                         SEQUENCE LISTING

<110>  Modern Meadow. Inc.
 
<120>  Recombinant Yeast Strains

<130>  515907US

<150>  US 62/562,109
<151>  2017-09-22

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: kgtP gene, AKG transporter from E. coli

<400>  1

Met Ala Glu Ser Thr Val Thr Ala Asp Ser Lys Leu Thr Ser Ser Asp 
1               5                   10                  15      


Thr Arg Arg Arg Ile Trp Ala Ile Val Gly Ala Ser Ser Gly Asn Leu 
            20                  25                  30          


Val Glu Trp Phe Asp Phe Tyr Val Tyr Ser Phe Cys Ser Leu Tyr Phe 
        35                  40                  45              


Ala His Ile Phe Phe Pro Ser Gly Asn Thr Thr Thr Gln Leu Leu Gln 
    50                  55                  60                  


Thr Ala Gly Val Phe Ala Ala Gly Phe Leu Met Arg Pro Ile Gly Gly 
65                  70                  75                  80  


Trp Leu Phe Gly Arg Ile Ala Asp Lys His Gly Arg Lys Lys Ser Met 
                85                  90                  95      


Leu Leu Ser Val Cys Met Met Cys Phe Gly Ser Leu Val Ile Ala Cys 
            100                 105                 110         


Leu Pro Gly Tyr Glu Thr Ile Gly Thr Trp Ala Pro Ala Leu Leu Leu 
        115                 120                 125             


Leu Ala Arg Leu Phe Gln Gly Leu Ser Val Gly Gly Glu Tyr Gly Thr 
    130                 135                 140                 


Ser Ala Thr Tyr Met Ser Glu Val Ala Val Glu Gly Arg Lys Gly Phe 
145                 150                 155                 160 


Tyr Ala Ser Phe Gln Tyr Val Thr Leu Ile Gly Gly Gln Leu Leu Ala 
                165                 170                 175     


Leu Leu Val Val Val Val Leu Gln His Thr Met Glu Asp Ala Ala Leu 
            180                 185                 190         


Arg Glu Trp Gly Trp Arg Ile Pro Phe Ala Leu Gly Ala Val Leu Ala 
        195                 200                 205             


Val Val Ala Leu Trp Leu Arg Arg Gln Leu Asp Glu Thr Ser Gln Gln 
    210                 215                 220                 


Glu Thr Arg Ala Leu Lys Glu Ala Gly Ser Leu Lys Gly Leu Trp Arg 
225                 230                 235                 240 


Asn Arg Arg Ala Phe Ile Met Val Leu Gly Phe Thr Ala Ala Gly Ser 
                245                 250                 255     


Leu Cys Phe Tyr Thr Phe Thr Thr Tyr Met Gln Lys Tyr Leu Val Asn 
            260                 265                 270         


Thr Ala Gly Met His Ala Asn Val Ala Ser Gly Ile Met Thr Ala Ala 
        275                 280                 285             


Leu Phe Val Phe Met Leu Ile Gln Pro Leu Ile Gly Ala Leu Ser Asp 
    290                 295                 300                 


Lys Ile Gly Arg Arg Thr Ser Met Leu Cys Phe Gly Ser Leu Ala Ala 
305                 310                 315                 320 


Ile Phe Thr Val Pro Ile Leu Ser Ala Leu Gln Asn Val Ser Ser Pro 
                325                 330                 335     


Tyr Ala Ala Phe Gly Leu Val Met Cys Ala Leu Leu Ile Val Ser Phe 
            340                 345                 350         


Tyr Thr Ser Ile Ser Gly Ile Leu Lys Ala Glu Met Phe Pro Ala Gln 
        355                 360                 365             


Val Arg Ala Leu Gly Val Gly Leu Ser Tyr Ala Val Ala Asn Ala Ile 
    370                 375                 380                 


Phe Gly Gly Ser Ala Glu Tyr Val Ala Leu Ser Leu Lys Ser Ile Gly 
385                 390                 395                 400 


Met Glu Thr Ala Phe Phe Trp Tyr Val Thr Leu Met Ala Val Val Ala 
                405                 410                 415     


Phe Leu Val Ser Leu Met Leu His Arg Lys Gly Lys Gly Met Arg Leu 
            420                 425                 430         


<210>  2
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: kgtP gene, AKG transporter from E. coli, 
       native (unoptimized)

<400>  2
atggctgaaa gtactgtaac ggcagacagc aaactgacaa gtagtgatac tcgtcgccgc       60

atttgggcga ttgtgggggc ctcttcaggt aatctggtcg agtggttcga tttctatgtc      120

tactcgttct gttcactcta ctttgcccac atcttcttcc cttccgggaa cacgacgact      180

caactactac aaacagcagg tgtttttgct gcgggattcc tgatgcgccc aataggcggt      240

tggctatttg gccgcatagc cgataaacat ggtcgcaaaa aatcgatgct gttatcggtg      300

tgtatgatgt gtttcggatc gctggttatc gcctgcctcc caggttatga aactataggt      360

acgtgggctc cggcattatt gcttctcgct cgtttatttc agggattatc tgttggcgga      420

gaatatggca ccagcgccac ctatatgagt gaagttgccg ttgaagggcg caaaggtttt      480

tacgcatcat ttcagtatgt gacgttgatc ggcggacaac tgctagccct actggttgtc      540

gtggttttac aacacaccat ggaagacgct gcactcagag agtggggatg gcgtattcct      600

ttcgcgttag gagctgtgtt agctgttgtg gcgttgtggt tacgtcgtca gttagatgaa      660

acttcgcaac aagaaacgcg cgctttaaaa gaagctggat ctctgaaagg attatggcgc      720

aatcgccgtg cattcatcat ggttctcggt tttaccgctg cgggctccct ttgtttctat      780

accttcacta cttatatgca gaagtatctg gtaaatactg cgggaatgca tgccaacgtg      840

gcgagtggca ttatgactgc cgcattgttt gtattcatgc ttattcaacc actcattggc      900

gcgctgtcgg ataagattgg tcgccgtacc tcaatgttat gtttcggttc gctggcagcc      960

atttttaccg ttcctattct ctcagcattg caaaacgttt cctcgcctta tgccgctttt     1020

ggtctggtga tgtgtgccct gctgatagtg agtttttata catcaatcag tggaatactg     1080

aaggctgaga tgttcccggc acaggttcgc gcattaggcg ttggtctgtc atatgcggtc     1140

gctaatgcta tatttggtgg ttcggcggag tacgtagcgt tgtcgctgaa atcaatagga     1200

atggaaacag ccttcttctg gtatgtgacc ttgatggccg tggtggcgtt tctggtttct     1260

ttgatgctac atcgcaaagg gaaggggatg cgtctttag                            1299


<210>  3
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: kgtP gene, AKG transporter from E. coli, 
       codon optimized for Pichia

<400>  3
atggcagaat caactgtgac ggcagacagt aagctgacct catcagatac tagaaggaga       60

atctgggcaa tagttggagc ctcttccgga aatcttgtag agtggtttga cttttatgtt      120

tattcattct gcagtctgta ttttgcacat attttctttc catctggcaa caccaccaca      180

caactgttac agaccgccgg cgtgttcgct gccggatttc ttatgaggcc cattggtgga      240

tggttgtttg gtagaatagc tgacaagcat ggtcgtaaga agtctatgtt gttgtctgtc      300

tgtatgatgt gcttcggatc actggtaatt gcatgtcttc caggttacga gaccattgga      360

acatgggctc ccgctttgct tctacttgcc aggctatttc agggtttatc agtcggtggc      420

gaatacggca cttctgcaac gtacatgtct gaggtagcag tcgagggtag aaaaggattc      480

tacgcctcct ttcaatacgt tacactgata ggaggtcaac ttcttgcctt gctagtggtc      540

gttgtcctac aacacacgat ggaggacgct gctctgaggg aatggggatg gcgtataccc      600

ttcgctttag gtgccgtcct ggccgttgtc gcattgtggt tgaggaggca gctagatgaa      660

acttcccagc aagagacaag agcattgaaa gaggccggtt cacttaaagg tctgtggcgt      720

aaccgtcgtg cctttattat ggtgcttggc ttcacggctg ctggctccct ttgcttctat      780

actttcacca cttatatgca gaaatatttg gtgaatactg caggtatgca cgctaacgtc      840

gcttccggaa ttatgacggc tgcattgttt gtctttatgc taattcaacc attgataggc      900

gctctatctg ataagatagg ccgtaggact tcaatgctat gtttcggctc cttggctgca      960

atttttaccg tgcctattct atctgcccta caaaatgtgt cttctccata cgctgctttt     1020

ggtctggtaa tgtgcgcttt actaattgtg tctttttaca cgtcaatttc cggaatacta     1080

aaagccgaga tgttccccgc ccaggtacgt gccttaggtg ttggcctttc ttacgcagtc     1140

gcaaacgcta ttttcggtgg aagtgccgag tatgtagctt tgtctcttaa aagtatcgga     1200

atggagacgg cctttttctg gtatgtaact ttgatggccg tcgttgcatt cctagtttcc     1260

cttatgttac acaggaaagg caaaggtatg aggttataa                            1299


<210>  4
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: prolyl 3-hydroxylase 1 precursor (Bos taurus),
       NCBI reference sequence NP_001096761.1

<400>  4

Met Ala Ala Arg Ala Leu Arg Leu Leu Thr Ile Leu Leu Ala Val Ala 
1               5                   10                  15      


Ala Thr Ala Ser Gln Ala Glu Ala Glu Ser Glu Ala Gly Trp Asp Leu 
            20                  25                  30          


Thr Ala Pro Asp Leu Leu Phe Ala Glu Gly Thr Ala Ala Tyr Ala Arg 
        35                  40                  45              


Gly Asp Trp Ala Gly Val Val Leu Ser Met Glu Arg Ala Leu Arg Ser 
    50                  55                  60                  


Arg Ala Ala Leu Arg Ala Leu Arg Leu Arg Cys Arg Thr Arg Cys Ala 
65                  70                  75                  80  


Ala Asp Leu Pro Trp Glu Val Asp Pro Asp Ser Pro Pro Ser Leu Ala 
                85                  90                  95      


Gln Ala Ser Gly Ala Ser Ala Leu His Asp Leu Arg Phe Phe Gly Gly 
            100                 105                 110         


Leu Leu Arg Arg Ala Ala Cys Leu Arg Arg Cys Leu Gly Pro Ser Thr 
        115                 120                 125             


Ala His Ser Leu Ser Glu Glu Leu Glu Leu Glu Phe Arg Lys Arg Ser 
    130                 135                 140                 


Pro Tyr Asn Tyr Leu Gln Val Ala Tyr Phe Lys Ile Asn Lys Leu Glu 
145                 150                 155                 160 


Lys Ala Val Ala Ala Ala His Thr Phe Phe Val Gly Asn Pro Glu His 
                165                 170                 175     


Met Glu Met Arg Gln Asn Leu Asp Tyr Tyr Gln Thr Met Ser Gly Val 
            180                 185                 190         


Lys Glu Ala Asp Phe Lys Asp Leu Glu Ala Lys Pro His Met His Glu 
        195                 200                 205             


Phe Arg Leu Gly Val Arg Leu Tyr Ser Glu Glu Gln Pro Gln Glu Ala 
    210                 215                 220                 


Val Pro His Leu Glu Ala Ala Leu Arg Glu Tyr Phe Val Ala Ala Glu 
225                 230                 235                 240 


Glu Cys Arg Ala Leu Cys Glu Gly Pro Tyr Asp Tyr Asp Gly Tyr Asn 
                245                 250                 255     


Tyr Leu Glu Tyr Asn Ala Asp Leu Phe Gln Ala Ile Thr Asp His Tyr 
            260                 265                 270         


Ile Gln Val Leu Ser Cys Lys Gln Asn Cys Val Thr Glu Leu Ala Ser 
        275                 280                 285             


His Pro Ser Arg Glu Lys Pro Phe Glu Asp Phe Leu Pro Ser His Tyr 
    290                 295                 300                 


Asn Tyr Leu Gln Phe Ala Tyr Tyr Asn Ile Gly Asn Tyr Thr Gln Ala 
305                 310                 315                 320 


Ile Glu Cys Ala Lys Thr Tyr Leu Leu Phe Phe Pro Asn Asp Glu Val 
                325                 330                 335     


Met Ser Gln Asn Leu Ala Tyr Tyr Thr Ala Met Leu Gly Glu Glu Gln 
            340                 345                 350         


Ala Arg Ser Ile Gly Pro Arg Glu Ser Ala Gln Glu Tyr Arg Gln Arg 
        355                 360                 365             


Ser Leu Leu Glu Lys Glu Leu Leu Phe Phe Ala Tyr Asp Val Phe Gly 
    370                 375                 380                 


Ile Pro Phe Val Asp Pro Asp Ser Trp Thr Pro Val Glu Val Ile Pro 
385                 390                 395                 400 


Lys Arg Leu Gln Glu Lys Gln Lys Ser Glu Arg Glu Thr Ala Ala Arg 
                405                 410                 415     


Ile Ser Gln Glu Ile Gly Asn Leu Met Lys Glu Ile Glu Thr Leu Val 
            420                 425                 430         


Glu Glu Lys Thr Lys Glu Ser Leu Asp Val Ser Arg Leu Thr Arg Glu 
        435                 440                 445             


Gly Gly Pro Leu Leu Tyr Asp Gly Ile Arg Leu Thr Met Asn Ser Lys 
    450                 455                 460                 


Val Leu Asn Gly Ser Gln Arg Val Val Met Asp Gly Val Ile Ser Asp 
465                 470                 475                 480 


Glu Glu Cys Gln Glu Leu Gln Arg Leu Thr Asn Ala Ala Ala Thr Ser 
                485                 490                 495     


Gly Asp Gly Tyr Arg Gly Gln Thr Ser Pro His Thr Pro Ser Glu Lys 
            500                 505                 510         


Phe Tyr Gly Val Thr Val Phe Lys Ala Leu Lys Leu Gly Gln Glu Gly 
        515                 520                 525             


Lys Val Pro Leu Gln Ser Ala His Leu Tyr Tyr Asn Val Thr Glu Lys 
    530                 535                 540                 


Val Arg Arg Val Met Glu Ser Tyr Phe Arg Leu Asp Thr Pro Leu Tyr 
545                 550                 555                 560 


Phe Ser Tyr Ser His Leu Val Cys Arg Thr Ala Ile Glu Glu Ala Gln 
                565                 570                 575     


Ala Glu Arg Lys Asp Gly Ser His Pro Val His Val Asp Asn Cys Ile 
            580                 585                 590         


Leu Asn Ala Glu Ala Leu Val Cys Ile Lys Glu Pro Pro Ala Tyr Thr 
        595                 600                 605             


