                         SEQUENCE LISTING

<110>  Inserm
 
<120>  USE OF VNN1 AS A BIOMARKER AND A THERAPEUTIC TARGET IN SARCOMAS

<130>  BIO17350 NAQUET /MC

<160>  2     

<170>  PatentIn version 3.3

<210>  1
<211>  513
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Thr Gln Leu Pro Ala Tyr Val Ala Ile Leu Leu Phe Tyr Val 
1               5                   10                  15      


Ser Arg Ala Ser Cys Gln Asp Thr Phe Thr Ala Ala Val Tyr Glu His 
            20                  25                  30          


Ala Ala Ile Leu Pro Asn Ala Thr Leu Thr Pro Val Ser Arg Glu Glu 
        35                  40                  45              


Ala Leu Ala Leu Met Asn Arg Asn Leu Asp Ile Leu Glu Gly Ala Ile 
    50                  55                  60                  


Thr Ser Ala Ala Asp Gln Gly Ala His Ile Ile Val Thr Pro Glu Asp 
65                  70                  75                  80  


Ala Ile Tyr Gly Trp Asn Phe Asn Arg Asp Ser Leu Tyr Pro Tyr Leu 
                85                  90                  95      


Glu Asp Ile Pro Asp Pro Glu Val Asn Trp Ile Pro Cys Asn Asn Arg 
            100                 105                 110         


Asn Arg Phe Gly Gln Thr Pro Val Gln Glu Arg Leu Ser Cys Leu Ala 
        115                 120                 125             


Lys Asn Asn Ser Ile Tyr Val Val Ala Asn Ile Gly Asp Lys Lys Pro 
    130                 135                 140                 


Cys Asp Thr Ser Asp Pro Gln Cys Pro Pro Asp Gly Arg Tyr Gln Tyr 
145                 150                 155                 160 


Asn Thr Asp Val Val Phe Asp Ser Gln Gly Lys Leu Val Ala Arg Tyr 
                165                 170                 175     


His Lys Gln Asn Leu Phe Met Gly Glu Asn Gln Phe Asn Val Pro Lys 
            180                 185                 190         


Glu Pro Glu Ile Val Thr Phe Asn Thr Thr Phe Gly Ser Phe Gly Ile 
        195                 200                 205             


Phe Thr Cys Phe Asp Ile Leu Phe His Asp Pro Ala Val Thr Leu Val 
    210                 215                 220                 


Lys Asp Phe His Val Asp Thr Ile Val Phe Pro Thr Ala Trp Met Asn 
225                 230                 235                 240 


Val Leu Pro His Leu Ser Ala Val Glu Phe His Ser Ala Trp Ala Met 
                245                 250                 255     


Gly Met Arg Val Asn Phe Leu Ala Ser Asn Ile His Tyr Pro Ser Lys 
            260                 265                 270         


Lys Met Thr Gly Ser Gly Ile Tyr Ala Pro Asn Ser Ser Arg Ala Phe 
        275                 280                 285             


His Tyr Asp Met Lys Thr Glu Glu Gly Lys Leu Leu Leu Ser Gln Leu 
    290                 295                 300                 


Asp Ser His Pro Ser His Ser Ala Val Val Asn Trp Thr Ser Tyr Ala 
305                 310                 315                 320 


Ser Ser Ile Glu Ala Leu Ser Ser Gly Asn Lys Glu Phe Lys Gly Thr 
                325                 330                 335     


Val Phe Phe Asp Glu Phe Thr Phe Val Lys Leu Thr Gly Val Ala Gly 
            340                 345                 350         


Asn Tyr Thr Val Cys Gln Lys Asp Leu Cys Cys His Leu Ser Tyr Lys 
        355                 360                 365             


Met Ser Glu Asn Ile Pro Asn Glu Val Tyr Ala Leu Gly Ala Phe Asp 
    370                 375                 380                 


Gly Leu His Thr Val Glu Gly Arg Tyr Tyr Leu Gln Ile Cys Thr Leu 
385                 390                 395                 400 


