                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
 
<120>  Production of retinyl esters

<130>  32578-WO-PCT

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon optimized DmDGA1

<400>  1
atgaccacta acaaggaccc tcaggataag gagcccggta aggccgagca gcccactaag       60

aactctggtt cctccggtgt gggcattatg aagcgacttc gacgatctgc ctccgccact      120

gagcacaacc tttcttccct gcgaaaccga aagtccactc agaacctttt cgatcagcac      180

ggcaacccta ttgaccttcg acagtaccga aaggttcttg acaaggatga gaacggtaac      240

ggaaccaacg gctctgagaa gaagctccga taccgacgaa ctcagtctgt tacccgagct      300

gaggagattt ctaacaagga ggagaagcag cgacgagccc agcctggccg acctattcac      360

cgaccccgag attctctttt ctcttggtcc tctggattca ctaacttttc tggtctggtc      420

aactggggat tccttctcct ctgtatcgga ggtctgcgac ttggccttga gaaccttctc      480

aagtacggta tccgaatcaa ccctctcgat tggttcttct tcatttccgg acacaacgag      540

ggtgagggac acaacgctct gatcctgtcc atttactctc ttgttcacat ctccctctgt      600

cttgctgtcg agaagggtct ggctatggag attattgctg agggccttgg tctgttcatc      660

cagattgtga acattgttgt tctcgtttgt ctgcccgtgg ttactattca ccttaaggga      720

cacgcttttt ctcttatggg agcctctact gtttgcttct tttactctgt tctcttcctt      780

aagctctggt cttacgtgca gactaacatg tggtgccgac agacttacta ccagaagaac      840

ccccgagagc gacgaccttc cattactctc gccgagctta agaagggagt tcttaacgga      900

ggtgaggagg atgaggacgt ttccaagctg gttcagtacc ctgacaacct tacctacaag      960

gatctcctgt acttcctttg cgcccccact ctctgttacg agcttaactt ccctcgaact     1020

tcccgagtgc gaaagcgatt tctccttaag cgactccttg aggtggtcat tggtgtgaac     1080

gttgttatgg cccttttcca gcagtggatt atcccttctg tgcgaaactc ccttatcccc     1140

ttctctaaca tggacgtggc ccttgctact gagcgacttc tcaagctggc tctccctaac     1200

cacctttgct ggctctgctt tttctacctt atgttccact cttttctcaa cgctgtcggc     1260

gagcttctca actttgctga tcgaaacttt tactgtgatt ggtggaacgc taacaacatt     1320

gacaccttct ggcgaacttg gaacatgcct gttcaccgat ggtgcgtgcg acacctttac     1380

attcccgtgg ttcagatggg atactcttct cgacaggctt ccactattgt ctttctcttt     1440

tctgccgtct ttcacgagta ccttgtttct gttccccttc agatttacaa gatttgggct     1500

tttatgggca tgatgggtca gattcccctt tccgccattt ccaagtctat tgagaagaag     1560

ctcggccctc gaatgggaaa cattatcgtg tgggcttcca ttattcttgg tcagcctctc     1620

tgtatcatgg cttactacca cgattacgtc gttcagcact ttaagaactc cctcaacggc     1680

accgactact cttcctaa                                                   1698


<210>  2
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Yarrowia codon optimized YlDGA1

<400>  2
atgggtgatc gaggctcctc ccgacgacga cgaactggct cccgaccctc ctcccacggc       60