Phe Arg Asp Phe Ser Ala Ile Leu Tyr Leu Asn Glu Asp Phe Asp Gly 
    610                 615                 620                 


Gly Asn Phe Tyr Phe Thr Glu Leu Asp Ala Lys Thr Val Thr Ala Glu 
625                 630                 635                 640 


Val Gln Pro Gln Cys Gly Arg Ala Val Gly Phe Ser Ser Gly Thr Glu 
                645                 650                 655     


Asn Pro His Gly Val Lys Ala Val Thr Arg Gly Gln Arg Cys Ala Ile 
            660                 665                 670         


Ala Leu Trp Phe Thr Leu Asp Ala Arg His Ser Glu Arg Glu Arg Val 
        675                 680                 685             


Gln Ala Asp Asp Leu Val Lys Met Leu Phe Ser Pro Glu Glu Met Asp 
    690                 695                 700                 


Leu Pro His Glu Gln Pro Gln Glu Ala Gln Glu Gly Thr Pro Glu Pro 
705                 710                 715                 720 


Leu Gln Glu Pro Val Ser Ser Ser Glu Ser Gly His Lys Asp Glu Leu 
                725                 730                 735     


<210>  5
<211>  2580
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: Bos taurus prolyl 3-hydroxylase 1 (P3H1), 
       NCBI reference sequence NM_001103291.1

<400>  5
caagggtccc gttaggtctg agcggccatg gcggcacgcg ctttaaggct gctgaccata       60

ttgctggccg tcgccgccac tgcctcccag gctgaggccg agtccgaggc gggatgggac      120

ctgacggcgc ctgatctgct gttcgcggag gggacggcgg cctatgctcg cggggactgg      180

gccggtgtgg ttctgagcat ggagcgggcg ctccgctcgc gggccgccct gcgcgccctc      240

cgtctgcgct gccgcactcg gtgtgccgcc gacctcccat gggaagtgga cccagactcg      300

cccccaagct tggcgcaggc ttcaggtgcc tccgccctgc acgacctgcg gttcttcgga      360

ggcttgctgc gccgcgccgc ttgcctgcgc cgctgcctcg ggccgtcgac cgcccactcg      420

ctcagcgagg agctggagtt ggagttccgc aagcggagcc cctacaacta cctgcaggtc      480

gcctacttca agataaacaa gttggagaaa gctgtagcag cagcccatac cttcttcgtg      540

ggcaaccctg agcacatgga gatgcgacag aacctggact attaccagac catgtctggg      600

gtgaaggagg ctgacttcaa ggatcttgag gccaaacccc atatgcacga atttcggctg      660

ggagtgcgcc tctactccga ggagcagccg caggaagccg tgccccacct ggaggcggcg      720

ctgcgggagt acttcgtggc ggccgaggag tgccgcgcgc tctgcgaagg gccctatgac      780

tacgacggct acaactacct ggagtacaat gccgacctct tccaggccat cacagatcat      840

tacatccagg tcctcagctg taagcagaac tgtgtcacgg agcttgcttc ccacccaagt      900

cgagagaagc cctttgaaga cttcctgcca tctcattata attatctgca gtttgcctac      960

tataacattg ggaattacac acaggccatt gaatgtgcca agacctatct cctcttcttt     1020

cccaatgatg aggtgatgag ccagaatctg gcctactata cagccatgct tggagaagag     1080

caagccagat ccattggccc ccgtgagagt gcccaggagt accgccagcg gagcctgctg     1140

gagaaggaac tgcttttctt cgcctatgac gtttttggaa ttccctttgt tgatccggat     1200

tcatggactc cagtggaggt gattcctaag agactgcaag agaaacagaa gtcagaacgg     1260

gaaacagctg cccgcatctc ccaggaaatc gggaacctta tgaaggagat cgagaccctc     1320

gtggaggaga agaccaagga gtcactggac gtgagcaggc tgacccggga aggtggcccc     1380

ctgctgtatg atggcatcag actcaccatg aactccaaag tcctgaatgg ttcccagcgg     1440

gtggtgatgg atggcgtcat ctctgacgag gagtgccagg agctgcagag actgaccaat     1500

gcagcagcaa cttcaggaga tggctaccgg ggtcagacct ccccacacac ccccagcgag     1560

aagttctacg gtgtcaccgt cttcaaggcc ctcaagctgg ggcaggaagg gaaggttcct     1620

ctgcagagcg cccacctgta ctacaacgtg acggagaagg tgcgccgcgt catggagtcg     1680

tacttccgcc tggatacccc gctctacttc tcctactccc acctggtgtg ccgcaccgcc     1740

atcgaagagg cacaggctga gaggaaggac ggtagccacc ccgtccacgt ggacaactgc     1800

atcctgaatg ccgaggccct cgtgtgcatc aaggagcccc ctgcctacac tttccgggac     1860

ttcagcgcca ttctttatct gaacgaagac ttcgatggag gaaactttta tttcactgaa     1920

ctagatgcca agaccgtgac ggcagaggtg cagccccagt gcggaagggc tgtgggattc     1980

tcttccggca cggaaaaccc gcatggagta aaggccgtca ccagagggca gcgctgtgcc     2040

attgccctct ggttcacttt ggatgctcga cacagcgaga gggagcgagt gcaggcggac     2100

gacctggtaa agatgctctt tagcccagaa gagatggacc tcccccacga gcagccccaa     2160

gaagcccagg aggggacccc cgagccccta caggagcccg tctccagcag tgagtcaggg     2220

cacaaggatg agctctgaca actcccgtgg atggtgatca gacccacacg agggactctg     2280

tcctgcagcc tggactggcc agccccgggc gaggagcagt gggaacccag gcctgccgcc     2340

cagctgaggg ggctctgctc acggccgtcc gcatggtgct gctgctcttg gagtggacat     2400

ggcgagatgg ccctctcccc tctgggcctg actgagggct caggacgcag gcccagagcc     2460

actctggggg cccacacagg cagccacgtg acagcaatac agtatttaag tgcctgtgta     2520

gacaaccaaa gaataaatga ttcgtggttt tttttaaaaa aaaaaaaaaa aaaaaaaaaa     2580


<210>  6
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: procollagen-lysine 2-oxoglutarate 
       5-dioxygenase 1 precursor, Bos taurus, NCBI reference sequence 
       NP_776573.1

<400>  6

Met Arg Leu Leu Leu Leu Leu Ala Pro Leu Gly Trp Leu Leu Leu Ala 
1               5                   10                  15      


Glu Thr Lys Gly Asp Ala Lys Pro Glu Asp Asn Leu Leu Val Leu Thr 
            20                  25                  30          


Val Ala Thr Lys Glu Thr Glu Gly Phe Arg Arg Phe Lys Arg Ser Ala 
        35                  40                  45              


Gln Phe Phe Asn Tyr Lys Ile Gln Ala Leu Gly Leu Gly Glu Asp Trp 
    50                  55                  60                  


Pro Gly Glu Ala Met Leu Ala Gly Gly Gly Leu Lys Val Arg Leu Leu 
65                  70                  75                  80  


Lys Lys Ala Leu Glu Lys His Ala Asp Lys Glu Asn Leu Val Ile Leu 
                85                  90                  95      


Phe Thr Asp Ser Tyr Asp Val Val Phe Ala Ser Gly Pro Arg Glu Leu 
            100                 105                 110         


Leu Lys Lys Phe Arg Gln Ala Arg Ser Gln Val Val Phe Ser Ala Glu 
        115                 120                 125             


Glu Leu Ile Tyr Pro Asp Arg Arg Leu Glu Ala Asn Tyr Pro Val Val 
    130                 135                 140                 


Ser Asp Gly Lys Arg Phe Leu Gly Ser Gly Gly Phe Ile Gly Tyr Ala 
145                 150                 155                 160 


Pro Asn Leu Ile Lys Leu Val Ala Glu Trp Glu Gly Gln Asp Ser Asp 
                165                 170                 175     


Ser Asp Gln Leu Phe Tyr Thr Lys Ile Phe Leu Asp Pro Glu Lys Arg 
            180                 185                 190         


Glu Gln Ile Asn Ile Thr Leu Asp His Arg Cys Arg Ile Phe Gln Asn 
        195                 200                 205             


Phe His Gly Ala Leu Asp Glu Val Val Leu Lys Phe Glu Met Gly Gln 
    210                 215                 220                 


Val Arg Ala Arg Asn Leu Ala Tyr Asp Thr Leu Pro Val Leu Ile His 
225                 230                 235                 240 


Gly Asn Gly Pro Thr Lys Leu Gln Leu Asn Tyr Leu Gly Asn Tyr Ile 
                245                 250                 255     


Pro Arg Phe Trp Thr Phe Glu Thr Gly Cys Ala Val Cys Asp Glu Gly 
            260                 265                 270         


Leu Arg Ser Leu Lys Gly Ile Gly Asp Glu Ala Leu Pro Ala Val Leu 
        275                 280                 285             


Val Gly Val Phe Ile Glu Gln Pro Thr Pro Phe Leu Ser Leu Phe Phe 
    290                 295                 300                 


Gln Arg Leu Leu Leu Leu His Tyr Pro Gln Lys Arg Phe Arg Leu Phe 
305                 310                 315                 320 


Ile His Asn His Glu Gln His His Lys Ala Gln Val Glu Gln Phe Leu 
                325                 330                 335     


Ala Glu His Gly Asp Glu Tyr Gln Ser Val Lys Leu Val Gly Pro Glu 
            340                 345                 350         


Val Arg Val Ala Asn Ala Asp Ala Arg Asn Met Gly Ala Asp Leu Cys 
        355                 360                 365             


Arg Gln Asp Arg Gly Cys Thr Tyr Tyr Phe Ser Val Asp Ala Asp Val 
    370                 375                 380                 


Ala Leu Thr Glu Pro Lys Thr Leu Arg Leu Leu Ile Glu Gln Asn Lys 
385                 390                 395                 400 


Asn Val Ile Thr Pro Leu Met Thr Arg His Gly Arg Leu Trp Ser Asn 
                405                 410                 415     


Phe Trp Gly Ala Leu Ser Ala Asp Gly Tyr Tyr Ala Arg Ser Glu Asp 
            420                 425                 430         


Tyr Val Asp Ile Val Gln Gly Arg Arg Val Gly Val Trp Asn Val Pro 
        435                 440                 445             


Tyr Ile Ser Asn Ile Tyr Leu Ile Lys Gly Ser Ala Leu Arg Ala Glu 
    450                 455                 460                 


Leu Gln Glu Thr Asp Leu Phe His His Ser Lys Leu Asp Pro Asp Met 
465                 470                 475                 480 


Ala Phe Cys Ala Asn Ile Arg Gln Gln Asp Val Phe Met Phe Leu Thr 
                485                 490                 495     


Asn Arg His Ser Phe Gly His Leu Leu Ser Leu Asp Ser Tyr Gln Thr 
            500                 505                 510         


Thr His Leu His Asn Asp Leu Trp Glu Val Phe Ser Asn Pro Glu Asp 
        515                 520                 525             


Trp Lys Glu Lys Tyr Ile His Glu Asn Tyr Thr Lys Ala Leu Ala Gly 
    530                 535                 540                 


Lys Met Val Glu Met Pro Cys Pro Asp Val Tyr Trp Phe Pro Ile Phe 
545                 550                 555                 560 


Thr Glu Thr Ala Cys Asp Glu Leu Val Glu Glu Met Glu His Tyr Gly 
                565                 570                 575     


Gln Trp Ser Leu Gly Asp Asn Lys Asp Asn Arg Ile Gln Gly Gly Tyr 
            580                 585                 590         


Glu Asn Val Pro Thr Ile Asp Ile His Met Asn Gln Ile Asn Tyr Glu 
        595                 600                 605             


Arg Glu Trp His Lys Phe Leu Val Glu Tyr Ile Ala Pro Met Thr Glu 
    610                 615                 620                 


Lys Leu Tyr Pro Gly Tyr Tyr Thr Arg Ala Gln Phe Asp Leu Ala Phe 
625                 630                 635                 640 


Val Val Arg Tyr Lys Pro Asp Glu Gln Pro Ser Leu Val Pro His His 
                645                 650                 655     


Asp Ala Ser Thr Phe Thr Ile Asn Ile Gly Leu Asn Arg Val Gly Val 
            660                 665                 670         


Asp Tyr Glu Gly Gly Gly Cys Arg Phe Leu Arg Tyr Asn Cys Ser Ile 
        675                 680                 685             


Arg Ala Pro Arg Lys Gly Trp Thr Leu Met His Pro Gly Arg Leu Thr 
    690                 695                 700                 


His Tyr His Glu Gly Val Pro Thr Thr Lys Gly Thr Arg Tyr Ile Ala 
705                 710                 715                 720 


Val Ser Phe Val Asp Pro 
                725     


<210>  7
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: lysyl oxidase, Bos taurus, GenBank AAL13313.1


<220>
<221>  misc_feature
<222>  (253)..(253)
<223>  Xaa can be any naturally occurring amino acid

<400>  7

Met Arg Phe Ala Trp Thr Ala Leu Leu Gly Ser Leu Gln Leu Cys Ala 
1               5                   10                  15      


Leu Val Arg Cys Ala Pro Pro Ala Ala Ser His Arg Gln Pro Pro Arg 
            20                  25                  30          


Glu Gln Ala Ala Ala Pro Gly Ala Trp Arg Gln Lys Ile Gln Trp Glu 
        35                  40                  45              


Asn Asn Gly Gln Val Phe Ser Leu Leu Ser Leu Gly Ser Gln Tyr Gln 
    50                  55                  60                  


Pro Gln Arg Arg Arg Asp Pro Gly Ala Thr Ala Pro Gly Ala Ala Asn 
65                  70                  75                  80  


Ala Thr Ala Pro Gln Met Arg Thr Pro Ile Leu Leu Leu Arg Asn Asn 
                85                  90                  95      


Arg Thr Ala Ala Ala Arg Val Arg Thr Ala Gly Pro Ser Ala Ala Ala 
            100                 105                 110         


Ala Gly Arg Pro Arg Pro Ala Ala Arg His Trp Phe Gln Ala Gly Tyr 
        115                 120                 125             


Ser Thr Ser Gly Ala His Asp Ala Gly Thr Ser Arg Ala Asp Asn Gln 
    130                 135                 140                 


Thr Ala Pro Gly Glu Val Pro Thr Leu Ser Asn Leu Arg Pro Pro Asn 
145                 150                 155                 160 


Arg Val Glu Val Asp Gly Met Val Gly Asp Asp Pro Tyr Asn Pro Tyr 
                165                 170                 175     


Lys Tyr Thr Asp Asp Asn Pro Tyr Tyr Asn Tyr Tyr Asp Thr Tyr Glu 
            180                 185                 190         


