SEQUENCE LISTING

<110>  ϾƼ޹˾
<120>  һͿɵص˫ǶϿԭ塢Tϸ乹Ӧ
<160>  13
<170>  Patent In version 3.3
<210>  1
<211>  3911   
<212>  DNA
<213>  ˹
<400>  1
gccaccatgg ccttaccagt gaccgccttg ctcctgccgc tggccttgct gctccacgcc 60
gccaggccgg gatcccaggt acaactgcag cagtctgggc ctgagctgga gaagcctggc 120
gcttcagtga agatatcctg caaggcttct ggttactcat tcactggcta caccatgaac 180
tgggtgaagc agagccatgg aaagagcctt gagtggattg gacttattac tccttacaat 240
ggtgcttcta gctacaacca gaagttcagg ggcaaggcca cattaactgt agacaagtca 300
tccagcacag cctacatgga cctcctcagt ctgacatctg aagactctgc agtctatttc 360
tgtgcaaggg ggggttacga cgggaggggt tttgactact ggggccaagg gaccacggtc 420
accgtctcct caggtggagg cggttcaggc ggcggtggct ctagcggtgg tggatcggac 480
atcgagctca ctcagtctcc agcaatcatg tctgcatctc caggggagaa ggtcaccatg 540
acctgcagtg ccagctcaag tgtaagttac atgcactggt accagcagaa gtcaggcacc 600
tcccccaaaa gatggattta tgacacatcc aaactggctt ctggagtccc aggtcgcttc 660
agtggcagtg ggtctggaaa ctcttactct ctcacaatca gcagcgtgga ggctgaagat 720
gatgcaactt attactgcca gcagtggagt aagcaccctc tcacgtacgg tgctgggaca 780
aagttggaaa tcaaaagcag caccactacc ccagcaccga ggccacccac cccggctcct 840
accatcgcct cccagcctct gtccctgcgt ccggaggcat gtagacccgc agctggtggg 900
gccgtgcata cccggggtct tgacttcgcc tgcgatatct acatttgggc ccctctggct 960
ggtacttgcg gggtcctgct gctttcactc gtgatcactc tttactgtaa gcgcggtcgg 1020
aagaagctgc tgtacatctt taagcaaccc ttcatgaggc ctgtgcagac tactcaagag 1080
gaggacggct gttcatgccg gttcccagag gaggaggaag gcggctgcga actgtaagaa 1140
ttctgcagat atccgcccct ctccctcccc cccccctaac gttactggcc gaagccgctt 1200
ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc cgtcttttgg 1260
caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc 1320
ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga 1380
agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc 1440
tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc 1500
acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc 1560
aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga 1620
tctggggcct cggtgcacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg 1680
ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataag cttgccacaa 1740
cccacaagga gacgaccttc cgcggccgca tggccctccc tgtcaccgcc ctgctgcttc 1800
cgctggctct tctgctccac gccgctcggc ccgctagcga cgtcgttatg actcaaacac 1860
cactatcact tcctgttagt ctaggtgatc aagcctccat ctcttgcaga tctagtcaga 1920
gcctcgtaca cagtaatgga aacacctatt tacgttggta cctgcagaag ccaggccagt 1980
ctccaaaggt cctgatctac aaagtttcca accgagtttc tggggtccca gacaggttca 2040
gtggcagtgg atcagggaca gatttcacac tcaagatcaa cagagtggag gctgaggatc 2100
tgggagttta tttctgctct caaagtacac atgttccgtg gacgttcggt ggaggcacca 2160
agcttgaaat taagtcctct gctgatgatg ctaagaagga tgctgctaag aaggatgatg 2220
ctaagaaaga tgatgctaag aaagatggtg gcgtcaaact ggatgagact ggaggaggct 2280
tggtgcaacc tgggggggcc atgaaactct cctgtgttac ctctggattc acttttggtc 2340
actactggat gaactgggtc cgccagtctc cagagaaagg actggagtgg gtagcacaat 2400
ttagaaacaa accttataat tatgaaacat attattcaga ttctgtgaaa ggcagattca 2460
ccatctcaag agatgattcc aaaagtagtg tctatctgca aatgaacaac ttaagagttg 2520
aagacacggg tatctattac tgtacgggtg cttcctatgg tatggaatac ttgggtcaag 2580
gaacctcagt caccgtctcc accactaccc cagcaccgag gccacccacc ccggctccta 2640
ccatcgcctc ccagcctctg tccctgcgtc cggaggcatg tagacccgca gctggtgggg 2700
ccgtgcatac ccggggtctt gacttcgcct gcgatatcta catttgggcc cctctggctg 2760
gtacttgcgg ggtcctgctg ctttcactcg tgatcactct ttactgtcgc gtgaaattca 2820
gccgcagcgc agatgctcca gcctaccagc aggggcagaa ccagctctac aacgaactca 2880
atcttggtcg gagagaggag tacgacgtgc tggacaagcg gagaggacgg gacccagaaa 2940
tgggcgggaa gccgcgcaga aagaatcccc aagagggcct gtacaacgag ctccaaaagg 3000
ataagatggc agaagcctat agcgagattg gtatgaaagg ggaacgcaga agaggcaaag 3060
gccacgacgg actgtaccag ggactcagca ccgccaccaa ggacacctat gacgctcttc 3120
acatgcaggc cctgccgcct cggggaagcg gagctactaa cttcagcctg ctgaagcagg 3180
ctggagacgt ggaggagaac cctggaccta tgagcgagct gattaaggag aacatgcaca 3240
tgaagctgta catggagggc accgtggaca accatcactt caagtgcaca tccgagggcg 3300
aaggcaagcc ctacgagggc acccagacca tgagaatcaa ggtggtcgag ggcggccctc 3360
tccccttcgc cttcgacatc ctggctacta gcttcctcta cggcagcaag accttcatca 3420
accacaccca gggcatcccc gacttcttca agcagtcctt ccctgagggc ttcacatggg 3480
agagagtcac cacatacgaa gacgggggcg tgctgaccgc tacccaggac accagcctcc 3540
aggacggctg cctcatctac aacgtcaaga tcagaggggt gaacttcaca tccaacggcc 3600
ctgtgatgca gaagaaaaca ctcggctggg aggccttcac cgagacgctg taccccgctg 3660
acggcggcct ggaaggcaga aacgacatgg ccctgaagct cgtgggcggg agccatctga 3720
tcgcaaacat caagaccaca tatagatcca agaaacccgc taagaacctc aagatgcctg 3780
gcgtctacta tgtggactac agactggaaa gaatcaagga ggccaacaac gaaacatacg 3840
tcgagcagca cgaggtggca gtggccagat actgcgacct ccctagcaaa ctggggcaca 3900
agcttaatta a 3911