ggcggcggcc ctgccgccgc tgaggaggag gtgcgagatg ccgctgccgg ccccgacgtg      120

ggcgctgccg gcgacgcccc tgcccccgcc cccaacaagg atggcgacgc tggcgtgggc      180

tccggccact gggagctgcg atgccaccga ctccaggatt ctcttttctc ttccgactct      240

ggcttctcca actaccgagg catcctgaac tggtgtgtcg tgatgctgat cctttctaac      300

gcccgacttt tccttgagaa cctcatcaag tacggtatcc tggtcgatcc catccaggtc      360

gtttctctgt tcctgaagga cccttactcc tggcccgccc cttgcctggt tattgccgcc      420

aacgtttttg ccgttgctgc tttccaggtt gagaagcgac tggccgtggg tgccctgacc      480

gagcaggccg gactcctgct ccacgtggcc aacctcgcca ccattctgtg tttccctgcc      540

gctgtggttc ttctcgttga gtctattacc cctgtcggct ccctcctggc tctgatggcc      600

cacaccatcc tcttcctcaa gctgttctcc taccgagatg tcaactcttg gtgccgacga      660

gcccgagcca aggctgcctc tgctggcaag aaggcttcct ctgctgctgc cccccacact      720

gtctcctacc ccgacaacct tacctaccga gatctctact acttcctctt cgcccccact      780

ctctgctacg agctcaactt tccccgatcc ccccgaatcc gaaagcgatt cctccttcga      840

cgaatccttg agatgctctt tttcacccag ctccaggtgg gcctgatcca gcagtggatg      900

gtccccacca tccagaactc catgaagccc tttaaggaca tggactactc ccgaatcatc      960

gagcgactcc tgaagctggc cgtccctaac cacctcatct ggctcatctt cttctactgg     1020

ctgttccact cctgcctgaa cgctgtggcc gagctcatgc agtttggcga ccgagagttc     1080

taccgagact ggtggaactc cgagtctgtc acctacttct ggcagaactg gaacattccc     1140

gtgcacaagt ggtgcattcg acacttctac aagcccatgc ttcgacgagg ctcctctaag     1200

tggatggccc gaactggcgt gttcctggcc tccgccttct tccacgagta cctcgtgtcc     1260

gtccctctcc gaatgttccg actctgggcc ttcaccggca tgatggctca gatccctctc     1320

gcctggttcg tgggtcgatt cttccagggc aactacggta acgctgctgt gtggctgtcc     1380

ctcatcatcg gacagcctat tgccgtcctc atgtacgtcc acgactacta cgtgctcaac     1440

tacgaggctc ccgctgccga ggcttag                                         1467


<210>  3
<211>  565
<212>  PRT
<213>  Drosophila melanogaster

<400>  3

Met Thr Thr Asn Lys Asp Pro Gln Asp Lys Glu Pro Gly Lys Ala Glu 
1               5                   10                  15      


Gln Pro Thr Lys Asn Ser Gly Ser Ser Gly Val Gly Ile Met Lys Arg 
            20                  25                  30          


Leu Arg Arg Ser Ala Ser Ala Thr Glu His Asn Leu Ser Ser Leu Arg 
        35                  40                  45              


Asn Arg Lys Ser Thr Gln Asn Leu Phe Asp Gln His Gly Asn Pro Ile 
    50                  55                  60                  


Asp Leu Arg Gln Tyr Arg Lys Val Leu Asp Lys Asp Glu Asn Gly Asn 
65                  70                  75                  80  


Gly Thr Asn Gly Ser Glu Lys Lys Leu Arg Tyr Arg Arg Thr Gln Ser 
                85                  90                  95      


Val Thr Arg Ala Glu Glu Ile Ser Asn Lys Glu Glu Lys Gln Arg Arg 
            100                 105                 110         


Ala Gln Pro Gly Arg Pro Ile His Arg Pro Arg Asp Ser Leu Phe Ser 
        115                 120                 125             


Trp Ser Ser Gly Phe Thr Asn Phe Ser Gly Leu Val Asn Trp Gly Phe 
    130                 135                 140                 


Leu Leu Leu Cys Ile Gly Gly Leu Arg Leu Gly Leu Glu Asn Leu Leu 
145                 150                 155                 160 


Lys Tyr Gly Ile Arg Ile Asn Pro Leu Asp Trp Phe Phe Phe Ile Ser 
                165                 170                 175     


Gly His Asn Glu Gly Glu Gly His Asn Ala Leu Ile Leu Ser Ile Tyr 
            180                 185                 190         


Ser Leu Val His Ile Ser Leu Cys Leu Ala Val Glu Lys Gly Leu Ala 
        195                 200                 205             


Met Glu Ile Ile Ala Glu Gly Leu Gly Leu Phe Ile Gln Ile Val Asn 
    210                 215                 220                 


Ile Val Val Leu Val Cys Leu Pro Val Val Thr Ile His Leu Lys Gly 
225                 230                 235                 240 


His Ala Phe Ser Leu Met Gly Ala Ser Thr Val Cys Phe Phe Tyr Ser 
                245                 250                 255     


Val Leu Phe Leu Lys Leu Trp Ser Tyr Val Gln Thr Asn Met Trp Cys 
            260                 265                 270         


Arg Gln Thr Tyr Tyr Gln Lys Asn Pro Arg Glu Arg Arg Pro Ser Ile 
        275                 280                 285             


Thr Leu Ala Glu Leu Lys Lys Gly Val Leu Asn Gly Gly Glu Glu Asp 
    290                 295                 300                 


Glu Asp Val Ser Lys Leu Val Gln Tyr Pro Asp Asn Leu Thr Tyr Lys 
305                 310                 315                 320 


Asp Leu Leu Tyr Phe Leu Cys Ala Pro Thr Leu Cys Tyr Glu Leu Asn 
                325                 330                 335     


Phe Pro Arg Thr Ser Arg Val Arg Lys Arg Phe Leu Leu Lys Arg Leu 
            340                 345                 350         


Leu Glu Val Val Ile Gly Val Asn Val Val Met Ala Leu Phe Gln Gln 
        355                 360                 365             


