                         SEQUENCE LISTING

<110>  Mersana Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE TO 
       NAPI2B-TARGETED THERAPY

<130>  MRSN-023/001WO

<150>  US 62/561,107
<151>  2017-09-20

<150>  US 62/571,397
<151>  2017-10-12

<150>  US 62/718,692
<151>  2018-08-14

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Thr Ala Arg Ala Thr Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly 
        115                 120 


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Gly Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Gly Tyr Thr Phe Thr Gly Tyr Asn Ile His 
1               5                   10  


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Lys Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Gly Glu Thr Ala Arg Ala Thr Phe Ala Tyr 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Ser Ala Ser Gln Asp Ile Gly Asn Phe Leu Asn 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Tyr Thr Ser Ser Leu Tyr Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Gln Gln Tyr Ser Lys Leu Pro Leu Thr 
1               5                   


<210>  9
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9
caagttcagc tggttcagtc tggcgccgag gttgtgaaac ctggcgcctc tgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc ggctacaaca tccactgggt caagcaggcc      120

cctggacagg gactcgaatg gatcggagcc atctatcccg gcaacggcga caccagctac      180

aagcagaagt tccggggcag agccacactg accgccgata caagcaccag caccgtgtac      240

atggaactga gcagcctgag aagcgaggac agcgccgtgt actattgcgc cagaggcgaa      300

acagccagag ccacctttgc ctattggggc cagggaaccc tggtcaccgt tagctct         357


<210>  10
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10
gatattcaga tgacacagag ccccagcagc ctgtctgcct ctgtgggaga cagagtgacc       60

atcacctgta gcgccagcca ggatatcggc aacttcctga actggtatca gcagaaaccc      120

ggcaagaccg tgaaggtgct gatctactac acctccagcc tgtacagcgg cgtgcccagc      180

agattttctg gcagcggctc tggcaccgac tacaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacagcaagc tgcccctgac atttggccag      300

ggcaccaagc tggaactgaa g                                                321


<210>  11
<211>  323
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  11

Gly Gln Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly 
1               5                   10                  15      


Asp Thr Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
            20                  25                  30          


Leu Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn 
        35                  40                  45              


Gly Val Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys 
65                  70                  75                  80  


Asn Val Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala 
                85                  90                  95      


Pro Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly 
            100                 105                 110         


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Glu 
    130                 135                 140                 


Asp Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val 
145                 150                 155                 160 


Arg Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile 
                165                 170                 175     


Arg Val Val Ser Thr Leu Pro Ile Ala His Glu Asp Trp Leu Arg Gly 
            180                 185                 190         


Lys Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile 
        195                 200                 205             


Glu Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val 
    210                 215                 220                 


Tyr Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser 
225                 230                 235                 240 


Leu Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu 
                245                 250                 255     


Trp Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala 
            260                 265                 270         


Val Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val 
        275                 280                 285             


Pro Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met 
    290                 295                 300                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser 
305                 310                 315                 320 


Pro Gly Lys 
            


<210>  12
<211>  104
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Arg Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp 
1               5                   10                  15      


Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr 
            20                  25                  30          


Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr 
        35                  40                  45              


Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr 
    50                  55                  60                  


Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser 
65                  70                  75                  80  


His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val 
                85                  90                  95      


Gln Ser Phe Asn Arg Gly Asp Cys 
            100                 


<210>  13
<211>  969
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  13
ggacagccta aggctcccag cgtgttccct ctggctcctt gctgtggcga tacccctagc       60

