                         SEQUENCE LISTING

<110>  U.S. Army Medical Research & Materiel Command
 
<120>  TOBAMOVIRUS-BASED VIRUS-LIKE PARTICLES AND VACCINES

<130>  WRAIR 17-25_PCT (61883WO01)

<140>  tbd
<141>  2018-09-21

<150>  US 62/561,956
<151>  2017-09-22

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  Tobacco mosaic virus

<400>  1

Met Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser Ser 
1               5                   10                  15      


Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala Leu 
            20                  25                  30          


Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg Gln 
        35                  40                  45              


Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe Pro 
    50                  55                  60                  


Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro Leu 
65                  70                  75                  80  


Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn Arg Ile Ile Glu 
                85                  90                  95      


Val Glu Asn Gln Ala Asn Pro Thr Thr Ala Glu Thr Leu Asp Ala Thr 
            100                 105                 110         


Arg Arg Val Asp Asp Ala Thr Val Ala Ile Arg Ser Ala Ile Asn Asn 
        115                 120                 125             


Leu Ile Val Glu Leu Thr Arg Gly Thr Gly Ser Tyr Asn Arg Ser Ser 
    130                 135                 140                 


Phe Glu Ser Ser Ser Gly Leu Val Trp Thr Ser Ser Pro Ala Thr 
145                 150                 155                 


<210>  2
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Cys Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Ser Gly Pro Ala Gly Glu Gly Ser Tyr Ser Ile Thr Thr Pro 
    50                  55                  60                  


Ser Gln Phe Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu 
65                  70                  75                  80  


Ile Asn Leu Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln 
                85                  90                  95      


Ala Arg Thr Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser 
            100                 105                 110         


Pro Gln Val Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg 
        115                 120                 125             


Tyr Asn Ala Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe 
    130                 135                 140                 


Asp Thr Arg Asn 
145             


<210>  3
<211>  161
<212>  PRT
<213>  Zucchini mosaic virus

<400>  3

Met Pro Tyr Ser Thr Ser Gly Ile Arg Ser Leu Pro Ala Phe Ser Lys 
1               5                   10                  15      


Ser Phe Phe Pro Tyr Leu Glu Leu Tyr Asn Leu Leu Ile Thr Asn Gln 
            20                  25                  30          


Gly Ala Ala Leu Gln Thr Gln Asn Gly Lys Asp Ile Leu Arg Glu Ser 
        35                  40                  45              


Leu Val Gly Leu Leu Ser Ser Val Ala Ser Pro Thr Ser Gln Phe Pro 
    50                  55                  60                  


Ser Gly Val Phe Tyr Val Trp Ser Arg Glu Ser Arg Ile Ala Ala Leu 
65                  70                  75                  80  


Ile Asp Ser Leu Phe Gly Ala Leu Asp Ser Arg Asn Arg Ala Ile Glu 
                85                  90                  95      


Val Glu Asn Pro Ser Asn Pro Ser Thr Gly Glu Ala Leu Asn Ala Val 
            100                 105                 110         


Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro Gln 
        115                 120                 125             


Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala Ser 
    130                 135                 140                 


Phe Glu Ser Ala Phe Gly Leu Val Trp Thr Ala Gly Ser Ser Thr Ser 
145                 150                 155                 160 


Ser 
    


<210>  4
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met His His His His His His Lys Arg Asn Asp Asp Ala Ser Thr Ala 
1               5                   10                  15      


Ala His Asn Asp Ile Pro Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala 
            20                  25                  30          


Gly Val Phe Asp Arg Ala Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp 
        35                  40                  45              


Thr Gly Ser Ser Tyr Ser Thr Ser Gly Ile Arg Ser Leu Pro Ala Phe 
    50                  55                  60                  


Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr Asn Leu Leu Ile Thr 
65                  70                  75                  80  


Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly Lys Asp Ile Leu Arg 
                85                  90                  95      


Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala Ser Pro Thr Ser Gln 
            100                 105                 110         


Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg Glu Ser Arg Ile Ala 
        115                 120                 125             


Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp Gln Glu 
    130                 135                 140     


<210>  5
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Ser Tyr 
    50                  55                  60                  


Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser Ser Ala Trp Ala 
65                  70                  75                  80  


Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala Leu Gly Asn Gln 
                85                  90                  95      


Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg Gln Phe Ser Glu 
            100                 105                 110         


Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe Pro Asp Ser Asp 
        115                 120                 125             


Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro Leu Val Thr Ala 
    130                 135                 140                 


Leu Leu Gly Ala Phe Asp Thr Arg Asn 
145                 150             


<210>  6
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    50                  55                  60                  


Asn Ala Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser 
65                  70                  75                  80  


Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala 
                85                  90                  95      


Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg 
            100                 105                 110         


Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe 
        115                 120                 125             


Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro 
    130                 135                 140                 


Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn 
145                 150                 155         


<210>  7
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic

<400>  7

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    50                  55                  60                  


Asn Ala Asn Pro Asn Ala Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe 
65                  70                  75                  80  


Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu 
                85                  90                  95      


Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr 
            100                 105                 110         


Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val 
        115                 120                 125             


Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala 
    130                 135                 140                 


Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg 
145                 150                 155                 160 


Asn 
    


<210>  8
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
1               5                   10                  15      


Ala Asn Pro Asn Ala Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val 
            20                  25                  30          


Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys 
        35                  40                  45              


Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val 
    50                  55                  60                  


Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr 
65                  70                  75                  80  


Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val 
                85                  90                  95      


Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn 
            100                 105                 110         


His His His His His His His His Thr Arg Arg Val Asp Asp Ala Thr 
        115                 120                 125             


Val Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg 
    130                 135                 140                 


Gly Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu 
145                 150                 155                 160 


Val Trp Thr Ser Gly 
                165 


<210>  9
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser Ser 
1               5                   10                  15      


Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala Leu 
            20                  25                  30          


Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg Gln 
        35                  40                  45              


Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe Pro 
    50                  55                  60                  


Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro Leu 
65                  70                  75                  80  


Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn His His His His 
                85                  90                  95      


His His His His Thr Arg Arg Val Asp Asp Ala Thr Val Ala Ile Arg 
            100                 105                 110         


Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly Thr Gly Ser 
        115                 120                 125             


Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val Trp Thr Ser 
    130                 135                 140                 


Gly Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn 
145                 150                 155                 160 


Ala Asn Pro Asn Ala 
                165 


<210>  10
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    50                  55                  60                  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Ser Tyr 
65                  70                  75                  80  


Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser Ser Ala Trp Ala 
                85                  90                  95      


Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala Leu Gly Asn Gln 
            100                 105                 110         


Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg Gln Phe Ser Glu 
        115                 120                 125             


Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe Pro Asp Ser Asp 
    130                 135                 140                 


Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro Leu Val Thr Ala 
145                 150                 155                 160 


Leu Leu Gly Ala Phe Asp Thr Arg Asn 
                165                 


<210>  11
<211>  181
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    50                  55                  60                  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
65                  70                  75                  80  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Ser Tyr Ser Ile Thr Thr 
                85                  90                  95      


Pro Ser Gln Phe Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu 
            100                 105                 110         


Leu Ile Asn Leu Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln 
        115                 120                 125             


Gln Ala Arg Thr Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro 
    130                 135                 140                 


Ser Pro Gln Val Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr 
145                 150                 155                 160 


Arg Tyr Asn Ala Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala 
                165                 170                 175     


Phe Asp Thr Arg Asn 
            180     


<210>  12
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
    50                  55                  60                  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
65                  70                  75                  80  


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
                85                  90                  95      


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
            100                 105                 110         


Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro 
        115                 120                 125             


Asn Ala Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val Phe Leu Ser 
    130                 135                 140                 


Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys Thr Asn Ala 
145                 150                 155                 160 


Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val Val Gln Arg 
                165                 170                 175     


Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr Val Arg Phe 
            180                 185                 190         


Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val Leu Asp Pro 
        195                 200                 205             


Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn 
    210                 215                 220     


<210>  13

<400>  13
000

<210>  14
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Thr Asn Pro Asn Ala Asn 
        35                  40                  45              


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Ser 
    50                  55                  60                  


Tyr Ser Thr Ser Gly Ile Arg Ser Leu Pro Ala Phe Ser Lys Ser Phe 
65                  70                  75                  80  


Phe Pro Tyr Leu Glu Leu Tyr Asn Leu Leu Ile Thr Asn Gln Gly Ala 
                85                  90                  95      


Ala Leu Gln Thr Gln Asn Gly Lys Asp Ile Leu Arg Glu Ser Leu Val 
            100                 105                 110         


Gly Leu Leu Ser Ser Val Ala Ser Pro Thr Ser Gln Phe Pro Ser Gly 
        115                 120                 125             


Val Phe Tyr Val Trp Ser Arg Glu Ser Arg Ile Ala Ala Leu Ile Asp 
    130                 135                 140                 


Ser Leu Phe Gly Ala Leu Asp Ser Arg Asn 
145                 150                 


<210>  15
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Thr Asn Pro Asn Ala Asn 
        35                  40                  45              


Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala Asn 
    50                  55                  60                  


Pro Asn Ala Asn Pro Asn Ala Ser Tyr Ser Thr Ser Gly Ile Arg Ser 
65                  70                  75                  80  


Leu Pro Ala Phe Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr Asn 
                85                  90                  95      


Leu Leu Ile Thr Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly Lys 
            100                 105                 110         