Arg Pro Arg Pro Gly Ser Arg Tyr Arg Pro Gly Tyr Gly Thr Gly Tyr 
        195                 200                 205             


Phe Gln Tyr Gly Leu Pro Asp Leu Val Pro Asp Pro Tyr Tyr Ile Gln 
    210                 215                 220                 


Ala Ser Thr Tyr Val Gln Lys Met Ala Met Tyr Asn Leu Arg Cys Ala 
225                 230                 235                 240 


Ala Glu Glu Asn Cys Leu Ala Ser Ser Ala Tyr Arg Xaa Asp Val Arg 
                245                 250                 255     


Asp Tyr Asp His Arg Val Leu Leu Arg Phe Pro Gln Arg Val Lys Asn 
            260                 265                 270         


Gln Gly Thr Ser Asp Phe Leu Pro Ser Arg Pro Arg Tyr Ser Trp Glu 
        275                 280                 285             


Trp His Ser Cys His Gln His Tyr His Ser Met Asp Glu Phe Ser His 
    290                 295                 300                 


Tyr Asp Leu Leu Asp Ala Ser Thr Gln Arg Arg Val Ala Glu Gly His 
305                 310                 315                 320 


Lys Ala Ser Phe Cys Leu Glu Asp Thr Ser Cys Asp Tyr Gly Tyr His 
                325                 330                 335     


Arg Arg Phe Ala Cys Thr Ala His Thr Gln Gly Leu Ser Pro Gly Cys 
            340                 345                 350         


Tyr Asp Thr Tyr Asn Ala Asp Ile Asp Cys Gln Trp Ile Asp Ile Thr 
        355                 360                 365             


Asp Val Lys Pro Gly Asn Tyr Ile Leu Lys Val Ser Val Asn Pro Ser 
    370                 375                 380                 


Tyr Leu Val Pro Glu Ser Asp Tyr Ser Asn Asn Val Val Arg Cys Glu 
385                 390                 395                 400 


Ile Arg Tyr Thr Gly His His Ala Tyr Ala Ser Gly Cys Thr Ile Ser 
                405                 410                 415     


Pro Tyr 
        


<210>  8
<211>  1612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: bovine P4HA cDNA optimized

<400>  8
atgatttggt atatcctagt cgttggtatt ttgttgccac agtcactggc tcacccaggc       60

ttcttcactt ctataggaca gatgactgat ttgattcaca cagaaaaaga cctagttaca      120

agccttaaag actatatcaa agctgaagag gataagttgg agcaaatcaa aaagtgggca      180

gagaaactcg atagattgac tagtactgca acaaaagatc ctgagggttt tgtgggtcac      240

ccagtgaatg ctttcaagct gatgaagaga cttaatacag agtggtcaga attggaaaac      300

ttggtactta aagatatgag tgatggattc atttctaact taacaattca aagacaatac      360

tttccaaacg atgaggacca agtaggagca gcaaaagctt tgttgcgatt gcaggacaca      420

tacaatttgg acaccgacac gatatcgaag ggtgatttac ctggtgtgaa gcataagtcc      480

ttcctcactg tggaagattg ttttgaattg ggaaaagtcg catatacaga agccgactac      540

tatcacacag aattatggat ggagcaagct ctgcgtcagt tggacgaagg tgaagtttct      600

accgttgata aggtttcagt tttggattac ttatcatacg ctgtttacca gcaaggtgat      660

ctggacaaag ctctactttt aactaaaaag ttgttggagc tggacccgga gcatcaaaga      720

gctaacggta atctgaaata ctttgaatac atcatggcta aggaaaagga cgcaaataag      780

tcctcgtccg atgaccaatc cgatcaaaag accactctga aaaaaaaagg tgcagctgtt      840

gactacctcc cagagagaca aaagtatgaa atgctgtgta gaggagaggg tatcaagatg      900

actccaagga gacagaaaaa gctgttctgt agatatcatg atgggaaccg taacccaaaa      960

ttcattcttg ctccagcgaa acaggaagat gaatgggaca agcctagaat cattcgtttt     1020

catgacatca tctccgatgc agaaatagag gttgtgaaag acttggccaa accaagattg     1080

agtagggcta ccgtccatga ccctgagact ggaaaattga ctaccgcaca atatcgtgtc     1140

tctaaatcag catggttgtc cggttacgag aatcccgtgg tcagccgtat caatatgcgt     1200

attcaagatt tgactggtct tgacgtaagc actgctgagg aactacaagt tgccaactat     1260

ggtgtgggcg gtcagtatga accccacttt gatttcgcca gaaaggacga gcctgatgct     1320

tttaaggagc taggtactgg aaatagaatc gcaacgtggt tgttctatat gtccgatgtg     1380

cttgctggag gagccacagt tttccctgag gtaggtgctt ctgtttggcc taaaaagggc     1440

acggccgtat tttggtacaa tctgtttgca tctggagaag gtgattacag cactagacat     1500

gctgcttgtc ccgtcttagt cggtaataag tgggtttcca ataagtggct gcatgagaga     1560

ggtcaagagt ttaggaggcc atgcacattg tcagaattag aatgataatt tt             1612


<210>  9
<211>  1747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: bovine P4HB (PDI) sequence, with Alpha 
       pre-pro signal sequence, cDNA optimized

<400>  9
atgagattcc catctatttt caccgctgtc ttgttcgctg cctcctctgc attggctgcc       60

cctgttaaca ctaccactga agacgagact gctcaaattc cagctgaagc agttatcggt      120

tactctgacc ttgagggtga tttcgacgtc gctgttttgc ctttctctaa ctccactaac      180

aacggtttgt tgttcattaa caccactatc gcttccattg ctgctaagga agagggtgtc      240

tctctcgaga aaagagaggc cgaagctgca cccgatgagg aagatcatgt tttagtattg      300

cataaaggaa atttcgatga agctttggcc gctcacaaat atctgctcgt cgagttttac      360

gctccctggt gcggtcattg taaggccctt gcaccagagt acgccaaggc agctggtaag      420

ttaaaggccg aaggttcaga gatcagatta gcaaaagttg atgctacaga agagtccgat      480

cttgctcaac aatacggggt tcgaggatac ccaacaatta agtttttcaa aaatggtgat      540

actgcttccc caaaggaata tactgctggt agagaggcag acgacatagt caactggctc      600

aaaaagagaa cgggcccagc tgcgtctaca ttaagcgacg gagcagcagc cgaagctctt      660

gtggaatcta gtgaagttgc tgtaatcggt ttctttaagg acatggaatc tgattcagct      720

aaacagttcc ttttagcagc tgaagcaatc gatgacatcc ctttcggaat cacctcaaat      780

agtgacgtgt tcagcaagta ccaacttgac aaagatggag tggtcttgtt caaaaagttt      840

gacgaaggca gaaacaattt cgagggtgag gttacaaagg agaaactgct tgatttcatt      900

aaacataacc aactaccctt agttatcgaa ttcactgaac aaactgctcc taagattttc      960

ggtggagaaa tcaaaacaca tatcttgttg tttttgccaa agtccgtatc ggattatgaa     1020

ggtaaactct ccaatttcaa aaaggccgct gagagcttta agggcaagat tttgttcatc     1080

tttattgact cagaccacac agacaatcag aggattttgg agtttttcgg tttgaaaaag     1140

gaggaatgtc cagcagtccg tttgatcacc ttggaggagg agatgaccaa atacaaacca     1200

gagtcggatg agttgactgc cgagaagata acagaatttt gtcacagatt tctggaaggt     1260

aagatcaagc ctcatcttat gtctcaagag ttgcctgatg actgggataa gcaaccagtt     1320

aaagtattgg tgggtaaaaa ctttgaggaa gtggccttcg acgagaaaaa aaatgtcttt     1380

gttgaattct atgctccgtg gtgtggtcac tgtaagcagc tggcaccaat ttgggataaa     1440

ctgggtgaaa cttacaaaga tcacgaaaac attgttattg caaagatgga cagtactgct     1500

aacgaagtgg aggctgtgaa agttcactcc ttccctacgc tgaagttctt tcctgcatct     1560

gctgacagaa ctgttatcga ctataatgga gagaggacat tggatggttt taaaaagttt     1620

cttgaatccg gaggtcaaga cggagctggt gacgacgatg atttggaaga tctggaggag     1680

gctgaggaac ctgatcttga ggaggatgac gaccagaagg cagtcaaaga tgaactgtga     1740

taagggg                                                               1747


<210>  10
<211>  4404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: Col3A1 cDNA optimized

<400>  10
atgatgtctt ttgtccaaaa gggtacttgg ttactttttg ctctgttgca cccaactgtt       60

attctcgcac aacaggaagc agtagatggt ggttgctcac atttaggtca atcttacgca      120

gatagagatg tatggaaacc tgaaccatgt caaatttgcg tgtgtgactc aggttcagtg      180

ctctgcgacg atatcatatg tgacgaccag gaattggact gtccaaaccc agagatacca      240

ttcggtgaat gttgtgctgt ttgtccacag ccaccaactg ctcctacaag acctccaaac      300

ggtcaaggtc cacaaggtcc taaaggtgat ccgggtccac ctggtattcc tggtagaaat      360

ggtgaccctg gacctcccgg ttccccaggt agcccaggat cacctgggcc tcctggaata      420

tgtgaatcct gcccaactgg tggtcagaac tatagcccac aatacgaggc ctacgacgtc      480

aaatctggtg ttgctggagg aggtattgca ggctaccctg gtcccgcagg gcccccaggt      540

ccgccgggtc cgcccggaac atcaggtcat cccggagccc ctggtgcacc aggttatcag      600

ggaccgcccg gagagcctgg acaagctggt cccgctggac cccctggtcc accaggtgct      660

attggaccaa gtggtcctgc cggaaaagac ggtgaatccg gtagacctgg tagacccggc      720

gaaaggggtt tcccaggtcc tcccggaatg aagggtccag ccggtatgcc cggttttcct      780

gggatgaagg gtcacagagg atttgatggt agaaacggag agaaaggcga aaccggtgct      840

cccggactga agggtgaaaa cggtgtccct ggtgagaacg gcgctcctgg acctatgggt      900

ccacgtggtg ctccaggaga aagaggcaga ccaggattgc ctggtgcagc tggtgctaga      960

ggtaacgatg gtgcccgtgg ttccgatgga caacccgggc cacccggccc tccaggtacc     1020

gctggatttc ctggaagccc tggtgctaag ggggaggttg gtccggctgg tagtcccgga     1080

agtagcggtg ccccaggtca aagaggcgaa ccaggccctc agggtcacgc aggagcacct     1140

ggaccgcctg gtcctcctgg ttcgaatggt tcgcctggag gaaaaggtga aatggggccc     1200

gcaggaatcc ccggtgcgcc tggtcttatt ggtgccaggg gtcctccagg cccgccaggt     1260

acaaatggtg tacccggaca gcgaggagca gctggtgaac ctggtaaaaa cggtgccaaa     1320

ggagatccag gtcctcgtgg agagcgtggt gaagctggct ctcccggtat cgccggtcca     1380

aaaggtgagg acggtaagga cggttcccct ggtgagccag gtgcgaacgg actgccaggt     1440

gcagccggag agcgaggagt cccaggattc aggggaccag ccggtgctaa cggcttgcct     1500

ggtgaaaaag ggccccctgg tgatagggga ggacccggtc cagcaggccc tcgtggagtt     1560

gctggtgagc ctggacgtga cggtttacca ggagggccag gtttgagggg tattcccggg     1620

tcccctggcg gtcctggatc ggatggaaaa ccagggccac caggttcgca gggtgaaaca     1680

ggacgtccag gcccacccgg ctcacctggt ccaaggggtc agcctggtgt catgggtttc     1740

cccggtccaa agggtaatga cggagcaccg ggtaaaaatg gtgaacgtgg tggcccaggt     1800

ggtccaggac cccaaggtcc agctggaaaa aacggtgaga caggtcctca aggacctcca     1860

ggacctaccg gtcctagcgg agataaggga gatacgggac cgccaggacc tcaaggattg     1920

caaggtttgc ctggtacatc tggccctccc ggagaaaatg gtaagcctgg agagccagga     1980

ccaaaaggcg aagctggagc cccaggtatc cccggaggta agggagactc aggtgctccg     2040

ggtgagcgtg gtcctccggg tgccggtggt ccacctggac ctagaggtgg tgccgggccg     2100

ccaggtcctg aaggtggtaa aggtgctgct ggtccaccgg gaccgcctgg ctctgctggt     2160

actcctggct tgcagggaat gccaggagag agaggtggac ctggaggtcc cggtccgaag     2220

ggtgataaag gggagccagg atcatccggt gttgacggcg cacctggtaa agacggacca     2280

aggggaccaa cgggtccaat cggaccacca ggacccgctg gccagccagg agataaaggc     2340

gagtccggag cacccggtgt tcctggtata gctggaccca ggggtggtcc cggtgaaaga     2400

ggtgaacagg gcccaccggg tcccgccggt ttccctggcg cccctggtca aaatggagaa     2460

ccaggtgcaa agggcgagag aggagcccca ggagaaaagg gtgagggagg accacccggt     2520

gctgccggtc cagctggggg ttcaggtcct gctggaccac caggtccaca gggcgttaaa     2580

ggtgagagag gaagtccagg tggtcctgga gctgctggat tcccaggtgg ccgtggacct     2640

cctggtcccc ctggatcgaa tggtaatcct ggtccgccag gtagttcggg tgctcctggg     2700

aaggacggtc cacctggccc cccaggtagt aacggtgcac ctggtagtcc aggtatatcc     2760

ggacctaaag gagattccgg tccaccaggc gaaagagggg ccccaggccc acagggtcca     2820

ccaggagccc ccggtcctct gggtattgct ggtcttactg gtgcacgtgg actggccggt     2880

ccacccggaa tgcctggagc aagaggttca cctggaccac aaggtattaa aggagagaac     2940

ggtaaacctg gaccttccgg tcaaaacgga gagcggggac ccccaggccc ccaaggtctg     3000

ccaggactag ctggtaccgc aggggaacca ggaagagatg gaaatccagg ttcagacgga     3060

ctacccggta gagatggtgc accgggggcc aagggcgaca ggggtgagaa tggatctcct     3120

ggtgcgccag gggcaccagg ccacccaggt cccccaggtc ctgtgggccc tgctggaaag     3180

tcaggtgaca ggggagagac aggcccggct ggtccatctg gcgcacccgg accagctggt     3240

tccagaggcc cacctggtcc gcaaggccct agaggtgaca agggagagac tggagaacga     3300

ggtgctatgg gtatcaaggg tcatagaggt tttccgggta atcccggcgc cccaggttct     3360

cctggtccag ctggccatca aggtgcagtc ggatcgcccg gcccagccgg tcccaggggc     3420

cctgttggtc catccggtcc tccaggaaag gatggtgctt ctggacaccc aggacctatc     3480

ggacctccgg gtcctagagg taatagagga gaacgtggat ccgagggtag tcctggtcac     3540

cctggtcaac ctggcccacc agggcctcca ggtgcacccg gtccatgttg tggtgcaggc     3600

ggtgtggctg caattgctgg tgtgggtgct gaaaaggccg gcggtttcgc tccatattat     3660

ggtgatgaac cgattgattt taagatcaat actgacgaaa tcatgacttc cttaaagtcc     3720

gttaatggtc aaattgagtc tctaatctcc ccagatggtt cacgtaaaaa tcctgctaga     3780

aattgtagag atttgaagtt ttgtcacccc gagttgcagt ccggtgagta ctgggtggac     3840

cccaatcaag gttgtaagtt agacgctatt aaagtttact gcaatatgga gacaggagaa     3900

acttgcatca gcgcttctcc attgactatc ccacaaaaaa attggtggac tgactctgga     3960

gctgagaaaa agcatgtatg gttcggggaa tcgatggaag gtggtttcca attcagctac     4020

ggtaaccctg aacttcctga agatgttctt gacgttcaat tggcatttct gagattgttg     4080

tccagtcgtg caagccaaaa cattacatac cattgcaaaa attccatcgc atatatggat     4140

catgctagcg gaaatgtgaa aaaggcattg aagctgatgg gatcaaatga aggtgaattt     4200

aaagcagagg gtaattctaa gtttacttac actgtattgg aggatggttg tacgaagcat     4260

acaggtgaat ggggtaaaac agtgtttcaa tatcaaaccc gcaaagcagt tagattgcca     4320

atcgtcgata tcgcaccata cgacattgga ggaccagatc aagagttcgg agctgacatc     4380

ggtccggtgt gtttcctttg ataa                                            4404


<210>  11
<211>  1463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: collagen alpha-1(I) chain precursor (Bos 
       taurus), NCBI reference sequence NP_001029211.1

