                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
 
<120>  DNA POLYMERASE THETA MUTANTS, METHODS OF PRODUCING THESE MUTANTS,
        AND THEIR USES

<130>  BCT180285 QT

<150>  US 62/560,693
<151>  2017-09-20

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  2590
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Leu Leu Arg Arg Ser Gly Lys Arg Arg Arg Ser Glu Ser Gly 
1               5                   10                  15      


Ser Asp Ser Phe Ser Gly Ser Gly Gly Asp Ser Ser Ala Ser Pro Gln 
            20                  25                  30          


Phe Leu Ser Gly Ser Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Cys 
        35                  40                  45              


Leu Lys Ala Ala Ala Ala Gly Glu Cys Lys Pro Thr Val Pro Asp Tyr 
    50                  55                  60                  


Glu Arg Asp Lys Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala Val 
65                  70                  75                  80  


Leu Glu Lys Tyr His Ser Phe Gly Val Lys Lys Met Phe Glu Trp Gln 
                85                  90                  95      


Ala Glu Cys Leu Leu Leu Gly Gln Val Leu Glu Gly Lys Asn Leu Val 
            100                 105                 110         


Tyr Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu Leu 
        115                 120                 125             


Ile Leu Lys Arg Val Leu Glu Met Arg Lys Lys Ala Leu Phe Ile Leu 
    130                 135                 140                 


Pro Phe Val Ser Val Ala Lys Glu Lys Lys Tyr Tyr Leu Gln Ser Leu 
145                 150                 155                 160 


Phe Gln Glu Val Gly Ile Lys Val Asp Gly Tyr Met Gly Ser Thr Ser 
                165                 170                 175     


Pro Ser Arg His Phe Ser Ser Leu Asp Ile Ala Val Cys Thr Ile Glu 
            180                 185                 190         


Arg Ala Asn Gly Leu Ile Asn Arg Leu Ile Glu Glu Asn Lys Met Asp 
        195                 200                 205             


Leu Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp Ser 
    210                 215                 220                 


His Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Cys Tyr Ile 
225                 230                 235                 240 


Thr Arg Lys Ser Ala Ser Cys Gln Ala Asp Leu Ala Ser Ser Leu Ser 
                245                 250                 255     


Asn Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu Glu 
            260                 265                 270         


Leu Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe Arg 
        275                 280                 285             


Pro Val Pro Leu Leu Glu Ser Val Lys Val Gly Asn Ser Ile Tyr Asp 
    290                 295                 300                 


Ser Ser Met Lys Leu Val Arg Glu Phe Glu Pro Met Leu Gln Val Lys 
305                 310                 315                 320 


Gly Asp Glu Asp His Val Val Ser Leu Cys Tyr Glu Thr Ile Cys Asp 
                325                 330                 335     


Asn His Ser Val Leu Leu Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys 
            340                 345                 350         


Leu Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln Ala 
        355                 360                 365             


Glu Gly Leu Val Lys Pro Ser Glu Cys Pro Pro Val Ile Leu Glu Gln 
    370                 375                 380                 


Lys Glu Leu Leu Glu Val Met Asp Gln Leu Arg Arg Leu Pro Ser Gly 
385                 390                 395                 400 


Leu Asp Ser Val Leu Gln Lys Thr Val Pro Trp Gly Val Ala Phe His 
                405                 410                 415     


His Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe 
            420                 425                 430         


Arg Gln Gly Leu Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser 
        435                 440                 445             


Gly Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Ile Phe 
    450                 455                 460                 


Gly Gly Arg Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg 
465                 470                 475                 480 


Ala Gly Arg Lys Gly Val Asp Thr Val Gly Glu Ser Ile Leu Ile Cys 
                485                 490                 495     


Lys Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu 
            500                 505                 510         


Lys Pro Val Arg Ser Cys Leu Gln Arg Arg Glu Gly Glu Glu Val Thr 
        515                 520                 525             


Gly Ser Met Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala 
    530                 535                 540                 


Ser Thr Ser Gln Asp Met His Thr Tyr Ala Ala Cys Thr Phe Leu Ala 
545                 550                 555                 560 


Ala Ser Met Lys Glu Gly Lys Gln Gly Ile Gln Arg Asn Gln Glu Ser 
                565                 570                 575     


Val Gln Leu Gly Ala Ile Glu Ala Cys Val Met Trp Leu Leu Glu Asn 
            580                 585                 590         


Glu Phe Ile Gln Ser Thr Glu Ala Ser Asp Gly Thr Glu Gly Lys Val 
        595                 600                 605             


Tyr His Pro Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser 
    610                 615                 620                 


Pro Ala Asp Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys 
625                 630                 635                 640 


Gly Phe Val Leu Glu Asn Asp Leu His Ile Leu Tyr Leu Val Thr Pro 
                645                 650                 655     


Met Phe Glu Asp Trp Thr Thr Ile Asp Trp Tyr Arg Phe Phe Cys Leu 
            660                 665                 670         


Trp Glu Lys Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly 
        675                 680                 685             


Val Glu Glu Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala 
    690                 695                 700                 


Arg Thr Glu Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe 
705                 710                 715                 720 


Thr Ser Leu Val Leu Leu Asp Leu Ile Ser Glu Val Pro Leu Arg Glu 
                725                 730                 735     


Ile Asn Gln Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln 
            740                 745                 750         


Gln Ser Ala Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg 
        755                 760                 765             


Leu Gly Trp His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg 
    770                 775                 780                 


Leu Thr Phe Gly Ile Gln Arg Glu Leu Cys Asp Leu Val Arg Val Ser 
785                 790                 795                 800 


Leu Leu Asn Ala Gln Arg Ala Arg Val Leu Tyr Ala Ser Gly Phe His 
                805                 810                 815     


Thr Val Ala Asp Leu Ala Arg Ala Asn Ile Val Glu Val Glu Val Ile 
            820                 825                 830         


Leu Lys Asn Ala Val Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu 
        835                 840                 845             


Glu Glu Glu Ala Val Glu Glu Arg Arg Asn Met Arg Thr Ile Trp Val 
    850                 855                 860                 


Thr Gly Arg Lys Gly Leu Thr Glu Arg Glu Ala Ala Ala Leu Ile Val 
865                 870                 875                 880 


Glu Glu Ala Arg Met Ile Leu Gln Gln Asp Leu Val Glu Met Gly Val 
                885                 890                 895     


Gln Trp Asn Pro Cys Ala Leu Leu His Ser Ser Thr Cys Ser Leu Thr 
            900                 905                 910         


His Ser Glu Ser Glu Val Lys Glu His Thr Phe Ile Ser Gln Thr Lys 
        915                 920                 925             


Ser Ser Tyr Lys Lys Leu Thr Ser Lys Asn Lys Ser Asn Thr Ile Phe 
    930                 935                 940                 


Ser Asp Ser Tyr Ile Lys His Ser Pro Asn Ile Val Gln Asp Leu Asn 
945                 950                 955                 960 


Lys Ser Arg Glu His Thr Ser Ser Phe Asn Cys Asn Phe Gln Asn Gly 
                965                 970                 975     


Asn Gln Glu His Gln Thr Cys Ser Ile Phe Arg Ala Arg Lys Arg Ala 
            980                 985                 990         


Ser Leu Asp Ile Asn Lys Glu Lys  Pro Gly Ala Ser Gln  Asn Glu Gly 
        995                 1000                 1005             


Lys Thr  Ser Asp Lys Lys Val  Val Gln Thr Phe Ser  Gln Lys Thr 
    1010                 1015                 1020             


Lys Lys  Ala Pro Leu Asn Phe  Asn Ser Glu Lys Met  Ser Arg Ser 
    1025                 1030                 1035             


Phe Arg  Ser Trp Lys Arg Arg  Lys His Leu Lys Arg  Ser Arg Asp 
    1040                 1045                 1050             


Ser Ser  Pro Leu Lys Asp Ser  Gly Ala Cys Arg Ile  His Leu Gln 
    1055                 1060                 1065             


Gly Gln  Thr Leu Ser Asn Pro  Ser Leu Cys Glu Asp  Pro Phe Thr 
    1070                 1075                 1080             


Leu Asp  Glu Lys Lys Thr Glu  Phe Arg Asn Ser Gly  Pro Phe Ala 
    1085                 1090                 1095             


Lys Asn  Val Ser Leu Ser Gly  Lys Glu Lys Asp Asn  Lys Thr Ser 
    1100                 1105                 1110             


Phe Pro  Leu Gln Ile Lys Gln  Asn Cys Ser Trp Asn  Ile Thr Leu 
    1115                 1120                 1125             


Thr Asn  Asp Asn Phe Val Glu  His Ile Val Thr Gly  Ser Gln Ser 
    1130                 1135                 1140             


Lys Asn  Val Thr Cys Gln Ala  Thr Ser Val Val Ser  Glu Lys Gly 
    1145                 1150                 1155             


Arg Gly  Val Ala Val Glu Ala  Glu Lys Ile Asn Glu  Val Leu Ile 
    1160                 1165                 1170             


Gln Asn  Gly Ser Lys Asn Gln  Asn Val Tyr Met Lys  His His Asp 
    1175                 1180                 1185             


Ile His  Pro Ile Asn Gln Tyr  Leu Arg Lys Gln Ser  His Glu Gln 
    1190                 1195                 1200             


Thr Ser  Thr Ile Thr Lys Gln  Lys Asn Ile Ile Glu  Arg Gln Met 
    1205                 1210                 1215             


Pro Cys  Glu Ala Val Ser Ser  Tyr Ile Asn Arg Asp  Ser Asn Val 
    1220                 1225                 1230             


Thr Ile  Asn Cys Glu Arg Ile  Lys Leu Asn Thr Glu  Glu Asn Lys 
    1235                 1240                 1245             


Pro Ser  His Phe Gln Ala Leu  Gly Asp Asp Ile Ser  Arg Thr Val 
    1250                 1255                 1260             


Ile Pro  Ser Glu Val Leu Pro  Ser Ala Gly Ala Phe  Ser Lys Ser 
    1265                 1270                 1275             


Glu Gly  Gln His Glu Asn Phe  Leu Asn Ile Ser Arg  Leu Gln Glu 
    1280                 1285                 1290             


Lys Thr  Gly Thr Tyr Thr Thr  Asn Lys Thr Lys Asn  Asn His Val 
    1295                 1300                 1305             


Ser Asp  Leu Gly Leu Val Leu  Cys Asp Phe Glu Asp  Ser Phe Tyr 
    1310                 1315                 1320             


Leu Asp  Thr Gln Ser Glu Lys  Ile Ile Gln Gln Met  Ala Thr Glu 
    1325                 1330                 1335             


Asn Ala  Lys Leu Gly Ala Lys  Asp Thr Asn Leu Ala  Ala Gly Ile 
    1340                 1345                 1350             


Met Gln  Lys Ser Leu Val Gln  Gln Asn Ser Met Asn  Ser Phe Gln 
    1355                 1360                 1365             


Lys Glu  Cys His Ile Pro Phe  Pro Ala Glu Gln His  Pro Leu Gly 
    1370                 1375                 1380             


Ala Thr  Lys Ile Asp His Leu  Asp Leu Lys Thr Val  Gly Thr Met 
    1385                 1390                 1395             


Lys Gln  Ser Ser Asp Ser His  Gly Val Asp Ile Leu  Thr Pro Glu 
    1400                 1405                 1410             


Ser Pro  Ile Phe His Ser Pro  Ile Leu Leu Glu Glu  Asn Gly Leu 
    1415                 1420                 1425             


Phe Leu  Lys Lys Asn Glu Val  Ser Val Thr Asp Ser  Gln Leu Asn 
    1430                 1435                 1440             


Ser Phe  Leu Gln Gly Tyr Gln  Thr Gln Glu Thr Val  Lys Pro Val 
    1445                 1450                 1455             


Ile Leu  Leu Ile Pro Gln Lys  Arg Thr Pro Thr Gly  Val Glu Gly 
    1460                 1465                 1470             


Glu Cys  Leu Pro Val Pro Glu  Thr Ser Leu Asn Met  Ser Asp Ser 
    1475                 1480                 1485             


Leu Leu  Phe Asp Ser Phe Ser  Asp Asp Tyr Leu Val  Lys Glu Gln 
    1490                 1495                 1500             


Leu Pro  Asp Met Gln Met Lys  Glu Pro Leu Pro Ser  Glu Val Thr 
    1505                 1510                 1515             


Ser Asn  His Phe Ser Asp Ser  Leu Cys Leu Gln Glu  Asp Leu Ile 
    1520                 1525                 1530             


Lys Lys  Ser Asn Val Asn Glu  Asn Gln Asp Thr His  Gln Gln Leu 
    1535                 1540                 1545             


Thr Cys  Ser Asn Asp Glu Ser  Ile Ile Phe Ser Glu  Met Asp Ser 
    1550                 1555                 1560             


Val Gln  Met Val Glu Ala Leu  Asp Asn Val Asp Ile  Phe Pro Val 
    1565                 1570                 1575             


Gln Glu  Lys Asn His Thr Val  Val Ser Pro Arg Ala  Leu Glu Leu 
    1580                 1585                 1590             


Ser Asp  Pro Val Leu Asp Glu  His His Gln Gly Asp  Gln Asp Gly 
    1595                 1600                 1605             


Gly Asp  Gln Asp Glu Arg Ala  Glu Lys Ser Lys Leu  Thr Gly Thr 
    1610                 1615                 1620             


Arg Gln  Asn His Ser Phe Ile  Trp Ser Gly Ala Ser  Phe Asp Leu 
    1625                 1630                 1635             


Ser Pro  Gly Leu Gln Arg Ile  Leu Asp Lys Val Ser  Ser Pro Leu 
    1640                 1645                 1650             


Glu Asn  Glu Lys Leu Lys Ser  Met Thr Ile Asn Phe  Ser Ser Leu 
    1655                 1660                 1665             


Asn Arg  Lys Asn Thr Glu Leu  Asn Glu Glu Gln Glu  Val Ile Ser 
    1670                 1675                 1680             


Asn Leu  Glu Thr Lys Gln Val  Gln Gly Ile Ser Phe  Ser Ser Asn 
    1685                 1690                 1695             


Asn Glu  Val Lys Ser Lys Ile  Glu Met Leu Glu Asn  Asn Ala Asn 
    1700                 1705                 1710             


His Asp  Glu Thr Ser Ser Leu  Leu Pro Arg Lys Glu  Ser Asn Ile 
    1715                 1720                 1725             


Val Asp  Asp Asn Gly Leu Ile  Pro Pro Thr Pro Ile  Pro Thr Ser 
    1730                 1735                 1740             


Ala Ser  Lys Leu Thr Phe Pro  Gly Ile Leu Glu Thr  Pro Val Asn 
    1745                 1750                 1755             


Pro Trp  Lys Thr Asn Asn Val  Leu Gln Pro Gly Glu  Ser Tyr Leu 
    1760                 1765                 1770             


Phe Gly  Ser Pro Ser Asp Ile  Lys Asn His Asp Leu  Ser Pro Gly 
    1775                 1780                 1785             


Ser Arg  Asn Gly Phe Lys Asp  Asn Ser Pro Ile Ser  Asp Thr Ser 
    1790                 1795                 1800             


Phe Ser  Leu Gln Leu Ser Gln  Asp Gly Leu Gln Leu  Thr Pro Ala 
    1805                 1810                 1815             


Ser Ser  Ser Ser Glu Ser Leu  Ser Ile Ile Asp Val  Ala Ser Asp 
    1820                 1825                 1830             


Gln Asn  Leu Phe Gln Thr Phe  Ile Lys Glu Trp Arg  Cys Lys Lys 
    1835                 1840                 1845             


Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys Ile Arg  Ser Leu Thr 
    1850                 1855                 1860             


Ser Ser  Lys Thr Ala Thr Ile  Gly Ser Arg Phe Lys  Gln Ala Ser 
    1865                 1870                 1875             


Ser Pro  Gln Glu Ile Pro Ile  Arg Asp Asp Gly Phe  Pro Ile Lys 
    1880                 1885                 1890             


Gly Cys  Asp Asp Thr Leu Val  Val Gly Leu Ala Val  Cys Trp Gly 
    1895                 1900                 1905             


Gly Arg  Asp Ala Tyr Tyr Phe  Ser Leu Gln Lys Glu  Gln Lys His 
    1910                 1915                 1920             


Ser Glu  Ile Ser Ala Ser Leu  Val Pro Pro Ser Leu  Asp Pro Ser 
    1925                 1930                 1935             


Leu Thr  Leu Lys Asp Arg Met  Trp Tyr Leu Gln Ser  Cys Leu Arg 
    1940                 1945                 1950             


Lys Glu  Ser Asp Lys Glu Cys  Ser Val Val Ile Tyr  Asp Phe Ile 
    1955                 1960                 1965             


Gln Ser  Tyr Lys Ile Leu Leu  Leu Ser Cys Gly Ile  Ser Leu Glu 
    1970                 1975                 1980             


