                         SEQUENCE LISTING

<110>  Wayne State University
 
<120>  SYSTEMS AND METHODS TO DETECT STRESS LEADING TO MISCARRIAGE RISK

<130>  W063-0047PCT

<150>  US 62/561,761
<151>  2017-09-22

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Tyr Tyr Arg Lys Tyr Ala Ala Ile Phe Leu Val Thr Leu Ser 
1               5                   10                  15      


Val Phe Leu His Val Leu His Ser Ala Pro Asp Val Gln Asp Cys Pro 
            20                  25                  30          


Glu Cys Thr Leu Gln Glu Asn Pro Phe Phe Ser Gln Pro Gly Ala Pro 
        35                  40                  45              


Ile Leu Gln Cys Met Gly Cys Cys Phe Ser Arg Ala Tyr Pro Thr Pro 
    50                  55                  60                  


Leu Arg Ser Lys Lys Thr Met Leu Val Gln Lys Asn Val Thr Ser Glu 
65                  70                  75                  80  


Ser Thr Cys Cys Val Ala Lys Ser Tyr Asn Arg Val Thr Val Met Gly 
                85                  90                  95      


Gly Phe Lys Val Glu Asn His Thr Ala Cys His Cys Ser Thr Cys Tyr 
            100                 105                 110         


Tyr His Lys Ser 
        115     


<210>  2
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Met Phe Gln Gly Leu Leu Leu Leu Leu Leu Leu Ser Met Gly 
1               5                   10                  15      


Gly Thr Trp Ala Ser Lys Glu Pro Leu Arg Pro Arg Cys Arg Pro Ile 
            20                  25                  30          


Asn Ala Thr Leu Ala Val Glu Lys Glu Gly Cys Pro Val Cys Ile Thr 
        35                  40                  45              


Val Asn Thr Thr Ile Cys Ala Gly Tyr Cys Pro Thr Met Thr Arg Val 
    50                  55                  60                  


Leu Gln Gly Val Leu Pro Ala Leu Pro Gln Val Val Cys Asn Tyr Arg 
65                  70                  75                  80  


Asp Val Arg Phe Glu Ser Ile Arg Leu Pro Gly Cys Pro Arg Gly Val 
                85                  90                  95      


Asn Pro Val Val Ser Tyr Ala Val Ala Leu Ser Cys Gln Cys Ala Leu 
            100                 105                 110         


Cys Arg Arg Ser Thr Thr Asp Cys Gly Gly Pro Lys Asp His Pro Leu 
        115                 120                 125             


Thr Cys Asp Asp Pro Arg Phe Gln Asp Ser Ser Ser Ser Lys Ala Pro 
    130                 135                 140                 


Pro Pro Ser Leu Pro Ser Pro Ser Arg Leu Pro Gly Pro Ser Asp Thr 
145                 150                 155                 160 


Pro Ile Leu Pro Gln 
                165 


<210>  3
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gln Leu Thr Leu Asn Leu Ser Gly Ser Ala Gly Met Gln Leu Leu 
1               5                   10                  15      


Leu Leu Val Ser Ser Leu Leu Leu Trp Glu Asn Val Ser Ser Lys Pro 
            20                  25                  30          


Thr Ala Met Val Pro Thr Glu Asp Leu Tyr Thr Arg Leu Ala Glu Leu 
        35                  40                  45              


Leu His Asn Thr Phe Ile Leu Ala Ala Asp Val Tyr Arg Glu Phe Asp 
    50                  55                  60                  


Leu Asp Phe Phe Asp Lys Thr Trp Ile Thr Asp Arg Thr Leu Pro Leu 
65                  70                  75                  80  


Cys His Thr Ala Ser Ile His Thr Pro Glu Asn Arg Glu Glu Val His 
                85                  90                  95      


Glu Thr Lys Thr Glu Asp Leu Leu Lys Ala Met Ile Asn Val Ser Ile 
            100                 105                 110         


Ser Trp Lys Glu Pro Leu Lys His Leu Val Ser Ala Leu Thr Ala Leu 
        115                 120                 125             


Pro Gly Ala Ser Glu Ser Met Gly Lys Lys Ala Ala Asp Ile Lys Gly 
    130                 135                 140                 