<400>  11

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Glu Glu Gly Gln Glu 
            20                  25                  30          


Glu Asp Ile Pro Pro Val Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Val Pro Cys Gln Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Asn Val Leu Cys Asp Asp Val Ile Cys Asp Glu Leu Lys Asp 
65                  70                  75                  80  


Cys Pro Asn Ala Lys Val Pro Thr Asp Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Glu Gly Gln Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Ile Ser Val 
                165                 170                 175     


Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro Pro 
            180                 185                 190         


Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro Gly 
        195                 200                 205             


Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly Pro 
    210                 215                 220                 


Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg Pro 
225                 230                 235                 240 


Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro Gly 
                245                 250                 255     


Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly Leu 
            260                 265                 270         


Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu Pro 
        275                 280                 285             


Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg Gly 
    290                 295                 300                 


Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly Ala 
305                 310                 315                 320 


Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro Thr 
                325                 330                 335     


Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys Gly 
            340                 345                 350         


Glu Gly Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly Val 
        355                 360                 365             


Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro Ala 
    370                 375                 380                 


Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn Gly 
385                 390                 395                 400 


Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly Pro 
                405                 410                 415     


Ser Gly Pro Gln Gly Pro Ser Gly Pro Pro Gly Pro Lys Gly Asn Ser 
            420                 425                 430         


Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys Gly 
        435                 440                 445             


Glu Pro Gly Pro Thr Gly Ile Gln Gly Pro Pro Gly Pro Ala Gly Glu 
    450                 455                 460                 


Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro Gly 
                485                 490                 495     


Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly Ala 
            500                 505                 510         


Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg Pro 
        515                 520                 525             


Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro Gly 
    530                 535                 540                 


Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly Gln 
545                 550                 555                 560 


Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln Ala 
                565                 570                 575     


Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro Gly 
            580                 585                 590         


Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly Pro 
        595                 600                 605             


Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro Ala 
    610                 615                 620                 


Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro Gly 
625                 630                 635                 640 


Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly Lys 
                645                 650                 655     


Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro Ser 
            660                 665                 670         


Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln Gly 
        675                 680                 685             


Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly Asn 
    690                 695                 700                 


Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser Gln 
705                 710                 715                 720 


Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala Gly 
                725                 730                 735     


Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly Ala 
            740                 745                 750         


Asp Gly Ala Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro Ile 
        755                 760                 765             


Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ala Gly 
    770                 775                 780                 


Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly Asp 
785                 790                 795                 800 


Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro Pro 
                805                 810                 815     


Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala Gly 
            820                 825                 830         


Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly Pro 
        835                 840                 845             


Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Pro Lys Gly Ala Arg 
    850                 855                 860                 


Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala Gly 
865                 870                 875                 880 


Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly Pro 
                885                 890                 895     


Pro Gly Pro Ala Gly Lys Glu Gly Ser Lys Gly Pro Arg Gly Glu Thr 
            900                 905                 910         


Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro Gly 
        915                 920                 925             


Pro Ala Gly Glu Lys Gly Ala Pro Gly Ala Asp Gly Pro Ala Gly Ala 
    930                 935                 940                 


Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val Val 
945                 950                 955                 960 


Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro Gly 
                965                 970                 975     


Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly Glu 
            980                 985                 990         


Arg Gly Pro Pro Gly Pro Met Gly  Pro Pro Gly Leu Ala  Gly Pro Pro 
        995                 1000                 1005             


Gly Glu  Ser Gly Arg Glu Gly  Ala Pro Gly Ala Glu  Gly Ser Pro 
    1010                 1015                 1020             


Gly Arg  Asp Gly Ser Pro Gly  Ala Lys Gly Asp Arg  Gly Glu Thr 
    1025                 1030                 1035             


Gly Pro  Ala Gly Pro Pro Gly  Ala Pro Gly Ala Pro  Gly Ala Pro 
    1040                 1045                 1050             


Gly Pro  Val Gly Pro Ala Gly  Lys Ser Gly Asp Arg  Gly Glu Thr 
    1055                 1060                 1065             


Gly Pro  Ala Gly Pro Ala Gly  Pro Ile Gly Pro Val  Gly Ala Arg 
    1070                 1075                 1080             


Gly Pro  Ala Gly Pro Gln Gly  Pro Arg Gly Asp Lys  Gly Glu Thr 
    1085                 1090                 1095             


Gly Glu  Gln Gly Asp Arg Gly  Ile Lys Gly His Arg  Gly Phe Ser 
    1100                 1105                 1110             


Gly Leu  Gln Gly Pro Pro Gly  Pro Pro Gly Ser Pro  Gly Glu Gln 
    1115                 1120                 1125             


Gly Pro  Ser Gly Ala Ser Gly  Pro Ala Gly Pro Arg  Gly Pro Pro 
    1130                 1135                 1140             


Gly Ser  Ala Gly Ser Pro Gly  Lys Asp Gly Leu Asn  Gly Leu Pro 
    1145                 1150                 1155             


Gly Pro  Ile Gly Pro Pro Gly  Pro Arg Gly Arg Thr  Gly Asp Ala 
    1160                 1165                 1170             


Gly Pro  Ala Gly Pro Pro Gly  Pro Pro Gly Pro Pro  Gly Pro Pro 
    1175                 1180                 1185             


Gly Pro  Pro Ser Gly Gly Tyr  Asp Leu Ser Phe Leu  Pro Gln Pro 
    1190                 1195                 1200             


Pro Gln  Glu Lys Ala His Asp  Gly Gly Arg Tyr Tyr  Arg Ala Asp 
    1205                 1210                 1215             


Asp Ala  Asn Val Val Arg Asp  Arg Asp Leu Glu Val  Asp Thr Thr 
    1220                 1225                 1230             


Leu Lys  Ser Leu Ser Gln Gln  Ile Glu Asn Ile Arg  Ser Pro Glu 
    1235                 1240                 1245             


Gly Ser  Arg Lys Asn Pro Ala  Arg Thr Cys Arg Asp  Leu Lys Met 
    1250                 1255                 1260             


Cys His  Ser Asp Trp Lys Ser  Gly Glu Tyr Trp Ile  Asp Pro Asn 
    1265                 1270                 1275             


Gln Gly  Cys Asn Leu Asp Ala  Ile Lys Val Phe Cys  Asn Met Glu 
    1280                 1285                 1290             


Thr Gly  Glu Thr Cys Val Tyr  Pro Thr Gln Pro Ser  Val Ala Gln 
    1295                 1300                 1305             


Lys Asn  Trp Tyr Ile Ser Lys  Asn Pro Lys Glu Lys  Arg His Val 
    1310                 1315                 1320             


Trp Tyr  Gly Glu Ser Met Thr  Gly Gly Phe Gln Phe  Glu Tyr Gly 
    1325                 1330                 1335             


Gly Gln  Gly Ser Asp Pro Ala  Asp Val Ala Ile Gln  Leu Thr Phe 
    1340                 1345                 1350             


Leu Arg  Leu Met Ser Thr Glu  Ala Ser Gln Asn Ile  Thr Tyr His 
    1355                 1360                 1365             


Cys Lys  Asn Ser Val Ala Tyr  Met Asp Gln Gln Thr  Gly Asn Leu 
    1370                 1375                 1380             


Lys Lys  Ala Leu Leu Leu Gln  Gly Ser Asn Glu Ile  Glu Ile Arg 
    1385                 1390                 1395             


Ala Glu  Gly Asn Ser Arg Phe  Thr Tyr Ser Val Thr  Tyr Asp Gly 
    1400                 1405                 1410             


Cys Thr  Ser His Thr Gly Ala  Trp Gly Lys Thr Val  Ile Glu Tyr 
    1415                 1420                 1425             


Lys Thr  Thr Lys Thr Ser Arg  Leu Pro Ile Ile Asp  Val Ala Pro 
    1430                 1435                 1440             


Leu Asp  Val Gly Ala Pro Asp  Gln Glu Phe Gly Phe  Asp Val Gly 
    1445                 1450                 1455             


Pro Ala  Cys Phe Leu 
    1460             


<210>  12
<211>  1364
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: collagen alpha-2(I) chain precursor (Bos 
       taurus), NCBI reference sequence: NP_776945.1

<400>  12

Met Leu Ser Phe Val Asp Thr Arg Thr Leu Leu Leu Leu Ala Val Thr 
1               5                   10                  15      


Ser Cys Leu Ala Thr Cys Gln Ser Leu Gln Glu Ala Thr Ala Arg Lys 
            20                  25                  30          


Gly Pro Ser Gly Asp Arg Gly Pro Arg Gly Glu Arg Gly Pro Pro Gly 
        35                  40                  45              


Pro Pro Gly Arg Asp Gly Asp Asp Gly Ile Pro Gly Pro Pro Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala Ala Gln 
65                  70                  75                  80  


Phe Asp Ala Lys Gly Gly Gly Pro Gly Pro Met Gly Leu Met Gly Pro 
                85                  90                  95      


Arg Gly Pro Pro Gly Ala Ser Gly Ala Pro Gly Pro Gln Gly Phe Gln 
            100                 105                 110         


Gly Pro Pro Gly Glu Pro Gly Glu Pro Gly Gln Thr Gly Pro Ala Gly 
        115                 120                 125             


Ala Arg Gly Pro Pro Gly Pro Pro Gly Lys Ala Gly Glu Asp Gly His 
    130                 135                 140                 


Pro Gly Lys Pro Gly Arg Pro Gly Glu Arg Gly Val Val Gly Pro Gln 
145                 150                 155                 160 


Gly Ala Arg Gly Phe Pro Gly Thr Pro Gly Leu Pro Gly Phe Lys Gly 
                165                 170                 175     


Ile Arg Gly His Asn Gly Leu Asp Gly Leu Lys Gly Gln Pro Gly Ala 
            180                 185                 190         


Pro Gly Val Lys Gly Glu Pro Gly Ala Pro Gly Glu Asn Gly Thr Pro 
        195                 200                 205             


Gly Gln Thr Gly Ala Arg Gly Leu Pro Gly Glu Arg Gly Arg Val Gly 
    210                 215                 220                 


Ala Pro Gly Pro Ala Gly Ala Arg Gly Ser Asp Gly Ser Val Gly Pro 
225                 230                 235                 240 


Val Gly Pro Ala Gly Pro Ile Gly Ser Ala Gly Pro Pro Gly Phe Pro 
                245                 250                 255     


Gly Ala Pro Gly Pro Lys Gly Glu Leu Gly Pro Val Gly Asn Pro Gly 
            260                 265                 270         


Pro Ala Gly Pro Ala Gly Pro Arg Gly Glu Val Gly Leu Pro Gly Leu 
        275                 280                 285             


Ser Gly Pro Val Gly Pro Pro Gly Asn Pro Gly Ala Asn Gly Leu Pro 
    290                 295                 300                 


Gly Ala Lys Gly Ala Ala Gly Leu Pro Gly Val Ala Gly Ala Pro Gly 
305                 310                 315                 320 


Leu Pro Gly Pro Arg Gly Ile Pro Gly Pro Val Gly Ala Ala Gly Ala 
                325                 330                 335     


Thr Gly Ala Arg Gly Leu Val Gly Glu Pro Gly Pro Ala Gly Ser Lys 
            340                 345                 350         


Gly Glu Ser Gly Asn Lys Gly Glu Pro Gly Ala Val Gly Gln Pro Gly 
        355                 360                 365             


Pro Pro Gly Pro Ser Gly Glu Glu Gly Lys Arg Gly Ser Thr Gly Glu 
    370                 375                 380                 


Ile Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Leu Arg Gly Asn Pro 
385                 390                 395                 400 


Gly Ser Arg Gly Leu Pro Gly Ala Asp Gly Arg Ala Gly Val Met Gly 
                405                 410                 415     


Pro Ala Gly Ser Arg Gly Ala Thr Gly Pro Ala Gly Val Arg Gly Pro 
            420                 425                 430         


Asn Gly Asp Ser Gly Arg Pro Gly Glu Pro Gly Leu Met Gly Pro Arg 
        435                 440                 445             


Gly Phe Pro Gly Ser Pro Gly Asn Ile Gly Pro Ala Gly Lys Glu Gly 
    450                 455                 460                 


Pro Val Gly Leu Pro Gly Ile Asp Gly Arg Pro Gly Pro Ile Gly Pro 
465                 470                 475                 480 


Ala Gly Ala Arg Gly Glu Pro Gly Asn Ile Gly Phe Pro Gly Pro Lys 
                485                 490                 495     


Gly Pro Ser Gly Asp Pro Gly Lys Ala Gly Glu Lys Gly His Ala Gly 
            500                 505                 510         


Leu Ala Gly Ala Arg Gly Ala Pro Gly Pro Asp Gly Asn Asn Gly Ala 
        515                 520                 525             


Gln Gly Pro Pro Gly Leu Gln Gly Val Gln Gly Gly Lys Gly Glu Gln 
    530                 535                 540                 