Gln Ser  Tyr Glu Asp Pro Lys  Val Ala Cys Trp Leu  Leu Asp Pro 
    1985                 1990                 1995             


Asp Ser  Gln Glu Pro Thr Leu  His Ser Ile Val Thr  Ser Phe Leu 
    2000                 2005                 2010             


Pro His  Glu Leu Pro Leu Leu  Glu Gly Met Glu Thr  Ser Gln Gly 
    2015                 2020                 2025             


Ile Gln  Ser Leu Gly Leu Asn  Ala Gly Ser Glu His  Ser Gly Arg 
    2030                 2035                 2040             


Tyr Arg  Ala Ser Val Glu Ser  Ile Leu Ile Phe Asn  Ser Met Asn 
    2045                 2050                 2055             


Gln Leu  Asn Ser Leu Leu Gln  Lys Glu Asn Leu Gln  Asp Val Phe 
    2060                 2065                 2070             


Arg Lys  Val Glu Met Pro Ser  Gln Tyr Cys Leu Ala  Leu Leu Glu 
    2075                 2080                 2085             


Leu Asn  Gly Ile Gly Phe Ser  Thr Ala Glu Cys Glu  Ser Gln Lys 
    2090                 2095                 2100             


His Ile  Met Gln Ala Lys Leu  Asp Ala Ile Glu Thr  Gln Ala Tyr 
    2105                 2110                 2115             


Gln Leu  Ala Gly His Ser Phe  Ser Phe Thr Ser Ser  Asp Asp Ile 
    2120                 2125                 2130             


Ala Glu  Val Leu Phe Leu Glu  Leu Lys Leu Pro Pro  Asn Arg Glu 
    2135                 2140                 2145             


Met Lys  Asn Gln Gly Ser Lys  Lys Thr Leu Gly Ser  Thr Arg Arg 
    2150                 2155                 2160             


Gly Ile  Asp Asn Gly Arg Lys  Leu Arg Leu Gly Arg  Gln Phe Ser 
    2165                 2170                 2175             


Thr Ser  Lys Asp Val Leu Asn  Lys Leu Lys Ala Leu  His Pro Leu 
    2180                 2185                 2190             


Pro Gly  Leu Ile Leu Glu Trp  Arg Arg Ile Thr Asn  Ala Ile Thr 
    2195                 2200                 2205             


Lys Val  Val Phe Pro Leu Gln  Arg Glu Lys Cys Leu  Asn Pro Phe 
    2210                 2215                 2220             


Leu Gly  Met Glu Arg Ile Tyr  Pro Val Ser Gln Ser  His Thr Ala 
    2225                 2230                 2235             


Thr Gly  Arg Ile Thr Phe Thr  Glu Pro Asn Ile Gln  Asn Val Pro 
    2240                 2245                 2250             


Arg Asp  Phe Glu Ile Lys Met  Pro Thr Leu Val Gly  Glu Ser Pro 
    2255                 2260                 2265             


Pro Ser  Gln Ala Val Gly Lys  Gly Leu Leu Pro Met  Gly Arg Gly 
    2270                 2275                 2280             


Lys Tyr  Lys Lys Gly Phe Ser  Val Asn Pro Arg Cys  Gln Ala Gln 
    2285                 2290                 2295             


Met Glu  Glu Arg Ala Ala Asp  Arg Gly Met Pro Phe  Ser Ile Ser 
    2300                 2305                 2310             


Met Arg  His Ala Phe Val Pro  Phe Pro Gly Gly Ser  Ile Leu Ala 
    2315                 2320                 2325             


Ala Asp  Tyr Ser Gln Leu Glu  Leu Arg Ile Leu Ala  His Leu Ser 
    2330                 2335                 2340             


His Asp  Arg Arg Leu Ile Gln  Val Leu Asn Thr Gly  Ala Asp Val 
    2345                 2350                 2355             


Phe Arg  Ser Ile Ala Ala Glu  Trp Lys Met Ile Glu  Pro Glu Ser 
    2360                 2365                 2370             


Val Gly  Asp Asp Leu Arg Gln  Gln Ala Lys Gln Ile  Cys Tyr Gly 
    2375                 2380                 2385             


Ile Ile  Tyr Gly Met Gly Ala  Lys Ser Leu Gly Glu  Gln Met Gly 
    2390                 2395                 2400             


Ile Lys  Glu Asn Asp Ala Ala  Cys Tyr Ile Asp Ser  Phe Lys Ser 
    2405                 2410                 2415             


Arg Tyr  Thr Gly Ile Asn Gln  Phe Met Thr Glu Thr  Val Lys Asn 
    2420                 2425                 2430             


Cys Lys  Arg Asp Gly Phe Val  Gln Thr Ile Leu Gly  Arg Arg Arg 
    2435                 2440                 2445             


Tyr Leu  Pro Gly Ile Lys Asp  Asn Asn Pro Tyr Arg  Lys Ala His 
    2450                 2455                 2460             


Ala Glu  Arg Gln Ala Ile Asn  Thr Ile Val Gln Gly  Ser Ala Ala 
    2465                 2470                 2475             


Asp Ile  Val Lys Ile Ala Thr  Val Asn Ile Gln Lys  Gln Leu Glu 
    2480                 2485                 2490             


Thr Phe  His Ser Thr Phe Lys  Ser His Gly His Arg  Glu Gly Met 
    2495                 2500                 2505             


Leu Gln  Ser Asp Gln Thr Gly  Leu Ser Arg Lys Arg  Lys Leu Gln 
    2510                 2515                 2520             


Gly Met  Phe Cys Pro Ile Arg  Gly Gly Phe Phe Ile  Leu Gln Leu 
    2525                 2530                 2535             


His Asp  Glu Leu Leu Tyr Glu  Val Ala Glu Glu Asp  Val Val Gln 
    2540                 2545                 2550             


Val Ala  Gln Ile Val Lys Asn  Glu Met Glu Ser Ala  Val Lys Leu 
    2555                 2560                 2565             


Ser Val  Lys Leu Lys Val Lys  Val Lys Ile Gly Ala  Ser Trp Gly 
    2570                 2575                 2580             


Glu Leu  Lys Asp Phe Asp Val  
    2585                 2590 


<210>  2
<211>  2544
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ser Leu Pro Arg Arg Ser Arg Lys Arg Arg Arg Ser Ser Ser Gly 
1               5                   10                  15      


Ser Asp Thr Phe Ser Gly Asp Gly Asp Ser Phe Val Ser Pro Gln Leu 
            20                  25                  30          


Arg Cys Gly Pro Val Leu Ser Pro Pro Pro Gly Leu Gly Arg Gly Arg 
        35                  40                  45              


Arg Leu Thr Gly Thr Gly Thr Asn Lys Arg Arg Val Ser Asp Asp Gln 
    50                  55                  60                  


Ile Asp Gln Leu Leu Leu Ala Asn Trp Gly Leu Pro Lys Ala Val Leu 
65                  70                  75                  80  


Glu Lys Tyr His Ser Phe Gly Val Arg Lys Met Phe Glu Trp Gln Ala 
                85                  90                  95      


Glu Cys Leu Leu Leu Gly His Val Leu Glu Gly Lys Asn Leu Val Tyr 
            100                 105                 110         


Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ala Glu Leu Leu Ile 
        115                 120                 125             


Leu Lys Arg Val Leu Glu Thr Arg Lys Lys Ala Leu Phe Ile Leu Pro 
    130                 135                 140                 


Phe Val Ser Val Ala Lys Glu Lys Lys Cys Tyr Leu Gln Ser Leu Phe 
145                 150                 155                 160 


Gln Glu Val Gly Leu Lys Val Asp Gly Tyr Met Gly Ser Thr Ser Pro 
                165                 170                 175     


Thr Gly Gln Phe Ser Ser Leu Asp Ile Ala Val Cys Thr Ile Glu Arg 
            180                 185                 190         


Ala Asn Gly Leu Val Asn Arg Leu Ile Glu Glu Asn Lys Met Asp Leu 
        195                 200                 205             


Leu Gly Met Val Val Val Asp Glu Leu His Met Leu Gly Asp Ser His 
    210                 215                 220                 


Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Cys Tyr Val Thr 
225                 230                 235                 240 


Arg Lys Ser Ala Ser His Gln Ala Glu Ser Ala Ser Thr Leu Ser Asn 
                245                 250                 255     


Ala Val Gln Ile Val Gly Met Ser Ala Thr Leu Pro Asn Leu Gln Leu 
            260                 265                 270         


Val Ala Ser Trp Leu Asn Ala Glu Leu Tyr His Thr Asp Phe Arg Pro 
        275                 280                 285             


Val Pro Leu Leu Glu Ser Ile Lys Ile Gly Asn Ser Ile Tyr Asp Ser 
    290                 295                 300                 


Ser Met Lys Leu Val Arg Glu Phe Gln Pro Leu Leu Gln Val Lys Gly 
305                 310                 315                 320 


Asp Glu Asp His Ile Val Ser Leu Cys Tyr Glu Thr Ile Gln Asp Asn 
                325                 330                 335     


His Ser Val Leu Ile Phe Cys Pro Ser Lys Lys Trp Cys Glu Lys Val 
            340                 345                 350         


Ala Asp Ile Ile Ala Arg Glu Phe Tyr Asn Leu His His Gln Pro Glu 
        355                 360                 365             


Gly Leu Val Lys Ser Ser Glu Phe Pro Pro Val Ile Leu Asp Gln Lys 
    370                 375                 380                 


Ser Leu Leu Glu Val Met Asp Gln Leu Lys Arg Ser Pro Ser Gly Leu 
385                 390                 395                 400 


Asp Ser Val Leu Lys Asn Thr Val Pro Trp Gly Val Ala Phe His His 
                405                 410                 415     


Ala Gly Leu Thr Phe Glu Glu Arg Asp Ile Ile Glu Gly Ala Phe Arg 
            420                 425                 430         


Gln Gly Phe Ile Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser Gly 
        435                 440                 445             


Val Asn Leu Pro Ala Arg Arg Val Ile Ile Arg Thr Pro Ile Phe Ser 
    450                 455                 460                 


Gly Gln Pro Leu Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg Ala 
465                 470                 475                 480 


Gly Arg Lys Gly Val Asp Thr Met Gly Glu Ser Ile Leu Val Cys Lys 
                485                 490                 495     


Asn Ser Glu Lys Ser Lys Gly Ile Ala Leu Leu Gln Gly Ser Leu Glu 
            500                 505                 510         


Pro Val His Ser Cys Leu Gln Arg Gln Gly Glu Val Thr Ala Ser Met 
        515                 520                 525             


Ile Arg Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala Ser Thr Ser 
    530                 535                 540                 


Gln Asp Met Gln Thr Tyr Ala Ala Cys Thr Phe Leu Ala Ala Ala Ile 
545                 550                 555                 560 


Gln Glu Gly Lys Gln Gly Met Gln Arg Asn Gln Asp Asp Ala Gln Leu 
                565                 570                 575     


Gly Ala Ile Asp Ala Cys Val Thr Trp Leu Leu Glu Asn Glu Phe Ile 
            580                 585                 590         


Gln Val Ala Glu Pro Gly Asp Gly Thr Gly Gly Lys Val Tyr His Pro 
        595                 600                 605             


Thr His Leu Gly Ser Ala Thr Leu Ser Ser Ser Leu Ser Pro Thr Asp 
    610                 615                 620                 


Thr Leu Asp Ile Phe Ala Asp Leu Gln Arg Ala Met Lys Gly Phe Val 
625                 630                 635                 640 


Leu Glu Asn Asp Leu His Ile Val Tyr Leu Val Thr Pro Val Phe Glu 
                645                 650                 655     


Asp Trp Ile Ser Ile Asp Trp Tyr Arg Phe Phe Cys Leu Trp Glu Lys 
            660                 665                 670         


Leu Pro Thr Ser Met Lys Arg Val Ala Glu Leu Val Gly Val Glu Glu 
        675                 680                 685             


Gly Phe Leu Ala Arg Cys Val Lys Gly Lys Val Val Ala Arg Thr Glu 
    690                 695                 700                 


Arg Gln His Arg Gln Met Ala Ile His Lys Arg Phe Phe Thr Ser Leu 
705                 710                 715                 720 


Val Leu Leu Asp Leu Ile Ser Glu Ile Pro Leu Lys Asp Ile Asn Gln 
                725                 730                 735     


Lys Tyr Gly Cys Asn Arg Gly Gln Ile Gln Ser Leu Gln Gln Ser Ala 
            740                 745                 750         


Ala Val Tyr Ala Gly Met Ile Thr Val Phe Ser Asn Arg Leu Gly Trp 
        755                 760                 765             


His Asn Met Glu Leu Leu Leu Ser Gln Phe Gln Lys Arg Leu Thr Phe 
    770                 775                 780                 


Gly Ile Gln Arg Glu Leu Cys Asp Leu Ile Arg Val Ser Leu Leu Asn 
785                 790                 795                 800 


Ala Gln Arg Ala Arg Phe Leu Tyr Ala Ser Gly Phe Leu Thr Val Ala 
                805                 810                 815     


Asp Leu Ala Arg Ala Asp Ser Ala Glu Val Glu Val Ala Leu Lys Asn 
            820                 825                 830         


Ser Leu Pro Phe Lys Ser Ala Arg Lys Ala Val Asp Glu Glu Glu Glu 
        835                 840                 845             


Ala Ala Glu Glu Arg Arg Ser Met Arg Thr Ile Trp Val Thr Gly Lys 
    850                 855                 860                 


Gly Leu Ser Ala Arg Glu Ala Ala Ala Leu Ile Val Glu Glu Ala Lys 
865                 870                 875                 880 


Met Ile Leu Gln Gln Asp Leu Ile Glu Met Gly Val Arg Trp Asp Pro 
                885                 890                 895     


Lys Ser Pro Leu Ser Ser Ser Thr His Ser Arg Thr Ser Thr Ser Glu 
            900                 905                 910         


Val Lys Glu His Thr Phe Lys Ser Gln Thr Lys Ser Ser His Lys Arg 
        915                 920                 925             


Leu Ala Ser Met Gly Arg Asn Ser Ile Arg Ala Ser Gly Ser Asn Asp 
    930                 935                 940                 


Lys Pro Ser Pro Asp Ala Glu Arg Gly Ile Asp Asp Cys Ser Glu His 
945                 950                 955                 960 


Ala Asp Ser Leu Cys Lys Phe Gln Gly Asn Phe Glu Pro Gln Thr Pro 
                965                 970                 975     


Ser Ile Cys Thr Ala Arg Lys Arg Thr Ser Leu Gly Ile Asn Lys Glu 
            980                 985                 990         


Met Leu Arg Lys Ser Leu Lys Glu  Gly Lys Pro Ser Thr  Lys Glu Val 
        995                 1000                 1005             


Leu Gln  Thr Phe Ser Ser Glu  Lys Thr Arg Lys Thr  Ala Leu Ser 
    1010                 1015                 1020             


Phe Ser  Ser Glu Gln Val Asn  Asn Thr Leu Pro Ser  Gly Arg Asp 
    1025                 1030                 1035             


Arg Lys  Tyr Gln Lys Lys Ser  Trp Gly Ser Ser Pro  Val Arg Asp 
    1040                 1045                 1050             


Ser Gly  Met His Arg Gly Asp  Leu Gln Gly Gln Thr  Met Cys Thr 
    1055                 1060                 1065             


Ser Ala  Leu Cys Glu Asp Ser  Gln Lys Ser Leu Glu  Glu Gln Asn 
    1070                 1075                 1080             


Ala Glu  Phe Arg Ser Pro Gly  Leu Phe Ala Lys His  Leu Pro Ser 
    1085                 1090                 1095             


Cys Ala  Lys Glu Lys Cys Lys  Lys Pro Ser Leu Pro  Leu Gln Arg 
    1100                 1105                 1110             


Gln Gln  Ala Cys Ser Arg Arg  Ser Thr Glu Ser Cys  Ala Ala Val 
    1115                 1120                 1125             


Gly His  Pro Ala Ala Gly Ser  Ser Pro Ala Ala Ala  Arg Asp Arg 
    1130                 1135                 1140             


Arg Gly  Leu Ala Ala Arg Glu  Thr Glu Lys Gly Asn  Glu Ala Leu 
    1145                 1150                 1155             


Thr Glu  Asn Gly Gly Glu Ser  Gln Leu Gln Asp Thr  Tyr Pro Val 
    1160                 1165                 1170             


Ser Gln  Tyr Leu Glu Tyr His  Ser Glu Lys His Thr  Asn Thr Cys 
    1175                 1180                 1185             


Thr Arg  Gln Lys Thr Leu Thr  Glu Gly Gln Ala Gly  Ser Ser Tyr 
    1190                 1195                 1200             


Val Ala  Arg Asp Ser Asn Asp  Ala Ala Pro Ile Lys  Cys Glu Arg 
    1205                 1210                 1215             


