                         SEQUENCE LISTING

<110>  Universitt Heidelberg
       Deutsches Krebsforschungszentrum
 
<120>  Norovirus antibodies

<130>  UH14750PC

<150>  EP17192166.1
<151>  2017-09-20

<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  548
<212>  PRT
<213>  norovirus genotype II.10

<400>  1

Met Lys Met Ala Ser Asn Asp Ala Ala Pro Ser Asn Asp Gly Ala Ala 
1               5                   10                  15      


Gly Leu Val Pro Glu Ser Asn Asn Glu Val Met Ala Leu Glu Pro Val 
            20                  25                  30          


Ala Gly Ala Ser Leu Ala Ala Pro Val Thr Gly Gln Thr Asn Ile Ile 
        35                  40                  45              


Asp Pro Trp Ile Arg Met Asn Phe Val Gln Ala Pro Asn Gly Glu Phe 
    50                  55                  60                  


Thr Val Ser Pro Arg Asn Ser Pro Gly Glu Val Leu Leu Asn Leu Glu 
65                  70                  75                  80  


Leu Gly Pro Glu Leu Asn Pro Tyr Leu Ala His Leu Ser Arg Met Tyr 
                85                  90                  95      


Asn Gly Tyr Ala Gly Gly Met Glu Val Gln Ile Met Leu Ala Gly Asn 
            100                 105                 110         


Ala Phe Thr Ala Gly Lys Leu Ile Phe Ala Ala Val Pro Pro His Phe 
        115                 120                 125             


Pro Ile Glu Asn Leu Ser Pro Pro Gln Ile Thr Met Phe Pro His Val 
    130                 135                 140                 


Ile Ile Asp Val Arg Thr Leu Glu Pro Val Leu Leu Pro Met Pro Asp 
145                 150                 155                 160 


Ile Arg Asn Ser Phe Phe His Phe Ile Gln Arg Asp Glu Pro Lys Met 
                165                 170                 175     


Arg Leu Val Ala Met Leu Tyr Thr Pro Leu Arg Ser Asn Gly Ser Gly 
            180                 185                 190         


Asp Asp Val Phe Thr Val Ser Cys Arg Val Leu Thr Arg Pro Thr Pro 
        195                 200                 205             


Asp Phe Asp Phe Thr Tyr Leu Val Pro Pro Thr Val Glu Ser Lys Ser 
    210                 215                 220                 


Lys Pro Phe Thr Leu Pro Ile Leu Thr Leu Gly Glu Leu Thr Asn Ser 
225                 230                 235                 240 


Arg Phe Pro Leu Pro Ile Asp Val Leu Tyr Thr Asn Pro Asn Glu Ser 
                245                 250                 255     


Ala Ile Val Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu 
            260                 265                 270         


Gln Gly Thr Thr Gln Leu Leu Pro Thr Gly Ile Cys Ala Phe Arg Gly 
        275                 280                 285             


Lys Val Thr Gln Gln Val Gln Asp Glu His Arg Gly Thr His Trp Asn 
    290                 295                 300                 


Met Thr Val Thr Asn Leu Asn Gly Thr Pro Phe Asp Pro Thr Glu Asp 
305                 310                 315                 320 


Val Pro Ala Pro Leu Gly Thr Pro Asp Phe Ser Gly Gln Ile Tyr Gly 
                325                 330                 335     


Val Ile Ser Gln Arg Asn Thr Asn Thr Val Pro Gly Glu Gly Asn Leu 
            340                 345                 350         


Pro Ala Asn Arg Ala His Glu Ala Val Ile Ala Thr Tyr Ser Pro Lys 
        355                 360                 365             


Phe Thr Pro Lys Leu Gly Asn Ile Gln Phe Ser Thr Trp Glu Thr Gln 
    370                 375                 380                 


Asp Val Ser Ser Gly Gln Pro Thr Lys Phe Thr Pro Val Gly Leu Ala 
385                 390                 395                 400 


Ser Val Asp Ala Asn Ser His Phe Asp Gln Trp Thr Leu Pro Ser Tyr 
                405                 410                 415     


Ser Gly Ala Leu Thr Leu Asn Met Asn Leu Ala Pro Ser Val Ala Pro 
            420                 425                 430         


Val Phe Pro Gly Glu Cys Leu Leu Phe Phe Arg Ser Phe Ile Pro Leu 
        435                 440                 445             


Lys Gly Gly Tyr Gly Asn Pro Ala Ile Asp Cys Leu Met Pro Gln Glu 
    450                 455                 460                 


Trp Val Gln His Leu Tyr Gln Glu Ser Ala Pro Ser Leu Ser Asp Val 
465                 470                 475                 480 


Ala Leu Val Arg Tyr Val Asn Pro Glu Thr Gly Arg Thr Leu Phe Glu 
                485                 490                 495     


Ala Lys Leu His Arg Asn Gly Phe Leu Thr Val Ala Arg Asn Ser Ala 
            500                 505                 510         


Gly Pro Val Val Ala Pro Thr Asn Gly Tyr Phe Arg Phe Asp Ser Trp 
        515                 520                 525             