Arg Asn Leu Val Ile Leu Glu Gly Leu Gln Thr Ile Tyr Asn Arg Ser 
145                 150                 155                 160 


Gln Ala Asn Ile Glu Glu Asn Glu Asn Phe Asp Tyr Pro Ala Trp Ser 
                165                 170                 175     


Gly Leu Glu Glu Leu Gln Ser Pro Asn Glu Asp Thr His Leu Phe Ala 
            180                 185                 190         


Val Tyr Asn Leu Cys Arg Cys Ile Lys Arg Asp Ile His Lys Ile Asp 
        195                 200                 205             


Ser Tyr Ile Lys Val Leu Arg Cys Arg Val Val Phe Gln Asn Glu Cys 
    210                 215                 220                 


<210>  4
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  4

Met Gln Leu Thr Leu Thr Leu Ser Gly Ser Ala Gly Met Gln Leu Leu 
1               5                   10                  15      


Leu Leu Val Ser Ser Leu Leu Leu Trp Glu Asn Val Ser Ser Lys Pro 
            20                  25                  30          


Thr Ala Met Val Pro Thr Asp Asp Leu Tyr Thr Arg Leu Ala Glu Leu 
        35                  40                  45              


Ser His Asn Thr Phe Ile Leu Ala Ala Asp Val Tyr Arg Glu Phe Asp 
    50                  55                  60                  


Leu Asp Phe Phe Asp Lys Thr Trp Ile Thr Asp Arg Thr Leu Pro Leu 
65                  70                  75                  80  


Cys His Thr Ala Ser Ile His Thr Pro Glu Asn Arg Glu Glu Val His 
                85                  90                  95      


Glu Ile Lys Thr Glu Asp Leu Leu Lys Ala Met Ile Asn Val Ser Ile 
            100                 105                 110         


Ser Trp Lys Glu Pro Leu Lys His Leu Val Ser Ala Leu Thr Ala Leu 
        115                 120                 125             


Pro Gly Ala Ser Glu Ser Met Gly Lys Lys Ala Ala Asp Ile Lys Gly 
    130                 135                 140                 


Arg Asn Leu Ile Ile Leu Glu Gly Leu Gln Thr Ile Tyr Asn Arg Thr 
145                 150                 155                 160 


Gln Ala Asn Ile Glu Glu Asn Glu Asn Phe Asp Tyr Pro Ala Trp Thr 
                165                 170                 175     


Gly Leu Glu Glu Leu Gln Ser Pro Asn Glu Asp Thr His Leu Phe Ala 
            180                 185                 190         


Val Tyr Asn Leu Cys Arg Cys Ile Lys Arg Asp Ile His Lys Ile Asp 
        195                 200                 205             


Ser Tyr Ile Lys Val Leu Arg Cys Arg Val Val Phe Gln Asn Glu Cys 
    210                 215                 220                 


<210>  5
<211>  223
<212>  PRT
<213>  Mus musculus

<400>  5

Met Gln Leu Thr Leu Thr Leu Ser Gly Ser Gly Met Gln Leu Leu Leu 
1               5                   10                  15      


Leu Val Ser Ser Leu Phe Leu Trp Glu Asn Val Ser Ser Lys Pro Thr 
            20                  25                  30          


Ala Met Val Pro Thr Glu Asp Leu Tyr Thr Arg Leu Ala Glu Leu Ser 
        35                  40                  45              


His Ser Thr Phe Ile Leu Ala Ala Asp Val Tyr Arg Glu Phe Asp Leu 
    50                  55                  60                  


Asp Phe Phe Asp Lys Thr Trp Ile Thr Asp Arg Thr Leu Pro Leu Cys 
65                  70                  75                  80  


His Thr Ala Ser Ile His Thr Pro Glu Asn Arg Glu Glu Val His Glu 
                85                  90                  95      


Ile Lys Thr Glu Asp Leu Leu Lys Ala Met Ile Asn Val Ser Ile Ser 
            100                 105                 110         


Trp Lys Glu Pro Leu Lys His Leu Val Ser Ala Leu Thr Ala Leu Pro 
        115                 120                 125             


Gly Ala Ser Glu Ser Met Gly Lys Lys Ala Ala Asp Ile Lys Gly Arg 
    130                 135                 140                 