Met Lys  Leu Asn Ser Lys Asp  Arg Asp Ser Asn Pro  Cys Arg Gln 
    1220                 1225                 1230             


Ala Leu  Gly Ser Tyr Thr Gly  Arg Thr Glu Ala Leu  Gln Ser Thr 
    1235                 1240                 1245             


Ala Lys  Leu Gly Gln Ala Gly  Gly Gln Cys Glu Asn  Leu Leu Asn 
    1250                 1255                 1260             


Ser Ser  Gly Val Gln Gly Lys  Thr Gly Ala His Ala  Thr Asn Arg 
    1265                 1270                 1275             


Thr Glu  His Ser His Ala Ser  Asn Pro Ala Phe Cys  Asp Phe Gly 
    1280                 1285                 1290             


Asp Ser  Leu Asp Leu Asp Thr  Gln Ser Glu Glu Ile  Ile Glu Gln 
    1295                 1300                 1305             


Met Ala  Thr Glu Asn Thr Met  Gln Gly Ala Lys Ala  Val Val Ile 
    1310                 1315                 1320             


Met Glu  Glu Gly Ser Ala Met  Gln Asn Lys Cys His  Ser Thr Pro 
    1325                 1330                 1335             


Gly Asp  Gln His Val Pro Gly  Ala Ala Asn Thr Asp  His Val Asp 
    1340                 1345                 1350             


Ser Lys  Lys Val Glu Ser Val  Lys Ala Asn Thr Glu  Lys Asn Ile 
    1355                 1360                 1365             


Asn Arg  Gly Ala Pro Val Ser  Leu Ile Phe His Thr  Gln Gly Glu 
    1370                 1375                 1380             


Asn Gly  Ala Cys Phe Lys Gly  Asn Glu His Ser Val  Thr Asp Ser 
    1385                 1390                 1395             


Gln Leu  Asn Ser Phe Leu Gln  Gly Phe Glu Thr Gln  Glu Ile Val 
    1400                 1405                 1410             


Lys Pro  Ile Ile Pro Leu Ala  Pro Gln Met Arg Thr  Pro Thr Gly 
    1415                 1420                 1425             


Val Glu  Glu Glu Ser Leu Pro  Glu Thr Ser Leu Asn  Met Ser Asp 
    1430                 1435                 1440             


Ser Ile  Leu Phe Asp Ser Phe  Gly Glu Asp Gly Phe  Gly Gln Gly 
    1445                 1450                 1455             


Gln Ser  Pro Asp Ile Lys Ala  Asn Gln Pro Leu Leu  Ser Glu Met 
    1460                 1465                 1470             


Thr Pro  Asn His Phe Ser Asn  Pro Pro His Pro Gln  Glu Asp Pro 
    1475                 1480                 1485             


Val Met  Thr Pro Thr Val Ser  Glu Pro Gln Gly Thr  Gln Gln Gln 
    1490                 1495                 1500             


Gly Val  Cys Leu Ser Gly Glu  Ser Ile Ile Phe Ser  Asp Ile Asp 
    1505                 1510                 1515             


Ser Ala  Gln Val Ile Glu Ala  Leu Asp Asn Met Ala  Ala Phe His 
    1520                 1525                 1530             


Val Gln  Glu Asn Cys Asn Ser  Val Ala Leu Lys Thr  Leu Glu Pro 
    1535                 1540                 1545             


Ser Asp  Ser Ala Val Leu Gly  Asn Glu Cys Pro Gln  Gly Lys Leu 
    1550                 1555                 1560             


Val Arg  Gly Asp Gln Asn Glu  Gly Ser Pro Lys Pro  Lys Leu Thr 
    1565                 1570                 1575             


Glu Thr  Asn Gln Asp Asn Ser  Phe Thr Trp Ser Gly  Ala Ser Phe 
    1580                 1585                 1590             


Asn Leu  Ser Pro Glu Leu Gln  Arg Ile Leu Asp Lys  Val Ser Ser 
    1595                 1600                 1605             


Pro Arg  Glu Asn Glu Lys Pro  Lys Met Ile His Val  Asn Leu Ser 
    1610                 1615                 1620             


Ser Phe  Glu Gly Asn Ser Lys  Glu Ser His Glu Arg  Glu Glu Ile 
    1625                 1630                 1635             


Asn Ser  Asp Leu Gly Thr Val  Gln Arg Thr Ser Val  Phe Pro Ser 
    1640                 1645                 1650             


Asn Glu  Val Lys Asn Arg Thr  Glu Gly Leu Glu Ser  Lys Ala Arg 
    1655                 1660                 1665             


His Gly  Gly Ala Ser Ser Pro  Leu Pro Arg Lys Glu  Ser Ala Ala 
    1670                 1675                 1680             


Ala Asp  Asp Asn Gly Leu Ile  Pro Pro Thr Pro Val  Pro Ala Ser 
    1685                 1690                 1695             


Ala Ser  Lys Val Ala Phe Pro  Glu Ile Leu Gly Thr  Ser Val Lys 
    1700                 1705                 1710             


Arg Gln  Lys Ala Ser Ser Ala  Leu Gln Pro Gly Glu  Ser Cys Leu 
    1715                 1720                 1725             


Phe Gly  Ser Pro Ser Asp Asn  Gln Asn Gln Asp Leu  Ser Gln Glu 
    1730                 1735                 1740             


Leu Arg  Asp Ser Leu Lys Asp  Tyr Asp Gly Ser Val  Ala Asp Thr 
    1745                 1750                 1755             


Ser Phe  Phe Leu Gln Ser Gln  Asp Gly Leu Leu Leu  Thr Gln Ala 
    1760                 1765                 1770             


Ser Cys  Ser Ser Glu Ser Leu  Ala Ile Ile Asp Val  Ala Ser Asp 
    1775                 1780                 1785             


Gln Ile  Leu Phe Gln Thr Phe  Val Lys Glu Trp Gln  Cys Gln Lys 
    1790                 1795                 1800             


Arg Phe  Ser Ile Ser Leu Ala  Cys Glu Lys Met Thr  Ser Ser Met 
    1805                 1810                 1815             


Ser Ser  Lys Thr Ala Thr Ile  Gly Gly Lys Leu Lys  Gln Val Ser 
    1820                 1825                 1830             


Leu Pro  Gln Glu Ala Thr Val  Glu Asp Ala Gly Phe  Pro Val Arg 
    1835                 1840                 1845             


Gly Cys  Asp Gly Ala Val Val  Val Gly Leu Ala Val  Cys Trp Gly 
    1850                 1855                 1860             


Ala Lys  Asp Ala Tyr Tyr Leu  Ser Leu Gln Lys Glu  Gln Lys Gln 
    1865                 1870                 1875             


Ser Glu  Ile Ser Pro Ser Leu  Ala Pro Pro Pro Leu  Asp Ala Thr 
    1880                 1885                 1890             


Leu Thr  Val Lys Glu Arg Met  Glu Cys Leu Gln Ser  Cys Leu Gln 
    1895                 1900                 1905             


Lys Lys  Ser Asp Arg Glu Arg  Ser Val Val Thr Tyr  Asp Phe Ile 
    1910                 1915                 1920             


Gln Thr  Tyr Lys Val Leu Leu  Leu Ser Cys Gly Ile  Ser Leu Glu 
    1925                 1930                 1935             


Pro Ser  Tyr Glu Asp Pro Lys  Val Ala Cys Trp Leu  Leu Asp Pro 
    1940                 1945                 1950             


Asp Ser  Lys Glu Pro Thr Leu  His Ser Ile Val Thr  Ser Phe Leu 
    1955                 1960                 1965             


Pro His  Glu Leu Ala Leu Leu  Glu Gly Met Glu Thr  Gly Pro Gly 
    1970                 1975                 1980             


Ile Gln  Ser Leu Gly Leu Asn  Val Asn Thr Glu His  Ser Gly Arg 
    1985                 1990                 1995             


Tyr Arg  Ala Ser Val Glu Ser  Val Leu Ile Phe Asn  Ser Met Asn 
    2000                 2005                 2010             


Gln Leu  Asn Ser Leu Leu Gln  Lys Glu Asn Leu His  Asp Ile Phe 
    2015                 2020                 2025             


Cys Lys  Val Glu Met Pro Ser  Gln Tyr Cys Leu Ala  Leu Leu Glu 
    2030                 2035                 2040             


Leu Asn  Gly Ile Gly Phe Ser  Thr Ala Glu Cys Glu  Ser Gln Lys 
    2045                 2050                 2055             


His Val  Met Gln Ala Lys Leu  Asp Ala Ile Glu Thr  Gln Ala Tyr 
    2060                 2065                 2070             


Gln Leu  Ala Gly His Ser Phe  Ser Phe Thr Ser Ala  Asp Asp Ile 
    2075                 2080                 2085             


Ala Gln  Val Leu Phe Leu Glu  Leu Lys Leu Pro Pro  Asn Gly Glu 
    2090                 2095                 2100             


Met Lys  Thr Gln Gly Ser Lys  Lys Thr Leu Gly Ser  Thr Arg Arg 
    2105                 2110                 2115             


Gly Asn  Glu Ser Gly Arg Arg  Met Arg Leu Gly Arg  Gln Phe Ser 
    2120                 2125                 2130             


Thr Ser  Lys Asp Ile Leu Asn  Lys Leu Lys Gly Leu  His Pro Leu 
    2135                 2140                 2145             


Pro Gly  Leu Ile Leu Glu Trp  Arg Arg Ile Ser Asn  Ala Ile Thr 
    2150                 2155                 2160             


Lys Val  Val Phe Pro Leu Gln  Arg Glu Lys His Leu  Asn Pro Leu 
    2165                 2170                 2175             


Leu Arg  Met Glu Arg Ile Tyr  Pro Val Ser Gln Ser  His Thr Ala 
    2180                 2185                 2190             


Thr Gly  Arg Ile Thr Phe Thr  Glu Pro Asn Ile Gln  Asn Val Pro 
    2195                 2200                 2205             


Arg Asp  Phe Glu Ile Lys Met  Pro Thr Leu Val Arg  Glu Ser Pro 
    2210                 2215                 2220             


Pro Ser  Gln Ala Pro Lys Gly  Arg Phe Pro Met Ala  Ile Gly Gln 
    2225                 2230                 2235             


Asp Lys  Lys Val Tyr Gly Leu  His Pro Gly His Arg  Thr Gln Met 
    2240                 2245                 2250             


Glu Glu  Lys Ala Ser Asp Arg  Gly Val Pro Phe Ser  Val Ser Met 
    2255                 2260                 2265             


Arg His  Ala Phe Val Pro Phe  Pro Gly Gly Leu Ile  Leu Ala Ala 
    2270                 2275                 2280             


Asp Tyr  Ser Gln Leu Glu Leu  Arg Ile Leu Ala His  Leu Ser Arg 
    2285                 2290                 2295             


Asp Cys  Arg Leu Ile Gln Val  Leu Asn Thr Gly Ala  Asp Val Phe 
    2300                 2305                 2310             


Arg Ser  Ile Ala Ala Glu Trp  Lys Met Ile Glu Pro  Asp Ala Val 
    2315                 2320                 2325             


Gly Asp  Asp Leu Arg Gln His  Ala Lys Gln Ile Cys  Tyr Gly Ile 
    2330                 2335                 2340             


Ile Tyr  Gly Met Gly Ala Lys  Ser Leu Gly Glu Gln  Met Gly Ile 
    2345                 2350                 2355             


Lys Glu  Asn Asp Ala Ala Ser  Tyr Ile Asp Ser Phe  Lys Ser Arg 
    2360                 2365                 2370             


Tyr Lys  Gly Ile Asn His Phe  Met Arg Asp Thr Val  Lys Asn Cys 
    2375                 2380                 2385             


Arg Lys  Asn Gly Phe Val Glu  Thr Ile Leu Gly Arg  Arg Arg Tyr 
    2390                 2395                 2400             


Leu Pro  Gly Ile Lys Asp Asp  Asn Pro Tyr His Lys  Ala His Ala 
    2405                 2410                 2415             


Glu Arg  Gln Ala Ile Asn Thr  Thr Val Gln Gly Ser  Ala Ala Asp 
    2420                 2425                 2430             


Ile Val  Lys Ile Ala Thr Val  Asn Ile Gln Lys Gln  Leu Glu Thr 
    2435                 2440                 2445             


Phe Arg  Ser Thr Phe Lys Ser  His Gly His Arg Glu  Ser Met Leu 
    2450                 2455                 2460             


Gln Asn  Asp Arg Thr Gly Leu  Leu Pro Lys Arg Lys  Leu Lys Gly 
    2465                 2470                 2475             


Met Phe  Cys Pro Met Arg Gly  Gly Phe Phe Ile Leu  Gln Leu His 
    2480                 2485                 2490             


Asp Glu  Leu Leu Tyr Glu Val  Ala Glu Glu Asp Val  Val Gln Val 
    2495                 2500                 2505             


Ala Gln  Ile Val Lys Asn Glu  Met Glu Cys Ala Ile  Lys Leu Ser 
    2510                 2515                 2520             


Val Lys  Leu Lys Val Lys Val  Lys Ile Gly Ala Ser  Trp Gly Glu 
    2525                 2530                 2535             


Leu Lys  Asp Phe Asp Val 
    2540                 


<210>  3
<211>  2579
<212>  PRT
<213>  Danio rerio

<400>  3

Met Met Thr Ser Thr Thr Arg Lys Ile Tyr Leu Gly Gln His Arg Ile 
1               5                   10                  15      


Val Lys Thr Arg Gly Leu Ser Leu Ala Asp Glu Lys Pro Gly Gln Arg 
            20                  25                  30          


Gln Leu Ser Asn Leu Cys Gln Glu Asp Val Ser Glu Asn Arg Ser Cys 
        35                  40                  45              


Ile Ala Pro Lys Gln Ile Gln Ser Lys Gln Trp Met Pro Gly Asp Ser 
    50                  55                  60                  


Ser Leu Ala Met Asp Glu Glu Ile Leu Gln Ala Ile Asp Glu Leu Gly 
65                  70                  75                  80  


Pro Glu Val Leu Lys Phe Lys Lys Ile Glu Lys Ile Gln Gln Thr Glu 
                85                  90                  95      


Pro Ala Pro Leu Lys Lys Asn Cys Asp Phe Pro Lys Ile Pro Glu Ile 
            100                 105                 110         


Gln Lys Glu Gln Asn Thr Glu Asn Ile Ser Pro Ser Ser Pro Ser Glu 
        115                 120                 125             


His Lys Arg Thr Arg Thr Gln Ala Lys Lys Glu Gly Asp Trp Lys Asp 
    130                 135                 140                 


Leu Ala Gln Lys Leu Leu Phe Ser Glu Thr Lys Lys Ile Glu Val Gly 
145                 150                 155                 160 


Gly Arg Thr His Asp Leu Lys Gln Asn Arg Asp Tyr Ser Ser Pro Gln 
                165                 170                 175     


Lys Ile Leu Asn Ser Met Lys Lys Thr Ser Lys Val Ala Lys Ser Lys 
            180                 185                 190         


Gln Lys Leu Asn Phe Arg Glu Val Thr Ser Pro Asn Asp Ser Lys Asp 
        195                 200                 205             


Tyr Ile Leu Phe Ser Pro Thr His Met Ala Ala Ala Lys Glu Arg Ser 
    210                 215                 220                 


Val Leu Gln Gln Gln Lys Arg Ser Leu Lys Asn Gln Ser Val Ser Val 
225                 230                 235                 240 


Leu Thr Pro Pro Pro Gly Leu Asp Leu Thr Val Leu Gly Asp Ala Thr 
                245                 250                 255     


Leu Ser Asp Ala Ala Gln Ser Ile His Met Gly Arg Pro Ala Asp Gln 
            260                 265                 270         


Leu Asp Lys Leu Leu Leu Ser Ser Trp Gly Leu Pro Lys Pro Val Leu 
        275                 280                 285             


Glu Lys Tyr Gln Ser Leu Gly Val His Arg Met Phe Glu Trp Gln Ala 
    290                 295                 300                 


Glu Cys Leu Thr Leu Gly Lys Val Leu Glu Gly Gln Asn Leu Val Tyr 
305                 310                 315                 320 


Ser Ala Pro Thr Ser Ala Gly Lys Thr Leu Val Ser Glu Leu Leu Ile 
                325                 330                 335     


Leu Lys Arg Val Leu Glu Thr Arg Gln Lys Ala Met Phe Ile Leu Pro 
            340                 345                 350         


Phe Val Ser Val Ala Arg Glu Lys Met Phe Tyr Leu Gln Asn Val Phe 
        355                 360                 365             


Gln Glu Ala Gly Ile Arg Val Glu Gly Tyr Met Gly Ser Thr Ser Ala 
    370                 375                 380                 