Trp Ile Ile Pro Ser Val Arg Asn Ser Leu Ile Pro Phe Ser Asn Met 
    370                 375                 380                 


Asp Val Ala Leu Ala Thr Glu Arg Leu Leu Lys Leu Ala Leu Pro Asn 
385                 390                 395                 400 


His Leu Cys Trp Leu Cys Phe Phe Tyr Leu Met Phe His Ser Phe Leu 
                405                 410                 415     


Asn Ala Val Gly Glu Leu Leu Asn Phe Ala Asp Arg Asn Phe Tyr Cys 
            420                 425                 430         


Asp Trp Trp Asn Ala Asn Asn Ile Asp Thr Phe Trp Arg Thr Trp Asn 
        435                 440                 445             


Met Pro Val His Arg Trp Cys Val Arg His Leu Tyr Ile Pro Val Val 
    450                 455                 460                 


Gln Met Gly Tyr Ser Ser Arg Gln Ala Ser Thr Ile Val Phe Leu Phe 
465                 470                 475                 480 


Ser Ala Val Phe His Glu Tyr Leu Val Ser Val Pro Leu Gln Ile Tyr 
                485                 490                 495     


Lys Ile Trp Ala Phe Met Gly Met Met Gly Gln Ile Pro Leu Ser Ala 
            500                 505                 510         


Ile Ser Lys Ser Ile Glu Lys Lys Leu Gly Pro Arg Met Gly Asn Ile 
        515                 520                 525             


Ile Val Trp Ala Ser Ile Ile Leu Gly Gln Pro Leu Cys Ile Met Ala 
    530                 535                 540                 


Tyr Tyr His Asp Tyr Val Val Gln His Phe Lys Asn Ser Leu Asn Gly 
545                 550                 555                 560 


Thr Asp Tyr Ser Ser 
                565 


<210>  4
<211>  2090
<212>  DNA
<213>  Drosophila melanogaster

<400>  4
gcgtcagttg agaactcgtc gttgaagcgt gcggtttacg gtaaaaagag gccgcttcca       60