Asn Leu Ile Ile Leu Glu Gly Leu Gln Thr Ile Tyr Asn Arg Thr Gln 
145                 150                 155                 160 


Ala Asn Ile Glu Glu Asn Glu Asn Phe Asp Tyr Pro Ala Trp Ser Gly 
                165                 170                 175     


Leu Glu Glu Leu Gln Ser Pro Asn Glu Asp Thr His Leu Phe Ala Val 
            180                 185                 190         


Tyr Asn Leu Cys Arg Cys Ile Lys Arg Asp Ile His Lys Ile Asp Ser 
        195                 200                 205             


Tyr Ile Lys Val Leu Arg Cys Arg Val Val Phe Gln Asn Glu Cys 
    210                 215                 220             


<210>  6
<211>  351
<212>  DNA
<213>  Homo Sapiens

<400>  6
atggattact acagaaaata tgcagctatc tttctggtca cattgtcggt gtttctgcat       60

gttctccatt ccgctcctga tgtgcaggat tgcccagaat gcacgctaca ggaaaaccca      120

ttcttctccc agccgggtgc cccaatactt cagtgcatgg gctgctgctt ctctagagca      180

tatcccactc cactaaggtc caagaagacg atgttggtcc aaaagaacgt cacctcagag      240

tccacttgct gtgtagctaa atcatataac agggtcacag taatgggggg tttcaaagtg      300

gagaaccaca cggcgtgcca ctgcagtact tgttattatc acaaatctta a               351


<210>  7
<211>  498
<212>  DNA
<213>  homo sapiens

<400>  7
atggagatgt tccaggggct gctgctgttg ctgctgctga gcatgggcgg gacatgggca       60

tccagggaga tgcttcggcc acggtgccgc cccatcaatg ccaccctggc tgtggagaag      120

gagggctgcc ccgtgtgcat caccgtcaac accaccatct gtgccggcta ctgccccacc      180

atgacccgcg tgctgcaggg ggtcctgccg gccctgcctc aggtggtgtg caactaccgc      240

gatgtgcgct tcgagtccat ccggctccct ggctgcccgc gcggcgtgaa ccccgtggtc      300

tcctacgccg tggctctcag ctgtcaatgt gcactctgcc gccgcagcac cactgactgc      360

gggggtccca aggaccaccc cttgacctgt gatgaccccc gcttccaggc ctcctcttcc      420

tcaaaggccc ctccccccag ccttccaagt ccatcccgac tcccggggcc ctcagacacc      480

ccgatcctcc cacaataa                                                    498


<210>  8
<211>  844
<212>  DNA
<213>  Mus musculus

<400>  8
ttcctcactt ggagcctaca ttgtggtgga tcttctcaga aatgcagctg actttgaatc       60

tttcaggctc cgcaggaatg caattgttgc tgctggtgtc aagcctactc ctttgggaga      120

atgtgtcctc caaaccaact gccatggtgc ccactgaaga cctgtatact cgtttggctg      180

aactgctcca taatacattt atcttggccg cagatgtgta tagggaattt gatttggatt      240

ttttcgataa aacttggata acagacagaa cacttcccct gtgtcatact gcttccatcc      300

atactccaga gaatcgagag gaagtccacg aaactaaaac tgaagacctt ctgaaagcaa      360

tgatcaatgt ttcaatttcc tggaaagaac ctctgaaaca cctggtgtct gcactgacgg      420

ctctcccagg agcttctgag agtatgggga aaaaagctgc tgacattaag ggcagaaacc      480

ttgtaattct ggagggactt cagacaatat acaacaggtc tcaggctaac attgaagaaa      540

atgaaaattt tgactaccct gcttggtctg gactcgaaga actgcagtca cctaacgaag      600

acactcatct ttttgccgtt tataatctat gccgctgcat taaaagggac atccataaga      660

tagacagcta tatcaaagtc ttgaggtgcc gagttgtctt tcagaacgaa tgttgagtgc      720

ccacccagcg aagccctgcc cacatggtct ttgttgaacc agacttgtaa tgctttcccc      780

tcctcagtta tgatgagcta taatggaatt attgtcataa aataaaataa aattatttag      840

attc                                                                   844