Ala Gly Gly Phe Ser Ala Leu Asp Val Ala Val Cys Thr Ile Glu Lys 
385                 390                 395                 400 


Ala Asn Gly Leu Val Asn Arg Leu Ile Glu Glu Asp Lys Leu Asp Leu 
                405                 410                 415     


Leu Gly Thr Val Val Val Asp Glu Leu His Met Val Gly Asp Ser Gly 
            420                 425                 430         


Arg Gly Tyr Leu Leu Glu Leu Leu Leu Thr Lys Ile Arg Tyr Ile Ala 
        435                 440                 445             


Gln Lys Thr Ala Thr Arg Asn Ser Gly Gln Ser Thr Ser Thr Gly Val 
    450                 455                 460                 


Gln Ile Ile Gly Met Ser Ala Thr Leu Pro Asn Leu Asp Leu Leu Ala 
465                 470                 475                 480 


Arg Trp Leu Ser Ala Glu Leu Tyr Ser Thr Asn Tyr Arg Pro Val Pro 
                485                 490                 495     


Leu Met Glu Trp Val Lys Ile Gly Thr Asn Ile Tyr Asp Gly Ser Leu 
            500                 505                 510         


Asn Leu Val Arg Gln Phe Thr Pro Ala Leu Pro Ile Lys Gly Asp Asp 
        515                 520                 525             


Asp His Ile Val Ser Leu Cys Phe Glu Thr Val Gln Asp Gly His Ser 
    530                 535                 540                 


Ala Leu Leu Phe Cys Pro Ser Lys Asn Trp Cys Glu Lys Leu Ala Asp 
545                 550                 555                 560 


Ser Ile Gly Arg Glu Phe Tyr Asn Leu His His Lys Glu Met Gln Ser 
                565                 570                 575     


Gly Ser Gly Gly Gln Ser Ile Phe Leu Asn Gln Glu Gly Leu Leu Asp 
            580                 585                 590         


Val Leu Ala Gln Leu Lys Arg Thr Pro Ala Gly Leu Asp His Val Leu 
        595                 600                 605             


Gln Arg Thr Val Pro Trp Gly Val Ala Phe His His Ala Gly Leu Thr 
    610                 615                 620                 


Phe Asp Glu Arg Asp Ile Leu Glu Gly Ala Phe Arg Gln Gly Tyr Ile 
625                 630                 635                 640 


Arg Val Leu Ala Ala Thr Ser Thr Leu Ser Ser Gly Val Asn Leu Pro 
                645                 650                 655     


Ala Arg Arg Val Ile Ile Arg Thr Pro Val Phe Asn Gly His Leu Leu 
            660                 665                 670         


Asp Ile Leu Thr Tyr Lys Gln Met Val Gly Arg Ala Gly Arg Lys Gly 
        675                 680                 685             


Val Asp Thr Ile Gly Glu Ser Val Leu Val Cys Lys Glu Ala Glu Arg 
    690                 695                 700                 


Ala Lys Gly Met Ser Leu Ile Gln Gly Ser Leu Lys Pro Ile Ser Ser 
705                 710                 715                 720 


Cys Leu Val Lys Arg Glu Gly Glu Gly Val Thr Thr Ser Met Leu Arg 
                725                 730                 735     


Ala Ile Leu Glu Ile Ile Val Gly Gly Val Ala Ser Ser Pro Gln Asp 
            740                 745                 750         


Val Arg Met Tyr Ala Ala Cys Thr Leu Leu Ala Ala Ser Ile Ala Ala 
        755                 760                 765             


Glu Glu Ala His Gln Asp Gly Ser Glu Ser Glu Ala Arg Asn Lys Gly 
    770                 775                 780                 


Ala Ile Glu Ala Cys Ile Glu Trp Leu Met Asp Asn Glu Phe Ile His 
785                 790                 795                 800 


Ile Gln Lys Glu Gly Asp Val Glu Arg Tyr Cys Pro Thr His Leu Gly 
                805                 810                 815     


Ser Ala Thr Leu Ser Ser Ser Leu Ser Pro Pro Glu Ala Leu Gly Ile 
            820                 825                 830         


Phe Ala Asp Leu Gln Arg Ala Met Lys Gly Phe Val Leu Glu Asn Asp 
        835                 840                 845             


Leu His Ile Leu Tyr Gln Ile Thr Pro Val Tyr Val Asp Trp Thr Thr 
    850                 855                 860                 


Ile Asp Trp Tyr Gln Phe Phe Cys Leu Trp Glu Gln Leu Pro Ser Ala 
865                 870                 875                 880 


Met Lys Arg Val Ala Glu Met Val Gly Ile Gln Glu Gly Phe Leu Ala 
                885                 890                 895     


Arg Ser Val Gly Gly Lys Leu Ile Ala Lys Thr Glu Lys Gln Arg Arg 
            900                 905                 910         


Gln Met Ala Ile His Lys Arg Phe Phe Thr Thr Leu Val Leu Leu Asp 
        915                 920                 925             


Leu Val Ser Glu Glu Pro Leu Gly Ala Val Ala Lys Lys Tyr Gly Cys 
    930                 935                 940                 


Ser Arg Gly Gln Leu Gln Ser Leu Gln Gln Ser Ala Ser Thr Tyr Ala 
945                 950                 955                 960 


Gly Met Val Thr Val Phe Cys Asn Arg Leu Gly Trp His Asn Leu Glu 
                965                 970                 975     


Leu Leu Leu Ser Gln Phe Gln Ser Arg Leu Ser Phe Gly Val Gln Arg 
            980                 985                 990         


Glu Leu Cys Asp Leu Val Arg Ile  Ser Leu Leu Thr Ala  Gln Arg Ala 
        995                 1000                 1005             


Arg Thr  Leu Tyr Ser Ser Gly  Phe Val Thr Val Ala  Glu Leu Ala 
    1010                 1015                 1020             


Arg Ala  Asp Val Ser Glu Val  Glu Lys Ala Leu Arg  Lys Ala Ile 
    1025                 1030                 1035             


Pro Phe  Lys Ser Ser Arg Gln  Ala Val Asp Glu Ser  Glu Val Glu 
    1040                 1045                 1050             


Ala Gln  Glu Arg Lys Ser Met  Arg Cys Ile Trp Val  Ser Gly Lys 
    1055                 1060                 1065             


Lys Ala  Leu Thr Glu Arg Glu  Ala Ala Gln Gln Ile  Val Ala Glu 
    1070                 1075                 1080             


Ala Gln  Leu Leu Leu Gln Lys  Asp Leu Ala Leu Leu  Gly Val Glu 
    1085                 1090                 1095             


Trp Ser  Pro Ala Cys Leu Pro  Ala Lys Thr Gln Pro  Asp Asn Ser 
    1100                 1105                 1110             


Ser Thr  Val Lys Ser Asn Thr  Glu Pro Arg Ser Met  Ser Gly Gly 
    1115                 1120                 1125             


Thr Glu  His Glu Gly Asp Gln  Asp Leu Met Ser Asn  Val Thr Glu 
    1130                 1135                 1140             


Glu Lys  Leu Leu Leu Glu Asn  Asn Ser Asp Asn Asn  Ser His Pro 
    1145                 1150                 1155             


Pro Leu  Arg Pro Leu Glu Ser  Thr Thr Asn Ser Glu  Lys Thr Met 
    1160                 1165                 1170             


Asp Val  Asp Ser Gly Val Ser  Ser Ala Glu Cys Gln  Pro Asp Lys 
    1175                 1180                 1185             


Lys Cys  Glu Leu Gln Ser Ser  Val Leu His Lys Val  Leu Lys Ser 
    1190                 1195                 1200             


Ile Asn  Thr Lys Asp Lys Gly  Cys Asp Asn Asn His  Thr Val Glu 
    1205                 1210                 1215             


Ser Ser  Ser Glu Thr Leu Gln  Arg Arg Asn Ser Cys  Leu Asn Thr 
    1220                 1225                 1230             


Cys Ile  Ser Gly Asn Asp Gln  His Cys Val Ser Pro  Val Ser Lys 
    1235                 1240                 1245             


Arg Arg  Arg Met Asp Ala Ala  Gly Asp Glu Glu Gly  Pro Thr Val 
    1250                 1255                 1260             


Thr Gly  Val Lys Met Arg Ile  Ala Asn Gly Leu Ala  Thr Asp Arg 
    1265                 1270                 1275             


Lys Glu  Met Pro Lys Pro Glu  Glu Leu Cys Arg Ile  Asp Gln Val 
    1280                 1285                 1290             


Lys Met  Lys Leu Asn Lys Asp  Thr Gly Leu Lys Lys  Asp Ser Arg 
    1295                 1300                 1305             


Ser Cys  Thr Pro Leu Pro Asn  Gly Glu Val Thr Asn  Val Cys Val 
    1310                 1315                 1320             


Phe Ser  Ser Gly Lys Gly Lys  Lys Arg Thr Ser Lys  Met Lys His 
    1325                 1330                 1335             


Leu Asn  Ile Asn Glu Asp Ile  Tyr His Glu Thr Gln  Thr Glu Lys 
    1340                 1345                 1350             


Glu Glu  Met Val Ala Glu Ile  Tyr Gly Lys Phe Ser  Asn Ile Asp 
    1355                 1360                 1365             


Gln Asn  Glu Gly Asp Leu His  Val Asn Thr Arg Val  Lys Asn Asp 
    1370                 1375                 1380             


Leu Val  Cys Asn Ser Glu Lys  Leu Ser Ser Pro Asp  Leu Tyr Thr 
    1385                 1390                 1395             


Asn Gly  Ile Glu Glu Phe Gly  Asp Ser Phe Gln Leu  Asp Thr Gln 
    1400                 1405                 1410             


Thr Glu  Lys Met Leu His Gly  His Asp Phe Ser His  Arg Asn Val 
    1415                 1420                 1425             


Glu Phe  Asn Val Arg Glu Asn  Lys Gln Asp Asn Gln  Val Asp Ser 
    1430                 1435                 1440             


Thr Ser  Glu Lys Val Val Lys  Gln Ser Ser Phe Leu  Glu Lys Glu 
    1445                 1450                 1455             


Asn Arg  Val Ser Lys Glu Gln  Asn Lys Gly Pro Phe  Glu Ser Leu 
    1460                 1465                 1470             


Ser Leu  His Asp Asn Gly Trp  Pro Thr Glu Ala Lys  Pro Lys Tyr 
    1475                 1480                 1485             


Asn Ile  Ser Leu Thr Asp Ser  Gln Leu Glu Asn Ile  Leu Asn Tyr 
    1490                 1495                 1500             


Ser Asn  Gln Val Pro Glu Glu  Glu Gln Cys Ala Asn  Lys Pro Ala 
    1505                 1510                 1515             


Glu Gln  Arg Glu Asn Asn Glu  Ser Ser Asp His Val  Thr Asp Asn 
    1520                 1525                 1530             


Ser Phe  Asp Arg Ser Ser Ser  Phe Leu Phe Asp Ser  Leu Tyr Asp 
    1535                 1540                 1545             


Asn Ser  Ile Leu Asp Ala Met  Glu Glu Ala Ala Ile  Asp Gln Asp 
    1550                 1555                 1560             


Asn Lys  Gly Asp Gln Glu Ala  Glu Val Lys Val Asn  Ser Asn Gly 
    1565                 1570                 1575             


Ser Ser  Pro Glu Leu Ile Pro  Glu Arg Arg Glu Ala  Leu Pro Thr 
    1580                 1585                 1590             


Asp Asp  Gln Glu Ala Ile Gln  Trp Gly Glu Ser Ser  Phe Asn Leu 
    1595                 1600                 1605             


Ser Glu  Trp Gly Asp Ser Leu  Ile Ile Gly Glu Gln  Tyr Leu Glu 
    1610                 1615                 1620             


Lys Ile  Ser Lys Ala Cys Asp  Gly Pro Arg Leu Gly  Ala Glu Lys 
    1625                 1630                 1635             


Pro Ser  Tyr Thr Asp Asp Ile  Val Ser Glu Leu Asn  Val Ser Gln 
    1640                 1645                 1650             


Ser Asn  Glu Tyr Gln Gln Lys  Val Glu Arg His Arg  Leu Asn Ser 
    1655                 1660                 1665             


Ser Ser  Phe His Ile Ser Pro  Gly Met Gln Asp Leu  Phe Asp Lys 
    1670                 1675                 1680             


Trp Ser  Asp Gln Phe Ser Thr  Val Pro Asp Ala Thr  Ala His Ser 
    1685                 1690                 1695             


Asn Ser  Leu Val Glu Pro Asn  Ala Val Val Leu Glu  Glu Ala Val 
    1700                 1705                 1710             


Ser Leu  Thr Lys Thr Lys Glu  Ile Glu Lys Glu Gly  Pro Glu Val 
    1715                 1720                 1725             


Ser Arg  Ser Glu Asp Phe Val  Thr Val Gln Ala Lys  Lys Val Thr 
    1730                 1735                 1740             


Pro Ser  Asp Leu Val Pro Pro  Thr Gln Val Leu Glu  Pro Val Thr 
    1745                 1750                 1755             


Pro Arg  Val Lys Met Thr Thr  Ser Ala Ile Gln Ser  Pro Lys Asn 
    1760                 1765                 1770             


Val Thr  Lys Gln Arg Ser Glu  Leu Asp Pro Asn Ile  Lys Ser Cys 
    1775                 1780                 1785             


Thr Gln  Arg Tyr His Gln Pro  Cys Leu Arg Thr Asn  Ser Thr Ser 
    1790                 1795                 1800             


Val Leu  Gly Ala Pro Leu Ala  Asp Glu Gly Phe Thr  Arg Leu Ser 
    1805                 1810                 1815             


Gln Cys  Pro Ser Leu Pro Ala  Ser Asn Ser Cys Ser  Pro Glu Thr 
    1820                 1825                 1830             


Phe Ser  Ile Ile Asp Val Ala  Ser Asp Arg Arg Leu  Phe Glu Thr 
    1835                 1840                 1845             


Phe Val  Asn Glu Trp Lys Thr  Lys Glu Arg Phe Ser  Leu Ala Val 
    1850                 1855                 1860             


Ala Cys  Glu Lys Thr Asp Ser  Thr Ser Val Gln Pro  Glu Thr Val 
    1865                 1870                 1875             


Ile Gly  Gly Lys Phe Lys Lys  Pro Thr Thr Pro Met  Arg Asn Lys 
    1880                 1885                 1890             


Arg Lys  Asp Gly Phe Leu Leu  Lys Gly Tyr Glu Asp  Leu Val Val 
    1895                 1900                 1905             


Ile Gly  Ile Ser Val Ser Trp  Gly Ala Lys Asp Ala  Tyr Phe Val 
    1910                 1915                 1920             


Ser Leu  Gln Gln Glu Leu Val  Asp Thr Asp Ile Ser  Ala Ser Leu 
    1925                 1930                 1935             


Ala Pro  Pro Pro Leu Asp Asp  Thr Leu Thr Val Glu  Glu Arg Leu 
    1940                 1945                 1950             


Lys Gln  Ile Gln Ser Cys Leu  Gln Lys Asp Ser Ser  Val Thr Val 
    1955                 1960                 1965             


Thr Tyr  Asp Phe Ile His Leu  Tyr Lys Ile Leu Leu  Leu Ala Cys 
    1970                 1975                 1980             


Glu Leu  Ala Val Arg Gly Thr  Phe Glu Asp Pro Lys  Ile Ala Cys 
    1985                 1990                 1995             


Trp Leu  Leu Asp Ser Ser Ser  Lys Glu Arg Thr Leu  His Asn Met 
    2000                 2005                 2010             


Val Thr  Ser Phe Ala Thr Glu  Asp Leu Pro Leu Leu  Glu Gly Ile 
    2015                 2020                 2025             


Ser Ala  Gly Gln Gly Val Gln  Ser Leu Gly Ile Phe  Gly Glu Ala 
    2030                 2035                 2040             


Ser Gln  Pro Gly Arg Tyr Arg  Ala Ala Ile Glu Ser  Val Leu Val 
    2045                 2050                 2055             


Phe Arg  Val Met Thr Gln Leu  Asn Cys Leu Leu Glu  Lys Asp Gly 
    2060                 2065                 2070             


Phe Leu  Asp Val Phe Lys Lys  Val Glu Met Pro Thr  Gln Tyr Cys 
    2075                 2080                 2085             


Leu Ala  Leu Leu Glu Leu Asn  Gly Ile Gly Phe Ser  Ile Ala Glu 
    2090                 2095                 2100             


Cys Glu  Ala Gln Lys His Val  Met Gln Ala Lys Leu  Ser Ala Leu 
    2105                 2110                 2115             


Glu Ser  Gln Ala Tyr Gln Leu  Ala Gly His Ser Phe  Ser Leu Thr 
    2120                 2125                 2130             


Ser Pro  Glu Asp Val Ala Glu  Val Leu Phe Leu Glu  Leu Lys Leu 
    2135                 2140                 2145             


