Gly Thr Val 
465                 470                 475                 480 


Leu Thr Val Asn 
                


<210>  96
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  96
gcaagcgtta atcagacacc gcgtaccgca accaaagaaa ccggtgaaag cctgaccatt       60

aattgtgttc tgaccgatac ccatgctaaa gttttcacta ccagctggtt tcgtaaaaat      120

ccgggtacaa ccgattggga acgtatgagc attggtggtc gttatgttga aagcgtgaat      180

aaaggtgcca aaagctttag cctgcgcatt aaagatctga ccgttgcaga tagcgcaacc      240

tatatctgtc gtgccggtgg ttacctgtct cagccgcgtg tttactggga tgtttatggt      300

gcaggcaccg ttctgaccgt taatggcggt ggtggttctg gtggtggtgg tcgtacggag      360

cctcgaggcc ccacaatcaa gccctgtcct ccatgcaaat gcccagcacc taacctcttg      420

ggtggaccat ccgtcttcat cttccctcca aagatcaagg atgtactcat gatctccctg      480

agccccatag tcacatgtgt ggtggtggat gtgagcgagg atgacccaga tgtccagatc      540

agctggtttg tgaacaacgt ggaagtacac acagctcaga cacaaaccca tagagaggat      600

tacaacagta ctctccgggt ggtcagtgcc ctccccatcc agcaccagga ctggatgagt      660

ggcaaggagt tcaaatgcaa ggtcaacaac aaagacctcc cagcgcccat cgagagaacc      720

atctcaaaac ccaaagggtc agtaagagct ccacaggtat atgtcttgcc tccaccagaa      780

gaagagatga ctaagaaaca ggtcactctg acctgcatgg tcacagactt catgcctgaa      840

gacatttacg tggagtggac caacaacggg aaaacagagc taaactacaa gaacactgaa      900

ccagtcctgg actctgatgg ttcttacttc atgtacagca agctgagagt ggaaaagaag      960

aactgggtgg aaagaaatag ctactcctgt tcagtggtcc acgagggtct gcacaatcac     1020

cacacgacta agagcttctc ccggactccg ggtaaaggag gtggcggttc cggaggtggc     1080

ggtagcggag gtggcggtag cggaggtggc ggtagcgggg cccattctgc aagcgttaat     1140

cagacaccgc gtaccgcaac caaagaaacc ggtgaaagcc tgaccattaa ttgtgttctg     1200

accgataccc atgctaaagt tttcactacc agctggtttc gtaaaaatcc gggtacaacc     1260

gattgggaac gtatgagcat tggtggtcgt tatgttgaaa gcgtgaataa aggtgccaaa     1320

agctttagcc tgcgcattaa agatctgacc gttgcagata gcgcaaccta tatctgtcgt     1380

gccggtggtt acctgtctca gccgcgtgtt tactgggatg tttatggtgc aggcaccgtt     1440

ctgaccgtta at                                                         1452