gtacgtgaaa ataagtctgc tcttgttgaa agaaacaaca aaaacttgcc aattggatta      120

aattgtgtgc aagagaccat caccatgacc accaataagg atccccaaga taaggagccc      180

gggaaagcag aacaaccgac caagaatagc ggatccagcg gtgtgggtat catgaagcgc      240

ttgagaagat cggcgtccgc cacagagcat aatcttagca gtctgcgaaa ccgcaagtca      300

acacaaaatc tattcgatca gcacgggaat cccatagatc tgcgacagta tcgtaaagtt      360

ttggataagg atgaaaatgg taatggaacc aacggatccg agaagaagct tagatacagg      420

agaacacaaa gtgtgactcg tgctgaggag atttccaata aagaggagaa gcagagaaga      480

gctcagcctg gcagaccaat ccatcggcca agagattctc tgttttcttg gagctctgga      540

tttaccaatt tttctggact ggtgaactgg ggatttctac tgctctgcat tggaggtctg      600

cgtttgggct tggagaatct cctaaagtat ggcattcgca tcaatccact ggattggttc      660

ttcttcataa gcggacacaa cgaaggcgaa ggacataacg ccctaatcct gagcatttac      720

tctttagtgc atatctcgct ctgtttggct gtggagaagg gtctagccat ggaaataatt      780

gcagagggct tgggcttgtt catccagata gtgaacattg ttgtcttggt ttgcctaccg      840

gtggtaacaa ttcacctaaa aggacatgct tttagtttga tgggcgcttc aacagtttgc      900

ttcttttact ctgtgttgtt cctaaaacta tggtcctatg tgcagacgaa tatgtggtgc      960

cgtcagactt attatcaaaa gaatccgcgg gagcgtcgac caagcataac tttggcggaa     1020

ctaaaaaaag gagttttgaa tggaggtgaa gaagacgagg acgtttccaa gctggtgcaa     1080

tatcctgata atctcacata caaggatctc ctgtacttcc tttgcgcgcc cactctctgc     1140

tatgagttga atttcccgcg aacttctcgc gtgcgcaaac gctttttgct gaagcgttta     1200

ttggaggtgg tgattggagt gaatgtggtt atggccttgt ttcaacaatg gatcattcca     1260

tcggttcgga actccctgat tccgttctcc aatatggacg tggccttagc cactgagcga     1320

cttcttaaac ttgcgctacc caatcatctt tgctggctct gctttttcta tctaatgttc     1380

cactcttttc ttaatgcggt cggcgaactg ctgaattttg cagatcgcaa tttttattgt     1440

gattggtgga atgcgaataa cattgacacc ttctggcgta catggaacat gccagttcat     1500

aggtggtgcg tgcgtcatct ctacatccct gtggtccaaa tgggatattc ctcaagacag     1560

gcctctacta ttgtctttct tttcagtgcc gtcttccatg aatatttggt ttcagttcct     1620

ttgcaaatat acaagatctg ggcatttatg ggcatgatgg gtcagattcc cctatcggcc     1680

atatccaaat ccattgaaaa gaaactgggt ccccgaatgg gcaatataat cgtgtgggct     1740

tccattattc ttggtcagcc tctgtgcata atggcctatt atcacgatta tgtcgtccag     1800

catttcaaaa actcgctcaa cggcaccgac tacagtagtt aggtttcaaa aaaggttaac     1860

atttaaaaat ggagcaacac tgaaatatct gcatcggtcg ggtccgtgta cttttcgtaa     1920

tttataagcc agaatgcaag ttaagaagga aacttgtgat tgccaattta caaagcatat     1980

tttgtatgac ttttgcacat gcatgtagta ctgattaaca caaatagatt gttattgaat     2040

gcatttgtta atgaatttaa gtgtcatgta aataaatcaa attttaaact                2090


<210>  5
<211>  526
<212>  PRT
<213>  Yarrowia lipolytica

<400>  5

Met Glu Val Arg Arg Arg Lys Ile Asp Val Leu Lys Ala Gln Lys Asn 
1               5                   10                  15      


Gly Tyr Glu Ser Gly Pro Pro Ser Arg Gln Ser Ser Gln Pro Ser Ser 
            20                  25                  30          


Arg Ala Ser Ser Arg Thr Arg Asn Lys His Ser Ser Ser Thr Leu Ser 
        35                  40                  45              


Leu Ser Gly Leu Thr Met Lys Val Gln Lys Lys Pro Ala Gly Pro Pro 
    50                  55                  60                  


Ala Asn Ser Lys Thr Pro Phe Leu His Ile Lys Pro Val His Thr Cys 
65                  70                  75                  80  


Cys Ser Thr Ser Met Leu Ser Arg Asp Tyr Asp Gly Ser Asn Pro Ser 
                85                  90                  95      


Phe Lys Gly Phe Lys Asn Ile Gly Met Ile Ile Leu Ile Val Gly Asn 
            100                 105                 110         


Leu Arg Leu Ala Phe Glu Asn Tyr Leu Lys Tyr Gly Ile Ser Asn Pro 
        115                 120                 125             


Phe Phe Asp Pro Lys Ile Thr Pro Ser Glu Trp Gln Leu Ser Gly Leu 
    130                 135                 140                 


Leu Ile Val Val Ala Tyr Ala His Ile Leu Met Ala Tyr Ala Ile Glu 
145                 150                 155                 160 


Ser Ala Ala Lys Leu Leu Phe Leu Ser Ser Lys His His Tyr Met Ala 
                165                 170                 175     


Val Gly Leu Leu His Thr Met Asn Thr Leu Ser Ser Ile Ser Leu Leu 
            180                 185                 190         


Ser Tyr Val Val Tyr Tyr Tyr Leu Pro Asn Pro Val Ala Gly Thr Ile 
        195                 200                 205             


Val Glu Phe Val Ala Val Ile Leu Ser Leu Lys Leu Ala Ser Tyr Ala 
    210                 215                 220                 


Leu Thr Asn Ser Asp Leu Arg Lys Ala Ala Ile His Ala Gln Lys Leu 
225                 230                 235                 240 


Asp Lys Thr Gln Asp Asp Asn Glu Lys Glu Ser Thr Ser Ser Ser Ser 
                245                 250                 255     


Ser Ser Asp Asp Ala Glu Thr Leu Ala Asp Ile Asp Val Ile Pro Ala 
            260                 265                 270         


Tyr Tyr Ala Gln Leu Pro Tyr Pro Gln Asn Val Thr Leu Ser Asn Leu 
        275                 280                 285             


Leu Tyr Phe Trp Phe Ala Pro Thr Leu Val Tyr Gln Pro Val Tyr Pro 
    290                 295                 300                 


Lys Thr Glu Arg Ile Arg Pro Lys His Val Ile Arg Asn Leu Phe Glu 
305                 310                 315                 320 


Leu Val Ser Leu Cys Met Leu Ile Gln Phe Leu Ile Phe Gln Tyr Ala 
                325                 330                 335     


Tyr Pro Ile Met Gln Ser Cys Leu Ala Leu Phe Phe Gln Pro Lys Leu 
            340                 345                 350         


Asp Tyr Ala Asn Ile Ser Glu Arg Leu Met Lys Leu Ala Ser Val Ser 
        355                 360                 365             


Met Met Val Trp Leu Ile Gly Phe Tyr Ala Phe Phe Gln Asn Gly Leu 
    370                 375                 380                 