Pro Pro  Asn Gly Asp Leu Asn  Gly Leu Lys Asn Lys  Lys Thr Leu 
    2150                 2155                 2160             


Gly Tyr  Thr Arg Arg Ala Gly  Ala Arg Ile Lys Leu  Ser Lys Gln 
    2165                 2170                 2175             


Phe Ser  Thr Thr Lys Asp Val  Leu Glu Lys Leu Lys  Pro Leu His 
    2180                 2185                 2190             


Pro Leu  Pro Gly Val Ile Leu  Glu Trp Arg Arg Ile  Thr Asn Ala 
    2195                 2200                 2205             


Leu Thr  Lys Val Val Phe Pro  Leu Gln Arg Glu Lys  Lys Trp His 
    2210                 2215                 2220             


Ser His  Leu Lys Met Asp Arg  Ile His Pro Ile Ser  Gln Ser His 
    2225                 2230                 2235             


Thr Ala  Thr Gly Arg Val Ser  Phe Thr Glu Pro Asn  Ile Gln Asn 
    2240                 2245                 2250             


Val Pro  Lys Asp Phe Glu Ile  Gln Met Pro Thr Leu  Ile Glu Glu 
    2255                 2260                 2265             


Ser Gln  Thr Ser Gln Asn Gly  Gly Ser Lys Met Trp  Cys Lys Arg 
    2270                 2275                 2280             


Thr Lys  Ile Asn Arg Gln Leu  Ala Pro Leu Leu Lys  Val Ser Asp 
    2285                 2290                 2295             


Lys Ser  Pro Asp Lys Gly Met  Gln Phe Ser Val Ser  Met Arg His 
    2300                 2305                 2310             


Ala Phe  Val Pro Phe Ser Gly  Gly Leu Ile Leu Ala  Val Asp Tyr 
    2315                 2320                 2325             


Ser Gln  Leu Glu Leu Arg Ile  Leu Ala His Leu Ser  Arg Asp Arg 
    2330                 2335                 2340             


Arg Leu  Leu His Val Leu Asn  Ser Gly Ala Asp Val  Phe Lys Ser 
    2345                 2350                 2355             


Ile Ala  Ala Glu Trp Lys Met  Val Asp Pro Ala Ser  Val Asp Asp 
    2360                 2365                 2370             


Asn Met  Arg Gln Gln Ala Lys  Gln Ile Cys Tyr Gly  Ile Ile Tyr 
    2375                 2380                 2385             


Gly Met  Gly Ala Lys Ser Leu  Gly Glu Gln Met Gly  Ile Glu Glu 
    2390                 2395                 2400             


Asn Asp  Ala Ala Cys Tyr Ile  Glu Thr Phe Lys Ser  Arg Tyr Asn 
    2405                 2410                 2415             


Gly Ile  Gln Asn Phe Leu Arg  Glu Thr Val Gln Lys  Cys Gly Lys 
    2420                 2425                 2430             


Asn Gly  Tyr Val Lys Thr Leu  Leu Gly Arg Lys Arg  Phe Leu Pro 
    2435                 2440                 2445             


Gly Ile  Lys Asp Ser Asn Val  Tyr Ile Lys Ser His  Ala Glu Arg 
    2450                 2455                 2460             


Gln Ala  Val Asn Thr Thr Val  Gln Gly Ser Ala Ala  Asp Ile Val 
    2465                 2470                 2475             


Lys Leu  Ala Thr Ile Asn Ile  Gln Arg Arg Ile Glu  Glu Ala Phe 
    2480                 2485                 2490             


Pro Gly  Val Pro Thr Ser His  Gln His Pro Ser Ile  Arg Leu Gly 
    2495                 2500                 2505             


Gly Arg  His Arg Asn Gln Phe  Arg Pro Leu Arg Gly  Gly Tyr Phe 
    2510                 2515                 2520             


Ile Leu  Gln Leu His Asp Glu  Leu Ile Tyr Glu Val  Ala Glu Glu 
    2525                 2530                 2535             


Asp Val  Ile Gln Val Ala Gln  Ile Val Lys Arg Glu  Met Glu Ser 
    2540                 2545                 2550             


Val Val  Lys Leu Tyr Val Lys  Leu Arg Val Lys Val  Lys Val Gly 
    2555                 2560                 2565             


Pro Ser  Trp Gly Asn Leu Gln  Asp Leu Asp Ile 
    2570                 2575                 


<210>  4
<211>  2059
<212>  PRT
<213>  Drosophila melanogaster

<400>  4

Met Ala Phe Ser Gln Ser Phe Asn Phe Gly Asn Ser Thr Leu Met Ala 
1               5                   10                  15      


Leu Glu Lys Gly Met Gln Ala Asp Asp Lys Glu Asn Ala Gln Pro Gly 
            20                  25                  30          


Asn Gly Asn Ile Gln Val Gln Ser Ala Gly Asn Glu Val Asn Ser Glu 
        35                  40                  45              


Ile Gln Glu Ile Asn Ser Glu Phe Phe Arg Asp Glu Phe Ser Tyr Glu 
    50                  55                  60                  


Val Asn Gln Ala His Lys Pro Ala Glu Gln Ser Val Val Asn Val Ser 
65                  70                  75                  80  


Gln Val Gln Gln His Met Ala Val Val Ser Asn Gln Asp Ser Glu Asp 
                85                  90                  95      


Gln Ser Arg Ser Ser Ala Leu Asn Asp Gln Ile Cys Thr Gln Ser Ser 
            100                 105                 110         


Phe Glu Gly Glu Asp Ala Gly Ala Asp Ala Val Leu Asp Gln Pro Asn 
        115                 120                 125             


Leu Asp Glu Asn Ser Phe Leu Cys Pro Ala Gln Asp Glu Glu Ala Ser 
    130                 135                 140                 


Glu Gln Leu Lys Glu Asp Ile Leu His Ser His Ser Val Leu Ala Lys 
145                 150                 155                 160 


Gln Glu Phe Tyr Gln Glu Ile Ser Gln Val Thr Gln Asn Leu Ser Ser 
                165                 170                 175     


Met Ser Pro Asn Gln Leu Arg Val Ser Pro Asn Ser Ser Arg Ile Arg 
            180                 185                 190         


Glu Ala Met Pro Glu Arg Pro Ala Met Pro Leu Asp Leu Asn Thr Leu 
        195                 200                 205             


Arg Ser Ile Ser Ala Trp Asn Leu Pro Met Ser Ile Gln Ala Glu Tyr 
    210                 215                 220                 


Lys Lys Lys Gly Val Val Asp Met Phe Asp Trp Gln Val Glu Cys Leu 
225                 230                 235                 240 


Ser Lys Pro Arg Leu Leu Phe Glu His Cys Asn Leu Val Tyr Ser Ala 
                245                 250                 255     


Pro Thr Ser Ala Gly Lys Thr Leu Val Ser Glu Ile Leu Met Leu Lys 
            260                 265                 270         


Thr Val Leu Glu Arg Gly Lys Lys Val Leu Leu Ile Leu Pro Phe Ile 
        275                 280                 285             


Ser Val Val Arg Glu Lys Met Phe Tyr Met Gln Asp Leu Leu Thr Pro 
    290                 295                 300                 


Ala Gly Tyr Arg Val Glu Gly Phe Tyr Gly Gly Tyr Thr Pro Pro Gly 
305                 310                 315                 320 


Gly Phe Glu Ser Leu His Val Ala Ile Cys Thr Ile Glu Lys Ala Asn 
                325                 330                 335     


Ser Ile Val Asn Lys Leu Met Glu Gln Gly Lys Leu Glu Thr Ile Gly 
            340                 345                 350         


Met Val Val Val Asp Glu Val His Leu Ile Ser Asp Lys Gly Arg Gly 
        355                 360                 365             


Tyr Ile Leu Glu Leu Leu Leu Ala Lys Ile Leu Tyr Met Ser Arg Arg 
    370                 375                 380                 


Asn Gly Leu Gln Ile Gln Val Ile Thr Met Ser Ala Thr Leu Glu Asn 
385                 390                 395                 400 


Val Gln Leu Leu Gln Ser Trp Leu Asp Ala Glu Leu Tyr Ile Thr Asn 
                405                 410                 415     


Tyr Arg Pro Val Ala Leu Lys Glu Met Ile Lys Val Gly Thr Val Ile 
            420                 425                 430         


Tyr Asp His Arg Leu Lys Leu Val Arg Asp Val Ala Lys Gln Lys Val 
        435                 440                 445             


Leu Leu Lys Gly Leu Glu Asn Asp Ser Asp Asp Val Ala Leu Leu Cys 
    450                 455                 460                 


Ile Glu Thr Leu Leu Glu Gly Cys Ser Val Ile Val Phe Cys Pro Ser 
465                 470                 475                 480 


Lys Asp Trp Cys Glu Asn Leu Ala Val Gln Leu Ala Thr Ala Ile His 
                485                 490                 495     


Val Gln Ile Lys Ser Glu Thr Val Leu Gly Gln Arg Leu Arg Thr Asn 
            500                 505                 510         


Leu Asn Pro Arg Ala Ile Ala Glu Val Lys Gln Gln Leu Arg Asp Ile 
        515                 520                 525             


Pro Thr Gly Leu Asp Gly Val Met Ser Lys Ala Ile Thr Tyr Ala Cys 
    530                 535                 540                 


Ala Phe His His Ala Gly Leu Thr Thr Glu Glu Arg Asp Ile Ile Glu 
545                 550                 555                 560 


Ala Ser Phe Lys Ala Gly Ala Leu Lys Val Leu Val Ala Thr Ser Thr 
                565                 570                 575     


Leu Ser Ser Gly Val Asn Leu Pro Ala Arg Arg Val Leu Ile Arg Ser 
            580                 585                 590         


Pro Leu Phe Gly Gly Lys Gln Met Ser Ser Leu Thr Tyr Arg Gln Met 
        595                 600                 605             


Ile Gly Arg Ala Gly Arg Met Gly Lys Asp Thr Leu Gly Glu Ser Ile 
    610                 615                 620                 


Leu Ile Cys Asn Glu Ile Asn Ala Arg Met Gly Arg Asp Leu Val Val 
625                 630                 635                 640 


Ser Glu Leu Gln Pro Ile Thr Ser Cys Leu Asp Met Asp Gly Ser Thr 
                645                 650                 655     


His Leu Lys Arg Ala Leu Leu Glu Val Ile Ser Ser Gly Val Ala Asn 
            660                 665                 670         


Thr Lys Glu Asp Ile Asp Phe Phe Val Asn Cys Thr Leu Leu Ser Ala 
        675                 680                 685             


Gln Lys Ala Phe His Ala Lys Glu Lys Pro Pro Asp Glu Glu Ser Asp 
    690                 695                 700                 


Ala Asn Tyr Ile Asn Asp Ala Leu Asp Phe Leu Val Glu Tyr Glu Phe 
705                 710                 715                 720 


Val Arg Leu Gln Arg Asn Glu Glu Arg Glu Thr Ala Val Tyr Val Ala 
                725                 730                 735     


Thr Arg Leu Gly Ala Ala Cys Leu Ala Ser Ser Met Pro Pro Thr Asp 
            740                 745                 750         


Gly Leu Ile Leu Phe Ala Glu Leu Gln Lys Ser Arg Arg Ser Phe Val 
        755                 760                 765             


Leu Glu Ser Glu Leu His Ala Val Tyr Leu Val Thr Pro Tyr Ser Val 
    770                 775                 780                 


Cys Tyr Gln Leu Gln Asp Ile Asp Trp Leu Leu Tyr Val His Met Trp 
785                 790                 795                 800 


Glu Lys Leu Ser Ser Pro Met Lys Lys Val Gly Glu Leu Val Gly Val 
                805                 810                 815     


Arg Asp Ala Phe Leu Tyr Lys Ala Leu Arg Gly Gln Thr Lys Leu Asp 
            820                 825                 830         


Tyr Lys Gln Met Gln Ile His Lys Arg Phe Tyr Ile Ala Leu Ala Leu 
        835                 840                 845             


Glu Glu Leu Val Asn Glu Thr Pro Ile Asn Val Val Val His Lys Tyr 
    850                 855                 860                 


Lys Cys His Arg Gly Met Leu Gln Ser Leu Gln Gln Met Ala Ser Thr 
865                 870                 875                 880 


Phe Ala Gly Ile Val Thr Ala Phe Cys Asn Ser Leu Gln Trp Ser Thr 
                885                 890                 895     


Leu Ala Leu Ile Val Ser Gln Phe Lys Asp Arg Leu Phe Phe Gly Ile 
            900                 905                 910         


His Arg Asp Leu Ile Asp Leu Met Arg Ile Pro Asp Leu Ser Gln Lys 
        915                 920                 925             


Arg Ala Arg Ala Leu Phe Asp Ala Gly Ile Thr Ser Leu Val Glu Leu 
    930                 935                 940                 


Ala Gly Ala Asp Pro Val Glu Leu Glu Lys Val Leu Tyr Asn Ser Ile 
945                 950                 955                 960 


Ser Phe Asp Ser Ala Lys Gln His Asp His Glu Asn Ala Asp Glu Ala 
                965                 970                 975     


Ala Lys Arg Asn Val Val Arg Asn Phe Tyr Ile Thr Gly Lys Ala Gly 
            980                 985                 990         


Met Thr Val Ser Glu Ala Ala Lys  Leu Leu Ile Gly Glu  Ala Arg Gln 
        995                 1000                 1005             


Phe Val  Gln His Glu Ile Gly  Leu Gly Thr Ile Lys  Trp Thr Gln 
    1010                 1015                 1020             


Thr Gln  Ala Gly Val Glu Ile  Ala Ser Arg Ala Ile  His Asp Gly 
    1025                 1030                 1035             


Gly Glu  Val Asp Leu His Met  Ser Leu Glu Glu Glu  Gln Pro Pro 
    1040                 1045                 1050             


Val Lys  Arg Lys Leu Ser Ile  Glu Glu Asn Gly Thr  Ala Asn Ser 
    1055                 1060                 1065             


Gln Lys  Asn Pro Arg Leu Glu  Thr Val Val Asp Thr  Gln Arg Gly 
    1070                 1075                 1080             


Tyr Lys  Val Asp Lys Asn Ile  Ala Asn Gln Ser Lys  Met Asn Pro 
    1085                 1090                 1095             


Asn Leu  Lys Glu Ile Asp Ala  Gln Asn Lys Ala Arg  Arg Asn Ser 
    1100                 1105                 1110             


Thr Ala  His Met Asp Asn Leu  Asn Pro Ile Ser Asn  Asp Pro Cys 
    1115                 1120                 1125             


Gln Asn  Asn Val Asn Val Lys  Thr Ala Gln Pro Ile  Ile Ser Asn 
    1130                 1135                 1140             


Leu Asn  Asp Ile Gln Lys Gln  Gly Ser Gln Ile Glu  Lys Met Lys 
    1145                 1150                 1155             


Ile Asn  Pro Ala Thr Val Val  Cys Ser Pro Gln Leu  Ala Asn Glu 
    1160                 1165                 1170             


Glu Lys  Pro Ser Thr Ser Gln  Ser Ala Arg Arg Lys  Leu Val Asn 
    1175                 1180                 1185             


Glu Gly  Met Ala Glu Arg Arg  Arg Val Ala Leu Met  Lys Ile Gln 
    1190                 1195                 1200             


Gln Arg  Thr Gln Lys Glu Asn  Gln Ser Lys Asp Gln  Pro Ile Gln 
    1205                 1210                 1215             


Ala Ser  Arg Ser Asn Gln Leu  Ser Ser Pro Val Asn  Arg Thr Pro 
    1220                 1225                 1230             


Ala Asn  Arg Trp Thr Gln Ser  Glu Asn Pro Asn Asn  Glu Met Asn 
    1235                 1240                 1245             


Asn Ser  Gln Leu Pro Arg Arg  Asn Pro Arg Asn Gln  Ser Pro Val 
    1250                 1255                 1260             


Pro Asn  Ala Asn Arg Thr Ala  Ser Arg Lys Val Ser  Asn Ala Glu 
    1265                 1270                 1275             


Glu Asp  Leu Phe Met Ala Asp  Asp Ser Phe Met Leu  Asn Thr Gly 
    1280                 1285                 1290             


Leu Ala  Ala Ala Leu Thr Ala  Ala Glu Ser Lys Ile  Ala Ser Cys 
    1295                 1300                 1305             


Thr Glu  Ala Asp Val Ile Pro  Ser Ser Gln Pro Lys  Glu Pro Glu 
    1310                 1315                 1320             


Val Ile  Gly Ala Leu Thr Pro  His Ala Ser Arg Leu  Lys Arg Ser 
    1325                 1330                 1335             


Asp Gln  Leu Arg Ser Gln Arg  Ile Gln Ser Pro Ser  Pro Thr Pro 
    1340                 1345                 1350             