Asp Ile Leu Arg Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala Ser 
        115                 120                 125             


Pro Thr Ser Gln Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg Glu 
    130                 135                 140                 


Ser Arg Ile Ala Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp Ser 
145                 150                 155                 160 


Arg Asn 
        


<210>  16
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Thr Met Lys Glu Ile Glu 
        35                  40                  45              


Arg Glu Ser Lys Arg Ile Lys Leu Asn Asp Asn Asp Asp Glu Gly Asn 
    50                  55                  60                  


Lys Lys Ile Ile Ala Ser Tyr Ser Thr Ser Gly Ile Arg Ser Leu Pro 
65                  70                  75                  80  


Ala Phe Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr Asn Leu Leu 
                85                  90                  95      


Ile Thr Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly Lys Asp Ile 
            100                 105                 110         


Leu Arg Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala Ser Pro Thr 
        115                 120                 125             


Ser Gln Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg Glu Ser Arg 
    130                 135                 140                 


Ile Ala Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp Ser Arg Asn 
145                 150                 155                 160 


<210>  17
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Ser Asp Gln Pro Lys Gln 
        35                  40                  45              


Tyr Glu Gln His Leu Thr Asp Tyr Glu Lys Ile Lys Glu Gly Phe Lys 
    50                  55                  60                  


Asn Lys Asn Ala Ser Met Ile Lys Ser Ala Phe Leu Pro Thr Gly Ala 
65                  70                  75                  80  


Phe Lys Ala Asp Arg Tyr Gly Ser Tyr Ser Thr Ser Gly Ile Arg Ser 
                85                  90                  95      


Leu Pro Ala Phe Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr Asn 
            100                 105                 110         


Leu Leu Ile Thr Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly Lys 
        115                 120                 125             


Asp Ile Leu Arg Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala Ser 
    130                 135                 140                 


Pro Thr Ser Gln Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg Glu 
145                 150                 155                 160 


Ser Arg Ile Ala Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp Ser 
                165                 170                 175     


Arg Asn 
        


<210>  18
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Thr Gly Ile Pro Asp Asn 
        35                  40                  45              


Asp Lys Asn Ser Asn Ser Lys Gly Ser Tyr Ser Thr Ser Gly Ile Arg 
    50                  55                  60                  


Ser Leu Pro Ala Phe Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr 
65                  70                  75                  80  


Asn Leu Leu Ile Thr Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly 
                85                  90                  95      


Lys Asp Ile Leu Arg Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala 
            100                 105                 110         


Ser Pro Thr Ser Gln Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg 
        115                 120                 125             


Glu Ser Arg Ile Ala Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp 
    130                 135                 140                 


Ser Arg Asn 
145         


<210>  19
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Ser Asp Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    50                  55                  60                  


Asn Pro Asn Ala Asn Pro Asn Ala Glu Gly Ser Tyr Ser Ile Thr Thr 
65                  70                  75                  80  


Pro Ser Gln Phe Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu 
                85                  90                  95      


Leu Ile Asn Leu Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln 
            100                 105                 110         


Gln Ala Arg Thr Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro 
        115                 120                 125             


Ser Pro Gln Val Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr 
    130                 135                 140                 


Arg Tyr Asn Ala Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala 
145                 150                 155                 160 


Phe Asp Thr Arg Asn 
                165 


<210>  20
<211>  167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met His His His His His His Asp Ala Thr Arg Arg Val Asp Asp Ala 
1               5                   10                  15      


Thr Val Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile 
            20                  25                  30          


Arg Gly Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly 
        35                  40                  45              


Leu Val Trp Thr Asn Pro Asn Ala Asn Pro Asn Ala Asn Pro Asn Ala 
    50                  55                  60                  


Asn Pro Asn Ala Asn Pro Asn Ala Ser Tyr Ser Ile Thr Thr Pro Ser 
65                  70                  75                  80  


Gln Phe Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile 
                85                  90                  95      


Asn Leu Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala 
            100                 105                 110         


Arg Thr Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser Pro 
        115                 120                 125             


Gln Val Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr 
    130                 135                 140                 


Asn Ala Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe Asp 
145                 150                 155                 160 


Thr Arg Asn Arg Ile Ile Glu 
                165         


<210>  21
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X at position 53 denotes placeholder for location of insertion of
       immunogenic epitopes of interest.

<400>  21

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Ser Asp Xaa Glu Gly Ser Tyr Ser Ile Thr Thr Pro Ser Gln 
    50                  55                  60                  


Phe Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn 
65                  70                  75                  80  


Leu Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg 
                85                  90                  95      


Thr Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln 
            100                 105                 110         


Val Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn 
        115                 120                 125             


Ala Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr 
    130                 135                 140                 


Arg Asn 
145     


<210>  22
<211>  148
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_features
<222>  (53)..(53)
<223>  X at position 53 denotes placeholder for location of insertion of
       immunogenic epitopes of interest.