Asn Leu Ile Ala Glu Leu Thr Cys Phe Gly Asn Arg Thr Phe Tyr Gln 
385                 390                 395                 400 


Gln Trp Trp Asn Ser Arg Ser Ile Gly Gln Tyr Trp Thr Leu Trp Asn 
                405                 410                 415     


Lys Pro Val Asn Gln Tyr Phe Arg His His Val Tyr Val Pro Leu Leu 
            420                 425                 430         


Ala Arg Gly Met Ser Arg Phe Asn Ala Ser Val Val Val Phe Phe Phe 
        435                 440                 445             


Ser Ala Val Ile His Glu Leu Leu Val Gly Ile Pro Thr His Asn Ile 
    450                 455                 460                 


Ile Gly Ala Ala Phe Phe Gly Met Met Ser Gln Val Pro Leu Ile Met 
465                 470                 475                 480 


Ala Thr Glu Asn Leu Gln His Ile Asn Ser Ser Leu Gly Pro Phe Leu 
                485                 490                 495     


Gly Asn Cys Ala Phe Trp Phe Thr Phe Phe Leu Gly Gln Pro Thr Cys 
            500                 505                 510         


Ala Phe Leu Tyr Tyr Leu Ala Tyr Asn Tyr Lys Gln Asn Gln 
        515                 520                 525     


<210>  6
<211>  1581
<212>  DNA
<213>  Yarrowia lipolytica

<400>  6
atggaagtcc gacgacgaaa aatcgacgtg ctcaaggccc agaaaaacgg ctacgaatcg       60

ggcccaccat ctcgacaatc gtcgcagccc tcctcaagag catcgtccag aacccgcaac      120

aaacactcct cgtccaccct gtcgctcagc ggactgacca tgaaagtcca gaagaaacct      180

gcgggacccc cggcgaactc caaaacgcca ttcctacaca tcaagcccgt gcacacgtgc      240

tgctccacat caatgctttc gcgcgattat gacggctcca accccagctt caagggcttc      300

aaaaacatcg gcatgatcat tctcattgtg ggaaatctac ggctcgcatt cgaaaactac      360

ctcaaatacg gcatttccaa cccgttcttc gaccccaaaa ttactccttc cgagtggcag      420

ctctcaggct tgctcatagt cgtggcctac gcacatatcc tcatggccta cgctattgag      480

agcgctgcca agctgctgtt cctctctagc aaacaccact acatggccgt ggggcttctg      540

cataccatga acactttgtc gtccatctcg ttgctgtcct acgtcgtcta ctactacctg      600

cccaaccccg tggcaggcac aatagtcgag tttgtggccg ttattctgtc tctcaaactc      660

gcctcatacg ccctcactaa ctcggatctc cgaaaagccg caattcatgc ccagaagctc      720

gacaagacgc aagacgataa cgaaaaggaa tccacctcgt cttcctcttc ttcagatgac      780

gcagagactt tggcagacat tgacgtcatt cctgcatact acgcacagct gccctacccc      840

cagaatgtga cgctgtcgaa cctgctgtac ttctggtttg ctcccacact ggtctaccag      900

cccgtgtacc ccaagacgga gcgtattcga cccaagcacg tgatccgaaa cctgtttgag      960

ctcgtctctc tgtgcatgct tattcagttt ctcatcttcc agtacgccta ccccatcatg     1020

cagtcgtgtc tggctctgtt cttccagccc aagctcgatt atgccaacat ctccgagcgc     1080

ctcatgaagt tggcctccgt gtctatgatg gtctggctca ttggattcta cgctttcttc     1140

cagaacggtc tcaatcttat tgccgagctc acctgttttg gaaacagaac cttctaccag     1200

cagtggtgga attcccgctc cattggccag tactggactc tatggaacaa gccagtcaac     1260

cagtacttta gacaccacgt ctacgtgcct cttctcgctc ggggcatgtc gcggttcaat     1320

gcgtcggtgg tggttttctt tttctccgcc gtcatccatg aactgcttgt cggcatcccc     1380

actcacaaca tcatcggagc cgccttcttc ggcatgatgt cgcaggtgcc tctgatcatg     1440

gctactgaga accttcagca tattaactcc tctctgggcc ccttccttgg caactgtgca     1500

ttctggttca cctttttcct gggacaaccc acttgtgcat tcctttatta tctggcttac     1560

aactacaagc agaaccagta g                                               1581


<210>  7
<211>  648
<212>  PRT
<213>  Yarrowia lipolytica

<400>  7

Met Thr Gln Pro Val Asn Arg Lys Ala Thr Val Glu Arg Val Glu Pro 
1               5                   10                  15      


Ala Val Glu Val Ala Asp Ser Glu Ser Glu Ala Lys Thr Asp Val His 
            20                  25                  30          