<210>  2
<211>  6
<212>  DNA
<213>  ˹
<400>  2
gccacc 6

<210>  3
<211>  608
<212>  DNA
<213>  ˹
<400>  3
cgcccctctc cctccccccc ccctaacgtt actggccgaa gccgcttgga ataaggccgg 60
tgtgcgtttg tctatatgtt attttccacc atattgccgt cttttggcaa tgtgagggcc 120
cggaaacctg gccctgtctt cttgacgagc attcctaggg gtctttcccc tctcgccaaa 180
ggaatgcaag gtctgttgaa tgtcgtgaag gaagcagttc ctctggaagc ttcttgaaga 240
caaacaacgt ctgtagcgac cctttgcagg cagcggaacc ccccacctgg cgacaggtgc 300
ctctgcggcc aaaagccacg tgtataagat acacctgcaa aggcggcaca accccagtgc 360
cacgttgtga gttggatagt tgtggaaaga gtcaaatggc tctcctcaag cgtattcaac 420
aaggggctga aggatgccca gaaggtaccc cattgtatgg gatctgatct ggggcctcgg 480
tgcacatgct ttacatgtgt ttagtcgagg ttaaaaaaac gtctaggccc cccgaaccac 540
ggggacgtgg ttttcctttg aaaaacacga tgataagctt gccacaaccc acaaggagac 600
gaccttcc 608