<400>  22

Met His His His His His His Asp Ala Thr Arg Arg Val Asp Asp Ala 
1               5                   10                  15      


Thr Val Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile 
            20                  25                  30          


Arg Gly Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly 
        35                  40                  45              


Leu Val Trp Thr Xaa Ser Tyr Ser Ile Thr Thr Pro Ser Gln Phe Val 
    50                  55                  60                  


Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn Leu Cys 
65                  70                  75                  80  


Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg Thr Val 
                85                  90                  95      


Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln Val Thr 
            100                 105                 110         


Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn Ala Val 
        115                 120                 125             


Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr Arg Asn 
    130                 135                 140                 


Arg Ile Ile Glu 
145             


<210>  23
<211>  179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Thr Gly Asp Arg Ala Asp 
        35                  40                  45              


Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly Asp Arg 
    50                  55                  60                  


Ala Asp Gly Gln Pro Ala Gly Asp Arg Ala Ala Gly Gln Pro Ala Gly 
65                  70                  75                  80  


Asp Arg Ala Asp Gly Gln Pro Ala Ser Tyr Ser Thr Ser Gly Ile Arg 
                85                  90                  95      


Ser Leu Pro Ala Phe Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr 
            100                 105                 110         


Asn Leu Leu Ile Thr Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly 
        115                 120                 125             


Lys Asp Ile Leu Arg Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala 
    130                 135                 140                 


Ser Pro Thr Ser Gln Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg 
145                 150                 155                 160 


Glu Ser Arg Ile Ala Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp 
                165                 170                 175     


Ser Arg Asn 
            


<210>  24
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Lys Arg Asn Asp Asp Ala Ser Thr Ala Ala His Asn Asp Ile Pro 
1               5                   10                  15      


Gln Ile Leu Ser Ala Leu Asn Glu Gly Ala Gly Val Phe Asp Arg Ala 
            20                  25                  30          


Ser Phe Glu Ser Ala Phe Gly Leu Thr Trp Thr Gly Asn Gln Pro Gly 
        35                  40                  45              


Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln 
    50                  55                  60                  


Pro Gly Ala Asn Gly Ser Tyr Ser Thr Ser Gly Ile Arg Ser Leu Pro 
65                  70                  75                  80  


Ala Phe Ser Lys Ser Phe Phe Pro Tyr Leu Glu Leu Tyr Asn Leu Leu 
                85                  90                  95      


Ile Thr Asn Gln Gly Ala Ala Leu Gln Thr Gln Asn Gly Lys Asp Ile 
            100                 105                 110         


Leu Arg Glu Ser Leu Val Gly Leu Leu Ser Ser Val Ala Ser Pro Thr 
        115                 120                 125             


Ser Gln Phe Pro Ser Gly Val Phe Tyr Val Trp Ser Arg Glu Ser Arg 
    130                 135                 140                 


Ile Ala Ala Leu Ile Asp Ser Leu Phe Gly Ala Leu Asp Ser Arg Asn 
145                 150                 155                 160 


<210>  25
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met His His His His His His Thr Arg Arg Val Asp Asp Ala Thr Val 
1               5                   10                  15      


Ala Ile Arg Ser Ala Ile Asn Asn Leu Ile Val Glu Leu Ile Arg Gly 
            20                  25                  30          


Thr Gly Ser Tyr Asn Arg Ser Ser Phe Glu Ser Ser Ser Gly Leu Val 
        35                  40                  45              


Trp Thr Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asp Gln Pro Gly 
    50                  55                  60                  


Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly Asn Gln 
65                  70                  75                  80  


Pro Gly Ala Asn Gly Ala Gly Asn Gln Pro Gly Ala Asn Gly Ala Gly 
                85                  90                  95      


Asn Gln Pro Gly Ala Asn Gly Ser Tyr Ser Ile Thr Thr Pro Ser Gln 
            100                 105                 110         


Phe Val Phe Leu Ser Ser Ala Trp Ala Asp Pro Ile Glu Leu Ile Asn 
        115                 120                 125             


Leu Cys Thr Asn Ala Leu Gly Asn Gln Phe Gln Thr Gln Gln Ala Arg 
    130                 135                 140                 


Thr Val Val Gln Arg Gln Phe Ser Glu Val Trp Lys Pro Ser Pro Gln 
145                 150                 155                 160 


Val Thr Val Arg Phe Pro Asp Ser Asp Phe Lys Val Tyr Arg Tyr Asn 
                165                 170                 175     


Ala Val Leu Asp Pro Leu Val Thr Ala Leu Leu Gly Ala Phe Asp Thr 
            180                 185                 190         


Arg Asn 
        