Val His His His His His His His Lys Arg Lys Ser Val Lys Gly Lys 
        35                  40                  45              


Ile Leu Asn Phe Phe Thr Arg Ser Arg Arg Ile Thr Phe Val Leu Gly 
    50                  55                  60                  


Ala Val Val Gly Val Ile Ala Ala Gly Tyr Tyr Ala Ala Pro Pro Glu 
65                  70                  75                  80  


Leu Ser Ile Asp Ile Asp Ala Leu Leu Gly Asp Leu Pro Ser Phe Asp 
                85                  90                  95      


Phe Asp Ala Leu Ser Leu Asp Asn Leu Ser Met Asp Ser Val Ser Asp 
            100                 105                 110         


Phe Val Gln Asp Met Lys Ser Arg Phe Pro Thr Lys Ile Leu Gln Glu 
        115                 120                 125             


Ala Ala Lys Ile Glu Lys His Gln Lys Ser Glu Gln Lys Ala Ala Pro 
    130                 135                 140                 


Phe Ala Val Gly Lys Ala Met Lys Ser Glu Gly Leu Asn Ala Lys Tyr 
145                 150                 155                 160 


Pro Val Val Leu Val Pro Gly Val Ile Ser Thr Gly Leu Glu Ser Trp 
                165                 170                 175     


Ser Leu Glu Gly Thr Glu Glu Cys Pro Thr Glu Ser His Phe Arg Lys 
            180                 185                 190         


Arg Met Trp Gly Ser Trp Tyr Met Ile Arg Val Met Leu Leu Asp Lys 
        195                 200                 205             


Tyr Cys Trp Leu Gln Asn Leu Met Leu Asp Thr Glu Thr Gly Leu Asp 
    210                 215                 220                 


Pro Pro His Phe Lys Leu Arg Ala Ala Gln Gly Phe Ala Ser Ala Asp 
225                 230                 235                 240 


Phe Phe Met Ala Gly Tyr Trp Leu Trp Asn Lys Leu Leu Glu Asn Leu 
                245                 250                 255     


Ala Val Ile Gly Tyr Asp Thr Asp Thr Met Ser Ala Ala Ala Tyr Asp 
            260                 265                 270         


Trp Arg Leu Ser Tyr Pro Asp Leu Glu His Arg Asp Gly Tyr Phe Ser 
        275                 280                 285             


Lys Leu Lys Ala Ser Ile Glu Glu Thr Lys Arg Met Thr Gly Glu Lys 
    290                 295                 300                 


Thr Val Leu Thr Gly His Ser Met Gly Ser Gln Val Ile Phe Tyr Phe 
305                 310                 315                 320 


Met Lys Trp Ala Glu Ala Glu Gly Tyr Gly Gly Gly Gly Pro Asn Trp 
                325                 330                 335     


Val Asn Asp His Ile Glu Ser Phe Val Asp Ile Ser Gly Ser Met Leu 
            340                 345                 350         


Gly Thr Pro Lys Thr Leu Val Ala Leu Leu Ser Gly Glu Met Lys Asp 
        355                 360                 365             


Thr Val Gln Leu Asn Ala Met Ala Val Tyr Gly Leu Glu Gln Phe Phe 
    370                 375                 380                 


Ser Arg Arg Glu Arg Ala Asp Leu Leu Arg Thr Trp Gly Gly Ile Ala 
385                 390                 395                 400 


Ser Met Ile Pro Lys Gly Gly Lys Ala Ile Trp Gly Asp His Ser Gly 
                405                 410                 415     


Ala Pro Asp Asp Glu Pro Gly Gln Asn Val Thr Phe Gly Asn Phe Ile 
            420                 425                 430         


Lys Phe Lys Glu Ser Leu Thr Glu Tyr Ser Ala Lys Asn Leu Thr Met 
        435                 440                 445             


Asp Glu Thr Val Asp Phe Leu Tyr Ser Gln Ser Pro Glu Trp Phe Val 
    450                 455                 460                 


Asn Arg Thr Glu Gly Ala Tyr Ser Phe Gly Ile Ala Lys Thr Arg Lys 
465                 470                 475                 480 


Gln Val Glu Gln Asn Glu Lys Arg Pro Ser Thr Trp Ser Asn Pro Leu 
                485                 490                 495     


Glu Ala Ala Leu Pro Asn Ala Pro Asp Leu Lys Ile Tyr Cys Phe Tyr 
            500                 505                 510         


Gly Val Gly Lys Asp Thr Glu Arg Ala Tyr Tyr Tyr Gln Asp Glu Pro 
        515                 520                 525             


Asn Pro Glu Gln Thr Asn Leu Asn Val Ser Ile Ala Gly Asn Asp Pro 
    530                 535                 540                 


Asp Gly Val Leu Met Gly Gln Gly Asp Gly Thr Val Ser Leu Val Thr 
545                 550                 555                 560 