Gln Arg  Glu Ile Glu Ile Asp  Leu Glu Ser Lys Asn  Glu Ser Asn 
    1355                 1360                 1365             


Gly Val  Ser Ser Met Glu Ile  Ser Asp Met Ser Met  Glu Asn Pro 
    1370                 1375                 1380             


Leu Met  Lys Asn Pro Leu His  Leu Asn Ala Ser His  Ile Met Ser 
    1385                 1390                 1395             


Cys Ser  Lys Val Asp Glu Thr  Ala Ser Ser Phe Ser  Ser Ile Asp 
    1400                 1405                 1410             


Ile Ile  Asp Val Cys Gly His  Arg Asn Ala Phe Gln  Ala Ala Ile 
    1415                 1420                 1425             


Ile Glu  Ile Asn Asn Ala Thr  Arg Leu Gly Phe Ser  Val Gly Leu 
    1430                 1435                 1440             


Gln Ala  Gln Ala Gly Lys Gln  Lys Pro Leu Ile Gly  Ser Asn Leu 
    1445                 1450                 1455             


Leu Ile  Asn Gln Val Ala Ala  Ala Glu Asn Arg Glu  Ala Ala Ala 
    1460                 1465                 1470             


Arg Glu  Arg Val Leu Phe Gln  Val Asp Asp Thr Asn  Phe Ile Ser 
    1475                 1480                 1485             


Gly Val  Ser Phe Cys Leu Ala  Asp Asn Val Ala Tyr  Tyr Trp Asn 
    1490                 1495                 1500             


Met Gln  Ile Asp Glu Arg Ala  Ala Tyr Gln Gly Val  Pro Thr Pro 
    1505                 1510                 1515             


Leu Lys  Val Gln Glu Leu Cys  Asn Leu Met Ala Arg  Lys Asp Leu 
    1520                 1525                 1530             


Thr Leu  Val Met His Asp Gly  Lys Glu Gln Leu Lys  Met Leu Arg 
    1535                 1540                 1545             


Lys Ala  Ile Pro Gln Leu Lys  Arg Ile Ser Ala Lys  Leu Glu Asp 
    1550                 1555                 1560             


Ala Lys  Val Ala Asn Trp Leu  Leu Gln Pro Asp Lys  Thr Val Asn 
    1565                 1570                 1575             


Phe Leu  Asn Met Cys Gln Thr  Phe Ala Pro Glu Cys  Thr Gly Leu 
    1580                 1585                 1590             


Ala Asn  Leu Cys Gly Ser Gly  Arg Gly Tyr Ser Ser  Tyr Gly Leu 
    1595                 1600                 1605             


Asp Thr  Ser Ser Ala Ile Leu  Pro Arg Ile Arg Thr  Ala Ile Glu 
    1610                 1615                 1620             


Ser Cys  Val Thr Leu His Ile  Leu Gln Gly Gln Thr  Glu Asn Leu 
    1625                 1630                 1635             


Ser Arg  Ile Gly Asn Gly Asp  Leu Leu Lys Phe Phe  His Asp Ile 
    1640                 1645                 1650             


Glu Met  Pro Ile Gln Leu Thr  Leu Cys Gln Met Glu  Leu Val Gly 
    1655                 1660                 1665             


Phe Pro  Ala Gln Lys Gln Arg  Leu Gln Gln Leu Tyr  Gln Arg Met 
    1670                 1675                 1680             


Val Ala  Val Met Lys Lys Val  Glu Thr Lys Ile Tyr  Glu Gln His 
    1685                 1690                 1695             


Gly Ser  Arg Phe Asn Leu Gly  Ser Ser Gln Ala Val  Ala Lys Val 
    1700                 1705                 1710             


Leu Gly  Leu His Arg Lys Ala  Lys Gly Arg Val Thr  Thr Ser Arg 
    1715                 1720                 1725             


Gln Val  Leu Glu Lys Leu Asn  Ser Pro Ile Ser His  Leu Ile Leu 
    1730                 1735                 1740             


Gly Tyr  Arg Lys Leu Ser Gly  Leu Leu Ala Lys Ser  Ile Gln Pro 
    1745                 1750                 1755             


Leu Met  Glu Cys Cys Gln Ala  Asp Arg Ile His Gly  Gln Ser Ile 
    1760                 1765                 1770             


Thr Tyr  Thr Ala Thr Gly Arg  Ile Ser Met Thr Glu  Pro Asn Leu 
    1775                 1780                 1785             


Gln Asn  Val Ala Lys Glu Phe  Ser Ile Gln Val Gly  Ser Asp Val 
    1790                 1795                 1800             


Val His  Ile Ser Cys Arg Ser  Pro Phe Met Pro Thr  Asp Glu Ser 
    1805                 1810                 1815             


Arg Cys  Leu Leu Ser Ala Asp  Phe Cys Gln Leu Glu  Met Arg Ile 
    1820                 1825                 1830             


Leu Ala  His Met Ser Gln Asp  Lys Ala Leu Leu Glu  Val Met Lys 
    1835                 1840                 1845             


Ser Ser  Gln Asp Leu Phe Ile  Ala Ile Ala Ala His  Trp Asn Lys 
    1850                 1855                 1860             


Ile Glu  Glu Ser Glu Val Thr  Gln Asp Leu Arg Asn  Ser Thr Lys 
    1865                 1870                 1875             


Gln Val  Cys Tyr Gly Ile Val  Tyr Gly Met Gly Met  Arg Ser Leu 
    1880                 1885                 1890             


Ala Glu  Ser Leu Asn Cys Ser  Glu Gln Glu Ala Arg  Met Ile Ser 
    1895                 1900                 1905             


Asp Gln  Phe His Gln Ala Tyr  Lys Gly Ile Arg Asp  Tyr Thr Thr 
    1910                 1915                 1920             


Arg Val  Val Asn Phe Ala Arg  Ser Lys Gly Phe Val  Glu Thr Ile 
    1925                 1930                 1935             


Thr Gly  Arg Arg Arg Tyr Leu  Glu Asn Ile Asn Ser  Asp Val Glu 
    1940                 1945                 1950             


His Leu  Lys Asn Gln Ala Glu  Arg Gln Ala Val Asn  Ser Thr Ile 
    1955                 1960                 1965             


Gln Gly  Ser Ala Ala Asp Ile  Ala Lys Asn Ala Ile  Leu Lys Met 
    1970                 1975                 1980             


Glu Lys  Asn Ile Glu Arg Tyr  Arg Glu Lys Leu Ala  Leu Gly Asp 
    1985                 1990                 1995             


Asn Ser  Val Asp Leu Val Met  His Leu His Asp Glu  Leu Ile Phe 
    2000                 2005                 2010             


Glu Val  Pro Thr Gly Lys Ala  Lys Lys Ile Ala Lys  Val Leu Ser 
    2015                 2020                 2025             


Leu Thr  Met Glu Asn Cys Val  Lys Leu Ser Val Pro  Leu Lys Val 
    2030                 2035                 2040             


Lys Leu  Arg Ile Gly Arg Ser  Trp Gly Glu Phe Lys  Glu Val Ser 
    2045                 2050                 2055             


Val 
    


<210>  5
<211>  900
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Asn Tyr Glu Ala Leu Val Gly Phe Asp Leu Cys Asn Thr Pro 
1               5                   10                  15      


Leu Ser Ser Val Ala Gln Lys Ile Met Ser Ala Met His Ser Gly Asp 
            20                  25                  30          


Leu Val Asp Ser Lys Thr Trp Gly Lys Ser Thr Glu Thr Met Glu Val 
        35                  40                  45              


Ile Asn Lys Ser Ser Val Lys Tyr Ser Val Gln Leu Glu Asp Arg Lys 
    50                  55                  60                  


Thr Gln Ser Pro Glu Lys Lys Asp Leu Lys Ser Leu Arg Ser Gln Thr 
65                  70                  75                  80  


Ser Arg Gly Ser Ala Lys Leu Ser Pro Gln Ser Phe Ser Val Arg Leu 
                85                  90                  95      


Thr Asp Gln Leu Ser Ala Asp Gln Lys Gln Lys Ser Ile Ser Ser Leu 
            100                 105                 110         


Thr Leu Ser Ser Cys Leu Ile Pro Gln Tyr Asn Gln Glu Ala Ser Val 
        115                 120                 125             


Leu Gln Lys Lys Gly His Lys Arg Lys His Phe Leu Met Glu Asn Ile 
    130                 135                 140                 


Asn Asn Glu Asn Lys Gly Ser Ile Asn Leu Lys Arg Lys His Ile Thr 
145                 150                 155                 160 


Tyr Asn Asn Leu Ser Glu Lys Thr Ser Lys Gln Met Ala Leu Glu Glu 
                165                 170                 175     


Asp Thr Asp Asp Ala Glu Gly Tyr Leu Asn Ser Gly Asn Ser Gly Ala 
            180                 185                 190         


Leu Lys Lys His Phe Cys Asp Ile Arg His Leu Asp Asp Trp Ala Lys 
        195                 200                 205             


Ser Gln Leu Ile Glu Met Leu Lys Gln Ala Ala Ala Leu Val Ile Thr 
    210                 215                 220                 


Val Met Tyr Thr Asp Gly Ser Thr Gln Leu Gly Ala Asp Gln Thr Pro 
225                 230                 235                 240 


Val Ser Ser Val Arg Gly Ile Val Val Leu Val Lys Arg Gln Ala Glu 
                245                 250                 255     


Gly Gly His Gly Cys Pro Asp Ala Pro Ala Cys Gly Pro Val Leu Glu 
            260                 265                 270         


Gly Phe Val Ser Asp Asp Pro Cys Ile Tyr Ile Gln Ile Glu His Ser 
        275                 280                 285             


Ala Ile Trp Asp Gln Glu Gln Glu Ala His Gln Gln Phe Ala Arg Asn 
    290                 295                 300                 


Val Leu Phe Gln Thr Met Lys Cys Lys Cys Pro Val Ile Cys Phe Asn 
305                 310                 315                 320 


Ala Lys Asp Phe Val Arg Ile Val Leu Gln Phe Phe Gly Asn Asp Gly 
                325                 330                 335     


Ser Trp Lys His Val Ala Asp Phe Ile Gly Leu Asp Pro Arg Ile Ala 
            340                 345                 350         


Ala Trp Leu Ile Asp Pro Ser Asp Ala Thr Pro Ser Phe Glu Asp Leu 
        355                 360                 365             


Val Glu Lys Tyr Cys Glu Lys Ser Ile Thr Val Lys Val Asn Ser Thr 
    370                 375                 380                 


Tyr Gly Asn Ser Ser Arg Asn Ile Val Asn Gln Asn Val Arg Glu Asn 
385                 390                 395                 400 


Leu Lys Thr Leu Tyr Arg Leu Thr Met Asp Leu Cys Ser Lys Leu Lys 
                405                 410                 415     


Asp Tyr Gly Leu Trp Gln Leu Phe Arg Thr Leu Glu Leu Pro Leu Ile 
            420                 425                 430         


Pro Ile Leu Ala Val Met Glu Ser His Ala Ile Gln Val Asn Lys Glu 
        435                 440                 445             


Glu Met Glu Lys Thr Ser Ala Leu Leu Gly Ala Arg Leu Lys Glu Leu 
    450                 455                 460                 


Glu Gln Glu Ala His Phe Val Ala Gly Glu Arg Phe Leu Ile Thr Ser 
465                 470                 475                 480 


Asn Asn Gln Leu Arg Glu Ile Leu Phe Gly Lys Leu Lys Leu His Leu 
                485                 490                 495     


Leu Ser Gln Arg Asn Ser Leu Pro Arg Thr Gly Leu Gln Lys Tyr Pro 
            500                 505                 510         


Ser Thr Ser Glu Ala Val Leu Asn Ala Leu Arg Asp Leu His Pro Leu 
        515                 520                 525             


Pro Lys Ile Ile Leu Glu Tyr Arg Gln Val His Lys Ile Lys Ser Thr 
    530                 535                 540                 


Phe Val Asp Gly Leu Leu Ala Cys Met Lys Lys Gly Ser Ile Ser Ser 
545                 550                 555                 560 


Thr Trp Asn Gln Thr Gly Thr Val Thr Gly Arg Leu Ser Ala Lys His 
                565                 570                 575     


Pro Asn Ile Gln Gly Ile Ser Lys His Pro Ile Gln Ile Thr Thr Pro 
            580                 585                 590         


Lys Asn Phe Lys Gly Lys Glu Asp Lys Ile Leu Thr Ile Ser Pro Arg 
        595                 600                 605             


Ala Met Phe Val Ser Ser Lys Gly His Thr Phe Leu Ala Ala Asp Phe 
    610                 615                 620                 


Ser Gln Ile Glu Leu Arg Ile Leu Thr His Leu Ser Gly Asp Pro Glu 
625                 630                 635                 640 


Leu Leu Lys Leu Phe Gln Glu Ser Glu Arg Asp Asp Val Phe Ser Thr 
                645                 650                 655     


Leu Thr Ser Gln Trp Lys Asp Val Pro Val Glu Gln Val Thr His Ala 
            660                 665                 670         


Asp Arg Glu Gln Thr Lys Lys Val Val Tyr Ala Val Val Tyr Gly Ala 
        675                 680                 685             


Gly Lys Glu Arg Leu Ala Ala Cys Leu Gly Val Pro Ile Gln Glu Ala 
    690                 695                 700                 


Ala Gln Phe Leu Glu Ser Phe Leu Gln Lys Tyr Lys Lys Ile Lys Asp 
705                 710                 715                 720 


Phe Ala Arg Ala Ala Ile Ala Gln Cys His Gln Thr Gly Cys Val Val 
                725                 730                 735     


Ser Ile Met Gly Arg Arg Arg Pro Leu Pro Arg Ile His Ala His Asp 
            740                 745                 750         


Gln Gln Leu Arg Ala Gln Ala Glu Arg Gln Ala Val Asn Phe Val Val 
        755                 760                 765             


Gln Gly Ser Ala Ala Asp Leu Cys Lys Leu Ala Met Ile His Val Phe 
    770                 775                 780                 


Thr Ala Val Ala Ala Ser His Thr Leu Thr Ala Arg Leu Val Ala Gln 
785                 790                 795                 800 


Ile His Asp Glu Leu Leu Phe Glu Val Glu Asp Pro Gln Ile Pro Glu 
                805                 810                 815     


Cys Ala Ala Leu Val Arg Arg Thr Met Glu Ser Leu Glu Gln Val Gln 
            820                 825                 830         


Ala Leu Glu Leu Gln Leu Gln Val Pro Leu Lys Val Ser Leu Ser Ala 
        835                 840                 845             


Gly Arg Ser Trp Gly His Leu Val Pro Leu Gln Glu Ala Trp Gly Pro 
    850                 855                 860                 


Pro Pro Gly Pro Cys Arg Thr Glu Ser Pro Ser Asn Ser Leu Ala Ala 
865                 870                 875                 880 


Pro Gly Ser Pro Ala Ser Thr Gln Pro Pro Pro Leu His Phe Ser Pro 
                885                 890                 895     


Ser Phe Cys Leu 
            900 


<210>  6
<211>  864
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Asn Tyr Glu Ala Cys Val Gly Phe Asp Val Cys Glu Ile Pro 
1               5                   10                  15      


Leu Ser Ala Val Ala Gln Lys Ile Met Ser Ala Met Arg Ser Gly Asp 
            20                  25                  30          


Phe Met Asp Ser Arg Asn Glu Gly Glu Ser Thr Asn Thr Ser Lys Val 
        35                  40                  45              


Ala Lys Lys Ser Ser Val His Tyr Ser Val Leu Ala Glu His Glu Glu 
    50                  55                  60                  


Thr Gln Ser Leu Gly Thr Lys Asn Pro Glu Ser Leu Ile Thr Gln Thr 
65                  70                  75                  80  


Pro Arg Gly Ser Ile Glu Leu Cys Pro Gln Pro Ser Ile Thr Lys Leu 
                85                  90                  95      


Thr Cys Gln Leu Ser Ala Gly Gln Val Gln Asn Ser Ile Ser Ser Leu 
            100                 105                 110         


Gly Leu Ser Ser Tyr Leu Ile Pro Gln Cys Asp Gln Glu Ala Ser Val 
        115                 120                 125             


Leu Pro Asn Met Glu His Lys Arg Gln His Phe Leu Lys Glu Asn Ile 
    130                 135                 140                 


Gly Lys Glu Asp Lys Asp Asn Ser Ser Leu Lys Arg Lys Tyr Ile Thr 
145                 150                 155                 160 


Cys Ser Lys Ser Ser Glu Lys Ala Ser Lys His Thr Ala Leu Glu Lys 
                165                 170                 175     


Asp Thr Asp Gly Thr Glu Ser Trp Pro Asn Ser Arg Asp Thr Arg Ala 
            180                 185                 190         