<210>  4
<211>  233
<212>  PRT
<213>  ˹
<400>  4
Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu
1            5                10               15
Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly
         20               25               30
Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly
       35               40              45
Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr
   50                55              60
Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe
65               70              75               80
Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr
             85               90               95
Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp
          100              105              110
Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
       115             120             125
Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr
    130             135              140
Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met
145             150               155               160
Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr
             165              170             175            
Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val
180             185               190         
Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu
195              200              205         
Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu
210             215             220         
Pro Ser Lys Leu Gly His Lys Leu Asn
225               230

<210>  5
<211>  19
<212>  PRT
<213>  ˹
<400>  5
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1             5                10               15
Pro Gly Pro

<210>  6
<211>  244
<212>  PRT
<213>  ˹
<400>  6
Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro
 1            5                10               15
Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr
          20              25               30
Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu
       35               40               45             
Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln
   50              55               60             
Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr
65               70               75               80
Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr
              85               90               95
Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly
          100              105               110  
Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
       115             120              125        
Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro
   130              135              140            
Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser
145             150              155              160
Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly
             165             170              175
Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly
         180             185               190    
Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu
      195              200              205        
Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln
   210            215               220              
Gln Trp Ser Lys His Pro Leu Thr Tyr Gly Ala Gly Thr Lys Leu Glu
225             230              235               240
Ile Lys Ser Ser

<210>  7
<211>  42
<212>  PRT
<213>  ˹
<400>  7
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met
1              5               10              15
Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe
          20               25                30 
Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu  
       35               40       

<210>  8
<211>  21
<212>  PRT
<213>  ˹
<400>  8
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1             5               10               15
His Ala Ala Arg Pro
          20

<210>  9
<211>  256
<212>  PRT
<213>  ˹
<400>  9
Ala Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser
1            5               10               15
Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val
           20              25              30
His Ser Asn Gly Asn Thr Tyr Leu Arg Trp Tyr Leu Gln Lys Pro Gly
       35               40               45
Gln Ser Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Val Ser Gly
    50              55              60              
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
65               70               75               80
Lys Ile Asn Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser
             85               90               95
Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu
          100             105               110
Ile Lys Ser Ser Ala Asp Asp Ala Lys Lys Asp Ala Ala Lys Lys Asp
      115             120              125                  
Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp Gly Gly Val Lys Leu Asp
   130              135               140               
Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ala Met Lys Leu Ser
145              150              155              160    
Cys Val Thr Ser Gly Phe Thr Phe Gly His Tyr Trp Met Asn Trp Val
             165              170              175   
Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala Gln Phe Arg Asn
          180              185              190   
Lys Pro Tyr Asn Tyr Glu Thr Tyr Tyr Ser Asp Ser Val Lys Gly Arg
      195              200              205  
Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln Met
   210             215              220   
Asn Asn Leu Arg Val Glu Asp Thr Gly Ile Tyr Tyr Cys Thr Gly Ala
225              230              235              240
Ser Tyr Gly Met Glu Tyr Leu Gly Gln Gly Thr Ser Val Thr Val Ser
             245               250             255

<210>  10
<211>  112
<212>  PRT
<213>  ˹
<400>  10
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly
1	5	10	15
Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr
           20   	25	30
Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys
       35   	40	45
Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys
   50                55   	         60
Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg
65                70 	75	80
Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala
              85                90	95
Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg
          100              105               110 

<210>  11
<211>  21
<212>  PRT
<213>  ˹
<400>  11
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
 1             5               10               15
His Ala Ala Arg Pro
          20

<210>  12
<211>  45 
<212>  PRT
<213>  ˹
<400>  12
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
 1            5               10               15
Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
          20               25               30               
Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp      
       35               40               45              

<210>  13
<211>  24
<212>  PRT
<213>  ˹
<400>  13
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1	5	10	15
Ser Leu Val Ile Thr Leu Tyr Cys
	20