Gly Pro Ala Gly Pro Pro Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Thr Ala Gly Glu Ala Gly Lys Pro Gly Glu Arg Gly Ile Pro Gly Glu 
                565                 570                 575     


Phe Gly Leu Pro Gly Pro Ala Gly Ala Arg Gly Glu Arg Gly Pro Pro 
            580                 585                 590         


Gly Glu Ser Gly Ala Ala Gly Pro Thr Gly Pro Ile Gly Ser Arg Gly 
        595                 600                 605             


Pro Ser Gly Pro Pro Gly Pro Asp Gly Asn Lys Gly Glu Pro Gly Val 
    610                 615                 620                 


Val Gly Ala Pro Gly Thr Ala Gly Pro Ser Gly Pro Ser Gly Leu Pro 
625                 630                 635                 640 


Gly Glu Arg Gly Ala Ala Gly Ile Pro Gly Gly Lys Gly Glu Lys Gly 
                645                 650                 655     


Glu Thr Gly Leu Arg Gly Asp Ile Gly Ser Pro Gly Arg Asp Gly Ala 
            660                 665                 670         


Arg Gly Ala Pro Gly Ala Ile Gly Ala Pro Gly Pro Ala Gly Ala Asn 
        675                 680                 685             


Gly Asp Arg Gly Glu Ala Gly Pro Ala Gly Pro Ala Gly Pro Ala Gly 
    690                 695                 700                 


Pro Arg Gly Ser Pro Gly Glu Arg Gly Glu Val Gly Pro Ala Gly Pro 
705                 710                 715                 720 


Asn Gly Phe Ala Gly Pro Ala Gly Ala Ala Gly Gln Pro Gly Ala Lys 
                725                 730                 735     


Gly Glu Arg Gly Thr Lys Gly Pro Lys Gly Glu Asn Gly Pro Val Gly 
            740                 745                 750         


Pro Thr Gly Pro Val Gly Ala Ala Gly Pro Ser Gly Pro Asn Gly Pro 
        755                 760                 765             


Pro Gly Pro Ala Gly Ser Arg Gly Asp Gly Gly Pro Pro Gly Ala Thr 
    770                 775                 780                 


Gly Phe Pro Gly Ala Ala Gly Arg Thr Gly Pro Pro Gly Pro Ser Gly 
785                 790                 795                 800 


Ile Ser Gly Pro Pro Gly Pro Pro Gly Pro Ala Gly Lys Glu Gly Leu 
                805                 810                 815     


Arg Gly Pro Arg Gly Asp Gln Gly Pro Val Gly Arg Ser Gly Glu Thr 
            820                 825                 830         


Gly Ala Ser Gly Pro Pro Gly Phe Val Gly Glu Lys Gly Pro Ser Gly 
        835                 840                 845             


Glu Pro Gly Thr Ala Gly Pro Pro Gly Thr Pro Gly Pro Gln Gly Leu 
    850                 855                 860                 


Leu Gly Ala Pro Gly Phe Leu Gly Leu Pro Gly Ser Arg Gly Glu Arg 
865                 870                 875                 880 


Gly Leu Pro Gly Val Ala Gly Ser Val Gly Glu Pro Gly Pro Leu Gly 
                885                 890                 895     


Ile Ala Gly Pro Pro Gly Ala Arg Gly Pro Pro Gly Asn Val Gly Asn 
            900                 905                 910         


Pro Gly Val Asn Gly Ala Pro Gly Glu Ala Gly Arg Asp Gly Asn Pro 
        915                 920                 925             


Gly Asn Asp Gly Pro Pro Gly Arg Asp Gly Gln Pro Gly His Lys Gly 
    930                 935                 940                 


Glu Arg Gly Tyr Pro Gly Asn Ala Gly Pro Val Gly Ala Ala Gly Ala 
945                 950                 955                 960 


Pro Gly Pro Gln Gly Pro Val Gly Pro Val Gly Lys His Gly Asn Arg 
                965                 970                 975     


Gly Glu Pro Gly Pro Ala Gly Ala Val Gly Pro Ala Gly Ala Val Gly 
            980                 985                 990         


Pro Arg Gly Pro Ser Gly Pro Gln  Gly Ile Arg Gly Asp  Lys Gly Glu 
        995                 1000                 1005             


Pro Gly  Asp Lys Gly Pro Arg  Gly Leu Pro Gly Leu  Lys Gly His 
    1010                 1015                 1020             


Asn Gly  Leu Gln Gly Leu Pro  Gly Leu Ala Gly His  His Gly Asp 
    1025                 1030                 1035             


Gln Gly  Ala Pro Gly Ala Val  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1040                 1045                 1050             


Ala Gly  Pro Ser Gly Pro Ala  Gly Lys Asp Gly Arg  Ile Gly Gln 
    1055                 1060                 1065             


Pro Gly  Ala Val Gly Pro Ala  Gly Ile Arg Gly Ser  Gln Gly Ser 
    1070                 1075                 1080             


Gln Gly  Pro Ala Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1085                 1090                 1095             


Pro Gly  Pro Ser Gly Gly Gly  Tyr Glu Phe Gly Phe  Asp Gly Asp 
    1100                 1105                 1110             


Phe Tyr  Arg Ala Asp Gln Pro  Arg Ser Pro Thr Ser  Leu Arg Pro 
    1115                 1120                 1125             


Lys Asp  Tyr Glu Val Asp Ala  Thr Leu Lys Ser Leu  Asn Asn Gln 
    1130                 1135                 1140             


Ile Glu  Thr Leu Leu Thr Pro  Glu Gly Ser Arg Lys  Asn Pro Ala 
    1145                 1150                 1155             


Arg Thr  Cys Arg Asp Leu Arg  Leu Ser His Pro Glu  Trp Ser Ser 
    1160                 1165                 1170             


Gly Tyr  Tyr Trp Ile Asp Pro  Asn Gln Gly Cys Thr  Met Asp Ala 
    1175                 1180                 1185             


Ile Lys  Val Tyr Cys Asp Phe  Ser Thr Gly Glu Thr  Cys Ile Arg 
    1190                 1195                 1200             


Ala Gln  Pro Glu Asp Ile Pro  Val Lys Asn Trp Tyr  Arg Asn Ser 
    1205                 1210                 1215             


Lys Ala  Lys Lys His Val Trp  Val Gly Glu Thr Ile  Asn Gly Gly 
    1220                 1225                 1230             


Thr Gln  Phe Glu Tyr Asn Val  Glu Gly Val Thr Thr  Lys Glu Met 
    1235                 1240                 1245             


Ala Thr  Gln Leu Ala Phe Met  Arg Leu Leu Ala Asn  His Ala Ser 
    1250                 1255                 1260             


Gln Asn  Ile Thr Tyr His Cys  Lys Asn Ser Ile Ala  Tyr Met Asp 
    1265                 1270                 1275             


Glu Glu  Thr Gly Asn Leu Lys  Lys Ala Val Ile Leu  Gln Gly Ser 
    1280                 1285                 1290             


Asn Asp  Val Glu Leu Val Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr 
    1295                 1300                 1305             


Thr Val  Leu Val Asp Gly Cys  Ser Lys Lys Thr Asn  Glu Trp Gln 
    1310                 1315                 1320             


Lys Thr  Ile Ile Glu Tyr Lys  Thr Asn Lys Pro Ser  Arg Leu Pro 
    1325                 1330                 1335             


Ile Leu  Asp Ile Ala Pro Leu  Asp Ile Gly Gly Ala  Asp Gln Glu 
    1340                 1345                 1350             


Ile Arg  Leu Asn Ile Gly Pro  Val Cys Phe Lys 
    1355                 1360                 


<210>  13
<211>  1466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: collagen alpha-1(III) chain precursor (Bos 
       taurus), NCBI reference sequence: NP_001070299.1

<400>  13

Met Met Ser Phe Val Gln Lys Gly Thr Trp Leu Leu Phe Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Val Ile Leu Ala Gln Gln Glu Ala Val Asp Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Pro Pro Gly Ser 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Gly Gln Asn Tyr Ser Pro Gln Tyr Glu Ala Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Gly Gly Gly Ile Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ala Pro Gly Ala Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ala Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Phe Pro Gly Pro Pro Gly Met Lys Gly Pro Ala Gly Met 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Val Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Ser Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Pro Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ser Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Ile Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Pro Gly Thr Asn Gly Val Pro Gly Gln Arg Gly Ala Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Asp Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ser Pro Gly Ile Ala Gly Pro Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Val Pro Gly Phe Arg Gly Pro Ala Gly Ala 
                485                 490                 495     


Asn Gly Leu Pro Gly Glu Lys Gly Pro Pro Gly Asp Arg Gly Gly Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Val Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Leu Pro Gly Gly Pro Gly Leu Arg Gly Ile Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Thr 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Ser Pro Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Ala 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Ser Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Ser Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Glu Ala Gly Ala Pro Gly Ile Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ser Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Ala 
        675                 680                 685             


Gly Gly Pro Pro Gly Pro Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ser Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Pro Gly Gly 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Ser Ser Gly Val Asp 
            740                 745                 750         


Gly Ala Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Ser Gly Ala 
    770                 775                 780                 


Pro Gly Val Pro Gly Ile Ala Gly Pro Arg Gly Gly Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Gln Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Ala Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Ala Ala Gly Pro Ala Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Gly Arg Gly Pro 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Ser Ser 
                885                 890                 895     


Gly Ala Pro Gly Lys Asp Gly Pro Pro Gly Pro Pro Gly Ser Asn Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Ile Ser Gly Pro Lys Gly Asp Ser Gly Pro 
        915                 920                 925             


Pro Gly Glu Arg Gly Ala Pro Gly Pro Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Leu Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Ala Arg Gly Ser Pro Gly Pro Gln Gly Ile 
                965                 970                 975     


Lys Gly Glu Asn Gly Lys Pro Gly Pro Ser Gly Gln Asn Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ala Pro Gly Ala  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Thr Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ser Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Pro Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Met Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  His Gln Gly 
    1115                 1120                 1125             


Ala Val  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Ala Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Ala Gly  Gly Val Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Val Gly Ala  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Ile  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Gln Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Tyr 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Ser Pro Leu 
    1295                 1300                 1305             


Thr Ile  Pro Gln Lys Asn Trp  Trp Thr Asp Ser Gly  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Glu Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val Gln 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  His Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Gly  Lys Thr Val 
    1415                 1420                 1425             


Phe Gln  Tyr Gln Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Ala 
    1445                 1450                 1455             


Asp Ile  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  14
<211>  403
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: bifunctional arginine demethylase and 
       lysyl-hydroxylase JMJD6 (Bos taurus), NCBI reference sequence: 
       NP_001029492.2

<400>  14

Met Asn His Lys Ser Lys Lys Arg Ile Arg Glu Ala Lys Arg Ser Ala 
1               5                   10                  15      


Arg Pro Glu Leu Lys Asp Ser Leu Asp Trp Thr Arg His Asn Tyr Phe 
            20                  25                  30          


Glu Ser Phe Pro Leu Asn Pro Ala Ala Val Ala Asp Asn Val Glu Arg 
        35                  40                  45              


Ala Asp Ala Leu Gln Leu Ser Val Glu Glu Phe Val Glu Arg Tyr Glu 
    50                  55                  60                  


Arg Pro Tyr Lys Pro Val Val Leu Leu Asn Ala Gln Glu Gly Trp Ser 
65                  70                  75                  80  


Ala Gln Glu Lys Trp Thr Leu Glu Arg Leu Lys Arg Lys Tyr Arg Asn 
                85                  90                  95      


Gln Lys Phe Lys Cys Gly Glu Asp Asn Asp Gly Tyr Ser Val Lys Met 
            100                 105                 110         


Lys Met Lys Tyr Tyr Ile Glu Tyr Met Glu Ser Thr Arg Asp Asp Ser 
        115                 120                 125             


Pro Leu Tyr Ile Phe Asp Ser Ser Tyr Gly Glu His Pro Lys Arg Arg 
    130                 135                 140                 


Lys Leu Leu Glu Asp Tyr Lys Val Pro Lys Phe Phe Thr Asp Asp Leu 
145                 150                 155                 160 


Phe Gln Tyr Ala Gly Glu Lys Arg Arg Pro Pro Tyr Arg Trp Phe Val 
                165                 170                 175     


Met Gly Pro Pro Arg Ser Gly Thr Gly Ile His Ile Asp Pro Leu Gly 
            180                 185                 190         


Thr Ser Ala Trp Asn Ala Leu Val Gln Gly His Lys Arg Trp Cys Leu 
        195                 200                 205             


Phe Pro Thr Ser Thr Pro Arg Glu Leu Ile Lys Val Thr Arg Glu Glu 
    210                 215                 220                 


Gly Gly Asn Gln Gln Asp Glu Ala Ile Thr Trp Phe Asn Ile Ile Tyr 
225                 230                 235                 240 


Pro Arg Thr Gln Leu Pro Thr Trp Pro Pro Glu Phe Lys Pro Leu Glu 
                245                 250                 255     


Ile Leu Gln Lys Pro Gly Glu Thr Val Phe Val Pro Gly Gly Trp Trp 
            260                 265                 270         


His Val Val Leu Asn Leu Asp Thr Thr Ile Ala Ile Thr Gln Asn Phe 
        275                 280                 285             


Ala Ser Ser Thr Asn Phe Pro Val Val Trp His Lys Thr Val Arg Gly 
    290                 295                 300                 


Arg Pro Lys Leu Ser Arg Lys Trp Tyr Arg Ile Leu Lys Gln Glu His 
305                 310                 315                 320 


Pro Glu Leu Ala Val Leu Ala Asp Ser Val Asp Leu Gln Glu Ser Thr 
                325                 330                 335     


Gly Ile Ala Ser Asp Ser Ser Ser Asp Ser Ser Ser Ser Ser Ser Ser 
            340                 345                 350         


Ser Ser Ser Asp Ser Asp Ser Glu Cys Glu Ser Gly Ser Glu Gly Glu 
        355                 360                 365             


Gly Thr Met His Arg Arg Lys Lys Arg Arg Thr Cys Gly Met Val Gly 
    370                 375                 380                 


Asn Gly Asp Thr Thr Ser Gln Asp Asp Cys Val Ser Lys Glu Arg Ser 
385                 390                 395                 400 


Ser Ser Arg 
            


<210>  15
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: bovine P4HA cDNA native