Leu Lys Cys Lys Thr Thr Asn Leu Asn Thr Cys Gly Asp Ser Ala Glu 
                405                 410                 415     


Thr Ala Ser Thr Arg Phe Glu Met Phe Ser Leu Ser Gly Thr Phe Gly 
            420                 425                 430         


Thr Gln Tyr Val Phe Pro Glu Val Leu Leu Ser Glu Asn Gln Leu Ala 
        435                 440                 445             


Pro Gly Glu Phe Gln Val Ser Thr Asp Gly Arg Leu Phe Ser Leu Lys 
    450                 455                 460                 


Pro Thr Ser Gly Pro Val Leu Thr Val Thr Leu Phe Gly Arg Leu Tyr 
465                 470                 475                 480 


Glu Lys Asp Trp Ala Ser Asn Ala Ser Ser Gly Leu Thr Ala Gln Ala 
                485                 490                 495     


Arg Ile Ile Met Leu Ile Val Ile Ala Pro Ile Val Cys Ser Leu Ser 
            500                 505                 510         


Trp 
    


<210>  2
<211>  3844
<212>  DNA
<213>  Homo sapiens

<400>  2
agcactcatt ggacttcagc atgactactc agttgccagc ttacgtggca attttgcttt     60

tctatgtctc aagagccagc tgccaggaca ctttcactgc agctgtttat gagcatgcag    120

cgatattgcc caatgccacc ctaacaccag tgtctcgtga ggaggctttg gcattaatga    180

atcggaatct ggacattttg gaaggagcga tcacatcagc agcagatcag ggtgcgcata    240

ttattgtgac tccagaagat gctatttatg gctggaactt caacagggac tctctctacc    300

catatttgga ggacatccca gaccctgaag taaactggat cccctgtaat aatcgtaaca    360

gatttggcca gaccccagta caagaaagac tcagctgcct ggccaagaac aactctatct    420

atgttgtggc aaatattggg gacaagaagc catgcgatac cagtgatcct cagtgtcccc    480

ctgatggccg ttaccaatac aacactgatg tggtatttga ttctcaagga aaactggtgg    540

cacgctacca taagcaaaac cttttcatgg gtgaaaatca attcaatgta cccaaggagc    600

ctgagattgt gactttcaat accacctttg gaagttttgg cattttcaca tgctttgata    660

tactcttcca tgatcctgct gttaccttgg tgaaagattt ccacgtggac accatagtat    720

tcccaacagc ttggatgaat gttttgccac atttgtcagc tgttgaattc cactcagctt    780

gggctatggg catgagggtc aatttccttg catccaacat acattacccc tcaaagaaaa    840

tgacaggaag tggcatctat gcacccaatt cttcaagagc atttcattat gatatgaaga    900

cagaagaggg aaaactcctc ctctcgcaac tggattccca cccatcccat tctgcagtgg    960

tgaactggac ttcctatgcc agcagtatag aagcgctctc atcaggaaac aaggaattta   1020

aaggcactgt ctttttcgat gaattcactt ttgtgaagct cacaggagtt gcaggaaatt   1080

atacagtttg tcagaaagat ctctgctgtc atttaagcta caaaatgtct gagaacatac   1140

caaatgaagt gtacgctcta ggggcatttg acggactgca cactgtggaa gggcgctatt   1200

atctacagat ttgtaccctg ttgaaatgta aaacgactaa tttaaacact tgcggtgact   1260

cagctgaaac agcttctacc aggtttgaaa tgttctccct cagtggcact ttcggaaccc   1320

agtatgtctt tcctgaggtg ttgctgagtg aaaatcagct tgcacctgga gaatttcagg   1380

tgtcaactga cggacgcttg tttagtctga agccaacatc cggacctgtc ttaacagtaa   1440

ctctgtttgg gaggttgtat gagaaggact gggcatcaaa tgcttcatca ggcctcacag   1500

cacaagcaag aataataatg ctaatagtta tagcacctat tgtatgctca ttaagttggt   1560