agcacagtga cactgggctg tctggtcaag ggctacctgc ctgaacctgt gaccgtgacc      120

tggaatagcg gcaccctgac caacggcgtg cggacatttc ctagcgtcag acagagcagc      180

ggcctgtact ctctgagcag cgtggtgtct gtgaccagca gctctcagcc tgtgacctgc      240

aatgtggccc atcctgccac caacaccaag gtggacaaaa ccgtggctcc ctccacctgt      300

agcaagccca catgtcctcc accagagctg ctcggaggcc cctccgtgtt tatcttccca      360

cctaagccta aggacaccct gatgatcagc agaacccctg aagtgacctg cgtggtggtg      420

gacgtgtccg aggatgatcc tgaggtgcag ttcacctggt acatcaacaa cgagcaagtg      480

cggaccgcca gacctcctct gagagagcag cagttcaaca gcaccatcag agtggtgtct      540

accctgccta tcgctcacga ggattggctg cggggcaaag agttcaagtg caaggtgcac      600

aacaaggccc tgcctgctcc tatcgagaaa accatctcca aggccagagg ccagccactg      660

gaacccaagg tgtacacaat gggccctcca agagaggaac tgtccagcag atccgtgtct      720

ctgacctgca tgatcaacgg cttctacccc agcgacatca gcgtggaatg ggagaagaat      780

ggcaaggccg aggacaacta caagacaacc cctgccgtgc tggatagcga cggcagctac      840

ttcctgtaca gcaagctgag cgtgcccacc tctgaatggc aacggggaga tgtgtttacc      900

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccat cagcaggtcc      960

ccaggcaaa                                                              969


<210>  14
<211>  312
<212>  DNA
<213>  Oryctolagus cuniculus

<400>  14
agggatcctg tggctcccac cgtgctgatt tttccaccag ccgctgatca ggtggccact       60

ggcacagtga caatcgtgtg cgtggccaac aagtacttcc ccgacgtgac cgtgacctgg      120

gaagtcgatg gcaccacaca gaccacaggc atcgagaaca gcaagacccc tcagaacagc      180

gccgactgca cctacaacct gagcagcacc ctgacactga ccagcacaca gtacaacagc      240

cacaaagagt acacctgtaa agtcacccag ggcacaacca gcgtggtgca gagcttcaac      300

agaggcgatt gc                                                          312


<210>  15
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Lys Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Glu Thr Ala Arg Ala Thr Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gln Pro Lys Ala Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Cys Gly Asp Thr Pro Ser Ser Thr Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Leu Pro Glu Pro Val Thr Val Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Thr Leu Thr Asn Gly Val Arg Thr Phe Pro Ser Val Arg 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Ser Val Thr Ser 
            180                 185                 190         


Ser Ser Gln Pro Val Thr Cys Asn Val Ala His Pro Ala Thr Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Thr Val Ala Pro Ser Thr Cys Ser Lys Pro Thr Cys 
    210                 215                 220                 


Pro Pro Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Val Ser Glu Asp Asp Pro Glu Val Gln Phe Thr Trp 
            260                 265                 270         


Tyr Ile Asn Asn Glu Gln Val Arg Thr Ala Arg Pro Pro Leu Arg Glu 
        275                 280                 285             


Gln Gln Phe Asn Ser Thr Ile Arg Val Val Ser Thr Leu Pro Ile Ala 
    290                 295                 300                 


His Glu Asp Trp Leu Arg Gly Lys Glu Phe Lys Cys Lys Val His Asn 
305                 310                 315                 320 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Arg Gly 
                325                 330                 335     


Gln Pro Leu Glu Pro Lys Val Tyr Thr Met Gly Pro Pro Arg Glu Glu 
            340                 345                 350         


Leu Ser Ser Arg Ser Val Ser Leu Thr Cys Met Ile Asn Gly Phe Tyr 
        355                 360                 365             


Pro Ser Asp Ile Ser Val Glu Trp Glu Lys Asn Gly Lys Ala Glu Asp 
    370                 375                 380                 


Asn Tyr Lys Thr Thr Pro Ala Val Leu Asp Ser Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Leu Tyr Ser Lys Leu Ser Val Pro Thr Ser Glu Trp Gln Arg Gly Asp 
                405                 410                 415     


Val Phe Thr Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            420                 425                 430         


Gln Lys Ser Ile Ser Arg Ser Pro Gly Lys 
        435                 440         


<210>  16
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Gly Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Thr Val Lys Val Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys Arg Asp Pro Val Ala 
            100                 105                 110         


Pro Thr Val Leu Ile Phe Pro Pro Ala Ala Asp Gln Val Ala Thr Gly 
        115                 120                 125             


Thr Val Thr Ile Val Cys Val Ala Asn Lys Tyr Phe Pro Asp Val Thr 
    130                 135                 140                 