<400>  15
atgatctggt atattttagt tgtagggatt ctacttcccc agtctttggc ccatccaggc       60

ttttttactt ctattggtca gatgactgat ttgattcata ctgaaaaaga tctggtgact      120

tccctgaaag actatataaa ggcagaagag gacaaattag aacaaataaa aaaatgggca      180

gagaaattag atcgattaac cagcacagcg acaaaagatc cagaaggatt tgttggacac      240

cctgtaaatg cattcaaatt aatgaaacgt ctgaacactg agtggagtga gttggagaat      300

ctggtcctta aggatatgtc agatggtttt atctctaacc taaccattca gagacagtac      360

ttccctaatg atgaagatca ggttggggca gccaaagctc tgttgcgtct acaggacacc      420

tacaatttgg atacagatac catctcaaag ggtgatcttc caggagtaaa acacaaatct      480

tttctaacag ttgaggactg ttttgagttg ggcaaagtgg cctacacaga agcagattat      540

taccatacag agctgtggat ggaacaagca ctgaggcagc tggatgaagg cgaggtttct      600

accgttgata aagtctctgt tctggattat ttgagctatg cagtatacca gcagggagac      660

ctggataagg cgcttttgct cacaaagaag cttcttgaac tagatcctga acatcagaga      720

gctaacggta acttaaaata ctttgagtat ataatggcta aagaaaaaga tgccaataag      780

tcttcttcag atgaccaatc tgatcagaaa accacactga agaagaaagg tgctgctgtg      840

gattacctgc cagagagaca gaagtacgaa atgctgtgcc gtggggaggg tatcaaaatg      900

actcctcgga gacagaaaaa actcttctgt cgctaccatg atggaaaccg gaatcctaaa      960

tttatcctgg ctccagccaa acaggaggat gagtgggaca agcctcgtat tatccgcttc     1020

catgatatta tttctgatgc agaaattgaa gtcgttaaag atctagcaaa accaaggctg     1080

aggcgagcca ccatttcaaa cccaataaca ggagacttgg agacggtaca ttacagaatt     1140

agcaaaagtg cctggctgtc tggctatgaa aaccctgtgg tgtcacgaat taatatgaga     1200

atccaagatc tgacaggact agatgtctcc acagcagagg aattacaggt agcaaattat     1260

ggagttggag gacagtatga accccatttt gattttgcac ggaaagatga gccagatgct     1320

ttcaaagagc tggggacagg aaatagaatt gctacatggc tgttttatat gagtgatgtg     1380

ttagcaggag gagccactgt ttttcctgaa gtaggagcta gtgtttggcc caaaaaggga     1440

actgctgttt tctggtataa tctgtttgcc agtggagaag gagattatag tacacggcat     1500

gcagcctgtc cagtgctggt tggaaacaaa tgggtatcca ataaatggct ccatgaacgt     1560

ggacaggaat ttcgaagacc atgcaccttg tcagaattgg aatga                     1605


<210>  16
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: bovine P4HB (PDI) sequence, native with own
       signal peptide

<400>  16
atgctgcgcc gcgctctgct ctgcctggcc ctgaccgcgc tattccgcgc gggtgccggc       60

gcccccgacg aggaggacca cgtcctggtg ctccataagg gcaacttcga cgaggcgctg      120

gcggcccaca agtacctgct ggtggagttc tacgccccat ggtgcggcca ctgcaaggct      180

ctggccccgg agtatgccaa agcagctggg aagctgaagg cagaaggttc tgagatcaga      240

ctggccaagg tggatgccac tgaagagtct gacctggccc agcagtatgg tgtccgaggc      300

taccccacca tcaagttctt caagaatgga gacacagctt cccccaaaga gtacacagct      360

ggccgagaag cggatgatat cgtgaactgg ctgaagaagc gcacgggccc cgctgccagc      420

acgctgtccg acggggctgc tgcagaggcc ttggtggagt ccagtgaggt ggccgtcatt      480

ggcttcttca aggacatgga gtcggactcc gcaaagcagt tcttgttggc agcagaggcc      540

attgatgaca tccccttcgg gatcacatct aacagcgatg tgttctccaa ataccagctg      600

gacaaggatg gggttgtcct ctttaagaag tttgacgaag gccggaacaa ctttgagggg      660

gaggtcacca aagaaaagct tctggacttc atcaagcaca accagttgcc cctggtcatt      720

gagttcaccg agcagacagc cccgaagatc ttcggagggg aaatcaagac tcacatcctg      780

ctgttcctgc cgaaaagcgt gtctgactat gagggcaagc tgagcaactt caaaaaagcg      840

gctgagagct tcaagggcaa gatcctgttt atcttcatcg acagcgacca cactgacaac      900

cagcgcatcc tggaattctt cggcctaaag aaagaggagt gcccggccgt gcgcctcatc      960

acgctggagg aggagatgac caaatataag ccagagtcag atgagctgac ggcagagaag     1020

atcaccgagt tctgccaccg cttcctggag ggcaagatta agccccacct gatgagccag     1080

gagctgcctg acgactggga caagcagcct gtcaaagtgc tggttgggaa gaactttgaa     1140

gaggttgctt ttgatgagaa aaagaacgtc tttgtagagt tctatgcccc gtggtgcggt     1200

cactgcaagc agctggcccc catctgggat aagctgggag agacgtacaa ggaccacgag     1260

aacatagtca tcgccaagat ggactccacg gccaacgagg tggaggcggt gaaagtgcac     1320

agcttcccca cgctcaagtt cttccccgcc agcgccgaca ggacggtcat cgactacaat     1380

ggggagcgga cactggatgg ttttaagaag ttcctggaga gtggtggcca ggatggggcc     1440

ggagatgatg acgatctaga agatcttgaa gaagcagaag agcctgatct ggaggaagat     1500

gatgatcaaa aagctgtgaa agatgaactg taa                                  1533


<210>  17
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: L-gulono, 1,4-lactone oxidase

<400>  17
atggtgcacg gctacaaggg cgtccagttt caaaactggg ctaagacgta tggatgttcc       60

ccagaggttt attaccagcc tacgtcagtc gaagaggtga gagaagtact ggcattggca      120

agggaacaaa agaaaaaagt gaaggtcgtg ggtggcggac atagtccatc cgacattgca      180

tgcactgacg gatttatgat ccatatggga aagatgaata gagtcttgca agtagataaa      240

gaaaaaaagc agattaccgt tgaagctggt atcctgctgg ctgatctgca tccccagctg      300

gatgaacatg gtcttgctat gtctaatcta ggcgccgtat ccgacgttac agttgctggt      360

gtgattggta gtggcaccca caacacggga ataaaacacg gaatactagc cacccaagta      420

gttgctctta ccttaatgac ggccgatggt gaagtcctgg agtgtagtga gtctagaaac      480

gccgacgtct ttcaagctgc ccgtgtgcat cttggttgct tgggcatcat cctaacagtc      540

acccttcaat gcgtccctca gtttcatcta caagaaactt ccttcccaag taccttaaag      600

gaggtcctag ataatttgga ttcacacctg aagagatcag agtatttcag gttcctgtgg      660

tttccacata cagagaacgt ttccatcatc tatcaagacc atacaaataa agcaccctcc      720

agtgcttcta actggttttg ggattatgca atcggttttt atctacttga atttttactg      780

tggacttcta cctacctacc ttgtttggtg ggttggataa accgtttctt tttttggatg      840

cttttcaatt gcaagaaaga gagttccaac ctatcccaca agatcttcac ttatgaatgc      900

cgttttaagc aacacgtgca agattgggca atcccaagag aaaagaccaa ggaggctctt      960

ttggagctaa aagcaatgct tgaggcacac cccaaggtag tggcccacta ccctgtagag     1020

gtcaggttca ccaggggcga tgatatattg ctgtcacctt gcttccagcg tgattcctgc     1080

tacatgaaca tcattatgta caggccctac ggcaaagacg tgccaagact agattactgg     1140

cttgcttacg agacgattat gaagaaattt ggaggtagac cccattgggc caaggctcac     1200

aactgtactc agaaggattt cgaggaaatg tatccaacct tccataaatt ttgcgacata     1260

agggaaaaac ttgaccctac aggcatgttc ctaaattctt accttgaaaa ggtcttttat     1320

taa                                                                   1323


<210>  18
<211>  1134
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: GDP-Mannose-3,5-epimerase, codon optimized 
       for Pichia

<400>  18
atgggcacca ccaatggtac agattatggc gcatatactt acaaggaatt ggaaagagag       60

cagtactggc cctctgagaa tctgaagatt tccataactg gtgcaggcgg atttatagca      120

tcccatattg caaggagatt aaaacacgag ggacactatg taatagcatc tgactggaaa      180

aagaacgagc acatgactga ggacatgttt tgcgacgaat ttcatcttgt tgacttaagg      240

gtcatggaaa attgccttaa agttactgag ggcgtagacc acgtctttaa ccttgccgcc      300

gacatgggcg gtatgggatt catccagtcc aatcattccg tgatcatgta caacaatacg      360

atgatcagtt tcaacatgat tgaagctgct agaatcaatg gaatcaagag attcttttac      420

gcatcttcag catgtatcta tccagaattt aagcaacttg aaaccactaa tgttagtctt      480

aaggaatccg acgcttggcc cgcagaacct caagatgcat atggtttgga gaaactggca      540

accgaagagc tatgcaaaca ttacaacaag gactttggta tcgagtgcag gattggcaga      600

ttccacaaca tatacggccc tttcggaact tggaaaggtg gcagagaaaa ggcccctgct      660

gctttctgta ggaaagcaca aacctccaca gataggtttg agatgtgggg cgatggccta      720

cagacaaggt cttttacttt cattgacgaa tgtgtcgaag gagttttgcg tttaactaag      780

agtgatttta gggagcctgt caatatagga tccgatgaga tggtgtccat gaacgagatg      840

gcagagatgg ttttatcttt tgaggagaaa aagctgccca tccatcatat tcccggtccc      900

gagggtgtca gaggcagaaa tagtgataat aacctaatca aggaaaaact tggttgggca      960

ccaaatatga gattgaaaga aggccttaga attacttact tctggataaa agaacaaatt     1020

gaaaaggaaa aggccaaggg tagtgatgtt agtctatacg gatcatctaa ggtcgttgga     1080

acgcaggccc cagtccaact gggaagtctt agagcagctg atggaaaaga ataa           1134


<210>  19
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: GDP-L-galactose phosphorylase

<400>  19
atgctgaaga tcaagagggt ccctactgtg gtgtcaaact accaaaaaga tgacggcgcc       60

gaagatcctg tcggatgtgg tagaaactgt cttggcgcat gttgcctgaa tggagcccgt      120

ctacctttat atgcctgtaa aaatttggta aaatcaggag aaaaattagt cattagtcac      180

gaggctatcg agccacccgt agcttttctt gagtcattgg ttctgggcga gtgggaggat      240

aggtttcaga gaggactgtt ccgttacgac gtcacggcat gcgagacaaa agtgataccc      300

ggaaaatatg gattcgttgc ccaactgaac gaaggcagac atctaaagaa gcgtccaacc      360

gaatttaggg tggataaagt attacaatct tttgatggct ctaaatttaa ttttactaaa      420

gttggacagg aagaactgct gtttcagttt gaagccggtg aagacgcaca ggtacagttt      480

tttccatgca tgccaataga tccagaaaat tcaccctctg tggtcgcaat aaatgtttcc      540

ccaatagaat atggacacgt tttacttatt cctagggtgt tggactgcct gccacaaagg      600

atcgaccaca agagtctttt gctggctgta catatggcag ctgaagctgc aaatccctac      660

ttccgtcttg gatacaattc tttgggtgcc tttgccacga tcaatcattt gcattttcaa      720

gcctactacc tggcaatgcc attcccatta gagaaagctc ctactaaaaa gattacgacc      780

accgtttcag gagtgaaaat atccgaactg ttaagttatc ccgtaagatc cctgctgttt      840

gaaggaggta gttccatgca agaattaagt gatacagtca gtgactgttg cgtgtgtcta      900

caaaataaca acataccatt taacatacta atctccgact gtggcaggca aatattttta      960

atgcctcaat gttatgccga aaaacaggcc ttaggagagg tgtcccctga agtgctagaa     1020

actcaggtga acccagccgt ttgggagatt tccggtcaca tggtccttaa aagaaaagaa     1080

gactacgaag gtgcctctga ggacaacgct tggcgtctac tagctgaggc tagtctaagt     1140

gaagaaagat tcaaggaagt tactgctcta gcattcgagg ccatcggctg ttccaatcaa     1200

gaggaagacc ttgaaggcac tatagtccac caacaaaaca gttctggaaa cgtgaaccaa     1260

aaatcaaaca gaacacacgg cggaccaatc accaatggta cggctgcaga gtgtttagtt     1320

ttacaataa                                                             1329


<210>  20
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: Inositol-phosphate phosphatase

<400>  20
atggccgaca atgattctct tgaccagttt ctggccgccg ccatcgacgc cgcaaaaaag       60

gcaggacaga ttattcgtaa gggattttat gaaaccaagc acgtcgagca taaaggtcag      120

gtcgatctag tgactgaaac ggataagggc tgtgaagaac tggtgttcaa tcatttaaaa      180

cagctattcc ccaatcataa gttcattggc gaagagacaa ctgctgcatt tggtgtaacg      240

gagctaactg atgagccaac ctggatcgta gatcccttag atggcaccac taatttcgta      300

catggttttc cttttgtgtg cgtatcaata ggtttaacca tcggtaaagt acctgtcgta      360

ggcgtcgttt acaatcccat tatggaagag ctttttacag gcgtccaagg aaaaggcgct      420

ttcttaaacg gaaaaaggat taaagtttct gcccagtcag agctattgac tgctctactt      480

gtcaccgagg caggtacaaa acgtgataaa gctactctgg atgatacaac caatcgtata      540

aactccctat tgactaaagt aaggagtctt cgtatgtcag gtagttgtgc cttagatttg      600

tgtggcgtag cctgcggaag ggtcgacatc ttctacgagt tgggtttcgg aggaccctgg      660

gacattgccg ccggaatagt gatcgtcaag gaagctggag gactaatctt cgatcctagt      720

ggtaaggatc tggacataac gtcacaaagg atcgcagcca gtaacgcatc cttaaaagag      780

ctatttgcag aagctctgag attgactgga gcctaa                                816


<210>  21
<211>  2746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: GDP-L-Gal phosphorylase from Arabidopsis 
       thaliana