His Thr Met Cys His Arg Trp Lys Asp Glu Asn Ser Lys Phe Asn Pro 
                565                 570                 575     


Gly Asn Ala Gln Val Lys Val Val Glu Met Leu His Gln Pro Asp Arg 
            580                 585                 590         


Leu Asp Ile Arg Gly Gly Ala Gln Thr Ala Glu His Val Asp Ile Leu 
        595                 600                 605             


Gly Arg Ser Glu Leu Asn Glu Met Val Leu Lys Val Ala Ser Gly Lys 
    610                 615                 620                 


Gly Asn Glu Ile Glu Glu Arg Val Ile Ser Asn Ile Asp Glu Trp Val 
625                 630                 635                 640 


Trp Lys Ile Asp Leu Gly Ser Asn 
                645             


<210>  8
<211>  1947
<212>  DNA
<213>  Yarrowia lipolytica

<400>  8
atgacacaac ctgtgaatcg gaaggcgact gtcgagcggg tcgagccagc agtggaggtg       60

gctgactccg agtccgaggc caagaccgac gtccacgttc accaccatca tcaccaccac      120

aagcgaaaat ccgtcaaggg caagattctc aacttcttca cccgaagtcg acgtatcacc      180

ttcgtcctcg gcgccgtggt cggtgtgata gccgcgggat actacgctgc gccaccggag      240

ctcagcattg atatcgatgc tcttctcggc gacttgccct cgttcgactt tgacgctcta      300

tctctcgaca acttgtccat ggacagtgtg tcggactttg tacaagacat gaaatcgcgg      360

tttccgacca agattctgca ggaggcggcc aagatcgaga agcaccagaa aagcgaacag      420

aaggctgccc cttttgctgt gggcaaggct atgaagagcg agggactcaa cgccaagtac      480

ccggtggtgc tggtgcccgg cgtcatctcc acgggactgg agagctggtc cctggaggga      540

accgaggagt gtcccaccga gtcgcacttc agaaagcgaa tgtggggctc ctggtacatg      600

atccgagtca tgctgctgga caagtactgc tggctgcaga acctgatgct ggacacagag      660

accggtctag accctcccca tttcaagctg cgagccgccc agggatttgc ctccgccgac      720

ttctttatgg caggctactg gctgtggaac aagctgctcg agaacctggc tgttattgga      780

tacgatacgg atacaatgtc tgctgcggcg tacgactgga gactgtccta ccctgatttg      840

gagcaccgag acggatactt ctccaagctc aaagcttcaa tcgaagagac taagcgtatg      900

acaggtgaga agacagttct gacgggccat tccatgggct cccaggtcat cttctacttc      960

atgaagtggg ctgaggccga gggatatgga ggaggaggtc ccaactgggt caatgaccat     1020

attgaatcct ttgtcgacat ttccggctcc atgctgggta ctcccaagac cctggttgct     1080

cttctgtctg gagaaatgaa ggataccgtg cagctgaacg cgatggctgt gtatggactg     1140

gagcagttct tctctcgacg agagcgagcc gatctgctgc gaacatgggg aggaattgct     1200

tccatgattc ccaagggtgg taaggctatc tggggtgatc attctggagc ccctgatgac     1260

gagcctggcc agaatgtcac ctttggcaac ttcatcaagt tcaaggagtc cttgaccgag     1320

tactctgcta agaacctcac catggatgaa accgttgact tcctgtattc tcagtctccc     1380

gagtggtttg tgaaccgaac cgagggtgct tactcctttg gaattgccaa gactcgaaag     1440

caggttgagc agaatgagaa gcgaccttct acctggagca accctctgga agctgctctc     1500

cccaatgccc ccgatctcaa gatctactgc ttctatggag tcggtaagga taccgagcga     1560

gcctactact accaggatga gcccaatccc gagcagacca acttgaacgt cagtatcgct     1620

ggaaacgacc ctgatggtgt gcttatgggc cagggcgatg gaaccgtctc ccttgtgacc     1680

cataccatgt gtcaccgatg gaaggacgag aattccaagt tcaaccctgg taacgcccag     1740

gtcaaggttg tggagatgtt gcaccagcct gatcgacttg atattcgagg cggtgctcag     1800

actgccgagc atgtggacat tctggggcgt tctgagttga acgagatggt tctgaaggtg     1860

gccagtggaa agggaaatga gattgaagag agagtcatct ccaacattga tgagtgggtg     1920

tggaagattg atctcggcag caattag                                         1947


<210>  9
<211>  325
<212>  PRT
<213>  Fusarium oxysporum

<400>  9

Met Thr Thr Lys Tyr Thr Ser Val His Glu Ser Pro Asn Gly Pro Gly 
1               5                   10                  15      