Leu Gly Glu Arg Leu Cys Asp Val Arg Tyr Leu Gly Asp Leu Ala Lys 
        195                 200                 205             


Ala Gln Leu Met Asp Ala Leu Lys Gln Ala Ala Ala Leu Val Val Thr 
    210                 215                 220                 


Leu Met Tyr Lys Asp Gly Ser Thr Gln Leu Ser Ala Lys Glu Ala Leu 
225                 230                 235                 240 


Thr Cys Thr Val Lys Gly Ile Val Val Leu Leu Lys Ser His Val Gly 
                245                 250                 255     


Asn Ser Thr Leu Thr Leu Pro Ala His Gly Gly Ala Leu Glu Lys Asp 
            260                 265                 270         


Phe Ile Ser Glu Asp His Cys Val Tyr Ile His Thr Glu His Ser Pro 
        275                 280                 285             


Phe Trp Asp Pro Lys Gln Glu Ala His Ser Leu Phe Val Arg Asn Ile 
    290                 295                 300                 


Leu Phe Trp Thr Leu Arg Cys Lys Cys Pro Val Val Cys Phe Asn Ala 
305                 310                 315                 320 


Lys Asp Phe Val Arg Thr Val Leu Gln Leu Tyr Gly Glu Asp Gly Ser 
                325                 330                 335     


Trp Lys His Val Ala Asp Phe Val Gly Leu Asp Pro Arg Val Ala Ala 
            340                 345                 350         


Trp Leu Ile Asp Pro Ser Asp Thr Ala Pro Ser Phe Glu Asp Leu Val 
        355                 360                 365             


Ala Lys His Leu Glu Lys Ser Ile Thr Val Lys Pro Ser Ser Thr Phe 
    370                 375                 380                 


Arg Glu Ala Ser Arg Asn Thr Leu Ser Gln Asn Val Phe Met Asn Leu 
385                 390                 395                 400 


Lys Ile Leu Tyr Asp Leu Thr Met Asp Leu Cys Ser Lys Leu Lys Ala 
                405                 410                 415     


Tyr Gly Leu Trp Gln Leu Phe Cys Thr Leu Glu Leu Pro Leu Ile Pro 
            420                 425                 430         


Ile Leu Ala Val Met Glu Asn His Lys Ile Pro Val Asp Lys Glu Glu 
        435                 440                 445             


Met Glu Arg Thr Ser Ala Leu Leu Gly Ala Arg Leu Lys Glu Leu Glu 
    450                 455                 460                 


Gln Glu Ala His Phe Val Ala Gly Glu Gln Phe Leu Ile Met Ser Asn 
465                 470                 475                 480 


Asn Gln Leu Arg Glu Ile Leu Phe Gly Lys Leu Lys Leu His Leu Leu 
                485                 490                 495     


Ser Gln Arg Lys His Leu Pro Arg Thr Gly Leu Gln Asn Gln Leu Ser 
            500                 505                 510         


Thr Ser Glu Ala Met Leu Asn Ser Leu Gln Asp Leu His Pro Leu Pro 
        515                 520                 525             


Lys Leu Ile Leu Glu Tyr Arg Gln Val His Lys Ile Lys Ser Thr Phe 
    530                 535                 540                 


Ile Asp Gly Leu Leu Ala Tyr Met Lys Lys Gly Ser Ile Ser Ser Thr 
545                 550                 555                 560 


Trp Asn Gln Thr Gly Thr Val Thr Gly Arg Leu Ser Ala Lys His Pro 
                565                 570                 575     


Asn Ile Gln Gly Ile Ser Lys His Pro Ile Lys Ile Ser Lys Pro Trp 
            580                 585                 590         


Asn Phe Lys Gly Lys Glu Glu Glu Thr Val Thr Ile Ser Pro Arg Thr 
        595                 600                 605             


Leu Phe Val Ser Ser Glu Gly His Thr Phe Leu Ala Ala Asp Phe Ser 
    610                 615                 620                 


Gln Ile Glu Leu Arg Ile Leu Ala His Leu Ser Gly Asp Pro Glu Leu 
625                 630                 635                 640 


Leu Lys Leu Phe Gln Glu Ser Glu Arg Asp Asp Val Phe Ser Thr Leu 
                645                 650                 655     


Thr Ser Gln Trp Lys Asp Ile Pro Ile Glu Arg Val Thr His Met Asp 
            660                 665                 670         


Arg Glu Gln Thr Lys Lys Val Val Tyr Ser Val Val Tyr Gly Ala Gly 
        675                 680                 685             


Lys Glu Arg Leu Ala Ala Cys Leu Gly Val Thr Val Leu Glu Ala Thr 
    690                 695                 700                 


His Phe Leu Glu Arg Phe Leu Gln Lys Tyr Lys Lys Ile Lys Asp Phe 
705                 710                 715                 720 


Ala Gln Thr Val Ile Gly Gln Cys His Ser Ala Gly Tyr Val Thr Ser 
                725                 730                 735     


Ile Leu Gly Arg Arg Arg Pro Leu Pro Arg Ile Cys Ala Gln Asp Gln 
            740                 745                 750         


Gln Leu Arg Ala Gln Ala Glu Arg Gln Ala Val Asn Phe Val Val Gln 
        755                 760                 765             


Gly Ser Ala Ala Asp Leu Cys Lys Leu Ala Met Ile Arg Ile Ser Thr 
    770                 775                 780                 


Ala Val Ala Thr Ser Pro Thr Leu Thr Ala Arg Leu Val Ala Gln Ile 
785                 790                 795                 800 


His Asp Glu Leu Leu Phe Glu Val Glu Asp Thr Gln Val Pro Glu Phe 
                805                 810                 815     


Ala Ala Leu Val Arg Arg Ile Met Glu Ser Leu Gln Gln Val Gln Thr 
            820                 825                 830         


Leu Glu Leu Gln Leu Gln Val Pro Leu Lys Val Asn Leu Ser Val Gly 
        835                 840                 845             


Arg Ser Trp Gly His Leu Thr Pro Leu Gln Glu Ile Leu Gly Ser Ala 
    850                 855                 860                 


<210>  7
<211>  834
<212>  PRT
<213>  Thermus aquaticus

<400>  7

Met Glu Ala Met Leu Pro Leu Phe Glu Pro Lys Gly Arg Val Leu Leu 
1               5                   10                  15      


Val Asp Gly His His Leu Ala Tyr Arg Thr Phe Phe Ala Leu Lys Gly 
            20                  25                  30          


Leu Thr Thr Ser Arg Gly Glu Pro Val Gln Ala Val Tyr Gly Phe Ala 
        35                  40                  45              


Lys Ser Leu Leu Lys Ala Leu Lys Glu Asp Gly Tyr Lys Ala Val Phe 
    50                  55                  60                  


Val Val Phe Asp Ala Lys Ala Pro Ser Phe Arg His Glu Ala Tyr Glu 
65                  70                  75                  80  


Ala Tyr Lys Ala Gly Arg Ala Pro Thr Pro Glu Asp Phe Pro Arg Gln 
                85                  90                  95      


Leu Ala Leu Ile Lys Glu Leu Val Asp Leu Leu Gly Phe Thr Arg Leu 
            100                 105                 110         


Glu Val Pro Gly Tyr Glu Ala Asp Asp Val Leu Ala Thr Leu Ala Lys 
        115                 120                 125             


Lys Ala Glu Lys Glu Gly Tyr Glu Val Arg Ile Leu Thr Ala Asp Arg 
    130                 135                 140                 


Asp Leu Tyr Gln Leu Val Ser Asp Arg Val Ala Val Leu His Pro Glu 
145                 150                 155                 160 


Gly His Leu Ile Thr Pro Glu Trp Leu Trp Glu Lys Tyr Gly Leu Arg 
                165                 170                 175     


Pro Glu Gln Trp Val Asp Phe Arg Ala Leu Val Gly Asp Pro Ser Asp 
            180                 185                 190         


Asn Leu Pro Gly Val Lys Gly Ile Gly Glu Lys Thr Ala Leu Lys Leu 
        195                 200                 205             


Leu Lys Glu Trp Gly Ser Leu Glu Asn Leu Leu Lys Asn Leu Asp Arg 
    210                 215                 220                 


Val Lys Pro Glu Asn Val Arg Glu Lys Ile Lys Ala His Leu Glu Asp 
225                 230                 235                 240 


Leu Arg Leu Ser Leu Glu Leu Ser Arg Val Arg Thr Asp Leu Pro Leu 
                245                 250                 255     


Glu Val Asp Leu Ala Gln Gly Arg Glu Pro Asp Arg Glu Gly Leu Arg 
            260                 265                 270         


Ala Phe Leu Glu Arg Leu Glu Phe Gly Ser Leu Leu His Glu Phe Gly 
        275                 280                 285             


Leu Leu Glu Ala Pro Ala Pro Leu Glu Glu Ala Pro Trp Pro Pro Pro 
    290                 295                 300                 


Glu Gly Ala Phe Val Gly Phe Val Leu Ser Arg Pro Glu Pro Met Trp 
305                 310                 315                 320 


Ala Glu Leu Lys Ala Leu Ala Ala Cys Arg Asp Gly Arg Val His Arg 
                325                 330                 335     


Ala Ala Asp Pro Leu Ala Gly Leu Lys Asp Leu Lys Glu Val Arg Gly 
            340                 345                 350         


Leu Leu Ala Lys Asp Leu Ala Val Leu Ala Ser Arg Glu Gly Leu Asp 
        355                 360                 365             


Leu Val Pro Gly Asp Asp Pro Met Leu Leu Ala Tyr Leu Leu Asp Pro 
    370                 375                 380                 


Ser Asn Thr Thr Pro Glu Gly Val Ala Arg Arg Tyr Gly Gly Glu Trp 
385                 390                 395                 400 


Thr Glu Asp Ala Ala His Arg Ala Leu Leu Ser Glu Arg Leu His Arg 
                405                 410                 415     


Asn Leu Leu Lys Arg Leu Glu Gly Glu Glu Lys Leu Leu Trp Leu Tyr 
            420                 425                 430         


His Glu Val Glu Lys Pro Leu Ser Arg Val Leu Ala His Met Glu Ala 
        435                 440                 445             


Thr Gly Val Arg Arg Asp Val Ala Tyr Leu Gln Ala Leu Ser Leu Glu 
    450                 455                 460                 


Leu Ala Glu Glu Ile Arg Arg Leu Glu Glu Glu Val Phe Arg Leu Ala 
465                 470                 475                 480 


Gly His Pro Phe Asn Leu Asn Ser Arg Asp Gln Leu Glu Arg Val Leu 
                485                 490                 495     


Phe Asp Glu Leu Arg Leu Pro Ala Leu Gly Lys Thr Gln Lys Thr Gly 
            500                 505                 510         


Lys Arg Ser Thr Ser Ala Ala Val Leu Glu Ala Leu Arg Glu Ala His 
        515                 520                 525             


Pro Ile Val Glu Lys Ile Leu Gln His Arg Glu Leu Thr Lys Leu Lys 
    530                 535                 540                 


Asn Thr Tyr Val Asp Pro Leu Pro Ser Leu Val His Pro Arg Thr Gly 
545                 550                 555                 560 


Arg Leu His Thr Arg Phe Asn Gln Thr Ala Thr Ala Thr Gly Arg Leu 
                565                 570                 575     


Ser Ser Ser Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Thr Pro Leu 
            580                 585                 590         


Gly Gln Arg Ile Arg Arg Ala Phe Val Ala Glu Ala Gly Trp Ala Leu 
        595                 600                 605             


Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala His Leu 
    610                 615                 620                 


Ser Gly Asp Glu Asn Leu Ile Arg Val Phe Gln Glu Gly Lys Asp Ile 
625                 630                 635                 640 


His Thr Gln Thr Ala Ser Trp Met Phe Gly Val Pro Pro Glu Ala Val 
                645                 650                 655     


Asp Pro Leu Met Arg Arg Ala Ala Lys Thr Val Asn Phe Gly Val Leu 
            660                 665                 670         


Tyr Gly Met Ser Ala His Arg Leu Ser Gln Glu Leu Ala Ile Pro Tyr 
        675                 680                 685             


Glu Glu Ala Val Ala Phe Ile Glu Arg Tyr Phe Gln Ser Phe Pro Lys 
    690                 695                 700                 


Val Arg Ala Trp Ile Glu Lys Thr Leu Glu Glu Gly Arg Lys Arg Gly 
705                 710                 715                 720 


Tyr Val Glu Thr Leu Phe Gly Arg Arg Arg Tyr Val Pro Asp Leu Asn 
                725                 730                 735     


Ala Arg Val Lys Ser Val Arg Glu Ala Ala Glu Arg Met Ala Phe Asn 
            740                 745                 750         


Met Pro Val Gln Gly Thr Ala Ala Asp Leu Met Lys Leu Ala Met Val 
        755                 760                 765             


Lys Leu Phe Pro Arg Leu Arg Glu Met Gly Ala Arg Met Leu Leu Gln 
    770                 775                 780                 


Val His Asp Glu Leu Leu Leu Glu Ala Pro Gln Ala Arg Ala Glu Glu 
785                 790                 795                 800 


Val Ala Ala Leu Ala Lys Glu Ala Met Glu Lys Ala Tyr Pro Leu Ala 
                805                 810                 815     


Val Pro Leu Glu Val Glu Val Gly Met Gly Glu Asp Trp Leu Ser Ala 
            820                 825                 830         


Lys Gly 
        


<210>  8
<211>  876
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  8

Met Lys Asn Lys Leu Val Leu Ile Asp Gly Asn Ser Val Ala Tyr Arg 
1               5                   10                  15      


Ala Phe Phe Ala Leu Pro Leu Leu His Asn Asp Lys Gly Ile His Thr 
            20                  25                  30          


Asn Ala Val Tyr Gly Phe Thr Met Met Leu Asn Lys Ile Leu Ala Glu 
        35                  40                  45              


Glu Gln Pro Thr His Ile Leu Val Ala Phe Asp Ala Gly Lys Thr Thr 
    50                  55                  60                  


Phe Arg His Glu Thr Phe Gln Asp Tyr Lys Gly Gly Arg Gln Gln Thr 
65                  70                  75                  80  


Pro Pro Glu Leu Ser Glu Gln Phe Pro Leu Leu Arg Glu Leu Leu Lys 
                85                  90                  95      


Ala Tyr Arg Ile Pro Ala Tyr Glu Leu Asp His Tyr Glu Ala Asp Asp 
            100                 105                 110         


Ile Ile Gly Thr Met Ala Ala Arg Ala Glu Arg Glu Gly Phe Ala Val 
        115                 120                 125             


Lys Val Ile Ser Gly Asp Arg Asp Leu Thr Gln Leu Ala Ser Pro Gln 
    130                 135                 140                 


Val Thr Val Glu Ile Thr Lys Lys Gly Ile Thr Asp Ile Glu Ser Tyr 
145                 150                 155                 160 


Thr Pro Glu Thr Val Val Glu Lys Tyr Gly Leu Thr Pro Glu Gln Ile 
                165                 170                 175     


Val Asp Leu Lys Gly Leu Met Gly Asp Lys Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Ile Gly Glu Lys Thr Ala Val Lys Leu Leu Lys Gln Phe 
        195                 200                 205             


Gly Thr Val Glu Asn Val Leu Ala Ser Ile Asp Glu Ile Lys Gly Glu 
    210                 215                 220                 


Lys Leu Lys Glu Asn Leu Arg Gln Tyr Arg Asp Leu Ala Leu Leu Ser 
225                 230                 235                 240 


Lys Gln Leu Ala Ala Ile Cys Arg Asp Ala Pro Val Glu Leu Thr Leu 
                245                 250                 255     


Asp Asp Ile Val Tyr Lys Gly Glu Asp Arg Glu Lys Val Val Ala Leu 
            260                 265                 270         


Phe Gln Glu Leu Gly Phe Gln Ser Phe Leu Asp Lys Met Ala Val Gln 
        275                 280                 285             


Thr Asp Glu Gly Glu Lys Pro Leu Ala Gly Met Asp Phe Ala Ile Ala 
    290                 295                 300                 


Asp Ser Val Thr Asp Glu Met Leu Ala Asp Lys Ala Ala Leu Val Val 
305                 310                 315                 320 


Glu Val Val Gly Asp Asn Tyr His His Ala Pro Ile Val Gly Ile Ala 
                325                 330                 335     


Leu Ala Asn Glu Arg Gly Arg Phe Phe Leu Arg Pro Glu Thr Ala Leu 
            340                 345                 350         


Ala Asp Pro Lys Phe Leu Ala Trp Leu Gly Asp Glu Thr Lys Lys Lys 
        355                 360                 365             


Thr Met Phe Asp Ser Lys Arg Ala Ala Val Ala Leu Lys Trp Lys Gly 
    370                 375                 380                 