agaatattga ctttttctct tttttatttg ggataattta aaaaatgatg gatgagaaaa   1620

gaaagattgg tccgggttaa tattatcctc tagtataagt gaattactag tttctcttta   1680

tttagacaaa cacacacaca ccagataata taaacttaat aaattatctg ttaatgtaga   1740

ttttatttaa aaaactatat ttgaacattg gtctttcttg gacgtgagct aattatatca   1800

aataagtatc acaaatcttt tacgcagaag aaataaaaac tacgggtaga aaacataaga   1860

actatcataa aatttactta caaggaggct gctcttgtta ccacttttat tatattacgt   1920

atcacttatt cagctctgct gaaaatttcc aatgactttg tttgtttgct ctttttgttt   1980

tttacctaaa caatacattt tgattctctt gtgggttgat aatgtctccc caaaatttac   2040

atgttgaagc acctcagaat gtgactgtat ttggagacag ggtctttaaa gaggtaaaat   2100

aaggtcatta ggatagaccc taattcaata tgactgatga tcataaaaga agaggcgagt   2160

agggcacaac aggcacaaag ggagaccata aggagacaca gaggaaggac aactctttac   2220

aagctaagaa gagagggcct cagaagaaac caaccctgcc aacaccttga tcttggactt   2280

ccagcctcca aaactatgag aaataaattt ctattgttta agtcacccag tccatggtac   2340

tttgttaggc agccctggca aatgaatcaa agacccattc ctgttcctct ccccaccact   2400

actgttttct actgtaatct gaagcttcaa caaaaggctt acctggtaag aatattcagc   2460

tggtctgggt cctcaagact ccaatagaca ctcttagaga aggattgctg atggattgat   2520

agtgaaacca ttagatcatt gaattcctct ggaattagaa aaccagagag tcccatttta   2580

agaaattaga tatttaatat agcattgtgt gttctatttt agtaacagca gaatctcttg   2640

acattacaca actcagtgaa acaacatcat ttaagccaaa atatctccca actgactgat   2700

agactctgag cactaatatc atagtgctgt gatgatggac aattacatag taccgataac   2760

agccatgcac tgtgcaaagc atgcccttct gcacaggaga gcaaggcact tgcagtagtg   2820

atctatgcca gcaaaacatc attttgagac aaacattttt gtggcagatg tttttcctaa   2880

aaagtactat atcatccaag aaatatttga gtaaaatccc ttgttctttt gggtgacatt   2940

aactgacatt tgcttttttt caagacctaa tagaaaataa gaaagcccat aatgtattta   3000

gaaacaggaa tcctcagagc aattctctgt attctcatat aatttcaatg taaaacagaa   3060

aacatattga tgtgttggtg ataggcttga attattaaaa acttcaaaaa catcctaagt   3120

gtttcttttt tgctcaacgt tgtcaactat agtaggtctc ccttgtggtg taatgaattg   3180

cccccaaact attatcttaa aacaacaaac atttattatc ttatagcatt tctgagggtc   3240

aggatctggg actggcttag tggagttgtt ctggatcagg gcctttggaa agttgtagtt   3300

aacttgtccc cagggctgcc atcatctcaa ggctcgggtg gggctggaga aaatctgctt   3360

ctcagctcac tcacggcggt tgccaggcct ccattcttta ggatgctaga aaaactttca   3420

taaaatgtca tctggcttct cctagagcaa tgatactgag agagaaagca catgagagaa   3480

agagcgaggg aacttggatg taagccacag tctttgaaaa cctaatcaca gaagtgacat   3540

ctcttcttcc acatgatgtt ggtcacatgg accaacaatg gcacaacgtg gacagaatca   3600

aacagagttg agaatatcag gaggtggggc ttcatggggg ccattttgga tgctatcata   3660

gtgaatatat gtatttatat ttatatctgt atatattgca atgtaattta aaaaatagga   3720

ttgttttcct tttctttttg ctatatgtga tatgtatttc aaaatacact cccaatagtt   3780

acgtctgaaa agcactacac taaaaaactt tctatacatt gaataattaa attaaataat   3840

ctaa                                                                3844