Asp Ala Arg Pro Thr Ala Ser Gln Ile Ile Asp Asp Tyr Asn Leu Glu 
            20                  25                  30          


Gly Glu Leu Ser Gly Lys Thr Val Leu Val Thr Gly Cys Ser Ser Gly 
        35                  40                  45              


Ile Gly Val Glu Thr Ala Arg Ala Ile Tyr Arg Thr Gly Ala Thr Leu 
    50                  55                  60                  


Tyr Leu Thr Ala Arg Asp Val Asp Lys Ala Lys Thr Val Leu Pro Asp 
65                  70                  75                  80  


Leu Val Asp Thr Ser Arg Val His Phe Leu His Leu Asp Leu Asn Ser 
                85                  90                  95      


Leu Glu Ser Val Arg Gly Phe Ala Glu Asn Phe Lys Ser Lys Ser Thr 
            100                 105                 110         


Gln Leu His Ile Leu Ile Glu Asn Ala Gly Val Met Ala Cys Pro Glu 
        115                 120                 125             


Gly Arg Thr Val Asp Gly Phe Glu Thr Gln Phe Gly Ile Asn His Leu 
    130                 135                 140                 


Ala His Phe Leu Leu Phe Tyr Leu Leu Lys Asp Thr Leu Leu Asn Ser 
145                 150                 155                 160 


Ser Thr Pro Ala Phe Asn Ser Arg Val Val Ile Leu Ser Ser Cys Ala 
                165                 170                 175     


His Gln Ala Gly Ser Val His Leu Asn Asn Leu Ser Leu Glu Gly Gly 
            180                 185                 190         


Tyr Glu Pro Trp Lys Ser Tyr Gly Gln Ser Lys Thr Ala Asn Leu Trp 
        195                 200                 205             


Thr Ala Arg Glu Ile Glu Lys Arg Phe Gly Ala Ser Gly Ile His Ser 
    210                 215                 220                 


Trp Ala Val His Pro Gly Ser Ile Ala Thr Glu Leu Gln Arg His Val 
225                 230                 235                 240 


Ser Asp Glu Leu Lys Gln Lys Trp Ala Asp Asp Lys Glu Gly Ala Lys 
                245                 250                 255     


Leu Trp Lys Ser Thr Glu Gln Gly Ala Ala Thr Thr Val Leu Ala Ala 
            260                 265                 270         


Val Ser Pro Glu Leu Glu Gly Lys Gly Gly Leu Tyr Leu Glu Asp Thr 
        275                 280                 285             


Gln Val Ala Lys Pro Pro Ala Arg Gly Met Phe Gly Val Ala Asp Trp 
    290                 295                 300                 


Ala Tyr Asp Glu Asp Gly Pro Ser Lys Leu Trp Ala Lys Ser Leu Glu 
305                 310                 315                 320 


Leu Leu Lys Leu Gln 
                325 


<210>  10
<211>  978
<212>  DNA
<213>  Fusarium oxysporum

<400>  10
atgacaacta agtacacttc ggttcacgaa agccccaacg ggcctggtga tgcgcgtccc       60

accgcttccc aaatcattga cgactataat ttagaaggag aactgtctgg caagacagtt      120

ctcgtcaccg gctgctcatc tggtattggt gttgagaccg cgcgtgcaat ctatagaaca      180

ggtgccacac tctatttgac agctcgagat gtcgacaagg ccaagacggt actgcctgat      240

ttggtagaca cttctcgcgt ccatttcctt caccttgact tgaattctct ggagtcagta      300

cgtggttttg cggaaaactt caagtcaaag agcacccaac tacatattct catcgagaac      360

gctggcgtga tggcatgccc cgagggccgt acggtggatg gatttgagac tcaatttggt      420

atcaaccacc tagctcattt cctcctcttc tatctcctca aggatacctt gctcaactct      480

tcaacgcccg ctttcaactc tcgggttgtc atcctctctt cttgtgccca tcaagcgggt      540

tcggttcact tgaataacct gagtcttgag ggagggtatg agccatggaa atcgtacggc      600

cagagcaaaa cggccaatct ctggacagca cgcgagattg agaagcgttt tggagcaagc      660

ggtatccact catgggctgt tcaccccgga agcatcgcaa cagaactgca gcgacatgtg      720

tcggacgagc ttaaacagaa gtgggcagat gataaagaag gtgccaagtt atggaaaagc      780

accgagcagg gtgcggcgac cactgtcttg gcagctgtat cgccagagct tgaaggcaaa      840

ggcgggcttt atttggagga cactcaagtt gccaagcctc cagcaagggg aatgtttggt      900

gttgcagact gggcttacga cgaagatggg ccgtctaagc tctgggccaa gagtcttgag      960

cttttgaagc tgcaatga                                                    978