Ile Glu Leu Arg Gly Val Val Phe Asp Leu Leu Leu Ala Ala Tyr Leu 
385                 390                 395                 400 


Leu Asp Pro Ala Gln Ala Ala Gly Asp Val Ala Ala Val Ala Lys Met 
                405                 410                 415     


His Gln Tyr Glu Ala Val Arg Ser Asp Glu Ala Val Tyr Gly Lys Gly 
            420                 425                 430         


Ala Lys Arg Thr Val Pro Asp Glu Pro Thr Leu Ala Glu His Leu Ala 
        435                 440                 445             


Arg Lys Ala Ala Ala Ile Trp Ala Leu Glu Glu Pro Leu Met Asp Glu 
    450                 455                 460                 


Leu Arg Arg Asn Glu Gln Asp Arg Leu Leu Thr Glu Leu Glu Gln Pro 
465                 470                 475                 480 


Leu Ala Gly Ile Leu Ala Asn Met Glu Phe Thr Gly Val Lys Val Asp 
                485                 490                 495     


Thr Lys Arg Leu Glu Gln Met Gly Ala Glu Leu Thr Glu Gln Leu Gln 
            500                 505                 510         


Ala Val Glu Arg Arg Ile Tyr Glu Leu Ala Gly Gln Glu Phe Asn Ile 
        515                 520                 525             


Asn Ser Pro Lys Gln Leu Gly Thr Val Leu Phe Asp Lys Leu Gln Leu 
    530                 535                 540                 


Pro Val Leu Lys Lys Thr Lys Thr Gly Tyr Ser Thr Ser Ala Asp Val 
545                 550                 555                 560 


Leu Glu Lys Leu Ala Pro His His Glu Ile Val Glu His Ile Leu His 
                565                 570                 575     


Tyr Arg Gln Leu Gly Lys Leu Gln Ser Thr Tyr Ile Glu Gly Leu Leu 
            580                 585                 590         


Lys Val Val His Pro Val Thr Gly Lys Val His Thr Met Phe Asn Gln 
        595                 600                 605             


Ala Leu Thr Gln Thr Gly Arg Leu Ser Ser Val Glu Pro Asn Leu Gln 
    610                 615                 620                 


Asn Ile Pro Ile Arg Leu Glu Glu Gly Arg Lys Ile Arg Gln Ala Phe 
625                 630                 635                 640 


Val Pro Ser Glu Pro Asp Trp Leu Ile Phe Ala Ala Asp Tyr Ser Gln 
                645                 650                 655     


Ile Glu Leu Arg Val Leu Ala His Ile Ala Glu Asp Asp Asn Leu Ile 
            660                 665                 670         


Glu Ala Phe Arg Arg Gly Leu Asp Ile His Thr Lys Thr Ala Met Asp 
        675                 680                 685             


Ile Phe His Val Ser Glu Glu Asp Val Thr Ala Asn Met Arg Arg Gln 
    690                 695                 700                 


Ala Lys Ala Val Asn Phe Gly Ile Val Tyr Gly Ile Ser Asp Tyr Gly 
705                 710                 715                 720 


Leu Ala Gln Asn Leu Asn Ile Thr Arg Lys Glu Ala Ala Glu Phe Ile 
                725                 730                 735     


Glu Arg Tyr Phe Ala Ser Phe Pro Gly Val Lys Gln Tyr Met Asp Asn 
            740                 745                 750         


Ile Val Gln Glu Ala Lys Gln Lys Gly Tyr Val Thr Thr Leu Leu His 
        755                 760                 765             


Arg Arg Arg Tyr Leu Pro Asp Ile Thr Ser Arg Asn Phe Asn Val Arg 
    770                 775                 780                 


Ser Phe Ala Glu Arg Thr Ala Met Asn Thr Pro Ile Gln Gly Ser Ala 
785                 790                 795                 800 


Ala Asp Ile Ile Lys Lys Ala Met Ile Asp Leu Ser Val Arg Leu Arg 
                805                 810                 815     


Glu Glu Arg Leu Gln Ala Arg Leu Leu Leu Gln Val His Asp Glu Leu 
            820                 825                 830         


Ile Leu Glu Ala Pro Lys Glu Glu Ile Glu Arg Leu Cys Arg Leu Val 
        835                 840                 845             


Pro Glu Val Met Glu Gln Ala Val Ala Leu Arg Val Pro Leu Lys Val 
    850                 855                 860                 


Asp Tyr His Tyr Gly Pro Thr Trp Tyr Asp Ala Lys 
865                 870                 875     


<210>  9
<211>  605
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu Glu Thr Leu 
1               5                   10                  15      


Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe Ala Phe Ala 
            20                  25                  30          


Thr Ala Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu Val Gly Leu 
        35                  40                  45              


Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro Val Ala His 
    50                  55                  60                  


Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg Ala Leu Glu 
65                  70                  75                  80  


Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys Val Gly Gln 
                85                  90                  95      


Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly Ile Glu Leu 
            100                 105                 110         


Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile Leu Asn Ser 
        115                 120                 125             


Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg Trp Leu Lys 
    130                 135                 140                 


His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly Lys Asn Gln 
145                 150                 155                 160 


Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg Tyr Ala Ala 
                165                 170                 175     


Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met Trp Pro Asp 
            180                 185                 190         


Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn Ile Glu Met 
        195                 200                 205             


Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly Val Lys Ile 
    210                 215                 220                 


Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr Leu Arg Leu 
225                 230                 235                 240 


Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu Glu Phe Asn 
                245                 250                 255     


Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu Lys Gln Gly 
            260                 265                 270         


Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser Thr Ser Glu 
        275                 280                 285             


Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro Lys Val Ile 
    290                 295                 300                 


Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr Thr Asp Lys 
305                 310                 315                 320 


Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His Thr Ser Tyr 
                325                 330                 335     


His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr Asp Pro Asn 
            340                 345                 350         


Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg Ile Arg Gln 
        355                 360                 365             


Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala Asp Tyr Ser 
    370                 375                 380                 


Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp Lys Gly Leu 
385                 390                 395                 400 


Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala Thr Ala Ala 
                405                 410                 415     


Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu Gln Arg Arg 
            420                 425                 430         


Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met Ser Ala Phe 
        435                 440                 445             


Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala Gln Lys Tyr 
    450                 455                 460                 


Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Glu Tyr Met Glu 
465                 470                 475                 480 


Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu Thr Leu Asp 
                485                 490                 495     


Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn Gly Ala Arg 
            500                 505                 510         


Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met Gln Gly Thr 
        515                 520                 525             


Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp Ala Trp Leu 
    530                 535                 540                 


Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val His Asp Glu 
545                 550                 555                 560 


Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val Ala Lys Gln 
                565                 570                 575     


Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val Pro Leu Leu 
            580                 585                 590         


Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        595                 600                 605 


<210>  10
<211>  928
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Val Gln Ile Pro Gln Asn Pro Leu Ile Leu Val Asp Gly Ser Ser 
1               5                   10                  15      


Tyr Leu Tyr Arg Ala Tyr His Ala Phe Pro Pro Leu Thr Asn Ser Ala 
            20                  25                  30          


Gly Glu Pro Thr Gly Ala Met Tyr Gly Val Leu Asn Met Leu Arg Ser 
        35                  40                  45              


Leu Ile Met Gln Tyr Lys Pro Thr His Ala Ala Val Val Phe Asp Ala 
    50                  55                  60                  


Lys Gly Lys Thr Phe Arg Asp Glu Leu Phe Glu His Tyr Lys Ser His 
65                  70                  75                  80  


Arg Pro Pro Met Pro Asp Asp Leu Arg Ala Gln Ile Glu Pro Leu His 
                85                  90                  95      


Ala Met Val Lys Ala Met Gly Leu Pro Leu Leu Ala Val Ser Gly Val 
            100                 105                 110         


Glu Ala Asp Asp Val Ile Gly Thr Leu Ala Arg Glu Ala Glu Lys Ala 
        115                 120                 125             


Gly Arg Pro Val Leu Ile Ser Thr Gly Asp Lys Asp Met Ala Gln Leu 
    130                 135                 140                 


Val Thr Pro Asn Ile Thr Leu Ile Asn Thr Met Thr Asn Thr Ile Leu 
145                 150                 155                 160 


Gly Pro Glu Glu Val Val Asn Lys Tyr Gly Val Pro Pro Glu Leu Ile 
                165                 170                 175     


Ile Asp Phe Leu Ala Leu Met Gly Asp Ser Ser Asp Asn Ile Pro Gly 
            180                 185                 190         


Val Pro Gly Val Gly Glu Lys Thr Ala Gln Ala Leu Leu Gln Gly Leu 
        195                 200                 205             


Gly Gly Leu Asp Thr Leu Tyr Ala Glu Pro Glu Lys Ile Ala Gly Leu 
    210                 215                 220                 


Ser Phe Arg Gly Ala Lys Thr Met Ala Ala Lys Leu Glu Gln Asn Lys 
225                 230                 235                 240 


Glu Val Ala Tyr Leu Ser Tyr Gln Leu Ala Thr Ile Lys Thr Asp Val 
                245                 250                 255     


Glu Leu Glu Leu Thr Cys Glu Gln Leu Glu Val Gln Gln Pro Ala Ala 
            260                 265                 270         


Glu Glu Leu Leu Gly Leu Phe Lys Lys Tyr Glu Phe Lys Arg Trp Thr 
        275                 280                 285             


Ala Asp Val Glu Ala Gly Lys Trp Leu Gln Ala Lys Gly Ala Lys Pro 
    290                 295                 300                 


Ala Ala Lys Pro Gln Glu Thr Ser Val Ala Asp Glu Ala Pro Glu Val 
305                 310                 315                 320 


Thr Ala Thr Val Ile Ser Tyr Asp Asn Tyr Val Thr Ile Leu Asp Glu 
                325                 330                 335     


Glu Thr Leu Lys Ala Trp Ile Ala Lys Leu Glu Lys Ala Pro Val Phe 
            340                 345                 350         


Ala Phe Asp Thr Glu Thr Asp Ser Leu Asp Asn Ile Ser Ala Asn Leu 
        355                 360                 365             


Val Gly Leu Ser Phe Ala Ile Glu Pro Gly Val Ala Ala Tyr Ile Pro 
    370                 375                 380                 


Val Ala His Asp Tyr Leu Asp Ala Pro Asp Gln Ile Ser Arg Glu Arg 
385                 390                 395                 400 


Ala Leu Glu Leu Leu Lys Pro Leu Leu Glu Asp Glu Lys Ala Leu Lys 
                405                 410                 415     


Val Gly Gln Asn Leu Lys Tyr Asp Arg Gly Ile Leu Ala Asn Tyr Gly 
            420                 425                 430         


Ile Glu Leu Arg Gly Ile Ala Phe Asp Thr Met Leu Glu Ser Tyr Ile 
        435                 440                 445             


Leu Asn Ser Val Ala Gly Arg His Asp Met Asp Ser Leu Ala Glu Arg 
    450                 455                 460                 


Trp Leu Lys His Lys Thr Ile Thr Phe Glu Glu Ile Ala Gly Lys Gly 
465                 470                 475                 480 


Lys Asn Gln Leu Thr Phe Asn Gln Ile Ala Leu Glu Glu Ala Gly Arg 
                485                 490                 495     


Tyr Ala Ala Glu Asp Ala Asp Val Thr Leu Gln Leu His Leu Lys Met 
            500                 505                 510         


Trp Pro Asp Leu Gln Lys His Lys Gly Pro Leu Asn Val Phe Glu Asn 
        515                 520                 525             


Ile Glu Met Pro Leu Val Pro Val Leu Ser Arg Ile Glu Arg Asn Gly 
    530                 535                 540                 


Val Lys Ile Asp Pro Lys Val Leu His Asn His Ser Glu Glu Leu Thr 
545                 550                 555                 560 


Leu Arg Leu Ala Glu Leu Glu Lys Lys Ala His Glu Ile Ala Gly Glu 
                565                 570                 575     


Glu Phe Asn Leu Ser Ser Thr Lys Gln Leu Gln Thr Ile Leu Phe Glu 
            580                 585                 590         


Lys Gln Gly Ile Lys Pro Leu Lys Lys Thr Pro Gly Gly Ala Pro Ser 
        595                 600                 605             


Thr Ser Glu Glu Val Leu Glu Glu Leu Ala Leu Asp Tyr Pro Leu Pro 
    610                 615                 620                 


Lys Val Ile Leu Glu Tyr Arg Gly Leu Ala Lys Leu Lys Ser Thr Tyr 
625                 630                 635                 640 


Thr Asp Lys Leu Pro Leu Met Ile Asn Pro Lys Thr Gly Arg Val His 
                645                 650                 655     


Thr Ser Tyr His Gln Ala Val Thr Ala Thr Gly Arg Leu Ser Ser Thr 
            660                 665                 670         


Asp Pro Asn Leu Gln Asn Ile Pro Val Arg Asn Glu Glu Gly Arg Arg 
        675                 680                 685             


Ile Arg Gln Ala Phe Ile Ala Pro Glu Asp Tyr Val Ile Val Ser Ala 
    690                 695                 700                 


Asp Tyr Ser Gln Ile Glu Leu Arg Ile Met Ala His Leu Ser Arg Asp 
705                 710                 715                 720 


Lys Gly Leu Leu Thr Ala Phe Ala Glu Gly Lys Asp Ile His Arg Ala 
                725                 730                 735     


Thr Ala Ala Glu Val Phe Gly Leu Pro Leu Glu Thr Val Thr Ser Glu 
            740                 745                 750         


Gln Arg Arg Ser Ala Lys Ala Ile Asn Phe Gly Leu Ile Tyr Gly Met 
        755                 760                 765             


Ser Ala Phe Gly Leu Ala Arg Gln Leu Asn Ile Pro Arg Lys Glu Ala 
    770                 775                 780                 


Gln Lys Tyr Met Asp Leu Tyr Phe Glu Arg Tyr Pro Gly Val Leu Glu 
785                 790                 795                 800 


Tyr Met Glu Arg Thr Arg Ala Gln Ala Lys Glu Gln Gly Tyr Val Glu 
                805                 810                 815     


Thr Leu Asp Gly Arg Arg Leu Tyr Leu Pro Asp Ile Lys Ser Ser Asn 
            820                 825                 830         


Gly Ala Arg Arg Ala Ala Ala Glu Arg Ala Ala Ile Asn Ala Pro Met 
        835                 840                 845             


Gln Gly Thr Ala Ala Asp Ile Ile Lys Arg Ala Met Ile Ala Val Asp 
    850                 855                 860                 


Ala Trp Leu Gln Ala Glu Gln Pro Arg Val Arg Met Ile Met Gln Val 
865                 870                 875                 880 


His Asp Glu Leu Val Phe Glu Val His Lys Asp Asp Val Asp Ala Val 
                885                 890                 895     


Ala Lys Gln Ile His Gln Leu Met Glu Asn Cys Thr Arg Leu Asp Val 
            900                 905                 910         


Pro Leu Leu Val Glu Val Gly Ser Gly Glu Asn Trp Asp Gln Ala His 
        915                 920                 925             


<210>  11
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  11

Leu Leu Val Ala Leu Asp Tyr Ser Gln Ile Glu Leu Arg Val Leu Ala 
1               5                   10                  15      


His 
    


<210>  12
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  12

Ser Ile Leu Ala Ala Asp Tyr Ser Gln Leu Glu Leu Arg Ile Leu Ala 
1               5                   10                  15      


His 
    


<210>  13
<211>  14
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic desoxynucleotide

<400>  13
tacgcattag cata                                                         14


<210>  14
<211>  15
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligoribonucleotide

<400>  14
uacgcauuag caaug                                                        15


<210>  15
<211>  15
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligoribonucleotide

<400>  15
uuaugcuaau guccc                                                        15


<210>  16
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  16
tgactactct cagcttggac tgaggatctt ggctc                                  35


<210>  17
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  17
gagccaagat cctcagtcca agctgagagt agtca                                  35


<210>  18
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  18
catgcctttg tgcctttcgt aggtggttca atactggc                               38


<210>  19
<211>  38
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  19
gccagtattg aaccacctac gaaaggcaca aaggcatg                               38


<210>  20
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  20
gcagcaggca aaacagattt gctttgggat catttatgg                              39


<210>  21
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  21
ccataaatga tcccaaagca aatctgtttt gcctgctgc                              39


<210>  22
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligoonucleotide

<400>  22
ggctgctgac tactctcaga tgggactgag gatcttggct cat                         43


<210>  23
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  23
atgagccaag atcctcagtc ccatctgaga gtagtcagca gcc                         43


<210>  24
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  24
aggtggttca atactggttg ctgactactc tcacg                                  35


<210>  25
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  25
gctgagagta gtcagcaacc agtattgaac cacct                                  35


<210>  26
<211>  15
<212>  RNA
<213>  artificial sequence

<220>
<223>  synthetic oligonucleotide

<400>  26
gggacauuag cauaa                                                        15