Val Asn Gln Phe Tyr Thr Leu Ala Pro Met Gly Asn Gly Ser Gly Arg 
    530                 535                 540                 


Arg Arg Met Gln 
545             


<210>  2
<211>  51
<212>  PRT
<213>  norovirus genotype II.10

<400>  2

Tyr Thr Asn Pro Asn Glu Ser Ala Ile Val Gln Cys Gln Asn Gly Arg 
1               5                   10                  15      


Cys Thr Leu Asp Gly Glu Leu Gln Gly Thr Thr Gln Leu Leu Pro Thr 
            20                  25                  30          


Gly Ile Cys Ala Phe Arg Gly Lys Val Thr Gln Gln Val Gln Asp Glu 
        35                  40                  45              


His Arg Gly 
    50      


<210>  3
<211>  21
<212>  PRT
<213>  norovirus genotype II.10

<400>  3

Gln Cys Gln Asn Gly Arg Cys Thr Leu Asp Gly Glu Leu Gln Gly Thr 
1               5                   10                  15      


Thr Gln Leu Leu Pro 
            20      


<210>  4
<211>  8
<212>  PRT
<213>  norovirus genotype II.10

<400>  4

Asp Gly Glu Leu Gln Gly Thr Thr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  epitope consensus 1


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  acidic amino acid, E or D

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  acidic amino acid, E or D

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  hydrophobic amino acid, G, A, V, or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  hydrophobic amino acid, G, A, V, or I

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  S or T

<400>  5

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  epitope 1, consensus 2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  any amino acid

<400>  6

Asp Xaa Glu Leu Xaa Gly Xaa Thr 
1               5               


<210>  7
<211>  41
<212>  PRT
<213>  norovirus genotype II.10

<400>  7

Gly Gly Tyr Gly Asn Pro Ala Ile Asp Cys Leu Met Pro Gln Glu Trp 
1               5                   10                  15      


Val Gln His Leu Tyr Gln Glu Ser Ala Pro Ser Leu Ser Asp Val Ala 
            20                  25                  30          


Leu Val Arg Tyr Val Asn Pro Glu Thr 
        35                  40      


<210>  8
<211>  19
<212>  PRT
<213>  norovirus genotype II.10

<400>  8

Tyr Gln Glu Ser Ala Pro Ser Leu Ser Asp Val Ala Leu Val Arg Tyr 
1               5                   10                  15      


Val Asn Pro 
            


<210>  9
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  epitope 2 consensus 1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N or Q

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  D or E

<220>
<221>  misc_feature
<222>  (3)..(17)
<223>  x = any amino acid

<400>  9

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Pro 
        


<210>  10
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  epitope 2 consensus 2


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  x = any amino acid

<220>
<221>  misc_feature
<222>  (7)..(18)
<223>  x = any amino acid

<400>  10

Tyr Gln Glu Ser Xaa Pro Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Pro 
            


<210>  11
<211>  115
<212>  PRT
<213>  Vicugna pacos

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Pro Arg Ile Ile Phe Phe Met Tyr 
            20                  25                  30          


Asp Val Gly Trp Tyr Arg Gln Ala Pro Glu Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Gln Ile Asn Ser Asp Val Ser Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asp Leu Lys Pro Glu Asp Ala Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Arg Arg Ala Ser Ala Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  12
<211>  345
<212>  DNA
<213>  Vicugna pacos

<400>  12
caggtgcagc tgcaggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc     60

tcctgtacag ctcctcgaat tattttcttt atgtatgacg tgggctggta tcgccaggct    120

ccagagaagc agcgcgaatt ggtcgcacag attaacagtg atgttagcac gaagtatgca    180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaggac ggtgtatcta    240

caaatgaacg acctgaaacc tgaggacgcg gccgtgtatt actgtaatgt acggcgagcc    300

tcagccgact attggggcca ggggacccag gtcaccgtct cctca                    345


<210>  13
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  13

Arg Ile Ile Phe Phe Met Tyr Asp 
1               5               


<210>  14
<211>  24
<212>  DNA
<213>  Vicugna pacos

<400>  14
cgaattattt tctttatgta tgac                                            24


<210>  15
<211>  8
<212>  PRT
<213>  Vicugna pacos

<400>  15

Gln Ile Asn Ser Asp Val Ser Thr 
1               5               


<210>  16
<211>  24
<212>  DNA
<213>  Vicugna pacos

<400>  16
cagattaaca gtgatgttag cacg                                            24


<210>  17
<211>  9
<212>  PRT
<213>  Vicugna pacos

<400>  17

Tyr Cys Asn Val Arg Arg Ala Ser Ala 
1               5                   


<210>  18
<211>  27
<212>  DNA
<213>  Vicugna pacos

<400>  18
tactgtaatg tacggcgagc ctcagcc                                         27


<210>  19
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  epitope of second binding polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  x = any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  x = any amino acid

<400>  19

Trp Val Asn Xaa Phe Tyr Xaa 
1               5           


<210>  20
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  y is t or c

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  r is g or a

<400>  20
atgttyagrt ggatgagatt ctc                                             23


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  21
tcgacgccat cttcattcac                                                 20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR probe

<400>  22
tgggagggcg atcgcaatct                                                 20