<400>  21
ctggttcact catctcctat ctatttaaag cccattcgat atcctaaaac actgtatcat       60

caaaaaacac ctcaaagaat tattcattca ggcatcttct caaatttttg tttgtgaaaa      120

aaacccacat caaaagatct ctcatttatt cgtttcgttt ctgctgtttt gagtgtcggg      180

ttcgttttag ctgtaatctt tttttccggc gttcgatttg aaaaaatccg gggaacaggt      240

gatcggaatc acggctatac acgggatatc acggggtgtt agctcacatg tccatattgt      300

ccgacagaag ggttgtttaa tcgaaactaa tcctttgccg cacggaggac gtggagctct      360

gccgtctgaa ggcggcagcc cttccgatct cctctttctc gccggtggcg gttccagctt      420

taacttcttt tcctttaggt tttaggagtt agggtttgtt agtgtttttt ccttcttctt      480

tttttggtgc tcttgaatcg cttttttctt gggggaagtt ttttcttttg ctcttcgaaa      540

tttgtctttt ttgagaatgt tgaaaatcaa aagagttccg accgttgttt cgaactacca      600

gaaggacgat ggagcggagg atcccgtcgg ctgtggacgg aattgcctcg gcgcttgttg      660

ccttaacggt acgttttgga aacctgaatc gtctttttta atcatgttta aattttatca      720

cttttttttt attcacctta tgatgtgttt gttcaggggc taggcttcca ttgtatgcat      780

gtaagaatct ggtaaaatcc ggagagaagc ttgtaatcag tcatgaggct atagagcctc      840

ctgtagcttt tctcgagtcc cttgttctcg gagaggtaaa tcatagacca ctgattttga      900

tattctgata atggtttctg tagcttggaa gagtctaatc agtattctta tgtttagtgg      960

gaggataggt tccaaagagg actttttcgc tatgatgtca ctgcctgcga aaccaaagta     1020

attgtctttc ttaccttgtt tgacaatcta gttatgttgg gttgtttgtt gctgaggaat     1080

ccgagatatg ttttacattg ttcttaagat tgtttctctt gatgttatag gttatcccgg     1140

ggaagtatgg tttcgttgct cagcttaacg agggtcgtca cttgaagaag aggccaactg     1200

agttccgtgt agataaggtg ttgcagtctt ttgatggcag caaattcaac ttcactaaag     1260

ttggccaaga agagttgctc ttccagtttg aagctggtga agatgcccaa gttcagttct     1320

tcccttgcat gcctattgac cctgagaatt ctcccagtgt tgttgccatc aatgtaaaga     1380

ctcttgtgca gagagcttgg ttttttcttt cttcctttta ttggtttcgc tagcaaaaga     1440

ttaattcttt attgttgttt ttaacaggtt agtccgatag agtatggcca tgtgctgctg     1500

attcctcgtg ttcttgactg cttgcctcaa aggatcgatc acaaaagcct tttgcttgca     1560

gttcacatgg ctgctgaggc tgctaatcca tacttcagac tcggttacaa cagcttgggt     1620

gcttttgcca ctatcaatca tctccacttt caggtatatc caaaagtgat ccaagcataa     1680

ccttttcacc cttgctcatc taagatgttt gttctgattg ttttggtggt gattgttttt     1740

ggaaacaggc ttattacttg gccatgcctt tcccactgga gaaagctcct accaagaaga     1800

taactaccac tgttagtggt gtcaaaatct cagagcttct aagttaccct gtgagaagtc     1860

ttctctttga aggtggaagc tctatgcaag aactatctga tactgtttca gactgctgtg     1920

tttgccttca aaacaacaac attcctttca acattctcat ctctgattgt ggaaggcaga     1980

tcttcttaat gccacaggta tataactaca ccgttggatg aatacatgtt ttgaattact     2040

taatcaaaag tgaataacag tttgaatgta aaaattgcag tgttacgcag agaaacaggc     2100

tctaggtgaa gtgagcccgg aggtattgga aacacaagtg aacccagccg tgtgggagat     2160

aagtggtcac atggtactga agaggaaaga ggattacgaa ggtgcttcag aggataacgc     2220

gtggaggctc cttgcggaag cttctctgtc ggaggaaagg tttaaggagg ttactgctct     2280

cgcctttgaa gccataggtt gtagtaacca agaggaggat cttgaaggaa ccatagttca     2340

tcagcaaaac tctagtggca atgttaacca gaaaagcaac agaacccatg gaggtccgat     2400

cacaaatggg acggccgccg agtgccttgt ccttcagtga acaatatggt gacttggtgg     2460

tttgtatgta taattaaaag cctaaataag caaactctct ttgtagttgc atttgaagct     2520

tcttggttta tgtatgatgg ttgtgggcat tttgtgccta gacttctggt tctttgtttt     2580

ttgttatgag ttggtgttta tgaattatat atgttcttca ctaatatgat tattatttgt     2640

atagatttga ttattcaaag gatatgtctt aagaaggggt tcaggttcag ccaactaatt     2700

acttgtaacc aagtctttct accatcaaca accatgttaa gattca                    2746


<210>  22
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: GDP-L-Gal phosphorylase from Arabidopsis 
       thaliana

<400>  22

Met Leu Lys Ile Lys Arg Val Pro Thr Val Val Ser Asn Tyr Gln Lys 
1               5                   10                  15      


Asp Asp Gly Ala Glu Asp Pro Val Gly Cys Gly Arg Asn Cys Leu Gly 
            20                  25                  30          


Ala Cys Cys Leu Asn Gly Ala Arg Leu Pro Leu Tyr Ala Cys Lys Asn 
        35                  40                  45              


Leu Val Lys Ser Gly Glu Lys Leu Val Ile Ser His Glu Ala Ile Glu 
    50                  55                  60                  


Pro Pro Val Ala Phe Leu Glu Ser Leu Val Leu Gly Glu Trp Glu Asp 
65                  70                  75                  80  


Arg Phe Gln Arg Gly Leu Phe Arg Tyr Asp Val Thr Ala Cys Glu Thr 
                85                  90                  95      


Lys Val Ile Pro Gly Lys Tyr Gly Phe Val Ala Gln Leu Asn Glu Gly 
            100                 105                 110         


Arg His Leu Lys Lys Arg Pro Thr Glu Phe Arg Val Asp Lys Val Leu 
        115                 120                 125             


Gln Ser Phe Asp Gly Ser Lys Phe Asn Phe Thr Lys Val Gly Gln Glu 
    130                 135                 140                 


Glu Leu Leu Phe Gln Phe Glu Ala Gly Glu Asp Ala Gln Val Gln Phe 
145                 150                 155                 160 


Phe Pro Cys Met Pro Ile Asp Pro Glu Asn Ser Pro Ser Val Val Ala 
                165                 170                 175     


Ile Asn Val Ser Pro Ile Glu Tyr Gly His Val Leu Leu Ile Pro Arg 
            180                 185                 190         


Val Leu Asp Cys Leu Pro Gln Arg Ile Asp His Lys Ser Leu Leu Leu 
        195                 200                 205             


Ala Val His Met Ala Ala Glu Ala Ala Asn Pro Tyr Phe Arg Leu Gly 
    210                 215                 220                 


Tyr Asn Ser Leu Gly Ala Phe Ala Thr Ile Asn His Leu His Phe Gln 
225                 230                 235                 240 


Ala Tyr Tyr Leu Ala Met Pro Phe Pro Leu Glu Lys Ala Pro Thr Lys 
                245                 250                 255     


Lys Ile Thr Thr Thr Val Ser Gly Val Lys Ile Ser Glu Leu Leu Ser 
            260                 265                 270         


Tyr Pro Val Arg Ser Leu Leu Phe Glu Gly Gly Ser Ser Met Gln Glu 
        275                 280                 285             


Leu Ser Asp Thr Val Ser Asp Cys Cys Val Cys Leu Gln Asn Asn Asn 
    290                 295                 300                 


Ile Pro Phe Asn Ile Leu Ile Ser Asp Cys Gly Arg Gln Ile Phe Leu 
305                 310                 315                 320 


Met Pro Gln Cys Tyr Ala Glu Lys Gln Ala Leu Gly Glu Val Ser Pro 
                325                 330                 335     


Glu Val Leu Glu Thr Gln Val Asn Pro Ala Val Trp Glu Ile Ser Gly 
            340                 345                 350         


His Met Val Leu Lys Arg Lys Glu Asp Tyr Glu Gly Ala Ser Glu Asp 
        355                 360                 365             


Asn Ala Trp Arg Leu Leu Ala Glu Ala Ser Leu Ser Glu Glu Arg Phe 
    370                 375                 380                 


Lys Glu Val Thr Ala Leu Ala Phe Glu Ala Ile Gly Cys Ser Asn Gln 
385                 390                 395                 400 


Glu Glu Asp Leu Glu Gly Thr Ile Val His Gln Gln Asn Ser Ser Gly 
                405                 410                 415     


Asn Val Asn Gln Lys Ser Asn Arg Thr His Gly Gly Pro Ile Thr Asn 
            420                 425                 430         


Gly Thr Ala Ala Glu Cys Leu Val Leu Gln 
        435                 440         


<210>  23
<211>  1000
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic nucleotide: Inositol-phosphate phosphatase

<400>  23
gcctaaccac aaaaaccgta acttttggtt ttctctgaaa cacatcccaa agtaaagaaa       60

gcatcactct tttcgtcttc tctcgaaaat ggcggacaat gattctctag atcagttttt      120

ggctgccgcc attgatgccg ctaaaaaagc tggacagatc attcgtaaag ggttttacga      180

gactaaacat gttgaacaca aaggccaggt ggatttggtg acagagactg ataaaggatg      240

tgaagaactt gtgtttaatc atctcaagca gctctttccc aatcacaagt tcataggaga      300

agaaactaca gctgcatttg gtgtgacaga actaactgac gaaccaactt ggattgttga      360

tcctcttgat ggaacaacca atttcgttca cgggttccct ttcgtgtgtg tttccattgg      420

acttacgatt ggaaaagtcc ctgttgttgg agttgtttat aatcctatta tggaagagct      480

attcaccggt gtccaaggga aaggagcatt cttgaatgga aagcgaatca aagtgtcagc      540

tcaaagcgaa cttttaaccg ctttgctcgt gacagaggcg ggtactaaac gagataaagc      600

tacattagac gatacaacca acagaatcaa cagtttgcta accaaggtca ggtcccttag      660

gatgagtggt tcgtgtgcac tggacctctg tggcgttgcg tgtggaaggg ttgatatctt      720

ctacgagctc ggtttcggtg gtccatggga cattgcagca ggaattgtta tcgtgaaaga      780

agctggtgga ctcatctttg atccatccgg taaagatttg gacataacat cgcagaggat      840

cgcggcttca aacgcttctc tcaaggagtt attcgctgag gcgttgcggc ttacaggggc      900

atgaagtcat ctgttattat tttacaatat ggtctcaacc ttatatgatc aaactcaatt      960

caaaaactta acattattga atatttcttt tcggtagaaa                           1000


<210>  24
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: Inositol-phosphate phosphatase

<400>  24

Met Ala Asp Asn Asp Ser Leu Asp Gln Phe Leu Ala Ala Ala Ile Asp 
1               5                   10                  15      


Ala Ala Lys Lys Ala Gly Gln Ile Ile Arg Lys Gly Phe Tyr Glu Thr 
            20                  25                  30          


Lys His Val Glu His Lys Gly Gln Val Asp Leu Val Thr Glu Thr Asp 
        35                  40                  45              


Lys Gly Cys Glu Glu Leu Val Phe Asn His Leu Lys Gln Leu Phe Pro 
    50                  55                  60                  


Asn His Lys Phe Ile Gly Glu Glu Thr Thr Ala Ala Phe Gly Val Thr 
65                  70                  75                  80  


Glu Leu Thr Asp Glu Pro Thr Trp Ile Val Asp Pro Leu Asp Gly Thr 
                85                  90                  95      


Thr Asn Phe Val His Gly Phe Pro Phe Val Cys Val Ser Ile Gly Leu 
            100                 105                 110         


Thr Ile Gly Lys Val Pro Val Val Gly Val Val Tyr Asn Pro Ile Met 
        115                 120                 125             


Glu Glu Leu Phe Thr Gly Val Gln Gly Lys Gly Ala Phe Leu Asn Gly 
    130                 135                 140                 


Lys Arg Ile Lys Val Ser Ala Gln Ser Glu Leu Leu Thr Ala Leu Leu 
145                 150                 155                 160 


Val Thr Glu Ala Gly Thr Lys Arg Asp Lys Ala Thr Leu Asp Asp Thr 
                165                 170                 175     


Thr Asn Arg Ile Asn Ser Leu Leu Thr Lys Val Arg Ser Leu Arg Met 
            180                 185                 190         


Ser Gly Ser Cys Ala Leu Asp Leu Cys Gly Val Ala Cys Gly Arg Val 
        195                 200                 205             


Asp Ile Phe Tyr Glu Leu Gly Phe Gly Gly Pro Trp Asp Ile Ala Ala 
    210                 215                 220                 


Gly Ile Val Ile Val Lys Glu Ala Gly Gly Leu Ile Phe Asp Pro Ser 
225                 230                 235                 240 


Gly Lys Asp Leu Asp Ile Thr Ser Gln Arg Ile Ala Ala Ser Asn Ala 
                245                 250                 255     


Ser Leu Lys Glu Leu Phe Ala Glu Ala Leu Arg Leu Thr Gly Ala 
            260                 265                 270     


<210>  25
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: GDP-Mannose-3,5-epimerase

<400>  25

Met Gly Thr Thr Asn Gly Thr Asp Tyr Gly Ala Tyr Thr Tyr Lys Glu 
1               5                   10                  15      


Leu Glu Arg Glu Gln Tyr Trp Pro Ser Glu Asn Leu Lys Ile Ser Ile 
            20                  25                  30          


Thr Gly Ala Gly Gly Phe Ile Ala Ser His Ile Ala Arg Arg Leu Lys 
        35                  40                  45              


His Glu Gly His Tyr Val Ile Ala Ser Asp Trp Lys Lys Asn Glu His 
    50                  55                  60                  


Met Thr Glu Asp Met Phe Cys Asp Glu Phe His Leu Val Asp Leu Arg 
65                  70                  75                  80  


Val Met Glu Asn Cys Leu Lys Val Thr Glu Gly Val Asp His Val Phe 
                85                  90                  95      


Asn Leu Ala Ala Asp Met Gly Gly Met Gly Phe Ile Gln Ser Asn His 
            100                 105                 110         


Ser Val Ile Met Tyr Asn Asn Thr Met Ile Ser Phe Asn Met Ile Glu 
        115                 120                 125             


Ala Ala Arg Ile Asn Gly Ile Lys Arg Phe Phe Tyr Ala Ser Ser Ala 
    130                 135                 140                 


Cys Ile Tyr Pro Glu Phe Lys Gln Leu Glu Thr Thr Asn Val Ser Leu 
145                 150                 155                 160 


Lys Glu Ser Asp Ala Trp Pro Ala Glu Pro Gln Asp Ala Tyr Gly Leu 
                165                 170                 175     


Glu Lys Leu Ala Thr Glu Glu Leu Cys Lys His Tyr Asn Lys Asp Phe 
            180                 185                 190         


Gly Ile Glu Cys Arg Ile Gly Arg Phe His Asn Ile Tyr Gly Pro Phe 
        195                 200                 205             


Gly Thr Trp Lys Gly Gly Arg Glu Lys Ala Pro Ala Ala Phe Cys Arg 
    210                 215                 220                 


Lys Ala Gln Thr Ser Thr Asp Arg Phe Glu Met Trp Gly Asp Gly Leu 
225                 230                 235                 240 