Val Thr Trp Glu Val Asp Gly Thr Thr Gln Thr Thr Gly Ile Glu Asn 
145                 150                 155                 160 


Ser Lys Thr Pro Gln Asn Ser Ala Asp Cys Thr Tyr Asn Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn Ser His Lys Glu Tyr Thr 
            180                 185                 190         


Cys Lys Val Thr Gln Gly Thr Thr Ser Val Val Gln Ser Phe Asn Arg 
        195                 200                 205             


Gly Asp Cys 
    210     


<210>  17
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17
caagttcagc tggttcagtc tggcgccgag gttgtgaaac ctggcgcctc tgtgaagatg       60

agctgcaagg ccagcggcta caccttcacc ggctacaaca tccactgggt caagcaggcc      120

cctggacagg gactcgaatg gatcggagcc atctatcccg gcaacggcga caccagctac      180

aagcagaagt tccggggcag agccacactg accgccgata caagcaccag caccgtgtac      240

atggaactga gcagcctgag aagcgaggac agcgccgtgt actattgcgc cagaggcgaa      300

acagccagag ccacctttgc ctattggggc cagggaaccc tggtcaccgt tagctctgga      360

cagcctaagg ctcccagcgt gttccctctg gctccttgct gtggcgatac ccctagcagc      420

acagtgacac tgggctgtct ggtcaagggc tacctgcctg aacctgtgac cgtgacctgg      480

aatagcggca ccctgaccaa cggcgtgcgg acatttccta gcgtcagaca gagcagcggc      540

ctgtactctc tgagcagcgt ggtgtctgtg accagcagct ctcagcctgt gacctgcaat      600

gtggcccatc ctgccaccaa caccaaggtg gacaaaaccg tggctccctc cacctgtagc      660

aagcccacat gtcctccacc agagctgctc ggaggcccct ccgtgtttat cttcccacct      720

aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt ggtggtggac      780

gtgtccgagg atgatcctga ggtgcagttc acctggtaca tcaacaacga gcaagtgcgg      840

accgccagac ctcctctgag agagcagcag ttcaacagca ccatcagagt ggtgtctacc      900

ctgcctatcg ctcacgagga ttggctgcgg ggcaaagagt tcaagtgcaa ggtgcacaac      960

aaggccctgc ctgctcctat cgagaaaacc atctccaagg ccagaggcca gccactggaa     1020

cccaaggtgt acacaatggg ccctccaaga gaggaactgt ccagcagatc cgtgtctctg     1080

acctgcatga tcaacggctt ctaccccagc gacatcagcg tggaatggga gaagaatggc     1140

aaggccgagg acaactacaa gacaacccct gccgtgctgg atagcgacgg cagctacttc     1200

ctgtacagca agctgagcgt gcccacctct gaatggcaac ggggagatgt gtttacctgc     1260

agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccatcag caggtcccca     1320

ggcaaa                                                                1326


<210>  18
<211>  633
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18
gatattcaga tgacacagag ccccagcagc ctgtctgcct ctgtgggaga cagagtgacc       60

atcacctgta gcgccagcca ggatatcggc aacttcctga actggtatca gcagaaaccc      120

ggcaagaccg tgaaggtgct gatctactac acctccagcc tgtacagcgg cgtgcccagc      180

agattttctg gcagcggctc tggcaccgac tacaccctga ccatatctag cctgcagcct      240

gaggacttcg ccacctacta ctgccagcag tacagcaagc tgcccctgac atttggccag      300

ggcaccaagc tggaactgaa gagggatcct gtggctccca ccgtgctgat ttttccacca      360

gccgctgatc aggtggccac tggcacagtg acaatcgtgt gcgtggccaa caagtacttc      420

cccgacgtga ccgtgacctg ggaagtcgat ggcaccacac agaccacagg catcgagaac      480

agcaagaccc ctcagaacag cgccgactgc acctacaacc tgagcagcac cctgacactg      540

accagcacac agtacaacag ccacaaagag tacacctgta aagtcaccca gggcacaacc      600

agcgtggtgc agagcttcaa cagaggcgat tgc                                   633