Gln Thr Arg Ser Phe Thr Phe Ile Asp Glu Cys Val Glu Gly Val Leu 
                245                 250                 255     


Arg Leu Thr Lys Ser Asp Phe Arg Glu Pro Val Asn Ile Gly Ser Asp 
            260                 265                 270         


Glu Met Val Ser Met Asn Glu Met Ala Glu Met Val Leu Ser Phe Glu 
        275                 280                 285             


Glu Lys Lys Leu Pro Ile His His Ile Pro Gly Pro Glu Gly Val Arg 
    290                 295                 300                 


Gly Arg Asn Ser Asp Asn Asn Leu Ile Lys Glu Lys Leu Gly Trp Ala 
305                 310                 315                 320 


Pro Asn Met Arg Leu Lys Glu Gly Leu Arg Ile Thr Tyr Phe Trp Ile 
                325                 330                 335     


Lys Glu Gln Ile Glu Lys Glu Lys Ala Lys Gly Ser Asp Val Ser Leu 
            340                 345                 350         


Tyr Gly Ser Ser Lys Val Val Gly Thr Gln Ala Pro Val Gln Leu Gly 
        355                 360                 365             


Ser Leu Arg Ala Ala Asp Gly Lys Glu 
    370                 375         


<210>  26
<211>  610
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: L-gulono-1,4-lactone oxidase

<400>  26

Met Leu Arg Ser Leu Leu Leu Arg Arg Ser Val Gly His Ser Leu Gly 
1               5                   10                  15      


Thr Leu Ser Pro Ser Ser Ser Thr Ile Arg Ser Ser Phe Ser Pro His 
            20                  25                  30          


Arg Thr Leu Cys Thr Thr Gly Gln Thr Leu Thr Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Arg Pro Pro Pro Pro Pro Pro Ala Thr Ala Ser Glu Ala Gln 
    50                  55                  60                  


Phe Arg Lys Tyr Ala Gly Tyr Ala Ala Leu Ala Ile Phe Ser Gly Val 
65                  70                  75                  80  


Ala Thr Tyr Phe Ser Phe Pro Phe Pro Glu Asn Ala Lys His Lys Lys 
                85                  90                  95      


Ala Gln Ile Phe Arg Tyr Ala Pro Leu Pro Glu Asp Leu His Thr Val 
            100                 105                 110         


Ser Asn Trp Ser Gly Thr His Glu Val Gln Thr Arg Asn Phe Asn Gln 
        115                 120                 125             


Pro Glu Asn Leu Ala Asp Leu Glu Ala Leu Val Lys Glu Ser His Glu 
    130                 135                 140                 


Lys Lys Leu Arg Ile Arg Pro Val Gly Ser Gly Leu Ser Pro Asn Gly 
145                 150                 155                 160 


Ile Gly Leu Ser Arg Ser Gly Met Val Asn Leu Ala Leu Met Asp Lys 
                165                 170                 175     


Val Leu Glu Val Asp Lys Glu Lys Lys Arg Val Thr Val Gln Ala Gly 
            180                 185                 190         


Ile Arg Val Gln Gln Leu Val Asp Ala Ile Lys Asp Tyr Gly Leu Thr 
        195                 200                 205             


Leu Gln Asn Phe Ala Ser Ile Arg Glu Gln Gln Ile Gly Gly Ile Ile 
    210                 215                 220                 


Gln Val Gly Ala His Gly Thr Gly Ala Arg Leu Pro Pro Ile Asp Glu 
225                 230                 235                 240 


Gln Val Ile Ser Met Lys Leu Val Thr Pro Ala Lys Gly Thr Ile Glu 
                245                 250                 255     


Leu Ser Arg Glu Lys Asp Pro Glu Leu Phe His Leu Ala Arg Cys Gly 
            260                 265                 270         


Leu Gly Gly Leu Gly Val Val Ala Glu Val Thr Leu Gln Cys Val Ala 
        275                 280                 285             


Arg His Glu Leu Val Glu His Thr Tyr Val Ser Asn Leu Gln Glu Ile 
    290                 295                 300                 


Lys Lys Asn His Lys Lys Leu Leu Ser Ala Asn Lys His Val Lys Tyr 
305                 310                 315                 320 


Leu Tyr Ile Pro Tyr Thr Asp Thr Val Val Val Val Thr Cys Asn Pro 
                325                 330                 335     


Val Ser Lys Trp Ser Gly Pro Pro Lys Asp Lys Pro Lys Tyr Thr Thr 
            340                 345                 350         


Asp Glu Ala Val Gln His Val Arg Asp Leu Tyr Arg Glu Ser Ile Val 
        355                 360                 365             


Lys Tyr Arg Val Gln Asp Ser Gly Lys Lys Ser Pro Asp Ser Ser Glu 
    370                 375                 380                 


Pro Asp Ile Gln Glu Leu Ser Phe Thr Glu Leu Arg Asp Lys Leu Leu 
385                 390                 395                 400 


Ala Leu Asp Pro Leu Asn Asp Val His Val Ala Lys Val Asn Gln Ala 
                405                 410                 415     


Glu Ala Glu Phe Trp Lys Lys Ser Glu Gly Tyr Arg Val Gly Trp Ser 
            420                 425                 430         


Asp Glu Ile Leu Gly Phe Asp Cys Gly Gly Gln Gln Trp Val Ser Glu 
        435                 440                 445             


Ser Cys Phe Pro Ala Gly Thr Leu Ala Asn Pro Ser Met Lys Asp Leu 
    450                 455                 460                 


Glu Tyr Ile Glu Glu Leu Lys Lys Leu Ile Glu Lys Glu Ala Ile Pro 
465                 470                 475                 480 


Ala Pro Ala Pro Ile Glu Gln Arg Trp Thr Ala Arg Ser Lys Ser Pro 
                485                 490                 495     


Ile Ser Pro Ala Phe Ser Thr Ser Glu Asp Asp Ile Phe Ser Trp Val 
            500                 505                 510         


Gly Ile Ile Met Tyr Leu Pro Thr Ala Asp Pro Arg Gln Arg Lys Asp 
        515                 520                 525             


Ile Thr Asp Glu Phe Phe His Tyr Arg His Leu Thr Gln Lys Gln Leu 
    530                 535                 540                 


Trp Asp Gln Phe Ser Ala Tyr Glu His Trp Ala Lys Ile Glu Ile Pro 
545                 550                 555                 560 


Lys Asp Lys Glu Glu Leu Glu Ala Leu Gln Ala Arg Ile Arg Lys Arg 
                565                 570                 575     


Phe Pro Val Asp Ala Tyr Asn Lys Ala Arg Arg Glu Leu Asp Pro Asn 
            580                 585                 590         


Arg Ile Leu Ser Asn Asn Met Val Glu Lys Leu Phe Pro Val Ser Thr 
        595                 600                 605             


Thr Ala 
    610 


<210>  27
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Lys Ser Pro Ile Ser Pro Ala Phe Ser Thr Ser Glu Asp Asp Ile Phe 
1               5                   10                  15      


Ser Trp Val 
            


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Trp Tyr Asn His Val Pro Pro Asp Ser Arg Pro Ser Pro Glu Lys Gly 
1               5                   10                  15      


His His Arg 
            


<210>  29
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: D-glucuronokinase

<400>  29

Met Asp Pro Asn Ser Thr Val Ser Gly Asp Gly Gln Ala Thr Ala Ala 
1               5                   10                  15      


Ile Glu His Arg Ser Phe Ala Arg Ile Gly Phe Leu Gly Asn Pro Ser 
            20                  25                  30          


Asp Val Tyr Phe Gly Arg Thr Ile Ser Leu Thr Ile Gly Asn Phe Trp 
        35                  40                  45              


Ala Ser Val Lys Leu Glu Pro Ser Glu His Leu Val Ile Lys Pro His 
    50                  55                  60                  


Pro Phe His Asp Leu Val Gln Phe Thr Ser Leu Asp His Leu Leu Asn 
65                  70                  75                  80  


Arg Leu Gln Asn Glu Gly Tyr Tyr Gly Gly Val Arg Leu Leu Met Ala 
                85                  90                  95      


Ile Cys Lys Val Phe Arg Asn Tyr Cys Lys Glu Asn Asp Ile Gln Leu 
            100                 105                 110         


His Gln Ala Asn Phe Ser Leu Ser Tyr Asp Thr Asn Ile Pro Arg Gln 
        115                 120                 125             


Thr Gly Leu Ser Gly Ser Ser Ala Ile Val Ser Ala Ala Leu Asn Cys 
    130                 135                 140                 


Leu Leu Asp Phe Tyr Asn Val Arg His Leu Ile Lys Val Gln Val Arg 
145                 150                 155                 160 


Pro Asn Ile Val Leu Ser Ala Glu Lys Glu Leu Gly Ile Val Ala Gly 
                165                 170                 175     


Leu Gln Asp Arg Val Ala Gln Val Tyr Gly Gly Leu Val His Met Asp 
            180                 185                 190         


Phe Ser Lys Glu His Met Asp Lys Leu Gly His Gly Ile Tyr Thr Pro 
        195                 200                 205             


Met Asp Ile Ser Leu Leu Pro Pro Leu His Leu Ile Tyr Ala Glu Asn 
    210                 215                 220                 


Pro Ser Asp Ser Gly Lys Val His Ser Met Val Arg Gln Arg Trp Leu 
225                 230                 235                 240 


Asp Gly Asp Glu Phe Ile Ile Ser Ser Met Lys Glu Val Gly Ser Leu 
                245                 250                 255     


Ala Glu Glu Gly Arg Thr Ala Leu Leu Asn Lys Asp His Ser Lys Leu 
            260                 265                 270         


Val Glu Leu Met Asn Leu Asn Phe Asp Ile Arg Arg Arg Met Phe Gly 
        275                 280                 285             


Asp Glu Cys Leu Gly Ala Met Asn Ile Glu Met Val Glu Val Ala Arg 
    290                 295                 300                 


Arg Val Gly Ala Ala Ser Lys Phe Thr Gly Ser Gly Gly Ala Val Val 
305                 310                 315                 320 


Val Phe Cys Pro Glu Gly Pro Ser Gln Val Lys Leu Leu Glu Glu Glu 
                325                 330                 335     


Cys Arg Lys Ala Gly Phe Thr Leu Gln Pro Val Lys Ile Ala Pro Ser 
            340                 345                 350         


Cys Leu Asn Asp Ser Asp Ile Gln Thr Leu 
        355                 360         


<210>  30
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide: UDP-D-glucose dehydrogenase

<400>  30

Met Val Lys Ile Cys Cys Ile Gly Ala Gly Tyr Val Gly Gly Pro Thr 
1               5                   10                  15      


Met Ala Val Ile Ala Leu Lys Cys Pro Asp Ile Glu Val Ala Val Val 
            20                  25                  30          


Asp Ile Ser Val Pro Arg Ile Asn Ala Trp Asn Ser Asp Gln Leu Pro 
        35                  40                  45              


Ile Tyr Glu Pro Gly Leu Asp Asp Ile Val Lys Gln Cys Arg Gly Lys 
    50                  55                  60                  


Asn Leu Phe Phe Ser Thr Asp Val Glu Lys His Val Arg Glu Ala Asp 
65                  70                  75                  80  


Ile Val Phe Val Ser Val Asn Thr Pro Thr Lys Thr Thr Gly Leu Gly 
                85                  90                  95      


Ala Gly Lys Ala Ala Asp Leu Thr Tyr Trp Glu Ser Ala Ala Arg Met 
            100                 105                 110         


Ile Ala Asp Val Ser Val Ser Asp Lys Ile Val Val Glu Lys Ser Thr 
        115                 120                 125             


Val Pro Val Lys Thr Ala Glu Ala Ile Glu Lys Ile Leu Met His Asn 
    130                 135                 140                 


Ser Lys Gly Ile Lys Phe Gln Ile Leu Ser Asn Pro Glu Phe Leu Ala 
145                 150                 155                 160 


Glu Gly Thr Ala Ile Ala Asp Leu Phe Asn Pro Asp Arg Val Leu Ile 
                165                 170                 175     


Gly Gly Arg Glu Thr Pro Glu Gly Phe Lys Ala Val Gln Thr Leu Lys 
            180                 185                 190         


Glu Val Tyr Ala Asn Trp Val Pro Glu Gly Gln Ile Ile Thr Thr Asn 
        195                 200                 205             


Leu Trp Ser Ala Glu Leu Ser Lys Leu Ala Ala Asn Ala Phe Leu Ala 
    210                 215                 220                 


Gln Arg Ile Ser Ser Val Asn Ala Met Ser Ala Leu Cys Glu Ser Thr 
225                 230                 235                 240 


Gly Ala Asp Val Thr Gln Val Ser Tyr Ala Val Gly Thr Asp Ser Arg 
                245                 250                 255     


Ile Gly Ser Lys Phe Leu Asn Ala Ser Val Gly Phe Gly Gly Ser Cys 
            260                 265                 270         


Phe Gln Lys Asp Ile Leu Asn Leu Val Tyr Ile Cys Gln Cys Asn Gly 
        275                 280                 285             


Leu Pro Glu Val Ala Glu Tyr Trp Lys Gln Val Ile Lys Ile Asn Asp 
    290                 295                 300                 


Tyr Gln Lys Asn Arg Phe Val Asn Arg Ile Val Ser Ser Met Phe Asn 
305                 310                 315                 320 


Thr Val Ser Asn Lys Lys Val Ala Ile Leu Gly Phe Ala Phe Lys Lys 
                325                 330                 335     


Asp Thr Gly Asp Thr Arg Glu Thr Pro Ala Ile Asp Val Cys Lys Gly 
            340                 345                 350         


Leu Leu Gly Asp Lys Ala Gln Ile Ser Ile Tyr Asp Pro Gln Val Thr 
        355                 360                 365             


Glu Glu Gln Ile Gln Arg Asp Leu Ser Met Lys Lys Phe Asp Trp Asp 
    370                 375                 380                 


His Pro Leu His Leu Gln Pro Met Ser Pro Thr Thr Val Lys Gln Val 
385                 390                 395                 400 


Ser Val Thr Trp Asp Ala Tyr Glu Ala Thr Lys Asp Ala His Ala Val 
                405                 410                 415     


Cys Val Leu Thr Glu Trp Asp Glu Phe Lys Ser Leu Asp Tyr Gln Lys 
            420                 425                 430         


Ile Phe Asp Asn Met Gln Lys Pro Ala Phe Ile Phe Asp Gly Arg Asn 
        435                 440                 445             


Ile Met Asn Val Asn Lys Leu Arg Glu Ile Gly Phe Ile Val Tyr Ser 
    450                 455                 460                 


Ile Gly Lys Pro Leu Asp Pro Trp Leu Lys Asp Met Pro Ala Phe Val 
465                 470                 475                 480 


